TAGUCHI Hiroyasu 田口弘康

… Alternative Names

田口弘康タグチヒロヤス

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Researcher Number	90102912
Other IDs
Affiliation (based on the past Project Information) *help	2016 – 2021: 滋賀医科大学, 神経難病研究センター, 特任教授 2009 – 2015: 滋賀医科大学, 分子神経科学研究センター, 特任教授 2013: 滋賀医科大学, 分子神経科学研究センター, 特任教授 2007: 滋賀医科大学, 分子神経科学研究センター, 客員教授
Review Section/Research Field	Principal Investigator Basic Section 90110:Biomedical engineering-related / Biomedical engineering/Biomaterial science and engineering Except Principal Investigator Biomedical engineering/Biological material science / Basic Section 28030:Nanomaterials-related / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 核磁気共鳴画像 / 認知用 / 有機合成成 / Aβオリゴマー / 画像診断法 / アルツハイマー病 / 治療薬 / フッ素MRI / アミロイドβオリゴマー / 有機合成 … More / 画像診断 / MRI / 認知症 / 診断薬 / 神経科学 / 脳神経疾患 / 有機化学 … More Except Principal Investigator アルツハイマー病 / 核磁気共鳴画像 / オリゴマー / 診断 / 神経科学 / 診断薬 / ナノバイオ材料 / アミロイドイメージング / 走査型プローブ顕微鏡 / 電気泳動法 / 走査トンネル顕微鏡 / ヒストグラム / 電気泳動 / エタノール / 原子間力顕微鏡 / クルクミン誘導体 / クルクミン / 統計解析 / 走査プローブ顕微鏡 / アミロイドβ / 老化 / 神経化学 / 認知症 / タウタンパク / ベータアミロイド / アミロイドオリゴマー / 治療 / 脳神経疾患 / フッ素 / MR画像 / 神経変性疾患 / 核磁気共鳴医学 / 画像診断 / 分子イメージング / 超常磁性酸化鉄 / フッ素MR画像法 / 核磁気共鳴 / パーキンソン病 Less

Microscopic analysis of amyloid beta oligomers to elucidate the function of candidate medicinal agents for Alzheimer's disease
- Principal Investigator
  
  Naruse Nobuyasu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 28030:Nanomaterials-related
- Research Institution
  Shiga University of Medical Science
Development of novel ligands for in vivo imaging of amyloid oligomers in the brain of Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Taguchi Hiroyasu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Shiga University of Medical Science
Development novel probes for fluorine MRI to detect neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  Taguchi Hiroyasu
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Shiga University of Medical Science
Development of novel diagnostic and therapeutic methods on Alzheimer's disease by targeting amyloid oligomers
- Principal Investigator
  
  Tooyama Ikuo
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Shiga University of Medical Science
Development of amyloid imaging using fluorine-MRI
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Shiga University of Medical Science
Development of diagnostic methods for Parkinson disease using high fieled magnetic resonance imaging
- Principal Investigator
  
  TOOYAMA Ikuo
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Shiga University of Medical Science

[Book] FRUITS, VEGETABLES AND HERBS: Bioactive Foods in Health Promotion2017
- Author(s)
  Ikuo Tooyama, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Mohd Hanafi Ahmad Damanhuri, Wan Zurinah Wan Ngah, Hiroyasu Taguchi and Daijiro Yanagisawa
- Total Pages
  593
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-15K01282
[Book] FRUITS, VEGETABLES AND HERBS: Bioactive Foods in Health Promotion2016
- Author(s)
  Tooyama I, Ibrahim NF, Durani LW, Haemzah HS, Damanhuri MHA, Wan Ngah WZ, Taguchi H, Yanagisawa D
- Total Pages
  593
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26290022
[Journal Article] The Effect of Ethanol on Disassembly of Amyloid-β1-42 Pentamer Revealed by Atomic Force Microscopy and Gel Electrophoresis2022
- Author(s)
  Matsui Atsuya、Bellier Jean-Pierre、Kanai Takeshi、Satooka Hiroki、Nakanishi Akio、Terada Tsukasa、Ishibe Takafumi、Nakamura Yoshiaki、Taguchi Hiroyasu、Naruse Nobuyasu、Mera Yutaka
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 2 Pages: 889-889
- DOI
  10.3390/ijms23020889
- NAID
  120007186917
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08853, KAKENHI-PROJECT-19K05207, KAKENHI-PROJECT-19K12780
[Journal Article] Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibrils2021
- Author(s)
  Yanagisawa D, Kato T, Taguchi H, Shirai N, Hirao K, Sogabe T, Tomiyama T, Gamo K, Hirahara Y, Kitada M, Tooyama I
- Journal Title
  
