Doyu Manabu 道勇学

… Alternative Names

道勇学ドウユウマナブ

DOYU Manabu 道勇学

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Researcher Number	90293703
Other IDs
External Links
Affiliation (Current)	2025: 愛知医科大学, 医学部, 名誉教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 愛知医科大学, 医学部, 教授 2015 – 2016: 愛知医科大学, 医学部, 教授 2008: 愛知医科大学, 医学部, 教授 2007: 愛知医科大学, 医学部, 特任教授 2006: Aichi Medical University, School of Medicine, Professor, 医学部, 教授 … More 2004 – 2005: Nagoya University, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 2004 – 2005: Nagoya Univesity, Department of Neurology, Assistant Professor, 大学院医学系研究科, 助教授 2002 – 2003: 名古屋大学, 大学院・医学系研究科, 講師 2001: 名古屋大学, 大学院・医学研究科, 教授 2001: Graduate School of Medicine, Nagoya University, Assistant Professor, 大学院・医学研究科, 講師 1998 – 2000: 名古屋大学, 医学部, 講師 1998: 名古屋大学, 医学部・名古屋大学, 講師 Less
Review Section/Research Field	Principal Investigator Neurology / Neurology / Basic Section 52020:Neurology-related Except Principal Investigator Neurology / Biological Sciences / Basic Section 52020:Neurology-related / Basic Section 51030:Pathophysiologic neuroscience-related / Ophthalmology / Neurology
Keywords	Principal Investigator 球脊髄性筋萎縮症 / 筋萎縮性側索硬化症 / アンドロゲン受容体 / p97 / VCP / Dorfin / トランスジェニックマウス / CAGリピート / iPS細胞 / 疾患iPS細胞 … More / 運動ニューロン / spinal and bulbar muscular atrophy / HSP70 / LHRHアナログ / 遺伝子発現解析 / DNA chip / 蛋白分解 / マススペクトロメトリー / 酵母Two-Hybrid / トランスクリプトーム / 骨格筋 / gene expression profiles / LHRH analog / polyglutamine / amyotrophic lateral sclerosis / motor neuron / ユビキチンリガーゼ / ヒストン脱アセチル化 / 分子シャペロン / バイオマーカー / 臨床試験 / ポリグルタミン / protein degradation / LHRH analogue / castration / transgenic mouse / CAG repeat / androgen receptor / Hsp / ホルモン治療 / テストステロン / 去勢術 / Gene expression analysis / In vitro neuronal cell culture model / adenovirus vector / Spinal and bulbar muscular atrophy / neuronal cell death / polyglutamine tract / CAG repeat disease / ポリグルタミン凝集体 / 培養神経系細胞モデル / アデノウイルスベクター / 神経細胞死 / ポリグルタミン鎖 / CAGリピート病 / Ubiquitination / IBR Motif / Ring Finger / Novel Genes / Motor Neuron Death / Expressed-Gene Profile / Molecular Indexing / Amyotrophic Lateral Screlosis / 神経悪性疾患 / 運動ニューロン疾患 / ユビキチン系 / リングフィンガーモチーフ / 新規遺伝子 / 運動ニューロン死 / 遺伝子発現プロファイル / 分子インデックス法 / GGA / Hsp70 / Hsp90阻害剤 / アルツハイマー病 / パーキンソン病 / MAP1B / 微小管結合蛋白 … More Except Principal Investigator 運動ニューロン / ポリグルタミン / ALS / アンドロゲン受容体 / 球脊髄性筋萎縮症 / heat shock protein / motor neuron / geranylgeranylaceone / 遺伝子発現解析 / dynactin1 / GGA / 17-AAG / HSP / 筋萎縮性側索硬化症 / siRNA / IP-10 / RANTES / MIP-1β / MCP-1 / Th2 / Th1 / chemokine receptor / chemokine / histone / polyglutamine / テストステロン / 熱ショックタンパク質 / ヒストン / LHRHアナログ / 神経変性 / CAGリピート / 分子シャペロン / ユビキチン-プロテアソーム / 軸索輸送 / 球脊髄性筋萎縮症(SBMA) / cDNAマイクロアレー / レーザーマイクロダイセクション法 / missing heritability / ACSL5 / リピート伸長変異 / missing heritabbility / 次世代シークエンサー / 構造多型 / LRP1 / THSD7A / FGF1 / 疾患レジストリ / 神経病理解析 / 線維芽細胞 / 外眼筋周囲脂肪組織 / 平滑筋細胞 / 脱分化 / 筋線維芽細胞 / 平滑筋線維 / 甲状腺眼症 / autophagy / gene expression analysis / cDNAマイクロアレイ / オートファジー / biomarker / ubiquitin-proteasome / molecular chaperone / spinal and bulbar muscular atrophy / 神経変性疾患 / バイオマーカー / androgen receptor / Neurodegeneration / フルタミド / Inflammatory myopathy / 封入体筋炎 / 皮膚筋炎 / 多発筋炎 / 炎症性筋疾患 / LHRH analog / andorogen receptor / neurodegeneration / アンドロゲン受容体(AR) / DNA chip / 培養神経系細胞モデル / アデノウイルスベクター / 神経細胞死 / ポリグルタミン鎖 / CAGリピート病 / Hsp / ホルモン治療 / びまん性核内蓄積 / HSP70 / 去勢術 / トランスジェニックマウス / アロドロゲン受容体 / dynactinl / 疾患モデル / 線虫 / cyclin C / 熱ショック蛋白質 / ユビキチン・プロテアソーム / リュープロレリン / ユビキチンープロテアソーム / 神経分子病態学 / ニューロフィラメント / dnactin1 / モーター蛋白質 / CHIP / ポリグルタミン病 / 17-DMAG / プロテアソーム / ユビキチン / TGF-β / 転写障害 / 脊髄小脳失調症(SCA) / 発現遺伝子プロファイル / 筋萎縮性側索硬化症(ALS) / 運動ニューロン疾患 / クローニング / 遺伝子発現 / 病態関連遺伝子 / 分子インデックス法 / パーキンソン病 Less

Establishment of efficient pathological analysis and drug discovery platform for amyotrophic lateral sclerosis using disease specific iPSCsPrincipal Investigator
- Principal Investigator
  
  道勇学
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Aichi Medical University
Elucidating the heterogeneity of amyotrophic lateral sclerosis by neuropathological analysis linked to clinical genomic information
- Principal Investigator
  
