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SHINKI Toshimasa  新木 敏正

ORCIDConnect your ORCID iD *help
Researcher Number 90138420
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2004 – 2006: Nihon Pharmaceutical University, Professor, 薬学部, 教授
1997 – 2003: School of Dentistry, Showa University, Lecturer, 歯学部, 講師
2000: 昭和大, 歯学部, 講師
1986 – 1995: 昭和大学, 歯学部, 講師
1992: Showa Univ., School of Dentistry Associate Professor, 歯学部, 構師
1986: 昭和大学, RIセンター, 講師
Review Section/Research Field
Principal Investigator
Functional basic dentistry / Biological pharmacy / Functional basic dentistry
Except Principal Investigator
Functional basic dentistry / Functional basic dentistry
Keywords
Principal Investigator
活性型ビタミンD / 副甲状腺ホルモン / 腎臓 / RT-PCR / 24-水酸化酵素 / ビタミンD / RANKL / トランスジェニック / 骨吸収 / kidney … More / 24-hydroxylase / 1alpha-hydroxylase / parathyroid hormone / ビタミンD受容体 / ネフロン / 1alpha, 25-dihydroxyvitamin D_3 / ODC / Proteomics / Vitamin D metabolism / Bone mineral / Transgenic / Parathyroid hormone / Vitamin D / Renal osteodystrophy / Kidney / 糖尿病 / 腎炎 / カルシトニン / 副甲状腺 / 石灰化 / プロテオミックス / ビタミンD代謝 / 骨量 / 腎性骨症 / Periodontal disease / Long bone / Bone mineral density / Bone resorption / alveolar bone / transgenic mice / Interleukin 1 / LPS / OPG / トランスジェニックマウス / ドライスカル / 口腔内細菌 / サイトカイン / 破骨細胞 / 歯根膜 / 歯周病 / 低カルシウム / インターロイキン-1 / 歯槽骨 / glomerulosclerosis / vitamin D binding protein / 25-hydroxyvitamin D_3 / transgenic rat / megalin / 24,25-dihydroxyvitamin D_3 / 1α,25-dihydroxyvitamin D_3 / 単状糸球体腎炎 / ビタミンD結合蛋白質 / 25-ヒドロキシビタミンD / メガリン / 巣状糸球体腎炎 / トランスジェニックラット / degenerate-PCR / vitamin D receptors / cytochrome P450 / proximal convoluted tubules / 近位尿細管 / シトクロムP450 / シトクロムP-450 / 1α-水酸化酵素 / mRNA / vitamin D receptor / vitamin D / カルシウム / vitamin D derivatives / triacylglycerol / preadipocyte / phospholipids / osteoporosis / adipogenesis / adipocyte / ホスファチジルコリン / 骨髄間質細胞 / 脂質代謝 / デキサメタゾン / 前脂肪細胞 / トリグリセリド / リン脂質 / 骨粗鬆症 / 脂質合成 / 脂肪細胞 / villus / Ca-ATPase / putrescine / polyamine / Ca transport / Intestine / ポリアミン酸化酵素 / CaーATPase / ポリアミン合成阻害剤 / プトレッシン / ポリアミン / Ca吸収 / 小腸 … More
Except Principal Investigator
