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SHINKI Toshimasa
新木 敏正
Connect your ORCID iD
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Researcher Number
90138420
Other IDs
External Links
Affiliation (based on the past Project Information)
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2004 – 2006: Nihon Pharmaceutical University, Professor, 薬学部, 教授
1997 – 2003: School of Dentistry, Showa University, Lecturer, 歯学部, 講師
2000: 昭和大, 歯学部, 講師
1986 – 1995: 昭和大学, 歯学部, 講師
1992: Showa Univ., School of Dentistry Associate Professor, 歯学部, 構師
1986: 昭和大学, RIセンター, 講師
Review Section/Research Field
Principal Investigator
Functional basic dentistry
/
Functional basic dentistry
/
Biological pharmacy
Except Principal Investigator
Functional basic dentistry
/
Functional basic dentistry
Keywords
Principal Investigator
活性型ビタミンD / 腎臓 / 副甲状腺ホルモン / ビタミンD / 24-水酸化酵素 / RT-PCR / ODC / 1alpha, 25-dihydroxyvitamin D_3 / ネフロン / ビタミンD受容体
…
More
/ parathyroid hormone / 1alpha-hydroxylase / 24-hydroxylase / kidney / 骨吸収 / トランスジェニック / RANKL / 小腸 / Ca吸収 / ポリアミン / プトレッシン / ポリアミン合成阻害剤 / CaーATPase / ポリアミン酸化酵素 / Intestine / Ca transport / polyamine / putrescine / Ca-ATPase / villus / 脂肪細胞 / 脂質合成 / 骨粗鬆症 / リン脂質 / トリグリセリド / 前脂肪細胞 / デキサメタゾン / 脂質代謝 / 骨髄間質細胞 / ホスファチジルコリン / adipocyte / adipogenesis / osteoporosis / phospholipids / preadipocyte / triacylglycerol / vitamin D derivatives / カルシウム / vitamin D / vitamin D receptor / mRNA / 1α-水酸化酵素 / シトクロムP-450 / シトクロムP450 / 近位尿細管 / proximal convoluted tubules / cytochrome P450 / vitamin D receptors / degenerate-PCR / トランスジェニックラット / 巣状糸球体腎炎 / メガリン / 25-ヒドロキシビタミンD / ビタミンD結合蛋白質 / 単状糸球体腎炎 / 1α,25-dihydroxyvitamin D_3 / 24,25-dihydroxyvitamin D_3 / megalin / transgenic rat / 25-hydroxyvitamin D_3 / vitamin D binding protein / glomerulosclerosis / 歯槽骨 / インターロイキン-1 / 低カルシウム / 歯周病 / 歯根膜 / 破骨細胞 / サイトカイン / 口腔内細菌 / ドライスカル / トランスジェニックマウス / OPG / LPS / Interleukin 1 / transgenic mice / alveolar bone / Bone resorption / Bone mineral density / Long bone / Periodontal disease / 腎性骨症 / 骨量 / ビタミンD代謝 / プロテオミックス / 石灰化 / 副甲状腺 / カルシトニン / 腎炎 / 糖尿病 / Kidney / Renal osteodystrophy / Vitamin D / Parathyroid hormone / Transgenic / Bone mineral / Vitamin D metabolism / Proteomics
…
More
Except Principal Investigator
破骨細胞 / 骨芽細胞 / 活性型ビタミンD / 骨吸収 / 副甲状腺ホルモン / osteoclast / カルシウム / M-CSF / osteoblast / bone resorption / カルシトニン / ODF / RANK / Osteoclast / RANKL / OPG / PTH / 補体第3因子 / カルシウム吸収 / ポリアミン / マクロファ-ジ / 1alpha, 25-Dihydroxyvitamin D_3 / C3 / 1α,25(OH)_2D_3 / 肝臓 / 腎臓 / インターロイキン6 / ビタミンD / 骨 / bone marrow / 骨粗鬆症 / OCIF / Osteoblast / 骨誘導因子 / Calcium / マクロファージ / 細胞融合 / SaOS-2 / 破骨細胞分子因子(ODF) / PTHレセプター / ヒト抹消血単核細胞 / 共存培養 / ヒト抹消血 / ヒト破骨細胞 / 小腸の吸収上皮細胞 / カルシウムポンプ / 骨吸収因子 / 増殖因子 / オステオポンチン / 小腸上皮細胞細胞 / マクロファ-ジコロニ-刺激因子 / Intestine epithelial cells / Osteoblasts / Osteoclasts / Calcium pump / the third component of complement (C3) / Bone resorbing agents / Growth factor / 補体第3成分 / C3レセプター / マウス補体第3成分 / 骨髄間質細胞 / 116kD / ILー1 / complement / C3 receptor / 1alpha,25(OH)_2D_3 / 抗クル病因子 / 小腸 / インターロイキン11 / ビタミンDレセプター / 24,25(OH)_2D_3 / 1alpha, 25(OH)_2D_3 / calcium absorption / gp130 / interleukin 6 / interleukin 11 / 転写調節 / 骨髄ストローマ細胞 / ビタミンD欠乏 / 補体第3因子(C3) / C3遺伝子 / complement 3 / stromal cells / vitamin D / macrophage / bone / エストロゲン / インターロイキン1 / 骨髄造血 / Bリンパ球 / アンドロゲン / プロスタグランジン / estrogen / androgen / interleukin-1 / interleukin-6 / osteoporosis / hemopoiesis / 1α-水酸化酵素 / ステロイドホルモン / parathyroid hormone / 1α,25-dihydroxyvitamin D3 / 1α-hydroxylase / 破骨細胞分化因子 / 破骨細胞形成抑制因子 / 遺伝子欠損マウス / 骨随間質細胞 / マクロファジーコロニー刺激因子 / Bone resorption / TNF / 1α, 25(OH)_2D_3 / 炎症性サイトカイン / TNFα / IL-1 / 細胞内Ca / Inflammatory cytokines / BMP / Osteoporosis / 骨形成 / ホルモン / 成長因子 / 細胞分化 / 筋芽細胞 / 転写調節因子 / 血清 / 受容体 / BONE FORMATION / TRANSCRIPTION FACTOR / HORMONE / GROWTH FACTOR / BONE MORPHOGENETIC PROTEIN / OSTEOBLAST / MYOBLAST / CELL DIFFERENTIATION / 一酸化窒素 / 軟骨細胞 / 滑膜細胞 / 細胞死 / 関節リウマチ / 変形性関節症 / NADPH-oxdiase / ラジカル / 細胞・組織 / シグナル伝達 / ストレス / 生体分子 / 生理活性 / 軟骨 / インターロイキン-1 / スーパーオキサイド / パーオキシナイトライト / ミトコンドリア / ネクローシス / nitric oxide / chondrocytes / synoviocytes / cell death / rheumatoid arthritis / osteoarthritis / NADPH-oxidase / radicals / 分化誘導因子 / 肺胞マクロファージ / 融合 / トリグリセライド / OAF / DIF / LPS / MGBG / 骨吸収活性 / マクロファージの融合 / 多核巨細胞 / Vitamin D / Macrophages / Cell-fusion / 分化誘導因子(DIF) / 活性型ビタミンD_3(1α,25(OH)_2D_3) / マクロファージ融合因子 / マクロファージ融合因子(MFF) / 骨髄細胞 / コロニー形成因子(CSF) / 1alpha,25-dihydroxyvitamin D_3 [1alpha,25(OH)_2D_3 / differentiation-inducing factor (DIF) / macrophage fusion factor (MFF) / osteoblasts / スペルミジン / トランスグルタミナ-ゼ / Macrophage / Cell Fusion / Spermidine / Transglutaminase
Less
Research Projects
(
21
results)
Research Products
(
3
results)
Co-Researchers
(
20
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Evidence base treatment of renal osteodistropy
Principal Investigator
Principal Investigator
SHINKI Toshimasa
Project Period (FY)
2005 – 2006
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Biological pharmacy
Research Institution
Nihon Pharmaceutical University
On the regulation of survival and death of synoviocytes and chondrocytes by nitric oxide
Principal Investigator
MIYAMOTO Yoichi
Project Period (FY)
2004 – 2005
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Functional basic dentistry
Research Institution
Showa University
Mechanisms of bone resorption in alveolar bone of IL-1 transgenic mice
Principal Investigator
Principal Investigator
SHINKI Toshimasa
Project Period (FY)
2003 – 2004
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Functional basic dentistry
Research Institution
Nihon Pharmaceutical University
Showa University
CHARACTERIZATION OF THE BONE FORMING FACTORS IN SERUM
Principal Investigator
KATAGIRI Takenobu
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Functional basic dentistry
Research Institution
SHOWA UNIVERSITY
Role of Vitamin D hydroxylase on Bone Metabolism.
Principal Investigator
Principal Investigator
SHINKI Toshimasa
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Functional basic dentistry
Research Institution
Showa University
The physiological role of osteoclast differentiation factor.
Principal Investigator
UDAGAWA Nobuyuki
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (B).
Research Field
Functional basic dentistry
Research Institution
Showa University
Study on signal transduction in osteoclastogenesis for the development of anti-osteoporosis drugs.
Principal Investigator
TAKAHASHI Naoyuki
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (B).
Research Field
Functional basic dentistry
Research Institution
Showa University
The roles of nuclear transcription factors in calcium homeostasis
Principal Investigator
SUDA Tatsuo
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Functional basic dentistry
Research Institution
Showa University
ヒトPTH受容体遺伝子の導入によるヒト破骨細胞形成系の確立
Principal Investigator
SUDA Tatsuo
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Functional basic dentistry
Research Institution
Showa University
Mechanism of regulation of vitamin D metabolism at molecular level.
