Kojima Masaki 小島正樹

… Alternative Names

小島正樹コジママサキ

KOJIMA MASAKI 小島正樹

KOJIMA Masaki 小島正樹

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Researcher Number	90277252
Other IDs
External Links
Affiliation (Current)	2025: 東京薬科大学, 生命科学部, 教授
Affiliation (based on the past Project Information) *help	2023: 東京薬科大学, 生命科学部, 教授 2015: 東京薬科大学, 生命科学部, 教授 2008 – 2011: 東京薬科大学, 生命科学部, 教授 2007: Iwate Medical University, School of Pharmacy, Associate Professor 2006: 東京薬科大学, 生命科学部, 助教授 2005: 東京薬科大学, 生命科学部, 講師 1996 – 2002: Tokyo University of Pharmacy and Life Science, Department of Life Science, Assis, 生命科学部, 助手
Review Section/Research Field	Principal Investigator Physical pharmacy / Biophysics Except Principal Investigator Structural biochemistry / Analytical chemistry / Basic Section 34020:Analytical chemistry-related / Virology / 医薬分子機能学 / 応用微生物学・応用生物化学 / Structural biochemistry / Biological pharmacy
Keywords	Principal Investigator フォールディング / X線溶液散乱 / 変性 / HIVプロテアーゼ / 分子軌道法 / 自由エネルギー摂動法 / 分子動力学法 / シミュレーション / NMR / カルボキシメチル化 / リボヌクレアーゼT_1 … More Except Principal Investigator … More Bacillus brevis / Brugia malayi / Fab / 金属プロテアーゼ / プロテアーゼ / フィラリア / システインプロテアーゼ / アスパラギン酸プロテアーゼ / 融合遺伝子 / グルタチオントランスフェラーゼ / filaria / cDNA / RNAi / Caenorhabditis elegans / 線虫 / Cryptic plasmid / プロガストリン分解プロテアーゼ / トリプシン / ヘプシン / エンテロペプチダーゼ / α-synuclein / 生物物理 / アミロイド / ドパミン / パーキンソン病 / CH1ドメイン / α-アミラーゼ / 分泌 / 単鎖抗体 / シグナルペプチド / 抗体Fab断片 / 触媒機構 / グルタチオン / チオレドキシン / 基質特異性 / X線結晶構造解析 / 部位特異的変異 / 蛋白工学 / スクリーニング法 / レセプター / フッ素化合物 / 横緩和時間 / 核磁気共鳴法 / 標的タンパク質 / リガンド / 分子間相互作用 / 含フッ素化合物 / がん / 抗体 / ヘルペスウイルス / 腫瘍溶解性ウイルス療法 / 遺伝子治療 / intermediate / familial Parkinson's disease / Alzheimer's disease / amyloid fibrils / NACP / 中間体 / α-シヌクレイン / 家族性パーキンソン病 / アルツハイマー病 / アミロイド線維形成 / heterologous expression / cDNA cloning / deubiquitinating enzyme / metalloprotease / cysteine protease / Aspartic protease / 抗体染色 / 組織内分布 / マレー糸状虫 / 異宿主発現 / cDNAクローニング / 脱ユビチキン化プロテアーゼ / マレー系状虫 / parasite / post genome / protease / nematode / 阻害剤 / 寄生虫 / ポストゲノム / Single-chain antibody / Secretion-vector / 分泌生産 / 抗体Fab′断片 / SD配列 / プロモーター / 宿主ベクター系 / eryptic plasmid / cryptic plasmid / 分泌ベクター / Proteinase / Membrane-bound proteinase / Cathepsin E / Colopsin / Hepsin / CAAX-motif-specific proteinase / Progastrin-cleaving proteinase / Brain-gut proteinase / α-キモトリプシン / CAAX-モチーフ特異的プロテアーゼ / セリンプロテアーゼ / 膜結合性プロテアーゼ / カテプシンE遺伝子 / 膜結合プロテアーゼ / カテプシンE / コロプシン / CAAXモチーフ特異的プロテアーゼ / 脳・腸管系プロテアーゼ / Bovine filaria / Human filaria / Base sequence analysis / Cloning / Cryteine proteinase / Aspartic proteinase / cDNA Library / Filarial proteinase / PCR / 塩基配列解析 / カテプシンD / カテプシンS / ガストリックシン / カテプシンロ / フィラリアプロテアーゼ / ウシ・フィラリア / ヒト・フィラリア / 塩基配列決定 / クローニング / システイン・プロテアーゼ / cDNAライブラリー / フィラリア・プロテアーゼ / trypsin / _2-macroglobulin / pepsinogen / hepsin / enteropeptidase / gastric trypsin / VIP-degrading endopeptidase / gastrointestinal proteinase / 蛋白分解 / プロセシング / 細胞内トリプシン / β-アミロイドペプチド / αキモトリプシン / プロリルエンドペプチダーゼ / α_2マクログロブリン / α_2マクログラブリン / ペプシノーゲン / 胃トリプシン / VIP分解エンドペプチダーゼ / 胃・腸管系プロテアーゼ / オリゴマー形成 / アミロイド繊維化 / 分子認識 / 糖鎖 / 酵素反応 / キチナーゼ / 分子動力学計算 / X線溶液散乱 / 蛋白質 / X線構造解析 / タンパク質 / 分析化学 / 生理物理 / 脳神経疾患 / 高分子構造・物性 / オリゴマー中間体 / アミロイド線維 / a-synuclein / 生物学的分析 / 分子動力学 / 静電ポテンシャル / 薬物代謝酵素 / X線結晶解析 / タンパク質立体構造 / 環境汚染物質 / 活性部位残基 / グルタチオンS-トランスフェラーゼ / 脱ハロゲン化 / ハロゲン化炭化水素 Less