  Biomaterials
  
  Volume: 270 Pages: 120686-120686
- DOI
  10.1016/j.biomaterials.2021.120686
- NAID
  120006959909
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06814, KAKENHI-PROJECT-19K12780, KAKENHI-PROJECT-19K20670, KAKENHI-PROJECT-17H03560
[Journal Article] A Fluorine-19 Magnetic Resonance Probe, Shiga-Y5, Downregulates Thioredoxin-Interacting Protein Expression in the Brain of a Mouse Model of Alzheimer’s Disease2021
- Author(s)
  Pahrudin Arrozi Aslina、Abu Bakar Zulzikry Hafiz、Taguchi Hiroyasu、Yanagisawa Daijiro、Tooyama Ikuo
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 17 Pages: 5342-5342
- DOI
  10.3390/molecules26175342
- NAID
  120007147812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12780
[Journal Article] Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer’s Disease2021
- Author(s)
  Yanagisawa Daijiro、Ibrahim Nor Faeizah、Taguchi Hiroyasu、Morikawa Shigehiro、Tomiyama Takami、Tooyama Ikuo
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 5 Pages: 1362-1362
- DOI
  10.3390/molecules26051362
- NAID
  120007028249
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12780, KAKENHI-PROJECT-17H03560
[Journal Article] Novel fluorinated derivative of curcumin negatively regulates thioredoxin-interacting protein expression in retinal pigment epithelial and macrophage cells2020
- Author(s)
  Buyandelger Undral、Walker Douglas Gordon、Taguchi Hiroyasu、Yanagisawa Daijiro、Tooyama Ikuo
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 532 Issue: 4 Pages: 668-674
- DOI
  10.1016/j.bbrc.2020.08.114
- NAID
  120006887065
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12780, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-19K07843
[Journal Article] Oligomers imaging of amyloid-β 1-42 by scanning tunneling microscopy2019
- Author(s)
  Naruse Nobuyasu、Satooka Hiroki、Todo Kagefumi、Nakanishi Akio、Taguchi Hiroyasu、Mera Yutaka
- Journal Title
  
  Japanese Journal of Applied Physics
  
  Volume: 58 Issue: SI Pages: SIIB30-SIIB30
- DOI
  10.7567/1347-4065/ab203b
- NAID
  210000156784
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05207
[Journal Article] Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y52018
- Author(s)
  Yanagisawa Daijiro、Hamezah Hamizah Shahirah、Durani Lina Wati、Taguchi Hiroyasu、Tooyama Ikuo
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 12 Pages: e0208440-e0208440
- DOI
  10.1371/journal.pone.0208440
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17H03560, KAKENHI-PROJECT-15K01282
[Journal Article] Fluorine-19 magnetic resonance imaging probe for the detection of tau pathology in female rTg4510 mice2017
- Author(s)
  Yanagisawa Daijiro、Ibrahim Nor Faeizah、Taguchi Hiroyasu、Morikawa Shigehiro、Kato Tomoko、Hirao Koichi、Shirai Nobuaki、Sogabe Takayuki、Tooyama Ikuo
- Journal Title
  
  Journal of Neuroscience Research
  
  Volume: 96 Issue: 5 Pages: 841-851
- DOI
  10.1002/jnr.24188
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282, KAKENHI-PROJECT-17K01355, KAKENHI-PROJECT-17K01563, KAKENHI-PROJECT-26282145, KAKENHI-PROJECT-17H03560
[Journal Article] Amyloid imaging using fluorine-19 magnetic resonance imaging (19F-MRI).2016
- Author(s)
  Tooyama I, Yanagisawa D, Taguchi H, Kato T, Hirao K, Shirai N, Sogabe T, Ibrahim NF, Inubushi T, Morikawa S
- Journal Title
  
