Kubota Mie 窪田美恵 (坂下美恵)

… Alternative Names

坂下美恵

Kubota-Sakashita Mie 窪田美恵

KUBOTA Mie 窪田美恵

坂下美恵サカシタミエ

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Researcher Number	90344035
Affiliation (Current)	2025: 順天堂大学, 大学院医学研究科, 特任准教授
Affiliation (based on the past Project Information) *help	2024: 順天堂大学, 大学院医学研究科, 特任准教授 2021 – 2022: 順天堂大学, 大学院医学研究科, 特任准教授 2021: 順天堂大学, 医学(系)研究科(研究院), 特任准教授 2020: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 客員研究員 2018 – 2019: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 専門職研究員 … More 2017: 国立研究開発法人理化学研究所, 脳科学総合研究センター, 専門職研究員 2010 – 2011: 独立行政法人理化学研究所, 精神疾患動態研究チーム, 専門職研究員 2008 – 2009: The Institute of Physical and Chemical Research, 精神疾患動態研究チーム, 研究員 2007: The Institute of Physical and Chemical Research, 精神疾患動態研究チーム, 研究員 2003 – 2006: 独立行政法人理化学研究所, 精神疾患動態研究チーム, 研究員 Less
Review Section/Research Field	Principal Investigator Psychiatric science / Basic Section 52030:Psychiatry-related Except Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science
Keywords	Principal Investigator ミトコンドリア / mitochondria / 気分障害 / calcium signaling / polymerase γ / 視床室傍核 / polymeraseγ / cyclophilin D / cycrosporin A / permeability transition pore … More / 双極性障害 / G protein-coupled receptor / hippocampus / ミトコンドリア障害 / シナプス / ミトコンドリア透過性遷移 / C1qbp / モノアミン酸化酵素B / モノアミン / 酸化ストレス / 稀少アミン / フェニルエチルアミン / モノアミンオキシダーゼB / mtDNA / GFP / bipolar disorder / mitochondrial DNA / polymerase gamma / Mitochondria / 精神薬理学 / 電気生理学 / 小胞体 / 代謝型グルタミン酸受容体 / カルシウムシグナリング / patch clamp recording / calcium imaging / inositol 1,4,5-trisphosphate … More Except Principal Investigator 双極症 / WFS1 / バイオテクノロジー / ゲノム / 脳・神経 / 脳神経疾患 / 神経科学 / ミトコンドリアDNA / ミトコンドリア / 視床室傍核 / 双極性障害 Less

ヒト視床室傍核の遺伝子発現プロファイル解析に基づく形態学的機能分類Principal Investigator
- Principal Investigator
  
  窪田美恵 (坂下美恵)
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Juntendo University
The role of WFS1 in bipolar disorder
- Principal Investigator
  
  垣内千尋
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Juntendo University
気分安定薬標的候補分子としてのミトコンドリア蛋白C1qbpの生理的役割Principal Investigator
- Principal Investigator
  
  窪田美恵 (坂下美恵)
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Juntendo University
Significance of MAOB in paraventricular nucleus-specific mitochondrial defects that relevant to a cause of mood disordersPrincipal Investigator
- Principal Investigator
  
  Kubota-Sakashita Mie
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Institute of Physical and Chemical Research
Role of paraventricular thalamic nucleus in bipolar disorder
- Principal Investigator
  
  KATO TADAFUMI
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Juntendo University
  Institute of Physical and Chemical Research
Detection of mitochondrial DNA defects in GABAergic neurons of model mice for bipolar disorderPrincipal Investigator
- Principal Investigator
  
  KUBOTA Mie
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research
Effects of drug acting on mitochondrial calcium uptake in model mice for bipolar disorderPrincipal Investigator
- Principal Investigator
  
  KUBOTA Mie
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research
双極性障害におけるカルシウムシグナリング障害の遺伝子改変動物を用いた検討Principal Investigator
- Principal Investigator
  
  窪田美恵
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research
双極性障害モデル動物確立のための遺伝子改変動物における行動学的・生理学的検討Principal Investigator
- Principal Investigator
  
  窪田美恵
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  The Institute of Physical and Chemical Research

All 2022 2021 2020 2019 2018 2017 2011 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus2022
- Author(s)
  Obata Youhei、Kubota-Sakashita Mie、Kasahara Takaoki、Mizuno Masafumi、Nemoto Takahiro、Kato Tadafumi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 17-17
- DOI
  10.1038/s41598-021-03885-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01573
[Journal Article] Cell-type-specific DNA methylation analysis of the frontal cortices of mutant Polg1 transgenic mice with neuronal accumulation of deleted mitochondrial DNA2021
- Author(s)
  Sugawara H, Bundo M, Kasahara T, Nakachi Y, Ueda J, Kubota-Sakashita M, Iwamoto K, Kato T
- Journal Title
  
  Molecular Brain
  
  Volume: 15 Issue: 1 Pages: 9-9
- DOI
  10.1186/s13041-021-00894-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07567, KAKENHI-PROJECT-18K15486, KAKENHI-PLANNED-18H05430, KAKENHI-PROJECT-17H01573, KAKENHI-PROJECT-18H02753, KAKENHI-PROJECT-21K07548, KAKENHI-PROJECT-22K07580, KAKENHI-PLANNED-18H05435
[Journal Article] Unbiased PCR-free spatio-temporal mapping of the mtDNA mutation spectrum reveals brain region-specific responses to replication instability2020
- Author(s)
  Bagge Emilie Kristine、Fujimori-Tonou Noriko、Kubota-Sakashita Mie、Kasahara Takaoki、Kato Tadafumi
- Journal Title
  
