TAKAMATSU Ken 高松研

Researcher Number	90154898
Other IDs
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Affiliation (Current)	2022: 東邦大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help	2015: 東邦大学, 医学部, 教授 2012: 東邦大学, 医学部, 教授 2005 – 2006: 東邦大学, 医学部, 教授 1994 – 2002: 東邦大学, 医学部, 教授 1992 – 1993: 東邦大学, 医学部, 助教授 … More
Review Section/Research Field	Principal Investigator Neurology / Neurochemistry/Neuropharmacology / 分子細胞生物学 / Neurochemistry/Neuropharmacology Except Principal Investigator General physiology / 医学一般 / 広領域 / Psychiatric science / Neurology / Structural biochemistry
Keywords	Principal Investigator ヒポカルシン / Hippocalcin / カルシウム結合蛋白質 / 海馬 / アポトーシス / Calcium-binding protein / cDNA / 細胞死 / 海馬錐体細胞 / 老化 … More Except Principal Investigator 海馬 / 初代培養 / 受精 / 糖鎖 / 学習 / 連合野 / 神経細胞 / fimbria fornix / ガングリオシド / NVP / 生理学 / 発生・分化 / 糖類 / 糖蛋白質 / ニューロン活動 / ボルツマンマシン / 脳内移植 / オリゴデンドログリア / 髄鞘形成 / 周期線 / シバラーミュータントマウス / ミエリン塩基性蛋白 / マウス / 生存 / 2次元電気泳動 / 成長因子 / ラット / GO / NO-GO課題 / GABAニューロン / 非見本合せ / ニューロン / 生存維持 / 神経発育因子 / GABA作働性ニューロン / カルシウム結合蛋白質 / S-モジェリン / ヒポカルシン / リカバリン / カルモジェリン / ニューロカルシン / S-モジュリン / カルモジュリン / リン酸化 / 神経 / calcium-binding proteins / Neuron / S-modulin / Hippocalcin / recoverin / neurocalcin / 精神分裂病 / 異種性 / 5HTR2A遺伝子 / 若年発症精神分裂病 / 遺伝負因 / 環境要因 / hSKCa3遺伝子多型 / CAG repeat多型 / ハロペリドール / 治療反応性 / DRD4遺伝子 / hSKCa3 / CAG repeat / 多型 / レセプター遺伝子多型性 / global assessment scale / schizophrenia / heterogeneity / the 5HTR2A gene / T102C polymorphism / nongenetic causes / juvenile-onset / adult-onset schizophrenia / hSKCa3 gene / デル / 実験的脳腫瘍モデル / CNP(2'3'syclic nucleotide 3'-phospho diesterase) / GFA(Glially fibrillary Acidic Protein) / FIA(Fluoro immuno Assay) / 実験的脳損傷ラット / モノクローン抗体 / CNP / ミエリン / PLP / MBP / 遺伝子診断 / Monoclonal antibody / DNA probe / Fluoroimmuno assay / Immunohistochemistry / Experimental model of brain injury / Experimental model of brain tumor / 糖質 Less

Molecular analysis of a novel fertilization-regulatory protein in the egg-coating envelope.
- Principal Investigator
  
  MIWA Naofumi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Toho University
Molecular mechanisms of the regulation of oligosaccharides within egg-coating envelope during fertilization
- Principal Investigator
  
  MIWA Naofumi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Toho University
Regulation of the survival of mature oligodendrocytes by protein transduction of p38 MAP kinasePrincipal Investigator
- Principal Investigator
  
  TAKAMATSU Ken
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Toho University
Hippocalcin acts as a possible suppressor of neuronal apoptosis via NAIP-caspase and MLK3-JNK cascadesPrincipal Investigator
- Principal Investigator
  
  TAKAMATSU Ken
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Toho University
海馬神経細胞死におけるカルシウム結合蛋白質:ヒポカルシンの関与に関する研究Principal Investigator
- Principal Investigator
  
  高松研
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Toho University
海馬神経細胞死におけるカルシウム結合蛋白質:ヒポカルシンの関与に関する研究Principal Investigator
- Principal Investigator
  
  高松研
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Toho University
The association study of the polymorphism of the receptors and response to antipsychotic drugs in schizophrenia
- Principal Investigator
  
  NAKAMURA Michiko
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Toho Unversity
Biochemical and physiological assessment of neural visinin-like calcium-binding protein 3 in rodent cerebellum.Principal Investigator
- Principal Investigator
  
