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HIGAMI Yoshikazu  樋上 賀一

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Researcher Number 90253640
Other IDs
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Affiliation *help 2016 – 2018 : 東京理科大学, 薬学部生命創薬科学科, 教授
2017 : 東京理科大学, 薬学部, 教授
2013 – 2015 : 東京理科大学, 薬学部, 教授
2010 – 2011 : 東京理科大学, 薬学部, 教授
2007 – 2008 : Tokyo University of Science, 薬学部, 教授 … More
2004 – 2005 : 長崎大学, 大学院・医歯薬学総合研究科, 助教授
2000 – 2001 : 長崎大学, 医学部, 助教授
1998 – 1999 : 長崎大学, 医学部, 講師
1994 – 1996 : 長崎大学, 医学部, 講師
1993 : 長崎大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Experimental pathology / Experimental pathology / Applied health science
Except Principal Investigator
Respiratory surgery / Experimental pathology / Thoracic surgery / Environmental physiology (including Physical medicine and Nutritional physiology) / 老化(加齢) / Basic Section 59040:Nutrition science and health science-related / Neuroscience in general / Experimental pathology
Keywords
Principal Investigator
老化 / カロリー制限 / IGF-1 / 肥満症 / ミトコンドリア / 脂肪組織 / トランスジェニックラット / 食餌制限 / DNA chip / SREBP1 … More / 肝細胞 / DNA array / ノックアウトマウス / SIRT3 / 脂質代謝 / リソソーム / WWP1 / ミトコンドリア品質管理 / 品質管理 / Forkhead transcription factor / insulin sensitivity / 細胞死 / white adipose tissue / ミトファジー / アディポネクチン / transgenic rat / SREBPI / ミトコンドリアシグナルペプチダーゼ / 細胞増殖 / liver / アポトーシス / lipid metabolism / ミトコンドリアシグナルペプチターゼ / growth hormonef(GH)IGF-1 / シグナルペプチダーゼ / 職餌制限 / Mipep / PINK1/PARKIN / GH / calorie restriction(CR) / calorie restriction / PCNA / Sirt3 / 寿命 / Srebp-1c / 脂肪細胞 / TUNEL / セラミド / Forkhead転写因子 / Fas ligand / アディポサイトカイン / 寿命延長 / SREBP-1 / 肝臓 / ミトコンドリア病 / 成長ホルモン / transgenic rats / サイクロヘキシミド / p53 / 細胞傷害 / DNaseγ / 白色脂肪組織 / LXR / growth hormone / ユビキチンリガーゼ / adipocytokine / 炎症 / aging / ミトコンドリアの品質管理 / Fas / 白色脂肪組織(WAT) / インシュリン感受性 / DNase γ / カロリーの制限(CR) / 食餌カロリー制限 … More
Except Principal Investigator
老化 / カロリー制限 / Aging / 再細胞化 / 肺移植 / 肺再生 / 肺 / マトリックス / 組織工学 / ラット / 脱細胞化 / 再生 / 肺気腫 / 成長ホルモン / Energy metabolism / 移植・再生医療 / 刺激伝導異常 / 脂肪幹細胞 / 虚血再灌流障害 / 分化転換 / 食餌制限 / アディポネクチン / バイオリアクター / レプチン / 未熟心 / リポポリサッカライド / 気管 / Neuropeptide Y / ストレス応答 / 脂肪肝細胞 / 膵島 / Longevity / カロリー / TGF / bFGF / 下垂体 / Stress response / ブタ / Calorie-restriction / Growth hormone / アセチルコリン・エステラーゼ / 異種移植 / 成長因子 / 先天性心疾患 / エネルギー代謝 / Caloric restriction / 機能疲弊 / マイクロアレイ / 形態学的解析 / インスリン様成長因子 / HNK-1 / 長寿 / 肺癌 / Leptin / インスリン / IGF-1 / PARP inhibitor / Neuroendocrine / 肺虚血再灌流 / 小胞体ストレス / 神経内分泌 / Insulin-like growth factor / 2型糖尿病 / 移植 / 気管再生 / ラット肺移植 / PARP阻害剤 / Insulin Less
  • Research Projects

    (19results)
  • Research Products

    (47results)
  • Co-Researchers

    (17People)
  •  2型糖尿病個別化療法の確立を目指した糖尿病における分化転換の分子基盤の研究Ongoing

    • Principal Investigator
      沖田 直之
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Tokyo University of Science, Yamaguchi
  •  Dysregulation of lysosome/mitochondrial interaction in obese adipose tissuePrincipal InvestigatorOngoing

