Hashimoto Osamu 橋本統

… Alternative Names

橋本統ハシモトオサム

HASHIMOTO Osamu 橋本統

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Researcher Number	90317058
Other IDs
Affiliation (Current)	2025: 日本大学, 生物資源科学部, 教授
Affiliation (based on the past Project Information) *help	2025: 日本大学, 生物資源科学部, 教授 2022: 日本大学, 生物資源科学部, 教授 2021: 長浜バイオ大学, バイオサイエンス学部, 教授 2019: 北里大学, 獣医学部, 准教授 2007 – 2013: Kitasato University, 獣医学部, 講師 … More 2004 – 2005: 北里大学, 獣医畜産学部, 講師 2001 – 2002: Kitasato Univ. School of Veterinary Medicine and Animal Sciences Lecturer, 獣医畜産学部, 講師 2000 – 2001: 北里大学, 獣医畜産学部, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 42020:Veterinary medical science-related / Basic veterinary science/Basic zootechnical science / Basic veterinary science/Basic zootechnical science Except Principal Investigator Medical genome science / Applied animal science / Basic veterinary science/Basic zootechnical science / Basic veterinary science/Basic zootechnical science
Keywords	Principal Investigator 肥満 / トランスジェニックマウス / メタボリックシンドローム / TGF-β / エネルギー代謝 / インスリン感受性 / アクチビン / 代謝性疾患 / へパトカイン / ベージュ脂肪 … More / 褐色脂肪 / 肥満／糖尿病 / 代謝 / 脂肪肝 / 肝臓 / 精神疾患 / 行動 / 糖 / cDNAクローニング / フォリスタチン / インヒビン / 膵外分泌組織 / リコンビナント蛋白質 / アクチビンE / アクチビンC … More Except Principal Investigator 下垂体 / GnRH / 卵巣 / レセプター / K562 / アクチビン / インヒビン / ES細胞 / 移植・再生医療 / 遺伝子 / 発生・分化 / 細胞・組織 / iPS細胞 / 再生 / 分化 / 前駆細胞 / 肺 / 呼吸器 / 幹細胞 / 再生医学 / Signal Transduction / Pituitary Cell / TGF-β Superfamily / Receptor / Activin / Inhibin / TGF-β / リコンビナントIBP / インヒビン結合蛋白質 / K562細胞 / Smad / シグナル伝達 / 下垂体細胞 / TGF-βファミリー / hypothalamus- hypophysis-gonadal axis / mouse / spermatogenesis / diethylstilbestrol / Sex differentiation / Sex determination / Endcrine disrupter chemicals / 脳-下垂体-性腺系 / 内分泌撹乱化学物質 / マウス新生子 / 視床下部-下垂体-性腺系 / 生殖腺細胞 / ジエチルスチルベステロール(DES) / 性分化 / 内分泌攪乱化学物質 / アネキシンA5 / アネキシンＡ５ / 乳腺 / 前立腺 / 組織リモデリング / マスト細胞 / インヒビンレセプター / 下垂本 / 卵胞 / FSH / 結合蛋白質 / 肝細胞 Less

アクチビンE抵抗性を検証するPrincipal Investigator
- Principal Investigator
  
  橋本統
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Nihon University
アクチビンE-KOマウスのNAFLD/NASHモデルとしての有用性Principal Investigator
- Principal Investigator
  
  橋本統
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Nihon University
Activin E-Knockout mice as a useful animal model of obesity/diabetesPrincipal Investigator
- Principal Investigator
  
  Hashimoto Osamu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Nagahama Institute of Bio-Science and Technology
  Kitasato University
A novel physiological function of mast cells on tissue remodeling
- Principal Investigator
  
  KAWAMINAMI Mitsumori
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Kitasato University
Development of a lung regeneration method with lung precursor cells
- Principal Investigator
  
  Kurisaki Akira
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical genome science
- Research Institution
  National Institute of Advanced Industrial Science and Technology
Effect of activin E on the prevention and therapy of metabolic syndrome.Principal Investigator
- Principal Investigator
  
  HASHIMOTO Osamu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Kitasato University
The role of activin E in metabolic syndrome and mood disorderPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Osamu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Kitasato University
Isolation of Inhibin Receptor and Siginal Transuduction In TGF-β Superfamily
- Principal Investigator
  
  HASEGAWA Yoshihisa
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  Kitasato University
インヒビンレセプターの同定とシグナル伝達に関する研究
- Principal Investigator
  
  HASEGAWA Yoshihisa
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Kitasato University
新規アクチビンβサブユニット遺伝子の機能解析Principal Investigator
- Principal Investigator
  
