HIGAMI Yoshikazu 樋上賀一

… Alternative Names

Researcher Number	90253640
Other IDs
External Links
Affiliation (Current)	2021: 東京理科大学, 薬学部生命創薬科学科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2021: 東京理科大学, 薬学部生命創薬科学科, 教授 2013 – 2015: 東京理科大学, 薬学部, 教授 2010 – 2011: 東京理科大学, 薬学部, 教授 2007 – 2008: Tokyo University of Science, 薬学部, 教授 2004 – 2005: 長崎大学, 大学院・医歯薬学総合研究科, 助教授 … More
Review Section/Research Field	Principal Investigator Experimental pathology / Experimental pathology / Applied health science / Basic Section 59040:Nutrition science and health science-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields Except Principal Investigator Experimental pathology / Thoracic surgery / Respiratory surgery / 老化(加齢) / Environmental physiology (including Physical medicine and Nutritional physiology) … More
Keywords	Principal Investigator カロリー制限 / 老化 / 脂肪組織 / ミトコンドリア / IGF-1 / 肝細胞 / 食餌制限 / SREBP1 / ノックアウトマウス / 脂肪細胞 … More Except Principal Investigator 老化 / カロリー制限 / 肺移植 / ラット / 肺再生 / 肺 / 再生 / 組織工学 / 脱細胞化 / 再細胞化 / マトリックス / Aging / 先天性心疾患 / 未熟心 / 刺激伝導異常 / HNK-1 / アセチルコリン・エステラーゼ / 形態学的解析 / 食餌制限 / カロリー / 下垂体 / 成長因子 / IGF-1 / bFGF / TGF / Neuropeptide Y / アディポネクチン / リポポリサッカライド / 小胞体ストレス / 肺気腫 / 肺癌 / マイクロアレイ / 虚血再灌流障害 / 脂肪幹細胞 / PARP inhibitor / 肺虚血再灌流 / ラット肺移植 / PARP阻害剤 / 脂肪肝細胞 / バイオリアクター / レプチン / 神経内分泌 / Caloric restriction / Leptin / Neuroendocrine / 長寿 / インスリン / 成長ホルモン / インスリン様成長因子 / ストレス応答 / エネルギー代謝 / Longevity / Calorie-restriction / Insulin / Growth hormone / Insulin-like growth factor / Stress response / Energy metabolism / 気管再生 / 臓器移植 / 異種移植 / 組織骨格 / 移植免疫 / 気管移植 / 再生医療 / 細胞外マトリックス / 移植 / 移植・再生医療 / 気管 / ブタ / 2型糖尿病 / 膵島 / 分化転換 / 機能疲弊 / 生活習慣病 / 食餌誘導性肝がん / CREBH / 腸肝連関 / 胎生期環境 / 免疫記憶 / B細胞 / 内臓脂肪炎症 Less

Elucidation of the mechanism of liver cancer induced by abnormal lipid metabolism in enterohepatic associationOngoing
- Principal Investigator
  
  中川嘉
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  University of Toyama
胎生期免疫記憶による内臓脂肪炎症制御機構の解明Ongoing
- Principal Investigator
  
  後飯塚僚
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Tokyo University of Science
Reguratory mechanisms of lifespan by altered energy metabolism via splicing controlPrincipal InvestigatorOngoing
- Principal Investigator
  
  樋上賀一
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science
Investigative research on the extention of healthy lifespan that can be applied to humans based on mitochondrial unfolded protein responsePrincipal InvestigatorOngoing
- Principal Investigator
  
  樋上賀一
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Tokyo University of Science
2型糖尿病個別化療法の確立を目指した糖尿病における分化転換の分子基盤の研究Ongoing
- Principal Investigator
  
  沖田直之
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science, Yamaguchi
Dysregulation of lysosome/mitochondrial interaction in obese adipose tissuePrincipal InvestigatorOngoing
- Principal Investigator
  
