KIMURA Hiroto 木村博人

Researcher Number	90142851
External Links
Affiliation (based on the past Project Information) *help	2011 – 2013: 弘前大学, 医学(系)研究科(研究院), 教授 1998 – 2006: 弘前大学, 医学部, 教授 1994 – 1996: Hirosaki University School of Medicine, Oral Surgery, Professor, 医学部, 教授 1993: 弘前大学, 医学部, 助教授 1989: Hirosaki University School of Medicine, Associate Professor, 医学部, 助教授 1988: 弘前大学, 医学部附属病院, 講師 1987: 弘前大学, 医学部・附属病院, 講師
Review Section/Research Field	Principal Investigator Surgical dentistry / Surgical dentistry / 外科・放射線系歯学 / Periodontal dentistry
Keywords	Principal Investigator メカニカルストレス / 炎症性サイトカイン / Osteoprotegerin / sRANKL / MAP kinase / 骨芽細胞 / PCR / MRSA / mechanical stress / jaw cyst … More / 骨吸収 / COX-2 / 口腔癌 / インターロイキン6 / 線維芽細胞 / サイトカイン / Chemiluminescence / Electron Spin Resonance / Polymorphonuclear leukocyte / Oral Cancer / Bleomycin / Anticancer drug / Active oxygen / Free radical / スピンラベル法 / 赤血球膜流動性 / フリーラジカル / 化学発行 / 化学発光法 / 化学発光 / 電子スピン共鳴 / 多形核白血球 / ブレオマイシン / 抗癌剤 / 活性酸素 / フリ-ラジカル / fibroblasts / osteoblasts / vibratory stimulation / BMP-4 / Cbfa-1 / OPG / NO / 再生医学 / 顎骨 / 再生医療 / 振動刺激 / Nitric oxide / Quantitative RT-PCR / Cyclic tensile strain / Mechanical stress / Osteoblast / 機械的刺激 / TAクローニング / 定量PCR法 / Osteoprotegein / 一酸化窒素 / 定量RT-PCR / 周期的細胞伸展 / nitricoxide radical / messenger RNA / immunohistolocal stainin / cyst wall fibroblast / inflanunatory cytokine / bone resortion / 嚢胞壁細胞 / 一酸化窒素ラジカル / メッセンジャーRNA / 免疫組織染色 / 嚢胞壁線維芽細胞 / 顎骨嚢胞 / flow cytometry / active oxygen production / cooperative bactericidal activity / electrolyzed-oxidizing water / antibiotic / neutrophil / infectious disese / フローサイトメトリー / 活性酸素産生能 / 協同的殺菌作用 / 強酸性水 / 抗菌剤 / 好中球 / 難治性感染症 / cytokine / antioxidant enzyme / lipid peroxide / microcirculation / intracystic pressure / bone absorption / シッフ塩基染色法 / レーザードップラー血流計 / 骨吸収因子 / 微小循環障害 / 微小循環 / 抗酸化酵素 / 過酸化脂質 / 嚢胞腔内圧 / 顎嚢胞 / 骨増生法 / 臨床 / 細胞・組織 / 移植・再生医療 / 歯学 / 骨リモデリング / BMP signaling / Wnt signaling / BMP pathway / Wnt pathway / 骨代謝 / メカノセンサー / 骨膜 / 遺伝子解析 / COX-2インヒビター / 転移抑制 / MMP / TNF-α / 抗酸化食品因子 / 歯周疾患 / 緑茶 / カテキン / 歯肉線維芽細胞 / 抗酸化食品 Less

Development of the new bone regeneration method by transplanting jawbone periosteum sheets as a mechanosensor.Principal Investigator
- Principal Investigator
  
  KIMURA Hiroto
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hirosaki University
口腔癌の転移抑制を目指したMMPインヒビター療法開発のための基礎的研究Principal Investigator
- Principal Investigator
  
  木村博人
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Surgical dentistry
- Research Institution
  Hirosaki University
Basic and clinical study aimed for the regenerative medicine of jaw bone by vibratory stimulation systemPrincipal Investigator
- Principal Investigator
  
  KIMURA Hiroto
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hirosaki University
抗酸化食品因子による歯肉線維芽細胞の炎症性サイトカイン産生調節に関する研究Principal Investigator
- Principal Investigator
  
  木村博人
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Periodontal dentistry
- Research Institution
  Hirosaki University
The influence of mechanical stress on the gene expression related to the differentiation and the growth of bone cellPrincipal Investigator
- Principal Investigator
  
  KIMURA Hiroto
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hirosaki University
Molecular biological study on the pathophysiological substances and their interactions concerned with the enlargement of jaw cystPrincipal Investigator
- Principal Investigator
  
  KIMURA Hiroto
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  HIROSAKI UNIVERSITY
Study on the cooperative bactericidal activities between neutrophis and antibiotics, electrolyzed-oxidizing water in serious infection diseasePrincipal Investigator
- Principal Investigator
  
  KIMURA Hiroto
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  HIROSAKI UNIVERSITY
Study on the pathological absorption of maxillary bone induced by mechanical stressPrincipal Investigator
- Principal Investigator
  
  KIMURA Hiroto
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  HIROSAKI UNIVERSITY
The Clinical and Fundamental Study of Free Radicals Produced by Anticancer Drugs and Function of Blood CellsPrincipal Investigator
- Principal Investigator
  
