Shimizu Makiko 清水万紀子

… Alternative Names

SHIMIZU Makiko 清水万紀子

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Researcher Number	90307075
Other IDs
Affiliation (Current)	2025: 昭和薬科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 昭和薬科大学, 薬学部, 准教授 2012 – 2017: 昭和薬科大学, 薬学部, 講師 2007 – 2011: Showa Pharmaceutical University, Depf. Of Pharmacy, Assistant Professor 2008: 昭和薬科大, 薬学部, 助教 2005 – 2007: 昭和薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Medical pharmacy / Basic Section 47060:Clinical pharmacy-related / Environmental pharmacy / Anesthesiology/Resuscitation studies
Keywords	Principal Investigator フラビン含有酸素添加酵素 / FMO3 / FMO / トリメチルアミン / Japanese / genetic polymorphism / trimethylaminuria / 薬物代謝 / サル / 薬物相互作用 … More / フラビン含有酸素添酵素 / 相互作用 / 薬物代謝酵素 / フラビン含有酸素添加酵素3 / フラビン含有モノオキシゲナーゼ3 / 小児 / フラビン含有モノオキシゲナーゼ / トリメチルアミン尿症 / 転写調節 / FM03 / ハプロタイプ / 遺伝子多型 / 転写因子 / 5'-上流領域 / 個人差 / menstruation … More Except Principal Investigator P450 / サリドマイド / 酵素誘導 / 遺伝子多型 / 胎盤 / 代謝的活性化 / チトクロムP450 / 不活性化 / BeWo細胞 / 肝細胞 / レナリドマイド / 薬物代謝酵素 / CYP3A5 / CYP3A / CYP3A4 / HepaRG / CYP2B6 / 薬物相互作用 / パロキセチン / アトモキセチン / P450 2D6 / 相互作用予測 / S-ワルファリン / クマリン / アザムリン / チエニリン酸 / フラフィリン / ヒト肝細胞移植マウス / 毒性評価 / 連結型培養手法 / 共存培養 / 胎盤細胞 / 膜透過 / 胎盤透過性 / ヒト幹細胞 / 薬学 / 培地組成 / 培養時間 / iPS / 薬物透過性 / ips細胞 / ヒト肝由来HepaＲG cells / 初代培養肝細胞 / 3次元培養法 / iPS細胞 / 培養肝細胞 / 長期間維持培地 / サイトカイン / ポマリドミド / レナリドミド / 肝 / 生理学的薬物動態 / フタル酸エステル / ポマリドマイド / Pronofol / Voriconazole / Thalidomide / Metabolic activation / Toxicity / 奇形 / 胎仔全培養 / ヒト型モデル動物 / CYP3A7 / ヒト型モデル / Tgマウス / 胎児毒性 / ヒト肝移植マウス / P450 3A / P4502D6 / HPLC / アルツハイマー治療薬 / 抗うつ薬 / アレル頻度 / P4503A422 / 抗精神薬 / CYP2D6 / 相互作用 / 向精神薬 / グルタチオン付加体 / 反応性代謝物 / ヒト肝移植キメラマウス / ヒト型薬物代謝 / P450 3A4 / 薬物代謝 / ミダゾラム水酸化活性 / 促進定数 / GSH / ヒト型モデルマウス / 協同性 / CYP2B66 / 覚醒遅延 / プロポフォール / 麻酔学 / 体臭 / トリメチルアミン / 個人差 / FMO3 Less

Functional analysis of flavin-containing monooxygenases using species differences and human polymorphisms in primary structuresPrincipal Investigator
- Principal Investigator
  
  清水万紀子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
遺伝的多型の定量的予測のための酵素不活化ヒト肝細胞移植マウスと動態モデリング開発
- Principal Investigator
  
  山崎浩史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
Prediction system of risk assessments by change the drug metabolism activity in placenta for pregnancy
- Principal Investigator
  
  Murayama Norie
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
Roles of human cytochrome P450 1A2, 2C9, and 3A4/5 enzymes in drug oxidations mediated by metabolically inactivated human hepatocytes in previously transplanted chimeric mice
- Principal Investigator
  
  Yamazaki Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
Evaluation for pharmacokinetics of chemicals mediated by flavin-containing monooxygenases using humanized animal modelsPrincipal Investigator
- Principal Investigator
  
  Shimizu Makiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Showa Pharmaceutical University
Relevance to bioactivation and toxicity of thalidomide, pomalidomide, and lenalidomide by human cytochrome P450 3A enzymes in cultured placental cells and humanized-liver mice
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Prediction system of risk assessments by change the drug metabolism activity in placenta for pregnancy
- Principal Investigator
  
  MURAYAMA Norie
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Pharmacokinetics prediction of drugs in humans associated with flavin-containing monooxygenase dependent-oxygenations in livers and kidneys of animal modelsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Makiko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Evaluaion of Human Cytochrome P450 3A Enzymes in Hepatic and Placental Cells by Thalidomide and Relevance to Bioactivation
- Principal Investigator
  
  Yamazaki Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Drug oxygenations and interactions mediated by polymorphic flavin-containing monooxygenasesPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Makiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
The most suitable administration of antidepressive drug to avoid risk of side effects in patient
- Principal Investigator
  
  MURAYAMA Norie
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Thalidomide increases cytochrome P450 activity and drug metabolism in liver through direct activation of nuclear receptor CAR and PXR
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Developmental variations in metabolic capacity of flavin-containing monooxygenase 3 in childhoodPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Makiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Drug interaction of thalidomide with midazolam and other compounds : heterotropic cooperativiy of human cyochrome P450
- Principal Investigator
  
  MURAYAMA Norie
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Inter-individual variations of flavin-containing monooxygenase 3 levels associated with multiple regulation factorsPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Makiko
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Polymorphic drug-metabolizing enzymes of anesthetics agent propofol rekated to its infusion syndrome.
- Principal Investigator
  
  MURAYAMA Norie
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Showa Pharmaceutical University
Interindividual variations of flavin-containing monooxygenase 3 (FMO3) related to menstruationPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Makiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらす薬物相互作用と疾病の個人差
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Molecular mechanism of chemical-induced toxicity in fetal livers
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa Pharmaceutical University

[Book] OECD Environment, Health and Safety Publications Series on Testing and Assessment no. 3312021
- Author(s)
  Tomonori Miura, Hiroshi Suemizu, Masatomo Goto, Norifumi Sakai, Hiroshi Iwata, Makiko Shimizu, Hiroshi Yamazaki
- Total Pages
  101
- Publisher
  OECD
- Data Source
  KAKENHI-PROJECT-20K07164
[Book] 先天代謝異常ハンドブック (トリメチルアミン尿症（魚臭症候群）)2013
- Author(s)
  山崎浩史、清水万紀子
- Total Pages
  456
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-25460198
[Book] 先天代謝異常ハンドブック (第2 章トリメチルアミン尿症(魚臭症候群))2012
- Author(s)
  山崎浩史、清水万紀子
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23790200
[Book] 先天代謝異常ハンドブック (第2章　トリメチルアミン尿症（魚臭症候群）)2012
- Author(s)
  山崎浩史、清水万紀子
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23790200
[Book] 臨床薬理の進歩2008
- Author(s)
  山崎浩史、清水万紀子、永島里美、村山典恵
- Total Pages
  6
- Publisher
  薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらすアミン化合物酸化的代謝の個人差に関する研究
- Data Source
  KAKENHI-PROJECT-19790134
[Book] 臨床薬理の進歩No.292008
- Author(s)
  山崎浩史、清水万紀子、永島里美、村山典恵
- Publisher
  臨床薬理研究振興財団
- Data Source
  KAKENHI-PROJECT-19790134
[Book] 臨床薬理研究進行財団2007
- Author(s)
  山崎浩史, 清水万紀子, 永島里美, 村山典恵
- Publisher
  薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらすアミン化合物酸化的代謝の個人差に関する臨床薬理学研究「臨床薬理の進歩No.29」
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Book] 臨床薬理研究進行財団(印刷中)2007
- Author(s)
  山崎浩史, 清水万紀子, 永島里美, 村山典恵
- Publisher
  薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらすアミン化合物酸化的代謝の個人差に関する臨床薬理学研究「臨床薬理の進歩No.29」
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] High hepatic and plasma exposures of atorvastatin in subjects harboring impaired cytochrome P450 3A4?16 modeled after virtual administrations and possibly associated with statin intolerance found in the Japanese adverse drug event report database2023
- Author(s)
  Adachi Koichiro、Ohyama Katsuhiro、Tanaka Yoichi、Sato Tasuku、Murayama Norie、Shimizu Makiko、Saito Yoshiro、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 49 Pages: 100486-100486
- DOI
  10.1016/j.dmpk.2022.100486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07164
[Journal Article] Roles of human cytochrome P450 3A4/5 in dexamethasone 6β-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin.2023
- Author(s)
  Uehara S, Shimizu M, Suemizu H, Yamazaki H.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 50 Pages: 100504-100504
- DOI
  10.1016/j.dmpk.2023.100504
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06463, KAKENHI-PROJECT-20K07164, KAKENHI-PROJECT-23K06217
[Journal Article] Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css-MRTpo method and chimeric mice with humanised livers.2023
- Author(s)
  Kamimura H, Uehara S, Yoneda N, Suemizu H.
- Journal Title
  
  Xenobiotica
  
  Volume: 53 Issue: 1 Pages: 523-535
- DOI
  10.1124/dmd.123.001481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05621, KAKENHI-PROJECT-23K06217
[Journal Article] Plasma concentration profiles for hepatotoxic pyrrolizidine alkaloid senkirkine in humans extrapolated from rat data sets using a simplified physiologically based pharmacokinetic model.2022
- Author(s)
  Kamiya, Y., Miura, T., Kato, A., Murayama, N., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Drug Metab Bioanal Lett
  
  Volume: 15 Issue: 1 Pages: 64-69
- DOI
  10.2174/1872312801666211220110055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07139
[Journal Article] Probe drug T-1032 N-oxygenation mediated by cytochrome P450 3A5 in human hepatocytes in vitro and in humanized-liver mice in vivo.2022
- Author(s)
  Uehara S, Shimizu M, Ple K, Routier S, Yoneda N, Higuchi Y, Suemizu H, Yamazaki H.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 44 Pages: 100453-100453
- DOI
  10.1016/j.dmpk.2022.100453
- NAID
  210000188903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06463, KAKENHI-PROJECT-20K07164
[Journal Article] Species Specificity and Selection of Models for Drug Oxidations Mediated by Polymorphic Human Enzymes2022
- Author(s)
  Yamazaki Hiroshi、Shimizu Makiko
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 51 Issue: 1 Pages: 123-129
- DOI
  10.1124/dmd.121.000742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07164, KAKENHI-PROJECT-23K06217
[Journal Article] Different substrate elimination rates of model drugs pH-dependently mediated by flavin-containing monooxygenases and cytochromes P450 in human liver microsomes2021
- Author(s)
  Taniguchi-Takizawa Tomomi、Kato Nozomu、Shimizu Makiko、Kume Toshiyuki、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 40 Pages: 100412-100412
- DOI
  10.1016/j.dmpk.2021.100412
- NAID
  210000159914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals2021
- Author(s)
  Kamiya Yusuke、Handa Kentaro、Miura Tomonori、Yanagi Mayu、Shigeta Kazuki、Hina Shiori、Shimizu Makiko、Kitajima Masato、Shono Fumiaki、Funatsu Kimito、Yamazaki Hiroshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 34 Issue: 2 Pages: 507-513
- DOI
  10.1021/acs.chemrestox.0c00336
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16422, KAKENHI-PROJECT-20K07164
[Journal Article] In vivo drug interactions of itopride and trimethylamine mediated by flavin-containing monooxygenase 3 in humanized-liver mice2021
- Author(s)
  Shimizu Makiko、Uehara Shotaro、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 37 Pages: 100369-100369
- DOI
  10.1016/j.dmpk.2020.11.004
- NAID
  210000164669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205, KAKENHI-PROJECT-20K06463
[Journal Article] Roles of human cytochrome P450 1A2 in coumarin 3,4-epoxidation mediated by untreated hepatocytes and by those metabolically inactivated with furafylline in previously transplanted chimeric mice2021
- Author(s)
  Miura Tomonori、Uehara Shotaro、Shimizu Makiko、Murayama Norie、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 11 Pages: 525-530
- DOI
  10.2131/jts.46.525
- NAID
  130008110376
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-20K06463, KAKENHI-PROJECT-20K07164
[Journal Article] Genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects identified by phenotyping for trimethylaminuria and found in a database of genome resources2021
- Author(s)
  Shimizu Makiko、Koibuchi Natsumi、Mizugaki Ami、Hishinuma Eiji、Saito Sakae、Hiratsuka Masahiro、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 38 Pages: 100387-100387
- DOI
  10.1016/j.dmpk.2021.100387
- NAID
  210000160257
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] Predicted Contributions of Flavin-containing Monooxygenases to the N-oxygenation of Drug Candidates Based on their Estimated Base Dissociation Constants2021
- Author(s)
  Taniguchi-Takizawa Tomomi、Kato Harutoshi、Shimizu Makiko、Yamazaki Hiroshi
- Journal Title
  
  Current Drug Metabolism
  
  Volume: 22 Issue: 3 Pages: 208-214
- DOI
  10.2174/1389200221666201207195758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models2021
- Author(s)
  Miura Tomonori、Kamiya Yusuke、Uehara Shotaro、Murayama Norie、Shimizu Makiko、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Xenobiotica
  
  Volume: － Issue: 6 Pages: 1-7
- DOI
  10.1080/00498254.2021.1908643
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16422, KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-20K07139
[Journal Article] An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats2021
- Author(s)
  Kamiya, Y. Handa, K. Miura, T. Ohori, J. Shimizu, M. Kitajima, M. Shono, F. Funatsu, K. Yamazaki, H.
- Journal Title
  
  Chem Res Toxicol
  
  Volume: 34 Issue: 10 Pages: 2180-2183
- DOI
  10.1021/acs.chemrestox.1c00249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07164
[Journal Article] A series of simple detection systems for genetic variants of flavin-containing monooxygenase 3 (FMO3) with impaired function in Japanese subjects2021
- Author(s)
  Shimizu Makiko、Mizugaki Ami、Koibuchi Natsumi、Sango Haruna、Uenuma Yumi、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 41 Pages: 100420-100420
- DOI
  10.1016/j.dmpk.2021.100420
- NAID
  210000186929
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] Different roles of human cytochrome P450 2C9 and 3A enzymes in diclofenac 4'- and 5-hydroxylations mediated by metabolically inactivated human hepatocytes in previously transplanted chimeric mice.2020
- Author(s)
  .Miura, T., Uehara, S., Shimizu, M., Murayama, N., Utoh, M., Suemizu, H., and Yamazaki, H.
- Journal Title
  
  Chem. Res. Toxicol.
  