  樋上賀一
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo University of Science
Transplantation studies of tissue engineered tracha and lung regenerated from recellularized xenogeneic-decellularized scaffold
- Principal Investigator
  
  TSUCHIYA Tomoshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Nagasaki University
Comprehensive mitochondrial quality control and its collapse in metabolic diseasesPrincipal Investigator
- Principal Investigator
  
  Higami Yoshikazu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo University of Science
Basic researches for the improvement of the fragility and the organ portection about de-and re-cellularization based regenerated lung
- Principal Investigator
  
  TSUCHIYA Tomoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory surgery
- Research Institution
  Nagasaki University
The study of tissue protection and cell implantation effects by adipose tissue derived stromal cells for future usage in damaged or transplanted lung
- Principal Investigator
  
  TSUCHIYA Tomoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Nagasaki University
Functional Analysis of a Novel Obesity-associated E3 Ubiquitin Ligase WWP1Principal Investigator
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo University of Science
The effects of adiponectin on lung cancer and lung disease
- Principal Investigator
  
  TSUCHIYA Tomoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Nagasaki University
Mechanisms underlying the effect of calorie restriction : Analyses of neuropeptide Y and receptor subtypes
- Principal Investigator
  
  SHIMOKAWA Isao
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Nagasaki University
Suppressed cellular damage and inflammation, and altered metabolism by caloric restriction via SREBP1/LXRPrincipal Investigator
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo University of Science
Investigation of genes involved in anti-obesity and insulin sensitivity in the white adipose tissuePrincipal Investigator
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
Regulation of aging in mammals : Difference between the effects of calorie restriction and suppression of the GH-IGF-1 axis
- Principal Investigator
  
  SHIMOAKAWA Isao
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University Graduate School of Biomedical Sciences
What is the target of anti-aging action of calorie restriction?Principal Investigator
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University School of Medicine
Mechanisms underlying the anti-aging effect of caloric restriction: A role for leptin in regulation of neuroendocrine system
- Principal Investigator
  
  SHIMOKAWA Isao
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  NAGASAKI UNIVERSITY SCHOOL OF MEDICINE
加齢に伴うFas抗原発現を介する肝細胞死増強と食餌制限によるその抑制に関する研究-セラミド、DNaseγの活性化-Principal Investigator
- Principal Investigator
  
  樋上賀一
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
食餌制限による下垂体前葉細胞の加齢、腫瘍化抑制機構-成長因子の関連性について-
- Principal Investigator
  
  下川功
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Nagasaki University
肝細胞の増殖と細胞死の加齢変化および食餌制限の影響に関する細胞生物学的研究Principal Investigator
- Principal Investigator
  
  樋上賀一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
ラット先天性心疾患及び未熟児における刺激伝導異常の解析
- Principal Investigator
  
  池田高良
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
先天性刺激伝導異常の発生病理
- Principal Investigator
  
  池田高良
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University

All 2020 2019 2018 2017 2015 2014 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Patent

[Journal Article] WWP1 knockout in mice exacerbates obesity‐related phenotypes in white adipose tissue but improves whole‐body glucose metabolism2020
- Author(s)
  Hoshino Shunsuke、Kobayashi Masaki、Tagawa Ryoma、Konno Ryutaro、Abe Takuro、Furuya Kazuhiro、Miura Kumi、Wakasawa Hiroki、Okita Naoyuki、Sudo Yuka、Mizunoe Yuhei、Nakagawa Yoshimi、Nakamura Takeshi、Kawabe Hiroshi、Higami Yoshikazu
- Journal Title
  
  FEBS Open Bio
  
  Volume: 10 Pages: 306-315
- DOI
  10.1002/2211-5463.12795
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119
[Journal Article] Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes.2020
- Author(s)
  Mizunoe Yuhei、Kobayashi Masaki、Hoshino Shunsuke、Tagawa Ryoma、Itagawa Rei、Hoshino Ayana、Okita Naoyuki、Sudo Yuka、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
- Journal Title
  
  Sci Rep.
  
