HIGAMI Yoshikazu 樋上賀一

Researcher Number	90253640
Other IDs
External Links
Affiliation *help	2016 – 2018 : 東京理科大学, 薬学部生命創薬科学科, 教授 2017 : 東京理科大学, 薬学部, 教授 2013 – 2015 : 東京理科大学, 薬学部, 教授 2010 – 2011 : 東京理科大学, 薬学部, 教授 2007 – 2008 : Tokyo University of Science, 薬学部, 教授 … More
Review Section/Research Field	Principal Investigator Experimental pathology / Experimental pathology / Applied health science Except Principal Investigator Respiratory surgery / Experimental pathology / Thoracic surgery / Environmental physiology (including Physical medicine and Nutritional physiology) / 老化(加齢) / Basic Section 59040:Nutrition science and health science-related / Neuroscience in general / Experimental pathology
Keywords	Principal Investigator 老化 / カロリー制限 / IGF-1 / 肥満症 / ミトコンドリア / 脂肪組織 / トランスジェニックラット / 食餌制限 / DNA chip / SREBP1 … More Except Principal Investigator 老化 / カロリー制限 / Aging / 再細胞化 / 肺移植 / 肺再生 / 肺 / マトリックス / 組織工学 / ラット / 脱細胞化 / 再生 / 肺気腫 / 成長ホルモン / Energy metabolism / 移植・再生医療 / 刺激伝導異常 / 脂肪幹細胞 / 虚血再灌流障害 / 分化転換 / 食餌制限 / アディポネクチン / バイオリアクター / レプチン / 未熟心 / リポポリサッカライド / 気管 / Neuropeptide Y / ストレス応答 / 脂肪肝細胞 / 膵島 / Longevity / カロリー / TGF / bFGF / 下垂体 / Stress response / ブタ / Calorie-restriction / Growth hormone / アセチルコリン・エステラーゼ / 異種移植 / 成長因子 / 先天性心疾患 / エネルギー代謝 / Caloric restriction / 機能疲弊 / マイクロアレイ / 形態学的解析 / インスリン様成長因子 / HNK-1 / 長寿 / 肺癌 / Leptin / インスリン / IGF-1 / PARP inhibitor / Neuroendocrine / 肺虚血再灌流 / 小胞体ストレス / 神経内分泌 / Insulin-like growth factor / 2型糖尿病 / 移植 / 気管再生 / ラット肺移植 / PARP阻害剤 / Insulin Less

2型糖尿病個別化療法の確立を目指した糖尿病における分化転換の分子基盤の研究Ongoing
- Principal Investigator
  
  沖田直之
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Tokyo University of Science, Yamaguchi
Dysregulation of lysosome/mitochondrial interaction in obese adipose tissuePrincipal InvestigatorOngoing
- Principal Investigator
  
  樋上賀一
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied health science
- Research Institution
  Tokyo University of Science
Transplantation studies of tissue engineered tracha and lung regenerated from recellularized xenogeneic-decellularized scaffoldOngoing
- Principal Investigator
  
  土谷智史
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Nagasaki University
Comprehensive mitochondrial quality control and its collapse in metabolic diseasesPrincipal Investigator
- Principal Investigator
  
  Higami Yoshikazu
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo University of Science
Basic researches for the improvement of the fragility and the organ portection about de-and re-cellularization based regenerated lung
- Principal Investigator
  
  TSUCHIYA Tomoshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory surgery
- Research Institution
  Nagasaki University
The study of tissue protection and cell implantation effects by adipose tissue derived stromal cells for future usage in damaged or transplanted lung
- Principal Investigator
  
  TSUCHIYA Tomoshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Nagasaki University
Functional Analysis of a Novel Obesity-associated E3 Ubiquitin Ligase WWP1Principal Investigator
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo University of Science
The effects of adiponectin on lung cancer and lung disease
- Principal Investigator
  
  TSUCHIYA Tomoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Nagasaki University
Mechanisms underlying the effect of calorie restriction : Analyses of neuropeptide Y and receptor subtypes
- Principal Investigator
  
