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Heike Toshio  平家 俊男

ORCIDConnect your ORCID iD *help
… Alternative Names

HEIKE Toshio  平家 俊男

平家 俊男  ヘイケ トシオ

平家 敏男  ヘイケ トシオ

平家 俊夫

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Researcher Number 90190173
Other IDs
External Links
Affiliation (Current) 2025: 京都大学, 医学研究科, 名誉教授
Affiliation (based on the past Project Information) *help 2017 – 2018: 京都大学, 医学研究科, 名誉教授
2016: 京都大学, 医学研究科, 教授
2016: 京都大学, 大学院医学研究科発達小児科学, 教授
2015: 京都大学, 大学院医学研究科, 教授
2011 – 2015: 京都大学, 医学(系)研究科(研究院), 教授 … More
2014: 京都大学, 医学研究科, 教授
2014: 京都大学, 大学院医学研究科
2012: 京都大学, 大学院・医学研究科, 教授
2012: 京都大学, 大学院医学研究科, 教授
2009 – 2012: Kyoto University, 医学研究科, 教授
2011: 京都大学, 医学研究科, 講師
2010: Kyoto University, 大学院・医学研究科, 教授
2008: 京都大学, 大学院・医学研究科小児科, 准教授
2007 – 2008: Kyoto University, Graduate School of Medicine, Associate Professor
2007: Kyoto University, 京都大学・医学研究科, 准教授
2007: 京都大学, 医学研究科, 准教
2001 – 2006: Graduate School of Medicine KYOTO UNIVERSITY Associated Professor, 医学研究科, 助教授
1999: 東京大学, 医科学研究所, 客員助教授
1999: 東京大学, 医科学研究所, 客員教授
1996 – 1997: 東京大学, 医科学研究所, 客員助教授
1987 – 1988: 京都大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Pediatrics / Biological Sciences / Pediatrics / Neuroscience in general
Except Principal Investigator
Pediatrics / Pediatrics / Ophthalmology / Functional biochemistry / Respiratory organ internal medicine / Circulatory organs internal medicine / Embryonic/Neonatal medicine / Circulatory organs internal medicine / Cell biology
Keywords
Principal Investigator
ES細胞 / 骨格筋 / iPS細胞 / 造血幹細胞 / satellite cell / c-kit / GFP / satellite細胞 / 筋ジストロフィー症 / インフラマソーム … More / 自己炎症性疾患 / 再生医学 / 再生医療 / 組織幹細胞 / 再生 / 骨格筋幹細胞 / Lin / Sca-1 / skeletal muscle / hematopoietic stem cell / 筋ジストロフィー / 自己炎症疾患 / 軟骨細胞 / CAPS / モザイシズム / 間葉系幹細胞 / sphere / 多能性 / 可塑性 / 骨髄 / 移植 / SCID / NOD / 神経幹細胞 / 病態解析 / 低分子蛍光センサー / 蛋白質会合蛍光センサー / regeneration / muscular dystrophy / skeletal muscle stem cell / ES cell / embryoid body / 遺伝子治療 / muscular stem cell / 機能 / 多能性幹細胞 / irradiation / plasticity / ラミニン / single fiber culture / 幹細胞 / 骨髄細胞 / c-kit遺伝子 / 放射線照射 / 造血幹細胞移植 / 単球、マクロファージ / 単球・マクロファージ / 病態解明 / 細胞障害性T細胞 / NK細胞 / 血球貪食症候群 / FHL / 創薬基盤開発 / 機能解析 / 免疫調節異常症 / 血球貪食性リンパ組織球症 / iPS 細胞 / mevalonate kinase / 自然免疫 / 次世代シークエンサー / インフラマゾーム / NLRP3 / 高IgD症候群 / 繊維芽細胞 / 造血・免疫細胞 / 線維芽細胞 / 造血細胞 / sphere法 / MAPC / 心筋細胞 / 循環器 / 中枢神経障害 / ムコ多糖類症 / 難治性疾患 / 奇形種 / 液性因子 / ムコ多糖症 / 分化能 / ヒト臍帯血細胞 / γcnull / 免疫不全マウス / 肝障害 / アルブミン / 臍帯血 / γ_c^<null>マウス / 肝細胞 / 脾臓 / 胸腺 / T細胞 / 免疫機構再構築 / γ_c^<null> / neurosphere / グリア / ニューロン / モノクローナル抗体 … More
Except Principal Investigator
iPS細胞 / 造血幹細胞 / ES細胞 / 再生医療 / 再生医学 / gp130 / NLRP3 / キメラ受容体 / STAT3 / 自己複製機構 / LIF / 自己炎症性疾患 / CAPS / 自然免疫 / 全エクソーム解析 / 炎症 / 疾患特異的iPS細胞 / 迅速診断 / 迅速診断法 / 原発性免疫不全症 / 骨髄不全 / 体細胞モザイク / 幹細胞 / p300 / 遺伝子クローニング / ヒト / 移植 / 分化 / 自己複製 / トランスジェニックマウス / Leukemia Inhibitory Factor(LIF) / 機能病態解析 / 病態解析 / 迅速スクリーニング / バイオマーカー検索 / 細胞ライブラリー / 機能解析系の確立 / 機能解析 / 分子病態解析 / 血球貪食性リンパ組織球症 / 眼難治疾患 / スクリーニング / 創薬 / 眼疾患 / 神経保護 / MAFB / 遺伝子改変マウス / 遺伝子異常 / 遺伝性炎症性疾患 / NLRC4 / 遺伝子探索 / IFIH1 / deep intron変異 / PCYT1A / 炎症性疾患 / Aicardi-Goutieres症候群 / メバロン酸キナーゼ欠損症 / FLNA異常症 / NLRC4異常症 / Histamine / Asthma / Interferon / ヒスタミン遊離 / 2′,5′オリゴアデニレート / IgE受容体 / ヒスタミン / 気管支喘息 / インターフェロン / molecular cloning / transplantation / culture / regenarated medicine / mouse / stromal cell line / hematopoietic stem cells / embryonic stem cells / AGM領域 / Flk1 / 中胚葉細胞 / 培養 / マウス / ストローマ細胞 / transgenic mice / self-renewal mechanism / chimeric cytokine receptor / Embryonic stem cell / Cytokine / サイトカイン / 好中球 / 好中球減少 / 疾患モデル / 細胞死 / 次世代シークエンサー / 単細胞解析 / 軟骨分化 / 遺伝子診断 / 自己炎症 / ELISA / インフラマソーム / SOX9 / FilaminA / FilaminA異常症 / 不明熱 / 軟骨 / メンデル遺伝疾患 / 自己炎症性症候群 / ヒト誘導多能性幹細胞 / ヒト胚性幹細胞 / 骨格筋分化 / 細胞治療 / サテライト細胞 / 筋ジストロフィー / 筋疾患 / 骨格筋 / Ips細胞 / 家族性血球貪食症候群 / 家族性血球貪食性リンパ組織球症 / Birt-Hogg-Dube症候群 / 分化誘導 / I型肺胞上皮細胞 / 疾患特異的iPS / リンパ脈管筋腫症 / 若年性肺気腫 / 特発性間質性肺炎 / 肺胞上皮細胞 / 疾患特異iPS / 嚢胞性線維症 / Hermansky-Pudlak 症候群 / 3次元培養 / carboxypeptidase M / surfactant protein C / II型肺胞上皮細胞 / 白血病 / 発生・分化 / CINCA症候群 / 膠原病 / アレルギー / 小児免疫 / 循環器・高血圧 / トランスレーショナルリサーチ / 肥大 / 転写因子 / 心筋細胞 / 心不全 / NOGマウス / lbotenate / Ibotenate / 脳室周囲白質軟化症 / ES cells / differentiation / regeneration / cardiac myocyte / acetylation / transcription / GATA-4 / ex vivo増幅 / 可塑性 / 自己複製因子 / ノックアウトマウス / hemangioblast / 発生 / 体性幹細胞 / 再生 / 倫理 / 組織幹細胞 / HES / 胚性幹細胞 / Stem Cell Factor(SCF) / コロニー形成 / シグナル伝達分子 / 胚幹細胞(ES細胞) Less
  • Research Projects

    (36 results)
  • Research Products

    (181 results)
  • Co-Researchers

    (61 People)
  •  Elucidating the mechanism of NLRP3 inflammasome activation using fluorescence and light emission protein-interaction sensorsPrincipal Investigator

    • Principal Investigator
      Heike Toshio
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Exploration of the causative genes and elucidation of the pathophysiology on immune dysregulatory diseases with intractable inflammation

    • Principal Investigator
      Ryuta Nishikomori
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Development of neuroprotective drugs

    • Principal Investigator
      Ikeda Hanako
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Ophthalmology
    • Research Institution
      Kyoto University
  •  Establishing a platform for molecular analysis and drug innovation of auto-inflammatory disordersPrincipal Investigator

    • Principal Investigator
      Heike Toshio
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Establishing an innovative platform for the analysis of hemophagocytic lymphohistiocytosis

    • Principal Investigator
      Yasumi Takahiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Establishing the research basis for innovative medical care of familial hemophagocytic lymphohistiocytosis.Principal Investigator

    • Principal Investigator
      HEIKE Toshio
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Exploration of the responsible gene and the pathophysiology for unidentified fever syndromes by whole genome analysis and cell-based engineering

    • Principal Investigator
      NISHIKOMORI Ryuta
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Establishment of a novel disease model using disease specific iPS cells of congenital neutropenia

    • Principal Investigator
      WATANABE Kenichiro
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Analysis and development of medical treatment for autoinflammatory diseasesPrincipal Investigator

    • Principal Investigator
      HEIKE TOSHIO
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Development of the next-generation medical treatment for muscularDystrophyPrincipal Investigator

    • Principal Investigator
      HEIKE Toshio
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Isolation of myogenic stem/progenitors fromhuman ES/iPS cells.

    • Principal Investigator
      AWAYA Tomonari
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Researches using iPS cells on intractable respiratory diseases to elucidate their pathogenesis and develop novel therapy.

    • Principal Investigator
      MISHIMA MICHIAKI
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kyoto University
  •  Establishing rapid diagnostic method and unraveling the pathogenesis offamilial hemophagocytic lymphohistiocytosis

    • Principal Investigator
      YASUMI Takahiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Development of CINCA syndrome therapy based upon the pathophysiology of CINCA syndrome elucidated by cytoengineering.

    • Principal Investigator
      NISHIKOMORI Ryuta
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Investigation of pathogenesis and novel therapy for Shwachman-Diamond syndrome using iPS cells.