  Ageing Research Reviews
  
  Volume: 15 Pages: 1568-1637
- DOI
  10.1016/j.arr.2015.12.008
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K01282, KAKENHI-PROJECT-15K16321, KAKENHI-PUBLICLY-26111709, KAKENHI-PROJECT-24240071, KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26282145
[Journal Article] Novel curcumin derivatives as potent inhibitors of amyloid β aggregation.2015
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Biochem Biophys Report
  
  Volume: 4 Pages: 357-368
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290022
[Journal Article] Synthesis and Tautomerism of Curcumin Derivatives and Related Compounds.2015
- Author(s)
  Taguchi H, Yanagisawa D, Morikawa S, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Australian Journal of Chemistry
  
  Volume: 68 Pages: 224-229
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290022
[Journal Article] Novel curcumin derivatives as potent inhibitors of amyloid ß aggregation.2015
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Tooyama I
- Journal Title
  
  Biochem Biophys Report
  
  Volume: 4 Pages: 357-368
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K01282
[Journal Article] Curcumin derivative with substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PSI mice2014
- Author(s)
  Yanagisawa D, Ibraham NF, Taguchi H, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I
- Journal Title
  
  Neurobiol Aging
  
  Volume: 36 Issue: 1 Pages: 210-210
- DOI
  10.1016/j.neurobiolaging.2014.07.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24240020, KAKENHI-PROJECT-25750159, KAKENHI-PUBLICLY-26111709, KAKENHI-PROJECT-26290022, KAKENHI-PROJECT-26670554, KAKENHI-PROJECT-26282145
[Journal Article] Preferred features of a fluorine-19 MRI probe foramyloid detection in the brain2014
- Author(s)
  Yanagisawa D, Taguchi H, Ibrahim NF, Morikawa S, Shiino A, Inubushi T, Hirao K, Shirai N, Sogabe T, Toovama I
- Journal Title
  
  J AIzhei mer's Dis
  
  Volume: 39 Issue: 3 Pages: 617-631
- DOI
  10.3233/jad-131025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153, KAKENHI-PROJECT-23300188, KAKENHI-PUBLICLY-24111522, KAKENHI-PROJECT-24240020, KAKENHI-PROJECT-24240071, KAKENHI-PROJECT-25750159
[Journal Article] 核磁気共鳴画像によるアミロイドイメージング用トレーサー2011
- Author(s)
  遠山育夫, 田口弘康、柳沢大治郎
- Journal Title
  
  鳥取医療
  
  Volume: 4 Pages: 68-74
- NAID
  40019763907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] Curcuminoid binds to amyloid β (1-42) oligomer and fibril2011
- Author(s)
  柳沢大治郎
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 24 Supplement2 Issue: s2 Pages: 33-42
- DOI
  10.3233/jad-2011-102100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J07718, KAKENHI-PROJECT-22300153
[Journal Article] Curcuminoid binds to amyloid β(1-42) oligomer and fibril.2011
- Author(s)
  Yanagisawa H, Taguchi H, Yamamoto A, Shirai N, Hirao K, Tooyama I
- Journal Title
  
  J Alzheimers Dis
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] In vivo detection of amyloid β deposition using 19F magnetic resonance imaging with a 19F-containing curcurain derivative in a mouse model of Alzheimer's disease2011
- Author(s)
  柳沢大治郎
- Journal Title
  
  Neuroscience
  
  Volume: 184 Pages: 120-127
- DOI
  10.1016/j.neuroscience.2011.03.071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J07718, KAKENHI-PROJECT-22300153, KAKENHI-PROJECT-22659171, KAKENHI-PLANNED-23111002, KAKENHI-PROJECT-23300131
[Journal Article] Relationship between the tautomeric structures of curcumin derivatives and their A β-binding activities in the context of therapies for Alzheimer's disease.2010
- Author(s)
  Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Kato M, Kato F, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Wada Y, Wada K N, Yamamoto A, Tooyama I
- Journal Title
  
  Biomaterials
  
  Volume: 31 Pages: 4179-4185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300153
[Journal Article] 動物モデルを使った高磁場MRIによる認知症診断の可能性2009
- Author(s)
  遠山育夫, 田口弘康, 雨坪知音, 森川茂廣
- Journal Title
  