  SHIMOKAWA Isao
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental physiology (including Physical medicine and Nutritional physiology)
- Research Institution
  Nagasaki University
Suppressed cellular damage and inflammation, and altered metabolism by caloric restriction via SREBP1/LXRPrincipal Investigator
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo University of Science
Investigation of genes involved in anti-obesity and insulin sensitivity in the white adipose tissuePrincipal Investigator
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
Regulation of aging in mammals : Difference between the effects of calorie restriction and suppression of the GH-IGF-1 axis
- Principal Investigator
  
  SHIMOAKAWA Isao
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University Graduate School of Biomedical Sciences
What is the target of anti-aging action of calorie restriction?Principal Investigator
- Principal Investigator
  
  HIGAMI Yoshikazu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University School of Medicine
Mechanisms underlying the anti-aging effect of caloric restriction: A role for leptin in regulation of neuroendocrine system
- Principal Investigator
  
  SHIMOKAWA Isao
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  NAGASAKI UNIVERSITY SCHOOL OF MEDICINE
加齢に伴うFas抗原発現を介する肝細胞死増強と食餌制限によるその抑制に関する研究-セラミド、DNaseγの活性化-Principal Investigator
- Principal Investigator
  
  樋上賀一
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
食餌制限による下垂体前葉細胞の加齢、腫瘍化抑制機構-成長因子の関連性について-
- Principal Investigator
  
  下川功
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Nagasaki University
肝細胞の増殖と細胞死の加齢変化および食餌制限の影響に関する細胞生物学的研究Principal Investigator
- Principal Investigator
  
  樋上賀一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
ラット先天性心疾患及び未熟児における刺激伝導異常の解析
- Principal Investigator
  
  池田高良
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University
先天性刺激伝導異常の発生病理
- Principal Investigator
  
  池田高良
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Nagasaki University

All 2015 2014 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation

[Journal Article] Poly(ADP-ribose) Polymerase Inhibitor (PJ34) Reduces Pulmonary Ischemia-Reperfusion Injury in Rats2014
- Author(s)
  Go Hatachi, Tomoshi Tsuchiya, Takuro Miyazaki, Keitaro Matsumoto, Naoya Yamasaki, Shingo Matsushima, Atsushi Nanashima, Yoshikazu Higami, and Takeshi Nagayasu
- Journal Title
  
  Transplantation
  
  Volume : (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592066
[Journal Article] Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain : implications for longevity2009
- Author(s)
  Chiba T, Inoue D, Mizuno A, Komatsu T, Fujita S, Kubota H, Luisa Tagliaro M, Park S, Trindade LS, Hayashida T, Hayashi H, Yamaza H, Higami Y, himokawa I
- Journal Title
  
  Neurobiol Aging 27
  
  Pages : 474-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness : relationship with caloric restriction2008
- Author(s)
  Chiba T, Yamaza H, Komatsu T, Nakayama M, Fujita S, Hayashi H, Higami Y, Shimokawa I
- Journal Title
  
  Exp Gerontol 43(6)
  
  Pages : 595-600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Genet ic suppression of GH-IGF-1 activity, combined with lifelong caloric restri-ction, prevents age-related renal damage and prolongs the life span in rats2008
- Author(s)
  Zha Y, Taguchi T, Nazneen A, Shimokawa I, Higami Y, Razzaque MS
- Journal Title
  
  Am J Nephrol 28(5)
  
  Pages : 755-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-ccelerated mouse strain P82008
- Author(s)
  Komatsu T, Chiba T, Yamaza H, Yamashita K, Shimada A, Hoshiyama Y, Henmi T, Ohtani H, Higami Y, de Cabo R, Ingram DK, Shimokawa I
- Journal Title
  
  Exp Gerontol 43(4)
  
  Pages : 339-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Calorie restriction minimizes activation of insulin signaling in response to glucose : potential involvement of the growth hormone-insulin-like growth factor 1 axis2008
- Author(s)
  Hayashi H, Yamaza H, Komatsu T, Park S, Chiba T, Higami Y, Nagayasu T, Shimokawa I
- Journal Title
  
  Exp Gerontol 43(9)
  
  Pages : 827-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Identification of fasting-induced genes in the rat hypothalamus : relationship with neuroprotection2007
- Author(s)
  Chiba T, Fujita S, Kubota H, Inoue D, Mizuno A, Komatsu T, Yamaza H, Higami Y, Shimokawa I
- Journal Title
  
  Ann N Y Acad Sci. 1119
  
  Pages : 216-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver2007
- Author(s)
  To K, Yamaza H, Komatsu T, Hayashida T, Hayashi H, Toyama H, Chiba T, Higami Y, Shimokawa I
- Journal Title
  