    • Principal Investigator
      WATANABE Kenichiro
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Generation of hematopoietic cells and immune cells from iPS cellsPrincipal Investigator

    • Principal Investigator
      HEIKE Toshio
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Analysis of proliferation and differentiation of human embryonic stem cells and research for clinical application

    • Principal Investigator
      NAKAHATA Tatsutoshi
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Elucidating signaling mechanisms of myocardial cell hypertrophy and differentiation and their translational research

    • Principal Investigator
      HASEGAWA Koji
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Department of Clinical Research, National Hospital Organization Kyoto Medical Center
  •  体細胞より作成された胚性幹(ES)様細胞を用いた造血細胞作成の基盤技術開発Principal Investigator

    • Principal Investigator
      平家 俊男
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Establishment of therapeutic strategy for degenerative muscular disease by embryonic stem milsPrincipal Investigator

    • Principal Investigator
      HEIKE Toshio
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  骨髄由来多能性組織幹細胞の作成と同幹細胞を用いた心不全疾患治療の基盤技術の開発Principal Investigator

    • Principal Investigator
      平家 俊男
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  脳室周囲白質軟化症モデルマウスに対するシュワン細胞移植の検討

    • Principal Investigator
      河井 昌彦
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      Kyoto University
  •  Establishment of therapeutic strategy for degenerative muscular disease by mouse or human somatic stem cellsPrincipal Investigator

    • Principal Investigator
      HEIKE Toshio
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  免疫不全マウスへのGFP標識臍帯血細胞移植による多分化能、クローナリティー解析Principal Investigator

    • Principal Investigator
      平家 俊男
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  ES細胞由来神経幹細胞を用いたムコ多糖類症合併中枢神経障害に向けた治療技術の開発Principal Investigator

    • Principal Investigator
      平家 俊男
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  p300発現ES細胞株の樹立とそれを用いた不全心への心筋細胞移植

    • Principal Investigator
      HASEGAWA Koji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kyoto University
  •  ESTABLISHMENT OF FUNDAMENTAL STRATEGIES FOR SKELETAL MUSCLE TISSUE REGENERAIZON USING HEMATOPOIETIC CELLS FOR MUSCULAR DYSTROPHY DISEASEPrincipal Investigator

    • Principal Investigator
      HEIKE Toshio
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      KYOTO UNIVERSITY
  •  免疫不全マウスを用いたヒト造血幹細胞に由来する免疫細胞再構築と感染制御機構の解析Principal Investigator

    • Principal Investigator
      平家 俊男
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  ES細胞、組織幹細胞の増殖・分化機構の解明とその臨床応用に関する研究

    • Principal Investigator
      NAKAHATA Tatsutoshi
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Creative Scientific Research
    • Research Institution
      Kyoto University
  •  study on the induction mechanism of hematopoietic stem cells from embryonic stem cell

    • Principal Investigator
      NAKAHARA Tatsutoshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pediatrics
    • Research Institution
      KYOTO UNIVERSITY
  •  胚幹細胞株を用いた血液幹細胞の自己複製能及び分化制御機構の分子生物学的解析

    • Principal Investigator
      横田 崇
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cell biology
    • Research Institution
      The University of Tokyo
  •  神経幹細胞を特異的に認識するモノクローナル抗体の作製Principal Investigator

    • Principal Investigator
      西中村 隆一, 平家 俊男
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neuroscience in general
    • Research Institution
      The University of Tokyo
  •  ANALYSIS FOR MECHANISM OF SELF-RENEWAL SIGNAL TRANSDUCTION IN EMBRYONIC STEM CELLS

    • Principal Investigator
      YOKOTA Takashi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokyo
  •  サイトカインレセプターシグナル制御による造血幹細胞の自己複製能及び分化能の解析

    • Principal Investigator
      横田 崇
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  サイトカインレセプターシグナル制御による造血幹細胞の自己複製能及び分化能の解析

    • Principal Investigator
      YOKOTA Takashi
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Biochemical significance of interferon as a worsening factor of bronchial asthma

    • Principal Investigator
      MIKAWA Haruki
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2002 Other

All Journal Article Presentation Book Patent

  • [Book] 自己炎症性疾患・自然免疫不全症とその近縁疾患2012

    • Author(s)
      平家俊男, 他
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-23249056
  • [Book] 診断と治療社自己炎症性疾患・自然免疫不全症とその周辺疾患2012

    • Author(s)
      近藤直実・平家俊男
    • Total Pages
      280
    • Data Source
      KAKENHI-PROJECT-22591159
  • [Journal Article] Fever of unknown origin with rashes in early infancy is indicative of adenosine deaminase type 2 deficiency2017

    • Author(s)
      Nihira H、Nakagawa K、Izawa K、Kawai T、Yasumi T、Nishikomori R、Nambu M、Miyagawa-Hayashino A、Nomura T、Kabashima K、Ito M、Iwaki-Egawa S、Sasahara Y、Nakayama M、Heike T
    • Journal Title

      Scandinavian Journal of Rheumatology

      Volume: 47 Issue: 2 Pages: 170-172

    • DOI

      10.1080/03009742.2017.1324912

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19640, KAKENHI-PROJECT-15H04876
  • [Journal Article] Accurate clinical genetic testing for autoinflammatory diseases using the next-generation sequencing platform MiSeq2017

    • Author(s)
      Nakayama Manabu、Oda Hirotsugu、Nakagawa Kenji、Yasumi Takahiro、Kawai Tomoki、Izawa Kazushi、Nishikomori Ryuta、Heike Toshio、Ohara Osamu
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 9 Pages: 146-152

    • DOI

      10.1016/j.bbrep.2016.12.002

    • NAID

      120006355733

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K19640, KAKENHI-PROJECT-15H04876
  • [Journal Article] Live-attenuated vaccines in a cryopyrin-associated periodic syndrome patient receiving canakinumab treatment during infancy2017

    • Author(s)
      Watanabe, M. Nishikomori, R. Fujimaki, Y. Heike, T. Ohara, A. Saji, T.
    • Journal Title

      Clin Case Rep

      Volume: 11 Issue: 11 Pages: 1750-1755

    • DOI

      10.1002/ccr3.1149

    • NAID

      120006533285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04876
  • [Journal Article] Identification of a High-Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell-Based Phenotype Dissection.2017

    • Author(s)
      Kawasaki Y, Oda H, Ito J, Niwa A, Tanaka T, Hijikata A, Seki R, Nagahashi A, Osawa M, Asaka I, Watanabe A, Nishimata S, Shirai T, Kawashima H, Ohara O, Nakahata T, Nishikomori R, Heike T, Saito MK.
    • Journal Title

      Arthritis Rheumatol.

      Volume: 69 Issue: 2 Pages: 447-459

    • DOI

      10.1002/art.39960

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26253062, KAKENHI-PROJECT-15H04876, KAKENHI-PROJECT-15K00411, KAKENHI-PROJECT-15K06921, KAKENHI-PROJECT-15K21487
  • [Journal Article] A CD57+ CTL degranulation assay effectively identifies familial hemophagocytic lymphohistiocytosis type 3 patients2017

    • Author(s)
      Masayuki Hori, Takahiro Yasumi, Saeko Shimodera, Hirofumi Shibata, Eitaro Hiejima, Hirotsugu Oda, Kazushi Izawa, Tomoki Kawai, Masataka Ishimura, Naoko Nakano, Ryutaro Shirakawa, Ryuta Nishikomori, Hidetoshi Takada, Satoshi Morita, Hisanori Horiuchi, Osamu Ohara, Eiichi Ishii, and Toshio Heike
    • Journal Title

      Journal of Clinical Immunology

      Volume: 37 Issue: 1 Pages: 92-99

    • DOI

      10.1007/s10875-016-0357-3

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26461582, KAKENHI-PROJECT-15K19623, KAKENHI-PROJECT-16K08574, KAKENHI-PROJECT-15H04876, KAKENHI-PROJECT-15K09655
  • [Journal Article] Exon skipping causes atypical phenotypes associated with a loss-of-function mutation in FLNA by restoring its protein function2016

    • Author(s)
      Oda H., Sato T., Kunishima S., Nakagawa K., Izawa K., Hiejima E., Kawai T., Yasui T., Doi H., Katamura K., Numabe H., Okamoto S., Nakase H., Hijikata A., Ohara O., Suzuki H., Morisaki H., Morisaki T., Nunoi H., Hattori S., Nishikomori R., Heike T.
    • Journal Title

      Eur J Hum Genet

      Volume: 24 Issue: 3 Pages: 408-414

    • DOI

      10.1038/ejhg.2015.119

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04876, KAKENHI-PROJECT-25461143, KAKENHI-PROJECT-26860796
  • [Journal Article] Genetic and clinical features of cryopyrin-associated periodic syndromes in Turkish children2016

    • Author(s)
      Eroglu, F. K. Kasapcopur, O. Besbas, N. Ozaltin, F. Bilginer, Y. Barut, K. Mensa-Vilaro, A. Nakagawa, K. Heike, T. Nishikomori, R. Arostegui, J. Ozen, S.
    • Journal Title

      Clin Exp Rheumatol

      Volume: 34

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04876
  • [Journal Article] Brief Report: Late-Onset Cryopyrin-Associated Periodic Syndrome Due to Myeloid-Restricted Somatic NLRP3 Mosaicism2016

    • Author(s)
      Mensa-Vilaro, A. Teresa Bosque, M. Magri, G. Honda, Y. Martinez-Banaclocha, H. Casorran-Berges, M. Sintes, J. Gonzalez-Roca, E. Ruiz-Ortiz, E. Heike, T. Martinez-Garcia, J. J. Baroja-Mazo, A. Cerutti, A. Nishikomori, R. Yague, J. Pelegrin, P. Delgado-Beltran, C. Arostegui, J. I.
    • Journal Title

      Arthritis Rheumatol

      Volume: 68 Issue: 12 Pages: 3035-3041

    • DOI

      10.1002/art.39770

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04876
  • [Journal Article] Febrile attacks triggered by milk allergy in an infant with mevalonate kinase deficiency2016

    • Author(s)
      Nakashimai, H. Miyake, F. Ohki, S. Hattori, S. Matsubayashi, T. Izawa, K. Nishikomori, R. Heike, T. Honda, Y. Shigematsu, Y.
    • Journal Title

      Rheumatol Int

      Volume: 36 Issue: 10 Pages: 1477-1478

    • DOI

      10.1007/s00296-016-3522-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04876
  • [Journal Article] Laboratory parameters identify familial haemophagocytic lymphohistiocytosis from other forms of paediatric haemophagocytosis2015

    • Author(s)
      Yasumi T, Hori M, Hiejima E, Shibata H, Izawa K, Oda H, Yoshioka K, Nakagawa K, Kawai T, Nishikomori R, Ohara O, Heike T
    • Journal Title

      British Journal of Haematology

      Volume: 170 Issue: 4 Pages: 532-538

    • DOI

      10.1111/bjh.13461

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26461582, KAKENHI-PROJECT-25670475
  • [Journal Article] Enhanced chondrogenesis of induced pluripotent stem cells from patients with neonatal-onset multisystem inflammatory disease occurs via the caspase 1-independent cAMP/protein kinase A/CREB pathway2015

    • Author(s)
      Yokoyama, K. Ikeya, M. Umeda, K. Oda, H. Nodomi, S. Nasu, A. Matsumoto, Y. Izawa, K. Horigome, K. Kusaka, T. Tanaka, T. Saito, M. K. Yasumi, T. Nishikomori, R. Ohara, O. Nakayama, N. Nakahata, T. Heike, T. Toguchida, J.
    • Journal Title

      Arthritis Rheumatol

      Volume: 67 Issue: 1 Pages: 302-314

    • DOI

      10.1002/art.38912

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-24390353, KAKENHI-PROJECT-24591507, KAKENHI-PROJECT-25461591, KAKENHI-PROJECT-26253062, KAKENHI-PROJECT-26670498, KAKENHI-PROJECT-15K15549
  • [Journal Article] Heterogeneity of HLH pathophysiology and treatment strategies2015