  Volume: 10 Pages: 634-634
- DOI
  10.1038/s41598-020-57428-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-19K11713, KAKENHI-PROJECT-18K17953, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-18H04051
[Journal Article] Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue2019
- Author(s)
  Namiki Fujii, Seira Uta, Masaki Kobayashi, Tsugumichi Sato, Naoyuki Okita, Yoshikazu Higami
- Journal Title
  
  Experimental Gerontology
  
  Volume: 118 Pages: 55-64
- DOI
  10.1016/j.exger.2019.01.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-18K11119
[Journal Article] Identification of WWP1 as an obesity-associated E3 ubiquitin ligase with a protective role against oxidative stress in adipocytes.2019
- Author(s)
  Kobayashi Masaki、Hoshino Shunsuke、Abe Takuro、Okita Naoyuki、Tagawa Ryoma、Nagai Wataru、Konno Ryutaro、Suzuki Yuki、Furuya Kazuhiro、Ishikawa Natsumi、Okado Hitoshi、Oku Misako、Iwamoto Machiko、Miura Yuri、Sudo Yuka、Higami Yoshikazu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 508 Pages: 117-122
- DOI
  10.1016/j.bbrc.2018.11.127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11119, KAKENHI-PROJECT-17K13231
[Journal Article] Differential response to caloric restriction of retroperitoneal, epididymal, and subcutaneous adipose tissue depots in rats2018
- Author(s)
  Narita Takumi、Kobayashi Masaki、Itakura Kaho、Itagawa Rei、Kabaya Riho、Sudo Yuka、Okita Naoyuki、Higami Yoshikazu
- Journal Title
  
  Exp Gerontol
  
  Volume: 104 Pages: 127-137
- DOI
  10.1016/j.exger.2018.01.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Trehalose protects against oxidative stress by regulating the Keap1/Nrf2 and autophagy pathways2018
- Author(s)
  Mizunoe Yuhei、Kobayashi Masaki、Sudo Yuka、Watanabe Shukoh、Yasukawa Hiromine、Natori Daiki、Hoshino Ayana、Negishi Arisa、Okita Naoyuki、Komatsu Masaaki、Higami Yoshikazu
- Journal Title
  
  Redox Biol
  
  Volume: 15 Pages: 115-124
- DOI
  10.1016/j.redox.2017.09.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-17H02179
[Journal Article] Differential Metabolic Responses to Adipose Atrophy Associated with Cancer Cachexia and Caloric Restriction in Rats and the Effect of Rikkunshito in Cancer Cachexia2018
- Author(s)
  Sudo Yuka、Otsuka Hiroki、Miyakawa Ryota、Goto Akifumi、Kashiwase Yohei、Terawaki Kiyoshi、Miyano Kanako、Hirao Yuto、Taki Kanari、Tagawa Ryoma、Kobayashi Masaki、Okita Naoyuki、Uezono Yasuhito、Higami Yoshikazu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 19 Pages: 3852-3852
- DOI
  10.3390/ijms19123852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K11119
[Journal Article] Modified Western blotting for insulin and other diabetes-associated peptide hormones2017
- Author(s)
  Okita N, Higami Y, Fukai F, Kobayashi M, Mitarai M, Sekiya T, Sasaki T.
- Journal Title
  
  Sci Rep
  
  Volume: 7:6949 Pages: 1-11
- DOI
  10.1038/s41598-017-04456-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461346, KAKENHI-PROJECT-17H02179
[Journal Article] A novel caloric restriction mediator2017
- Author(s)
  Kobayashi Masaki、Higami Yoshikazu
- Journal Title
  
  Aging (Albany NY)
  
  Volume: 9 Pages: 2012-2013
- DOI
  10.18632/aging.101311
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Sterol regulatory element-binding protein-1c orchestrates metabolic remodeling of white adipose tissue by caloric restriction2017
- Author(s)
  Fujii Namiki、Narita Takumi、Okita Naoyuki、Kobayashi Masaki、Furuta Yurika、Chujo Yoshikazu、Sakai Masahiro、Yamada Atsushi、Takeda Kanae、Konishi Tomokazu、Sudo Yuka、Shimokawa Isao、Higami Yoshikazu
- Journal Title
  
