Higami Yoshikazu 樋上賀一

… Alternative Names

HIGAMI Yoshikazu 樋上賀一

樋上賀一ヒガミヨシカズ

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Researcher Number	90253640
Other IDs
External Links
Affiliation (Current)	2025: 東京理科大学, 薬学部生命創薬科学科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2025: 東京理科大学, 薬学部生命創薬科学科, 教授 2013 – 2015: 東京理科大学, 薬学部, 教授 2010 – 2011: 東京理科大学, 薬学部, 教授 2007 – 2008: Tokyo University of Science, 薬学部, 教授 2004 – 2005: 長崎大学, 大学院・医歯薬学総合研究科, 助教授 … More 2000 – 2001: 長崎大学, 医学部, 助教授 1998 – 1999: 長崎大学, 医学部, 講師 1994 – 1996: 長崎大学, 医学部, 講師 1993: 長崎大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Experimental pathology / Experimental pathology / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 59040:Nutrition science and health science-related / Applied health science Except Principal Investigator Basic Section 59040:Nutrition science and health science-related / Respiratory surgery / Thoracic surgery / Experimental pathology / Basic Section 90120:Biomaterials-related … More / Basic Section 42020:Veterinary medical science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Experimental pathology / Neuroscience in general / Environmental physiology (including Physical medicine and Nutritional physiology) / 老化(加齢) Less
Keywords	Principal Investigator カロリー制限 / 老化 / 脂肪組織 / IGF-1 / ミトコンドリア / DNA chip / 白色脂肪組織 / 脂質代謝 / DNA array / トランスジェニックラット … More / ミトファジー / ミトコンドリアシグナルペプチダーゼ / Mipep / 肥満症 / 脂肪細胞 / ノックアウトマウス / SREBP1 / 寿命 / 食餌制限 / 肝細胞 / ミトコンドリアUPR / RNA-seq / マウス / サル / レスベラトロール / GDF15 / ミトコンドリアストレス応答 / ミトコンドリ生合成 / 脂肪酸生合成 / 脂肪萎縮 / 食餌誘導性肥満 / リポジストロフィー / エネルギー代謝 / MIPEP / リポディストロフィー / スプライシング制御 / スプライシング / 体内時計 / リソソーム / PARIS / ミトコンドリア生合成 / SREBP-1 / adipocytokine / white adipose tissue / insulin sensitivity / transgenic rats / growth hormone / calorie restriction / アディポネクチン / アディポサイトカイン / インシュリン感受性 / 成長ホルモン / liver / lipid metabolism / transgenic rat / Forkhead transcription factor / growth hormonef(GH)IGF-1 / calorie restriction(CR) / aging / 肝臓 / Forkhead転写因子 / GH / 食餌カロリー制限 / 寿命延長 / PINK1/PARKIN / SIRT3 / ミトコンドリア品質管理 / ミトコンドリア病 / ミトコンドリアシグナルペプチターゼ / ミトコンドリアの品質管理 / Srebp-1c / 白色脂肪組織（WAT） / カロリーの制限（CR） / Sirt3 / シグナルペプチダーゼ / 品質管理 / ユビキチンリガーゼ / WWP1 / p53 / 炎症 / 細胞傷害 / LXR / SREBPI / DNase γ / Fas ligand / DNaseγ / セラミド / Fas / アポトーシス / TUNEL / PCNA / サイクロヘキシミド / 細胞死 / 細胞増殖 / 職餌制限 … More Except Principal Investigator 老化 / 肺移植 / カロリー制限 / ミトコンドリア / 機能疲弊 / 分化転換 / 膵島 / 2型糖尿病 / 再生医療 / Aging / マトリックス / 再細胞化 / 脱細胞化 / 組織工学 / 再生 / 肺 / 肺再生 / ラット / ミトコンドリアシグナルペプチダーゼ / ミトコンドリア導入技術 / 細胞医薬 / 間葉系幹細胞 / 内臓脂肪炎症 / 免疫記憶 / 胎生期環境 / 炎症 / 内臓脂肪 / 胎児期 / 胎生期 / DOHAD / 免疫 / 自然抗体 / B細胞 / 免疫系 / 早期ライフステージ / 腸肝連関 / 食餌誘導性肝がん / IGF1 / FGF21 / CREBH / 成長ホルモン抵抗性 / 栄養吸収 / 腸内細菌叢 / 肝臓がん / 脂肪肝 / 腸内細菌 / 肝がん / 脂質代謝 / 生活習慣病 / 白色脂肪組織 / マイトファジー / ミトコンドリア生合成 / ブタ / 気管 / 移植・再生医療 / 移植 / 細胞外マトリックス / 気管移植 / 移植免疫 / 組織骨格 / 異種移植 / 臓器移植 / 気管再生 / Energy metabolism / Stress response / Insulin-like growth factor / Growth hormone / Insulin / Calorie-restriction / Longevity / エネルギー代謝 / ストレス応答 / インスリン様成長因子 / 成長ホルモン / インスリン / 長寿 / Neuroendocrine / Leptin / Caloric restriction / 神経内分泌 / レプチン / バイオリアクター / 脂肪肝細胞 / PARP阻害剤 / ラット肺移植 / 肺虚血再灌流 / PARP inhibitor / 脂肪幹細胞 / 虚血再灌流障害 / マイクロアレイ / 肺癌 / 肺気腫 / 小胞体ストレス / リポポリサッカライド / アディポネクチン / Neuropeptide Y / TGF / bFGF / IGF-1 / 成長因子 / 下垂体 / カロリー / 食餌制限 / 形態学的解析 / アセチルコリン・エステラーゼ / HNK-1 / 刺激伝導異常 / 未熟心 / 先天性心疾患 Less