  Volume: 33 Issue: 2 Pages: 634-639
- DOI
  10.1021/acs.chemrestox.9b00446
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07139, KAKENHI-PROJECT-20K07164
[Journal Article] Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential2020
- Author(s)
  Miura Tomonori、Shimizu Makiko、Uehara Shotaro、Yoshizawa Manae、Nakano Ayane、Yanagi Mayu、Kamiya Yusuke、Murayama Norie、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 33 Issue: 12 Pages: 3048-3053
- DOI
  10.1021/acs.chemrestox.0c00387
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07164, KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-19K16422
[Journal Article] Metabolic profiles of coumarin in human plasma extrapolated from a rat data set with a simplified physiologically based pharmacokinetic model2020
- Author(s)
  47.Miura T, Kamiya Y, Hina S, Kobayashi Y, Murayama N, Shimizu M, Yamazaki H.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 11 Pages: 695-700
- DOI
  10.2131/jts.45.695
- NAID
  130007935150
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07139, KAKENHI-PROJECT-20J21210, KAKENHI-PROJECT-19K16422
[Journal Article] Determination and prediction of permeability across intestinal epithelial cell monolayer of a diverse range of industrial chemicals/drugs for estimation of oral absorption as a putative marker of hepatotoxicity.2020
- Author(s)
  .Kamiya, Y., Takaku, H., Yamada, R., Akase, C., Abe, Y., Sekiguchi, Y., Murayama, N., Shimizu, M., Kitajima, M., Shono, F., Funatsu, K., and Yamazaki, H.
- Journal Title
  
  Toxicol. Rep.
  
  Volume: 149 Pages: 149-154
- DOI
  10.1016/j.toxrep.2020.01.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07139, KAKENHI-PROJECT-19K16422
[Journal Article] Novel variants in outer protein surface of flavin-containing monooxygenase 3 found in an Argentinian case with impaired capacity for trimethylamine N-oxygenation2020
- Author(s)
  Dionisio Leonardo、Shimizu Makiko、Stupniki Sofia、Oyama Saki、Aztiria Eugenio、Alda Maximiliano、Yamazaki Hiroshi、Spitzmaul Guillermo
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 35 Issue: 4 Pages: 383-388
- DOI
  10.1016/j.dmpk.2020.05.003
- NAID
  50014558612
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] Different Effects of Polymorphic Flavin-Containing Monooxygenase 3 and Cytochrome P450 2A6 Activities on an Index of Arteriosclerosis as a Lifestyle-Related Disease in a General Population in Japan2020
- Author(s)
  Uraoka Mirai、Shimizu Makiko、Kuwajima Yoshiki、Mizugaki Ami、Yokoyama Haruka、Mure Kanae、Yamazaki Hiroshi
- Journal Title
  
  Current Drug Metabolism
  
  Volume: 21 Issue: 14 Pages: 1161-1164
- DOI
  10.2174/1389200221666201009140802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205, KAKENHI-PROJECT-18H03054
[Journal Article] Trimethylamine N-oxygenation in cynomolgus macaques genotyped for flavin-containing monooxygenase 3 (FMO3)2020
- Author(s)
  Shimizu Makiko、Uno Yasuhiro、Utoh Masahiro、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 35 Issue: 6 Pages: 571-573
- DOI
  10.1016/j.dmpk.2020.07.001
- NAID
  50014656618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model2020
- Author(s)
  Miura Tomonori、Uehara Shotaro、Shigeta Kazuki、Yoshizawa Manae、Kamiya Yusuke、Murayama Norie、Shimizu Makiko、Suemizu Hiroshi、Yamazaki Hiroshi
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 34 Issue: 2 Pages: 522-528
- DOI
  10.1021/acs.chemrestox.0c00358
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16422, KAKENHI-PROJECT-20K06463, KAKENHI-PROJECT-20K07164
[Journal Article] Non-synonymous genetic variants of flavin-containing monooxygenase 3 (FMO3) in cynomolgus macaques.2019
- Author(s)
  Uno, Y., Shimizu, M., Yoda, H., Origuchi, Y., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Pharmacokinet.,
  
  Volume: 34 Issue: 1 Pages: 104-109
- DOI
  10.1016/j.dmpk.2018.09.001
- NAID
  50014558505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08380
[Journal Article] Novel variants and haplotypes of human flavin-containing monooxygenase 3 (FMO3) gene associated with Japanese subjects suffering from trimethylaminuria.2019
- Author(s)
  Shimizu, M., Yoda, H., Igarashi, N., Makino, M., Tokuyama, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: - Issue: 10 Pages: 1244-1250
- DOI
  10.1080/00498254.2018.1539279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08380
[Journal Article] Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate2019
- Author(s)
  Miura, T. Suemizu, H. Goto, M. Sakai, N. Iwata, H. Shimizu, M. Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 49 Issue: 5 Pages: 513-520
- DOI
  10.1080/00498254.2018.1471753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08425
[Journal Article] Expression and metabolic activity of flavin-containing monooxygenase 1 (FMO1) in cynomolgus macaque kidney.2019
- Author(s)
  Uno Y, Shimizu M, Yoda H, Yamazaki H.
- Journal Title
  
  J.Med.Primatol.
  
  Volume: 48 Issue: 1 Pages: 51-53
- DOI
  10.1111/jmp.12385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08380
[Journal Article] Steady-state human pharmacokinetics of monobutyl phthalate predicted by physiologically based pharmacokinetic modeling using single-dose data from humanized-liver mice orally administered with dibutyl phthalate2019
- Author(s)
  Miura, T. Uehara, S. Mizuno, S. Yoshizawa, M. Murayama, N. Kamiya, Y. Shimizu, M. Suemizu, H. Yamazaki, H.
- Journal Title
  
  Chemical Research in Toxicology
  
  Volume: 32 Issue: 2 Pages: 333-340
- DOI
  10.1021/acs.chemrestox.8b00361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08425
[Journal Article] Genetic variants of flavin-containing monooxygenase 3 (FMO3) derived from Japanese subjects with the trimethylaminuria phenotype and whole-genome sequence data from a large Japanese database.2019
- Author(s)
  Shimizu, M., Yoda, H., Nakakuki, K., Saso, A., Saito, I., Hishinuma, E., Saito, S., Hiratsuka, M., Yamazaki, H.
- Journal Title
  
  Drug Metab. Pharmacokinet.
  
  Volume: 34 Issue: 5 Pages: 334-339
- DOI
  10.1016/j.dmpk.2019.06.001
- NAID
  50014558523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07205
[Journal Article] Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice2018
- Author(s)
 Shimizu, M., Suemizu, H., Mizuno, S., Kusama, T., Miura, T., Uehara, S., and Yamazaki, H.
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 43 Issue: 6 Pages: 387-393
- DOI
 10.2131/jts.43.387
- NAID
 130007384444
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-16K08380
[Journal Article] Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA2018
- Author(s)
  Murayama Norie、Suemizu Hiroshi、Uehara Shotaro、Kusama Takashi、Mitsui Marina、Kamiya Yusuke、Shimizu Makiko、Guengerich F. Peter、Yamazaki Hiroshi
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 43 Issue: 6 Pages: 369-375
- DOI
  10.2131/jts.43.369
- NAID
  130007384441
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425, KAKENHI-PROJECT-17K08426
[Journal Article] Human plasma and urinary metabolic profiles of trimethylamine and trimethylamine N-oxide extrapolated using a simple physiologically based pharmacokinetic model2017
- Author(s)
 Shimizu M, Yamazaki H.
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 42 Issue: 4 Pages: 485-490
- DOI
 10.2131/jts.42.485
- NAID
 130005765918
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-16K08380
[Journal Article] Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice.2017
- Author(s)
  Shimizu M, Suemizu H, Mitsui M, Shibata N, Guengerich FP, Yamazaki H.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中 Issue: 10 Pages: 844-848
- DOI
  10.1080/00498254.2016.1247218
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08380, KAKENHI-PROJECT-17K08425
[Journal Article] Marmoset Flavin-Containing Monooxygenase 3 in the Liver Is a Major Benzydamine and Sulindac Sulfide Oxygenase.2017
- Author(s)
  Uehara, S., Shimizu, M., Uno, Y., Inoue, T., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 45 Issue: 5 Pages: 497-500
- DOI
  10.1124/dmd.117.075184
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18934, KAKENHI-PROJECT-16K08380
[Journal Article] Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice.2017
- Author(s)
  Yamazaki-Nishioka M, Shimizu M, Suemizu H, Nishiwaki M, Mitsui M, Yamazaki H.
- Journal Title
  
  Xenobiotica
  
  Volume: 印刷中 Issue: 2 Pages: 117-123
- DOI
  10.1080/00498254.2017.1288280
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08380
[Journal Article] Assessment of protein binding of 5-hydroxythalidomide bioactivated in humanized mice with human P450 3A-chromosome or hepatocytes by two-dimensional electrophoresis/accelerator mass spectrometry2016
- Author(s)
  Yamazaki, H., Suemizu, H., Kazuki, Y., Oofusa, K., Kuribayashi, S., Shimizu, M., Ninomiya, S., Horie, T., Shibata, N., and Guengerich, F. P.
- Journal Title
  
  Chem. Res. Toxicol.
  
  Volume: 29 Issue: 12 Pages: 1279-1281
- DOI
  10.1021/acs.chemrestox.6b00136
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460206
[Journal Article] Activation and deactivation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes and flavin-containing monooxygenases in common marmosets (Callithrix jacchus).2015
- Author(s)
  Uehara, S., Uno, Y., Inoue, T., Murayama, N., Shimizu, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos.
  
  Volume: 43 Issue: 5 Pages: 735-742
- DOI
  10.1124/dmd.115.063594
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18934, KAKENHI-PROJECT-25460198
[Journal Article] Oral L-carnitine supplementation increases trimethylamine-N-oxide, but reduces markers of vascular injury in hemodialysis patients.2015
- Author(s)
  Fukami K, Yamagishi S, Sakai K, Kaida Y, Yokoro M, Ueda S, Wada Y, Takeuchi M, Shimizu M, Yamazaki H, Okuda S.
- Journal Title
  
  J. Cardiovasc. Pharmacol.
  
  Volume: 65. Issue: 3 Pages: 289-295
- DOI
  10.1097/fjc.0000000000000197
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25282029, KAKENHI-PROJECT-26860487, KAKENHI-PROJECT-25460198
[Journal Article] Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers.2015
- Author(s)
  Shimizu M, Shiraishi A, Sato A, Nagashima S, Yamazaki H.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 30 Issue: 1 Pages: 70-74
- DOI
  10.1016/j.dmpk.2014.09.008
- NAID
  50014415982
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Benzydamine N-oxygenation as an index for flavin-containing monooxygenase activity and benzydamine N-demethylation by cytochrome P450 enzymes in liver microsomes from rats, dogs, monkeys, and humans.2015
- Author(s)
  Taniguchi-Takizawa T, Shimizu M, Kume T, Yamazaki H.
- Journal Title
  
  Drug Metab Pharmacokinet.
  
  Volume: 30 Issue: 1 Pages: 64-69
- DOI
  10.1016/j.dmpk.2014.09.006
- NAID
  50014415981
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Analysis of six novel flavin-containing monooxygenase 3 (FMO3) gene variants found in a Japanese population suffering from trimethylaminuria2015
- Author(s)
  Shimizu M, Origuchi Y, Ikuma M, Mitsuhashi N, Yamazaki H.
- Journal Title
  
  Molecular Genetics and Metabolism Reports
  
  Volume: 5 Pages: 89-93
- DOI
  10.1016/j.ymgmr.2015.10.013
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling2015
- Author(s)
  Utoh, M., Suemizu, H., Mitsui, M., Kawao, M., Toda, A., Uehara, S., Uno, Y., Shimizu, M., Sasaki, E., and Yamazaki, H.
- Journal Title
  
  Xenobiotica
  
  Volume: 46 Issue: 12 Pages: 1049-1055
- DOI
  10.3109/00498254.2016.1147102
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460206, KAKENHI-PROJECT-15K18934
[Journal Article] Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling2015
- Author(s)
  Miyaguchi,T.; Suemizu,H.; Shimizu,M.; Shida,S.; Nishiyama,S.; Takano,R.; Murayama,N.; Yamazaki,H.
- Journal Title
  
  Regul.Toxicol.Pharmacol.
  