  Cognition and Dementia 8
  
  Pages: 53-57
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19) F magnetic resonance imaging.2009
- Author(s)
  Amatsubo T, Morikawa S, Inubushi T, Urushitani M, Taguchi H, Shirai N, Hirao K, Kato M, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Tooyama I.
- Journal Title
  
  Neurosci Res. 63
  
  Pages: 76-81
- NAID
  10027499428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using 19F magnetic resonance imaging2009
- Author(s)
  Amatsubo T, Morikawa S, Matsuda K, Inubushi T, Urushitani M, Taguchi H, Shirai N, Hirao K, Kato M, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Tooyama I
- Journal Title
  
  Neurosci Res 63
  
  Pages: 76-81
- NAID
  10027499428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] The MR tracking of ATDC5 cells using fluorinated poly-L-Lysine-CF3.2007
- Author(s)
  Maki J, Masuda C, Morikawa S, Morita M, Inubushi T, Matsusue Y, Taguchi H, Tooyama I.
- Journal Title
  
  Biomaterials 28
  
  Pages: 434-440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Amyloid Imaging Using High-Field Magnetic Resonance
- Author(s)
  Amatsubo T, Morikawa S, Taguchi H, Tooyama I
- Journal Title
  
  Magn Resn Med Sci (in press)
- NAID
  10027851175
- Data Source
  KAKENHI-PROJECT-19300158
[Journal Article] Amyloid Imaging Using High-Field Magnetic Resonance
- Author(s)
  Tomone Amatsubo, Shigehiro Morikawa, Hiroyasu Taguchi, Ikuo Tooyama
- Journal Title
  