新規老化制御機構の確立を志向した生体内ミトコンドリアタンパク質成熟プロセスの検証
- Principal Investigator
  
  小林正樹
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Ochanomizu University
ミトカインGDF15による末梢組織での直接的な新規代謝改善・抗炎症作用機構の解明Principal Investigator
- Principal Investigator
  
  樋上賀一
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Tokyo University of Science
Development of innovative MSC-based therapy based on intracellular mitochondrial delivery methods
- Principal Investigator
  
  草森浩輔
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Tokyo University of Science
膵β細胞における機能疲弊と分化転換の可塑性・可逆性が織りなす糖尿病病態の多様性
- Principal Investigator
  
  沖田直之
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science, Yamaguchi
ミトコンドリア生合成/分解の調節因子PARISを中心とした代謝病態機構の解明
- Principal Investigator
  
  小林正樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science
Elucidation of the mechanism of liver cancer induced by abnormal lipid metabolism in enterohepatic association
- Principal Investigator
  
  中川嘉
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  University of Toyama
Chronological impact of fetal immune memory on visceral adipose tissue inflammation
- Principal Investigator
  
  Goitsuka Ryo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Tokyo University of Science
Reguratory mechanisms of lifespan by altered energy metabolism via splicing controlPrincipal Investigator
- Principal Investigator
  
  Higami Yoshikazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science
Investigative research on the extention of healthy lifespan that can be applied to humans based on mitochondrial unfolded protein responsePrincipal Investigator
- Principal Investigator
  
  Higami Yoshikazu
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Tokyo University of Science
Molecular basis of transdifferentiation mechanism in type 2 diabetes mellitus ~for establishment of personalized therapy for type 2 diabetes~
- Principal Investigator
  
  OKITA Naoyuki
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science, Yamaguchi
Dysregulation of lysosome/mitochondrial interaction in obese adipose tissuePrincipal Investigator
- Principal Investigator
  
  Higami Yoshikazu
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo University of Science
Transplantation studies of tissue engineered tracha and lung regenerated from recellularized xenogeneic-decellularized scaffold
- Principal Investigator
  
  TSUCHIYA Tomoshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Nagasaki University
Comprehensive mitochondrial quality control and its collapse in metabolic diseasesPrincipal Investigator
- Principal Investigator
  
  Higami Yoshikazu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo University of Science
Basic researches for the improvement of the fragility and the organ portection about de-and re-cellularization based regenerated lung
- Principal Investigator
  
  TSUCHIYA Tomoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory surgery
- Research Institution
  Nagasaki University
The study of tissue protection and cell implantation effects by adipose tissue derived stromal cells for future usage in damaged or transplanted lung
- Principal Investigator
  
  TSUCHIYA Tomoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Nagasaki University
Functional Analysis of a Novel Obesity-associated E3 Ubiquitin Ligase WWP1Principal Investigator
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo University of Science
The effects of adiponectin on lung cancer and lung disease
- Principal Investigator
  
  TSUCHIYA Tomoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Nagasaki University
Mechanisms underlying the effect of calorie restriction : Analyses of neuropeptide Y and receptor subtypes
- Principal Investigator
  
  SHIMOKAWA Isao
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Nagasaki University
Suppressed cellular damage and inflammation, and altered metabolism by caloric restriction via SREBP1/LXRPrincipal Investigator
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo University of Science
Investigation of genes involved in anti-obesity and insulin sensitivity in the white adipose tissuePrincipal Investigator
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
Regulation of aging in mammals : Difference between the effects of calorie restriction and suppression of the GH-IGF-1 axis
- Principal Investigator
  
  SHIMOAKAWA Isao
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University Graduate School of Biomedical Sciences
What is the target of anti-aging action of calorie restriction?Principal Investigator
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University School of Medicine
Mechanisms underlying the anti-aging effect of caloric restriction: A role for leptin in regulation of neuroendocrine system
- Principal Investigator
  
  SHIMOKAWA Isao
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  NAGASAKI UNIVERSITY SCHOOL OF MEDICINE
加齢に伴うFas抗原発現を介する肝細胞死増強と食餌制限によるその抑制に関する研究-セラミド、DNaseγの活性化-Principal Investigator
- Principal Investigator
  
  樋上賀一
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
食餌制限による下垂体前葉細胞の加齢、腫瘍化抑制機構-成長因子の関連性について-
- Principal Investigator
  
  下川功
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Nagasaki University
肝細胞の増殖と細胞死の加齢変化および食餌制限の影響に関する細胞生物学的研究Principal Investigator
- Principal Investigator
  
  樋上賀一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
ラット先天性心疾患及び未熟児における刺激伝導異常の解析
- Principal Investigator
  
  池田高良
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
先天性刺激伝導異常の発生病理
- Principal Investigator
  
  池田高良
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University

[Journal Article] Individual evaluation of aging- and caloric restriction-related changes to distinct multimeric complexes of circulating adiponectin by immunoblotting2022
- Author(s)
  Kobayashi Masaki、Nezu Yuichiro、Itoh Mayu、Uchida Rio、Arikawa Tomoya、Otsubo Minami、Nozaki Yuka、Tagawa Ryoma、Fujishima Yuya、Maeda Norikazu、Shimomura Iichiro、Higami Yoshikazu
- Journal Title
  