  Volume: 72 Issue: 1 Pages: 71-76
- DOI
  10.1016/j.yrtph.2015.03.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460206
[Journal Article] Drug oxygenation activities mediated by liver microsomal flavin-containing monooxygenases 1 and 3 in humans, monkeys, rats, and minipigs.2014
- Author(s)
  Yamazaki M, Shimizu M, Uno Y, Yamazaki H.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 90 Issue: 2 Pages: 159-165
- DOI
  10.1016/j.bcp.2014.04.019
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Qualitative de novo analysis of full length cDNA and quantitative analysis of gene expression for common marmoset (Callithrix jacchus) transcriptomes using parallel long-read technology and short-read sequencing.2014
- Author(s)
  Shimizu M, Iwano S, Uno Y, Uehara S, Inoue T, Murayama N, Onodera J, Sasaki E, Yamazaki H.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 6 Pages: e100936-e100936
- DOI
  10.1371/journal.pone.0100936
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Trimethylamine generation in patients receiving hemodialysis treated with L-carnitine.2014
- Author(s)
  Ozasa, H., Shimizu, M., Koizumi, A., Wakabayashi, A., Yamazaki, H.
- Journal Title
  
  Clin.Kidney J.,
  
  Volume: 7 Issue: 3 Pages: 329-329
- DOI
  10.1093/ckj/sfu045
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Evaluation of 23 lots of commercially available cryopreserved hepatocytes for induction assays of human cytochromes p4502014
- Author(s)
  Yajima K, Uno Y, Murayama N, Uehara S, Shimizu M, Nakamura C, Iwasaki K, Utoh M, Yamazaki H
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 42 Issue: 5 Pages: 867-871
- DOI
  10.1124/dmd.113.056804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of pregnane X receptor2014
- Author(s)
  Murayama, N., van Beuningen, R., Suemizu, H., Guguen-Guillouzo, C., Shibata, N., Yajima, K., Utoh, M., Shimizu, M., Chesne, C., Nakamura, M., Guengerich, F. P., Houtman, R., and Yamazaki, H
- Journal Title
  
  Chem.Res.Toxicol
  
  Volume: 27 Issue: 2 Pages: 304-307
- DOI
  10.1021/tx4004374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-24590211, KAKENHI-PROJECT-26460206
[Journal Article] Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes2014
- Author(s)
  Suemizu,H.; Sota,S.; Kuronuma,M..; Shimizu,M.; Yamazaki,H.
- Journal Title
  
  Regul.Toxicol.Pharmacol.
  
  Volume: 70 Issue: 2 Pages: 468-473
- DOI
  10.1016/j.yrtph.2014.08.010
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460206
[Journal Article] Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population.2014
- Author(s)
  Shimizu M, Allerston CK, Shephard EA, Yamazaki H, Phillips IR.
- Journal Title
  
  Br J Clin Pharmacol.
  
  Volume: 77 Issue: 5 Pages: 839-851
- DOI
  10.1111/bcp.12240
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes2013
- Author(s)
  Okubo M, Murayama N, Shimizu M, Shimada T, Guengerich FP, Yamazaki H
- Journal Title
  
  J Toxicol Sci.
  
  Volume: 38 Pages: 349-354
- NAID
  10031158900
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Molecular and functional characterization of flavin-containing monooxygenases in cynomolgus macaque.2013
- Author(s)
  Uno, Y., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 85 Issue: 12 Pages: 1837-1847
- DOI
  10.1016/j.bcp.2013.04.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline2013
- Author(s)
  Utoh M, Murayama N, Uno Y, Onose Y, Hosaka S, Fujino H, Shimizu M, Iwasaki K, Yamazaki H
- Journal Title
  
  Xenobiotica
  
  Volume: 43 Issue: 12 Pages: 1037-1042
- DOI
  10.3109/00498254.2013.793874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling2013
- Author(s)
  Tsukada, A., Suemizu, H., Murayama, N., Takano, R., Shimizu, M., Nakamura, M., and Yamazaki, H
- Journal Title
  
  Regul.Toxicol.Pharmacol
  
  Volume: 65 Issue: 3 Pages: 316-324
- DOI
  10.1016/j.yrtph.2013.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200
[Journal Article] The CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes2013
- Author(s)
 Okubo, M., Murayama, N., Shimizu, M., Shimada, T., Guengerich, F. P., and Yamazaki, H.
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 38 Issue: 3 Pages: 349-354
- DOI
 10.2131/jts.38.349
- NAID
 10031158900
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-23590200
[Journal Article] Effects of ADH1C, ALDH2, and CYP2A6 polymorphisms on individual risk of tobacco-related lung cancer in male Japanese smokers.2013
- Author(s)
  Shimizu, M., Ishii, Y., Okubo, M., Kunitoh, H., Kamataki, T., and Yamazaki, H.
- Journal Title
  
  J.Cancer Ther
  
  Volume: 4 Issue: 08 Pages: 28-35
- DOI
  10.4236/jct.2013.48a005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities.2013
- Author(s)
  Yamazaki, H. and Shimizu, M.
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 85 Issue: 11 Pages: 1588-1593
- DOI
  10.1016/j.bcp.2013.03.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460198
[Journal Article] In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-hydroxythalidomide in humanized TK-NOG mice2012
- Author(s)
  Yamazaki, H., Suemizu, H., Shimizu, M., Igaya, S., Shibata, N., Nakamura, N., Chowdhury, G., and Guengerich, F.P
- Journal Title
  
  Chem Res Toxicol
  
  Volume: 25 Issue: 2 Pages: 274-276
- DOI
  10.1021/tx300009j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200
[Journal Article] Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs.2012
- Author(s)
  Mogi M, Toda A, Iwasaki K, Kusumoto S, Takehara H, Shimizu M, Murayama N, Izumi H, Utoh M, Yamazaki H.
- Journal Title
  
  J Toxicol Sci.
  
  Volume: 37 Pages: 1157-116
- NAID
  10031126020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590211
[Journal Article] A rapid multiplex PCR assay that can reliably discriminate the cytochrome P450 2D6 whole-gene deletion allele from 2D6*10 alleles.2012
- Author(s)
  Okubo, M., Murayama, N., Miura, J., Shimizu, M., and Yamazakik, H
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 413 Issue: 19-20 Pages: 1675-1677
- DOI
  10.1016/j.cca.2012.05.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-24590211
[Journal Article] Variants in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.2012
- Author(s)
  Shimizu, M., Kobayashi, Y., Hayashi, S., Aoki, Y., and Yamazaki, H.
- Journal Title
  
  Mol.Genet.Metab.
  
  Volume: 107 Issue: 3 Pages: 334-340
- DOI
  10.1016/j.ymgme.2012.06.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790200
[Journal Article] Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs2012
- Author(s)
  Mogi, M., Toda, A., Iwasaki, K., Kusumoto, S., Takahara, H., Shimizu, M., Murayama, N., Izumi, H., Utoh, M., and Yamazaki, H.
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 37 Issue: 6 Pages: 1157-1164
- DOI
  10.2131/jts.37.1157
- NAID
  130004447016
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200
[Journal Article] Note to readers. RE: "In vitro drug metabolism by C-terminally truncated human flavin-containing monooxygenase 3" by Catucci et al. (Biochemical Pharmacology, 83, 551-558, 2012).2012
- Author(s)
  Shimizu, M., Kobayashi, Y., and Yamazaki,H.
- Journal Title
  
  Biochem.Pharmacol.
  
  Volume: 84 Issue: 3 Pages: 411-411
- DOI
  10.1016/j.bcp.2012.05.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790200
[Journal Article] Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation2012
- Author(s)
  Hosoi, Y., Uno, Y., Murayama, N., Fujino, H., Shukuya, M., Iwasaki, K., Shimizu, M., Utoh, M., and Yamazaki, H.
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 84 Issue: 12 Pages: 1691-1695
- DOI
  10.1016/j.bcp.2012.09.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590200, KAKENHI-PROJECT-24590211
[Journal Article] Developmental variations in metabolic capacity of flavin-containing monooxygenase 3 in childhood2011
- Author(s)
  Shimizu, M., Denton, T., Kozono, M., Cashman, J. R., Leeder, J. S., and Yamazaki, H
- Journal Title
  
  Bri. J. Clin. Pharmacol
  
  Volume: 71 Issue: 4 Pages: 585-591
- DOI
  10.1111/j.1365-2125.2010.03876.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790200
[Journal Article] In Vivo Formation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG2011
- Author(s)
  Yamazaki, H., Suemizu, H.(8名・2番目)
- Journal Title
  
  Mice Chem Res Toxicol
  
  Volume: 24 Issue: 3 Pages: 287-289
- DOI
  10.1021/tx200005g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21240042, KAKENHI-PROJECT-21390030, KAKENHI-PROJECT-21590177, KAKENHI-PUBLICLY-22106515, KAKENHI-PROJECT-23590200
[Journal Article] Human liver enzymes responsible for metabolic elimination of tyramine, a vasopressor agent from daily food.2011
- Author(s)
  Niwa, T., Murayama, N., Umeyama, H., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Drug Metab.Lett.
  
  Volume: 5 Pages: 216-219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790200
[Journal Article] Human liver enzymes responsible for metabolic elimination of tyramine, a vasopressor agent from daily food2011
- Author(s)
  Niwa, T., Murayama, N., Umeyama, H., Shimizu, M., and Yamazaki, H
- Journal Title
  
  Drug Metab. Lett
  
  Volume: 5 Pages: 216-219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Different effects of TERT, TP63, and CYP2A6 polymorphism on individual risk of tobacco-related lung cancer in male Japanese smokers2011
- Author(s)
  Makiko Shimizu*, Kazuma Kiyotani*, Hideo Kunitoh, Tetsuya Kamataki, Hiroshi Yamazaki
- Journal Title
  
  J Cancer Ther
  
  Volume: 2 Issue: 05 Pages: 690-696
- DOI
  10.4236/jct.2011.25093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790179, KAKENHI-PROJECT-23790200
[Journal Article] Human liver enzymes responsible for metabolic elimination of tyramine, a vasopressor agent from daily food2011
- Author(s)
  Niwa, T., Murayama, N., Umeyama, H., Shimizu, M., Yamazaki, H.
- Journal Title
  
  Drug Metab.Lett
  
  Volume: 5 Pages: 216-219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Individual Differences in Pharmacokinetics and Pharmacodynamics of Anesthetic Agent Propofol with Regard to CYP2B6 and UGT1A9 Genotype and Patient Age2011
- Author(s)
  Kansaku, F, Kumai, T., Sasaki, K., Yukozuka, M., Shimizu, M., Tateda, T., Murayama, N., Kobayashi, S., Yamazaki, H.
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 26 Issue: 5 Pages: 532-537
- DOI
  10.2133/dmpk.DMPK-11-RG-039
- NAID
  130004463217
- ISSN
  1347-4367, 1880-0920
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177, KAKENHI-PROJECT-23790200
[Journal Article] Developmental variations in metabolic capacity of flavin-containing monooxygenase 3 in childhood.2011
- Author(s)
  Shimizu, M., Denton, T., Kozono, M., Cashman, J.R., Leeder, J.S., Yamazaki, H.
- Journal Title
  
  Bri.J.Clin.Pharmacol.
  
  Volume: 71 Pages: 585-591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790160
[Journal Article] Individual differences in pharmacokinetics and pharmacodynamics of anesthetic agent propofol with regard to CYP2B6 and UGT1A9 genotype and patient age2011
- Author(s)
  Kansaku F, Kumai T, Sasaki K, Yokozuka M, Shimizu M, Tateda T, Murayama N, Kobayashi S, Yamazaki H
- Journal Title
  
  Drug Metab Pharmacokinet
  
  Volume: 26 Pages: 532-7
- NAID
  130004463217
- URL
  http://dx.doi.org/10.2133/dmpk.DMPK-11-RG-039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Human liver enzymes responsible for metabolic elimination of tyramine, a vasopressor agent from daily food2011
- Author(s)
  Niwa, T., Murayama, N., Umeyama, H., Shimizu, M., and Yamazaki, H
- Journal Title
  
  Drug Metab.Lett
  
  Volume: 5 Pages: 216-219
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790200
[Journal Article] Direct genotyping of cytochrome P450 2A6 whole gene deletion from human blood samples by the SmartAmp method2011
- Author(s)
  Azuma, K., Lezhava, A., Shimizu, M., Kimura, Y., Ishizu, Y., Ishikawa, T., Kamataki,T. Hayashizaki, Y. and Yamazaki,H
- Journal Title
  
  Clin.Chim.Acta
  
  Volume: 412 Issue: 13-14 Pages: 1249-1251
- DOI
  10.1016/j.cca.2011.03.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790200
[Journal Article] Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate.2010
- Author(s)
  Chowdhury, G.., Murayama, N., Okada, Y., Uno, Y., Shimizu, M., Shibata, N., Guengerich, F.P., Yamazaki, H.
- Journal Title
  
  Chem.Res.Toxicol.
  