  TAKAMATSU Ken
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Toho University
海馬神経細胞死におけるカルシウム結合蛋白質:ヒポカルシンの関与に関する研究Principal Investigator
- Principal Investigator
  
  高松研
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Toho University
Molecular cloning and chromosomal localization of the genes encoding P23k neuron-specific calcium-binding protein family.Principal Investigator
- Principal Investigator
  
  TAKAMATSU Ken
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Toho University
Structure and Function of Novel Neuron-specific Calcium-binding Proteins
- Principal Investigator
  
  KAWAMURA Satoru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  広領域
- Research Institution
  Graduate School of Science, Osaka University
Molecular Cloning and Chromosomal Localization of Human Hippocalcin Gene.Principal Investigator
- Principal Investigator
  
  TAKAMATSU Ken
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Toho University
Studies on calcium-sensitive regulators of signal transduction in central nervous system.Principal Investigator
- Principal Investigator
  
  TAKAMATSU Ken
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  分子細胞生物学
- Research Institution
  Toho University
神経回路網の形成に関与するラット海馬由来神経発育因子の神経化学的研究
- Principal Investigator
  
  高坂新一
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Keio University
高次脳過程の可塑性の研究
- Principal Investigator
  
  久保田競
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyoto University
先天性代謝病モデル動物による脳内移植の治療的研究
- Principal Investigator
  
  KOHSAKA Shin-ichi
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Keio University
神経回路網の形成に関与するラット海馬由来成長因子の神経化学的研究
- Principal Investigator
  
  高坂新一
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Keio University
神経の再生に於けるラット海馬由来因子の機能的意義に関する研究
- Principal Investigator
  
  高坂新一
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医学一般
- Research Institution
  Keio University
高次脳過程の可塑性の研究
- Principal Investigator
  
  久保田競
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyoto University
Development Diagnostic Method of Brain Disorders Using DNZ Probe and Monoclonal Antribody.
- Principal Investigator
  
  TSUKADA Yasuzo
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Neurology
- Research Institution
  KEIO UNIVERSITY SCHOOL OF MEDICINE

All 2015 2014 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Fertilization competence of the egg-coating envelope is regulated by direct interaction of dicalcin and gp41, the Xenopus laevis ZP32015
- Author(s)
  Miwa N, Ogawa M, Hanaue M, Takamatsu K
- Journal Title
  
  Sci Rep
  
  Volume: 5 Pages: 12672-12672
- DOI
  10.1038/srep12672
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25440035
[Journal Article] Immunohistochemical Characterization of S100A6 in the Murine Ovary2012
- Author(s)
  Hanaue M, Miwa N, Takamatsu K
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 45 Issue: 1 Pages: 9-14
- DOI
  10.1267/ahc.11035
- NAID
  130001258483
- ISSN
  0044-5991, 1347-5800
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590213
[Journal Article] Characterization of S100A11, a suppressive factor of fertilization, in the mouse female reproductive tract2011
- Author(s)
  Hanaue M, Miwa N, Uebi T, Fukuda Y, Katagiri Y, Takamatsu K
- Journal Title
  