  Experimental Gerontology
  
  Volume: 164 Pages: 111821-111821
- DOI
  10.1016/j.exger.2022.111821
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-22K17814
[Journal Article] Long-Term Dietary Taurine Lowers Plasma Levels of Cholesterol and Bile Acids2022
- Author(s)
  Tagawa Ryoma、Kobayashi Masaki、Sakurai Misako、Yoshida Maho、Kaneko Hiroki、Mizunoe Yuhei、Nozaki Yuka、Okita Naoyuki、Sudo Yuka、Higami Yoshikazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 3 Pages: 1793-1793
- DOI
  10.3390/ijms23031793
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-22K17814, KAKENHI-PROJECT-20K19686
[Journal Article] Prolonged caloric restriction ameliorates age-related atrophy in slow and fast muscle fibers of rat soleus muscle2021
- Author(s)
  Yuhei Mizunoe, Masaki Kobayashi, Hiroki Saito, Akifumi Goto, Ryota Migitaka, Kumi Miura, Naoyuki Okita, Yuka Sudo, Ryoma Tagawa, Miki Yoshida, Ai Umemori, Yoshimi Nakagawa, Hitoshi Shimano, Yoshikazu Higami
- Journal Title
  
  Experimental gerontology
  
  Volume: 154 Pages: 111519-111519
- DOI
  10.1016/j.exger.2021.111519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19J00407, KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-20K19686
[Journal Article] Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan2021
- Author(s)
  Kobayashi Masaki、Nezu Yuichiro、Tagawa Ryoma、Higami Yoshikazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 6 Pages: 2854-2854
- DOI
  10.3390/ijms22062854
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-20K19686
[Journal Article] Contribution of PGC-1α to Obesity- and Caloric Restriction-Related Physiological Changes in White Adipose Tissue2021
- Author(s)
  Kobayashi Masaki、Deguchi Yusuke、Nozaki Yuka、Higami Yoshikazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 11 Pages: 6025-6025
- DOI
  10.3390/ijms22116025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-20K19686
[Journal Article] Metabolic Alteration in Aging Process: Metabolic Remodeling in White Adipose Tissue by Caloric Restriction2020
- Author(s)
  Kobayashi M, Higami Y.
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 140 Issue: 3 Pages: 383-389
- DOI
  10.1248/yakushi.19-00193-2
- NAID
  130007803984
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2020-03-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Is PARP-1 Inhibitor (Nutlin3a) Effective on Hepatic Ischemia-Reperfusion Injury?2020
- Author(s)
  Kawahara Daisuke、Yamanouchi Kosho、Okita Naoyuki、Higami Yoshikazu、Inoue Yusuke、Ito Shinichiro、Hidaka Masaaki、Kanetaka Kengo、Fujita Fumihiko、Eguchi Susumu
- Journal Title
  
  Surgery, Gastroenterology and Oncology
  
  Volume: 25 Issue: 4 Pages: 189-189
- DOI
  10.21614/sgo-25-4-189
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11119
[Journal Article] Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes2020
- Author(s)
  Kobayashi Masaki、Yasukawa Hiromine、Arikawa Tomoya、Deguchi Yusuke、Mizushima Natsumi、Sakurai Misako、Onishi Shoichi、Tagawa Ryoma、Sudo Yuka、Okita Naoyuki、Higashi Kyohei、Higami Yoshikazu
- Journal Title
  
  FEBS Open Bio
  
  Volume: 11 Issue: 1 Pages: 185-194
- DOI
  10.1002/2211-5463.13055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20KK0228, KAKENHI-PROJECT-20K19686
[Journal Article] WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism2020
- Author(s)
  Hoshino Shunsuke、Kobayashi Masaki、Tagawa Ryoma、Konno Ryutaro、Abe Takuro、Furuya Kazuhiro、Miura Kumi、Wakasawa Hiroki、Okita Naoyuki、Sudo Yuka、Mizunoe Yuhei、Nakagawa Yoshimi、Nakamura Takeshi、Kawabe Hiroshi、Higami Yoshikazu
- Journal Title
  
  FEBS Open Bio
  
  Volume: 10 Issue: 3 Pages: 306-315
- DOI
  10.1002/2211-5463.12795
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17H02179
[Journal Article] Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes2020
- Author(s)
  Mizunoe Yuhei、Kobayashi Masaki、Hoshino Shunsuke、Tagawa Ryoma、Itagawa Rei、Hoshino Ayana、Okita Naoyuki、Sudo Yuka、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 634-634
- DOI
  10.1038/s41598-020-57428-6
- NAID
  120007165462
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-18K17953, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-17H02179
[Journal Article] Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line2020
- Author(s)
  Kobayashi Masaki、Ishizaki Yuka、Owaki Mika、Matsumoto Yoko、Kakiyama Yuri、Hoshino Shunsuke、Tagawa Ryoma、Sudo Yuka、Okita Naoyuki、Akimoto Kazunori、Higami Yoshikazu
- Journal Title
  
  Oncotarget
  
  Volume: 11 Issue: 18 Pages: 1653-1665
- DOI
  10.18632/oncotarget.27581
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-20K07207, KAKENHI-PROJECT-20K19686
[Journal Article] Multidisciplinary Approach to Aging: Future Trends2020
- Author(s)
  Takahashi R, Higami Y.
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 140 Issue: 3 Pages: 377-378
- DOI
  10.1248/yakushi.19-00193-F
- NAID
  130007803982
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2020-03-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative stress in adipocytes2019
- Author(s)
  Kobayashi Masaki、Hoshino Shunsuke、Abe Takuro、Okita Naoyuki、Tagawa Ryoma、Nagai Wataru、Konno Ryutaro、Suzuki Yuki、Furuya Kazuhiro、Ishikawa Natsumi、Okado Hitoshi、Oku Misako、Iwamoto Machiko、Miura Yuri、Sudo Yuka、Higami Yoshikazu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 508 Issue: 1 Pages: 117-122
- DOI
  10.1016/j.bbrc.2018.11.127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-17H02179
[Journal Article] Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue.2019
- Author(s)
  Namiki Fujii, Seira Uta, Masaki Kobayashi, Tsugumichi Sato, Naoyuki Okita, Yoshikazu Higami
- Journal Title
  