  Magn Resn Med Sci (in press)
- NAID
  10027851175
- Data Source
  KAKENHI-PROJECT-19300158
[Patent] アミロイドオリゴマーの画像診断薬2020
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎、加藤智子
- Industrial Property Rights Holder
  遠山育夫、田口弘康、柳沢大治郎、加藤智子
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-033405
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19K12780
[Patent] 神経難病の画像診断薬及び体外診断薬2017
- Inventor(s)
  田口弘康、遠山育夫, 柳沢大治郎、曾我部孝行、白井伸明、平尾浩一
- Industrial Property Rights Holder
  田口弘康、遠山育夫, 柳沢大治郎、曾我部孝行、白井伸明、平尾浩一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-046350
- Filing Date
  2017-03-10
- Data Source
  KAKENHI-PROJECT-15K01282
[Patent] 神経難病の画像診断薬及び体外診断薬2017
- Inventor(s)
  遠山育夫, 田口弘康、柳沢大治郎、曾我部孝行、白井伸明、平尾浩一
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-046350
- Filing Date
  2017-03-10
- Data Source
  KAKENHI-PROJECT-26290022
[Patent] 神経難病のMR画像診断薬2014
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Type
  特許
- Filing Date
  2014-01-06
- Overseas
- Data Source
  KAKENHI-PROJECT-22300153
[Patent] 神経難病のMR画像診断薬2013
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-202531
- Filing Date
  2013-09-27
- Data Source
  KAKENHI-PROJECT-22300153
[Patent] 神経難病のMR画像診断薬2013
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  滋賀医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-001948
- Filing Date
  2013-01-09
- Data Source
  KAKENHI-PROJECT-22300153
[Patent] 神経難病のＭＲ画像診断薬2013
- Inventor(s)
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Holder
  遠山育夫、田口弘康、柳沢大治郎
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-202531
- Filing Date
  2013-09-27
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Amyloid-β Oligomer Transition Evaluated through Electrophoresis and Atomic Force Microscopy with Histogram Analysis2022
- Author(s)
  Atsuya Matsui, Jean-Pierre Bellier, Hiroyasu Taguchi, Nobuyasu Naruse, and Yutaka Mera
- Organizer
  The 22nd International Vacuum Congress (IVC-22)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05207
[Presentation] Curcuminoids-induced Amyloid-β disassembly assessed by electrophoresis and AFM2021
- Author(s)
  A. Matsui, J. P. Bellier, H. Taguchi, N. Naruse and Y. Mera
- Organizer
  29th International Colloquium on Scanning Probe Microscopy (ICSPM29)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05207
[Presentation] フッ素MRIによるアミロイドβ・タウ病理の画像化研究2021
- Author(s)
  柳沢大治郎, 田口弘康, 遠山育夫
- Organizer
  第40回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19K12780
[Presentation] Threshold Concentration of Alcohol Affecting Amyloid-β1-42 Oligomeric Structures2020
- Author(s)
  A. Matsui , H. Satooka , H. Taguchi , N. Naruse , Y. Mera
- Organizer
  International Colloquium on Scanning Probe Microscopy (ICSPM28)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05207
[Presentation] Effect of Curcuminoid on Structure of Amyloid-β1-42 Oligomers2019
- Author(s)
  T. Kanai, H. Taguchi, N. Naruse and Y. Mera
- Organizer
  27th International Colloquium on Scanning Probe Microscopy (ICSPM27)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05207
[Presentation] タウ遺伝子改変マウスrTg4510のタウ蓄積における遺伝的背景の影響2019
- Author(s)
  柳沢大治郎、Hamizah Shahirah Hamezah、Aslina Pahrudin Arrozi、田口弘康、遠山育夫
- Organizer
  第42回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K12780
[Presentation] Therapeutic effects of a curcumin derivative Shiga-Y5 in the brain of a mouse model of Alzheimer’s disease2019
- Author(s)
  柳沢大治郎、田口弘康、遠山育夫
- Organizer
  The 13th Japan-China Joint Seminar on Histochemistry and Cytochemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12780
[Presentation] Fluorine-19 magnetic resonance imaging to detect tau pathology in rTg4510 mice2018
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  第18回国際薬理学・臨床薬理学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] etection of abnormal protein accumulation in Alzheimer’s disease using magnetic resonance imaging2018
- Author(s)
  Daijiro Yanagisawa, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  第５回モンゴル神経科学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] F-methyl-curcumin-1 (Shiga-Y5) はアルツハイマー病の画像診断や治療の候補化合物である2018
- Author(s)
  遠山育夫、柳沢大治郎、田口弘康
- Organizer
  第45回日本脳科学会
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] F-methyl-curcumin-1 is a potential diagnostic and therapeutic agent for Alzheimer's disease2017
- Author(s)
  Ikuo Tooyama, Anarmaa Mendsaikhan, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  第４回モンゴル神経科学会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] In vivo detection of tau pathology by fluorine-19 MR imaging in a mouse model of tauopathy2017
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  Alzheimer's Association International Conference 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] Application of double MR imaging for analysis of multiple pathological proteins in the brain of transgenic mouse model of Alzheimer’s disease.2017
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi
- Organizer
  第44回日本脳科学会総会
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] In vivo detection of tau pathology by fluorine-19 MR imaging in a mouse model of tauopathy.2017
- Author(s)
  aijiro Yanagisawa, Nor Faeizah Ibrahim, Hiroyasu Taguchi, Shigehiro Morikawa, Ikuo Tooyama
- Organizer
  第12回日本分子イメージング学会
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] フッ素MRIによるタウ病変のイメージング2017
- Author(s)