  熱田直樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Aichi Medical University
筋萎縮性側索硬化症のmissing heritabilityに関わる遺伝子の探索
- Principal Investigator
  
  中村亮一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Aichi Medical University
Elucidaion of muscular pathology of SBMA using disease specific iPSCsPrincipal Investigator
- Principal Investigator
  
  Doyu Manabu
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Aichi Medical University
甲状腺眼症における筋線維芽細胞の起源の研究
- Principal Investigator
  
  柿崎裕彦
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Aichi Medical University
Pathogenesis-based therapy development for polyglutamine diseases
- Principal Investigator
  
  SOBUE Gen
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Development of animal model for sporadic ALS
- Principal Investigator
  
  TANAKA Fumiaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Development of pathogenesis-based therapy for polyglutamine diseases
- Principal Investigator
  
  SOBUE Gen
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
分子シャペロンによる運動ニューロン疾患治療法の開発-SBMA・ALSを中心に-Principal Investigator
- Principal Investigator
  
  道勇学
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Treatment of polyglutamine disease using small molecular compound
- Principal Investigator
  
  SOBUE Gen
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Exploration of Target Molecules Related to Pathogenesis and Development of Therapy for Sporadic ALS
- Principal Investigator
  
  TANAKA Fumiaki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
ユビキチンリガーゼDorfinの基質タンパク質の探索-神経変性との関連Principal Investigator
- Principal Investigator
  
  道勇学
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Development of low-molecular-weight compound therapy for polyglutamine diseasesPrincipal Investigator
- Principal Investigator
  
  DOYU Manabu
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
孤発性ALSにおけるユビキチンリガーゼDorfinの基質タンパク質の探索Principal Investigator
- Principal Investigator
  
  道勇学
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Development of Pathogenesis-based treatment for spinal and bulbar muscular atrophy
- Principal Investigator
  
  SOBUE Gen
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
Investigation into pathology of CAG repeat diseases and development of therapiesPrincipal Investigator
- Principal Investigator
  
  DOYU Manabu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
investigation of pathomechanism of inflammatory myopathy (in view of chemokines)
- Principal Investigator
  
  INUKAI Akira
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  NAGOYA UNIVERSITY
運動ニューロン疾患の神経細胞死に係わる分子群の同定
- Principal Investigator
  
  祖父江元
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagoya University
Elucidation of molecular mechanism of neuronal cell death in spinal and bulbar muscular atrophy
- Principal Investigator
  
  SOBUE Gen
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya University
Elucidation of pathogenesis in CAG-repeat diseases using DNA chipPrincipal Investigator
- Principal Investigator
  
  DOYU Manabu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University
遺伝子発現プロファイリングによるパーキンソン病の病態関連遺伝子の同定
- Principal Investigator
  
  SOBUE Gen
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagoya University
Detection of Relating Molecules for the Pathology of Amyotrophic Lateral Screlosis by the Expressed-Gene ProfilingPrincipal Investigator
- Principal Investigator
  
  DOYU Manabu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Nagoya University

All 2023 2022 2021 2020 2019 2010 2009 2007 2006 2005 2004 2003 2001

All Journal Article Presentation

[Journal Article] Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling2023
- Author(s)
  Rashid Muhammad Irfanur、Ito Takuji、Miya Fuyuki、Shimojo Daisuke、Arimoto Kanae、Onodera Kazunari、Okada Rina、Nagashima Takunori、Yamamoto Kazuki、Khatun Zohora、Shimul Rayhanul Islam、Niwa Jun-ichi、Katsuno Masahisa、Sobue Gen、Okano Hideyuki、Sakurai Hidetoshi、Shimizu Kazunori、Doyu Manabu、Okada Yohei
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 8146-8146
- DOI
  10.1038/s41598-023-34445-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15739, KAKENHI-PROJECT-22KJ2982, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-23K06955, KAKENHI-PROJECT-23K06975, KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-23H00420, KAKENHI-PROJECT-23K24249
[Journal Article] Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients2023
- Author(s)
  Nakamura R, Tohnai G, Nakatochi M,… Onodera K, Ito T, Okada Y, Okano H, Sobue G
- Journal Title
  
  Journal of Neurology, Neurosurgery & Psychiatry
  
  Volume: 94 Issue: 10 Pages: 816-824
- DOI
  10.1136/jnnp-2022-330851
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15739, KAKENHI-PROJECT-19K06523, KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-22K07359, KAKENHI-PROJECT-22K07509, KAKENHI-PROJECT-23K06955, KAKENHI-PROJECT-23K06975, KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-23K24249
[Journal Article] An Exploratory Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS): Protocol for a Multicenter, Open-Labeled, 24-Week, Single-Group Study.2023
- Author(s)
  Haji S, Fujita K, Oki R, Osaki Y, Miyamoto R, Morino H, Nagano S, Atsuta N, Kanazawa Y, Matsumoto Y, Arisawa A, Kawai H, Sato Y, Sakaguchi S, Yagi K, Hamatani T, Kagimura T, Yanagawa H, Mochizuki H, Doyu M, Sobue G, Harada M, Izumi Y.
- Journal Title
  
  JMIR Res Protoc.
  
  Volume: 12 Pages: e42032-e42032
- DOI
  10.2196/42032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07359, KAKENHI-PROJECT-23K18265, KAKENHI-PROJECT-23K06975, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-21H02841, KAKENHI-PUBLICLY-22H04811
[Journal Article] Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson's disease.2021
- Author(s)
  Taguchi S, Koide H, Oiwa H, Hayashi M, Ogawa K, Ito C, Nakashima K, Yuasa T, Yasumoto A, Ando H, Fujikake A, Fukuoka T, Tokui K, Izumi M, Tsunoda Y, Kawagashira Y, Okada Y, Niwa JI, Doyu M.
- Journal Title
  
  PLoS One.
  
  Volume: 16 Issue: 7 Pages: e0255274-e0255274
- DOI
  10.1371/journal.pone.0255274
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-19K17247, KAKENHI-PROJECT-19H03576
[Journal Article] Modulation of oxygen tension, acidosis, and cell density is crucial for neural differentiation of human induced pluripotent stem cells.2020
- Author(s)
  Okada R, Onodera K, Ito T, Doyu M, Okano HJ, Okada Y
- Journal Title
  
  Neurosci. Res.
  