  橋本統
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Kitasato University
Effects of fetal and neonatal exposure of male mice to diethylstilbestrol as endocrine disrupter on the reproductive and neuroendocrine system
- Principal Investigator
  
  HOSHI Nobuhiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Kitasato University

All 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] Activins and Inhibins(Vitamins and Hormones, Vol.85)2011
- Author(s)
  Hashimoto O., Funaba M.
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-21580370
[Book] Activin in glucose metabolism2011
- Author(s)
  Hashimoto, O. and Funaba, M.
- Publisher
  Academic Press
- Data Source
  KAKENHI-PROJECT-21580370
[Journal Article] Identification and characterization of canine growth differentiation factor-9 and its splicing variant2012
- Author(s)
  Hashimoto, O. Takagi, R., Yanuma, F., Doi, S., Shindo, J., Endo, H., Hasegawa, Y. and Shimasaki, S.
- Journal Title
  
  Gene
  
  Volume: 499 Pages: 266-272
- Data Source
  KAKENHI-PROJECT-21580370
[Journal Article] Identification and characterization of canine growth differentiation factor-9 and its splicing variant2012
- Author(s)
  Hashimoto O.
- Journal Title
  
  Gene
  
  Volume: (In press) Issue: 2 Pages: 266-272
- DOI
  10.1016/j.gene.2012.03.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580370
[Journal Article] Molecular cloning and expression of canine prolactin gene2010
- Author(s)
  Hashimoto, O., Yonezawa, T., Sugiyama, Y., Kawaminami, M. and Hasegawa, Y.
- Journal Title
  
  Exp. Anim.
  
  Volume: 59 Pages: 643-646
- NAID
  130000419260
- Data Source
  KAKENHI-PROJECT-21580370
[Journal Article] Molecular cloning and expression of canine prolactin gene.2010
- Author(s)
  Hashimoto O, Yonezawa T, Sugiyama Y, Kawaminami M, Hasegawa Y.
- Journal Title
  
  Experimental Animals
  
  Volume: 59 Pages: 643-646
- NAID
  130000419260
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580370
[Journal Article] Impliction of activin E in glucose metabolism : Transcriptional regulation of the inhibin/activin βE subunit gene in the liver.2009
- Author(s)
  Hashimoto O., Sekiyama K., Matsuo T., Hasegawa Y.
- Journal Title
  
  Life Sciences 85
  
  Pages: 534-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580370
[Journal Article] Oocyte-specific over-expression of mouse BMP-15 leads to accelerated follicul ogenesis and an early onset of acyclicity in transgenic mice2009
- Author(s)
  McMahon HE, Hashimoto O, Mellon PL, Shimasaki S
- Journal Title
  
  Endocrinology 149
  
  Pages: 2807-2815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580347
[Journal Article] Abnormalities in Aggression and Anxiety in Transgenic Mice Overexpressing Activin E2009
- Author(s)
  Sekiyama K.Hashimoto O, Ushiro Y, Adachi C, Kikusui T, Tane mura K, Hasegawa Y.
- Journal Title
  
  Biochem Biophys Res Commun 385
  
  Pages: 319-323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580370
[Journal Article] Gene expression of the TGF-b family in rat brain infected with Borna disease virus.2009
- Author(s)
  Nishino Y, Ooishi R, Kurokawa S, Fujino K, Murakami M, Madarame H, Hashimoto O, Sugiyama K, Funaba M.
- Journal Title
  
  Microbes Infect 11
  
  Pages: 737-743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580370
[Journal Article] The role of activin E in glucose metabolism : Transcriptional regulation of the inhibin/activinss E subunit gene in the liver2009
- Author(s)
  Hashimoto, O., Sekiyama, K., Matsuo, T. and Hasegawa, Y.
- Journal Title
  
  Life Sci.
  
  Volume: 85 Pages: 534-540
- Data Source
  KAKENHI-PROJECT-21580370
[Journal Article] Oocyte-specific over-expression of mouse BMP-15 leads to accelerated folliculogenesis and an early onset of acyclicity intransgenic mice2008
- Author(s)
  McMahon H.E., Hashimoto O., Mellon P.L. Shimasaki S.
- Journal Title
  
  Endocrinology 149
  
  Pages: 2807-2815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580347
[Journal Article] Transgenic expression of a myostatin inhibitor derived from follistatin increases skeletal muscle mass and ameliorates dystrophic pathology in mdx mice2008
- Author(s)
  Nakatani M, Sugino H, Matsumoto M, Hashimoto O, Hasegawa Y, Murakami T, Uezumi A, Takeda S, Noji S, Sunada Y, Tsuchida K
- Journal Title
  
