HIRABAYASHI Yoshio 平林義雄

… Alternative Names

Researcher Number	90106435
External Links
Affiliation *help	2018 : 国立研究開発法人理化学研究所, 開拓研究本部, 客員主管研究員 2016 – 2017 : 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー 2016 : 国立研究開発法人理化学研究所, 脳科学総合研究センター・神経膜機能研究チーム, シニアチームリーダー 2013 : 独立行政法人理化学研究所, 脳科学総合研究センター, チームリーダー 2012 : 独立行政法人理化学研究所, 神経膜機能研究チーム, チームリーダー … More
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological Sciences / Structural biochemistry / Structural biochemistry / 物質生物化学 Except Principal Investigator General medical chemistry / 物質生物化学 / Science and Engineering / Dermatology / Functional biochemistry / Biological Sciences / Chemistry / Functional biochemistry
Keywords	Principal Investigator ガングリオシド / シアル酸 / スフィンゴ脂質 / プルキンエ細胞 / グルコシルセラミド / ニューロン / 糖脂質 / 分化抗原 / Ganglioside / 単クロ-ン抗体 … More Except Principal Investigator 糖脂質 / セラミド / アポトーシス / グルコシルセラミド / Oncogene / インターロイキン3 / 糖タンパク質 / Angiokeratoma / hydrogen peroxide / 脳神経 / G蛋白質 / 脂質メタボローム / 糖質関連化学・糖鎖工学 / 肥満 / 気相分離 / 糖鎖末端ガラクトース / 固相抽出 / 親水性相互作用クロマトグラフィー / alpha-N-acetylgalactosaminidase / リン作動性ニユーロン特異的ガングリオシド / スフィンゴシンキナーゼ / apoptosis / 発癌遺伝子 / アポートシス / 細胞分化 / 過酸化水素 / 分化抗原 / ライソゾーム蓄積症 / α-N-アセチルガラクトースアミニデース / 脂質 / 神崎病 / 蛋白質 / 細胞内脂質輸送 / 癌遺伝子 / 小胞体 / ceramide / 生体分子 / グルコース化脂質 / 糖鎖コア構造 / シンドラ-病 / 細胞増殖因子IL-3 / Monoclonal antibody / びまん性体幹被角血管腫 / Developmental Antigen / シアル酸転移酵素 / ウイルスレセプタ- / ガングリオシドM5 / モノクロナ-ル抗体 / 腎疾患 / 神経変性疾患 / スフィンゴ脂質合成阻害剤 / Cell Membranes / 細胞膜 / アフィテニティクロマトグラフィー / αーNーアセチルガラクトサミニデ-ス / Kanzaki disease / 遺伝子解析 / スフィンゴシン1-リン酸 / シアル酸 / 糖 / Virus Receptor / glucosylceramide / Cell Differentiation / N-アセチルガラクトサミニル化 / Schindler disease / 細胞膜ミクロドメイン / スフィンゴ脂質 / 被角血管腫 / Point mutation / GM1合成酵素 / アセチル転移酵素 / 異性体分離 / 神経新生 / ARIS硫酸化糖鎖構造 / シグナル伝達 / ガングリオシド / ポリシアロガングリオシド / ポイントミュ-テ-ション / Ganglioside / 脂質メタボローム解析 / 受精先体反応 / スフィンゴシン1 リン酸 / 分化 / プロモーター / ライソゾ-ム蓄積症 / 癌関連糖脂質 / ポイントミューテーション / グリア系細胞 / GD3合成酵素 / ウイルス / グルコシル転移酵素 / 糖蛋白糖鎖末端シアル酸 / GM3合成酵素 / Lysosomal storage disease / グルコース転移酵素 / カルモジュリン依存性酵素 / ガングリオシド抗体 / イオンモビリティーシステム / 糖脂質完全欠損ミュータント細胞 / 発癌 / 糖転移酵素 / 遺伝子 / ライソゾーム畜積症 / 糖脂質の末端シアル酸化 / Sialic acid / 精子受容体活性 / シンドラー病 / Molecular analysis / 発生 / ノックアウトマウス / アセチルCoAトランスポーターアセチル Less

Chemical Biology of ER Related Glycan ModificationsOngoing
- Principal Investigator
  
  伊藤幸成
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Science and Engineering
  Chemistry
- Research Institution
  Institute of Physical and Chemical Research
新規脳内糖化ステロール群の発見に基づくステロール代謝経路の再構築Principal InvestigatorOngoing
- Principal Investigator
  