  Experimental gerontology
  
  Volume: 118 Pages: 55-64
- DOI
  10.1016/j.exger.2019.01.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17H02179
[Journal Article] Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome2019
- Author(s)
  Mizunoe Yuhei、Kobayashi Masaki、Tagawa Ryoma、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 15 Pages: 3688-3688
- DOI
  10.3390/ijms20153688
- NAID
  120007133171
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-18K17953, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051, KAKENHI-PROJECT-17H02179
[Journal Article] Trehalose protects against oxidative stress by regulating the Keap1-Nrf2 and autophagy pathways2018
- Author(s)
  Mizunoe Yuhei、Kobayashi Masaki、Sudo Yuka、Watanabe Shukoh、Yasukawa Hiromine、Natori Daiki、Hoshino Ayana、Negishi Arisa、Okita Naoyuki、Komatsu Masaaki、Higami Yoshikazu
- Journal Title
  
  Redox Biol.
  
  Volume: 15 Pages: 115-124
- DOI
  10.1016/j.redox.2017.09.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-17H02179
[Journal Article] Mechanisms of the anti-aging and prolongevity effects of caloric restriction: evidence from studies of genetically modified animals.2018
- Author(s)
  Hoshino S, Kobayashi M, Higami Y
- Journal Title
  
  Aging (Albany NY)
  
  Volume: 10 Issue: 9 Pages: 2243-2251
- DOI
  10.18632/aging.101557
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia2018
- Author(s)
  Sudo Yuka、Otsuka Hiroki、Miyakawa Ryota、Goto Akifumi、Kashiwase Yohei、Terawaki Kiyoshi、Miyano Kanako、Hirao Yuto、Taki Kanari、Tagawa Ryoma、Kobayashi Masaki、Okita Naoyuki、Uezono Yasuhito、Higami Yoshikazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Issue: 12 Pages: 3852-3852
- DOI
  10.3390/ijms19123852
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17H02179
[Journal Article] SREBP-1c-Dependent Metabolic Remodeling of White Adipose Tissue by Caloric Restriction.2018
- Author(s)
  Masaki Kobayashi, Namiki Fujii, Takumi Narita, Yoshikazu Higami
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: - Issue: 11 Pages: 11-11
- DOI
  10.3390/ijms19113335
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-17H02179
[Journal Article] Taurine is an amino acid with the ability to activate autophagy in adipocytes.2018
- Author(s)
  Kaneko H, Kobayashi M, Mizunoe Y, Yoshida M, Yasukawa H, Hoshino S, Itagawa R, Furuichi T, Okita N, Sudo Y, Imae M, Higami Y
- Journal Title
  
  Amino Acids
  
  Volume: 50 Issue: 5 Pages: 527-535
- DOI
  10.1007/s00726-018-2550-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Differential response to caloric restriction of retroperitoneal, epididymal, and subcutaneous adipose tissue depots in rats2018
- Author(s)
  Narita Takumi、Kobayashi Masaki、Itakura Kaho、Itagawa Rei、Kabaya Riho、Sudo Yuka、Okita Naoyuki、Higami Yoshikazu
- Journal Title
  
  Exp Gerontol
  
  Volume: 104 Pages: 127-137
- DOI
  10.1016/j.exger.2018.01.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Modified Western blotting for insulin and other diabetes-associated peptide hormones.2017
- Author(s)
  Okita N, Higami Y, Fukai F, Kobayashi M, Mitarai M, Sekiya T, Sasaki T.
- Journal Title
  
  Sci Rep
  
  Volume: 7:6949 Issue: 1 Pages: 1-11
- DOI
  10.1038/s41598-017-04456-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461346, KAKENHI-PROJECT-17H02179
[Journal Article] A novel caloric restriction mediator2017
- Author(s)
  Kobayashi Masaki、Higami Yoshikazu
- Journal Title
  
  Aging (Albany NY)
  
  Volume: 9 Issue: 10 Pages: 2012-2013
- DOI
  10.18632/aging.101311
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction2017
- Author(s)
  Fujii Namiki、Narita Takumi、Okita Naoyuki、Kobayashi Masaki、Furuta Yurika、Chujo Yoshikazu、Sakai Masahiro、Yamada Atsushi、Takeda Kanae、Konishi Tomokazu、Sudo Yuka、Shimokawa Isao、Higami Yoshikazu
- Journal Title
  
  Aging Cell
  
  Volume: 16 Issue: 3 Pages: 508-517
- DOI
  10.1111/acel.12576
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction2017
- Author(s)
  Kobayashi Masaki、Takeda Kanae、Narita Takumi、Nagai Keita、Okita Naoyuki、Sudo Yuka、Miura Yuri、Tsumoto Hiroki、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
- Journal Title
  
  FEBS Lett.
  