    • Author(s)
      八角高裕、柴田洋史、下寺佐栄子、平家俊男
    • Journal Title

      Rinsho Ketsueki

      Volume: 56 Issue: 10 Pages: 2248-2257

    • DOI

      10.11406/rinketsu.56.2248

    • NAID

      130005103313

    • ISSN
      0485-1439, 1882-0824
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-26461582, KAKENHI-PROJECT-25670475
  • [Journal Article] Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media.2014

    • Author(s)
      Fukuta M, Nakai Y, Kirino K, Nakagawa M, Sekiguchi K, Nagata S, Matsumoto Y, Yamamoto T, Umeda K, Heike T, Okumura N, Koizumi N, Sato T, Nakahata T, Saito M, Otsuka T, Kinoshita S, Ueno M, Ikeya M, Toguchida J.
    • Journal Title

      PLOS ONE

      Volume: 9 Issue: 12 Pages: e112291-e112291

    • DOI

      10.1371/journal.pone.0112291

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390353, KAKENHI-PROJECT-24590353, KAKENHI-PROJECT-24592272, KAKENHI-PROJECT-25293320, KAKENHI-PROJECT-25461591, KAKENHI-PROJECT-26253062, KAKENHI-PROJECT-26670498
  • [Journal Article] Aicardi-Goutières syndrome is caused by IFIH1 mutations.2014

    • Author(s)
      Oda, H., Nakagawa, K., Abe, J., Awaya, T., Funabiki, M., Hijikata, A., Nishikomori, R., Funatsuka, M., Ohshima, Y., Sugawara, Y., Yasumi, T., Kato, H., Shirai, T., Ohara, O., Fujita, T., Heike, T.
    • Journal Title

      America Journal of Human Genetics

      Volume: 95 Issue: 1 Pages: 121-125

    • DOI

      10.1016/j.ajhg.2014.06.007

    • NAID

      120005460706

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-24115004, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-25280109, KAKENHI-PROJECT-25670474
  • [Journal Article] A nationwide survey of Aicardi-Goutières syndrome patients identifies a strong association between dominant TREX1 mutations and chilblain lesions: Japanese cohort study.2014

    • Author(s)
      Abe J, Nakamura K, Nishikomori R, Kato M, Mitsuiki N, Izawa K, Awaya T, Kawai T, Yasumi T, Toyoshima I, Hasegawa K, Ohshima Y, Hiragi T, Sasahara Y, Suzuki Y, Kikuchi M, Osaka H, Ohya T, Ninomiya S, Fujikawa S, Akasaka M, Iwata N, Kawakita A, Funatsuka M, Shintaku H, Ohara O, Ichinose H, Heike T.
    • Journal Title

      Rheumatology

      Volume: 53 Issue: 3 Pages: 448-458

    • DOI

      10.1093/rheumatology/ket372

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249056
  • [Journal Article] Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes.2014

    • Author(s)
      Nakagawa K, Kawai T, Umebayashi H, Takei S, Kobayashi N, Yashiro M, Kubota T, Koike R, Akuta N, Shimoyama K, Iwata N, Saito MK, Ohara O, Kambe N, Yasumi T, Izawa K, Kawai T, Heike T, Yagüe J, Nishikomori R, Aróstegui JI et al.
    • Journal Title

      Ann Rheum Dis.

      Volume: in press Issue: 3 Pages: 1-8

    • DOI

      10.1136/annrheumdis-2013-204361

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23249056, KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-24590681, KAKENHI-PROJECT-25460838, KAKENHI-PROJECT-25461591, KAKENHI-PROJECT-26253062
  • [Journal Article] Real-time single-cell imaging of protein secretion2014

    • Author(s)
      Yamagishi, M. Suzuki, N. Izawa, K. Nakahara, A. Mizuno, J. Shoji, S. Heike, T. Harada, Y. Nishikomori, R. Ohara, O.
    • Journal Title

      Sci Rep

      Volume: 4 Issue: 1 Pages: 4736-4736

    • DOI

      10.1038/srep04736

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-25440074, KAKENHI-PUBLICLY-26115708, KAKENHI-PROJECT-26286028
  • [Journal Article] Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes.2013

    • Author(s)
      Nakagawa K, Gonzalez-Roca E, Souto A, Kawai T, Umebayashi H, Campistol JM, Cañellas J, Takei S, Kobayashi N, Callejas-Rubio JL, Ortego-Centeno N, Ruiz-Ortiz E, Rius F, Anton J, Iglesias E, Jimenez-Treviño S, Vargas C, Fernandez-Martin J, Calvo I, Hernández-Rodríguez J, Mendez M, Dordal MT, Basagaña M, Bujan S, Yashiro M, Kubota T, Koike R, Akuta N, Shimoyama K, Iwata N, Saito MK, Ohara O, Kambe N, Yasumi T, Izawa K, Kawai T, Heike T, Yagüe J, Nishikomori R, Aróstegui JI
    • Journal Title

      Ann Rheum Dis

    • Data Source
      KAKENHI-PROJECT-23249056
  • [Journal Article] Safety and efficacy of canakinumab in Japanese patients with phenotypes of cryopyrin-associated periodic syndrome as established in the first open-label, phase-3 pivotal study (24-week results)2013

    • Author(s)
      Imagawa T, Nishikomori R, Takada H, Takeshita S, Patel N, Kim D, Lheritier K, Heike T, Hara T, Yokota S
    • Journal Title

      Clin Exp Rheumatol

      Volume: 31 Pages: 302-309

    • Data Source
      KAKENHI-PROJECT-23249056
  • [Journal Article] Robust and highly-efficient differentiation of functional monocytic cells from human pluripotent stem cells under serum- and feeder cell- free conditions.2013

    • Author(s)
      Yanagimachi MD, Niwa A, Tanaka T, Ozaki F, Nishimoto S, Murata Y, Yasumi T, Ito J, Tomida S, Oshima K, Asaka I, Goto H, Heike T, Nakahata T, Saito MK
    • Journal Title

      PLoS ONE

      Volume: 8(4) Issue: 4 Pages: e59243-e59243

    • DOI

      10.1371/journal.pone.0059243

    • NAID

      120005244458

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-22591159, KAKENHI-PROJECT-23657147, KAKENHI-PROJECT-24659496, KAKENHI-PROJECT-24790997, KAKENHI-PROJECT-25461591
  • [Journal Article] Obvious optic disc swelling in a patient with cryopyrin-associated periodic syndrome2013

    • Author(s)
      Kawai M, Yoshikawa T, Nishikomori R, Heike T, Takahashi K
    • Journal Title

      Clin Ophthalmol

      Volume: 7 Pages: 1581-1585

    • Data Source
      KAKENHI-PROJECT-23249056
  • [Journal Article] Safety and efficacy of canakinumab in Japanese patients with phenotypes of cryopyrin-associated periodic syndrome as established in the first open-label, phase-3 pivotal study (24-week results)2013

    • Author(s)
      Imagawa, T. Nishikomori, R. Takada, H. Takeshita, S. Patel, N. Kim, D. Lheritier, K. Heike, T. Hara, T. Yokota, S.
    • Journal Title

      Clin Exp Rheumatol

      Volume: 31 Pages: 302-309

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390263
  • [Journal Article] Guidance on the use of canakinumab in patients with cryopyrin-associated periodic syndrome in Japan2013

    • Author(s)
      Yokota S, Nishikomori R, Takada H, Kikuchi M, Nozawa T, Kanetaka T, Kizawa T, Miyamae T, Mori M, Heike T, Hara T, Imagawa T
    • Journal Title

      Mod Rheumatol

      Volume: 23 Pages: 425-429

    • NAID

      10031175900

    • Data Source
      KAKENHI-PROJECT-23249056
  • [Journal Article] Selective development of myogenic mesenchymal cells from human embryonic and induced pluripotent stem cells2012

    • Author(s)
      AwayaT, Kato T, Mizuno Y, Chang H, Niwa A, Umeda K, Nakahata T, Heike T.
    • Journal Title

      PLoS One

      Volume: 7(12)

    • NAID

      120005122354

    • Data Source
      KAKENHI-PROJECT-23659520
  • [Journal Article] Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery2012

    • Author(s)
      Tanaka T., Takahashi K., Yamane M., Tomida S., Nakamura S., Oshima K., Niwa A., Nishikomori R., Kambe N., Hara H., Mitsuyama M., Morone N., Heuse J.E., Yamamoto T., Watanabe A., Sato-Otsubo A., Ozawa S., Asaka I., Heike T., Yamanaka S., Nak
    • Journal Title

      Blood

      Volume: 120(6) Issue: 6 Pages: 1299-308

    • DOI

      10.1182/blood-2012-03-417881

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-22790283, KAKENHI-PROJECT-23310087, KAKENHI-PROJECT-23390280, KAKENHI-PROJECT-23657147, KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-24590524, KAKENHI-PROJECT-24659496
  • [Journal Article] Detection of Base Substitution-Type Somatic Mosaicism of the NLRP3 Gene with> 99. 9% Statistical Confidence by Massively Parallel Sequencing2012

    • Author(s)
      Izawa, K., A. Hijikata, N. Tanaka, T. Kawai, M. K. Saito, R. Goldbach-Mansky, I. Aksentijevich, T. Yasumi, T. Nakahata, T. Heike, R. Nishikomori, and O. Ohara
    • Journal Title

      DNA Res

      Volume: 19 Issue: 2 Pages: 143-52

    • DOI

      10.1093/dnares/dsr047

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390310, KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-23657147, KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-24659496
  • [Journal Article] Detection of base substitution-type somatic mosaicism of the NLRP3 gene with >99. 9% statistical confidence by massively parallel sequencing2012

    • Author(s)
      Izawa K, Hijikata A, Tanaka N, Kawai T, Saito MK, Goldbach-Mansky R, Aksentijevich I, Yasumi T, Nakahata T, Heike T, Nishikomori R, Ohara O
    • Journal Title

      DNA Res

      Volume: 19 Pages: 143-152

    • Data Source
      KAKENHI-PROJECT-23249056
  • [Journal Article] Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery2012

    • Author(s)
      Tanaka T, Takahashi K, Yamane M, Tomida S, Nakamura S, Oshima K, Niwa A, Nishikomori R, Kambe N, Hara H, Mitsuyama M, Morone N, Heuser JE, Yamamoto T, Watanabe A, Sato-Otsubo A, Ogawa S, Asaka I, Heike T, Yamanaka S, Nakahata T, Saito MK
    • Journal Title

      Blood

      Volume: 120 Pages: 1299-1308

    • Data Source
      KAKENHI-PROJECT-23249056
  • [Journal Article] Selective development of myogenic mesenchymal cells from human embryonic and induced pluripotent stem cells2012

    • Author(s)
      Awaya T., Kato T., Mizuno Y., Chang H., Niwa A., Umeda K., Nakahata T., Heike T.
    • Journal Title

      PLoS ONE

      Volume: 7(12) Issue: 12 Pages: e51638-e51638

    • DOI

      10.1371/journal.pone.0051638

    • NAID

      120005122354

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-23659520, KAKENHI-PROJECT-23791170, KAKENHI-PROJECT-24591507, KAKENHI-PROJECT-24591508
  • [Journal Article] An approach to the patients with cryopyrin-associated periodic syndrome (CAPS) : a new biologic response modifier, canakinumab2012

    • Author(s)
      Yokota S, Kikuchi M, Nozawa T, Kizawa T, Kanetaka T, Miyamae T, Mori MA, Nishikomori R, Takata H, Heike T, Hara T, Imagawa T
    • Journal Title