  Volume: - Pages: 30043-2
- DOI
  10.1016/j.neures.2020.01.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-18K15470, KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-19H03576, KAKENHI-PROJECT-19J40240
[Journal Article] Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs2020
- Author(s)
  Onodera K, Shimojo D, Ishihara Y, Yano M, Miya F, Banno H, Kuzumaki N, Ito T, Okada R, Ohyama M, Yoshida M, Tsunoda T, Katsuno M, Doyu M, Sobue G, Okano H, Okada Y
- Journal Title
  
  Mol. Brain
  
  Volume: 13 Issue: 1 Pages: 18-18
- DOI
  10.1186/s13041-020-0561-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-17H04195, KAKENHI-PROJECT-19H03576, KAKENHI-PROJECT-18K15470, KAKENHI-PROJECT-20K16587, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-19J40240
[Journal Article] Motor Improvement-Related Regional Cerebral Blood Flow Changes in Parkinson's Disease in Response to Antiparkinsonian Drugs.2019
- Author(s)
  Taguchi S, Tanabe N, Niwa JI, Doyu M.
- Journal Title
  
  Parkinsons Dis.
  
  Volume: 0 Pages: 7503230-7503230
- Data Source
  KAKENHI-PROJECT-19K07969
[Journal Article] Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis.2010
- Author(s)
  Sone J, Niwa JI, Kawai K, Ishigaki S, Yamada SI, Adachi H, Katsuno M, Tanaka F, Doyu M, Sobue G.
- Journal Title
  
  J Neurosci Res. 88
  
  Pages: 123-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy2009
- Author(s)
  Banno, H., Katsuno, M., Suzuki, K., Takeuchi, Y., Kawashima, M., Suga, N., Takamori, M., Ito, M., Nakamura, T., Matsuo, K., Yamada, S., Oki, Y., Adachi, H., Minamiyama, M., Waza, M., Atsuta, N., Watanabe, H., Fujimoto, Y., Nakashima, T., Tanaka, F., Doyu, M., Sobue, G.
- Journal Title
  
  Ann Neurol 65
  
  Pages: 140-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy2009
- Author(s)
  Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Suga N, Takamori M, Ito M, Nakamura T, Matsuo K, Yamada S, Oki Y, Adachi H, Minamiyama M, Waza M, Atsuta N, Watanabe H, Fujimoto Y, Nakashima T, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Ann. Neurol 65
  
  Pages: 140-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy2009
- Author(s)
  Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Suga N, Takamori M, Ito M, Nakamura T, Matsuo K, Yamada S, Oki Y, Adachi H, Minamiyama M, Waza M, Atsuta N, Watanabe H, Fujimoto Y, Nakashima T, Tanaka F, Doyu M, Sobue G.
- Journal Title
  
  Ann Neurol. 65
  
  Pages: 140-150
- Data Source
  KAKENHI-PROJECT-19390238
[Journal Article] Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity2007
- Author(s)
  Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G.
- Journal Title
  
  Neurobiol Dis 25
  
  Pages: 331-341
- Data Source
  KAKENHI-PROJECT-19390238
[Journal Article] Nonmyelinating Schwann cell involvement with well-preserved unmyelinated axons in Charco-Matie-Tooth disease type 1A2007
- Author(s)
  Koike H, Iijima M, Mori K, Yamamoto M, Hattori N, Katsuno M, Tanaka F, Watanabe H, Doyu M, Yoshikawa H, Sobue G
- Journal Title
  
  J Neuropathol Exp Neurol 66
  
  Pages: 1027-1036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model2007
- Author(s)
  Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G.
- Journal Title
  
  J Neurosci 27
  
  Pages: 5115-5126
- Data Source
  KAKENHI-PROJECT-19390238
[Journal Article] CHIP Overexpression Reduces Mutant Androgen Receptor Protein and Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model2007
- Author(s)
  Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J. Neurosci 27
  
  Pages: 5115-5126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy2007
- Author(s)
  Adachi H, Waza M, Katsuno M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Neuropathol Appl Neurobiol 33
  
  Pages: 135-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy2007
- Author(s)
  Adachi H, Waza M, Katsuno M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Neuropathol Appl Neurobiol 33
  
  Pages: 135-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity.2007
- Author(s)
  Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G
- Journal Title
  
  Neurobiol of Dis 25
  
  Pages: 331-341
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD12007
- Author(s)
  Niwa J, Yamada S, Ishigaki S, Sone J, Takahashi M, Katsuno M, Tanaka F, Doyu M, Sobue G.
- Journal Title
  
  J Biol Chem 282
  
  Pages: 28087-28095
- Data Source
  KAKENHI-PROJECT-19390238
[Journal Article] Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD12007
- Author(s)
  Niwa J, Yamada S, Ishigaki S, Sone J, Takahashi M, Katsuno M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Biol Chem 282
  
  Pages: 28087-28095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Reduces Mutant Androgen Receptor protein and Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model2007
- Author(s)
  Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanak F, Doyu M, Sobue G
- Journal Title
  
  J Neurosci 27
  
  Pages: 5115-5126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, Acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to athologic markers in sporadic amyotrophic lateral sclerosis2007
- Author(s)
  Jiang Y, Yamamoto M, Tanaka F, Ishigaki S, Katsuno M, Adachi H, Niwia J, Doyu M, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Neuropathol Exp Neurol 66
  
  Pages: 617-627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD12007
- Author(s)
  Niwa J, Yamada S, Ishigaki S, Sone J, Takahashi M, Katsuno M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Biol Chem 282
  
  Pages: 28087-28095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Gene expressions specifically detected in motor neurons (dynactin l, early growth response 3, Acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to athologic markers in sporadic amyotrophic lateral sclerosis2007
- Author(s)
  Jiang Y, Yamamoto M, Tanaka F, Ishigaki S, Katsuno M, Adachi H, Niwia J, Doyu M, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Neuropathol Exp Neurol 66
  
  Pages: 617-627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy2007
- Author(s)
  Adachi H, Waza M, Katsuno M, Tanaka F, Doyu M, Sobue G.
- Journal Title
  
  Neuropathol Appl Neurobiol 33
  
  Pages: 135-151
- Data Source
  KAKENHI-PROJECT-19390238
[Journal Article] Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity2007
- Author(s)
  Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G
- Journal Title
  
  Neurobiol of Dis 25
  
  Pages: 331-341
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SODI proteins and reduce their cellular toxicity2007
- Author(s)
  Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G
- Journal Title
  
  Neurobiol Dis 25
  
  Pages: 331-241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity2007
- Author(s)
  Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G
- Journal Title
  