  平林義雄
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Institute of Physical and Chemical Research
Development of glycosylated lipid metabolomics system for clarifying their neuronal function
- Principal Investigator
  
  Nakajima Kazuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Fujita Health University
  Institute of Physical and Chemical Research
新規グルコース化脂質分子による神経ガイダンス制御Principal Investigator
- Principal Investigator
  
  平林義雄
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Functional analysis of glycosphingolipids by molecular biological approaches
- Principal Investigator
  
  ICHIKAWA Shinichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Niigata University of Pharmacy and Applied life Sciences
スフィンゴ脂質による生体膜ドメイン形成と多機能シグナリング
- Principal Investigator
  
  五十嵐靖之
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
細胞の生存と死におけるスフィンゴ糖脂質の役割Principal Investigator
- Principal Investigator
  
  平林義雄
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
スフィンゴ糖脂質生合成酵素遺伝子の発現制御機構とその生物学的意義
- Principal Investigator
  
  ICHIKAWA Shinichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
Molecular characterization of membrane sphingolipid functionPrincipal Investigator
- Principal Investigator
  
  HIRABAYASHI Yoshio
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  The Institute of Physical and Chemical Research
スフィンゴ糖脂質による細胞膜極性の形成機構と生物機能の発現Principal Investigator
- Principal Investigator
  
  平林義雄
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Institute of Physical and Chemical Research
小脳プルキンエ細胞における可塑性分子機構と新規情報分子-スフィンゴ脂質-Principal Investigator
- Principal Investigator
  
  平林義雄
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The Institute of Physical and Chemical Research
Functioal analysis of polysialogangliosides expressed in the CNSPrincipal Investigator
- Principal Investigator
  
  HIRABAYASHI Yoshio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The Institute of Physical & Chemical Research
糖鎖と増殖・分化
- Principal Investigator
  
  斎藤政樹
- Project Period (FY)
  1993 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
  Jichi Medical University
New approaches of glyco-neurobiologyPrincipal Investigator
- Principal Investigator
  
  HIRABAYASHI Yoshio
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  The Institute of Chemical and Physical Research
神経系の発生初期に特異的に発現される新しいシアロ糖鎖抗原の機能と発現制御Principal Investigator
- Principal Investigator
  
  平林義雄
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The Institute of Physical and Chemical Research
A novel form of angiokeratoma corporis diffusum: Elucidatim of abnormal metabolites in urine and enzyme defect.
- Principal Investigator
  
  KANZAKI Tamotsu
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Kagoshima University
  Nagoya City University
Biochemical and molecular genetical studies on a new glycoprotein storage disorderPrincipal Investigator
- Principal Investigator
  
  HIRABAYASHI Yoshio
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
単クロ-ン抗体による神経系超微量ガングリオシドの構造と機能の解析Principal Investigator
- Principal Investigator
  
  平林義雄
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  University of Shizuoka
BIOLOGICAL FUNCTION OF GANGLIOSIDES
- Principal Investigator
  
  SUZUKI Yasuo
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  UNIVERSITY OF SHIZUOKA, SCHOOL OF PHARMACEUTICAL SCIENCE
Molecular mechanisms of expression of mouse melanoma-ganglioside antigensPrincipal Investigator
- Principal Investigator
  
  HIRABAYAHSI Yoshio
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Faculty of Pharmaceutical Science, University of Shizuoka
  Shizuoka College of Pharmacy

All 2016 2015 2014 2013 2012 2004

All Journal Article Presentation Book

[Book] 生体の科学、ホスファチジルグルコシドとそのリゾ体脂質の生物機能2016
- Author(s)
  長塚靖子、中嶋和紀、平林義雄
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-15K19016
[Journal Article] 脳における新たなステロール代謝経路：糖化ステロール群の発見2016
- Author(s)
  秋山央子，平林義雄
- Journal Title
  
  JSBMS Letters
  
  Volume : 41 Pages : 43-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14687
[Journal Article] Aglycon diversity of brain sterylglucosides:Structure determination of cholesteryl- and sitosterylglucoside.2016
- Author(s)
  Akiyama H, Nakajima K, Itoh Y, Sayano T, Ohashi Y, Yamaguchi Y, Greimel, P, Hirabayashi Y.
- Journal Title
  
  J. Lipid. Res.
  
  Volume : 57 Pages : 2061-72
- DOI
  10.1194/jlr.M071480
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-15K19016, KAKENHI-PROJECT-26860199, KAKENHI-PROJECT-16K14687
[Journal Article] Separation and analysis of mono-glucosylated lipids in brain and skin by hydrophilic interaction chromatography based on carbohydrate and lipid moiety.2016
- Author(s)
  Nakajima K, Akiyama H, Tanaka K, Kohyama-Koganeya A, Greimel P, Hirabayashi Y.
- Journal Title
  