      Nihon Rinsho Meneki Gakkai Kaishi

      Volume: 35 Pages: 23-29

    • NAID

      10030465541

    • Data Source
      KAKENHI-PROJECT-23249056
  • [Journal Article] Rapid diagnosis of familial hemophagocytic lymphohistiocytosis type 3 (FHL3) by flow cytometric detection of intraplatelet Munc 13-4 protein.2011

    • Author(s)
      Murata Y., Yasumi T., Shirakawa R., Izawa K., Sakai H., Abe J., Tanaka N., Kawai T., Oshima K., Saito M., Nishikomori R., Ohara O.、Ishii E., Nakahata T., Horiuchi H., Heike T.
    • Journal Title

      Blood

      Volume: 118 Issue: 5 Pages: 1225-1230

    • DOI

      10.1182/blood-2011-01-329540

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-22501009, KAKENHI-PROJECT-22591159, KAKENHI-PUBLICLY-23113702, KAKENHI-PUBLICLY-23121503
  • [Journal Article] Neutrophil differentiation from human-induced pluripotent stem cells2011

    • Author(s)
      Morishima T, Watanabe K, Niwa A, Fujino H, Matsubara H, Adachi S, Suemori H, Nakahata T, Heike T
    • Journal Title

      J Cell Physiol

      Volume: 226 Pages: 1283-1291

    • NAID

      40019064352

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390296
  • [Journal Article] Patient with neonatal-onset chronic hepatitis presenting with mevalonate kinase deficiency with a novel MVK gene mutation2011

    • Author(s)
      Tahara, M., H. Sakai, R. Nishikomori, T. Yasumi, T. Heike, I. Nagata, A. Inui, T. Fujisawa, Y. Shigematsu, K. Nishijima, K. Kuwakado, S. Watabe, and J. Kameyama
    • Journal Title

      Modern rheumatology the Japan Rheumatism Association

      Volume: 21 Issue: 6 Pages: 641-645

    • DOI

      10.1007/s10165-011-0442-7

    • NAID

      10030206205

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390310
  • [Journal Article] Neutrophil differentiation from human-induced pluripotent stem cells.2011

    • Author(s)
      Morishima T, Watanabe K, Niwa A, Fujino H, Matsubara H, Adachi S, Suemori H, Nakahata T, Heike T.
    • Journal Title

      J Cell Physiol. 226(5)

      Pages: 1283-1291

    • NAID

      40019064352

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390296
  • [Journal Article] Familial cases of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis syndrome2011

    • Author(s)
      Adachi, M., A. Watanabe, A. Nishiyama, Y. Oyazato, I. Kamioka, M. Murase, A. Ishida, H. Sakai, R. Nishikomori, and T. Heike
    • Journal Title

      The Journal of pediatrics

      Volume: 158 Issue: 1 Pages: 155-9

    • DOI

      10.1016/j.jpeds.2010.09.054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390310
  • [Journal Article] ヒトiPS細胞からの好中球分化誘導2011

    • Author(s)
      森嶋達也、平家俊男
    • Journal Title

      血液内科

      Volume: 63 Pages: 332-338

    • Data Source
      KAKENHI-PROJECT-21591360
  • [Journal Article] High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome2011

    • Author(s)
      Tanaka N, Izawa K, Saito MK, Sakuma M, Oshima K, Ohara O, Nishikomori R, Morimoto T, Kambe N, Goldbach-Mansky R, Aksentijevich I, de Saint Basile G, Neven B, van Gijn M, Frenkel J, Arostegui JI, Yague J, Merino R, Ibanez M, Pontillo A, Takada H, Imagawa T
    • Journal Title

      Arthritis Rheum

      Volume: 63 Issue: 11 Pages: 3625-32

    • DOI

      10.1002/art.30512

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390310, KAKENHI-PROJECT-21591363, KAKENHI-PUBLICLY-22021049, KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-23249056
  • [Journal Article] High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome2011

    • Author(s)
      Tanaka N, Izawa K, Saito MK, Sakuma M, Oshima K, Tanaka N, Izawa K, Saito MK, Sakuma M, Oshima K, Ohara O, Nishikomori R, Morimoto T, Kambe N, Goldbach-Mansky R, Aksentijevich I, de Saint Basile G, Neven B, van Gijn M, Frenkel J, Aróstegui JI, Yagüe J, Merino R, Ibañez M, Pontillo A, Takada H, Imagawa T, Kawai T, Yasumi T, Nakahata T, Heike T
    • Journal Title

      International Multicenter Collaborative Study

      Volume: 63 Pages: 3625-3632

    • Data Source
      KAKENHI-PROJECT-23249056
  • [Journal Article] A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors2011

    • Author(s)
      Niwa A, Heike T, Umeda K, et al.
    • Journal Title

      PloS One

      Volume: 6 Issue: 7 Pages: e22261-e22261

    • DOI

      10.1371/journal.pone.0022261

    • NAID

      120003324603

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591360, KAKENHI-PROJECT-22249042, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-22790979, KAKENHI-PROJECT-23591561, KAKENHI-PROJECT-23657147
  • [Journal Article] Hyperimmunoglobulinemia D and periodic fever syndrome2011

    • Author(s)
      Sakai H, Heike T
    • Journal Title

      Nihon Rinsho Meneki Gakkai Kaishi

      Volume: 34 Pages: 382-387

    • NAID

      10029898019

    • Data Source
      KAKENHI-PROJECT-23249056
  • [Journal Article] Hematopoietic stem cell transplantation with reduced intensity conditioning from a family haploidentical donor in an infant with familial hemophagocytic lymphohistocytosis2011

    • Author(s)
      Ohta H, Miyashita E, Hirata I, Matsumura R, Yoshida H, Hashii Y, Higashiura T, Yasumi T, Murata Y, Heike T, Yang X, Kanegane H, Ohara O, Ozono K
    • Journal Title

      Int J Hematol

      Volume: 94(3):285-90 Issue: 3 Pages: 285-290

    • DOI

      10.1007/s12185-011-0916-6

    • NAID

      10029694397

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591159
  • [Journal Article] Patient with neonatal-onset chronic hepatitis presenting with mevalonate kinase deficiency with a novel MVK gene mutation2011

    • Author(s)
      Tahara M, Sakai H, Nishikomori R, Yasumi T, Heike T, Nagata I, Inui A, Fujisawa T, Shigematsu Y, Nishijima K, Kuwakado K, Watabe S, Kameyama J
    • Journal Title

      Mod Rheumatol

      Volume: 21 Pages: 641-645

    • NAID

      10030206205

    • Data Source
      KAKENHI-PROJECT-23249056
  • [Journal Article] Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice.2010

    • Author(s)
      Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T.
    • Journal Title

      Cardiovasc Res. 88

      Pages: 315-322

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390296
  • [Journal Article] Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes.2010

    • Author(s)
      Nagai, N., Yamamoto, K., Fujiwara, H., An, J., Ochi, T., Suemori, K., Yasumi, T., Tauchi, H., Koh, K., Sato, M., Morimoto, A., Heike, T., Ishii, E., Yasukawa, M.
    • Journal Title

      PloS One

      Volume: 5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591159
  • [Journal Article] Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells.2010

    • Author(s)
      Mizuno Y, Chang H, Umeda K, Niwa A, Iwasa T, Awaya T, Fukuda S, Yamamoto H, Yamanaka S, Nakahata T, Heike T
    • Journal Title

      FASEB J 24

      Pages: 2245-2253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390296
  • [Journal Article] Cell line-dependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice2010

    • Author(s)
      Kaichi S, Hasegawa K, Takaya T, Yokoo N, Mima T, Kawamura T, Morimoto T, Ono K, Baba S, Doi H, Yamanaka S, Nakahata T, Heike T
    • Journal Title

      Cardiovasc Res

      Volume: 88 Pages: 315-322

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390296
  • [Journal Article] Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells2010

    • Author(s)
      Mizuno Y, Chang H, Umeda K, Niwa A, Iwasa T, Awaya T, Fukuda S, Yamamoto H, Yamanaka S, Nakahata T, Heike T
    • Journal Title

      FASEB J (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390296
  • [Journal Article] Subtypes of familial hemophagocytic lymphohistiocytosis in Japan based on genetic and functional analyses of cytotoxic T lymphocytes2010

    • Author(s)
      Nagai K, Yamamoto K, Fujiwara H, An J, Ochi T, Suemori K, Yasumi T, Tauchi H, Koh K, Sato M, Morimoto A, Heike T, Ishii E, Yasukawa M
    • Journal Title

      PLoS One

      Volume: 5(11):e14173 Issue: 11 Pages: e14173-e14173

    • DOI

      10.1371/journal.pone.0014173

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591159
  • [Journal Article] Selective infection of CD(4)+ effector memory T lymphocytes leads to preferential depletion of memory T lymphocytes in R5 HIV-infected humanized NOD/SCID/IL-2Rγnull mice.2009

    • Author(s)
      Nie C, Sato K, Misawa N, Kitayama H, Fujino H, Hiramatsu H, Heike T, Nakahata T, Tanaka Y, Ito M, Koyanagi Y
    • Journal Title

      Virology 394

      Pages: 64-72

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2。.2009

    • Author(s)
      Higashi A.Y., Ikawa T, Muramatsu M, Economides A.N., Niwa A, Okuda T, Murphy AJ., Rojas J, Heike T, Nakahata T, Kawamoto H, Kita T, Yanagita M.
    • Journal Title

      J Immunol. 182

      Pages: 5633-5640

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells.2009

    • Author(s)
      Chang H, Yoshimoto M, Umeda K, Iwasa T, Mizuno Y, Fukada SI, Yamamoto H, Motohashi N, Suzuki YM, Takeda S, Heike T, Nakahata T.
    • Journal Title

      FASEB J. 23

      Pages: 1907-1919

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Orderly Hematopoietic Development of Induced Pluripotent Stem Cells via Flk-1+ Hemoangiogenic Progenitors.2009

    • Author(s)
      Niwa A., Umeda K., Chang H., Saito M., Okita K., Takahashi K., Nakagawa M., Yamanaka S., Nakahata T., Heike T
    • Journal Title

      J. Cell. Physiol. 221

      Pages: 367-377

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.2009

    • Author(s)
      Miyara M., Yoshioka Y., Kitoh A., Shima T., Wing K., Niwa A., Perizot C., Taflin C., Heike T., Valeyre D., Mathian A., Nakahata T., Yamaguchi T., Nomura T., Ono M., Amoura Z., Gorochov G., Sakaguchi S.
    • Journal Title

      Immunity 30

      Pages: 899-911

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Orderly hematopoietic development of induced pluripotent stem cells via Flk-1(+) hemoangiogenic progenitors2009

    • Author(s)
      Niwa A, Umeda K, Heike T, et al.
    • Journal Title

      J Cell Physiol

      Volume: 221 Issue: 2 Pages: 367-377

    • DOI

      10.1002/jcp.21864

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591360
  • [Journal Article] Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells.2009

    • Author(s)
      Chang H, Yoshimoto M, Umeda K, Iwasa T, Mizuno Y, Fukuda S, Yamamoto H, Motohashi N, Suzuki Y, Takeda S, Heike T, Nakahata T
    • Journal Title