  Mol Reprod Dev
  
  Volume: 78 Pages: 91-103
- DOI
  10.1002/mrd.21273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590213
[Journal Article] Dicalcin inhibits fertilization through its binding to a glycoprotein in the egg envelope in Xenopus laevis2010
- Author(s)
  Miwa N, Ogawa M, Shinmyo Y, Hiraoka Y, Takamatsu K, Kawamura S
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 15627-36
- DOI
  10.1074/jbc.m109.079483
- NAID
  40018739339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590213
[Presentation] Structural regulation of the extracellular egg-coating envelope by the interaction between Xenopus gp41 and dicalcin2015
- Author(s)
  三輪尚史, 高松研
- Organizer
  第88回日本生化学大会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25440035
[Presentation] Reversible changes in the orientation pattern of ZP filaments in the extracellular coat of Xenopus egg by dicalcin2015
- Author(s)
  三輪尚史, 花上まゆ, 高松研
- Organizer
  第47回日本結合組織学会学術大会
- Place of Presentation
  コクヨホール（東京都港区）
- Year and Date
  2015-05-16
- Data Source
  KAKENHI-PROJECT-25440035
[Presentation] Structural pasticity of the mature egg-coating envelope accompanied by the extrinsic control of fertilization success in Xenpus laevis2015
- Author(s)
  三輪尚史, 花上まゆ, 高松研
- Organizer
  第48回日本発生生物学会
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2015-06-03
- Data Source
  KAKENHI-PROJECT-25440035
[Presentation] Identification of the interactive region on gp41, Xenopus orthologue of ZP3, for its target Xenopus dicalcin.2014
- Author(s)
 Miwa, N., Hanaue, M., Takamatsu, K.
- Organizer
 47th Annual Meeting of Society for the Study of Reproduction
- Place of Presentation
 アメリカ、ミシガン州、グランドラピッド市
- Year and Date
 2014-07-21
- Data Source
 KAKENHI-PROJECT-25440035
[Presentation] Identification of dicalcin-binding region on gp41, a Xenopus orthologue of ZP32014
- Author(s)
  三輪尚史、花上まゆ、高松研
- Organizer
  第４７回日本発生生物学会大会
- Place of Presentation
  愛知県名古屋市、ウインクあいち
- Year and Date
  2014-05-29
- Data Source
  KAKENHI-PROJECT-25440035
[Presentation] Characterization of the mouse counterpart of frog dicalcin in the female reproductive tissue2012
- Author(s)
  三輪尚史、花上まゆ、高松研
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本市総合体育館(長野県)
- Year and Date
  2012-03-31
- Data Source
  KAKENHI-PROJECT-22590213
[Presentation] Characterization of Mouse Dicalcin in the Female Reproductive Tissue2012
- Author(s)
  三輪尚史、花上まゆ、高松研
- Organizer
  第45回日本発生生物学会大会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-22590213
[Presentation] 受精阻害因子ダイカルシンによる卵保護膜内糖鎖分布制御機構の解析2011
- Author(s)
  三輪尚史、花上まゆ、高松研
- Organizer
  第43回日本結合組織学会学術大会
- Place of Presentation
  別府ビーコンプラザ(大分県)
- Year and Date
  2011-06-10
- Data Source
  KAKENHI-PROJECT-22590213
[Presentation] Characterization of Mouse Dicalcin, a Potential Suppressive Factor of Fertilization, in the Mouse Female Reproductive Tract2011
- Author(s)
  Miwa N, Hanaue M, Takamatsu K
- Organizer
  45th Annual Meeting of Society for the Study of Reproduction
- Place of Presentation
  Portland(アメリカ)
- Year and Date
  2011-07-31
- Data Source
  KAKENHI-PROJECT-22590213
[Presentation] Identification of the counterpart of Xenopus dicalcin in the mouse female reproductive tract2011
- Author(s)
  三輪尚史、花上まゆ、高松研
- Organizer
  第88回日本生理学会大会
- Place of Presentation
  JPS 誌上開催
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22590213
[Presentation] Identification of binding regions on Xenopus dicalcin for its target glycoprotein in the egg-coating envelope2010
- Author(s)
  三輪尚史、花上まゆ、高松研
- Place of Presentation
  タワーホール船堀(東京都)
- Year and Date
  2010-03-27
- Data Source
  KAKENHI-PROJECT-22590213
[Presentation] Molecular analysis of Xenopus dicalcin during fertilization2010
- Author(s)
  三輪尚史、小川元之、平岡芳樹、高松研、河村悟
- Organizer
  第43回日本発生生物学会
- Place of Presentation
  京都国際会館(京都府)
- Year and Date
  2010-06-22
- Data Source
  KAKENHI-PROJECT-22590213
[Presentation] Xenopus dicalcin, an intrinsic and suppressive mediator of sperm-egg interaction and subsequent fertilization2010
- Author(s)
  Miwa N, Ogawa M, Hiraoka Y, Takamatsu K, Kawamura S.
- Organizer
  43rd annual meeting of Society for the study of Reproduction
- Place of Presentation
  Milwaukee(アメリカ)
- Year and Date
  2010-07-31
- Data Source
  KAKENHI-PROJECT-22590213
[Presentation] Inhibitory action of Xenopus dicalcin on sperm-egg interaction during fertilization2010
- Author(s)
  Miwa N, Ogawa M, Hiraoka Y, Takamatsu K, Kawamura S
- Organizer
  69th annual meeting of Society for Developmental Biology
- Place of Presentation
  New Mexico(アメリカ)
- Year and Date
  2010-07-31
- Data Source
  KAKENHI-PROJECT-22590213
[Presentation] Molecular analysis of inhibitory effects of Xenopus dicalcin on the fertilization process2010
- Author(s)
  三輪尚史、小川元之、平岡芳樹、高松研、河村悟
- Organizer
  第87回日本生理学会大会
- Place of Presentation
  盛岡市民文化ホール(岩手県)
- Year and Date
  2010-05-19
- Data Source
  KAKENHI-PROJECT-22590213
[Presentation] Molecular mechanism for the interaction between Xenopus dicalcin and gp41, a Xenopus orthologue of ZP3
- Author(s)
 Miwa, N., Hanaue M., Takamatsu K.
- Organizer
 46th Annual Meeting of Society for the Study of Reproduction
- Place of Presentation
 カナダ、モントリオール
- Data Source
 KAKENHI-PROJECT-25440035
[Presentation] Identification of interactive regions on Xenopus dicalcin for its target glycoprotein, gp41
- Author(s)
 三輪尚史、花上まゆ、高松研
- Organizer
 第４６回日本発生生物学会大会
- Place of Presentation
 島根県松江市、くにびきメッセ
- Data Source
 KAKENHI-PROJECT-25440035
[Presentation] Identification of the interactive regions between dicalcin and gp41; development of compounds that control the fertilization rate in frogs
- Author(s)
  三輪尚史、花上まゆ、高松研
- Organizer
  第９１回日本生理学会大会
- Place of Presentation
  鹿児島県鹿児島市、鹿児島大学郡元キャンパス
- Data Source
  KAKENHI-PROJECT-25440035
[Presentation] Amino acid regions responsible for the interaction between dicalcin and gp41, a frog ZP protein
- Author(s)
  三輪尚史、花上まゆ、高松研
- Organizer
  第３２回日本糖質学会年会
- Place of Presentation
  大阪府大阪市、大阪国際交流センター
- Data Source
  KAKENHI-PROJECT-25440035