  Exp Gerontol 42(11)
  
  Pages : 1063-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Involvement of insulin-like growth factor-1 in the effect of caloric restriction : regulation of plasma adiponectin and leptin2007
- Author(s)
  Yamaza H, Komatsu T, To K, Toyama H, Chiba T, Higami Y, Shimokawa I
- Journal Title
  
  J Gerontol A Biol Sci Med Sci. 62(1)
  
  Pages : 27-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590227
[Journal Article] Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.2006
- Author(s)
  Higami Y, Barger JL, et al.
- Journal Title
  
  J Nutr. 136・2
  
  Pages : 343-352
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Gene expression profile of caloric restriction in mouse adipose tissue : Lowered expression of genes linked to inflammation, cytoskeleton, extracellular matrix and angiogenesis2006
- Author(s)
  Higami Y, Barger JL, Page GP, Allison DB, Chen L, Smith SR, Prolla TA, Weindruch R.
- Journal Title
  
  J Nutr 136
  
  Pages : 343-352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Role of leptin signaling in the hypothalamus in the effect of calorie restriction2006
- Author(s)
  Komatsu T, Chiba T, Yamaza H, To K, Toyama H, Higami Y, Shimokawa I.
- Journal Title
  
  J Gerontol : Bio Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Gene expression profile of caloric restriction in mouse adipose tissue : Lowered expression of genes linked to inflammation, cytoskeleton, extracellular matrix and angiogenesis2006
- Author(s)
  Higami Y
- Journal Title
  
  J Nutrition 136
  
  Pages : 343-352
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.2006
- Author(s)
  Higami Y, Barger JL, Page GP, Allison DB, Smith SR, Prolla TA, Weindruch R
- Journal Title
  
  J Nutr 136
  
  Pages : 343-352
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.2006
- Author(s)
  Higami Y, Barger JL, et al.
- Journal Title
  
  J Nutr. 136・2
  
  Pages : 343-52
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Laboratory findings of caloric restriction in rodents and primates2005
- Author(s)
  Higami Y 他
- Journal Title
  
  Adv Clin Chem 39
  
  Pages : 211-237
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Laboratory findings of caloric restriction in rodents and primates2005
- Author(s)
  Higami Y
- Journal Title
  
  Adv Clin Chem 39
  
  Pages : 211-237
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation.2005
- Author(s)
  Tsuchiya T, Higami Y, et al.
- Journal Title
  
  Mech Ageing Dev. 126・5
  
  Pages : 568-579
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Glucose metabolism in calorie-restricted or transgenic dwarf rat : Analysis of adiponectin-AMPK pathway (in Japanese)2005
- Author(s)
  Hayashi H, Yamaza H, Tou K, Toyama H, Komatsu T, Chiba T, Higami Y, Shimokawa I.
- Journal Title
  
  Biomedical Gerontology 29
  
  Pages : 31-34
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Laboratory findings of caloric restriction in rodents and primates2005
- Author(s)
  Higami Y, Yamaza H, Shimokawa I.
- Journal Title
  
  Adv Clin Chem 39
  
  Pages : 211-237
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Glucose-insulin system in long-lived rats ; effects of calorie restriction and suppression of GH-IGF-1 axis (in Japanese)2005
- Author(s)
  Yamaza H, Komatsu T, Higami Y, Shimokawa I.
- Journal Title
  
  Biomedical Gerontology
  
  Pages : 25-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-Induced inflammation2005
- Author(s)
  Tsuchiya T, Higami Y, Komatsu T, Tanaka K, Honda S, Yamaza H, Chiba T, Ayabe H, Shimokawa I.
- Journal Title
  
  Mech Ageing and Develop 126
  
  Pages : 568-579
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005
- Author(s)
  Higami Y, Shimokawa I, Yamaza H
- Journal Title
  
  Adv Clin Chem 39
  
  Pages : 211-237
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005
- Author(s)
  Higami Y, Yamaza H, Shimokawa I.
- Journal Title
  
  Adv Clin Chem. 39
  
  Pages : 211-237
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005
- Author(s)
  Higami Y, Yamaza H, Shinozawa I.
- Journal Title
  