      FASEB J 23

      Pages: 1907-1919

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390296
  • [Journal Article] Orderly hematopoietic development of induced pluripotent stem cells via Flk-1 (+) hemoangiogenic progenitors.2009

    • Author(s)
      Niwa A, Umeda K, Chang H, Saito M, Okita K, Takahashi K, Nakagawa M, Yamanaka S, Nakahata T, Heike T
    • Journal Title

      J Cell Physiol 221

      Pages: 367-377

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390296
  • [Journal Article] Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells2009

    • Author(s)
      Chang H, Yoshimoto M, Umeda K, Iwasa T, Mizuno Y, Fukuda S, Yamamoto H, Motohashi N, Suzuki Y, Takeda S, Heike T, Nakahat T
    • Journal Title

      FASEB J 23

      Pages: 1907-1919

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390296
  • [Journal Article] Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis.2009

    • Author(s)
      Okafuji I, Nishikomori R, Kanazawa N, Kambe N, Fujisawa A, Yamazaki S, Saito M, Yoshioka T, Kawai T, Sakai H, Tanizaki H, Heike T, Miyachi Y, Nakahata T.
    • Journal Title

      Arthritis Rheum. 60

      Pages: 242-50

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] The effects of cardioactive drugs on cardiomyocytes derived from human induced pluripotent stem cells.2009

    • Author(s)
      Yokoo N., Baba S., Kaichi S., Niwa A., Mima T., Doi H., Yamanaka S., Nakahata T., Heike T.
    • Journal Title

      Biochem. Biophys. Res. Com. 387

      Pages: 482-488

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis2009

    • Author(s)
      Okafuji, I., Nishikomori, R., Kanazawa, N., Kambe, N., Fujisawa, A., Yamazaki, S., Saito, M., Yoshioka, T., Kawai, T., Sakai, H., Tanizaki, H., Heike, T., Miyachi, Y. & Nakahata, T.
    • Journal Title

      Arthritis Rheum

      Volume: 60 Issue: 1 Pages: 242-250

    • DOI

      10.1002/art.24134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390310
  • [Journal Article] Expression profile analysis of aorta-gonad-mesonephros region-derived stromal cells reveals genes that regulate hematopoiesis2008

    • Author(s)
      Nagao K, Ohta T, Tahara T, Hasiwara T, Naeda Y, Yoneyaya T, Sohma Y, Heike T, Nakahata T, Inagaki Y, Nishikawa M
    • Journal Title

      Biochem Biophys Res Commun 377

      Pages: 205-209

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390296
  • [Journal Article] Direct development of functionary mature tryptase/ chymase double-positive connective tissue-type mast cells from primate embryonic stem cells.2008

    • Author(s)
      Ma F, Kambe N, Dan W, Shinoda G, Fujino H, Umeda K, Fujisawa A, Ma L, Suemori H, Nakatsuji N, Miyachi Y, Torii R, Tsuji K, Heike T, Nakahata T
    • Journal Title

      Stem Cells 26

      Pages: 706-714

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Sca-1+ endothelial cells (SPECs) reside in the portal area of the liver and contribute to rapid recovery from acute liver disease.2008

    • Author(s)
      Tsuchiya A., Heike T., Baba S., Fujino H., Umeda K., Matsuda Y., Nomoto M., Ichida T., Aoyagi Y., Nakahata T.
    • Journal Title

      Biochem. Biophys. Res. Com. 365

      Pages: 595-601

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Expression profile analysis of aorta-gonad-mesonephros region-derived stromal cells reveals genes that regulate hematopoiesis2008

    • Author(s)
      80. Nagao K, Ohta T, Tahara T, Hasiwara T, Naeda Y, Yoneyaya T, Sohraa Y, Heike T, Nakahata T, Inagaki Y, Nishikawa M
    • Journal Title

      Biochem Biophys Res Commun 377

      Pages: 205-209

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659264
  • [Journal Article] Expression profile analysis of aorta-gonad-mesonephros region-derived stromal cells reveals genes that regulate hematopoiesis.2008

    • Author(s)
      Nagao K, Ohta T, Tahara T, Hasiwara T, Naeda Y, Yoneyaya T, Sohma Y, Heike T, Nakahata T, Inagaki Y, Nishikawa M
    • Journal Title

      Biochem Biophys Res Commun 377

      Pages: 205-209

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390296
  • [Journal Article] Side population cells contribute to the genesis of human endometrium.2008

    • Author(s)
      Tsuji S, Yoshimoto M, Takahashi K, Noda Y, Nakahata T, Heike T
    • Journal Title

      Fertility and Sterility 90

      Pages: 1528-1537

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients.2008

    • Author(s)
      Saito M., Nishikomori R., Kambe N., Fujisawa A., Tanizaki H., Takeichi K., Imagawa T., Iehara T., Takada H., Matsubayashi T., TanakaH., Kawashima K., Kagami S., Kawai T., Okafuji I., Yoshioka T., Adachi S., Heike T., Miyachi Y., Nakahata T.
    • Journal Title

      Blood 111

      Pages: 2132-2141

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality.2008

    • Author(s)
      Yamanaka Y., Kumada T., Heike T., Shibata M., Takaoka Y., Kitano A., Shiraishi K., Kato T., Nagato M., Okawa K., Furushima K., Nakao K., Aizawa S., Nakamura Y., Taketo M.M. Nakahata T.
    • Journal Title

      Mech. Develop. 125

      Pages: 4441-450

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Generation of Cardiac and Endothelial Cells from Neonatal Mouse Testis-derived Multipotent Germline2007

    • Author(s)
      Baba S, Heike T
    • Journal Title

      Stem Cells 25

      Pages: 1375-1383

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] a4 integrin+ endothelium derived from primate embryonic stem cells generates both primitive and definitive hematopoietic cells2007

    • Author(s)
      Shinoda, G., Umeda, K., Heike, T., Arai, M., Niwa, A., Ma, F., Suemori, H., Luo, HY., HK., Chui, D., Torii, R., Shibuya, M., Nakatsuji, N., Nakahata, T
    • Journal Title

      Blood 109

      Pages: 2406-2415

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] Novel method for efficient production of multipotential hematopoietic progenitors from human embryonic stem cells.2007

    • Author(s)
      Ma F., Wang D., Hanada S., Ebihara Y., Kawasaki H., Zaike Y., Heike T., Nakahata T., Tsuji K.
    • Journal Title

      Int. Hematol. 85

      Pages: 371-379

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells.2007

    • Author(s)
      Fujisawa A, Kambe N, Saito M, Nishikomori R, Tanizaki H, Kanazawa N, Adachi S, Heike T, Sagara J, Suda T, Nakahata T, Miyachi Y
    • Journal Title

      Blood 109(7)

      Pages: 2903-2911

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Flkl(+) cardiac stem/ progenitor cells derived from embryonic stem cells improve cardiac function in a dilated cardiomyopathy mouse model2007

    • Author(s)
      Baba S, Heike T, et. al.
    • Journal Title

      Cardiovasc Res 79

      Pages: 119-131

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659264
  • [Journal Article] Generation of Cardiac and Endothelial Cells from Neonatal Mouse Testis-derived Multipotent Germline Stem Cells2007

    • Author(s)
      Baba S, Heike T, et. al.
    • Journal Title

      Stem Cells 25

      Pages: 1375-1383

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] a4 integrin+endothelium derived from primate embryonic stem cells generates both primitive and definitive hematopoietic cells.2007

    • Author(s)
      Shinoda G, Heike T, et. al.
    • Journal Title

      Blood 109

      Pages: 2406-2415

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] α4-Integrin+ endothelium deriverd from primate embryonic stem cells generates primitive and definitive hematopoietic cells.2007

    • Author(s)
      Shinoda G, Umeda K, Heike T, Arai M, Niwa A, Ma F, Suemori H, Luo HY, Chui DH, Torii R, Shibuya M, Nakatsuji N, Nakahata T
    • Journal Title

      Blood 109(6)

      Pages: 2406-2415

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Flkl(+) cardiac stem/ progenitor cells derived from embryonicstem cells improve cardiac function in a dilated cardiomyopathy mouse model2007

    • Author(s)
      Baba S, Heike T, et. al.
    • Journal Title

      Cardiovasc Res 79

      Pages: 119-131

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/γcnull mice through cell fusion.2007

    • Author(s)
      Fujino H, Heike T
    • Journal Title

      FASEB J 21

      Pages: 3499-3510

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] Generation of Cardiac and Endothelial Cells from Neonatal Mouse Testis-derived Multipotent Germline2007

    • Author(s)
      Baba, S., Heike, T., Umeda, K., Iwasa, T., Kaichi, S., Hiraumi, Y., Doi, H., Yoshimoto, M., Kanatsu-Shinohara, M., Shinohara, T., Nakahata, T
    • Journal Title

      Stem Cells 25

      Pages: 1375-1383

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] Isolation and characterization of bone marrow-derived mesenchymal progenitor cells with myogenic and neuronal properties.2007

    • Author(s)
      Shiota M, Heike T, at. al.
    • Journal Title

      Exp Cell Res 313

      Pages: 1008-1023

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] Novel method for efficient production of multipotential hematopoietic progenitors from human embryonic stem cells2007

    • Author(s)
      Ma F, , Heike T, et. al.
    • Journal Title

      Int J Hematol 85

      Pages: 371-379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] ヒトes細胞を用いた造血幹細胞や神経幹細胞への分化誘導.2007

    • Author(s)
      平家俊男, 梅田雄嗣, 加藤竹雄, 中畑龍俊
    • Journal Title

      医学のあゆみ 220(2)

      Pages: 186-190

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Generation of Cardiac and Endothelial Cells from Neonatal Mouse Testis-Derived Multipotent Germline Stem Cells.2007

    • Author(s)
      Baba S, Heike T, Umeda K, Iwasa T, Kaichi S, Hiraumi T, Doi H, Yoshimoto M, Kanatsu-Shinohata M, Shinohara T, Nakahata T
    • Journal Title

      Stem Cells 25

      Pages: 1375-1383

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Isolation and characterization of bone marrow-derived mesenchymal progenitor cells with myogenic and neuronal properties2007

    • Author(s)
      Shiota M, Heike T et al.
    • Journal Title

      Exp Cell Res 313

      Pages: 1008-1023

    • Data Source
      KAKENHI-PROJECT-17659314
  • [Journal Article] Efficient Assay for Evaluating human thrombopoiesis using NOD/SCID mice transplanted with cord blood CD34+ cells.2007

    • Author(s)
      Suzuki K, Hiramatsu H, Fukushima-Shintani M, Heike T, Nakahata T.
    • Journal Title

      Eur J Haematol 78

      Pages: 123-130

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gcnull mice through cell fusion.2007

    • Author(s)
      Fujino H, Hiramatsu H, Tsuchiya A, Niwa A, Noma H, Shiota M, Umeda K, Yoshimoto M, Ito M, Heike T, Nakahata T.
    • Journal Title

      FASEB J. 21

      Pages: 3499-3510

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Long-term culture of postnatal mouse hepatic stem/ progenitor cells and their relative development hierarchy.2007

    • Author(s)
      Tsuchiya A, Heike T, Baba S, Fujino H, Umeda K, Matsuda Y, Nomoto M, Ichida T, AoyagiY, Nakahata T
    • Journal Title

      Stem Cells 25

      Pages: 895-902

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Isolation and characterization of bone marrow-derived mesenchymal progenitor cells with myogenic and neuronal properties2007