  Volume: 591 Issue: 24 Pages: 4067-4073
- DOI
  10.1002/1873-3468.12914
- NAID
  120007134579
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01811, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-17H02179
[Journal Article] Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice2017
- Author(s)
  Mizunoe Yuhei、Sudo Yuka、Okita Naoyuki、Hiraoka Hidenori、Mikami Kentaro、Narahara Tomohiro、Negishi Arisa、Yoshida Miki、Higashibata Rikako、Watanabe Shukoh、Kaneko Hiroki、Natori Daiki、Furuichi Takuma、Yasukawa Hiromine、Kobayashi Masaki、Higami Yoshikazu
- Journal Title
  
  Autophagy
  
  Volume: 13 Issue: 4 Pages: 642-653
- DOI
  10.1080/15548627.2016.1274850
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Poly(ADP-ribose) Polymerase Inhibitor (PJ34) Reduces Pulmonary Ischemia-Reperfusion Injury in Rats2014
- Author(s)
  Go Hatachi, Tomoshi Tsuchiya, Takuro Miyazaki, Keitaro Matsumoto, Naoya Yamasaki, Shingo Matsushima, Atsushi Nanashima, Yoshikazu Higami, and Takeshi Nagayasu
- Journal Title
  
  Transplantation
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592066
[Journal Article] Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain : implications for longevity2009
- Author(s)
  Chiba T, Inoue D, Mizuno A, Komatsu T, Fujita S, Kubota H, Luisa Tagliaro M, Park S, Trindade LS, Hayashida T, Hayashi H, Yamaza H, Higami Y, himokawa I
- Journal Title
  
  Neurobiol Aging 27
  
  Pages: 474-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-ccelerated mouse strain P82008
- Author(s)
  Komatsu T, Chiba T, Yamaza H, Yamashita K, Shimada A, Hoshiyama Y, Henmi T, Ohtani H, Higami Y, de Cabo R, Ingram DK, Shimokawa I
- Journal Title
  
  Exp Gerontol 43(4)
  
  Pages: 339-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Calorie restriction minimizes activation of insulin signaling in response to glucose : potential involvement of the growth hormone-insulin-like growth factor 1 axis2008
- Author(s)
  Hayashi H, Yamaza H, Komatsu T, Park S, Chiba T, Higami Y, Nagayasu T, Shimokawa I
- Journal Title
  
  Exp Gerontol 43(9)
  
  Pages: 827-32
- NAID
  120006981679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Genet ic suppression of GH-IGF-1 activity, combined with lifelong caloric restri-ction, prevents age-related renal damage and prolongs the life span in rats2008
- Author(s)
  Zha Y, Taguchi T, Nazneen A, Shimokawa I, Higami Y, Razzaque MS
- Journal Title
  
  Am J Nephrol 28(5)
  
  Pages: 755-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness : relationship with caloric restriction2008
- Author(s)
  Chiba T, Yamaza H, Komatsu T, Nakayama M, Fujita S, Hayashi H, Higami Y, Shimokawa I
- Journal Title
  
  Exp Gerontol 43(6)
  
  Pages: 595-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Identification of fasting-induced genes in the rat hypothalamus : relationship with neuroprotection2007
- Author(s)
  Chiba T, Fujita S, Kubota H, Inoue D, Mizuno A, Komatsu T, Yamaza H, Higami Y, Shimokawa I
- Journal Title
  
  Ann N Y Acad Sci. 1119
  
  Pages: 216-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver2007
- Author(s)
  To K, Yamaza H, Komatsu T, Hayashida T, Hayashi H, Toyama H, Chiba T, Higami Y, Shimokawa I
- Journal Title
  
  Exp Gerontol 42(11)
  
  Pages: 1063-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Involvement of insulin-like growth factor-1 in the effect of caloric restriction : regulation of plasma adiponectin and leptin2007
- Author(s)
  Yamaza H, Komatsu T, To K, Toyama H, Chiba T, Higami Y, Shimokawa I
- Journal Title
  
  J Gerontol A Biol Sci Med Sci. 62(1)
  
  Pages: 27-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.2006
- Author(s)
  Higami Y, Barger JL, et al.
- Journal Title
  
  J Nutr. 136・2
  
  Pages: 343-52
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Gene expression profile of caloric restriction in mouse adipose tissue : Lowered expression of genes linked to inflammation, cytoskeleton, extracellular matrix and angiogenesis2006
- Author(s)
  Higami Y, Barger JL, Page GP, Allison DB, Chen L, Smith SR, Prolla TA, Weindruch R.
- Journal Title
  
  J Nutr 136
  
  Pages: 343-352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Gene expression profile of caloric restriction in mouse adipose tissue : Lowered expression of genes linked to inflammation, cytoskeleton, extracellular matrix and angiogenesis2006
- Author(s)
  Higami Y
- Journal Title
  
  J Nutrition 136
  
  Pages: 343-352
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Role of leptin signaling in the hypothalamus in the effect of calorie restriction2006
- Author(s)
  Komatsu T, Chiba T, Yamaza H, To K, Toyama H, Higami Y, Shimokawa I.
- Journal Title
  
  J Gerontol : Bio Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.2006
- Author(s)
  Higami Y, Barger JL, Page GP, Allison DB, Smith SR, Prolla TA, Weindruch R
- Journal Title
  
  J Nutr 136
  
  Pages: 343-352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005
- Author(s)
  Higami Y, Yamaza H, Shimokawa I.
- Journal Title
  
  Adv Clin Chem. 39
  
  Pages: 211-237
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-Induced inflammation2005
- Author(s)
  Tsuchiya T, Higami Y, Komatsu T, Tanaka K, Honda S, Yamaza H, Chiba T, Ayabe H, Shimokawa I.
- Journal Title
  
  Mech Ageing and Develop 126
  
  Pages: 568-579
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation.2005
- Author(s)
  Tsuchiya T, Higami Y, Komatsu T, Tanaka K, Honda S, Yamaza H, Chiba T, Ayabe H, Shimokawa I
- Journal Title
  
  Mech Ageing Dev 126
  
  Pages: 568-579
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation2005
- Author(s)
  Tsuchiya T, Higami Y, et al.
- Journal Title
  