  柳沢大治郎、田口弘康、森川茂廣、遠山育夫
- Organizer
  第36回日本認知症学会総会
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] アルツハイマー病の病態解明のためのフッ素MRIによるダブルプローブイメージング法の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第11回日本分子イメージング学会
- Place of Presentation
  神戸
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Development on Shiga-Y, a potential diagnostic and therapeutic agent for Alzheimer's disease, using mouse model of dementia2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Tomoko, Kato, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Hiroyasu Taguchi
- Organizer
  第31回SAMサテライト国際シンポシウム
- Place of Presentation
  京都
- Year and Date
  2016-07-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] ッ素MR画像化法によるAβオリゴマーの検出の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] pplication of double MR imaging to detect amyloid oligomers in the brain of APP/PS1 transgenic model mice.2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Tomoko Kato, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  Alzheimer's Association International Conference 2016
- Place of Presentation
  トロント、カナダ
- Year and Date
  2016-07-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] A novel curcumin derivative, f-methyl-curcumin-1 (fmec1), is a potential diagnostic and therapeutic agent for Alzheimer's disease.2016
- Author(s)
  Tooyama, D. Yanagisawa, N. F. Ibrahim, H. Taguchi
- Organizer
  14th Meeting of Asia-Pacific Society for Neurochemistry
- Place of Presentation
  クアラルンプール、マレーシア
- Year and Date
  2016-07-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] -methyl-curcumin-1 is a potential diagnostic and therapeutic agent for Alzheimer's disease.2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Tomoko Kato, Shieghiro Morikawa
- Organizer
  第57回日本神経学会総
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Application of double MR imaging to detect amyloid oligomers in the brain of APP/PS1 transgenic model mice2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Tomoko Kato, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  Alzheimer's Association International Conference 2016
- Place of Presentation
  トロント、カナダ
- Year and Date
  2016-07-22
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] アルツハイマー病の病態解明のためのフッ素MRIによるダブルプローブイメージング法の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第11回日本分子イメージング学
- Place of Presentation
  神戸
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] フッ素MR画像化法によるAβオリゴマーの検出の開発2016
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫:
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2016-07-20
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] F-methyl-curcumin-1 is a potential diagnostic and therapeutic agent for Alzheimer's disease.2016
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Tomoko Kato, Shieghiro Morikawa
- Organizer
  第57回日本神経学会総会
- Place of Presentation
  神戸
- Year and Date
  2016-05-18
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] Effects of Novel Curcumin Derivative with C-4 Substituent on Cognitive Impairment and Amyloid Deposition in Appswe/PS1dE9 Mice.2015
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, and Ikuo Tooyama
- Organizer
  アルツハイマー協会国際会議(AAIC）2015
- Place of Presentation
  米国ワシントンＤＣ
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Styrylbenzoxazole and curcumin derivatives that have preferred features of a fluorine-19 MRI probe for amyloid imaging.2015
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  国際分子イメージング学会2015
- Place of Presentation
  米国ホノルル市
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Effect of novel curcumin derivatives on amyloid aggregation and the cell toxicity2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、Lina Wati Durani、Hamizah Shahirah Hamezah、田口弘康、遠山育夫
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸市
- Year and Date
  2015-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Effect of novel curcumin derivatives on amyloid aggregation and the cell toxicity.2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、Lina Wati Durani、Hamizah Shahirah Hamezah、田口弘康、遠山育夫
- Organizer
  第38回日本神経科学大会
- Place of Presentation
  神戸市
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] Effects of Novel Curcumin Derivative with C-4 Substituent on Cognitive Impairment and Amyloid Deposition in Appswe/PS1dE9 Mice.2015
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Hiroyasu Taguchi, Shigehiro Morikawa, Koichi Hirao, Nobuaki Shirai, and Ikuo Tooyama
- Organizer
  アルツハイマー病協会国際会議(AAIC)2015
- Place of Presentation
  米国ワシントンDC
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] フッ素MRIを利用したAβオリゴマーの画像化法の開発2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第10回日本分子イメージング学会総会
- Place of Presentation
  東京
- Year and Date
  2015-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Styrylbenzoxazole and curcumin derivatives that have preferred features of a fluorine-19 MRI probe for amyloid imaging.2015
- Author(s)
  Ikuo Tooyama, Daijiro Yanagisawa, Hiroyasu Taguchi, Nor Faeizah Ibrahim, Lina Wati Durani, Hamizah Shahirah Hamezah, Koichi Hirao, Nobuaki Shirai, Takayuki Sogabe, Shigehiro Morikawa
- Organizer
  国際分子イメージング学会2015
- Place of Presentation
  米国ホノルル市
- Year and Date
  2015-09-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] フッ素MRIを利用したAβオリゴマーの画像化法の開発2015
- Author(s)
  柳沢大治郎、Nor Faeizah Ibrahim、田口弘康、森川茂廣、遠山育夫