    • Author(s)
      Shiota, M., Heike, T., Haruyama, M., Baba, S., Tsuchiya, A., Fujino, H., Kobayashi, H., Kato, T., Umeda, K., Yoshimoto, M., Nakahata, T
    • Journal Title

      Exp Cell Res 313

      Pages: 1008-1023

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] Novel method for efficient production of multipotential hematopoietic progenitors from human embryonic stem cells2007

    • Author(s)
      Ma F, , Heike T, et. al.
    • Journal Title

      Int J Hematol 85

      Pages: 371-379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659264
  • [Journal Article] Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/ycnull mice through cell fusion2007

    • Author(s)
      Fujino, H., Hiramatsu, H., Tsuchiya, A., Niwa, A., Noma, H., Shiota, M., Umeda, K., Yoshimoto, M., Ito, M., Heike, T., Nakahata, T
    • Journal Title

      FASEB J 21

      Pages: 3499-3510

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] Isolation and characterization of bone marrow-derived mesenchymal progenitor cells with myogenic and neuronal properties.2007

    • Author(s)
      Shiota M, Heike T, Haruyama M, Baba S, Tsuchiya A, Fujino H, Kobayashi H, Umeda K, Yoshimoto M, Nakahata T
    • Journal Title

      Exp Cell Res. 313(5)

      Pages: 1008-1023

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] a4 integrin+ endothelium derived from primate embryonic stem cells generates both primitive and definitive hematopoietic cells2007

    • Author(s)
      Shinoda G, Heike T, et. al.
    • Journal Title

      Blood 109

      Pages: 2406-2415

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659264
  • [Journal Article] Flk1+ cardiac stem/progenitor cells derived from embryonic stem cells improve cardiac function in a dilated cardiomyopathy mouse model.2007

    • Author(s)
      Baba S, Heike T, Yoshimoto M, Umeda K, Doi H, Iwasa T, Lin X, Matsuoka S, Komeda M, Nakahata T
    • Journal Title

      Cardiiovascular Res. 76

      Pages: 119-131

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Identification and characterization of hemangiogenic progenitors during cynomolous monkey embryonic stem cell differentiation2006

    • Author(s)
      Umeda, K., Heike, T., Yoshimoto, M., Shinoda, G., Shiota, M., Suemori, H., Luo, HY., Chui, DHK., Torii, It., Shibuya, M., Nakatsuji, N., Nakahata, T
    • Journal Title

      Stem Cells 24

      Pages: 1348-1358

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] Sequential analysis of a-and b-globin gene expression during erythropoietic differentiation from primate embryonic stem cells.2006

    • Author(s)
      Umeda K, Heike T, et. al.
    • Journal Title

      Stem Cells 24

      Pages: 2627-2636

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] Sequential analysis of a- and b-globin gene expression during erythropoietic differentiation from primate embryonic stem cells2006

    • Author(s)
      Umeda K, Heike T, et al.
    • Journal Title

      Stem Cells 24

      Pages: 2627-2636

    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] Sequential analysis of a- and b-globin gene expression during erythropoietic differentiation from primate embryonic stem cells2006

    • Author(s)
      Umeda, K., Heike, T., Nakata-Hizume, M., Niwa, A., Arai, M., Shinoda, G., Ma, F., Suemori, H., Luo, HY., Chui, DH., Torn, It., Shibuya, M., Nakatsuj,i N., Nakahata, T
    • Journal Title

      Stem Cells 24

      Pages: 2627-2636

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] Identification and characterization of hemangiogenic progenitors during cynomolous monkey embryonic stem cell differentiation.2006

    • Author(s)
      Umeda K, Heike T, et. al.
    • Journal Title

      Stem Cells 24

      Pages: 1348-1358

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] Identification and characterization of hemangiogenic progenitors during cynomolous monkey embryonic stem cell differentiation2006

    • Author(s)
      Umeda K, Heike T, et al.
    • Journal Title

      Stem Cells 24

      Pages: 1348-1358

    • Data Source
      KAKENHI-PROJECT-18390298
  • [Journal Article] Stem cell plasticity in hematopoietic system2005

    • Author(s)
      Heike T
    • Journal Title

      Inflamation and Regeneration 25

      Pages: 90-90

    • NAID

      10011958317

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Journal Article] Stem cell plasticity in hematopoietic system2005

    • Author(s)
      Heike T., Nakahata T.
    • Journal Title

      Inflammation and Regeneration 25

      Pages: 90-101

    • NAID

      10011958317

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390300
  • [Journal Article] SPINK5 polymorphism is associated with disease severity and food allergy in children with atopic dermatitis.2005

    • Author(s)
      Kusunoki, T., Okafuji I., Yoshioka T., Saito M., Nishikomori R., Heike T., Shimizu A., Nakahata T.
    • Journal Title

      J.Allergy Clin.Immunol 115

      Pages: 636-638

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Journal Article] Prospective characterization of neural stem cells by flow cytometry anakysis using a combination of surface markers.2005

    • Author(s)
      Nagato M., Heike T., Kato T., Yamanaka Y., Yoshimoto M., Shimazaki T., Okano H., Nakahata T.
    • Journal Title

      J Neurosci Res 80

      Pages: 456-466

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390300
  • [Journal Article] Stem cell plasticity in hematopoietic system2005

    • Author(s)
      Heike T
    • Journal Title

      Inflammation and Regeneration 25

      Pages: 90-101

    • NAID

      10011958317

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390300
  • [Journal Article] Two different roles of purified CD45+ c-kit+ Sca-1+ Lin- cells after transplantation in muscles.2005

    • Author(s)
      Yoshimoto M., Chang H., Shiota M., Kobayashi H., Umeda K., Kawakami A., Heike T., Nakahata T.
    • Journal Title

      Stem Cells 23

      Pages: 610-618

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390300
  • [Journal Article] Early-onset sarcoidosis and CARD15 mutations : common genetic etiology with Blau syndrome.2005

    • Author(s)
      Kanazawa N., Nishikomori R., Kambe N., Nakata-Hizume M., Okafuji I., Nagai S., Fuji A., Yuasa T., Utani A., Manki A., Sakurai Y., Nakajima M., Kobayashi H., Nishigori C., Heike T., Nakahata T., Miyachi Y.
    • Journal Title

      Blood 105

      Pages: 1195-1197

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Journal Article] Limited ability of antigen-specific Th1 responses to inhibit Th2 cell development in vivo.2005

    • Author(s)
      Yasumi T, Katamura K., Okafuji I., Yoshioka T., Meguro T., Nishikomori R., Kusunoki T., Heike T., Nakahata T.
    • Journal Title

      J.Immunol. 177

      Pages: 1325-1331

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Journal Article] Stem cell plasticity in hematopoietic system2005

    • Author(s)
      Heike T
    • Journal Title

      Inflamation and Regeneration 25

      Pages: 90-90

    • NAID

      10011958317

    • Data Source
      KAKENHI-PROJECT-16390300
  • [Journal Article] Identification of cardiac stem cells with FLK1, CD31, and VE-cadherin expression during embryonic stem cell differentiation.2005

    • Author(s)
      Iida M., Heike T., Yoshimoto M., Baba S., Doi H., Nakahata T.
    • Journal Title

      FASEB J. 19

      Pages: 371-378

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390300
  • [Journal Article] Differential requirement of the CD40-CD154 costimulatory pathway during T helper cell proming by CD8alpha+ and CD8alpha- murine dendritic cell subsets2004

    • Author(s)
      Yasumi T, Heike T et al.
    • Journal Title

      J Immunol 172

      Pages: 4826-4833

    • Data Source
      KAKENHI-PROJECT-15039219
  • [Journal Article] Generation of pluripotent stem cells from neonatal mouse testis2004

    • Author(s)
      Nakatsu-Shinohara M, Heike T et al.
    • Journal Title

      Cell 119

      Pages: 1001-1012

    • Data Source
      KAKENHI-PROJECT-15039219
  • [Journal Article] Differential requirement of the CD40-CD154 costimulatory pathway during T helper cell proming by CD8alpha+ and CD8alpha- murine dendritic cell subsets2004

    • Author(s)
      Yasumi T, Heike T et al.
    • Journal Title

      J Immunol 172

      Pages: 4826-4833

    • Data Source
      KAKENHI-PROJECT-16390300
  • [Journal Article] Stem cell plasticity in hematopoietic system2004

    • Author(s)
      Heike T, Nakahata T
    • Journal Title

      Int J Hematol 79

      Pages: 7-14

    • NAID

      10011958317

    • Data Source
      KAKENHI-PROJECT-16390300
  • [Journal Article] Role of bone marrow-derived progenitor cells in cuff-induced vascular injury in mice.2004

    • Author(s)
      Xu Y., Arai H., Zhuge X., Sano H., Murayama T., Yoshimoto M., Heike T., Nakahata T., Nishikawa S., Kita T., Yokode M.
    • Journal Title

      Arterioscl.Throm.Vas. 24

      Pages: 477-482

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Journal Article] Stem cell plasticity hematopoietic system2004

    • Author(s)
      Heike T, Nakahata T
    • Journal Title

      Int J Hematol 79

      Pages: 7-14

    • NAID

      10011958317

    • Data Source
      KAKENHI-PROJECT-15659245
  • [Journal Article] Stem cell plasticity in hematopoietic system2004

    • Author(s)
      Heike T, Nakahata T
    • Journal Title

      Int J Hematol 79

      Pages: 7-14

    • NAID

      10011958317

    • Data Source
      KAKENHI-PROJECT-15039219
  • [Journal Article] X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival2004

    • Author(s)
      Nishikomori R, Heike T et al.
    • Journal Title

      Blood 103

      Pages: 4565-4572

    • Data Source
      KAKENHI-PROJECT-15659245
  • [Journal Article] Generation of pluripotent stem cells from neonatal mouse testis.2004

    • Author(s)
      Kanatsu-Shinohara M., Inoue K., Lee J., Yoshimoto M., Ogonuki N., Miki H., Baba S., Kato T., Kazuki Y., Toyokuni S., Toyoshima M., Niwa O., Oshimura M., Heike T., Nakahata T., Ishino F., Ogura A., Shinohara T.
    • Journal Title

      Cell 119

      Pages: 1001-1012

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390300
  • [Journal Article] Development of primitive and definitive hemayopoiesis from nonhuman primate embryonic stem cells in vitro.2004

    • Author(s)
      Umeda K., Heike T., Yoshimoto M., Shiota M., Suemori H., Luo H.Y., Chui D.H.K., Shibuya M., Nakatsuji N., Nakahata T.
    • Journal Title

      Development 131

      Pages: 1869-1879

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Journal Article] Generation of multipotent stem cells from postnatal mouse testis.2004

    • Author(s)
      Kanatsu-Shinohara M., Inoue K., Lee J., Yoshimoto M., Ogonuki N., Miki H., Baba T., Kazuki Y., Toyokuni S., Oshimura M., Heike T., Nakahata T., Ishino F., Ogura A., Shinohara T.
    • Journal Title

      Cell 119

      Pages: 1001-1012

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Journal Article] Development of primitive and definitive hematopoiesis from nonhuman primate embryonic ste cells in vitro2004

    • Author(s)
      Umeda K, Heike T et al.
    • Journal Title

      Development 131

      Pages: 1869-1879

    • Data Source
      KAKENHI-PROJECT-15659245
  • [Journal Article] Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body2004