  Mech Ageing Dev. 126・5
  
  Pages: 568-79
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005
- Author(s)
  Higami Y, Yamaza H, Shinozawa I.
- Journal Title
  
  Adv Clin Chem. 39
  
  Pages: 211-37
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Glucose metabolism in calorie-restricted or transgenic dwarf rat : Analysis of adiponectin-AMPK pathway (in Japanese)2005
- Author(s)
  Hayashi H, Yamaza H, Tou K, Toyama H, Komatsu T, Chiba T, Higami Y, Shimokawa I.
- Journal Title
  
  Biomedical Gerontology 29
  
  Pages: 31-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Laboratory findings of caloric restriction in rodents and primates2005
- Author(s)
  Higami Y
- Journal Title
  
  Adv Clin Chem 39
  
  Pages: 211-237
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Laboratory findings of caloric restriction in rodents and primates2005
- Author(s)
  Higami Y 他
- Journal Title
  
  Adv Clin Chem 39
  
  Pages: 211-237
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation.2005
- Author(s)
  Tsuchiya T, Higami Y, et al.
- Journal Title
  
  Mech Ageing Dev. 126・5
  
  Pages: 568-579
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Laboratory findings of caloric restriction in rodents and primates2005
- Author(s)
  Higami Y, Yamaza H, Shimokawa I.
- Journal Title
  
  Adv Clin Chem 39
  
  Pages: 211-237
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Glucose-insulin system in long-lived rats ; effects of calorie restriction and suppression of GH-IGF-1 axis (in Japanese)2005
- Author(s)
  Yamaza H, Komatsu T, Higami Y, Shimokawa I.
- Journal Title
  
  Biomedical Gerontology
  
  Pages: 25-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005
- Author(s)
  Higami Y, Shimokawa I, Yamaza H
- Journal Title
  
  Adv Clin Chem 39
  
  Pages: 211-237
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Altered energy metabolism in anti-aging and lifespan extension by caloric restriction (in Japanese)2004
- Author(s)
  Higami Y.
- Journal Title
  
  Biomedical Gerontology 28
  
  Pages: 15-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Altered lipid metabolism in rodents animals subjected to caloric restriction2004
- Author(s)
  Higami Y, Weindruch R, Prolla TA, Shimokawa I
- Journal Title
  
  Geriatrics Gerontol Int, 4
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] A transgenic dwarf rat model as a tool for the study of calorie restriction and aging.2004
- Author(s)
  Yamaza H, Komatsu T, Chiba T, Toyama H, To K, Higami Y, Shimokawa I.
- Journal Title
  
  Exp Gerontol 39
  
  Pages: 269-272
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes2004
- Author(s)
  Higami Y, Tsuchiya T, To K, Chiba T, Yamaza H, Shiokawa D, Tanuma S, Shimokawa I.
- Journal Title
  
  Cell Tissue Res, 316
  
  Pages: 403-407
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Altered lipid metabolism in rodents animals subjected to caloric restriction2004
- Author(s)
  Higami Y
- Journal Title
  
  Geriatrics Gerontology International 4
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Aging increases DNase γ, an apoptosis-related endonuclease, in rat liver nuclei : effect of dietary restriction.2004
- Author(s)
  Tanaka K, Higami Y, Tsuchiya T, Shiokawa D1, Tanuma S1, Ayabe H2, Shimokawa I.
- Journal Title
  
  Exp Gerontol 39
  
  Pages: 195-202
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes2004
- Author(s)
  Higami Y
- Journal Title
  
  Cell Tissue Res 316
  
  Pages: 403-407
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes2004
- Author(s)
  Higami Y 他
- Journal Title
  
  Cell Tissue Res 316
  
  Pages: 403-407
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] カロリー制限による抗老化・寿命延長作用 -代謝の変化から見たそのメカニズム-2004
- Author(s)
  樋上賀一
- Journal Title
  
  基礎老化研究 28
  
  Pages: 15-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Gene expression analysis of calorie restriction by DNA microarray (in Japanese)2004
- Author(s)
  Kayo T, Higami Y, Weindruch R.
- Journal Title
  
  Experimental Medicine 2
  
  Pages: 837-841
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Effects of caloric restriction on gene expression in the arcuate nucleus.2003
- Author(s)
  Shimokawa I, Fukuyama T, Yanagihara-Outa K, Tomita M, Komatsu T, Higami Y, Tsuchiya T, Chiba T, Yamaza H.
- Journal Title
  
  Neurobiol Aging, 24
  
  Pages: 117-123
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis : relation to caloric restriction.2003
- Author(s)
  Shimokawa I, Higami Y, Tsuchiya T, Otani H, Komatsu T, Chiba T, Yamaza H.
- Journal Title
  
  FASEB J, 17
  
  Pages: 1108-1109
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Hepatic gene expression profile of lipid metabolism in rats : impact of caloric restriction and growth hormone/IGF-1 suppression.
- Author(s)
  Higami Y, Tsuchiya T, Chiba T, Yamaza H, Muraoka I, Hirose M, Komatsu T, Shimokawa I
- Journal Title
  
  J Gerontol A Biol Sci Med Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Effect of leptin on hypothalamic gene expression in calorie-restricted rats.
- Author(s)
  Komatsu T, Chiba T, Yamaza H, To K, Toyama H, Higami Y, Isao Shimokawa I
- Journal Title
  
  J Gerontol A Biol Sci Med Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Hepatic gene expression profile of lipid metabolism in rats : impact of caloric restriction and growth hormone/IGF-1 suppression.
- Author(s)
  Higami Y, Tsuchiya T, et al.
- Journal Title
  