  Neurobiol of Dis 25
  
  Pages: 331-341
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Nonmyelinating Schwann cell involvement with well-preserved unmyelinated axons in Charco-Matie-Tooth disease type 1A2007
- Author(s)
  Koike H, Iijima M, Mori K, Yamamoto M, Hattori N, Katsuno M, Tanaka F, Watanabe H, Doyu M, Yoshikawa H, Sobue G
- Journal Title
  
  J Neuropathol Exp Neurol 66
  
  Pages: 1027-1036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SODI proteins and reduce their cellular toxicity2007
- Author(s)
  Ishigaki S, Niwa J, Yamada S, Takahashi M, Ito T, Sone J, Doyu M, Urano F, Sobue G
- Journal Title
  
  Neurobiol Dis 25
  
  Pages: 331-241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model2007
- Author(s)
  Adachi, H., Waza, M., Tokui, K., Katsuno, M., Minamiyama, M., Tanaka, F., Doyu, M., Sobue, G.
- Journal Title
  
  J. Neurosci 27
  
  Pages: 5115-5126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy2007
- Author(s)
  Adachi H, Waza M, Katsuno M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Neuropathol. Appl. Neurobiol 33
  
  Pages: 135-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Reduces Mutant Androgen Receptor Protein and Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model2007
- Author(s)
  Adachi H, Waza M, Tokui K, Katsuno M, Minamiyama M, Tanak F, Doyu M, Sobue G
- Journal Title
  
  J Neurosci 27
  
  Pages: 5115-5126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209033
[Journal Article] Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to pathologic markers in sporadic amyotrophic lateral sclerosis2007
- Author(s)
  Jiang YM, Yamamoto M, Tanaka F, Ishigaki S, Katsuno M, Adachi H, Niwa J, Doyu M, Yoshida M, Hashizume Y, Sobue G.
- Journal Title
  
  J Neuropathol Exp Neurol 66
  
  Pages: 617-627
- Data Source
  KAKENHI-PROJECT-19390238
[Journal Article] Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA).2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol in press
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Modulation of Hsp90 function in neurodegenerative disorders : amolecular-targeted therapy against disease-causing protein2006
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Mol Med 84
  
  Pages: 635-646
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Modulation of Hsp90 function in neurodegenerative disorders : a molecular targeted therapy against disease-causing protein.2006
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Mol Med (in press)
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Gene expression profiling toward understanding of ALS pathogenesis2006
- Author(s)
  Tanaka F, Niwa J, Ishigaki S, Katsuno M, Waza M, Yamamoto M, Doyu M, Sobue G
- Journal Title
  
  Ann N Y Acad Sci 1086
  
  Pages: 1-10
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Modulation of Hsp90 function in neurodegenerative disorders : a molecular-targeted therapy against disease-causing protein2006
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Mol Med 84
  
  Pages: 635-646
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Pathogenesis, animal models and therapeutics in Spinal and bulbar muscular atrophy (SBMA).2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol 200
  
  Pages: 8-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Gene expression profiling toward understanding of ALS pathogenesis2006
- Author(s)
  Tanaka F, Niwa J, Ishigaki S, Katsuno M, Waza M, Yamamoto M, Doyu M, Sobue G
- Journal Title
  
  Ann N Y Acad Sci 1086
  
  Pages: 1-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA).2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol (in press)
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Modulation of Hsp90 function in neurodegenerative disorders : a molecular-targeted therapy against disease-causing protein.2006
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Mol Med 84
  
  Pages: 635-646
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Modulation of Hsp90 function in neurodegenerative disorders : a molecular-targeted therapy against disease-causing protein2006
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Mol Med 84
  
  Pages: 635-646
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA).2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration2006
- Author(s)
  Katsuno M, Adachi H, Minamiyama M, Waza M, Tokui K, Banno H, Suzuki K, Onoda Y, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Neurosci 26
  
  Pages: 12106-12117
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells.2006
- Author(s)
  Yamada S, Niwa J, Ishigaki S, Takahashi M, Ito T, Sone J, Doyu M, Sobue G
- Journal Title
  
  J Biol Chem 281
  
  Pages: 23842-23851
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin : A pathogenic marker2006
- Author(s)
  Banno H, Adachi H, Katsuno M, Suzuki K, Atsuta N, Watanabe H, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Ann Neurol 59
  
  Pages: 520-526
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin : A pathogenic marker.2006
- Author(s)
  Banno H, Adachi H, Katsuno M, Suzuki K, Atsuta N, Watanabe H, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Ann Neurol 59
  
  Pages: 520-526
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Pathogenesis, animal models and therapeutics in spinal and bulbar muscular atrophy (SBMA).2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol (in press)
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Modulation of Hsp90 function in neurodegenerative disorders : a molecular targeted therapy against disease-causing protein.2006
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Mol Med (in press)
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin : A pathogenic marker.2006
- Author(s)
  Banno H, Adachi H, Katsuno M, Suzuki K, Atsuta N, Watanabe H, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Ann Neurol 59
  
  Pages: 520-526
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Pathogenesis, animal models and therapeutics in Spinal and bulbar muscular atrophy (SBMA)2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol 200
  
  Pages: 8-18
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration2006
- Author(s)
  Katsuno M, Adachi H, Minamiyama M, Waza M, Tokui K, Banno H, Suzuki K, Onoda Y, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Neurosci 26
  
  Pages: 12106-12117
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Gene expression profiling toward understanding of ALS pathogenesis2006
- Author(s)
  Tanaka F, Niwa J, Ishigaki S, Katsuno M, Waza M, Yamamoto M, Doyu M, Sobue G
- Journal Title
  
  Ann NY Acad Sci 1086
  
  Pages: 1-10
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells2006
- Author(s)
  Yamada S, Niwa J, Ishigaki S, Takahashi M, Ito T, Sone J, Doyu M, Sobue G
- Journal Title
  
  J Biol Chem 281
  
  Pages: 23842-23851
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin : A pathogenic marker.2006
- Author(s)
  Banno H, Adachi H, Katsuno M, Suzuki K, Atsuta N, Watanabe H, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Ann Neurol 59
  
  Pages: 520-526
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Gene expression profiling toward understanding of ALS pathogenesis.2006
- Author(s)
  Tanaka F, Niwa J, Ishigaki S, Katsuno M, Waza M, Yamamoto M, Doyu M, Sobue G
- Journal Title
  