    • Author(s)
      Kambe N, Heike T et al.
    • Journal Title

      Blood 103

      Pages: 860-867

    • Data Source
      KAKENHI-PROJECT-15039219
  • [Journal Article] Development of primitive and definitive hematopoiesis from nonhuman primate embryonic ste cells in vitro2004

    • Author(s)
      Umeda K, Heike T et al.
    • Journal Title

      Development 131

      Pages: 1869-1879

    • Data Source
      KAKENHI-PROJECT-15039219
  • [Journal Article] Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body2004

    • Author(s)
      Kambe N, Heike T et al.
    • Journal Title

      Blood 103

      Pages: 860-867

    • Data Source
      KAKENHI-PROJECT-16390300
  • [Journal Article] Generation of pluripotent stem cells from neonatal mouse testis2004

    • Author(s)
      Nakatsu-Shinohara M, Heike T et al.
    • Journal Title

      Cell 119

      Pages: 1001-1012

    • Data Source
      KAKENHI-PROJECT-15659245
  • [Journal Article] X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival2004

    • Author(s)
      Nishikomori R, Heike T et al.
    • Journal Title

      Blood 103

      Pages: 4565-4572

    • Data Source
      KAKENHI-PROJECT-15039219
  • [Journal Article] X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival.2004

    • Author(s)
      Nishikomori R., Akutagawa H., Maruyama K., Nakata-Hizume M., Ohmori K., Mizuno K., Yachie A., Yasumi T., Kusunoki T., Heike T., Nakahata T.
    • Journal Title

      Blood 103

      Pages: 4565-4572

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Journal Article] Development of primitive and definitive hematopoiesis from nonhuman primate embryonic ste cells in vitro2004

    • Author(s)
      Umeda K, Heike T et al.
    • Journal Title

      Development 131

      Pages: 1869-1879

    • Data Source
      KAKENHI-PROJECT-16390300
  • [Journal Article] Generation of pluripotent stem cells from neonatal mouse testis2004

    • Author(s)
      Nakatsu-Shinohara M, Heike T et al.
    • Journal Title

      Cell 119

      Pages: 1001-1012

    • Data Source
      KAKENHI-PROJECT-16390300
  • [Journal Article] Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body.2004

    • Author(s)
      Kambe N., Hiramatsu H., Shimonaka M., Fujino H., Nishikomori R., Heike T., Ito M., Kobayashi K., Ueyama Y., Matsuyoshi N., Miyachi Y., Nakahata T.
    • Journal Title

      Blood 103

      Pages: 860-867

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Journal Article] Identification of cardiac stem cells with FLK1 expression during embryonic stem cell differentiation.2004

    • Author(s)
      Iida M., Heike T., Yoshimoto M., Baba S., Doi H., Nakahata T.
    • Journal Title

      FASEB J. 19

      Pages: 371-378

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Journal Article] Differential requirement of the CD40-CD154 costimulatory pathway during T helper cell proming by CD8alpha+ and CD8alpha- murine dendritic cell subsets2004

    • Author(s)
      Yasumi T, Heike T et al.
    • Journal Title

      J Immunol 172

      Pages: 4826-4833

    • Data Source
      KAKENHI-PROJECT-15659245
  • [Journal Article] X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival2004

    • Author(s)
      Nishikomori R, Heike T et al.
    • Journal Title

      Blood 103

      Pages: 4565-4572

    • Data Source
      KAKENHI-PROJECT-16390300
  • [Journal Article] Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body2004

    • Author(s)
      Kambe N, Heike T et al.
    • Journal Title

      Blood 103

      Pages: 860-867

    • Data Source
      KAKENHI-PROJECT-15659245
  • [Journal Article] Stem cell plasticity in hematopoietic system2002

    • Author(s)
      Heike T
    • Journal Title

      Inflamation and Regeneration 25

      Pages: 90-90

    • NAID

      10011958317

    • Data Source
      KAKENHI-PROJECT-17659314
  • [Journal Article] Two different role of purified Cd45+ hematopoietic stem cells after transplantation in muscles.

    • Author(s)
      Yoshimoto M., Heike T., Shiota M., Kobayashi H., Umeda K., Nakahata T.
    • Journal Title

      Stem Cells (in press)

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Journal Article] Characterization of mouse hepatic stem/progenytor cells in a novel culture system.

    • Author(s)
      Tsuchiya A., Heike T., Fujino H., Shiota M., Umeda K., Yoshimoto M., Matsuda Y., Ichida T., Aoyagi Y., Nakahata T.
    • Journal Title

      Gastroenterology (in press)

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Journal Article] Acetylation of GATA-4 is involved in the differentiation of embryonic stem cells into cardiac myocytes.

    • Author(s)
      Kawamura T., Ono K., Morimoto T., Wada H., Hirai M., Hidaka K., Morisaki T., Heike T., Nakahata T., Kita T., Hasegawa K.
    • Journal Title

      J.Biol.Chem. (in press)

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Journal Article] Generation of skeletal muscle stem/progenitor cells from murine induced pluripotent stem cells.

    • Author(s)
      Mizuno Y., Chang H., Umeda K., Niwa A., IwasaT., Awaya T., Fukada S., Hiroshi Yamamoto H., Yamanaka S., Nakahata T., Heike T.
    • Journal Title

      FASEB J. (in press)

    • Data Source
      KAKENHI-PROJECT-19109006
  • [Journal Article] Prospective characterization of neural stem cells by flow cytometry analysis using combination of the surface markers.

    • Author(s)
      Nagato M., Heike T., Kato T., Yamanaka Y., Yoshimoto M., Shimazaki T., Okano H., Nakahata T.
    • Journal Title

      J.Neurosci.Res. (in press)

    • Data Source
      KAKENHI-PROJECT-13GS0009
  • [Patent] 軟骨過形成疾患の予防および治療剤ならびにそのスクリーニング方法2014

    • Inventor(s)
      戸口田 淳也/西小森 隆太/横山 宏司/池谷 真/平家 俊男
    • Industrial Property Rights Holder
      戸口田 淳也/西小森 隆太/横山 宏司/池谷 真/平家 俊男
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-227500
    • Filing Date
      2014-11-07
    • Data Source
      KAKENHI-PROJECT-24390263
  • [Patent] 軟骨過形成疾患の予防および治療剤ならびにそのスクリーニング方法2014

    • Inventor(s)
      戸口田 淳也/西小森 隆太/横山 宏司/池谷 真/平家 俊男
    • Industrial Property Rights Holder
      戸口田 淳也/西小森 隆太/横山 宏司/池谷 真/平家 俊男
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-227500
    • Filing Date
      2014-11-07
    • Data Source
      KAKENHI-PROJECT-26253062
  • [Presentation] PFAPAの臨床像で発症し、長期経過後に腸管炎症、陰部潰瘍を合併したため診断に至った孤発性のTNFA1P3異常症の1例2016

    • Author(s)
      本田吉孝, 河合朋樹, 西小森隆太, 八角高裕, 井澤和司, 日衛嶋栄太郎, 中川権史, 柴田洋史, 下寺佐栄子, 大音泰介, 芝剛, 仁平寛士, 小田紘嗣, 小原收, 平家俊男
    • Organizer
      小児リウマチ学会
    • Place of Presentation
      千葉
    • Year and Date
      2016-10-21
    • Data Source
      KAKENHI-PROJECT-15H04876
  • [Presentation] 本邦でのメバロン酸キナーゼ欠損症のまとめ2016

    • Author(s)
      田中孝之, 西小森隆太, 中川権史, 井澤和司, 河合朋樹, 八角高裕, 平家俊男
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      横浜
    • Year and Date
      2016-04-21
    • Data Source
      KAKENHI-PROJECT-15H04876
  • [Presentation] 家族性血球貪食症候群(FHL)3型における迅速診断系・機能解析系の確立2016

    • Author(s)
      柴田洋史、八角高裕、日衛嶋栄太郎、中川権二、井澤和司、河合朋樹、小原收、平家俊男
    • Organizer
      第44回日本臨床免疫学会総会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-09-08
    • Data Source
      KAKENHI-PROJECT-26461582
  • [Presentation] 本邦でのメバロン酸キナーゼ欠損症のまとめ2015

    • Author(s)
      田中孝之, 吉岡耕平, 酒井秀政, 西小森隆太, 阿部純也, 日衛嶋栄太郎, 小原收, 河合朋樹, 八角高裕, 平家俊男
    • Organizer
      日本小児リウマチ学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2015-10-09
    • Data Source
      KAKENHI-PROJECT-15H04876
  • [Presentation] Understanding the pathophysiology of NOMID arthropathy for drug discovery by iPSCs technology.2015

    • Author(s)
      Nakagawa K., Okuno Y., Nishikomori R., Yokoyama K., Tanaka T., Kawai T., Yasumi T., Umeda K., Nakayama N., Toguchida J., Hagiwara M., Heike T.
    • Organizer
      8th International Society of Systemic Autoinflammatory Diseases Meeting 2015 (2015)
    • Place of Presentation
      Dresden, Germany
    • Year and Date
      2015-09-29
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04876
  • [Presentation] CD57+ CTL degranulation and Munc13-4 protein expression assays are sensitive and reliable screening methods for FHL32015

    • Author(s)
      Kikuya A, Hori M, Yasumi T, Hiejima E, Shibata H, Izawa K, Oda H, Nishikomori R, Ohara O, Heike T
    • Organizer
      第11回アジア小児研究学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-04-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25670475
  • [Presentation] Aicardi-Goutieres syndrome is caused by IFIH1 mutations2014

    • Author(s)
      Oda, H. Nakagawa, K. Abe, J. Awaya, T. Funabiki, M. Hijikata, A. Nishikomori, R. Funatsuka, M. Ohshima, Y. Sugawara, Y. Yasumi, T. Kato, H. Shirai, T. Ohara, O. Fujita, T. Heike, T.
    • Organizer
      American Society of Human Genetics
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-10-09
    • Data Source
      KAKENHI-PROJECT-24390263
  • [Presentation] 己炎症性疾患診療の新展開~ベンチサイドとベッドサイドの連携2014

    • Author(s)
      平家俊男
    • Organizer
      第71回日本小児科学会滋賀地方会
    • Place of Presentation
      滋賀医科大学
    • Year and Date
      2014-05-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-26253062
  • [Presentation] Understanding the pathology of the arthropathy in chronic infantile neurological cutaneous and articular syndrome by using iPS cells technology2013

    • Author(s)
      横山宏司、西小森隆太、池谷真、那須輝、田中孝之、齋藤潤、梅田雄嗣、中畑龍俊、平家俊男、戸口田淳也
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-24390263
  • [Presentation] 患者由来iPS細胞を用いたCINCA症候群における関節病態の分子機構の解明2013

    • Author(s)
      横山宏司、西小森隆太、池谷真、那須輝、田中孝之、齋藤潤、梅田雄嗣、中畑龍俊、平家俊男、戸口田淳也
    • Organizer
      第34回日本炎症再生医学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24390263
  • [Presentation] 自己炎症性疾患における診療研究の新展開~"炎症"と小児発熱性疾患~2013

    • Author(s)
      平家俊男
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-04-12
    • Data Source
      KAKENHI-PROJECT-23249056
  • [Presentation] 自己炎症性疾患の包括的把握に向けた臨床研究体制の整備について2013