Principal Investigator
Principal Investigator
SHINKI Toshimasa,
新木 敏正
Project Period (FY)
1996 – 1997
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Functional basic dentistry
Research Institution
Showa University
Molecular mechanisms of osteoporosis induced by estrogen deficiency.
Principal Investigator
SUDA Tatsuo
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for General Scientific Research (A)
Research Field
Functional basic dentistry
Research Institution
Showa University
Role of vitamin D and parathyroid hormone on vitamin D metabolism in the kidney.
Principal Investigator
Principal Investigator
SHINKI Toshimasa
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Functional basic dentistry
Research Institution
Showa University
Production and biological roles of the third component of complement in bone.
Principal Investigator
MIYAURA Chisato
Project Period (FY)
1993 – 1994
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Functional basic dentistry
Research Institution
Showa University
Molecular aspects of vitamin D metabolism and action
Principal Investigator
SUDA Tatsuo
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for General Scientific Research (A)
Research Field
Functional basic dentistry
Research Institution
Showa University
Cloning of proteins produced by osteoblastic cells in response to 1alpha,25(OH)_2D_3.
Principal Investigator
ABE Etsuko
Project Period (FY)
1991 – 1992
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Functional basic dentistry
Research Institution
Showa University
Role of vitamin D_3 on differentiation of bone marrow-derived stromal cells.
Principal Investigator
Principal Investigator
SHINKI Toshimasa
Project Period (FY)
1991 – 1992
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Functional basic dentistry
Research Institution
Showa University
Basic study on the risk factors of osteoporosis.
Principal Investigator
SUDA Tatsuo
Project Period (FY)
1990 – 1991
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Functional basic dentistry
Research Institution
Showa University
Role of Putrescine in Vitamin D-Dependent Intestinal Cell Differentiation.
Principal Investigator
Principal Investigator
SHINKI Toshimasa
Project Period (FY)
1989 – 1990
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Functional basic dentistry
Research Institution
Showa University
Two step model for the fusion of macrophages induced by 1alpha, 25-dihydroxyvitamin D_3
Principal Investigator
SUDA Tatsuo
Project Period (FY)
1988 – 1989
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Functional basic dentistry
Research Institution
Showa University
Development of new assay systems for examining the relation between osteoblasts and osteoclasts, and identification of new factors controlling bone metabolism
Principal Investigator
SUDA Tatsuo
Project Period (FY)
1986 – 1988
Research Category
Grant-in-Aid for Developmental Scientific Research
Research Field
Functional basic dentistry
Research Institution
Showa University, School of Dentistry
Mechanisms of Fusion of Macrophages Induced by 1 ,25(OH)_2D_3
Principal Investigator
SUDA Tatsuo
Project Period (FY)
1985 – 1987
Research Category
Grant-in-Aid for General Scientific Research (A)
Research Field
Functional basic dentistry
Research Institution
Showa University
All
2006
All
Book
[Book] NEW 生化学
2006
Author(s)
新木敏正 他
Total Pages
537
Publisher
廣川書店
Data Source
KAKENHI-PROJECT-17590066
[Book] NEW生化学
2006
Author(s)
新木敏正 他
Total Pages
537
Publisher
廣川書店
Description
「研究成果報告書概要(和文)」より
Data Source
KAKENHI-PROJECT-17590066
[Book] NEW 生化学
2006
Author(s)
新木敏正
Total Pages
537
Publisher
廣川書店
Data Source
KAKENHI-PROJECT-17590066
# of Projects (Dsc)
# of Projects (Asc)
1.
SUDA Tatsuo
(90014034)
# of Collaborated Projects:
16 results
# of Collaborated Products:
0 results
2.
TAKAHASHI Naoyuki
(90119222)
# of Collaborated Projects:
12 results
# of Collaborated Products:
0 results
3.
MIYAURA Chisato
(20138382)
# of Collaborated Projects:
11 results
# of Collaborated Products:
0 results
4.
UDAGAWA Nobuyuki
(70245801)
# of Collaborated Projects:
9 results
# of Collaborated Products:
0 results
5.
KATAGIRI Takenobu
(80245802)
# of Collaborated Projects:
8 results
# of Collaborated Products:
0 results
6.
TAKITO Jiro
(00197237)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
7.
ABE Etsuko
(70119147)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
8.
TAKAMI Masamichi
(80307058)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
9.
JIN Cheng He
(10205049)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
10.
KAMIJO Ryutaro
(70233939)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
11.
MORIMURA Naoko
(00349044)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
12.
TANAKA Hirofumi
(30146899)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
13.
自見 英治郎
(40276598)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
14.
AKIYAMA Shuichi
(70276591)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
15.
MIYAMOTO Youichi
(20295132)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
16.
SAKURADA Chikai
(30279244)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
17.
山口 朗
(00142430)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
KOBAYASHI Makoto
(80186767)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
赤池 孝章
(20231798)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
NAKAJIMA Takanori
(80265404)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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