Development of the novel NMR screening methods toward the drug discovery of fluorinated compounds
- Principal Investigator
  
  田代充
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 34020:Analytical chemistry-related
- Research Institution
  Meisei University
Development of highly specific oncolytic herpes virus vectors by modification of two envelope glycoproteins
- Principal Investigator
  
  Uchida Hiroaki
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Virology
- Research Institution
  The University of Tokyo
アミロイド化初期段階におけるドパミンによるオリゴマー形式の高精度検出法の開発
- Principal Investigator
  
  田代櫻子
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Analytical chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Elucidation of structure and function relationship in multiple-domain chitinases probed by a combination of X-ray crystallography, solution scattering, and molecular dynamics simulation
- Principal Investigator
  
  NONAKA Takamasa
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  Iwate Medical University
Studies of an early stage amyloid formation for Parkinson`s Disease casual protein.
- Principal Investigator
  
  TASHIRO Sakurako
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Analytical chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Development of high precision method to detect amyloid formation for Alzheimer's disease
- Principal Investigator
  
  TASHIRO Sakurako
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Analytical chemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
フォールディング機構に基づくHIVプロテアーゼの不活性化Principal Investigator
- Principal Investigator
  
  小島正樹
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
バイオターゲティング素子としての抗体断片の高効率生産と構造機能解析
- Principal Investigator
  
  山形秀夫
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo University of Pharmacy and Life Science
バイオターゲティング素子としての抗体断片の高効率生産と構造機能解析
- Principal Investigator
  
  山形秀夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo University of Pharmacy and Life Science
Post-genome study on filarial proteases for development of inhibitors.
- Principal Investigator
  
  HIDESHI Inoue
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo University of Pharmacy and Life Science
Molecular Biological Studies on the Proteases and .Their Inhibifors of Filarial Parasites
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化
- Principal Investigator
  
  井上英史
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo University of Pharmacy and Life Science
バイオターゲッティング素子としての抗体断片の高効率生産と構造機能解析
- Principal Investigator
  
  YAMAGATA Hideo
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo University of Pharmacy and Life Science
チオレドキシン類似インタエレメント酵素群の構造機能相関と分子進化
- Principal Investigator
  