  Adv Clin Chem. 39
  
  Pages : 211-37
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation2005
- Author(s)
  Tsuchiya T, Higami Y, et al.
- Journal Title
  
  Mech Ageing Dev. 126・5
  
  Pages : 568-79
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation.2005
- Author(s)
  Tsuchiya T, Higami Y, Komatsu T, Tanaka K, Honda S, Yamaza H, Chiba T, Ayabe H, Shimokawa I
- Journal Title
  
  Mech Ageing Dev 126
  
  Pages : 568-579
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] A transgenic dwarf rat model as a tool for the study of calorie restriction and aging.2004
- Author(s)
  Yamaza H, Komatsu T, Chiba T, Toyama H, To K, Higami Y, Shimokawa I.
- Journal Title
  
  Exp Gerontol 39
  
  Pages : 269-272
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Aging increases DNase γ, an apoptosis-related endonuclease, in rat liver nuclei : effect of dietary restriction.2004
- Author(s)
  Tanaka K, Higami Y, Tsuchiya T, Shiokawa D1, Tanuma S1, Ayabe H2, Shimokawa I.
- Journal Title
  
  Exp Gerontol 39
  
  Pages : 195-202
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Gene expression analysis of calorie restriction by DNA microarray (in Japanese)2004
- Author(s)
  Kayo T, Higami Y, Weindruch R.
- Journal Title
  
  Experimental Medicine 2
  
  Pages : 837-841
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Altered energy metabolism in anti-aging and lifespan extension by caloric restriction (in Japanese)2004
- Author(s)
  Higami Y.
- Journal Title
  
  Biomedical Gerontology 28
  
  Pages : 15-20
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes2004
- Author(s)
  Higami Y
- Journal Title
  
  Cell Tissue Res 316
  
  Pages : 403-407
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] カロリー制限による抗老化・寿命延長作用 -代謝の変化から見たそのメカニズム-2004
- Author(s)
  樋上賀一
- Journal Title
  
  基礎老化研究 28
  
  Pages : 15-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes2004
- Author(s)
  Higami Y, Tsuchiya T, To K, Chiba T, Yamaza H, Shiokawa D, Tanuma S, Shimokawa I.
- Journal Title
  
  Cell Tissue Res, 316
  
  Pages : 403-407
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes2004
- Author(s)
  Higami Y 他
- Journal Title
  
  Cell Tissue Res 316
  
  Pages : 403-407
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Altered lipid metabolism in rodents animals subjected to caloric restriction2004
- Author(s)
  Higami Y
- Journal Title
  
  Geriatrics Gerontology International 4
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Altered lipid metabolism in rodents animals subjected to caloric restriction2004
- Author(s)
  Higami Y, Weindruch R, Prolla TA, Shimokawa I
- Journal Title
  
  Geriatrics Gerontol Int, 4
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis : relation to caloric restriction.2003
- Author(s)
  Shimokawa I, Higami Y, Tsuchiya T, Otani H, Komatsu T, Chiba T, Yamaza H.
- Journal Title
  
  FASEB J, 17
  
  Pages : 1108-1109
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Effects of caloric restriction on gene expression in the arcuate nucleus.2003
- Author(s)
  Shimokawa I, Fukuyama T, Yanagihara-Outa K, Tomita M, Komatsu T, Higami Y, Tsuchiya T, Chiba T, Yamaza H.
- Journal Title
  
  Neurobiol Aging, 24
  
  Pages : 117-123
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390128
[Journal Article] Hepatic gene expression profile of lipid metabolism in rats : impact of caloric restriction and growth hormone/IGF-1 suppression.
- Author(s)
  Higami Y, Tsuchiya T, Chiba T, Yamaza H, Muraoka I, Hirose M, Komatsu T, Shimokawa I
- Journal Title
  
  J Gerontol A Biol Sci Med Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Hepatic gene expression profile of lipid metabolism in rats : impact of caloric restriction and growth hormone/IGF-1 suppression.
- Author(s)
  Higami Y, Tsuchiya T, et al.
- Journal Title
  
  J Gerontol A Biol Sci Med Sci in press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Effect of leptin on hypothalamic gene expression in calorie-restricted rats.
- Author(s)
  Komatsu T, Higami Y, et al.
- Journal Title
  