    • Principal Investigator
      樋上 賀一
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied health science
    • Research Institution
      Tokyo University of Science
  •  Transplantation studies of tissue engineered tracha and lung regenerated from recellularized xenogeneic-decellularized scaffoldOngoing

    • Principal Investigator
      土谷 智史
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory surgery
    • Research Institution
      Nagasaki University
  •  Comprehensive mitochondrial quality control and its collapse in metabolic diseasesPrincipal Investigator

    • Principal Investigator
      Higami Yoshikazu
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo University of Science
  •  Basic researches for the improvement of the fragility and the organ portection about de-and re-cellularization based regenerated lung

    • Principal Investigator
      TSUCHIYA Tomoshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Respiratory surgery
    • Research Institution
      Nagasaki University
  •  The study of tissue protection and cell implantation effects by adipose tissue derived stromal cells for future usage in damaged or transplanted lung

    • Principal Investigator
      TSUCHIYA Tomoshi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Nagasaki University
  •  Functional Analysis of a Novel Obesity-associated E3 Ubiquitin Ligase WWP1Principal Investigator

    • Principal Investigator
      HIGAMI Yoshikazu
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo University of Science
  •  The effects of adiponectin on lung cancer and lung disease

    • Principal Investigator
      TSUCHIYA Tomoshi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Nagasaki University
  •  Mechanisms underlying the effect of calorie restriction : Analyses of neuropeptide Y and receptor subtypes

    • Principal Investigator
      SHIMOKAWA Isao
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental physiology (including Physical medicine and Nutritional physiology)
    • Research Institution
      Nagasaki University
  •  Suppressed cellular damage and inflammation, and altered metabolism by caloric restriction via SREBP1/LXRPrincipal Investigator

    • Principal Investigator
      HIGAMI Yoshikazu
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Tokyo University of Science
  •  Investigation of genes involved in anti-obesity and insulin sensitivity in the white adipose tissuePrincipal Investigator

    • Principal Investigator
      HIGAMI Yoshikazu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University
  •  Regulation of aging in mammals : Difference between the effects of calorie restriction and suppression of the GH-IGF-1 axis

    • Principal Investigator
      SHIMOAKAWA Isao
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University Graduate School of Biomedical Sciences
  •  What is the target of anti-aging action of calorie restriction?Principal Investigator

    • Principal Investigator
      HIGAMI Yoshikazu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University School of Medicine
  •  Mechanisms underlying the anti-aging effect of caloric restriction: A role for leptin in regulation of neuroendocrine system

    • Principal Investigator
      SHIMOKAWA Isao
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neuroscience in general
    • Research Institution
      NAGASAKI UNIVERSITY SCHOOL OF MEDICINE
  •  加齢に伴うFas抗原発現を介する肝細胞死増強と食餌制限によるその抑制に関する研究-セラミド、DNaseγの活性化-Principal Investigator

    • Principal Investigator
      樋上 賀一
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University
  •  食餌制限による下垂体前葉細胞の加齢、腫瘍化抑制機構-成長因子の関連性について-

    • Principal Investigator
      下川 功
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      老化(加齢)
    • Research Institution
      Nagasaki University
  •  肝細胞の増殖と細胞死の加齢変化および食餌制限の影響に関する細胞生物学的研究Principal Investigator

    • Principal Investigator
      樋上 賀一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University
  •  ラット先天性心疾患及び未熟児における刺激伝導異常の解析

    • Principal Investigator
      池田 高良
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University
  •  先天性刺激伝導異常の発生病理

    • Principal Investigator
      池田 高良
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Nagasaki University

All 2015 2014 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation

  • [Journal Article] Poly(ADP-ribose) Polymerase Inhibitor (PJ34) Reduces Pulmonary Ischemia-Reperfusion Injury in Rats2014

    • Author(s)
      Go Hatachi, Tomoshi Tsuchiya, Takuro Miyazaki, Keitaro Matsumoto, Naoya Yamasaki, Shingo Matsushima, Atsushi Nanashima, Yoshikazu Higami, and Takeshi Nagayasu
    • Journal Title

      Transplantation

      Volume : (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592066
  • [Journal Article] Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain : implications for longevity2009

    • Author(s)
      Chiba T, Inoue D, Mizuno A, Komatsu T, Fujita S, Kubota H, Luisa Tagliaro M, Park S, Trindade LS, Hayashida T, Hayashi H, Yamaza H, Higami Y, himokawa I
    • Journal Title

      Neurobiol Aging 27

      Pages : 474-82

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness : relationship with caloric restriction2008

    • Author(s)
      Chiba T, Yamaza H, Komatsu T, Nakayama M, Fujita S, Hayashi H, Higami Y, Shimokawa I
    • Journal Title