  J Gerontol A Biol Sci Med Sci in press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Effect of leptin on hypothalamic gene expression in calorie-restricted rats.
- Author(s)
  Komatsu T, Higami Y, et al.
- Journal Title
  
  J Gerontol A Biol Sci Med Sci in press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Patent] 抗肥満物質のスクリーニング方法及び抗肥満物質のスクリーニング用キット2018
- Inventor(s)
  樋上賀一、小林正樹、成田匠、瀧加菜里
- Industrial Property Rights Holder
  樋上賀一、小林正樹、成田匠、瀧加菜里
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-133627
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17H02179
[Patent] 寿命延長関連遺伝子およびその用途2007
- Inventor(s)
  千葉卓哉、下川功、樋上賀一、山座治義
- Industrial Property Rights Holder
  国立大学法人長崎大学
- Industrial Property Number
  2007-061075
- Filing Date
  2007-03-07
- Data Source
  KAKENHI-PROJECT-19590227
[Presentation] 静脈内に投与したミトコンドリアの体内動態評価2024
- Author(s)
  金井舞、草森浩輔、板倉祥子、小林正樹、樋上賀一、西川元也
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K28437
[Presentation] 細胞内へのミトコンドリア導入による神経細胞の機能向上2023
- Author(s)
  近藤百萌、草森浩輔、板倉祥子、小林正樹、樋上賀一、西川元也
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-23K28437
[Presentation] 異なる種類のドナー細胞から単離したミトコンドリアの体内動態評価2023
- Author(s)
  金井舞、草森浩輔、小林正樹、樋上賀一、西川元也
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-23K28437
[Presentation] A Novel Molecular Mechanism of Metabolic Remodeling, Anti-aging and Pro-longevity Actions of Caloric Restriction2019
- Author(s)
  Higami Y, Kobayashi M, Tagawa R
- Organizer
  第42回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] カロリー制限による脂肪細胞におけるミトコンドリア機能亢進メカニズムの解析2019
- Author(s)
  内田理緒、瀧加菜里、小林正樹、樋上賀一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 栄養とサルコペニア　～長期カロリー制限モデルからの知見を基にした考察～2019
- Author(s)
  樋上賀一
- Organizer
  第31回日本老年学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Western blottingのプロトコール改変による低分子量ペプチドの分離検出-糖尿病関連ペプチドホルモンを実施例として-2019
- Author(s)
  沖田直之、樋上賀一、深井文雄、小林正樹、御手洗光来、関谷剛男、佐々木敬
- Organizer
  第60回日本生化学会中四国支部大会
- Data Source
  KAKENHI-PROJECT-18K11119
[Presentation] カロリー制限による脂肪細胞組織での代謝リモデリング2019
- Author(s)
  樋上賀一
- Organizer
  日本薬学会第139年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 肥満症脂肪組織における新規肥満応答因子WWP1の機能解析2019
- Author(s)
  若澤広樹、星野駿介、古屋和寛、三浦久実、小林正樹、樋上賀一
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] タウリンの生体内恒常性維持機構の解析2018
- Author(s)
  吉田眞帆、小林正樹、井前正人、樋上賀一
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] A novel mediator for pro-longevity and anti-aging actions of caloric restriction2018
- Author(s)
  Masaki Kobayashi, Yoshikazu Higami
- Organizer
  Asian Society for Aging Research Symposium 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 抗老化・寿命延伸作用を示すカロリー制限による脂肪組織リモデリングにおける新規メディエーター2018
- Author(s)
  樋上賀一、小林正樹
- Organizer
  第39回日本肥満学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Functional analysis of E3 ubiquitin ligase Wwp1 in mouse white adipose tissue2018
- Author(s)
  Shunsuke HOSHINO, Msaki KOBAYASI, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The effect of decreasing activity of cathepsin L on adipocytes2018
- Author(s)
  Misako SAKURAI, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The mechanisms of lysosomal dysfunction in white adipose tissue of short-term high-fat diet model2018
- Author(s)
  Natsumi MIZUSHIMA, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] A novel mitochondoria activation mechanism in adipocytes by caloric restriction2018
- Author(s)
  Knari TAKI, Masaki KOBAYASI, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 肥満マウス脂肪組織における新規肥満応答因子Wwp1の機能解析2018
- Author(s)
  星野駿介、小林正樹、樋上賀一
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Influence of WWP1 on antioxidant function in obese adipose tissue2018
- Author(s)
  Kazuhiro FURUYA, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Novel mediators for caloric restriction -associated metabolic remodeling in white adipose tissue2018
- Author(s)
  Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Tarurin is an amino acid with the ability to activate autophagy in adipocytes2018
- Author(s)
  Masaki KOBAYASHI, Hiroki KANEKO, Yuhei MIZUNOE, Maho YOSHIDA, Masato IMAE, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Transcriptional regulation of Fgf21 and Pgc-1 α by caloric restriction2018
- Author(s)
  Seira UTA, Namiki FUJII, Masaki KOBAYASH, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Effects of aging and caloric restriction in Wwp1 expression in skletal muscle2018
- Author(s)
  Kumi MIURA, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Analysis of pharmacological relationship between a Japanese Kanpo Kamikihito on oxytocin receptors2018
- Author(s)
  Yuki YOSHIDA, Kanako MIYANO, Yuji OMIYA, Yoshikazu HIGAMI, Yasuhito UEZONO
- Organizer
  第41回日本基礎老化学会・第9回東京理科大学総合研究院トランスレーショナルリサーチセンターシンポジウム
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] リソソーム機能異常が脂肪滴局在タンパク質ペリリピンに及ぼす影響の解析2018
- Author(s)
  水之江雄平、樋上賀一、小林正樹、星野駿介、中川　嘉、島野　仁
- Organizer
  第39回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 短期高脂肪食摂餌モデルの脂肪組織におけるリソソーム機能破綻メカニズムの解析2018
- Author(s)
  古市拓真、水之江雄平、小林正樹、樋上賀一
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Development of an Obesity Pathology affected by Lysosomal Dysfunction2017
- Author(s)
  Rei ITAGAWA, Yuhei MIZUNOE, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第40回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The Obese Pathology Affected by Lysosomal Dysfunction2017
- Author(s)
  Rei Itagawa, Yuhei Mizunoe, Masaki Kobayashi, Yoshikazu Higami
- Organizer
  第１７回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The role mitochondrial intermediate peptidase (MIPEP) in improvement of mitochondrial metabolism by Caloric Restriction2017
- Author(s)
  Keita NAGAI, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第40回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 皮下脂肪と内臓脂肪におけるカロリー制限への応答の相違2017
- Author(s)
  成田匠、小林正樹、須藤結香、沖田直之、樋上賀一
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 肥満症脂肪組織における新規肥満応答因子Ｗｗｐ１の機能解析2017
- Author(s)
  星野駿介、小林正樹、樋上賀一
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The role of MIPEP in improvement of metabolism by CR2017
- Author(s)
  Keita Nagai, Yoshikazu HIgami, Masaki Kobayashi
- Organizer
  第１７回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Function analysis of obesity-induced E3 ubiquitin ligase, Wwp1, in the obese adipose tissue2017
- Author(s)
  Shunsuke HOSHINO, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第40回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 新たなカロリー制限の分子メカニズム　～脂肪代謝と脂肪組織のリモデリング～2015
- Author(s)
  成田匠、沖田直之、須藤結香、樋上賀一
- Organizer
  老化促進モデルマウス（SAM)研究協議会・第30回研究発表会
- Place of Presentation
  岐阜市岐阜大学サテライトキャンパス
- Year and Date
  2015-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26670193
[Presentation] カロリー制限時の白色脂肪組織におけるSrebp-1 支配的遺伝子発現変動の網羅的解析2009
- Author(s)
  仲條良和、沖田直之、伊藤麻希子、鈴木智典、宮崎智、樋上賀一
- Organizer
  第32回日本基礎老化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590396
[Presentation] Caloric restriction upregulates the Akt-Glut pathway in the white adipose tissue possibly through moderate suppression of growth hormone2008
- Author(s)
  Seongjoon Park, Komatsu T, Yamaza H, Chiba T,Higami Y,Shimokawa I
- Organizer
  第31回日本基礎老化学会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-19590227
[Presentation] Calorie restriction increases TORC2-dependent CREB activity for induction of gluconeogenetic gene expression by down-regulation of AMPK2008
- Author(s)
  Lucas S. Trindade, Komatsu T, Yamaza H, Chiba T,Higami Y,Shimokawa I
- Organizer
  第31回日本基礎老化学会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-19590227
[Presentation] foxO1 is not involved in the calorie restriction - specific response to oxidative stress in mice liver2007
- Author(s)
  Komatsu T, Fukumoto Y, Mashima H, Furuyama T, Chiba T, Yamaza H, Higami H, Shimokawa I
- Organizer
  36th Annual Meeting of American Aging Association
- Place of Presentation
  San Antonio, TX USA
- Data Source
  KAKENHI-PROJECT-19590227