  Volume: 23 Pages: 1018-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population.2010
- Author(s)
  Nagano, T., Shimizu, M.Kiyotani, K., Kamataki, T., Takano, R., Murayama, N., Shono, F., H.Yamazaki.
- Journal Title
  
  Int.J.Environ.Res.Public Health
  
  Volume: 7 Pages: 2953-2964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790160
[Journal Article] 特異な体臭と代謝物分析:トリメチルアミン尿症を例として2010
- Author(s)
  山崎浩史、清水万紀子
- Journal Title
  
  ぶんせき
  
  Volume: 430 Pages: 510-512
- NAID
  10026787804
- Data Source
  KAKENHI-PROJECT-21790160
[Journal Article] In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice.2010
- Author(s)
  Yamazaki, H., Suemizu, H., Igaya, S., Shimizu, M., Shibata, N., Nakamura, M., Chowdhury, G., Guengerich, F.P.
- Journal Title
  
  Chem.Res.ToxicoL
  
  Volume: 24 Pages: 287-289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Human liver microsomal cytochrome P450 3A enzymes involved in thalidomide 5-hydroxylation and formation of a glutathione conjugate2010
- Author(s)
  Chowdhury, G., Murayama, N., Okada, Y., Uno, Y., Shimizu, M., Shibata, N., Guengerich, F. P., and Yamazaki, H
- Journal Title
  
  Chem. Res. Toxicol
  
  Volume: 23 Pages: 1018-1024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling.2010
- Author(s)
  Hiroshi Yamazaki, Kana Horiuchi, Ryohji Takano, Taku Nagano, Makiko Shimizu, Masato Kitajima, Norie Murayama, Fumiaki Shono
- Journal Title
  
  Int.J.Environ.Res.Public Health 7
  
  Pages: 3406-3421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790160
[Journal Article] Biomonitoring of urinary cotinine concentrations associated with plasma levels of nicotine metabolites after daily cigarette smoking in a male Japanese population.2010
- Author(s)
  Taku Nagano, Makiko Shimizu, Kazuma Kiyotani, Tetsuya Kamataki, Ryohji Takano, Norie Murayama, Fumiaki Shono, Hiroshi Yamazaki
- Journal Title
  
  Int.J.Environ.Res.Public Health 7
  
  Pages: 2953-2964
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790160
[Journal Article] 特異な体臭と代謝物分析:トリメチルアミン尿症を例として2010
- Author(s)
  山崎浩史、清水万紀子
- Journal Title
  
  ぶんせき 430
  
  Pages: 510-512
- NAID
  10026787804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790160
[Journal Article] Drug interactions of thalidomide with midazolam and cyclosporine A: heterotropic cooperativity of human cytochrome P450 3A52009
- Author(s)
  Okada, Y., Murayama, N., Yanagida, C., Shimizu, M., Guengerich, F.P., and Yamazaki, H
- Journal Title
  
  Drug Metab.Dispos 37
  
  Pages: 18-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Bonitos with low content of malodorous trimethylamine as palliative care for self-reoorted Jananese trimethvlaminuria subiects.2009
- Author(s)
  Shimizu M, Kozono M, Murayama N, Yamazaki H.
- Journal Title
  
  Drug Metab Pharmacokinet. 24(6)
  
  Pages: 549-552
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790160
[Journal Article] Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies2009
- Author(s)
  Murayama, N., Kaneko, N., Horiuchi, K., Ohyama, K., Shimizu, M., Ito, K., Yamazaki, H
- Journal Title
  
  Drug Metab.Pharmacokinet. 24
  
  Pages: 404-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity : A structure-function relationship study2009
- Author(s)
  Shimada, T., Tanaka, K.Takenaka, S.Foroozesh, M.K., Murayama, N., Yamazaki, H., Guengerich, F.P., Komori, M.Murayama, N., Kaneko, N., Horiuchi, K., Ohyama, K., Shimizu, M., Ito, K., Yamazaki, H
- Journal Title
  
  Chem.Res.Toxicol. 22
  
  Pages: 1325-1333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590177
[Journal Article] Individual Differences of Drug-metabolizing Enzymes as Determinants for the Metabolic Fate of Chemicals A Study of Trimethylamine and Flavin-containing Monooxygenase 3-2009
- Author(s)
  Shimizu M
- Journal Title
  
  Yakugaku Zasshi 129
  
  Pages: 1351-1356
- NAID
  130000136124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790160
[Journal Article] Inter-individual variations of flavin-containing monooxygenase 3 in livers from Japanese : correlation with hepatic transcription factors2009
- Author(s)
  Nagashima, S., Shimizu, M., Yano, H., Murayama, N., Kumai, T., Kobayashi, S., Guengerich, F.P., and Yamazaki, H.
- Journal Title
  
  Drug Metab. Pharmacokinet (In press)
- NAID
  10025723470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] トリメチルアミン尿症(魚臭症候群)に関わる薬物酸化酵素フラビン含有モノオキシゲナーゼ3のゲノム薬理学2009
- Author(s)
  山崎浩史,清水万紀子
- Journal Title
  
  臨床薬理 40
- NAID
  10026442304
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Individual Differences of Drug-metabolizing Enzymes as Determinants for the Metabolic Fate of Chemicals -A Study of Trimethylamine and Flavin-containing Monooxygenase 3-2009
- Author(s)
  Makiko Shimizu
- Journal Title
  
  Yakugaku Zasshi 129
  
  Pages: 1351-1356
- NAID
  130000136124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790160
[Journal Article] Inter-individual variations of flavin-containing monooxygenase 3 in livers from Japanese : correlation with hepatic transcription factors.2009
- Author(s)
  Satomi Nagashima, Makiko Shimizu, Hiroshi Yano, Norie Murayama, Toshio Kumai, Shinichi Kobayashi, Fred P. Guengerich, Hiroshi Yamazaki
- Journal Title
  
  Drug Metab. Pharmacokinet. 24
  
  Pages: 218-225
- NAID
  10025723470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790160
[Journal Article] Bonitos with low content of malodorous trimethylamine as palliative care for self-reported Japanese trimethylaminuria subjects.2009
- Author(s)
  Makiko Shimizu, Marie Kozono, Norie Murayama, Hiroshi Yamazaki
- Journal Title
  
  Drug Metab Pharmacokinet. 24
  
  Pages: 549-552
- NAID
  10027119731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790160
[Journal Article] Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies.2009
- Author(s)
  Murayama N, Kaneko N, Horiuchi K, Ohyama K, Shimizu M, Ito K, Yamazaki H.
- Journal Title
  
  Drug Metab Pharmacokinet. 24(4)
  
  Pages: 404-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790160
[Journal Article] Complex mechanism underlying transcriptional control of the haplotyped flavin-containing monooxygenase 3 (FMO3) gene in Japanese : Different regulation between mutations in 5'-upstream d istal region and common element in proximal region2008
- Author(s)
  Shimizu, M., Murayama, N., Nagashima, S., Fujieda, M. and Yamazaki, H
- Journal Title
  
  Drug Metab. Pharmacokinet 23
  
  Pages: 54-58
- NAID
  10024187751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Increased transendothelial permeability of anti-cancer agent carboplatin with the aid of hyperbaric oxygenation2008
- Author(s)
  Yamazaki, H., Shimizu, M., Murayama, N., Tanaka, K., Nion, S., and Cecchelli, R.
- Journal Title
  
  Xenobiotica 38
  
  Pages: 1298-1304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Molecular evolution and balancing selection in the flavin-containing monooxygenase3 gene(FMO3)2008
- Author(s)
  Allerston, C.K., Shimizu, M., Fujieda, M., Shephard, E.A., Yamazaki, H. and Phillips, I.R.
- Journal Title
  
  Pharmacogenet.Genomics 17
  
  Pages: 827-839
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene(FMO3)2008
- Author(s)
  Allerston, C.K., Shimizu, M., Fujieda, M.Shepherd, E.A.Yamazaki, H.and Phillips, I.R.
- Journal Title
  
  Pharmacogenet.Genomics 17
  
  Pages: 827-839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Increased transendothelial permeability of anti-cancer agent carboplatin with aid of hyperbaric oxygenation2008
- Author(s)
  Yamazaki, H., Shimizu, M., Murayama, N., Tanaka, K., Nion, S., a nd Cecchelli, R.
- Journal Title
  
  Xenobiotica 38
  
  Pages: 1298-1304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Increased distribution of carboplatin, an anti-cancer agent, to rat brains with aid of hyperbaric oxygenation2008
- Author(s)
  Suzuki, Y., Tanaka, K., Negishi, D., Shimizu, M., Murayama, N., Hashimoto, T. and Yamazaki, H
- Journal Title
  
  Xenobiotica 38
  
  Pages: 1471-1475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Complex mechanism underlying transcriptional control of the haplotyped flavin-containing monooxygenase 3 (FMO3) gene in Japanese : Different regulation between mutations in 5'-upstream distal region and common element in proximal region2008
- Author(s)
  Shimizu, M., Murayama, N., Nagashima, S., Fujieda, M. and Yamazaki, H.
- Journal Title
  
  Drug Metab.Pharmacokinet 23
  
  Pages: 54-58
- NAID
  10024187751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Involvement of human cytochrome P450 2B6 in the ω- and 4-hydroxylation of the anesthetic agent propofol2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M., Guengerich, F.P., and Yamazaki, H
- Journal Title
  
  Xenobiotica 37
  
  Pages: 717-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Roles of CYP3A4 and CYP2C19 in methylhydroxylated and N-oxidized metabolite for mation from voriconazole,a new anti-fungal agent,in human liver microsomes.2007
- Author(s)
  Murayama, N., Imai, N., Nakane, T., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Biochem.Pharmacol. 73
  
  Pages: 2020-2026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Genein a Japanese Cohort2007
- Author(s)
  Shimizu, M.Tomioka, S., Murayama, N.and Yamazaki, H.
- Journal Title
  
  Drug Metab.Pharmacokinet. 22
  
  Pages: 61-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3(FMO3)on N- and S-oxygenation activities2007
- Author(s)
  Shimizu, M., Yano, H., Nagashima, S., Murayama, N., Zhang, J., Cashman, J.R. and Yamazaki, H
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 328-330
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Involvement of human cytochrome P450 2B6 in the ω- and 4-hydroxylation of the anesthetic agent propofol2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M., Guengerich, F.P., and Yamazaki, H.
- Journal Title
  
  Current Drug Metabolism 37
  
  Pages: 717-724
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population2007
- Author(s)
  Yamazaki, H., Fujita, H., Gunji, T., Zhang, Z., Kamataki, T., Cashman, J.R., Shimizu, M
- Journal Title
  
  Mol. Genet. Metab 90
  
  Pages: 58-63
- NAID
  120000971644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Effects of propofol analogs on glucuronidation of propofol, an anesthetic drug, by human liver microsomes2007
- Author(s)
  Shimizu, M., Matsumoto, Y., Yamazaki, H
- Journal Title
  
  Drug Metab.Lett 1
  
  Pages: 77-79
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Involvement of human cytochrome P450 2B6 in the □-and 4-hydroxylation of the a nesthetic agent propofol.2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M., Guengerich, F.P., and Yamazaki, H.
- Journal Title
  
  Xenobiotica 37
  
  Pages: 717-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene (FMO3)2007
- Author(s)
  Allerston, C.K., Shimizu, M., Fujieda, M. Shephard, E.A. Yamazaki, H. and Phillips, I.R.
- Journal Title
  
  Pharmacogenet.Genomics 17
  
  Pages: 827-839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Transient trimethylaminuria related to menstruation2007
- Author(s)
  Shimizu, M., Cashman, J.R. and Yamazaki, H.
- Journal Title
  
  BMC.Med.Genet 8
  
  Pages: 2-2
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities.2007
- Author(s)
  Shimizu M. et al.
- Journal Title
  
  Drug Metab Dispos. 35(3)
  
  Pages: 328-330
- Data Source
  KAKENHI-PROJECT-17659038
[Journal Article] Involvement of human cytochrome P450 2B6 in the ω- and 4-hydroxylation of the anesthetic agent propofol2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M., Guengerich, F.P., Yamazaki, H
- Journal Title
  
  Xenobiotica 37
  
  Pages: 717-724
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effects of propofol analogs on glucuronidation of propofol,an anesthetic drug,by human liver microsomes2007
- Author(s)
  Shimizu, M., Matsumoto, Y., and Yamazaki, H.
- Journal Title
  
  Drug Metab.Lett 1
  
  Pages: 77-79
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3(FMO3) on N- and S-oxygenation activities2007
- Author(s)
  Shimizu, M., Yano, H., Nagashima, S., Murayama, N., Zhang, J., Cashman, J.R. Yamazaki, H
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 328-330
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Gene in a Japanese Cohort, Drug Metab2007
- Author(s)
  Shimizu, M., Tomioka, S., Murayama, N., and Yamazaki, H
- Journal Title
  
  Pharmacokinet 22
  
  Pages: 61-64
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.2007
- Author(s)
  Yamazaki H, Fujita H, Gunji T, Zhang Z, Kamataki T, Cashman JR, Shimizu, M
- Journal Title
  
  Mol.Genet.Metab. 90
  
  Pages: 58-63
- NAID
  120000971644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3(FMO3)on N-and S-oxygenation activities2007
- Author(s)
  Shimizu, M., Yano, H., Nagashima, S.Murayama, N., Zhang, J., Cashman, J.R.and Yamazaki, H
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 328-330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Transient trimethylaminuria related to menstruation.2007
- Author(s)
  Shimizu, M., Cashman, J.R., Yamazaki, H.
- Journal Title
  