  Aging Cell
  
  Volume: 16 Pages: 508-517
- DOI
  10.1111/acel.12576
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction.2017
- Author(s)
  Kobayashi Masaki、Takeda Kanae、Narita Takumi、Nagai Keita、Okita Naoyuki、Sudo Yuka、Miura Yuri、Tsumoto Hiroki、Nakagawa Yoshimi、Shimano Hitoshi、Higami Yoshikazu
- Journal Title
  
  FEBS Lett
  
  Volume: 591 Pages: 4067-4073
- DOI
  10.1002/1873-3468.12914
- NAID
  120006401862
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K01811, KAKENHI-PLANNED-17H06395, KAKENHI-PROJECT-15H02541, KAKENHI-PROJECT-17K13231, KAKENHI-PROJECT-17H02179
[Journal Article] Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice2017
- Author(s)
  Mizunoe Yuhei、Sudo Yuka、Okita Naoyuki、Hiraoka Hidenori、Mikami Kentaro、Narahara Tomohiro、Negishi Arisa、Yoshida Miki、Higashibata Rikako、Watanabe Shukoh、Kaneko Hiroki、Natori Daiki、Furuichi Takuma、Yasukawa Hiromine、Kobayashi Masaki、Higami Yoshikazu
- Journal Title
  
  Autophagy
  
  Volume: 13 Pages: 642-653
- DOI
  10.1080/15548627.2016.1274850
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02179
[Journal Article] Poly(ADP-ribose) Polymerase Inhibitor (PJ34) Reduces Pulmonary Ischemia-Reperfusion Injury in Rats2014
- Author(s)
  Go Hatachi, Tomoshi Tsuchiya, Takuro Miyazaki, Keitaro Matsumoto, Naoya Yamasaki, Shingo Matsushima, Atsushi Nanashima, Yoshikazu Higami, and Takeshi Nagayasu
- Journal Title
  
  Transplantation
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592066
[Journal Article] Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain : implications for longevity2009
- Author(s)
  Chiba T, Inoue D, Mizuno A, Komatsu T, Fujita S, Kubota H, Luisa Tagliaro M, Park S, Trindade LS, Hayashida T, Hayashi H, Yamaza H, Higami Y, himokawa I
- Journal Title
  
  Neurobiol Aging 27
  
  Pages: 474-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-ccelerated mouse strain P82008
- Author(s)
  Komatsu T, Chiba T, Yamaza H, Yamashita K, Shimada A, Hoshiyama Y, Henmi T, Ohtani H, Higami Y, de Cabo R, Ingram DK, Shimokawa I
- Journal Title
  
  Exp Gerontol 43(4)
  
  Pages: 339-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Calorie restriction minimizes activation of insulin signaling in response to glucose : potential involvement of the growth hormone-insulin-like growth factor 1 axis2008
- Author(s)
  Hayashi H, Yamaza H, Komatsu T, Park S, Chiba T, Higami Y, Nagayasu T, Shimokawa I
- Journal Title
  
  Exp Gerontol 43(9)
  
  Pages: 827-32
- NAID
  120000911575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Genet ic suppression of GH-IGF-1 activity, combined with lifelong caloric restri-ction, prevents age-related renal damage and prolongs the life span in rats2008
- Author(s)
  Zha Y, Taguchi T, Nazneen A, Shimokawa I, Higami Y, Razzaque MS
- Journal Title
  
  Am J Nephrol 28(5)
  
  Pages: 755-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness : relationship with caloric restriction2008
- Author(s)
  Chiba T, Yamaza H, Komatsu T, Nakayama M, Fujita S, Hayashi H, Higami Y, Shimokawa I
- Journal Title
  
  Exp Gerontol 43(6)
  