    • Author(s)
      平家俊男
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Year and Date
      2013-04-20
    • Data Source
      KAKENHI-PROJECT-23249056
  • [Presentation] 自己炎症性疾患の包括的把握に向けた臨床研究体制の整備について2013

    • Author(s)
      平家俊男
    • Organizer
      日本小児科学会学術集会シンポジウム
    • Place of Presentation
      広島
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249056
  • [Presentation] Muckle-Wells症候群におけるNLRP3体細胞モザイク変異の検討2013

    • Author(s)
      中川権史、西小森隆太、井澤和司、河合朋樹、八角高裕、河合利尚、梅林宏明、武井修治、小林法元、小原收、Eva Gonzalez-Roca、Juan I. Arostegui、平家俊男
    • Organizer
      第23回日本小児リウマチ学会総会
    • Place of Presentation
      大宮
    • Data Source
      KAKENHI-PROJECT-24390263
  • [Presentation] Cryopyrin-associated periodic syndromeの治療 本邦におけるcanakinumab臨床試験及びアナキンラ疫学調査について2012

    • Author(s)
      酉小森隆太、井澤和司、河合朋樹、八角高裕、平家俊男
    • Organizer
      第40回日本臨床免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-28
    • Data Source
      KAKENHI-PROJECT-24390263
  • [Presentation] Diagnosis of nlrp3 somatic mosaicism incinca/nomid patients using next-generation sequencing : Poster Session, Board P292 : 18thEuropean Pediatric Rheumatology Congress2011

    • Author(s)
      K. Izawa, A. Hijikata, R. Nishikomori, O. Ohara, J. Abe, N. Tanaka, M. K. Saito, R. Goldbach-Mansky, I. Aksentijevich, T. Kawai, T. Yasumi, T. Nakahata, T. Heike
    • Organizer
      September
    • Place of Presentation
      Bruges, Belgium
    • Data Source
      KAKENHI-PROJECT-21390310
  • [Presentation] Rapid detection ofNLRP3 somatic mosaicism using next-generation sequencing2011

    • Author(s)
      井澤和司、西小森隆太、八角高裕、平家俊男、土方敦司、小原收
    • Organizer
      第56回日本人類遺伝学会・第11回東アジア人類遺伝学会共同大会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-21390310
  • [Presentation] 患者特異的iPS細胞を用いたCINCA症候群体細胞モザイクの病態解明2011

    • Author(s)
      田中孝之、平家俊男, 他
    • Organizer
      第21回日本小児リウマチ学会総会・学術集会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2011-10-16
    • Data Source
      KAKENHI-PROJECT-23249056
  • [Presentation] 多能性幹細胞(ES細胞、iPS細胞)を用いた骨格筋幹/前駆細胞の同定およびその臨床応用に関する研究2011

    • Author(s)
      平家俊男、粟屋智就、加藤竹雄
    • Organizer
      平成23年度精神・神経疾患研究開発費「筋ジストロフィーに対するトランスレーショナル・リサーチ」班 班会議
    • Place of Presentation
      JA共済ビル(東京都)
    • Data Source
      KAKENHI-PROJECT-23791170
  • [Presentation] NLRP3体細胞モザイクはCINCA症候群の25%以上に認められる2011

    • Author(s)
      田中尚子、井澤和司、斎藤潤、作間未織、大嶋宏一、小原収、西小森隆太、森本剛、中畑龍俊、平家俊男
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21390310
  • [Presentation] ヒトES/iPS細胞から骨格筋への分化誘導と筋疾患への応用2011

    • Author(s)
      粟屋智就、加藤竹雄、柴田実、中畑龍俊、平家俊男
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      グランドプリンスホテル高輪(東京都)
    • Data Source
      KAKENHI-PROJECT-23791170
  • [Presentation] Neutrophil differentiation from human induced pluripotent stem (iPS) cells for disease investigation.2010

    • Author(s)
      Morishima T, Watanabe K, Niwa A, Fujino H, Adachi S, Nakahata T, Heike T
    • Organizer
      The 72^<nd> Annual Metting of the Japanese Society of Hematology
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2010-09-25
    • Data Source
      KAKENHI-PROJECT-20390296
  • [Presentation] Sequential analysis of the alpha and beta-globin gene expressions during erythropoietic differentiation from primate ES cells2007

    • Author(s)
      Umeda K, Heike T, et. al.
    • Organizer
      The 5th anuual meeting of International Society for Stem Cell Research
    • Place of Presentation
      Cairns conventioncenter
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Presentation] 霊長類ES細胞からの造血系細胞の作成2007

    • Author(s)
      平家俊男、篠田現, ほか
    • Organizer
      第49回日本小児血液学会
    • Place of Presentation
      仙台国際センター
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Presentation] Strategy to set up regenerative medicine with safety and efficiency using embryonic stem cells2007

    • Author(s)
      平家俊男
    • Organizer
      第110回日本小児科学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Presentation] ヒト臍帯血CD34陽性細胞は肝障害無しにNOD/SCID/gcnellマウスの肝臓内で肝細胞へと発育する2006

    • Author(s)
      藤野寿典、平家俊男, ほか
    • Organizer
      第68回日本血液学会総会 第48回日本臨床血液学会合同総会
    • Place of Presentation
      福岡国際会議場
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Presentation] Purification of satellite cells from mouse ES cells2006

    • Author(s)
      Chang H, Heike T, et. al.
    • Organizer
      The 4th anuual meeting of International Society for Stem Cell Research
    • Place of Presentation
      Metro Tronto Conventioncenter
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Presentation] 霊長類ES細胞からの選択的分化誘導した赤血球の性状解析2006

    • Author(s)
      梅田雄嗣、平家俊男, ほか
    • Organizer
      第68回日本血液学会総会 第48回日本臨床血液学会合同総会
    • Place of Presentation
      福岡国際会議場
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Presentation] The mechanism of cardiac functional improvement aftermultipotent germline stem cells transplantation to AMI model mice2006

    • Author(s)
      Baba S, Heike T, et. al.
    • Organizer
      The 4th anuual meeting of International Society for Stem Cell Research
    • Place of Presentation
      Metro Tronto Conventioncenter
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18390298
  • [Presentation] アナキンラをもちいて治療をおこなった高IgD症候群の2例

    • Author(s)
      下寺佐栄子、西小森隆太、吉岡耕平、河合朋樹、八角高裕、平家俊男
    • Organizer
      第24回小児リウマチ学会
    • Place of Presentation
      仙台
    • Year and Date
      2014-10-03 – 2014-10-05
    • Data Source
      KAKENHI-PROJECT-24390263
  • [Presentation] インフラマソーム

    • Author(s)
      西小森隆太、中川権史、横山宏司、平家俊男
    • Organizer
      第43回日本臨床免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24390263
  • [Presentation] 罹患者由来iPS細胞を用いたCINCA症候群における関節病態の解明

    • Author(s)
      横山宏司、西小森隆太、納富誠司郞、田中孝之、斎藤潤、梅田雄嗣、池谷真、中畑龍俊、戸口田淳也、平家俊男
    • Organizer
      第117回日本小児科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-04-11 – 2014-04-13
    • Data Source
      KAKENHI-PROJECT-24390263
  • [Presentation] 次世代シーケンサーを用いた“変異陰性TRAPS”における体細胞モザイクの検索

    • Author(s)
      19.中川権史、西小森隆太、河合朋樹、八角高裕、平家俊男
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-04-11 – 2014-04-13
    • Data Source
      KAKENHI-PROJECT-26253062
  • [Presentation] 次世代シークエンサーを用いた“変異陰性TRAPS”における体細胞モザイクの検索

    • Author(s)
      中川権史、西小森隆太、河合朋樹、八角高裕、平家俊男
    • Organizer
      第117回日本小児科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-04-11 – 2014-04-13
    • Data Source
      KAKENHI-PROJECT-24390263
  • [Presentation] 羅患者由来iPS細胞を用いたCINCA症候群における関節病態の解明

    • Author(s)
      13.横山宏司、西小森隆太、納富誠司郎、田中孝之、斉藤 潤、梅田雄嗣、池谷 真、中畑龍俊、戸口田淳也、平家俊男
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-04-11 – 2014-04-13
    • Data Source
      KAKENHI-PROJECT-26253062
  • [Presentation] エクソンスキッピングに伴い非典型的な表現型を呈したFilaminA異常症の兄弟例

    • Author(s)
      小田紘嗣、河合朋樹、中川権史、日衛嶋栄太郎、井澤和司、西小森隆太、小原收、沼部博直、平家俊男
    • Organizer
      第117回日本小児科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-04-11 – 2014-04-13
    • Data Source
      KAKENHI-PROJECT-24390263
  • [Presentation] 当科におけるFHL(家族性血球貪食性リンパ組織球症)スクリーニングの現状

    • Author(s)
      堀雅之、八角高裕、西小森隆太、平家俊男
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2014-04-11 – 2014-04-13
    • Data Source
      KAKENHI-PROJECT-26461582
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    # of Collaborated Projects: 9 results
    # of Collaborated Products: 52 results
  • 2.  YASUMI Takahiro (00511891)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 25 results
  • 3.  UMEDA Katsutsugu (80397538)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 29 results
  • 4.  OHARA Osamu (20370926)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 23 results
  • 5.  NISHINAKAMURA Ryuichi (70291309)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 6.  YORIFUJI Tohru (60220779)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
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    # of Collaborated Products: 40 results
  • 8.  SAITOH Megumu (90535486)
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    # of Collaborated Products: 11 results
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    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
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  • 12.  KOIDE Hiroshi (70260536)
    # of Collaborated Projects: 2 results
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  • 13.  ADACHI Soichi (10273450)
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    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
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    # of Collaborated Projects: 2 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  KATO Takeo (60422945)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 19.  FUJINO Hisanori (70532604)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 20.  KAMBE Naotomo (50335254)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 21.  WATANABE Kenichiro (20324634)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 22.  TOGUCHIDA Junya (40273502)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 26.  MISHIMA MICHIAKI (60190625)
    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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  • 30.  HIRAI Toyohiro (20359805)
    # of Collaborated Projects: 1 results
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  • 31.  ITO Isao (40447975)
    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 36.  IZAWA Kazushi (90634931)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 37.  MIKAWA Haruki (00026866)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  AKIYAMA Yuichi (60175809)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  FUJITA Takashi (10156870)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 40.  KATO Hiroki (10597173)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 41.  Ikeda Hanako (20372162)
    # of Collaborated Projects: 1 results
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  • 42.  HATA Masayuki (70748269)
    # of Collaborated Projects: 1 results
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  • 43.  KAKIZUKA Akira (80204329)
    # of Collaborated Projects: 1 results
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  • 44.  服部 春生 (80189571)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  河井 昌彦 (00283599)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  星野 勇馬 (00378746)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  新実 彰男 (30252513)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  河合 朋樹 (20631568)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 49.  林 英蔚 (40283600)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  TANAKA Takayuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 51.  NAKAGAWA Kenji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 52.  HONDA Yoshitaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 53.  OHTO Taisuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 54.  ODA Hirotsugu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 55.  HORI Masayuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 56.  HIEJIMA Eitaro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 57.  SHIBATA Hirofumi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 58.  OSHIMA Koichi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 59.  NIWA Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 60.  IKEYA Makoto
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 61.  戸田口 淳也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 7 results

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