  井上英史
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Pharmacy and Life Science
Structural, Functional and Physiological Characterization of Novel Brain-Gut Proteinases
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
A systematic analysis of the effects of fine-structures of antibodies on microbial expression and secretion and construction of a general-purpose system for antibody production.
- Principal Investigator
  
  YAMAGATA Hideo
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Tokyo University of Pharmacy and Life Science
環境汚染物質の除去を目的としたハロゲン化炭素水素代謝酵素の蛋白工学的研究
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Pharmacy and Life Science
立体構造と蛋白工学的解析に基づくグルタチオン・トランスフェラーゼの機能発現機構
- Principal Investigator
  
  井上英史
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo University of Pharmacy and Life Science
リボヌクレアーゼT_1の構造・機能相関の物理化学的解析Principal Investigator
- Principal Investigator
  
  小島正樹
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Tokyo University of Pharmacy and Life Science
Studies on Filarial Proteinases and Their Inhibitors for Development of Filarial Drugs
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science
Systematic search for novel proteinases in gastrointestinal tract and studies on their physiological roles and structure/function
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo University of Pharmacy and Life Science

All 2010 2008 2007 2005

All Journal Article Presentation

[Journal Article] Structure of full-length class I chitinase from rice revealed by X-ray crystallography and small-angle2010
- Author(s)
  Kezuka, Y., Kojima, M., Mizuno, R., Suzuki, K., Watanabe, T. & Nonaka, T
- Journal Title
  
  X-ray scattering Proteins
  
  Volume: 78 Pages: 2295-2305
- Data Source
  KAKENHI-PROJECT-21570119
[Journal Article] Characterization of Fibrillation Process of α-Synuclein at the initial stage2008
- Author(s)
  Tashiro, M., Kojima, M., Kihara, H., Kasai, K., Kamiyoshihara, T., Ueda, K., Shimotakahara, S
- Journal Title
  
  Biochem Biophys Res Commun 369
  
  Pages: 910-914
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Journal Article] Characterization of Fibrillation Process of a-Synuclein at the initial stage2008
- Author(s)
  Tashiro M, Kojima M, Kihara, H., Kasai, K., Kamiyoshihara T, Ueda K, Shimotakahara S.
- Journal Title
  
  Biochem Biophys Res Commun (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17550085
[Journal Article] Characterization of Fibrillation Process of α-Synuclein at the initial stage2008
- Author(s)
  Tashiro M, Kojima M, Kihara, H., Kasai, K., Kamiyoshihara T, Ueda K, Shimotakahara S.
- Journal Title
  
  Biochem Biophys Res Commun 369
  
  Pages: 910-914
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17550085
[Journal Article] Characterization of fibrillation process of alpha-synuclein at the initial stage.2008
- Author(s)
  Tashiro M, Kojima M, Kihara H, Kasai K, Kamiyoshihara T, Ueda K, Shimotakahara S.
- Journal Title
  
  Biochem Biophys Res Commun. 369(3)
  
  Pages: 910-914
- Data Source
  KAKENHI-PROJECT-20550083
[Journal Article] Observation of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis2007
- Author(s)
  Kamiyoshihara, T., Kojima, M., Ueda, K., Tashiro, M., Shimotakahara, S
- Journal Title
  
  Biochem Biophys Res Commun 355(2)
  
  Pages: 398-403
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Journal Article] Obseration of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis2007
- Author(s)
  Kamiyoshihara T, Kojima M, Ueda K, Tashiro M, Shimotakahara S.
- Journal Title
  
  Biochem Biophys Res Commun 355
  
  Pages: 398-403
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17550085
[Journal Article] Observation of multiple intermediates in alpha-synuclein fibril formation by singular value decomposition analysis2007
- Author(s)
  Kamiyoshihara T, Kojima M, Ueda K, Tashiro M, Shimotakahara S.
- Journal Title
  