  BMC Med Genet. 8
  
  Pages: 2-2
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Gene in a Japanese Cohort2007
- Author(s)
  Shimizu, M., Tomioka, S., Murayama, N. and Yamazaki, H.
- Journal Title
  
  Drug Metab.Pharmacokinet. 22
  
  Pages: 61-64
- NAID
  10018733032
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Roles of CYP3A4 and CYP2C19 in methylhydroxylated and N-oxidized metabolite formation from voriconazole,a new anti-fungal agent,in humanlive rmicrosomes.2007
- Author(s)
  Murayama, N., Imai, N., Nakane, T., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Biochem.Pharmacol 73
  
  Pages: 2020-2026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3 (FMO3) on N-and S-oxygenation activities2007
- Author(s)
  Shimizu, M., Yano, H., Nagashima, S.Murayama, N., Zhang, J., Cashman, J.R. and Yamazaki, H
- Journal Title
  
  Drug Metab.Dispos 35
  
  Pages: 328-330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Roles of CYP3A4 and CYP2C19 in methylhydroxylated and N-oxidized metabolite for mation from voriconazole,a new anti-fungal agent,in human liver microsomes2007
- Author(s)
  Murayama, N., Imai, N., Nakane, T., Shimizu, M., and Yamazaki, H.
- Journal Title
  
  Biochem.Pharmacol. 73
  
  Pages: 2020-2026
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Missense and nonsense mutations of the flavin-containing monooxygenase 3 gene in a Japanese cohort.2007
- Author(s)
  Shimizu, M. et al.
- Journal Title
  
  Drug Metab. Pharmacokinet. 22(1)
  
  Pages: 61-64
- NAID
  10018733032
- Data Source
  KAKENHI-PROJECT-17659038
[Journal Article] Transient trimethylaminuria related to menstruation.2007
- Author(s)
  Shimizu M. et al.
- Journal Title
  
  BMC Med Genet. 8
  
  Pages: 2-2
- Data Source
  KAKENHI-PROJECT-17659038
[Journal Article] Roles of CYP3A4 and CYP2C19 in methylhydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes2007
- Author(s)
  Murayama, N., Imai, N., Nakane, T., Shimizu, M., and Yamazaki, H
- Journal Title
  
  Biochem.Pharmacol 73
  
  Pages: 2020-2026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Transient trimethylaminuria related to menstruation2007
- Author(s)
  Shimizu, M., Cashman, J.R. and Yamazaki, H
- Journal Title
  
  BMC. Med. Genet 8
  
  Pages: 2-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Transient trimethylaminuria related to menstruation2007
- Author(s)
  Shimizu, M., Cashman, J.R. and Yamazaki, H.
- Journal Title
  
  BMC.Med.Genet. 8
  
  Pages: 2-2
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Missense and Nonsense Mutations of the Flavin-containing Monooxygenase 3 Gene in a Japanese Cohort2007
- Author(s)
  Shimizu, M.Tbmioka, S., Murayama, N. and Yamazaki, H.
- Journal Title
  
  Drug Metab.Pharmacokinet. 22
  
  Pages: 61-64
- NAID
  10018733032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] Molecular evolution and balancing selection in the flavin-containing monooxygenase 3 gene(FMO3)2007
- Author(s)
  Allerston, C.K., Shimizu, M., Fujieda, M., Shephard, E.A., Yamazaki, H., Phillips, I.R
- Journal Title
  
  Pharmacogenet.Genomics 17
  
  Pages: 827-839
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Roles of CYP3A4 and CYP2C19 in methylhydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes2007
- Author(s)
  Murayama, N., Imai, N., Nakane, T., Shimizu, M., Yamazaki, H
- Journal Title
  
  Biochem.Pharmacol 73
  
  Pages: 2020-2026
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population2007
- Author(s)
  Yamazaki H, Fujita H, Gunji T, Zhang Z, Kamataki T, Cashman JR, Shimizu, M
- Journal Title
  
  Mol.Genet.Metab. 90
  
  Pages: 58-63
- NAID
  120000971644
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Transient trimethylaminuria related to menstruation2007
- Author(s)
  Shimizu, M., Cashman, J.R., Yamazaki, H
- Journal Title
  
  BMC.Med.Genet
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Guengerich, F.P., and Yamazaki, H. Involvement of human cytochrome P450 2B6 in the omega- and 4-hydroxylation of the anesthetic agent propofol2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M
- Journal Title
  
  Xenobiotica 37
  
  Pages: 717-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591819
[Journal Article] lnvolvement of human cytochrome P450 2B6 in the ω-and 4-hydroxylation of the anesthetic agent propofol.2007
- Author(s)
  Murayama, N., Minoshima, M., Shimizu, M., Guengerich, F.P., and Yamazaki, H.
- Journal Title
  
  Current Drug Metabolism 37
  
  Pages: 717-724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Genetic polymorphism of the flavin-containing monooxygenase 3 (FMO3) associated with trimethylaminuria (fish odor syndrome): Observations from Japanese patients2007
- Author(s)
  Yamazaki H., and Shimizu, M
- Journal Title
  
  Current Drug Metabolism 8
  
  Pages: 487-491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Effects of propofol analogs on glucuronidation of propofol, an anesthetic drug, by human liver microsomes2007
- Author(s)
  Shimizu, M., Matsumoto, Y., and Yamazaki, H
- Journal Title
  
  Drug Metab.Lett 1
  
  Pages: 77-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Molecular evolution and balancing selection in the flavin-contatining monooxygenase 3 gene (FMO3).2007
- Author(s)
  Allerston, C.K.・Shimizu, M.・Fujieda, M.・Shephard, E.A.・Yamazaki, H.・Phillips, I.R.
- Journal Title
  
  Pharmacogenet.Genomics 17
  
  Pages: 827-839
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Effect of genetic variants of the human falvin-containing monooxygenase 3 (FMO3) on N-and S-oxygenation activities.2007
- Author(s)
  Shimizu, M.・Yano, H.・Nagashima, S.・Murayama, N.・Zhang, J.・Cashman, J.R.・Yamazaki, H.
- Journal Title
  
  Drug Metab. Dispos. 35
  
  Pages: 328-330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Stop codon mutations in the flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population.2007
- Author(s)
  Yamazaki, H・Fujita, H・Gunji, T・Zhang, Z・Kamataki, T・Cashman, JR・Shimizu, M.
- Journal Title
  
  Mol. Genet. Metab. 90
  
  Pages: 58-63
- NAID
  120000971644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Rat cytochrome P450 2C11 in liver microsomes involved in oxidation of anesthetic agent propofol and deactivated by prior treatment with propofol2006
- Author(s)
  Yamazaki, H., Shimizu, M., Nagashima, T., Minoshima, M., Murayama, N., Drug Metab.Dispos.
- Journal Title
  
  Drug Metab. Dispos 34
  
  Pages: 1803-1805
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Rat cytochrome P450 2C11 in liver microsomes involved in oxidation of anesthetic agent propofol and deactivated by prior treatment with propofol2006
- Author(s)
  Yamazaki, H., Shimizu, M., Nagashima, T., Minoshima, M. and Murayama, N. Drug Metab.Dispos.
- Journal Title
  
  Drug Metab.Dispos 34
  
  Pages: 1803-1805
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Journal Article] Inter-individual variations of flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors
- Author(s)
  Nagashima, S., Shimizu, M., Yano, H., Murayama, N., Kumai, T., Kobayashi, S., Guengerich, F.P., and Yamazaki, H.
- Journal Title
  
  Drug Metab.Pharmacokin (in press)
- NAID
  10025723470
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Journal Article] Three novel single nucleotide polymorphisms (SNPs) of the FMO3 gene in a Japanese population.
- Author(s)
  Shimizu, M.et al.
- Journal Title
  
  Drug Metab Pharmacokinet. (In press)
- Data Source
  KAKENHI-PROJECT-17659038
[Journal Article] Effect of genetic variants of the human flavin-containing monooxygenase 3 (FMO3) on N- and S-oxygenation activities
- Author(s)
  Shimizu, M., Yano, H., Nagashima, S., Murayama, N., Zhang, J., Cashman, J.R. and Yamazaki, H
- Journal Title
  