  KIMURA Hiroto
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  外科・放射線系歯学
- Research Institution
  Hirosaki University

All 2014 2012 2007

All Journal Article Presentation

[Journal Article] Periosteum-derived cells respond to mechanical stretch and activate Wnt and BMP signaling pathways2014
- Author(s)
  Ryohei Ito, Tomoh Matsumiya, Takao Kon, Norihiko Narita, Kosei Kubota, Hirotaka Sakaki, Hidemi Yoshida, Tadaatsu Imaizumi, Wataru Kobayashi, Hiroto Kimura
- Journal Title
  
  Biomedical Reserch
  
  Volume: vol.35 Pages: 69-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592979
[Journal Article] Periosteum-derived cells respond to mechanical stretch and activate Wnt andBMP signaling pathways2014
- Author(s)
  Ito R, Matsumiya T, Kon T, Narita N, Kubota K, Sakaki H, Ozaki T, Imaizumi T, Kobayashi W, Kimura H
- Journal Title
  
  Biomed. Res.
  
  Volume: 35 Issue: 1 Pages: 69-79
- DOI
  10.2220/biomedres.35.69
- NAID
  130004903861
- ISSN
  0388-6107, 1880-313X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592979
[Journal Article] Expression of vascular endothelial growth factor by photodynamic therapy with mono-l-aspartyl chlorin e6 (NPe6) in oral squamous cell carcinoma.2007
- Author(s)
  Nakagawa H, Matsumiya T, Sakaki H, Imaizumi T, Kubota K, Kusumi A, Kobayashi W, Kimura H
- Journal Title
  
  Oral Oncology 43(印刷中)
- Data Source
  KAKENHI-PROJECT-17659626
[Presentation] 骨膜由来細胞はメカニカルストレスに応答しWnt signaling pathwayとBMP signaling pathwayが活性化される2014
- Author(s)
  伊藤良平、中川祥、小林恒、木村博人、他
- Organizer
  日本口腔科学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-05-09
- Data Source
  KAKENHI-PROJECT-23592979
[Presentation] 骨膜由来細胞はメカニカルストレスに応答しWnt signaling pathwayと BMP signaling pathwayが活性化される2014
- Author(s)
  伊藤　良平、佐藤　寿、榊　宏剛、久保田　耕世、今　敬生、小林　恒、木村　博人
- Organizer
  日本口腔科学会
- Place of Presentation
  東京都新宿区
- Data Source
  KAKENHI-PROJECT-23592979
[Presentation] Usefulness of two-stage surgery for benign odontogenic tumors showing large cystic, intraosseous lesions in the mandible2012
- Author(s)
  Hiroto KIMURA
- Organizer
  中華民国口腔外科学会
- Place of Presentation
  台中市
- Year and Date
  2012-03-10
- Invited
- Data Source
  KAKENHI-PROJECT-23592979
[Presentation] Usefulness of two-stage surgery for benign odontogenic tumors showing large cystic, intraosseous lesions in the mandible2012
- Author(s)
  Hiroto KIMURA
- Organizer
  第13回中華民国口腔顎面外科学会(招待講演)
- Place of Presentation
  中山医科大学(台中市)
- Data Source
  KAKENHI-PROJECT-23592979

1. WATARU Kobayashi (50234860)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. FUKUI Roh (70241479)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. SAKAKI Hirotaka (90374850)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. KUSUMI Akinori (90332494)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. NAKAGAWA Hiroshi (00529688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. MATSUMIYA Tomoh (30344592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. KUBOTA Kousei (10529689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. ITO Ryohei (20638902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. SATOH Hisashi (90311539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 成田憲司 (50374848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 成田明子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KIMURA Hiroto 木村 博人

Research Projects

Research Products

Co-Researchers

Development of the new bone regeneration method by transplanting jawbone periosteum sheets as a mechanosensor.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

口腔癌の転移抑制を目指したMMPインヒビター療法開発のための基礎的研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basic and clinical study aimed for the regenerative medicine of jaw bone by vibratory stimulation systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗酸化食品因子による歯肉線維芽細胞の炎症性サイトカイン産生調節に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The influence of mechanical stress on the gene expression related to the differentiation and the growth of bone cellPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular biological study on the pathophysiological substances and their interactions concerned with the enlargement of jaw cystPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the cooperative bactericidal activities between neutrophis and antibiotics, electrolyzed-oxidizing water in serious infection diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the pathological absorption of maxillary bone induced by mechanical stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Clinical and Fundamental Study of Free Radicals Produced by Anticancer Drugs and Function of Blood CellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Periosteum-derived cells respond to mechanical stretch and activate Wnt and BMP signaling pathways2014

Author(s)

Journal Title

Data Source

[Journal Article] Periosteum-derived cells respond to mechanical stretch and activate Wnt andBMP signaling pathways2014

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Expression of vascular endothelial growth factor by photodynamic therapy with mono-l-aspartyl chlorin e6 (NPe6) in oral squamous cell carcinoma.2007

Author(s)

Journal Title

Data Source

[Presentation] 骨膜由来細胞はメカニカルストレスに応答しWnt signaling pathwayとBMP signaling pathwayが活性化される2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

KIMURA Hiroto 木村博人