  J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
  
  Volume : 1031 Pages : 146-53
- DOI
  10.1016/j.jchromb.2016.07.047
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02540, KAKENHI-PROJECT-15K19016, KAKENHI-PROJECT-26860199
[Journal Article] Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant alpha-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.2015
- Author(s)
  Suzuki M, Fujikake N, Takeuchi T, Kohyama-Koganeya A, Nakajima K, Hirabayashi Y, Wada K, Nagai Y.
- Journal Title
  
  Hum Mol Genet
  
  Volume : 24 Pages : 6675-6686
- DOI
  10.1093/hmg/ddv372
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19016, KAKENHI-PROJECT-15K19502, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-26670446, KAKENHI-PROJECT-26713030
[Journal Article] あらたなグルコース化脂質の存在と役割2014
- Author(s)
  秋山　央子、平林　義雄
- Journal Title
  
  医学のあゆみ
  
  Volume : 248 (13) Pages : 1031-1036
- Data Source
  KAKENHI-PUBLICLY-24110519
[Journal Article] New insights on glucosylated lipids : metabolism and functions2013
- Author(s)
  Ishibashi Y, Kohyama-Koganeya A, Hirabayashi Y
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume : 1831 (9) Pages : 1475-1485
- DOI
  10.1016/j.bbalip.2013.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24110519, KAKENHI-PROJECT-24770198
[Journal Article] Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality.2004
- Author(s)
  Hirabayashi Y.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages : 3573-3577
- Data Source
  KAKENHI-PROJECT-12140101
[Presentation] パーキンソン病に関与する新規脳内糖化ステロールの発見2016
- Author(s)
  秋山央子、中嶋和紀、伊藤喜之、佐矢野智子、長塚靖子、大橋陽子、山口芳樹、Peter Greimel、平林義雄
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  にぎわい交流館AU (秋田県・秋田市)
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-16K14687
[Presentation] パーキンソン病発症因子・酸性グルコシルセラミド分解酵素GBA1の新規糖脂質代謝産物の発見2016
- Author(s)
  秋山央子、中嶋和紀、伊藤喜之、佐矢野智子、長塚靖子、大橋陽子、山口芳樹、Peter Greimel、平林義雄
- Organizer
  第35回日本糖質学会年会
- Place of Presentation
  高知市文化プラザかるぽーと (高知県・高知市)
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-16K14687
[Presentation] HILIC-MS/MSを用いたパーキンソン病に関与する新規脳内糖脂質の発見2016
- Author(s)
  秋山央子、中嶋和紀、伊藤喜之、佐矢野智子、長塚靖子、大橋陽子、山口芳樹、Peter Greimel、平林義雄
- Organizer
  第41回日本医用マススペクトル学会年会
- Place of Presentation
  ウインクあいち (愛知県・名古屋市)
- Year and Date
  2016-09-15
- Invited
- Data Source
  KAKENHI-PROJECT-16K14687
[Presentation] HILIC-ESI-MSによるグルコース化異性体の定性・定量分析とその臨床応用2016
- Author(s)
  中嶋和紀、秋山央子、長塚靖子、岩渕和久、高橋和男、湯澤由紀夫、平林義雄
- Organizer
  第41回医用マススペクトル会議年会
- Place of Presentation
  ウィンク愛知
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-15K19016
[Presentation] HILIC-ESI-MSによるグルコース化異性体の定性・定量分析とその臨床応用2016
- Author(s)
  中嶋和紀、秋山央子、長塚靖子、岩渕和久、高橋和男、湯澤由紀夫、平林義雄
- Organizer
  第35回日本糖質学会年会
- Place of Presentation
  高知市文化プラザかるぽーと
- Year and Date
  2016-09-15
- Data Source
  KAKENHI-PROJECT-15K19016
[Presentation] 新規脂質メタボローム解析技術を用いた微量グルコース化脂質の神経疾患・腎疾患における役割解明2016
- Author(s)
  中嶋和紀、秋山央子、長塚靖子、岩渕和久、高橋和男、湯澤由紀夫、平林義雄
- Organizer
  糖鎖科学中部拠点「第13回若手の力フォーラム」
- Place of Presentation
  岐阜大学応用生物科学部
- Year and Date
  2016-11-26
- Data Source
  KAKENHI-PROJECT-15K19016
[Presentation] HILIC-イオンモビリティ-MS/MSによるホスファチジルグルコシド代謝物の高感度・高選択的定量法2015
- Author(s)
  中嶋和紀、長塚靖子、中山仁志、岩渕和久、平林義雄
- Organizer
  第34回　日本糖質学会年会
- Place of Presentation
  東京大学安田講堂（文京区）
- Year and Date
  2015-07-31
- Data Source
  KAKENHI-PROJECT-15K19016
[Presentation] Biosynhtesis of cholesteryglucoside: role of glucosylceramide as glucose donor2014
- Author(s)
  Hisako Akiyama &　Yoshio Hirabayashi
- Organizer
  Goedon Research Conference
- Place of Presentation
  Montauk, New York
- Data Source
  KAKENHI-PUBLICLY-24110519
[Presentation] Glycolipids in neuron-glia interaction and neuropathological conditions2013
- Author(s)
  Yoshio Hirabayashi
- Organizer
  ISN-ASN SATELLITE SYMPOSIUM: Unveiling the Significance of Lipid Signaling in Neurodegeneration and Neuroprotection
- Place of Presentation
  Cancun, Mexico
- Data Source
  KAKENHI-PUBLICLY-24110519
[Presentation] A novel lyso-form glycolipid mediating cell-cell interaction2013
- Author(s)
  Yoshio Hirabayashi
- Organizer
  FASEB Science Research Conference (Lysophospholipid and Other Related Mediators - From Bench to Clinic)
- Place of Presentation
  Niseko
- Data Source
  KAKENHI-PUBLICLY-24110519
[Presentation] A novel bioactive lipid, phosphatidylglucoside: from structure to functions in the developing brain2012
- Author(s)
  Yoshio HIrabayashi
- Organizer
  Gordon Research Conferences, Glycolipid Sphingolipid Biology
- Place of Presentation
  Lucca(Barga), Iraly
- Year and Date
  2012-04-22
- Invited
- Data Source
  KAKENHI-PUBLICLY-24110519