  Drug Metab. Dispos 35
  
  Pages: 328-330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] 簡易生理学的薬物動態モデルによるチトクロム P450 3A4/5 遺伝子多型患者でのアトルバスタチンおよびカルバマゼピン血中動態予測2023
- Author(s)
  佐藤翼、安達昂一郎、村山典恵、清水万紀子、田中庸一、斎藤嘉朗、山崎浩史
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] シトクロムP450 2D6遺伝子多型を考慮したアトモキセチンおよびその4-水酸化体と脱メチル体代謝物のヒト体内動態予測2023
- Author(s)
  清水万紀子、上原正太郎、大山勝宏、田中庸一、齋藤嘉朗、末水洋志、吉田　さやか、山崎浩史
- Organizer
  第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-23K06217
[Presentation] 物質のヒト体内動態を規定する生理学的薬物動態モデル重要パラメータの予測と消化管吸収性推定の精緻化2022
- Author(s)
  神矢佑輔、佐藤翼、森國紗帆、内海正義、三浦智徳、村山典恵、清水万紀子、半田健太郎、北島正人、庄野文章、山崎浩史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07139
[Presentation] 東北メディカル・メガバンク統合データベースより見出した新規フラビン含有モノオキシゲナーゼ3 遺伝子変異の酵素機能に及ぼす影響2022
- Author(s)
  清水万紀子、巻口美晶、中村友里愛、菱沼英史、齋藤さかえ、平塚真弘、山崎浩史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] 物質のヒト体内動態を規定する生理学的薬物動態モデル重要パラメータの予測と消化管吸収性推定の精緻化2022
- Author(s)
  神矢佑輔、佐藤翼、森國紗帆、内海正義、三浦智徳、村山典恵、清水万紀子、半田健太郎、北島正人、庄野文章、山崎浩史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] 創薬候補品のpH依存的N-酸化反応に対するフラビン含有酸素添加酵素の寄与予測2021
- Author(s)
  谷口　友美、加藤　望、加藤　晴敏、久米　俊行、清水万紀子、山崎　浩史
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] 創薬候補品のpH依存的N-酸化反応に対するフラビン含有酸素添加酵素の寄与予測2021
- Author(s)
  谷口　友美、加藤　望、加藤　晴敏、久米　俊行、清水万紀子、山崎　浩史
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] フラビン含有酸素添加酵素が関わる薬物体内動態の個人差と相互作用2021
- Author(s)
  清水万紀子、山崎浩史
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] ネコ、イヌ、ブタにおけるフラビン含有モノオキシゲナーゼの同定・解析2021
- Author(s)
  宇野泰広、清水万紀子、小川友里衣、藤井優哉、山崎浩史
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] Primary oxidative metabolites of Thalidomide in rat and humanized-liver mouse pharmacokinetics2021
- Author(s)
  Hiroshi Yamazaki, Shotaro Uehara, Makiko Shimizu, Hiroshi Suemizu
- Organizer
  24th North American ISSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07164
[Presentation] 日常生活下日本人の動脈硬化症指標とチトクロム P450 2A6 遺伝子型の関連2020
- Author(s)
  清水万紀子、水垣亜美、浦岡未来、桑島愛生、牟礼佳苗、山崎浩史
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] アルプラゾラムと口キソプ口フェンの誤飲が疑われた1歳児における薬物動態分析2020
- Author(s)
  田中敏博，清水万紀子，山崎浩史
- Organizer
  第41回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] Hepatic and renal concentrations of general chemicals estimated after virtual oral administrations extrapolated using simple physiologically based pharmacokinetic models and rat plasma data2020
- Author(s)
  Hiroshi Yamazaki and Makiko Shimizu
- Organizer
  SOT 59th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] Drug interactions mediated by flavin-containing monooxygenase in humanized-liver mice2019
- Author(s)
  Makiko Shimizu, Shotaro Uehara, Hiroshi Suemizu, Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] 肝毒性予測のため薬物動態モデル2019
- Author(s)
  山崎浩史、北島正人、清水万紀子
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K07205
[Presentation] Hepatic concentrations of chemicals after virtual oral administrations extrapolated using rat plasma data and simple physiologically based pharmacokinetic models2019
- Author(s)
  Hiroshi Yamazaki, Makiko Shimizu
- Organizer
  SOT 58th Annual Meeting and ToxExpo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] 肝毒性予測のため薬物動態モデル2019
- Author(s)
  山崎浩史、北島正人、清水万紀子
- Organizer
  第46回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] Genetic Polymorphisms of Flavin-containing Monooxygenase 3 Gene in Japanese Cohorts2018
- Author(s)
  Makiko Shimizu, Komei Nakakuki, Hiromi Yoda, Masahiro Hiratsuka, and Hiroshi Yamazaki
- Organizer
  2018 International Meeting on 22nd MDO and 33rd JSSX
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] Human plasma and urinary metabolic profiles of trimethylamine and its N-oxide extrapolated using humanized-liver mice and simple physiologically based pharmacokinetic models2018
- Author(s)
  Hiroshi Yamazaki, Hiroshi Suemizu, and Makiko Shimizu
- Organizer
  SOT 57th Annual Meeting and ToxExpo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] Human plasma and urinary metabolic profiles of trimethylamine and its N-oxide extrapolated using humanized-liver mice and simple physiologically based pharmacokinetic models2018
- Author(s)
  Hiroshi Yamazaki, Hiroshi Suemizu, and Makiko Shimizu
- Organizer
  SOT 57th Annual Meeting and ToxExpo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08425
[Presentation] Mutations of flavin-containing monooxygenase 3 (FMO3) gene in Japanese cohorts2018
- Author(s)
  Makiko Shimizu, Komei Nakakuki, Hiromi Yoda, Masahiro Hiratsuka, and Hiroshi Yamazaki
- Organizer
  22nd North American ISSX Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] 東北メディカル・メガバンク統合データベースより見出された新規フラビン含有モノオキシゲナーゼ3 遺伝子変異の組換え酵素を用いた機能解析2018
- Author(s)
  中莖昂明、清水万紀子、菱沼英史、平塚真弘、山崎浩史
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] ヒト肝細胞移植マウスの薬物血中濃度および生理学的薬物動態モデルを組み合わせたヒト薬物血中濃度推移予測2017
- Author(s)
  三井満里奈、清水万紀子、山崎美穂、末水洋志、山崎浩史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県、仙台市)
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] 日本人トリメチルアミン尿症の一因となる新規フラビン含有モノオキシゲナーゼ3変異型酵素の触媒機能2017
- Author(s)
  清水万紀子、依田紘美、五十嵐成美、武井まどか、中莖昂明、山崎浩史
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県、仙台市)
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] Metabolic Profiles of Benzydamine in Humanized-liver Mice2017
- Author(s)
  Makiko Shimizu, Hiroshi Suemizu, and Hiroshi Yamazaki
- Organizer
  21st North American ISSX Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] 日本人におけるトリメチルアミン尿症の原因となる新規フラビン含有モノオキシゲナーゼ3遺伝子変異の解析2016
- Author(s)
  徳山瑛美、清水万紀子、牧野美紀、梶谷綾、渡邊碧、山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Activation of thalidomide to reactive metabolites by autoinduced human cytochrome P450 3A enzymes with substrate cooperativity2016
- Author(s)
  Hiroshi Yamazaki, Makiko Shimizu
- Organizer
  The 21st International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  Davis, California, USA
- Year and Date
  2016-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460206
[Presentation] Drug Oxidations Mediated by Polymorphic Flavin-Containing Monooxygenase2016
- Author(s)
  Shimizu, M., and Yamazaki, H.
- Organizer
  The 21st International Symposium on Microsomes and Drug Oxidations
- Place of Presentation
  USA, California, UC Davis Conference Centre
- Year and Date
  2016-10-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] フラビン含有酸素添加酵素およびチトクロム P450 の共通基質ベンジダミンのヒト肝移植マウスを用いた in vivo 血中動態予測2016
- Author(s)
  清水万紀子、末水洋志、三井満里奈、山崎美穂、山崎浩史
- Organizer
  第37回日本臨床薬理学会学術総会
- Place of Presentation
  米子コンベンションセンター (鳥取県　米子市）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-16K08380
[Presentation] 日本人におけるトリメチルアミン尿症の一因となる新規フラビン含有モノオキシゲナーゼ3ハプロタイプの解析2016
- Author(s)
  牧野美紀、清水万紀子、徳山瑛美、梶谷綾、渡邊碧、山崎浩史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜、パシフィコ横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] 日本人のトリメチルアミン尿症に関する大規模調査2015
- Author(s)
  千葉布季子、清水万紀子、牧野美紀、三觜菜々子、友田沙也加、山崎浩史
- Organizer
  第69回聖マリアンナ医科大学医学会学術集会
- Place of Presentation
  川崎、聖マリアンナ医科大学
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Flavin-containing monooxygenase 3: Individual differences and drug interactions2015
- Author(s)
  Makiko Shimizu, Hiroshi Yamazaki
- Organizer
  30th JSSX Annual Meeting
- Place of Presentation
  東京、江戸川区民センター
- Year and Date
  2015-11-12
- Invited
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Mutations of flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria2015
- Author(s)
  Makiko Shimizu, Hiroshi Yamazaki
- Organizer
  19th International Conference on Cytochrome P450
- Place of Presentation
  東京、国立オリンピック記念青少年総合センター
- Year and Date
  2015-06-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] 日本人トリメチルアミン尿症の大規模詳細調査2015
- Author(s)
  千葉布季子、清水万紀子、徳山瑛美、牧野美紀、山崎浩史
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸　（兵庫県）
- Year and Date
  2015-03-27
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Non-P450 drug-metabolizing enzyme flavin-containing monooxygenase: polymorphisms and interactions2015
- Author(s)
  Makiko Shimizu
- Organizer
  30th JSSX Annual Meeting
- Place of Presentation
  東京、江戸川区民センター
- Year and Date
  2015-11-12
- Invited
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] 日本人のトリメチルアミン尿症の一因となるフラビン含有モノオキシゲナーゼ3遺伝子変異の解析2014
- Author(s)
  伊熊鞠佳、清水万紀子、三觜菜々子、友田沙也加、山崎浩史
- Organizer
  第68回聖マリアンナ医科大学医学会学術集会
- Place of Presentation
  聖マリアンナ医科大学（神奈川県川崎市）
- Year and Date
  2014-12-10
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Genetic polymorphisms in flavin-containing monooxygenase 3 (FMO3) gene responsible for trimethylaminuria in a Japanese population2014
- Author(s)
  Makiko Shimizu, Hiroshi Yamazaki
- Organizer
  19th North American ISSX / 29th JSSX Meeting
- Place of Presentation
  Hilton San Francisco Union Square Hotel（サンフランシスコ、米国）
- Year and Date
  2014-10-21
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] レボカルニチン投与時の透析患者におけるトリメチルアミンおよび N-酸化体の体内運命の検討2014
- Author(s)
  小泉綾乃、若林あかり、清水万紀子、小篠榮、山崎浩史
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  昭和薬科大学（東京都）
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] 日本人集団から見出されたトリメチルアミン尿症の原因となるフラビン含有酸素添加酵素3遺伝子多型2014
- Author(s)
  清水万紀子、折口裕美、伊熊鞠佳、三觜菜々子、友田沙也加、山崎浩史
- Organizer
  第35回日本臨床薬理学会学術総会
- Place of Presentation
  愛媛看護研修センター（愛媛）
- Year and Date
  2014-12-04
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] ヒトフラビン含有酸素添加酵素 3 が関与する薬物相互作用2013
- Author(s)
  清水万紀子、佐藤歩、白石有紗、村山典恵、山崎浩史
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2013-03-30
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] ヒト及びサル肝P450に認められるワルファリン代謝の立体選択性2013
- Author(s)
  村山典恵、宇野泰広、細井祥生、岩崎一秀、清水万紀子、鵜藤雅裕、山崎浩史
- Organizer
  日本学学会第133年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] P4503A4タンパク発現量および薬物代謝酵素活性におよぼすCYP3A4:22遺伝子多型の影響2013
- Author(s)
  大久保真穂、村山典恵、清水万紀子、山崎浩史
- Organizer
  日本学学会第133年会
- Place of Presentation
  パシフィコ横浜(神奈川)
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] フラビン含有モノオキシゲナーゼが触媒する薬物酸化酵素活性のヒトと実験動物の種差2013
- Author(s)
  山崎美穂、清水万紀子、宇野泰広、小林由布子、村山典恵、岩崎一秀、鵜藤雅裕、山崎浩史
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2013-03-30
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] チオカルバメート系除草剤モリネートの代謝消失における種差の検討2012
- Author(s)
  村山典恵、山下真直、塚田藍、末水洋志、中村雅登、高野良治、清水万紀子、山崎浩史
- Organizer
  日本薬学会第132回年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] チオカルバメート系除草剤モリネートの代謝消失における種差の検討2012
- Author(s)
  村山典恵、山下真直、塚田藍、高野良治、末水洋志、中村雅登、清水万紀子、山崎浩史
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌市・北海道大学・高等教育推進機構
- Year and Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] 日本人集団において見出されたトリメチルアミン尿症に関わるフラビン含有酸素添加酵素の遺伝子多型2012
- Author(s)
  清水万紀子, 小林由布子, 山崎美穂, 石井有紀, 加瀬愛幸, 山崎浩史
- Organizer
  第33回日本臨床薬理学会年会
- Place of Presentation
  沖縄コンベンションセンター(宜野湾市)
- Year and Date
  2012-11-29
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] 肝試料画分を考慮した化学物質のヒト生理学的薬物動態モデルの精緻化2011
- Author(s)
  村山典恵、國兼絵里子、塚田藍、高野良治、北島正人、清水万紀子、池田敏彦、山崎浩史
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] 日本人集団におけるトリメチルアミン尿症の大規模調査2011
- Author(s)
  清水万紀子, 佐藤歩, 徳元久乃, 沼尾恵里, 村山典恵, 山崎浩史
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  アクトシティ浜松(浜松市)
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] ヒトフラビン含有モノオキシゲナーゼ 3 が関与する薬物相互作用2011
- Author(s)
  佐藤歩、清水万紀子、白石有紗、永島里美、村山典恵、山崎浩史
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  東邦大学習志野キャンパス(船橋市)
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] Drug Interaction of Thalidomide with Midazolam in Human Hepatoma Cell Line System with Differentiated HepaRG Cryopreserved2011
- Author(s)
 Norie Murayama, Kanako Yajima, Makiko Shimizu, Masahiro Utoh, Hiroshi Yamazaki
- Organizer
 17^<th> Notth America ISSX Meeting
- Place of Presentation
 Atranta, USA, Hotel Hirtone
- Year and Date
 2011-10-17
- Data Source
 KAKENHI-PROJECT-21590177
[Presentation] 日本人トリメチルアミン尿症の大規模実態調査2011
- Author(s)
  清水万紀子、小林由布子、佐藤歩、徳元久乃、沼尾恵里、小園真里恵、村山典恵、山崎浩史
- Organizer
  日本薬学会第131回年会(要旨集上にて発表)
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-21790160
[Presentation] Drug metabolism in human hepatomacell line system with differentiated HepaRG cryopreserved2011
- Author(s)
  Norie Murayama, Kanako Yajima, Makiko Shimizu, Masahiro Utoh, and Hiroshi Yamazaki
- Organizer
  26th JSSX Annual Meeting
- Place of Presentation
  広島
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] ヒトフラビン含有モノオキシゲナーゼ3 が関与する薬物相互作用2011
- Author(s)
  佐藤　歩、清水万紀子、白石有紗、永島里美、村山典恵、山崎　浩史
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  東邦大学習志野キャンパス (千葉)
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] トリメチルアミン尿症の一因となるフラビン含有モノオキシゲナーゼ3遺伝子変異の酵素機能解析2011
- Author(s)
  林祥子, 清水万紀子, 村山典恵, 山崎浩史
- Organizer
  第61回聖マリアンナ医科大学医学会
- Place of Presentation
  聖マリアンナ医科大学 (神奈川)
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] Intra- and inter-individual variations in metabolic capacity of flavin-containing monooxygenase 3 in childhood2011
- Author(s)
  Makiko Shimizu, Marie Kozono, Yuko Kobayashi, Ayumi Sato, Norie Murayama, and Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島国際会議場 (広島市)
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] 野生型および変異型フラビン含有モノオキシゲナーゼ 3 を介した薬物相互作用2011
- Author(s)
  白石有紗, 清水万紀子, 永島里美, 村山典恵, 山崎浩史
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2011-07-07
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] マルチプレックスPCR法を用いたフラビン含有モノオキシゲナーゼ3遺伝子多型判定法の確立2011
- Author(s)
  池田恵理奈、清水万紀子、徳元久乃、村山典恵、山崎浩史
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  東邦大学習志野キャンパス (千葉)
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] 日本人喫煙者の生体内ニコチン代謝物濃度の個人差2011
- Author(s)
  永野卓、清水万紀子、清谷一馬、鎌滝哲也、松本史彦、村山典恵、山崎浩史
- Organizer
  日本薬学会第131回年会(要旨集上にて発表)
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-21790160
[Presentation] Drug Metabolism In Human Hepatoma Cell Line System with Differentiated HepaRG Cryopresorved2011
- Author(s)
  Norie Murayama, Kanako Yajima, Makiko Shimizu, Masahiro Utoh, Hiroshi Yamazaki
- Organizer
  JSSX
- Place of Presentation
  広島市・国際会議場
- Year and Date
  2011-11-22
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] 日本人トリメチルアミン尿症に関わるフラビン含有モノオキシゲナーゼ 3 遺伝子変異の探索2011
- Author(s)
  小林由布子, 清水万紀子, 林祥子, 村山典恵, 山崎浩史
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  アクトシティ浜松(浜松市)
- Year and Date
  2011-12-01
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] Intra- and inter-individual variations in metabolic capacity of flavin-containing monooxygenase 3 in childhood2011
- Author(s)
  Makiko Shimizu, Marie Kozono, Yuko Kobayashi, Ayumi Sato, Norie Murayama, and Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第26回年会
- Place of Presentation
  広島国際会議場(広島)
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] 野生型および変異型フラビン含有モノオキシゲナーゼ3を介した薬物相互作用2011
- Author(s)
  白石有紗, 清水万紀子, 永島里美, 村山典恵, 山崎浩史
- Organizer
  第38回日本トキシコロジー学会学術年会
- Place of Presentation
  パシフィコ横浜 (神奈川)
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] マルチプレックス PCR 法を用いたフラビン含有モノオキシゲナーゼ 3遺伝子多型判定法の確立2011
- Author(s)
  池田恵理奈、清水万紀子、徳元久乃、村山典恵、山崎浩史
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  東邦大学習志野キャンパス(船橋市)
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] 日本人トリメチルアミン尿症に関わるフラビン含有モノオキシゲナーゼ3遺伝子変異の探索2011
- Author(s)
  小林由布子, 清水万紀子, 林祥子, 村山典恵, 山崎浩史
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  アクトシティ浜松(静岡)
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] トリメチルアミン尿症の一因となるフラビン含有モノオキシゲナーゼ 3 遺伝子変異の酵素機能解析2011
- Author(s)
  林祥子, 清水万紀子, 村山典恵, 山崎浩史
- Organizer
  第61回聖マリアンナ医科大学医学会
- Place of Presentation
  第61回聖マリアンナ医科大学医学会
- Year and Date
  2011-07-22
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] 日本人集団におけるトリメチルアミン尿症の大規模調査2011
- Author(s)
  清水万紀子, 佐藤歩, 徳元久乃, 沼尾恵里, 村山典恵, 山崎浩史
- Organizer
  第32回日本臨床薬理学会年会
- Place of Presentation
  アクトシティ浜松(静岡)
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] 肝試料画分を考慮した化学物質のヒト生理学的薬物動態モデルの精緻化2011
- Author(s)
  村山典恵、國兼絵里子、塚田藍、高野良治、北島正人、清水万紀子、山崎浩史
- Organizer
  日本薬学会第131年会
- Place of Presentation
  要旨集上にて発表
- Year and Date
  2011-03-05
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] Drug interactions of thalidomide with midazolam in human hepatoma cell line system with differentiated HepaRG cryopreserved2011
- Author(s)
  Norie Murayama, Kanako Yajima, Makiko Shimizu, Masahiro Utoh, and Hiroshi Yamazaki
- Organizer
  17 th North American regional ISSX meeting
- Place of Presentation
  Atlanta, USA
- Year and Date
  2011-10-18
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] 成長に伴う酸素添加酵素フラビン含有モノオキシゲナーゼの個人内・個人間変動2010
- Author(s)
  清水万紀子、小園真里恵、村山典恵、J.Steven Leeder、山崎浩史
- Organizer
  第31回日本臨床薬理学会年会
- Place of Presentation
  京都
- Year and Date
  2010-12-02
- Data Source
  KAKENHI-PROJECT-21790160
[Presentation] 日本人ボランティアにおけるフラビン含有モノオキシゲナーゼ3の解析2010
- Author(s)
  清水万紀子、青木悠佳、井萱翔、池田恵理奈、白石有紗、林祥子、村山典恵、山崎浩史
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21790160
[Presentation] トリメチルアミン代謝に影響するフラビン含有モノオキシゲナーゼ3含量の変化2010
- Author(s)
  小園真里恵、清水万紀子、村山典恵、山崎浩史
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21790160
[Presentation] Bonitos as palliative care for Japanese trimethylaminuria subjects2010
- Author(s)
  Makiko Shimizu, Marie Kozono, Norie Murayama, Hiroshi Yamazaki
- Organizer
  25th JSSX Annual Meeting
- Place of Presentation
  埼玉
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-21790160
[Presentation] Individual differences in pharmacokinetics and pharmacodynamics of anesthetic agent propofol in patients genotyped for CYP2B6 and UGT1A92010
- Author(s)
  Hiroshi Yamazaki, Toshio Kumai, Kuniharu Sasaki, Makito Yokozuka, Makiko Shimizu, Tadashi Tateda, Norie Murayama and Shinichi Kobayashi
- Organizer
  ISSX Workshop on Genetic Polymorphisms in Drug Disposition
- Place of Presentation
  Indianapolis, USA
- Year and Date
  2010-04-11
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] 喫煙者血中濃度領域でのニコチン酸化的代謝に関与する薬物代謝酵素2010