- Organizer
  第10回日本分子イメージング学会総会
- Place of Presentation
  東京
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-15K01282
[Presentation] クルクミン誘導体によるAβ凝集抑制効果とAβによる細胞障害軽減効果の解析2014
- Author(s)
  柳沢大治郎、遠山育夫、Ibrahim, Nor Faeizah、田口弘康
- Organizer
  第11回サプリメント研究会
- Place of Presentation
  東京、日本
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] アルツハイマー病画像診断を目的とした19F MRIによる脳内アミロイド斑の検出（その2）2013
- Author(s)
  Yanagisawa D, Morikawa S, Taguchi H, Shiino A, Inubushi T, Ibrahim NF, Tooyama I
- Organizer
  第36回日本神経科学会学術大会（Neuro2013）
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] アルツハイマー・病画像診断を目的とした19F MRIによる脳内アミロイド斑の検出(その2)2013
- Author(s)
  Yanagisawa D, Morikawa S, Taguchi H, Shiino A,Inubushi T, Ibrahim NF, Toovama I
- Organizer
  第36回日本神経科学会学術大会(Neuro2013)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain2013
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Inubushi T, Ibrahim NF, Hirao K, Shirai N, Sogabe T, Toovama I
- Organizer
  第15回国際アルツハイマー病会議(AAIC2013)
- Place of Presentation
  米国ボストン市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain.2013
- Author(s)
  Yanagisawa D, Taguchi H, Morikawa S, Inubushi T, Ibrahim NF, Hirao K, Shirai N, Sogabe T, Tooyama I
- Organizer
  第15回国際アルツハイマー病会議 (AAIC2013)
- Place of Presentation
  米国ボストン
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Curcumin binding activity to B-amyloid oligomer2011
- Author(s)
  Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Wada Y, Wada K, Yamamoto A, Tooyama I
- Organizer
  第13回国際アルツハイマー病会議(ICAD2011)
- Place of Presentation
  フランスパリ市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] アルツハイマー病画像診断を目的とした19F MRIによる脳内アミロイドの検出2011
- Author(s)
  柳沢大治郎、森川茂廣、田口弘康、椎野顕彦、犬伏俊郎、遠山育夫
- Organizer
  第34回日本神経科学会学術大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Curcumin binding activity to ss-amyloid oligomer2011
- Author(s)
  Yanagisawa D, Shirai N, Amatsubo, T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Wada Y, Wada K, Yamamoto A, Tooyama I
- Organizer
  第13回国際アルツハイマー病会議(ICAD2011)
- Place of Presentation
  フランスパリ市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Curcumin derivatives for amyloid detection using 19F magnetic resonance imaging2011
- Author(s)
  Taguchi H, Yanagisawa D, Morikawa S, Shiino A, Inubushi T, Hirao K, Shirai N, Tooyama I
- Organizer
  第13回国際アルツハイマー病会議(ICAD2011)
- Place of Presentation
  フランスパリ市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] アルツハイマー病画像診断を目的とした19F MRIによる脳内アミロイドの検出2011
- Author(s)
  柳沢大治郎、森川茂廣、田口弘康、椎野顕彦、犬伏俊郎、遠山育夫
- Organizer
  第34回日本神経科学会学術大会(Neuro2011)
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] クルクミンのケトエノール互変異性とアミロイド親和性を利用したアルツハイマー病診断薬の検討2011
- Author(s)
  遠山育夫、柳沢大治郎、田口弘康
- Organizer
  第52回日本神経学会総会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Binding form of curcumin derivatives to B-amyloid aggregates2010
- Author(s)
  Ynagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Wada Y, Wada K, Yamamoto A, Tooyama I
- Organizer
  第12回国際アルツハイマー病会議(ICAD2010)
- Place of Presentation
  米国ホノルル市
- Data Source
  KAKENHI-PROJECT-22300153
[Presentation] Interaction of the brain tissues with trifluoromethoxy-benzylated ligands for amyloid detection using 19F magnetic resonance imaging2008
- Author(s)
  Tomone Amatsubo, Shigehiro Morikawa, Keiko Matsuda, Toshiro Inubushi, Makoto Urushitani, Hiroyasu Taguchi, Nobuaki Shirai, Koichi Hirao, Masanari Kato, Kyuya Morino, Hirohiko Kimura, Ichiro Nakano, Chikako Yoshida, Takashi Okada, Mitsuo Sano, Ikuo Tooyama
- Organizer
  第10回国際アルツハイマー病会議(ICAD2008)
- Place of Presentation
  米国シカゴ市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] Bezoxazol derivatives containing trifluoromethoxy-benzyl amino group for amyloid detection in APP transgenic mice using ^<19>F magnetic resonance imaging2008
- Author(s)
  H Taguchi, T Amatsubo, S Morikawa, K Matsuda, N Shirai, K Hirao, M Kato, HMorino, H Kimura, I Nakano, C Yoshida, T Okada, MSano, I Tooyama
- Organizer
  第11回国際アルツハイマー病会議(ICAD2008)
- Place of Presentation
  米国シカゴ市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] Trifluoromethoxy-benzylated化合物と脳組織の相互作用による19Fシグナル強度の変化2008
- Author(s)
  雨坪知音、森川茂廣、松田敬子、田口弘康、白井伸明、平尾浩一、遠山育夫
- Organizer
  第3回日本分子イメージング学会総会・学術集会
- Place of Presentation
  さいたま市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] MR tracking of transplanted neural cells using fluorinated poly-L-lysine-CF32007
- Author(s)
  Makoto Urushitani, Chiaki Masuda, Hiroyasu Taguchi, Shigehiro Morikawa, Toshiro Inubushi, Nobuaki Shirai, Koichi Hirao, Ikuo Tooyama
- Organizer
  第37回北米神経科学会議(Neuro2007)
- Place of Presentation
  米国サンディエゴ市
- Data Source
  KAKENHI-PROJECT-19300158
[Presentation] Novel curcumin derivative with C-4 substituent inhibits amyloid pathology in APPswe/PS1dE9 mice
- Author(s)
  Yanagisawa D, Taguchi H, Ibrahim NF, Durani L, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I
- Organizer
  北米神経科学会議（Neuro2014)
- Place of Presentation
  ワシントンDC、米国
- Year and Date
  2014-11-15 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-26290022
[Presentation] Effect of novel curcumin derivatives on amyloid pathology in APP/PS1 mice
- Author(s)
  Daijiro Yanagisawa, Nor Faeizah Ibrahim, Lina Wati Durani, Hiroyasu Taguchi, Ikuo Tooyama
- Organizer
  第37回日本神経科学学会学術大会
- Place of Presentation
  横浜市、日本
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26290022