  The FASEB Journal 22
  
  Pages: 477-487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580347
[Journal Article] Characterization of follistatinrelated gene as a negative regulatory factor for activin family members during mouse heart development2007
- Author(s)
  Takehara-Kasamatsu Y, Tsuchida K, Nakatani M, Murakami T, Kurisaki A, Hashimoto O, Ohuchi H, Kurose H, Mori K, Kagami S, Noji S, Sugino H
- Journal Title
  
  J Med Invest 54(3-4)
  
  Pages: 276-288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580347
[Journal Article] Impaired growth of pancreatic exocrine cells in transgenic mice expressing human activin βE subunit.2006
- Author(s)
  Hashimoto O, Ushiro U, Sekiyama K, Yamaguchi O, Yoshioka K, Mutoh K, Hasegawa Y
- Journal Title
  
  Biochem Biophys Res Commun 341
  
  Pages: 416-424
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380195
[Journal Article] Impaired growth of pancreatic exocrine cells In transgenic mice expressing human activin bE subunit.2006
- Author(s)
  Hashimoto O, Ushiro U, Sekiyama K, Yamaguchi O, Yoshioka K, Mutoh K, Hasegawa Y
- Journal Title
  
  Biochem.Biophys.Res.Commun. (In press)
- Data Source
  KAKENHI-PROJECT-15380195
[Journal Article] Posttranslational processing of mouse and human BMP-15 : Ootential implication in the determination of ovulation quota.2005
- Author(s)
  Hashimoto O, Moore RK, Shimasaki S
- Journal Title
  
  Proc Natl Acad Sci USA 102
  
  Pages: 5426-5431
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380195
[Journal Article] Posttranslational processing of mouse and human BMP-15 : Potential implication in the determination of ovulation quota.2005
- Author(s)
  Hashimoto O, Moore RK, Shimasaki S
- Journal Title
  
  Proc Natl Acad Sci USA 102
  
  Pages: 5426-5431
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380195
[Journal Article] Post-translational processing of mouse and human BMP-15.2005
- Author(s)
  Hashimoto O, Moore PK, Shimazaki S
- Journal Title
  
  Proc Natl Acad Sci USA 102
  
  Pages: 5426-5431
- Data Source
  KAKENHI-PROJECT-15380195
[Journal Article] Activin isoforms signal through type I receptor serine/threonine kinase ALK7.2004
- Author(s)
  Tsuchida K, Nakatani M, Yamakawa N, Hashimoto O, Hasegawa Y, Sugino H
- Journal Title
  
  Ani Reprod Sci 82-83
  
  Pages: 183-194
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380195
[Journal Article] Activin isoforms signal through type I receptor serine/threonine kinase ALK7.2004
- Author(s)
  K.Tsuchida, M Nakatani, N.Yamakawa, O.Hashimoto, Y.Hasegawa, H.Sugino
- Journal Title
  
  Molecular Cellular Endocrinology 220
  
  Pages: 59-65
- Data Source
  KAKENHI-PROJECT-14656117
[Journal Article] Activin isoforms signal through type I receptor serine/threonine kinase ALK7.2004
- Author(s)
  K.Tsuchida, M.Nakatani, N.Yamakawa, 0.Hashimoto, Y.Hasegawa, H.Sugino
- Journal Title
  
  Molecular Cellular Endocrinology 220
  
  Pages: 59-65
- Data Source
  KAKENHI-PROJECT-15380195
[Journal Article] Activin isoforms signal through type Ireceptor serine/threonine kinase ALK7.2004
- Author(s)
  Tsuchida K, Nakatani M, Yamakawa N, Hashimoto O, Hasegawa Y, Sugino H
- Journal Title
  
  Mol Cell Endocrinol 220
  
  Pages: 59-65
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380195
[Journal Article] Gene expression of the TGF-b family in rat brain infected with Borna disease virus
- Author(s)
  Nishino Y., Ooishi R., Kurokawa S., Fujino K., Murakami M., Madarame H., Hashimoto O., Sugiyama K., Funaba M.
- Journal Title
  