- Author(s)
  永野卓、清水万紀子、村山典恵、山崎浩史
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21790160
[Presentation] ヒトと実験動物間で認められる薬物代謝酵素機能の種差2010
- Author(s)
  村山典恵, 今村裕樹, 大久保真穂, 國兼絵里子, 松本史彦, 小野瀬優維, 佐々木国玄, 清水万紀子, 山崎浩史
- Organizer
  日本薬学会第130回総会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] タバコ煙曝露量予測のための日本人喫煙者バイオモニタリング2010
- Author(s)
  永野卓、清水万紀子、堀内佳奈、村山典恵、庄野文章、山崎浩史
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21790160
[Presentation] Bonitos as palliative care for Japanese trimethylaminuria subjects.2010
- Author(s)
  Makiko Shimizu, Marie Kozono, Norie Murayama, Hiroshi Yamazaki
- Organizer
  25rd JSSX Annual Meeting
- Place of Presentation
  さいたま市大宮ソニックシティ
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-21790160
[Presentation] 成長に伴うフラビン含有モノオキシゲナーゼ3代謝効率の変化2010
- Author(s)
  小園真里恵、清水万紀子、村山典恵、山崎浩史
- Organizer
  第54回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2010-10-02
- Data Source
  KAKENHI-PROJECT-21790160
[Presentation] 日本人のフラビン含有モノオキシゲナーゼ3(FMO3)ハプロタイプの解析2009
- Author(s)
  清水万紀子、永島里美、村山典恵、山崎浩史
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] Flavin-containing monooxygenase 3 (FMO3) haplotypes in a Japanese population2009
- Author(s)
  Makiko Shimizu, Charles K.Allerston, Marie Kozono, Norie Murayama, Ian R. Phillips, Hiroshi Yamazaki
- Organizer
  24th JSSX Annual Meeting
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21790160
[Presentation] Flavin-containing monooxygenase 3 (FMO3) haplotypes in a Japanese population2009
- Author(s)
  Shimizu M., Allerston C.K., Kozono M., Murayama N., Phillips I.R, Yamazaki H.
- Organizer
  24rd JSSX Annual Meeting
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21790160
[Presentation] フラビン含有モノオキシゲナーゼ3変異酵素の医薬品参加酵素活性2009
- Author(s)
  永島里美、清水万紀子、村山典恵、山崎浩史
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] Impact of genetic polymorphism of the CYP3A5 appeared in the metabolism of and inhibition by voriconazoke in a Japanese population2009
- Author(s)
  村山典恵, 清水万紀子, 山崎浩史
- Organizer
  日本薬物動態学会
- Place of Presentation
  京都
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] 日本人におけるトリメチルアミン尿症の一因となるフラビン含有モノオキシゲナーゼ3の遺伝子変異の研究2009
- Author(s)
  青木悠佳, 清水万紀子, 小園真里恵, 村山典恵, 山崎浩史
- Organizer
  第53回日本薬学会関東支部大会
- Place of Presentation
  埼玉
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-21790160
[Presentation] Impact of cytochrome p450 3A5 expression in human livers on drug interactions of anti-fungal agents with midazolam2009
- Author(s)
  村山典恵, 中本美那子, 清水万紀子, 山崎浩史
- Organizer
  16th International Conference on Cytochrome P450 ～Biochemistry, Biophysics, Biotechnology～
- Place of Presentation
  沖縄
- Year and Date
  2009-06-21
- Data Source
  KAKENHI-PROJECT-21590177
[Presentation] アゾール系抗真菌薬の阻害効果とCYP3A5遺伝子多型との関連性2009
- Author(s)
  村山典恵、中本実那子、岡田雄介、清水万紀子、山崎浩史
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Analysis of Suppression and activation of the haplotyped flavin-containing monooxygenase 3 (FMO3) Gene Transcriptions in Japanese2008
- Author(s)
  Makiko Shimizu, Norie Murayama, Satomi Nagashima, Masaki Fujieda, and Hiroshi Yamazaki
- Organizer
  2nd Asia Pacific ISSX Meeting 2008
- Place of Presentation
  Shanghai, China
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] INDIVIDUAL DIFFERENCES OF OXIDATIVE METABOLISM OF MEDICINES AND THEIR CLINICAL SIGNIFICANCE2008
- Author(s)
  Hiroshi Yamazaki, ^a Dimitrios Zonios, ^b Makiko Shimizu, ^a John Bennett, ^b Norie Murayama
- Organizer
  Pan-Pacific International Partnership Conference on Pharm aceutical and Life Sciences The 4th US-Japan Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] レポーターアッセイを用いたFMO3遺伝子の転写調節機構2008
- Author(s)
  清水万紀子, 永島里美, 村山典恵, 山崎浩史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝チトクロームP450触媒活性に及ぼすサリドマイドの影響2008
- Author(s)
  村山典恵, 柳田千裕, 清水万紀子, 山崎浩史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Inhibitory effects of thalidomide on human liver microsomal Cytochrome P450-mediated drug oxidation activities2008
- Author(s)
  Norie, Murayama, Chihiro, Yanagida, Makiko, Shimizu, Hiroshi, Yamazaki
- Organizer
  128th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] INDIVIDUAL DIFFERENCES OF OXIDATIVE METABOLISM OF MEDICINES AND THEIR CLINICAL SIGNIFICANCE2008
- Author(s)
  Hiroshi, Yamazaki, Dimitrios, Zonios, Makiko, Shimizu, John, Bennett, Node, Murayama
- Organizer
  Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences The 4th US-Japan Joint Conference
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Individual differences of levels of voriconazole and its oxidative metabolites in patients2008
- Author(s)
  Node, Murayama, Dimitrios, Zonios, Makiko, Shimizu, John, Bennett, Hiroshi, Yamazaki
- Organizer
  128th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] レポーターアッセイを用いたヒトFMO3遺伝子の転写調節機構の解析2008
- Author(s)
  清水万紀子,永島里美,村山典惠,山崎浩史
- Organizer
  日本薬学会第127回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] INDIVIDUAL DIFFERENCES O FOXIDATIVEME TABOLISM OF MEDICINES AND THEIR CLINICAL SIGNIFICANCE2008
- Author(s)
  Hiroshi Yamazaki, ^a DimitriosZonios, ^b MakikoShimizu, ^a JohnBennett, ^b NorieMurayama
- Organizer
  Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences The 4th US-Japan Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝チトクロームP450触媒活性に及ぼすサリドマイドの影響2008
- Author(s)
  永島里美, 清水万紀子, 村山典恵, 山崎浩史
- Organizer
  目本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝におけるフラビン含有モノオキシゲナーゼ3発現量の個人差の解析2008
- Author(s)
  永島里美, 清水万紀子, 村山典恵, 山崎浩史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝チトクロームP450触媒活性に及ぼすサリドマイドの影響2008
- Author(s)
  村山典恵、柳田千裕、清水万紀子、山崎浩史
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] 抗真菌薬ボリコナゾールの酸化的代謝物生成の個人差について2008
- Author(s)
  山崎浩史, 清水万紀子, 村山典恵
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] INDIVIDUAL DIFFERENCES OF OXIDATIVE METABOLISM OF MEDICINES AND THEIR CLINICAL SIGNIFICANCE2008
- Author(s)
  Hiroshi Yamazaki, a Dimitrios Zonios, b Makiko Shimizu, a John Bennett, b Norie Murayama
- Organizer
  Pan-Pacific International Partnership Conference on Pharm aceutical and Life Sciences The 4th US-Japan Joint Conference
- Place of Presentation
  名古屋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒト肝チトクロムP450による全身麻酔薬プロポフォールの代謝について2008
- Author(s)
  中本実那子、村山典恵、簑島正樹、清水万紀子、山崎浩史
- Organizer
  医療薬学フォーラム2008 第16回クリニカルファーマシーシンポジウム
- Place of Presentation
  船橋
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] ヒト肝チトクロムP450による全身性麻酔薬プロポフォールの代謝について2008
- Author(s)
  中本実那子, 村山典恵, 簑島正樹, 清水万紀子, 山崎浩史
- Organizer
  医療薬学フォーラム2008
- Place of Presentation
  船橋
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Analysis of transcriptional regulation of the human flavin-containing monooxygenase 3(FMO3) gene using the reporter assay Individual differences of flavin-containing monooxygenase S(FMO3) expression levels in human livers2008
- Author(s)
  Makiko, Shimizu, Satomi, Nagashima, Norie, Murayama, Hiroshi, Yamazaki
- Organizer
  128th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] トリメチルアミン尿症が疑われる日本人の対症療法の検討、医療薬学フォーラム20082008
- Author(s)
  清水万紀子、野村里香、小園真里恵、永島里美、村山典恵、山崎浩史
- Organizer
  第16回クリニカルファーマシーシンポジウム
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] ヒト肝におけるフラビン含有モノオキシゲナーゼ3発現量の個人差の解析2008
- Author(s)
  永島里美,清水万紀子,矢野裕士,村山典惠,山崎浩史
- Organizer
  日本薬学会第127回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] Voriconazole methyl hydroxylation and N-oxidation catalyzed by CYP3A4 and CYP2C19 in human liver microsomes2008
- Author(s)
  Hiroshi, Yamazaki, Node, Murayama, Naoko, Imai, Takahisa, Nakane, Makiko, Shimizu
- Organizer
  128th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Individual Difference of Flavin-Containing Monooxygenase3 in Human Livers2008
- Author(s)
  Shimizu, M., Nagashima, S., Murayama, N., and Yamazaki, H
- Organizer
  23rd JSSX Annual Meeting
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] Catalitic activities of the flavin-containing monooxygenase 3 (FMO3) variants found in Japanese2008
- Author(s)
  Satomi Nagashima, Makiko Shimizu, Hiroshi Yano, Norie Murayama, and Hiroshi Yamazaki
- Organizer
  Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] Makiko Shimizu, Satomi Nagashima, Norie Murayama, Hiroshi Yamazaki2008
- Author(s)
  Makiko Shimizu, Satomi Nagashima, Norie Murayama, Hiroshi Yamazaki
- Organizer
  23rd JSSX Annual Meeting
- Place of Presentation
  kumamoto
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] Expression levels and catalytic activities of flavin-containing monooxygenase 3 in Japanese and Caucasian livers2008
- Author(s)
  Makiko Shimizu, Satomi Nagashima, Norie Murayama, Hiroshi Yamazaki
- Organizer
  International Society for the Study of Xenobiotics 15th North American Regional Meeting
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] 全身性麻酔薬プロポフォールの酸化的代謝における個人差2008
- Author(s)
  中本実那子、村山典恵、神作文康、柏田雅也、簑島正樹、清水万紀子、山崎浩史
- Organizer
  第29回日本臨床薬理学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] アゾール系抗真菌薬の薬物酸化的代謝に及ぼす影響2008
- Author(s)
  中本実那子、村山典恵、清水万紀子、山崎浩史
- Organizer
  第56回聖マリアンナ医学会学術集会
- Place of Presentation
  川崎
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] "Micromini" Pigs as a Possible New Animal Model For Humans in Non-Clinical Study2008
- Author(s)
 Norie Murayama, Naoki Kaneko, Kana Horiuchi, Makiko Shimizu, Katzuhiko Ito, and Hiroshi Yamazaki
- Organizer
 23^<rd> JSSX Annual Meeting
- Place of Presentation
 熊本
- Data Source
 KAKENHI-PROJECT-19591819
[Presentation] ヒト肝フラビン含有モノオキシゲナーゼ3発現に影響する因子の解析2008
- Author(s)
  永島里美、清水万紀子、矢野裕士、村山典恵、山崎浩史
- Organizer
  医療薬学フォーラム2008,第16回クリニカルファーマシーシンポジウム
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] Three novel single nucleotide polymorphisms of the flavin-containing monooxygenase 3(FMO3) gene in a Japanese population2007
- Author(s)
  Hiroshi, Yamazaki, Makiko, Shimizu
- Organizer
  127th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Node Murayama, Hiroshi Yamazaki Functional analysis of two novel flavin-containing monooxygenase 3 variants found in a Japanese population2007
- Author(s)
  Makiko, Shimizu, Hiroshi, Yano, Sachiko, Tomioka
- Organizer
  127th The Annual meeting of Pharmaceutical Society Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Genetic Polymorphism of the Flavin-Containing Moonooxygenase 3(FMO3) Associated with Trimethylaminuria in a Japanese Cohort2007
- Author(s)
  Shimizu, M.・Nagashima, S.・Murayama, N.・Yamazaki, H.
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] Genetic Polymorphism of the Flavin-Containing Monooxygenase 3(FMO3) Associatedwith Trimethylaminuria in a Japanese Cohort2007
- Author(s)
  Makiko Shimizu, Satomi Nagashima, Norie Murayama and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Oxygenation Activities of the Flavin-Containing Monooxygenase 3(FMO3) Variants Found in Japanese2007
- Author(s)
  Satomi Nagashima, Makiko Shimizu, Hiroshi Yano, Norie Murayama, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Metabolic pathway of anesthesic drug propofol in human liver microsomes2007
- Author(s)
  Node, Murayama, Masaki, Minoshima, Naoko, Imai, Makiko, Shimizu, Hiroshi, Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] 薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらすアミン化合物酸化的代謝の個人差に関する臨床薬理学研2007
- Author(s)
  山崎浩史、清水万紀子、永島里美、村山典惠
- Organizer
  28回日本臨床薬理学会年会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] Voriconazole methyl hydroxylation and N-oxidation catalyzed by CYP3A4 and CYP2C19 in human liver microsomes2007
- Author(s)
  Hiroshi Yamazaki, Norie Murayama, Naoko Imai, Takahisa Nakane, Makiko Shimizu
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] 薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらすアミン化合物酸化的代謝の個人差に関する臨床薬理学研究2007
- Author(s)
  山崎浩史, 清水万紀子, 永島里美, 村山典恵
- Organizer
  第28回日本臨床薬理学会年会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Genetic Polymorphism of the Flavin-Containing Monooxygenase 3 (FMO3) Associated with Trimethylaminuria in a Japanese Cohort2007
- Author(s)
  Makiko Shimizu, Satomi Nagashima, Norie Murayama and Hiroshi Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] Genetic polymorphism of the flavin-containing monooxygenase 3(FMO3) associated with trimethylaminuria in a Japanese Cohort2007
- Author(s)
  Makiko, Shimizu, Satomi, Nagashima, Node, Murayama, Hiroshi, Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] 全身性プロポフォールの覚醒遅延に関するヒト肝薬物代謝酵素の検討2007
- Author(s)
  村山典恵、簑島正樹、今井直子、清水万紀子、山崎浩史
- Organizer
  第127会日本薬学年会
- Place of Presentation
  富山
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Voriconazole methyl hydroxylation and N-oxidation catalyzed by CYP3A4 and CYP2C19 in human liver microsomes2007
- Author(s)
  Hiroshi Yamazaki, Norie Murayama, Naoko Imai, Takahisa Nakane, Makiko Shimizu
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Omega- and 4-Hydroxylation of the Anesthetic Agent Propofol Catalyzed by Human Liver Microsomal Cytochrome P450 2B62007
- Author(s)
  Norie Murayama , Masaki Minoshima, Makiko Shimizu, F.Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Guengerich, and Hiroshi Yamazaki Omega- and 4-Hydroxylation of the Anesthetic Agent Propofol Catalyzed by Human Liver Microsomal Cytochrome P450 2B62007
- Author(s)
  Node, Murayama, Masaki, Minoshima, Makiko, Shimizu, F., Peter
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Omega-and 4-Hydroxylation of the Anesthetic Agent Propofol Catalyzed by Human Liver Microsomal Cytochrome P450 2B62007
- Author(s)
  Norie Murayama, Masaki Minoshima, Makiko Shimizu, F.Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-19591819
[Presentation] Oxygenation Activities of the Flavin-Containing Monooxygenase 3 (FMO3) Variants Found in Japanese2007
- Author(s)
  Satomi Nagashima, Makiko Shimizu, Hiroshi Yano, Norie Murayama, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/ 8th ISSX meeting
- Place of Presentation
  Sendai
- Data Source
  KAKENHI-PROJECT-19790134
[Presentation] Omega- and 4-Hydroxylation of theAnesthetic Agent Propofol Catalyzed by HumanLiver Microsomal Cytochrome P450 2B62007
- Author(s)
  Norie Murayama, Masaki Minoshima, Makiko Shimizu, F.Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Omega- and 4-Hydroxylation of the Anesthetic Agent Propofol Catalyzed by Human Liver Microsomal Cytochrome P450 2B62007
- Author(s)
  Norie Murayama, Masaki Minoshima, Makiko Shimizu, F.Peter Guengerich, and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Genetic Polymorphism of the Flavin-Containing Monooxygenase 3(FMO3)Associated with Trimethylaminuria in a Japanese Cohort2007
- Author(s)
  Makiko Shimizu, Satomi Nagashima, Norie Murayama and Hiroshi Yamazaki
- Organizer
  22nd JSSX/8th ISSX meeting
- Place of Presentation
  仙台
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] Rat Cytochrome P450 2C11 Involved in Oxidation of Anesthetic Drug Propofol and Deactivated by Propofol in Liver Microsomes2006
- Author(s)
  Hiroshi, Yamazaki, Makiko, Shimizu, Takashi, Nagashima, Masaki, Minoshima, Node, Murayama
- Organizer
  21st JSSX meeting
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390034
[Presentation] ヒトフラビン含有酸素添加酵素3が関与する薬物相互作用
- Author(s)
  清水万紀子、佐藤歩、白石有紗、村山典恵、山崎浩史
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] Flavin-containing monooxygenase 3 (FMO3) genotype and phenotype in a Japanes e cohort
- Author(s)
  Makiko Shimizu, Elizabeth Shephard, Ian R. Phillips, Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  タワーホール船堀　(千葉県)
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] レボカルニチン投与時の透析患者におけるトリメチルアミンおよびN-酸化体の体内動態の検討
- Author(s)
  小泉綾乃、清水万紀子、若林あかり、村山典恵、小篠榮、山崎浩史
- Organizer
  第66回聖マリアンナ医科大学医学会学術集会
- Place of Presentation
  聖マリアンナ医科大学　(神奈川県川崎市)
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] 日本人トリメチルアミン尿症の一因となるフラビン含有酸素添加酵素3遺伝子多型
- Author(s)
  清水万紀子、加瀬愛幸、石井有紀、山崎美穂、山崎浩史
- Organizer
  第34回日本臨床薬理学会学術総会
- Place of Presentation
  東京国際フォーラム　(東京都)
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] 抗精神病薬オランザピン投与日本人患者における血漿中薬物濃度の個人差
- Author(s)
  大久保真穂、成田桃子、村山典恵、森田翔子、中村浩也、清水万紀子、秋元洋一、後藤晶子、○山崎浩史
- Organizer
  日本薬学会第135 回年会
- Place of Presentation
  神戸学院大学,兵庫医療大学(神戸市）
- Year and Date
  2015-03-25 – 2015-03-29
- Data Source
  KAKENHI-PROJECT-24590211
[Presentation] 日本人集団において見出されたトリメチルアミン尿症に関わるフラビン含有酸素添加酵素の遺伝子多型
- Author(s)
  清水万紀子, 小林由布子, 山崎美穂, 石井有紀, 加瀬愛幸, 山崎浩史
- Organizer
  第33回日本臨床薬理学会年会
- Place of Presentation
  沖縄コンベンションセンター（宜野湾市）
- Data Source
  KAKENHI-PROJECT-23790200
[Presentation] Polymorphic human flavin-containing monooxygenase 3 (FMO3)-mediated drug interactions
- Author(s)
  Makiko Shimizu and Hiroshi Yamazaki
- Organizer
  SOT 53rd Annual Meeting and ToxExpo
- Place of Presentation
  West and North Buildings at the Phoenix Convention Center (Phoenix, USA)
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] 成長に伴う薬物酸化酵素フラビン含有モノオキシゲナーゼの個人変動
- Author(s)
  清水万紀子、山崎浩史
- Organizer
  次世代を担う創薬・医療薬理シンポジウム2013
- Place of Presentation
  熊本大学薬学部（熊本）
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] ヒトフラビン含有酸素添加酵素3が関与する薬物相互作用
- Author(s)
  清水万紀子、佐藤歩、石井有紀、白石有紗、村山典恵、山崎浩史
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館　(熊本県)
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] Flavin-containing monooxygenase 3 (FMO3) haplotypes in aJapanese population
- Author(s)
  Makiko Shimizu, Elizabeth Shephard, IAN Phillips, Hiroshi Yamazaki
- Organizer
  ICCP450
- Place of Presentation
  The University of Washington（シアトル、米国）
- Data Source
  KAKENHI-PROJECT-25460198
[Presentation] フラビン含有モノオキシゲナーゼが触媒する薬物酸化酵素活性のヒトと実験動物の種差
- Author(s)
  山崎美穂、清水万紀子、宇野泰広、小林由布子、村山典恵、岩崎一秀、鵜藤雅裕、山崎浩史
- Organizer
  日本薬学会第133年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23790200