  Pages: 595-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Identification of fasting-induced genes in the rat hypothalamus : relationship with neuroprotection2007
- Author(s)
  Chiba T, Fujita S, Kubota H, Inoue D, Mizuno A, Komatsu T, Yamaza H, Higami Y, Shimokawa I
- Journal Title
  
  Ann N Y Acad Sci. 1119
  
  Pages: 216-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver2007
- Author(s)
  To K, Yamaza H, Komatsu T, Hayashida T, Hayashi H, Toyama H, Chiba T, Higami Y, Shimokawa I
- Journal Title
  
  Exp Gerontol 42(11)
  
  Pages: 1063-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Involvement of insulin-like growth factor-1 in the effect of caloric restriction : regulation of plasma adiponectin and leptin2007
- Author(s)
  Yamaza H, Komatsu T, To K, Toyama H, Chiba T, Higami Y, Shimokawa I
- Journal Title
  
  J Gerontol A Biol Sci Med Sci. 62(1)
  
  Pages: 27-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.2006
- Author(s)
  Higami Y, Barger JL, et al.
- Journal Title
  
  J Nutr. 136・2
  
  Pages: 343-52
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Gene expression profile of caloric restriction in mouse adipose tissue : Lowered expression of genes linked to inflammation, cytoskeleton, extracellular matrix and angiogenesis2006
- Author(s)
  Higami Y, Barger JL, Page GP, Allison DB, Chen L, Smith SR, Prolla TA, Weindruch R.
- Journal Title
  
  J Nutr 136
  
  Pages: 343-352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.2006
- Author(s)
  Higami Y, Barger JL, Page GP, Allison DB, Smith SR, Prolla TA, Weindruch R
- Journal Title
  
  J Nutr 136
  
  Pages: 343-352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Role of leptin signaling in the hypothalamus in the effect of calorie restriction2006
- Author(s)
  Komatsu T, Chiba T, Yamaza H, To K, Toyama H, Higami Y, Shimokawa I.
- Journal Title
  
  J Gerontol : Bio Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Gene expression profile of caloric restriction in mouse adipose tissue : Lowered expression of genes linked to inflammation, cytoskeleton, extracellular matrix and angiogenesis2006
- Author(s)
  Higami Y
- Journal Title
  
  J Nutrition 136
  
  Pages: 343-352
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Glucose metabolism in calorie-restricted or transgenic dwarf rat : Analysis of adiponectin-AMPK pathway (in Japanese)2005
- Author(s)
  Hayashi H, Yamaza H, Tou K, Toyama H, Komatsu T, Chiba T, Higami Y, Shimokawa I.
- Journal Title
  
  Biomedical Gerontology 29
  
  Pages: 31-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation.2005
- Author(s)
  Tsuchiya T, Higami Y, Komatsu T, Tanaka K, Honda S, Yamaza H, Chiba T, Ayabe H, Shimokawa I
- Journal Title
  
  Mech Ageing Dev 126
  
  Pages: 568-579
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Laboratory findings of caloric restriction in rodents and primates2005
- Author(s)
  Higami Y
- Journal Title
  
  Adv Clin Chem 39
  
  Pages: 211-237
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation2005
- Author(s)
  Tsuchiya T, Higami Y, et al.
- Journal Title
  
  Mech Ageing Dev. 126・5
  
  Pages: 568-79
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005
- Author(s)
  Higami Y, Yamaza H, Shinozawa I.
- Journal Title
  
  Adv Clin Chem. 39
  
  Pages: 211-37
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Laboratory findings of caloric restriction in rodents and primates2005
- Author(s)
  Higami Y, Yamaza H, Shimokawa I.
- Journal Title
  
  Adv Clin Chem 39
  
  Pages: 211-237
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Glucose-insulin system in long-lived rats ; effects of calorie restriction and suppression of GH-IGF-1 axis (in Japanese)2005
- Author(s)
  Yamaza H, Komatsu T, Higami Y, Shimokawa I.
- Journal Title
  