破骨細胞 / 活性型ビタミンD / 骨芽細胞 / 骨吸収 / 副甲状腺ホルモン / カルシウム / osteoclast / OPG / RANKL / Osteoclast / RANK / ODF / カルシトニン / bone resorption / osteoblast / M-CSF / 細胞融合 / マクロファージ / Calcium / 骨誘導因子 / Osteoblast / OCIF / 骨粗鬆症 / bone marrow / 骨 / ビタミンD / インターロイキン6 / 腎臓 / 肝臓 / 1α,25(OH)_2D_3 / C3 / 1alpha, 25-Dihydroxyvitamin D_3 / マクロファ-ジ / ポリアミン / カルシウム吸収 / 補体第3因子 / PTH / Transglutaminase / Spermidine / Cell Fusion / Macrophage / トランスグルタミナ-ゼ / スペルミジン / osteoblasts / macrophage fusion factor (MFF) / differentiation-inducing factor (DIF) / 1alpha,25-dihydroxyvitamin D_3 [1alpha,25(OH)_2D_3 / コロニー形成因子(CSF) / 骨髄細胞 / マクロファージ融合因子(MFF) / マクロファージ融合因子 / 活性型ビタミンD_3(1α,25(OH)_2D_3) / 分化誘導因子(DIF) / Cell-fusion / Macrophages / Vitamin D / 多核巨細胞 / マクロファージの融合 / 骨吸収活性 / MGBG / LPS / DIF / OAF / トリグリセライド / 融合 / 肺胞マクロファージ / 分化誘導因子 / radicals / NADPH-oxidase / osteoarthritis / rheumatoid arthritis / cell death / synoviocytes / chondrocytes / nitric oxide / ネクローシス / ミトコンドリア / パーオキシナイトライト / スーパーオキサイド / インターロイキン-1 / 軟骨 / 生理活性 / 生体分子 / ストレス / シグナル伝達 / 細胞・組織 / ラジカル / NADPH-oxdiase / 変形性関節症 / 関節リウマチ / 細胞死 / 滑膜細胞 / 軟骨細胞 / 一酸化窒素 / CELL DIFFERENTIATION / MYOBLAST / OSTEOBLAST / BONE MORPHOGENETIC PROTEIN / GROWTH FACTOR / HORMONE / TRANSCRIPTION FACTOR / BONE FORMATION / 受容体 / 血清 / 転写調節因子 / 筋芽細胞 / 細胞分化 / 成長因子 / ホルモン / 骨形成 / Osteoporosis / BMP / Inflammatory cytokines / 細胞内Ca / IL-1 / TNFα / 炎症性サイトカイン / 1α, 25(OH)_2D_3 / TNF / Bone resorption / マクロファジーコロニー刺激因子 / 骨随間質細胞 / 遺伝子欠損マウス / 破骨細胞形成抑制因子 / 破骨細胞分化因子 / 1α-hydroxylase / 1α,25-dihydroxyvitamin D3 / parathyroid hormone / ステロイドホルモン / 1α-水酸化酵素 / hemopoiesis / osteoporosis / interleukin-6 / interleukin-1 / androgen / estrogen / プロスタグランジン / アンドロゲン / Bリンパ球 / 骨髄造血 / インターロイキン1 / エストロゲン / bone / macrophage / vitamin D / stromal cells / complement 3 / C3遺伝子 / 補体第3因子(C3) / ビタミンD欠乏 / 骨髄ストローマ細胞 / 転写調節 / interleukin 11 / interleukin 6 / gp130 / calcium absorption / 1alpha, 25(OH)_2D_3 / 24,25(OH)_2D_3 / ビタミンDレセプター / インターロイキン11 / 小腸 / 抗クル病因子 / 1alpha,25(OH)_2D_3 / C3 receptor / complement / ILー1 / 116kD / 骨髄間質細胞 / マウス補体第3成分 / C3レセプター / 補体第3成分 / Growth factor / Bone resorbing agents / the third component of complement (C3) / Calcium pump / Osteoclasts / Osteoblasts / Intestine epithelial cells / マクロファ-ジコロニ-刺激因子 / 小腸上皮細胞細胞 / オステオポンチン / 増殖因子 / 骨吸収因子 / カルシウムポンプ / 小腸の吸収上皮細胞 / ヒト破骨細胞 / ヒト抹消血 / 共存培養 / ヒト抹消血単核細胞 / PTHレセプター / 破骨細胞分子因子(ODF) / SaOS-2 Less
  • Research Projects