1. TOOYAMA Ikuo (20207533)

# of Collaborated Projects: 4 results

# of Collaborated Products: 58 results
2. INUBUSHI Toshiro (20213142)

# of Collaborated Projects: 2 results

# of Collaborated Products: 17 results
3. Naruse Nobuyasu (30350408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 椎野顯彦 (50215935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 柳沢大治郎 (50581112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
6. 加藤智子 (90754367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Morikawa Shigehiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
8. KURUMI Yosimasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 北田容章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 平井慎一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. BELLIER Jean-Pierre

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAGUCHI Hiroyasu 田口 弘康

田口 弘康 タグチ ヒロヤス

Research Projects

Research Products

Co-Researchers

Microscopic analysis of amyloid beta oligomers to elucidate the function of candidate medicinal agents for Alzheimer's disease

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Development of novel ligands for in vivo imaging of amyloid oligomers in the brain of Alzheimer's diseasePrincipal Investigator

Principal Investigator

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Development novel probes for fluorine MRI to detect neurodegenerative diseasesPrincipal Investigator

Principal Investigator

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Research Institution

Development of novel diagnostic and therapeutic methods on Alzheimer's disease by targeting amyloid oligomers

Principal Investigator

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Research Institution

Development of amyloid imaging using fluorine-MRI

Principal Investigator

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Research Institution

Development of diagnostic methods for Parkinson disease using high fieled magnetic resonance imaging

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[Book] FRUITS, VEGETABLES AND HERBS: Bioactive Foods in Health Promotion2017

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[Book] FRUITS, VEGETABLES AND HERBS: Bioactive Foods in Health Promotion2016

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[Journal Article] The Effect of Ethanol on Disassembly of Amyloid-β1-42 Pentamer Revealed by Atomic Force Microscopy and Gel Electrophoresis2022

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibrils2021

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NAID

Data Source

[Journal Article] A Fluorine-19 Magnetic Resonance Probe, Shiga-Y5, Downregulates Thioredoxin-Interacting Protein Expression in the Brain of a Mouse Model of Alzheimer’s Disease2021

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Journal Title

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[Journal Article] Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer’s Disease2021

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DOI

NAID

Data Source

[Journal Article] Novel fluorinated derivative of curcumin negatively regulates thioredoxin-interacting protein expression in retinal pigment epithelial and macrophage cells2020

Author(s)

Journal Title

DOI

NAID

TAGUCHI Hiroyasu 田口弘康

田口弘康タグチヒロヤス

[Journal Article] Novel curcumin derivatives as potent inhibitors of amyloid ß aggregation.2015