  J Gerontol A Biol Sci Med Sci in press
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Journal Article] Effect of leptin on hypothalamic gene expression in calorie-restricted rats.
- Author(s)
  Komatsu T, Chiba T, Yamaza H, To K, Toyama H, Higami Y, Isao Shimokawa I
- Journal Title
  
  J Gerontol A Biol Sci Med Sci (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590317
[Presentation] 新たなカロリー制限の分子メカニズム　～脂肪代謝と脂肪組織のリモデリング～2015
- Author(s)
  成田匠、沖田直之、須藤結香、樋上賀一
- Organizer
  老化促進モデルマウス（SAM)研究協議会・第30回研究発表会
- Place of Presentation
  岐阜市岐阜大学サテライトキャンパス
- Year and Date
  2015-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-26670193
[Presentation] カロリー制限時の白色脂肪組織におけるSrebp-1 支配的遺伝子発現変動の網羅的解析2009
- Author(s)
  仲條良和、沖田直之、伊藤麻希子、鈴木智典、宮崎智、樋上賀一
- Organizer
  第32回日本基礎老化学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19590396
[Presentation] Caloric restriction upregulates the Akt-Glut pathway in the white adipose tissue possibly through moderate suppression of growth hormone2008
- Author(s)
  Seongjoon Park, Komatsu T, Yamaza H, Chiba T,Higami Y,Shimokawa I
- Organizer
  第31回日本基礎老化学会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-19590227
[Presentation] Calorie restriction increases TORC2-dependent CREB activity for induction of gluconeogenetic gene expression by down-regulation of AMPK2008
- Author(s)
  Lucas S. Trindade, Komatsu T, Yamaza H, Chiba T,Higami Y,Shimokawa I
- Organizer
  第31回日本基礎老化学会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-19590227
[Presentation] foxO1 is not involved in the calorie restriction - specific response to oxidative stress in mice liver2007
- Author(s)
  Komatsu T, Fukumoto Y, Mashima H, Furuyama T, Chiba T, Yamaza H, Higami H, Shimokawa I
- Organizer
  36th Annual Meeting of American Aging Association
- Place of Presentation
  San Antonio, TX USA
- Data Source
  KAKENHI-PROJECT-19590227

1. SHIMOKAWA Isao (70187475)

# of Collaborated Projects : 13results

# of Collaborated Products : 26results
2. OKITA Naoyuki (60453841)

# of Collaborated Projects : 5results

# of Collaborated Products : 2results
3. CHIBA Takuya (40336152)

# of Collaborated Projects : 4results

# of Collaborated Products : 17results
4. TSUCHIYA Tomoshi (30437884)

# of Collaborated Projects : 4results

# of Collaborated Products : 1results
5. NAGAYASU Takeshi (80284686)

# of Collaborated Projects : 4results

# of Collaborated Products : 1results
6. YAMAZA Haruyoshi (30336151)

# of Collaborated Projects : 3results

# of Collaborated Products : 25results
7. AKITA Sadanori (90315250)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
8. YAMASAKI Naoya (70404217)

# of Collaborated Projects : 2results

# of Collaborated Products : 1results
9. 池田高良 (50034624)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
10. TAGAWA Tsutomu (20363492)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. SUDO Yuka (70646695)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
12. 小林英司 (00245044)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. 李桃生 (50379997)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. 野口満 (00325648)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. 小林正樹 (30795612)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. 中川嘉 (80361351)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. 柴田淳史 (30707633)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

HIGAMI Yoshikazu 樋上 賀一

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2型糖尿病個別化療法の確立を目指した糖尿病における分化転換の分子基盤の研究Ongoing

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Dysregulation of lysosome/mitochondrial interaction in obese adipose tissuePrincipal InvestigatorOngoing

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Transplantation studies of tissue engineered tracha and lung regenerated from recellularized xenogeneic-decellularized scaffoldOngoing

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Comprehensive mitochondrial quality control and its collapse in metabolic diseasesPrincipal Investigator

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Functional Analysis of a Novel Obesity-associated E3 Ubiquitin Ligase WWP1Principal Investigator

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Suppressed cellular damage and inflammation, and altered metabolism by caloric restriction via SREBP1/LXRPrincipal Investigator

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Investigation of genes involved in anti-obesity and insulin sensitivity in the white adipose tissuePrincipal Investigator

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What is the target of anti-aging action of calorie restriction?Principal Investigator

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HIGAMI Yoshikazu 樋上賀一