1. FURUYA Shigeki (00222274)

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2. ICHIKAWA Shinichi (10223083)

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3. 金森審子 (00261173)

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4. KANZAKI Tamotsu (80118801)

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5. 長塚靖子 (70108497)

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6. MIZOGUCHI Tsugio (90133149)

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7. IRIE Fumitoshi (90291054)

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8. NAGANO Michiyo (80350718)

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9. SUZUKI Yasuo (00046278)

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13. Iwabuchi Kazuhisa (10184897)

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31. 三好一郎 (10183972)

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32. 竹田潤二 (50163407)

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33. 古金谷綾子(香山綾子) (70312270)

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34. 伊藤幸成 (80168385)

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35. 武田陽一 (20423973)

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36. 松尾一郎 (40342852)

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37. 梶原康宏 (50275020)

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38. 迫野昌文 (50391959)

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39. 井原義人 (70263241)

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40. 戸谷希一郎 (80360593)

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41. 三苫純也 (10281627)

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42. LI Yu-teh

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43. 小澤克也

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44. YUーTEH Li

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45. ISHIBASHI Yohei

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46. Suzuki Kyoko

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47. NAGAI Yoshitaka

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48. 鈴木マリ

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49. 鈴木道雄

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50. 武内敏秀

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HIRABAYASHI Yoshio 平林 義雄

平林 良雄 ヒラバヤシ ヨシオ

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Chemical Biology of ER Related Glycan ModificationsOngoing

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新規脳内糖化ステロール群の発見に基づくステロール代謝経路の再構築Principal InvestigatorOngoing

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Development of glycosylated lipid metabolomics system for clarifying their neuronal function

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新規グルコース化脂質分子による神経ガイダンス制御Principal Investigator

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Functional analysis of glycosphingolipids by molecular biological approaches

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スフィンゴ脂質による生体膜ドメイン形成と多機能シグナリング

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細胞の生存と死におけるスフィンゴ糖脂質の役割Principal Investigator

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スフィンゴ糖脂質生合成酵素遺伝子の発現制御機構とその生物学的意義

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Molecular characterization of membrane sphingolipid functionPrincipal Investigator

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スフィンゴ糖脂質による細胞膜極性の形成機構と生物機能の発現Principal Investigator

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小脳プルキンエ細胞における可塑性分子機構と新規情報分子-スフィンゴ脂質-Principal Investigator

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Functioal analysis of polysialogangliosides expressed in the CNSPrincipal Investigator

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糖鎖と増殖・分化

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HIRABAYASHI Yoshio 平林義雄

平林良雄ヒラバヤシヨシオ