1. MURAYAMA Norie (90219949)

# of Collaborated Projects: 16 results

# of Collaborated Products: 98 results
2. YAMAZAKI Hiroshi (30191274)

# of Collaborated Projects: 16 results

# of Collaborated Products: 183 results
3. 岩野俊介 (80374560)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 宇野泰広 (90372276)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 鎌滝哲也 (00009177)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. 青山隆彦 (70384633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SUEMIZU Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. TAKEUCHI Masayoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. KIYOTANI Kazuma

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 上原正太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
11. 神矢佑輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. 上田忠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Makiko 清水 万紀子

SHIMIZU Makiko 清水 万紀子

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Functional analysis of flavin-containing monooxygenases using species differences and human polymorphisms in primary structuresPrincipal Investigator

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Evaluation for pharmacokinetics of chemicals mediated by flavin-containing monooxygenases using humanized animal modelsPrincipal Investigator

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Pharmacokinetics prediction of drugs in humans associated with flavin-containing monooxygenase dependent-oxygenations in livers and kidneys of animal modelsPrincipal Investigator

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Drug oxygenations and interactions mediated by polymorphic flavin-containing monooxygenasesPrincipal Investigator

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Developmental variations in metabolic capacity of flavin-containing monooxygenase 3 in childhoodPrincipal Investigator

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Shimizu Makiko 清水万紀子

SHIMIZU Makiko 清水万紀子

[Book] 先天代謝異常ハンドブック (第2 章トリメチルアミン尿症(魚臭症候群))2012

[Book] 先天代謝異常ハンドブック (第2章　トリメチルアミン尿症（魚臭症候群）)2012