  Biochem Biophys Res Commun 355
  
  Pages: 398-403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17550085
[Presentation] パーキンソン病原因タンパク質α-synucleinの初期段階アミロイド形成機構の解明2008
- Author(s)
  笠井恒希,田代充,小島正樹,木原裕,上田健治,上吉原智晃,田代(下高原)櫻子
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20550083
[Presentation] パーキンソン病原因タンパク質a-synucleinの初期段階アミロイド形成機構の解明2008
- Author(s)
  笠井恒希, 田代充, 小島正樹, 木原裕, 上田健治, 上吉原智晃, 田代(下高原)櫻子
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-20550083
[Presentation] パーキンソン病原因タンパク質alpha-synucleinのアミロイド線維形成の解析2007
- Author(s)
  田代充・田代桜子・上吉原智晃・小島正樹・上田健冶
- Organizer
  第68回分析化学討論会
- Place of Presentation
  宇都宮大学峰キャンパス
- Year and Date
  2007-05-19
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Presentation] パーキンソン病原因タンパク質a-synucleinのアミロイド線維形成の解析2007
- Author(s)
  田代櫻子, 上吉原智晃, 小島正樹, 上田健治, 田代充
- Organizer
  日本薬学会第129年会
- Place of Presentation
  富山
- Year and Date
  2007-03-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Presentation] Study of amyloid formation mechanism using alpha-synuclein from Parkinson's disease2007
- Author(s)
  Shimotakahara, Tashiro, S., Kamiyoshihara, T., Kojima, M., Ueda, K., Tashiro, M.
- Organizer
  129th Annual Pharmacy Society Meeting
- Place of Presentation
  Toyama, Japan
- Year and Date
  2007-03-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Presentation] Analysis of amyloid formation mechanism using alpha-synuclein from Parkinson's disease2007
- Author(s)
  Tashiro, M., Shimotakahara, Tashiro, S., Kamiyoshihara, T., Kojima, M., Ueda, K
- Organizer
  68th Analytical Chemistry Forum
- Place of Presentation
  University of Utsunomiya, Japan
- Year and Date
  2007-05-19
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Presentation] パーキンソン病関連タンパク質a-synucleinにおけるアミロイド形成機構の解明2005
- Author(s)
  上吉原智晃, 小島正樹, 宮本怜, 上田健治, 田代充, 神藤季三郎, 下高原桜子
- Organizer
  第28回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2005-12-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17550085
[Presentation] Analysis of amyloid formation mechanism using alpha-synuclein from Parkinson's disease2005
- Author(s)
  Kamiyoshihara, T., Kojima, M., Miyamoto, R., Ueda, K., Tashiro, M., Shindo, H., Shimotkahara, S
- Organizer
  28th Annual Molecular Biology Society Meeting
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2005-12-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17550085

1. INOUE Hideshi (20184765)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. TAKAHASHI Kenji (70011533)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. YAMAGATA Hideo (20023468)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. OHTA Toshihiro (10266893)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. TASHIRO Mitsuru (40315750)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
6. TASHIRO Sakurako (40328555)

# of Collaborated Projects: 3 results

# of Collaborated Products: 15 results
7. NONAKA Takamasa (30242457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. KEZUKA Yuichiro (50397163)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. NISHII Wataru (30287461)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. UDAKA Shigezo (70023463)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Uchida Hiroaki (20401250)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. TAHARA HIDEAKI (70322071)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IWASA Susumu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SENARCTH Dis

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. R.WEERAPPULI ウィーラプリアール

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ATHAUDA Sena

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. ATHOUDA Senarath B.P.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. WINALASIRI Weerappuli R.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. DISSONAYAKE Senarath

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SENARATH Dis

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. WEELAPPULI R

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SENARATH B.P

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. DISSANAYAKE セナラッツ

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. WIMALASIRI W

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. DISSANAYAKE セナラッツ.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kojima Masaki 小島 正樹

小島 正樹 コジマ マサキ

KOJIMA MASAKI 小島 正樹

KOJIMA Masaki 小島 正樹

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フォールディング機構に基づくHIVプロテアーゼの不活性化Principal Investigator

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Kojima Masaki 小島正樹

小島正樹コジママサキ

KOJIMA MASAKI 小島正樹

KOJIMA Masaki 小島正樹