  Ann NY Acad Sci 1086
  
  Pages: 1-10
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration.2006
- Author(s)
  Katsuno M, Adachi H, Minamiyama M, Waza M, Tokui K, Banno H, Suzuki K, Onoda Y, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Neurosci 26
  
  Pages: 12106-12117
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Pathogenesis, animal models and therapeutics in Spinal and bulbar muscular atrophy (SBMA)2006
- Author(s)
  Katsuno M, Adachi H, Waza M, Banno H, Suzuki K, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Exp Neurol 200
  
  Pages: 8-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells2006
- Author(s)
  Yamada S, Niwa J, Ishigaki S, Takahashi M, Ito T, Sone J, Doyu M, Sobue G
- Journal Title
  
  J Biol Chem 281
  
  Pages: 23842-23851
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin : A pathogenic marker2006
- Author(s)
  Banno H, Adachi H, Katsuno M, Suzuki K, Atsuta N, Watanabe H, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Ann Neurol 59
  
  Pages: 520-526
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients.2005
- Author(s)
  Adachi H, Katsuno M, Minamiyama M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Brain 128
  
  Pages: 659-670
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.2005
- Author(s)
  Katsuno M, Sang C, Adachi H, Minamiyama M, Waza M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Proc Natl Acad Sci USA 102
  
  Pages: 16801-16806
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Widespread nuclear and cytoplasmic mutant androgen receptor accumulation in spinal and bulbar muscular atrophy.2005
- Author(s)
  Adachi H, Katsuno M, Minamiyama M, Waza M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Brain 128
  
  Pages: 659-670
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration.2005
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F, Inukai A, Doyu M, Sobue G
- Journal Title
  
  Nature Med 11
  
  Pages: 1088-1095
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.2005
- Author(s)
  Katsuno M, Sang C, Adachi H, Minamiyama M, Waza M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Proc Natl Acad Sci Usa 102
  
  Pages: 16801-16806
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Gene expression profile of motor neurons in sporadic amyotrophic lateral sclerosis.2005
- Author(s)
  Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu M, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Ann Neurol 57
  
  Pages: 236-251
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Widespread nuclear and cytoplasmic mutant androgen receptor accumulation in spinal and bulbar muscular atrophy.2005
- Author(s)
  Adachi H, Katsuno M, Minamiyama M, Waza M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Brain 128
  
  Pages: 659-670
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.2005
- Author(s)
  Katsuno M, Sang C, Adachi H, Minamiyama M, Waza M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Proc Natl Acad Sci USA 102
  
  Pages: 16801-16806
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Widespread nuclear and cytoplasmic mutant androgen receptor accum ulation in spinal and bulbar muscular atrophy.2005
- Author(s)
  Adachi H, Katsuno M, Minamiyama M, Waza M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Brain 128
  
  Pages: 659-670
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Gene expression profile of motor neurons in sporadic amyotrophic lateral sclerosis.2005
- Author(s)
  Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu M, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Ann Neurol 57
  
  Pages: 236-251
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration2005
- Author(s)
  Waza, M., Adachi, H., Katsuno, M., Minamiyama, M., Sang, C., Tanaka, F., Inukai, A., Doyu, M., Sobue, G.
- Journal Title
  
  Nat. Med. 11
  
  Pages: 1088-1095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration.2005
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F, Inukai A, Doyu M, Sobue G
- Journal Title
  
  Nature Med 11
  
  Pages: 1088-1095
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease2005
- Author(s)
  Katsuno, M., Sang, C., Adachi, H., Minamiyama, M., Waza, M., Tanaka, F., Doyu, M., Sobue, G.
- Journal Title
  
  Proc. Natl. Acad. Sci. U.S.A. 102
  
  Pages: 16801-16806
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease.2005
- Author(s)
  Katsuno M, Sang C, Adachi H, Minamiyama M, Waza M, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  Proc Natl Acad Sci USA 102
  
  Pages: 16801-16806
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration.2005
- Author(s)
  Waza M, Adachi H, Katsuno M, Minamiyama M, Sang C, Tanaka F, Inukai A, Doyu M, Sobue G
- Journal Title
  
  Nature Med 11
  
  Pages: 1088-1095
- Data Source
  KAKENHI-PROJECT-17209032
[Journal Article] Gene expression profile of motor neurons in sporadic amyotrophic lateral sclerosis.2005
- Author(s)
  Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu M, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Ann Neurol 57
  
  Pages: 236-251
- Data Source
  KAKENHI-PROJECT-17025020
[Journal Article] Gene expression profile of motor neurons in sporadic amyotrophic lateral sclerosis.2005
- Author(s)
  Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu M, Yoshida M, Hashizume Y, Sobue G
- Journal Title
  
  Ann Neurol 57
  
  Pages: 236-251
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis.2004
- Author(s)
  Takeuchi H, Niwa J, Hishikawa N, Ishigaki S, Tanaka F, Doyu M, Sobue G.
- Journal Title
  
  J Neurochem. 89
  
  Pages: 64-72
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy.2004
- Author(s)
  Minamiyama M, Katsuno M, Adachi H, Waza M, Sang C, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Sobue G.
- Journal Title
  
  Hum Mol Genet 13
  
  Pages: 1183-1192
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Dorfin prevents cell death by reducing mitochondrial localising mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis.2004
- Author(s)
  Takeuchi H, Niwa J, Hishikawa N, Ishigaki S, Tanaka F, Doyu M, Sobue G
- Journal Title
  
  J Neurochem 89
  
  Pages: 64-72
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy.2004
- Author(s)
  Minamiyama M, Katsuno M, Adachi H, Waza M, Sang C, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Sobue G
- Journal Title
  
  Hum Mol Genet 13
  
  Pages: 1183-1192
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy.2004
- Author(s)
  Minamiyama M, Katsuno M, Adachi H, Waza M, Sang C, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Sobue G
- Journal Title
  
  Hum Mol Genet 13
  
  Pages: 1183-1192
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390250
[Journal Article] Dorfin localizes to the ubiquitilated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis.2003
- Author(s)
  Hishikawa N, Niwa J, Doyu M, Ito T, Ishigaki S, Hashizume Y, Sobue G
- Journal Title
  
  Am J Pathol 163(2)
  
  Pages: 609-619
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Caspase-1 and -3 are differentially upregulated in motor neurons and glial cells in mutant SOD1 transgenic mouse spinal cord : a study usign laser microdissection and real time RT-PCR.2003
- Author(s)
  Ando Y, Liang Y, Ishigaki S, Niwa J, Jiang Y, Kobayashi Y, Yamamoto M, Doyu M, Sobue G
- Journal Title
  