      Exp Gerontol 43(6)

      Pages : 595-600

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Genet ic suppression of GH-IGF-1 activity, combined with lifelong caloric restri-ction, prevents age-related renal damage and prolongs the life span in rats2008

    • Author(s)
      Zha Y, Taguchi T, Nazneen A, Shimokawa I, Higami Y, Razzaque MS
    • Journal Title

      Am J Nephrol 28(5)

      Pages : 755-64

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-ccelerated mouse strain P82008

    • Author(s)
      Komatsu T, Chiba T, Yamaza H, Yamashita K, Shimada A, Hoshiyama Y, Henmi T, Ohtani H, Higami Y, de Cabo R, Ingram DK, Shimokawa I
    • Journal Title

      Exp Gerontol 43(4)

      Pages : 339-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Calorie restriction minimizes activation of insulin signaling in response to glucose : potential involvement of the growth hormone-insulin-like growth factor 1 axis2008

    • Author(s)
      Hayashi H, Yamaza H, Komatsu T, Park S, Chiba T, Higami Y, Nagayasu T, Shimokawa I
    • Journal Title

      Exp Gerontol 43(9)

      Pages : 827-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Identification of fasting-induced genes in the rat hypothalamus : relationship with neuroprotection2007

    • Author(s)
      Chiba T, Fujita S, Kubota H, Inoue D, Mizuno A, Komatsu T, Yamaza H, Higami Y, Shimokawa I
    • Journal Title

      Ann N Y Acad Sci. 1119

      Pages : 216-26

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver2007

    • Author(s)
      To K, Yamaza H, Komatsu T, Hayashida T, Hayashi H, Toyama H, Chiba T, Higami Y, Shimokawa I
    • Journal Title

      Exp Gerontol 42(11)

      Pages : 1063-71

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Involvement of insulin-like growth factor-1 in the effect of caloric restriction : regulation of plasma adiponectin and leptin2007

    • Author(s)
      Yamaza H, Komatsu T, To K, Toyama H, Chiba T, Higami Y, Shimokawa I
    • Journal Title

      J Gerontol A Biol Sci Med Sci. 62(1)

      Pages : 27-33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Journal Article] Gene expression profile of caloric restriction in mouse adipose tissue : Lowered expression of genes linked to inflammation, cytoskeleton, extracellular matrix and angiogenesis2006

    • Author(s)
      Higami Y, Barger JL, Page GP, Allison DB, Chen L, Smith SR, Prolla TA, Weindruch R.
    • Journal Title

      J Nutr 136

      Pages : 343-352

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Role of leptin signaling in the hypothalamus in the effect of calorie restriction2006

    • Author(s)
      Komatsu T, Chiba T, Yamaza H, To K, Toyama H, Higami Y, Shimokawa I.
    • Journal Title

      J Gerontol : Bio Sci (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Gene expression profile of caloric restriction in mouse adipose tissue : Lowered expression of genes linked to inflammation, cytoskeleton, extracellular matrix and angiogenesis2006

    • Author(s)
      Higami Y
    • Journal Title

      J Nutrition 136

      Pages : 343-352

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.2006

    • Author(s)
      Higami Y, Barger JL, Page GP, Allison DB, Smith SR, Prolla TA, Weindruch R
    • Journal Title

      J Nutr 136

      Pages : 343-352

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue.2006

    • Author(s)
      Higami Y, Barger JL, et al.
    • Journal Title

      J Nutr. 136・2

      Pages : 343-52

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Laboratory findings of caloric restriction in rodents and primates2005

    • Author(s)
      Higami Y 他
    • Journal Title

      Adv Clin Chem 39

      Pages : 211-237

    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Laboratory findings of caloric restriction in rodents and primates2005

    • Author(s)
      Higami Y
    • Journal Title

      Adv Clin Chem 39

      Pages : 211-237

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation.2005

    • Author(s)
      Tsuchiya T, Higami Y, et al.
    • Journal Title

      Mech Ageing Dev. 126・5

      Pages : 568-579

    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Glucose metabolism in calorie-restricted or transgenic dwarf rat : Analysis of adiponectin-AMPK pathway (in Japanese)2005

    • Author(s)
      Hayashi H, Yamaza H, Tou K, Toyama H, Komatsu T, Chiba T, Higami Y, Shimokawa I.
    • Journal Title

      Biomedical Gerontology 29

      Pages : 31-34

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Laboratory findings of caloric restriction in rodents and primates2005