1. SHIMOKAWA Isao (70187475)

# of Collaborated Projects: 14 results

# of Collaborated Products: 26 results
2. OKITA Naoyuki (60453841)

# of Collaborated Projects: 7 results

# of Collaborated Products: 16 results
3. 小林正樹 (30795612)

# of Collaborated Projects: 6 results

# of Collaborated Products: 33 results
4. CHIBA Takuya (40336152)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
5. TSUCHIYA Tomoshi (30437884)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
6. NAGAYASU Takeshi (80284686)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
7. YAMAZA Haruyoshi (30336151)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
8. AKITA Sadanori (90315250)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 中川嘉 (80361351)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
10. YAMASAKI Naoya (70404217)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. 池田高良 (50034624)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. TAGAWA Tsutomu (20363492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SUDO Yuka (70646695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. Goitsuka Ryo (50301552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小林英司 (00245044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 李桃生 (50379997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 柴田淳史 (30707633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 野口満 (00325648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 三浦ゆり (00216574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 近藤洋介 (30778204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 田川亮真 (70844455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 野崎優香 (40886511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 島野仁 (20251241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 長谷耕二 (20359714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 戸邉一之 (30251242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 草森浩輔 (90707407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
27. 西川元也 (40273437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
28. 佐々木敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 小松雅明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higami Yoshikazu 樋上 賀一

HIGAMI Yoshikazu 樋上 賀一

樋上 賀一 ヒガミ ヨシカズ

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ミトカインGDF15による末梢組織での直接的な新規代謝改善・抗炎症作用機構の解明Principal Investigator

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Reguratory mechanisms of lifespan by altered energy metabolism via splicing controlPrincipal Investigator

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Investigative research on the extention of healthy lifespan that can be applied to humans based on mitochondrial unfolded protein responsePrincipal Investigator

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Dysregulation of lysosome/mitochondrial interaction in obese adipose tissuePrincipal Investigator

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Comprehensive mitochondrial quality control and its collapse in metabolic diseasesPrincipal Investigator

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Higami Yoshikazu 樋上賀一

HIGAMI Yoshikazu 樋上賀一

樋上賀一ヒガミヨシカズ