    (21 results)
  • Research Products

    (3 results)
  • Co-Researchers

    (20 People)
  •  Evidence base treatment of renal osteodistropyPrincipal Investigator

    • Principal Investigator
      SHINKI Toshimasa
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Nihon Pharmaceutical University
  •  On the regulation of survival and death of synoviocytes and chondrocytes by nitric oxide

    • Principal Investigator
      MIYAMOTO Yoichi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  Mechanisms of bone resorption in alveolar bone of IL-1 transgenic micePrincipal Investigator

    • Principal Investigator
      SHINKI Toshimasa
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Nihon Pharmaceutical University
      Showa University
  •  CHARACTERIZATION OF THE BONE FORMING FACTORS IN SERUM

    • Principal Investigator
      KATAGIRI Takenobu
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      SHOWA UNIVERSITY
  •  Role of Vitamin D hydroxylase on Bone Metabolism.Principal Investigator

    • Principal Investigator
      SHINKI Toshimasa
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  The physiological role of osteoclast differentiation factor.

    • Principal Investigator
      UDAGAWA Nobuyuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  Study on signal transduction in osteoclastogenesis for the development of anti-osteoporosis drugs.

    • Principal Investigator
      TAKAHASHI Naoyuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  The roles of nuclear transcription factors in calcium homeostasis

    • Principal Investigator
      SUDA Tatsuo
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  ヒトPTH受容体遺伝子の導入によるヒト破骨細胞形成系の確立

    • Principal Investigator
      SUDA Tatsuo
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  Mechanism of regulation of vitamin D metabolism at molecular level.Principal Investigator

    • Principal Investigator
      SHINKI Toshimasa, 新木 敏正
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  Molecular mechanisms of osteoporosis induced by estrogen deficiency.

    • Principal Investigator
      SUDA Tatsuo
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  Role of vitamin D and parathyroid hormone on vitamin D metabolism in the kidney.Principal Investigator

    • Principal Investigator
      SHINKI Toshimasa
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  Production and biological roles of the third component of complement in bone.

    • Principal Investigator
      MIYAURA Chisato
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  Molecular aspects of vitamin D metabolism and action

    • Principal Investigator
      SUDA Tatsuo
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  Cloning of proteins produced by osteoblastic cells in response to 1alpha,25(OH)_2D_3.

    • Principal Investigator
      ABE Etsuko
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  Role of vitamin D_3 on differentiation of bone marrow-derived stromal cells.Principal Investigator

    • Principal Investigator
      SHINKI Toshimasa
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  Basic study on the risk factors of osteoporosis.

    • Principal Investigator
      SUDA Tatsuo
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  Role of Putrescine in Vitamin D-Dependent Intestinal Cell Differentiation.Principal Investigator

    • Principal Investigator
      SHINKI Toshimasa
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  Two step model for the fusion of macrophages induced by 1alpha, 25-dihydroxyvitamin D_3

    • Principal Investigator
      SUDA Tatsuo
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University
  •  Development of new assay systems for examining the relation between osteoblasts and osteoclasts, and identification of new factors controlling bone metabolism

    • Principal Investigator
      SUDA Tatsuo
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University, School of Dentistry
  •  Mechanisms of Fusion of Macrophages Induced by 1 ,25(OH)_2D_3

    • Principal Investigator
      SUDA Tatsuo
    • Project Period (FY)
      1985 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Functional basic dentistry
    • Research Institution
      Showa University

All 2006

All Book

  • [Book] NEW 生化学2006

    • Author(s)
      新木敏正 他
    • Total Pages
      537
    • Publisher
      廣川書店
    • Data Source
      KAKENHI-PROJECT-17590066
  • [Book] NEW生化学2006

    • Author(s)
      新木敏正 他
    • Total Pages
      537
    • Publisher
      廣川書店
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590066
  • [Book] NEW 生化学2006

    • Author(s)
      新木敏正
    • Total Pages
      537
    • Publisher
      廣川書店
    • Data Source
      KAKENHI-PROJECT-17590066
  • 1.  SUDA Tatsuo (90014034)
    # of Collaborated Projects: 16 results
    # of Collaborated Products: 0 results
  • 2.  TAKAHASHI Naoyuki (90119222)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 0 results
  • 3.  MIYAURA Chisato (20138382)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 4.  UDAGAWA Nobuyuki (70245801)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 5.  KATAGIRI Takenobu (80245802)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 6.  TAKITO Jiro (00197237)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 7.  ABE Etsuko (70119147)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 8.  TAKAMI Masamichi (80307058)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 9.  JIN Cheng He (10205049)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  KAMIJO Ryutaro (70233939)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  MORIMURA Naoko (00349044)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 12.  TANAKA Hirofumi (30146899)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 13.  自見 英治郎 (40276598)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  AKIYAMA Shuichi (70276591)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  MIYAMOTO Youichi (20295132)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  SAKURADA Chikai (30279244)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  山口 朗 (00142430)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KOBAYASHI Makoto (80186767)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  赤池 孝章 (20231798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  NAKAJIMA Takanori (80265404)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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