    • Author(s)
      Higami Y, Yamaza H, Shimokawa I.
    • Journal Title

      Adv Clin Chem 39

      Pages : 211-237

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Glucose-insulin system in long-lived rats ; effects of calorie restriction and suppression of GH-IGF-1 axis (in Japanese)2005

    • Author(s)
      Yamaza H, Komatsu T, Higami Y, Shimokawa I.
    • Journal Title

      Biomedical Gerontology

      Pages : 25-29

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-Induced inflammation2005

    • Author(s)
      Tsuchiya T, Higami Y, Komatsu T, Tanaka K, Honda S, Yamaza H, Chiba T, Ayabe H, Shimokawa I.
    • Journal Title

      Mech Ageing and Develop 126

      Pages : 568-579

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005

    • Author(s)
      Higami Y, Shimokawa I, Yamaza H
    • Journal Title

      Adv Clin Chem 39

      Pages : 211-237

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005

    • Author(s)
      Higami Y, Yamaza H, Shimokawa I.
    • Journal Title

      Adv Clin Chem. 39

      Pages : 211-237

    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Laboratory findings of caloric restriction in rodents and primates.2005

    • Author(s)
      Higami Y, Yamaza H, Shinozawa I.
    • Journal Title

      Adv Clin Chem. 39

      Pages : 211-37

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation2005

    • Author(s)
      Tsuchiya T, Higami Y, et al.
    • Journal Title

      Mech Ageing Dev. 126・5

      Pages : 568-79

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation.2005

    • Author(s)
      Tsuchiya T, Higami Y, Komatsu T, Tanaka K, Honda S, Yamaza H, Chiba T, Ayabe H, Shimokawa I
    • Journal Title

      Mech Ageing Dev 126

      Pages : 568-579

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] A transgenic dwarf rat model as a tool for the study of calorie restriction and aging.2004

    • Author(s)
      Yamaza H, Komatsu T, Chiba T, Toyama H, To K, Higami Y, Shimokawa I.
    • Journal Title

      Exp Gerontol 39

      Pages : 269-272

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Aging increases DNase γ, an apoptosis-related endonuclease, in rat liver nuclei : effect of dietary restriction.2004

    • Author(s)
      Tanaka K, Higami Y, Tsuchiya T, Shiokawa D1, Tanuma S1, Ayabe H2, Shimokawa I.
    • Journal Title

      Exp Gerontol 39

      Pages : 195-202

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Gene expression analysis of calorie restriction by DNA microarray (in Japanese)2004

    • Author(s)
      Kayo T, Higami Y, Weindruch R.
    • Journal Title

      Experimental Medicine 2

      Pages : 837-841

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Altered energy metabolism in anti-aging and lifespan extension by caloric restriction (in Japanese)2004

    • Author(s)
      Higami Y.
    • Journal Title

      Biomedical Gerontology 28

      Pages : 15-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes2004

    • Author(s)
      Higami Y
    • Journal Title

      Cell Tissue Res 316

      Pages : 403-407

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] カロリー制限による抗老化・寿命延長作用 -代謝の変化から見たそのメカニズム-2004

    • Author(s)
      樋上 賀一
    • Journal Title

      基礎老化研究 28

      Pages : 15-20

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes2004

    • Author(s)
      Higami Y, Tsuchiya T, To K, Chiba T, Yamaza H, Shiokawa D, Tanuma S, Shimokawa I.
    • Journal Title

      Cell Tissue Res, 316

      Pages : 403-407

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes2004

    • Author(s)
      Higami Y 他
    • Journal Title

      Cell Tissue Res 316

      Pages : 403-407

    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Altered lipid metabolism in rodents animals subjected to caloric restriction2004

    • Author(s)
      Higami Y
    • Journal Title

      Geriatrics Gerontology International 4

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Altered lipid metabolism in rodents animals subjected to caloric restriction2004

    • Author(s)
      Higami Y, Weindruch R, Prolla TA, Shimokawa I
    • Journal Title

      Geriatrics Gerontol Int, 4

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis : relation to caloric restriction.2003

    • Author(s)
      Shimokawa I, Higami Y, Tsuchiya T, Otani H, Komatsu T, Chiba T, Yamaza H.
    • Journal Title

      FASEB J, 17

      Pages : 1108-1109

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Effects of caloric restriction on gene expression in the arcuate nucleus.2003

    • Author(s)
      Shimokawa I, Fukuyama T, Yanagihara-Outa K, Tomita M, Komatsu T, Higami Y, Tsuchiya T, Chiba T, Yamaza H.
    • Journal Title

      Neurobiol Aging, 24

      Pages : 117-123

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390128
  • [Journal Article] Hepatic gene expression profile of lipid metabolism in rats : impact of caloric restriction and growth hormone/IGF-1 suppression.