  Microbes and Infection (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580347
[Journal Article] Abnormalities in Aggression and Anxiety in Transgenic Mice Overexpressing Activin E
- Author(s)
  Sekiyama K,. Hashimoto O., Ushiro Y., Adachi C., Kikusui T., Tanemura K., Hasegawa Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580347
[Presentation] TGF-bファミリーによる褐色脂肪前駆細胞の分化制御2011
- Author(s)
  吉田拓史, 橋本統, 河田照雄, 舟場正幸, 松井徹
- Organizer
  日本畜産学会第114回大会
- Place of Presentation
  十和田
- Year and Date
  2011-08-27
- Data Source
  KAKENHI-PROJECT-21580370
[Presentation] TGF-βファミリーによる褐色脂肪前駆細胞の分化制御2011
- Author(s)
  橋本統
- Organizer
  日本畜産学会第114回大会
- Place of Presentation
  北里大学獣医学部(青森県)
- Year and Date
  2011-08-27
- Data Source
  KAKENHI-PROJECT-23380175
[Presentation] Roles of the TGF-b family in brown adipocyte differentiation2011
- Author(s)
  Yoshida, T., Hashimoto, O., Kawada, T., Funaba, M. and Matsui, T.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-21580370
[Presentation] Abnormalities in aggression and Anxiety in transgenic mice overexpressing activin E2010
- Author(s)
  Sekiyama K, Hashimoto O, Hasegawa Y.
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(神戸)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-21580370
[Presentation] アクチビンEの糖代謝への関与:肝臓におけるアクチビンE遺伝子の発現調節2009
- Author(s)
  橋本統, 関山一成, 松尾剛, 長谷川喜久
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21580370
[Presentation] 肥満および高インスリン感受性を示すアクチビントランスジェニックマウスの解析2008
- Author(s)
  関山一成、橋本統、長谷川喜久
- Organizer
  第31 回日本分子生物学会年会/第81 回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19580347
[Presentation] 肥満および高インスリン感受性を示すアクチビントランスジェニックマウスの解析2008
- Author(s)
  関山一成, 橋本統, 長谷川喜久
- Organizer
  第31回日本分子生物学会年会/第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19580347
[Presentation] 肥満および高インスリン感受性を示すアクチビン遺伝子改変マウスの解析2008
- Author(s)
  橋本統、関山一成、長谷川喜久
- Organizer
  第22回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  品川
- Year and Date
  2008-02-08
- Data Source
  KAKENHI-PROJECT-19580347
[Presentation] 肥満および高インスリン感受性を示すアクチビン遺伝子改変マウスの解析2008
- Author(s)
  橋本統
- Organizer
  第22回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  昭和大学旗の台キャンパス(品川)
- Year and Date
  2008-02-09
- Data Source
  KAKENHI-PROJECT-19580347
[Presentation] 高インスリン感受性を示すアクチビン遺伝子改変マウスの解析2007
- Author(s)
  橋本統
- Organizer
  第30回日本分子生物学会年会/第80回日本生化学会大会合大会
- Place of Presentation
  パシフィコ横浜(桜木町)
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19580347
[Presentation] 高インスリン感受性を示すアクチビン遺伝子改変マウスの解析2007
- Author(s)
  橋本統、関山一成、宇城有紀、長谷川喜久
- Organizer
  第80回日本生化学会大会合同大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19580347

1. HASEGAWA Yoshihisa (40092001)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
2. HOSHI Nobuhiko (10209223)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KAWAMINAMI Mitsumori (00153007)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. YONEZAWA Tomohiro (10433715)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SUGAWARA Teruo (40250451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Kurisaki Akira (60346616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 吉川泰永 (00552043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 高田仁実 (80641068)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 中島由郎 (30455430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Hashimoto Osamu 橋本 統

橋本 統 ハシモト オサム

HASHIMOTO Osamu 橋本 統

Research Projects

Research Products

Co-Researchers

アクチビンE抵抗性を検証するPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アクチビンE-KOマウスのNAFLD/NASHモデルとしての有用性Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Activin E-Knockout mice as a useful animal model of obesity/diabetesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel physiological function of mast cells on tissue remodeling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a lung regeneration method with lung precursor cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of activin E on the prevention and therapy of metabolic syndrome.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of activin E in metabolic syndrome and mood disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Isolation of Inhibin Receptor and Siginal Transuduction In TGF-β Superfamily

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

インヒビンレセプターの同定とシグナル伝達に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規アクチビンβサブユニット遺伝子の機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of fetal and neonatal exposure of male mice to diethylstilbestrol as endocrine disrupter on the reproductive and neuroendocrine system

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] Activins and Inhibins(Vitamins and Hormones, Vol.85)2011

Author(s)

Publisher

Data Source

[Book] Activin in glucose metabolism2011

Author(s)

Publisher

Data Source

[Journal Article] Identification and characterization of canine growth differentiation factor-9 and its splicing variant2012

Hashimoto Osamu 橋本統

橋本統ハシモトオサム

HASHIMOTO Osamu 橋本統