  Biomedical Gerontology
  
  Pages: 25-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Laboratory findings of caloric restriction in rodents and primates2005
- Author(s)
  Higami Y 他
- Journal Title
  
  Adv Clin Chem 39
  
  Pages: 211-237
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005
- Author(s)
  Higami Y, Shimokawa I, Yamaza H
- Journal Title
  
  Adv Clin Chem 39
  
  Pages: 211-237
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation.2005
- Author(s)
  Tsuchiya T, Higami Y, et al.
- Journal Title
  
  Mech Ageing Dev. 126・5
  
  Pages: 568-579
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005
- Author(s)
  Higami Y, Yamaza H, Shimokawa I.
- Journal Title
  
  Adv Clin Chem. 39
  
  Pages: 211-237
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-Induced inflammation2005
- Author(s)
  Tsuchiya T, Higami Y, Komatsu T, Tanaka K, Honda S, Yamaza H, Chiba T, Ayabe H, Shimokawa I.
- Journal Title
  
  Mech Ageing and Develop 126
  
  Pages: 568-579
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes2004
- Author(s)
  Higami Y 他
- Journal Title
  
  Cell Tissue Res 316
  
  Pages: 403-407
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] カロリー制限による抗老化・寿命延長作用 -代謝の変化から見たそのメカニズム-2004
- Author(s)
  樋上賀一
- Journal Title
  
  基礎老化研究 28
  
  Pages: 15-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Aging increases DNase γ, an apoptosis-related endonuclease, in rat liver nuclei : effect of dietary restriction.2004
- Author(s)
  Tanaka K, Higami Y, Tsuchiya T, Shiokawa D1, Tanuma S1, Ayabe H2, Shimokawa I.
- Journal Title
  
  Exp Gerontol 39
  
  Pages: 195-202
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Altered energy metabolism in anti-aging and lifespan extension by caloric restriction (in Japanese)2004
- Author(s)
  Higami Y.
- Journal Title
  
  Biomedical Gerontology 28
  
  Pages: 15-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Gene expression analysis of calorie restriction by DNA microarray (in Japanese)2004
- Author(s)
  Kayo T, Higami Y, Weindruch R.
- Journal Title
  
  Experimental Medicine 2
  
  Pages: 837-841
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Altered lipid metabolism in rodents animals subjected to caloric restriction2004
- Author(s)
  Higami Y, Weindruch R, Prolla TA, Shimokawa I
- Journal Title
  
  Geriatrics Gerontol Int, 4
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] A transgenic dwarf rat model as a tool for the study of calorie restriction and aging.2004
- Author(s)
  Yamaza H, Komatsu T, Chiba T, Toyama H, To K, Higami Y, Shimokawa I.
- Journal Title
  
  Exp Gerontol 39
  
  Pages: 269-272
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes2004
- Author(s)
  Higami Y
- Journal Title
  
  Cell Tissue Res 316
  
  Pages: 403-407
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes2004
- Author(s)
  Higami Y, Tsuchiya T, To K, Chiba T, Yamaza H, Shiokawa D, Tanuma S, Shimokawa I.
- Journal Title
  
  Cell Tissue Res, 316
  
  Pages: 403-407
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Altered lipid metabolism in rodents animals subjected to caloric restriction2004
- Author(s)
  Higami Y
- Journal Title
  
  Geriatrics Gerontology International 4
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Effects of caloric restriction on gene expression in the arcuate nucleus.2003
- Author(s)
  Shimokawa I, Fukuyama T, Yanagihara-Outa K, Tomita M, Komatsu T, Higami Y, Tsuchiya T, Chiba T, Yamaza H.
- Journal Title
  
  Neurobiol Aging, 24
  
  Pages: 117-123
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis : relation to caloric restriction.2003
- Author(s)
  Shimokawa I, Higami Y, Tsuchiya T, Otani H, Komatsu T, Chiba T, Yamaza H.
- Journal Title
  