  Neurochem Res 28
  
  Pages: 839-846
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1.2003
- Author(s)
  Ito T, Niwa J, Hishikawa N, Ishigaki S, Doyu M, Sobue G
- Journal Title
  
  J Biol Chem 278(31)
  
  Pages: 29106-29114
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Leuprorelin rescue polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy.2003
- Author(s)
  Katsuno M, Adachi H, Doyu M, Minamiyama M, Sang C, Kobayashi Y, Inukai A, Sobue G
- Journal Title
  
  Nature Medicine 9(6)
  
  Pages: 768-773
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein.2003
- Author(s)
  Adachi H, Katsuno M, Minamiyama M, Sang C, Pagoulatous G, Angelidis C, Kusakabe M, Yoshiki A, Kobayashi Y, Doyu M, Sobue G
- Journal Title
  
  J Neurosci 23(6)
  
  Pages: 2203-2211
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15209031
[Journal Article] Gene expression profile in Alzheimer's brain screened by molecular indexing.2001
- Author(s)
  Doyu M
- Journal Title
  
  Brain Res, Mol Brain Res 87
  
  Pages: 1-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12210010
[Journal Article] Gene expression profile in Alzheimer's brain screened by molecular indexing.2001
- Author(s)
  Doyu M
- Journal Title
  