    • Author(s)
      Higami Y, Tsuchiya T, Chiba T, Yamaza H, Muraoka I, Hirose M, Komatsu T, Shimokawa I
    • Journal Title

      J Gerontol A Biol Sci Med Sci (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Hepatic gene expression profile of lipid metabolism in rats : impact of caloric restriction and growth hormone/IGF-1 suppression.

    • Author(s)
      Higami Y, Tsuchiya T, et al.
    • Journal Title

      J Gerontol A Biol Sci Med Sci in press

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Effect of leptin on hypothalamic gene expression in calorie-restricted rats.

    • Author(s)
      Komatsu T, Higami Y, et al.
    • Journal Title

      J Gerontol A Biol Sci Med Sci in press

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Journal Article] Effect of leptin on hypothalamic gene expression in calorie-restricted rats.

    • Author(s)
      Komatsu T, Chiba T, Yamaza H, To K, Toyama H, Higami Y, Isao Shimokawa I
    • Journal Title

      J Gerontol A Biol Sci Med Sci (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590317
  • [Presentation] 新たなカロリー制限の分子メカニズム ~脂肪代謝と脂肪組織のリモデリング~2015

    • Author(s)
      成田匠、沖田直之、須藤結香、樋上賀一
    • Organizer
      老化促進モデルマウス(SAM)研究協議会・第30回研究発表会
    • Place of Presentation
      岐阜市岐阜大学サテライトキャンパス
    • Year and Date
      2015-07-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-26670193
  • [Presentation] カロリー制限時の白色脂肪組織におけるSrebp-1 支配的遺伝子発現変動の網羅的解析2009

    • Author(s)
      仲條 良和、沖田 直之、伊藤 麻希子、鈴木 智典、宮崎 智、樋上 賀一
    • Organizer
      第32回日本基礎老化学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-19590396
  • [Presentation] Caloric restriction upregulates the Akt-Glut pathway in the white adipose tissue possibly through moderate suppression of growth hormone2008

    • Author(s)
      Seongjoon Park, Komatsu T, Yamaza H, Chiba T,Higami Y,Shimokawa I
    • Organizer
      第31回日本基礎老化学会
    • Place of Presentation
      松本
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Presentation] Calorie restriction increases TORC2-dependent CREB activity for induction of gluconeogenetic gene expression by down-regulation of AMPK2008

    • Author(s)
      Lucas S. Trindade, Komatsu T, Yamaza H, Chiba T,Higami Y,Shimokawa I
    • Organizer
      第31回日本基礎老化学会
    • Place of Presentation
      松本
    • Data Source
      KAKENHI-PROJECT-19590227
  • [Presentation] foxO1 is not involved in the calorie restriction - specific response to oxidative stress in mice liver2007

    • Author(s)
      Komatsu T, Fukumoto Y, Mashima H, Furuyama T, Chiba T, Yamaza H, Higami H, Shimokawa I
    • Organizer
      36th Annual Meeting of American Aging Association
    • Place of Presentation
      San Antonio, TX USA
    • Data Source
      KAKENHI-PROJECT-19590227
  • 1.  SHIMOKAWA Isao (70187475)
    # of Collaborated Projects : 13results
    # of Collaborated Products : 26results
  • 2.  OKITA Naoyuki (60453841)
    # of Collaborated Projects : 5results
    # of Collaborated Products : 2results
  • 3.  CHIBA Takuya (40336152)
    # of Collaborated Projects : 4results
    # of Collaborated Products : 17results
  • 4.  TSUCHIYA Tomoshi (30437884)
    # of Collaborated Projects : 4results
    # of Collaborated Products : 1results
  • 5.  NAGAYASU Takeshi (80284686)
    # of Collaborated Projects : 4results
    # of Collaborated Products : 1results
  • 6.  YAMAZA Haruyoshi (30336151)
    # of Collaborated Projects : 3results
    # of Collaborated Products : 25results
  • 7.  AKITA Sadanori (90315250)
    # of Collaborated Projects : 3results
    # of Collaborated Products : 0results
  • 8.  YAMASAKI Naoya (70404217)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 1results
  • 9.  池田 高良 (50034624)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 0results
  • 10.  TAGAWA Tsutomu (20363492)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 11.  SUDO Yuka (70646695)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 1results
  • 12.  小林 英司 (00245044)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 13.  李 桃生 (50379997)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 14.  野口 満 (00325648)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 15.  小林 正樹 (30795612)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 16.  中川 嘉 (80361351)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 17.  柴田 淳史 (30707633)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results

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