  FASEB J, 17
  
  Pages: 1108-1109
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Effect of leptin on hypothalamic gene expression in calorie-restricted rats.
- Author(s)
  Komatsu T, Chiba T, Yamaza H, To K, Toyama H, Higami Y, Isao Shimokawa I
- Journal Title
  
  J Gerontol A Biol Sci Med Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Effect of leptin on hypothalamic gene expression in calorie-restricted rats.
- Author(s)
  Komatsu T, Higami Y, et al.
- Journal Title
  
  J Gerontol A Biol Sci Med Sci in press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Hepatic gene expression profile of lipid metabolism in rats : impact of caloric restriction and growth hormone/IGF-1 suppression.
- Author(s)
  Higami Y, Tsuchiya T, et al.
- Journal Title
  
  J Gerontol A Biol Sci Med Sci in press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Hepatic gene expression profile of lipid metabolism in rats : impact of caloric restriction and growth hormone/IGF-1 suppression.
- Author(s)
  Higami Y, Tsuchiya T, Chiba T, Yamaza H, Muraoka I, Hirose M, Komatsu T, Shimokawa I
- Journal Title
  
  J Gerontol A Biol Sci Med Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Patent] 寿命延長関連遺伝子およびその用途2007
- Inventor(s)
  千葉卓哉、下川功、樋上賀一、山座治義
- Industrial Property Rights Holder
  国立大学法人長崎大学
- Industrial Property Number
  2007-061075
- Filing Date
  2007-03-07
- Data Source
  KAKENHI-PROJECT-19590227
[Presentation] Western blottingのプロトコール改変による低分子量ペプチドの分離検出-糖尿病関連ペプチドホルモンを実施例として-2019
- Author(s)
  沖田直之、樋上賀一、深井文雄、小林正樹、御手洗光来、関谷剛男、佐々木敬
- Organizer
  第60回日本生化学会中四国支部大会
- Data Source
  KAKENHI-PROJECT-18K11119
[Presentation] 短期高脂肪食摂餌モデルの脂肪組織におけるリソソーム機能破綻メカニズムの解析2018
- Author(s)
  古市拓真、水之江雄平、小林正樹、樋上賀一
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Development of an Obesity Pathology affected by Lysosomal Dysfunction2017
- Author(s)
  Rei ITAGAWA, Yuhei MIZUNOE, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第40回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 皮下脂肪と内臓脂肪におけるカロリー制限への応答の相違2017
- Author(s)
  成田匠、小林正樹、須藤結香、沖田直之、樋上賀一
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The role mitochondrial intermediate peptidase (MIPEP) in improvement of mitochondrial metabolism by Caloric Restriction2017
- Author(s)
  Keita NAGAI, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第40回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 肥満症脂肪組織における新規肥満応答因子Ｗｗｐ１の機能解析2017
- Author(s)
  星野駿介、小林正樹、樋上賀一
- Organizer
  第38回日本肥満学会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] Function analysis of obesity-induced E3 ubiquitin ligase, Wwp1, in the obese adipose tissue2017
- Author(s)
  Shunsuke HOSHINO, Masaki KOBAYASHI, Yoshikazu HIGAMI
- Organizer
  第40回日本基礎老化学会大会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The role of MIPEP in improvement of metabolism by CR2017
- Author(s)
  Keita Nagai, Yoshikazu HIgami, Masaki Kobayashi
- Organizer
  第１７回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] The Obese Pathology Affected by Lysosomal Dysfunction2017
- Author(s)
  Rei Itagawa, Yuhei Mizunoe, Masaki Kobayashi, Yoshikazu Higami
- Organizer
  第１７回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-17H02179
[Presentation] 新たなカロリー制限の分子メカニズム　～脂肪代謝と脂肪組織のリモデリング～2015
- Author(s)
  成田匠、沖田直之、須藤結香、樋上賀一
- Organizer
  老化促進モデルマウス（SAM)研究協議会・第30回研究発表会
- Place of Presentation
  岐阜市岐阜大学サテライトキャンパス
- Year and Date
  2015-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26670193
[Presentation] カロリー制限時の白色脂肪組織におけるSrebp-1 支配的遺伝子発現変動の網羅的解析2009
- Author(s)
  仲條良和、沖田直之、伊藤麻希子、鈴木智典、宮崎智、樋上賀一
- Organizer
  第32回日本基礎老化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590396
[Presentation] Caloric restriction upregulates the Akt-Glut pathway in the white adipose tissue possibly through moderate suppression of growth hormone2008
- Author(s)
  Seongjoon Park, Komatsu T, Yamaza H, Chiba T,Higami Y,Shimokawa I
- Organizer
  第31回日本基礎老化学会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-19590227
[Presentation] Calorie restriction increases TORC2-dependent CREB activity for induction of gluconeogenetic gene expression by down-regulation of AMPK2008
- Author(s)
  Lucas S. Trindade, Komatsu T, Yamaza H, Chiba T,Higami Y,Shimokawa I
- Organizer
  第31回日本基礎老化学会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-19590227
[Presentation] foxO1 is not involved in the calorie restriction - specific response to oxidative stress in mice liver2007
- Author(s)
  Komatsu T, Fukumoto Y, Mashima H, Furuyama T, Chiba T, Yamaza H, Higami H, Shimokawa I
- Organizer
  36th Annual Meeting of American Aging Association
- Place of Presentation
  San Antonio, TX USA
- Data Source
  KAKENHI-PROJECT-19590227