  Mol Brain Res 87
  
  Pages: 1-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12210010
[Presentation] Phase 3B extension study evaluating superiority of daily vs approved on/off oral edaravone dosing in patients with amyotrophic lateral sclerosis2023
- Author(s)
  Rothstein J, Desilva S, Zinman L, Chum M, Chio A, Ludolph AC, Sobue G, Doyu M, Selness D, Todorovic V, Hirai M, Takahashi F, Wamil A, Salah A, Apple S
- Organizer
  26th World Congress of Neurology (WCN)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06975
[Presentation] Phase 3B study evaluating superiority of daily dosing vs approved on/off oral edaravone dosing over 48 weeks in patients with amyotrophic lateral sclerosis (MT-1186-A02)2023
- Author(s)
  Salah A, Desilva S, Zinman L, Chum M, Chio A, Ludolph AC, Sobue G, Doyu M, Selness D, Todorovic V, Hirai M Wamil A, Apple S
- Organizer
  26th World Congress of Neurology (WCN)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06975
[Presentation] Phase 3B extension study evaluating superiority of daily vs approved on/off oral edaravone dosing in patients with amyotrophic lateral sclerosis2023
- Author(s)
  Rothstein J, Desilva S, Zinman L, Chum M, Chio A, Ludolph AC, Sobue G, Doyu M, Selness D, Todorovic V, Hirai M, Takahashi F, Wamil A, Salah A, Apple S
- Organizer
  26th World Congress of Neurology (WCN)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Phase 3b extension study to evaluate the efficacy and safety of 2 dosing regimens of oral edaravone in patients with amyotrophic lateral sclerosis2023
- Author(s)
  Rothstein J, De Silva S, Zinman L, Chum M, Chio A, Ludolph AC, Sobue G, Doyu M, Selness D, Todorovic V, Hirai M, Takahashi F, Sakata T, Wamil A, Salah A, Apple S
- Organizer
  148th Annual Meeting American-Neurological-Association (ANA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06975
[Presentation] Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients2023
- Author(s)
  Nakamura R, Tohnai G, Nakatochi M, Niwa JI, Doyu M, Fujimori K, Morimoto S, Okada Y, Okano H, Sobue G et al.,
- Organizer
  34th international symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Phase 3B extension study evaluating superiority of daily vs approved on/off oral edaravone dosing in patients with amyotrophic lateral sclerosis2023
- Author(s)
  Rothstein J, Desilva S, Zinman L, Chum M, Chio A, Ludolph AC, Sobue G, Doyu M, Selness D, Todorovic V, Hirai M, Takahashi F, Wamil A, Salah A, Apple S
- Organizer
  22nd Annual Meeting of the Northeast Amyotrophic Lateral Sclerosis Consortium (NEALS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06975
[Presentation] ALSの早期診断・遺伝子診断2023
- Author(s)
  中村亮一、熱田直樹，藤内玄規，丹羽淳一，道勇学，祖父江元
- Organizer
  第64回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Phase 3B extension study evaluating superiority of daily vs approved on/off oral edaravone dosing in patients with amyotrophic lateral sclerosis2023
- Author(s)
  Rothstein J, Desilva S, Zinman L, Chum M, Chio A, Ludolph AC, Sobue G, Doyu M, Selness D, Todorovic V, Hirai M, Takahashi F, Wamil A, Salah A, Apple S
- Organizer
  22nd Annual Meeting of the Northeast Amyotrophic Lateral Sclerosis Consortium (NEALS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2023
- Author(s)
  Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] ALSの早期診断：遺伝子診断2023
- Author(s)
  中村亮一、熱田直樹、藤内玄規、丹羽淳一、道勇学、祖父江元
- Organizer
  第64回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07509
[Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2023
- Author(s)
  小野寺一成, 下門大祐, 石原康晴, 太田明伸, 宮冬樹, Rashid Muhammad Irfanur, 伊藤卓治, 岡田梨奈, 細川好孝, 道勇学, 祖父江元, 勝野雅央, 岡野栄之, 岡田洋平
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients2023
- Author(s)
  Nakamura R, Tohnai G, Nakatochi M, Atsuta N, Ito D, Katsuno M, …Niwa JI, Doyu M, Fujimori K, Morimoto S, Okada Y, Okano H, Sobue G
- Organizer
  34th international symposium on ALS/MND
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06975
[Presentation] Exploration of pathogenic molecules in motor neuron disease using the human ipsc-derived neuromuscular model2023
- Author(s)
  Ito T, Rashid MI, Onodera K, Okada R, Shimojo D, Tanaka S, Katsuno M, Sobue G, Doyu M, Okano H, Okada Y
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Phase 3B study evaluating superiority of daily dosing vs approved on/off oral edaravone dosing over 48 weeks in patients with amyotrophic lateral sclerosis (MT-1186-A02)2023
- Author(s)
  Salah A, Desilva S, Zinman L, Chum M, Chio A, Ludolph AC, Sobue G, Doyu M, Selness D, Todorovic V, Hirai M Wamil A, Apple S
- Organizer
  26th World Congress of Neurology (WCN)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2023
- Author(s)
  小野寺一成, 下門大祐, 石原康晴, 太田明伸, 宮冬樹, Rashid Muhammad Irfanur, 伊藤卓治, 岡田梨奈, 細川好孝, 道勇学, 祖父江元, 勝野雅央, 岡野栄之, 岡田洋平
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23K06975
[Presentation] Phase 3b extension study to evaluate the efficacy and safety of 2 dosing regimens of oral edaravone in patients with amyotrophic lateral sclerosis2023
- Author(s)
  Rothstein J, De Silva S, Zinman L, Chum M, Chio A, Ludolph AC, Sobue G, Doyu M, Selness D, Todorovic V, Hirai M, Takahashi F, Sakata T, Wamil A, Salah A, Apple S
- Organizer
  148th Annual Meeting American-Neurological-Association (ANA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] 筋萎縮性側索硬化症（ALS）新規治療基軸エダラボンの臨床効果に関する検証2023
- Author(s)
  湯淺知子，川頭祐一，丹羽淳一，道勇学
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Exploration of pathogenic molecules in motor neuron disease using the human ipsc-derived neuromuscular model2023
- Author(s)
  Ito T, Rashid MI, Onodera K, Okada R, Shimojo D, Tanaka S, Katsuno M, Sobue G, Doyu M, Okano H, Okada Y
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K06975
[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2023
- Author(s)
  Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K06975
[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022
- Author(s)
  Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
- Organizer
  第33回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] SOD1-G93S変異陽性筋萎縮性側索硬化症患者の臨床遺伝学的特徴2022
- Author(s)
  中村亮一, 中杤昌弘, 熱田直樹, 藤内玄規, 伊藤大輔, 和泉唯信, 橋本里奈, 饗場郁子, 溝口功一, 金井数明, 青木正志, 柴田俊, 伊藤千弘, 湯淺知子, 徳井啓介, 川頭祐一, 丹羽淳一, 道勇学, 勝野雅央, 祖父江元
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07509
[Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022
- Author(s)
  伊藤卓治、ラシッド　ムハンマド　イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Bulk differentiation of iPSCs into contractible muscles for muscular disease modeling2022
- Author(s)
  Rashid MI, Ito T, Miya F, Shimojo D, Arimoto K, Onodera K, Okada R, Nagashima T, Yamamoto K, Khatun Z, Okano H, Sakurai H, Shimizu K, Doyu M, Okada Y
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2022
- Author(s)
  小野寺一成, 下門大祐, Bruno De Araujo Herculano1, 石原康晴, 依田真由子, 太田明伸, 矢野真人, 宮冬樹, Rashid Muhammad Irfanur, 伊藤卓治, 岡田梨奈, 角田達彦, 細川好孝, 道勇学, 祖父江元, 勝野雅央,岡野栄之,岡田洋平
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022
- Author(s)
  伊藤卓治、ラシッド　ムハンマド　イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
- Organizer
  第33回日本末梢神経学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] SOD1-G93S変異陽性筋萎縮性側索硬化症患者の臨床遺伝学的及び病理学的特徴2022
- Author(s)
  中村亮一、中杤昌弘、陸雄一、熱田直樹、藤内玄規、伊藤大輔、和泉　唯信、橋本里奈、饗場郁子、溝口功一、金井数明、青木正志、徳井啓介、川頭祐一、丹羽淳一、道勇学、岩崎靖、吉田眞理、勝野雅央、祖父江元
- Organizer
  日本人類遺伝学会第67回大会
- Data Source
  KAKENHI-PROJECT-22K07509
[Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022
- Author(s)
  伊藤卓治、ラシッド　ムハンマド　イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022
- Author(s)
  Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症（SBMA）の早期病態解明と治療開発2022
- Author(s)
  小野寺一成、下門大祐、石原康晴、太田明伸、Muhammad Irfanur Rashid、伊藤卓治、岡田梨奈、細川好孝、道勇学、祖父江元、勝野雅央、岡野栄之、岡田洋平
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022
- Author(s)
  Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2021
- Author(s)
  小野寺一成, 下門大祐, de Ara?jo Herculano B,石原康晴, 依田真由子, 太田明伸, 矢野真人, 宮冬樹, Rashid MI, 伊藤卓治, 岡田梨奈, 角田達彦, 細川好孝, 道勇学, 祖父江元, 勝野雅央, 岡野栄之, 岡田洋平
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Establishment of hiPSC-derived functional neuromuscular models for the analysis of neuromuscular diseases2021
- Author(s)
  伊藤卓治、ラシッドムハンマドイルファヌール、田中智史、下門大祐、岡野栄之、道勇学、岡田洋平
- Organizer
  ヒトiPS細胞由来運動ニューロンと骨格筋を用いた機能的神経筋共培養モデルの構築、第44回日本神経科学大会 CJK第1回国際会議
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Efficient, reproducible and functional differentiation of human iPSCs into skeletal muscles for muscular disease modeling.2021
- Author(s)
  Rashid MI, Ito T, Shimojo D, Khatun Z, Sakurai H, Shimizu K, Doyu M, Okada Y.
- Organizer
  ISSCR/JSRM 2021 Tokyo International Symposium, Tokyo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] The effects of g-secretase inhibitor on differentiation of iPSC-derived neurons2021
- Author(s)
  福井ナナミ、伊藤卓治、杉山香織、岡田梨奈、小野寺一成、Zohora Khatun、道勇学、岡田洋平
- Organizer
  第44回日本神経科学大会 CJK第1回国際会議
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Efficient, reproducible, and functional differentiation of human induced pluripotent stem cells (iPSCs) into skeletal muscles for muscular disease modeling.2021
- Author(s)
  Rashid MI, Ito T, Shimojo D, Khatun Z, Sakurai H, Shimizu K, Doyu M, Okada Y.
- Organizer
  PACTALS 2021 NAGOYA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] 脳卒中患者における自律神経機能と病状との関連2021
- Author(s)
  中島康自, 小出弘文, 林未久, 伊藤千弘, 湯淺知子, 安本明弘, 安藤宏明, 田口宗太郎, 藤掛彰史, 福岡敬晃, 徳井啓介, 川頭祐一, 岡田洋平, 丹羽淳一, 道勇学
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Elucidating early pathophysiology of Spinal-bulbar muscular atrophy using diseasespecific iPSCs.2021
- Author(s)
  Onodera K, Shimojo D, de Ara?jo Herculano B, Ishihara Y, Yoda M, Ota A, Rashid MI, Ito T, Okada R, Hosokawa Y, Doyu M, Sobue G, Katsuno M, Okano H, Okada Y
- Organizer
  ISSCR/JSRM 2021 Tokyo International Symposium, Tokyo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Establishment of iPSC-derived neuromuscular co-culture model for the analysis of non-cell autonomous neurodegeneration in motor neuron diseases2021
- Author(s)
  Ito T, Rashid MI, Tanaka S, Shimojo D, Okano H, Doyu M, Okada Y.
- Organizer
  ISSCR/JSRM 2021 Tokyo International Symposium, Tokyo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] 疾患iPS細胞による神経・筋共培養を活用した神経変性疾患の病態解析2020
- Author(s)
  伊藤卓治, 小野寺一成, 小野寺一成, 下門大祐, 下門大祐, 田中智史, 田中智史, 岡田梨奈, RASHID Muhammad Irfanur, 道勇学, 岡野栄之, 岡田洋平
- Organizer
  日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Reconstruction of motor function in peripheral nerves by transplanatation of human iPSC-derived motor neuron progenitors.2019
- Author(s)
  Niwa S, Saeki M, Shinkai H, Kurimoto S, Hirata H, Doyu M, Okada Y
- Organizer
  ISSCR 2019 Annual Meeting, LosAngeles
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Pathophysiological analysis of spinal and bulbar muscular atrophy using disease-specific iPSCs.2019
- Author(s)
  Onodera K， Shimojo D， Yoda M, Ishihara Y， Ito T, Okada R, Doyu M， Katsuno M， Okano H， Sobue G， Okada Y
- Organizer
  第60回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Elucidation of non-cell autonomous neurodegeneration in spinal and bulbar muscular atrophy using iPSC-derived neuromuscular models.2019
- Author(s)
  Ito T, Tanaka S, Shimojo D, Doyu M, Okano H, Okada Y
- Organizer
  ISSCR 2019 Annual Meeting, LosAngeles
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] The effects of hypoxia on differentiation and maturation of human induced pluripotent stem cell-derived neural progenitors.2019
- Author(s)
  Okada Y, Okada R, Li J, Onodera K, Ito T, Okano HJ, Doyu M
- Organizer
  ISSCR 2019 Annual Meeting, LosAngeles
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07969
[Presentation] Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy2009
- Author(s)
  Banno, H., Katsuno, M., Suzuki, K., Takeuchi, Y., Kawashima, M., Suga, N., Takamori, M., Ito, M., Nakamura, T., Matsuo, K., Yamada, S., Oki, Y., Adachi, H., Minamiyama, M., Waza, M., Atsuta, N., Watanabe, H., Fujimoto, Y., Nakashima, T., Tanaka, F., Doyu, M., Sobue, G.
- Organizer
  61th American Academy of Neurology Annual Meeting
- Place of Presentation
  Seattle, USA
- Data Source
  KAKENHI-PROJECT-17025020
[Presentation] Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy.2009
- Author(s)
  Banno H, Katsuno M, Suzuki K, Takeuchi Y, Kawashima M, Suga N, Takamori M, Ito M, Nakamura T, Matsuo K, Yamada S, Oki Y, Adachi H, Minamiyama M, Waza M, Atsuta N, Watanabe H, Fujimoto Y, Nakashima T, Tanaka F, Doyu M, Sobue G.
- Organizer
  61th American Academy of Neurology Annual Meeting
- Place of Presentation
  Seattle, USA
- Year and Date
  2009-04-26
- Data Source
  KAKENHI-PROJECT-17025020
[Presentation] 孤発性ALS疾患モデルの開発 : dynactin1ノックダウン細胞の解析2007
- Author(s)
  田中章景、黄哲、蒋月梅、松尾幸治、和座雅浩、山本正彦、道勇学、祖父江元
- Organizer
  第48回日本神経学会総会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-16
- Data Source
  KAKENHI-PROJECT-19390238
[Presentation] Gen expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis2006
- Author(s)
  Tanaka, F., Jiang, Y.M., Yamamoto, M., Huang, Z., Katsuno, M., Adachi, H., Niwa, J.I., Doyu, M., Sobue, G.
- Organizer
  17th International Symposium on ALS/MND
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-17025020