1. KOHSAKA Shin-ichi (50112686)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. FUJISHIRO Masatoshi (40173421)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. 増尾好則 (60301553)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. 吉田一成 (70166940)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 井上洋 (70138030)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. MIWA Naofumi (40255427)

# of Collaborated Projects: 2 results

# of Collaborated Products: 23 results
7. 久保田競 (30027479)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 二木宏明 (10073074)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 酒田英夫 (10073066)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 平野俊二 (50046869)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 甘利俊一 (80010726)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. KAWAMURA Satoru (80138122)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HIDAKA Hiroyoshi (80100171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MIKI Naomasa (40094445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TOKUNAGA Fumio (80025452)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KUNO Takayoshi (50144564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NAKAMURA Michiko (50180401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. SUGAWARA Michiya (30226427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. SUZUKI Jiro (10090408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HAMANOUE Makoto (00312025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. OSAWA Ikrou (30343586)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. TSUKADA Yasuzo (00050956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. TOYA Shigeo (40051205)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. MIKOSHIBA Katsuhiko (30051840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 長池一博

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAMATSU Ken 高松 研

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Regulation of the survival of mature oligodendrocytes by protein transduction of p38 MAP kinasePrincipal Investigator

Principal Investigator

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Hippocalcin acts as a possible suppressor of neuronal apoptosis via NAIP-caspase and MLK3-JNK cascadesPrincipal Investigator

Principal Investigator

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Research Institution

海馬神経細胞死におけるカルシウム結合蛋白質:ヒポカルシンの関与に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

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海馬神経細胞死におけるカルシウム結合蛋白質:ヒポカルシンの関与に関する研究Principal Investigator

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Biochemical and physiological assessment of neural visinin-like calcium-binding protein 3 in rodent cerebellum.Principal Investigator

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Research Field

Research Institution

海馬神経細胞死におけるカルシウム結合蛋白質:ヒポカルシンの関与に関する研究Principal Investigator

Principal Investigator

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Molecular cloning and chromosomal localization of the genes encoding P23k neuron-specific calcium-binding protein family.Principal Investigator

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Principal Investigator

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Molecular Cloning and Chromosomal Localization of Human Hippocalcin Gene.Principal Investigator

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Studies on calcium-sensitive regulators of signal transduction in central nervous system.Principal Investigator

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TAKAMATSU Ken 高松研