1. SHIMOKAWA Isao (70187475)

# of Collaborated Projects: 14 results

# of Collaborated Products: 26 results
2. OKITA Naoyuki (60453841)

# of Collaborated Projects: 6 results

# of Collaborated Products: 15 results
3. CHIBA Takuya (40336152)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
4. TSUCHIYA Tomoshi (30437884)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
5. NAGAYASU Takeshi (80284686)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
6. YAMAZA Haruyoshi (30336151)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
7. AKITA Sadanori (90315250)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 小林正樹 (30795612)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
9. 中川嘉 (80361351)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
10. YAMASAKI Naoya (70404217)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. 池田高良 (50034624)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. TAGAWA Tsutomu (20363492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SUDO Yuka (70646695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 小林英司 (00245044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 李桃生 (50379997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 野口満 (00325648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 柴田淳史 (30707633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 三浦ゆり (00216574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 近藤洋介 (30778204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 田川亮真 (70844455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 島野仁 (20251241)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. 長谷耕二 (20359714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 戸辺一之 (30251242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 後飯塚僚 (50301552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 小松雅明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 佐々木敬

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HIGAMI Yoshikazu 樋上 賀一

樋上 賀一 ヒガミ ヨシカズ

Research Projects

Research Products

Co-Researchers

Elucidation of the mechanism of liver cancer induced by abnormal lipid metabolism in enterohepatic associationOngoing

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胎生期免疫記憶による内臓脂肪炎症制御機構の解明Ongoing

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Reguratory mechanisms of lifespan by altered energy metabolism via splicing controlPrincipal InvestigatorOngoing

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Investigative research on the extention of healthy lifespan that can be applied to humans based on mitochondrial unfolded protein responsePrincipal InvestigatorOngoing

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2型糖尿病個別化療法の確立を目指した糖尿病における分化転換の分子基盤の研究Ongoing

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Dysregulation of lysosome/mitochondrial interaction in obese adipose tissuePrincipal InvestigatorOngoing

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Comprehensive mitochondrial quality control and its collapse in metabolic diseasesPrincipal Investigator

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Principal Investigator

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Functional Analysis of a Novel Obesity-associated E3 Ubiquitin Ligase WWP1Principal Investigator

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Principal Investigator

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Suppressed cellular damage and inflammation, and altered metabolism by caloric restriction via SREBP1/LXRPrincipal Investigator

Principal Investigator

HIGAMI Yoshikazu 樋上賀一

樋上賀一ヒガミヨシカズ