1. SOBUE Gen (20148315)

# of Collaborated Projects: 16 results

# of Collaborated Products: 90 results
2. TANAKA Fumiaki (30378012)

# of Collaborated Projects: 8 results

# of Collaborated Products: 66 results
3. INUKAI Akira (30314016)

# of Collaborated Projects: 6 results

# of Collaborated Products: 3 results
4. KATSUNO Masahisa (50402566)

# of Collaborated Projects: 3 results

# of Collaborated Products: 38 results
5. ADACHI Hiroaki (40432257)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
6. 岡田洋平 (30383714)

# of Collaborated Projects: 2 results

# of Collaborated Products: 33 results
7. 伊藤卓治 (30794151)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
8. 熱田直樹 (90547457)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
9. 中村亮一 (80723030)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
10. 藤内玄規 (00748353)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
11. IIJIMA Masahiro (40437041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YAMAMOTO Masahiko (40378039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 服部直樹 (10402570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 柿崎裕彦 (20329783)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 中野隆 (30148332)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 高橋靖弘 (70557206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 陸雄一 (50748382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 小野寺一成 (80895772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
19. 若井正一

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 丹羽淳一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Doyu Manabu 道勇 学

道勇 学 ドウユウ マナブ

DOYU Manabu 道勇 学

Research Projects

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Co-Researchers

Establishment of efficient pathological analysis and drug discovery platform for amyotrophic lateral sclerosis using disease specific iPSCsPrincipal Investigator

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Elucidaion of muscular pathology of SBMA using disease specific iPSCsPrincipal Investigator

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分子シャペロンによる運動ニューロン疾患治療法の開発-SBMA・ALSを中心に-Principal Investigator

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ユビキチンリガーゼDorfinの基質タンパク質の探索-神経変性との関連Principal Investigator

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Development of low-molecular-weight compound therapy for polyglutamine diseasesPrincipal Investigator

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孤発性ALSにおけるユビキチンリガーゼDorfinの基質タンパク質の探索Principal Investigator

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Doyu Manabu 道勇学

道勇学ドウユウマナブ

DOYU Manabu 道勇学