  BMC Biology
  
  Volume: 18 Issue: 1 Pages: 150-150
- DOI
  10.1186/s12915-020-00890-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05435, KAKENHI-PROJECT-17H01573
[Journal Article] Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder2018
- Author(s)
  Kato TM, Kubota-Sakashita M, Fujimori-Tonou N, Saitow F, Fuke S, Masuda A, Itohara S, Suzuki H, Kato T.
- Journal Title
  
  Molecular Psychiatry
  
  Volume: 23 Issue: 10 Pages: 2039-2049
- DOI
  10.1038/s41380-018-0074-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01573
[Journal Article] Abnormal Ca^<2+> dynamics in transgenic mice with neuron-specific mitochondrial DNA defects.2006
- Author(s)
  Kubota, M., Kasahara, T., Nakamura, T., Ishiwata, M., Miyauchi, T., Kato, T.
- Journal Title
  
  Journal of Neuroscience 26(47)
  
  Pages: 12314-12324
- Data Source
  KAKENHI-PROJECT-17790831
[Presentation] Identification of the substrates of MAO-B in mouse brain tissues by measuring the monoamines and metabolites using a high sensitive LC-MS/MS method2020
- Author(s)
  Youhei Obata, Mie Kubota-Sakashita, Takaoki Kasahara, Masafumi Mizuno and Tadafumi Kato
- Organizer
  日本神経科学会
- Data Source
  KAKENHI-PROJECT-18K07615
[Presentation] Neural dysfunction in paraventricular thalamus impacted by MAO-B in bipolar disorder and depression2019
- Author(s)
  Youhei Obata, Mie Kubota-Sakashita, Takaoki Kasahara, Masafumi Mizuno and Tadafumi Kato
- Organizer
  日本精神神経学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07615
[Presentation] mmunohistochemical analyses of paraventricular thalamic nucleus (PVT) in human postmortem brains.2017
- Author(s)
  1.Kubota-Sakashita M, Mechawar N, Shimogori T, Turecki G, Kato T
- Organizer
  Society for Neuroscience (SfN)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01573
[Presentation] Histochemical detection of neurons accumulating mitochondrial DNA deletions in mice with mutant Polg1 gene2011
- Author(s)
  Mie Kubota-Sakashita
- Organizer
  8^<th> World Congress of Neuroscience(International Brain Research Organization)
- Place of Presentation
  Italy(Florence)
- Year and Date
  2011-05-22
- Data Source
  KAKENHI-PROJECT-21791157
[Presentation] Histochemical detection of neurons accumulating mitochondria 1 DNA deletions in mice with mutant Polg1 gene2011
- Author(s)
  Mie Kubota-Sakashita
- Organizer
  8^<th> World Congress of Neuroscience (International Brain Research Organization)
- Place of Presentation
  Italy (Florence)
- Year and Date
  2011-05-22
- Data Source
  KAKENHI-PROJECT-21791157
[Presentation] 変異Polg1が脳内に発現するマウスにおけるミトコンドリアDNA欠失蓄積細胞の組織学的検討2011
- Author(s)
  窪田-坂下美恵
- Organizer
  第33回日本生物学的精神医学会
- Place of Presentation
  東京都(港区台場)
- Year and Date
  2011-07-15
- Data Source
  KAKENHI-PROJECT-21791157
[Presentation] 異常なミトコンドリアDNAが脳内に蓄積するマウスにおけるドーパミン神経系障害に関する検討2009
- Author(s)
  窪田美恵
- Organizer
  日本生物学的精神医学会
- Place of Presentation
  京都市・国立京都国際会館
- Year and Date
  2009-04-24
- Data Source
  KAKENHI-PROJECT-21791157
[Presentation] Abnormal mitochondrial Ca^<2+> dynamics and behavioral phenotypes in transgenic mice with mitochondrial DNA defects2008
- Author(s)
  Mie Kubota
- Organizer
  The 7th European Meeting on Mitochondrial Pathology
- Place of Presentation
  the City Conference Centre Stockholm
- Year and Date
  2008-07-12
- Data Source
  KAKENHI-PROJECT-19790844
[Presentation] Effects of drug acting on mitochondrial calcium uptak in mutant POLG transgenic mice2008
- Author(s)
  Mie Kubota
- Organizer
  2nd World Federation of Societies of Biological Psychiatry Asia-Paific Congress and 30th Annual Meeting of Japan Societies Biological Psychiatry
- Place of Presentation
  Toyama
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-19790844
[Presentation] Abnormal mitochondrial Ca2+ dynamics and behavioral phenotypes in transgenic mice with mitochondrial DNA defects2008
- Author(s)
  Mie Kubota
- Organizer
  The 7th EuropeanMeeting on Mitochondria Pathology
- Place of Presentation
  Stockholm
- Year and Date
  2008-06-12
- Data Source
  KAKENHI-PROJECT-19790844
[Presentation] Effects of drug acting on mitochondrial calcium uptake in mutant POLG transgenic mice2008
- Author(s)
  窪田美恵
- Organizer
  日本生物学的精神医学会
- Place of Presentation
  ANAクラウンプラザホテル富山
- Year and Date
  2008-09-12
- Data Source
  KAKENHI-PROJECT-19790844
[Presentation] GENE EXPRESSION PROFILE IN THE BRAIN OF ANIMAL MODELFOR BIPOLAR DISOEDER2007
- Author(s)
  Mie Kubota
- Organizer
  Cold Spring Harbor Meeting (Integrative Approaches To Brain Complexity)
- Place of Presentation
  The Welcome Trust Conference Center
- Year and Date
  2007-09-27
- Data Source
  KAKENHI-PROJECT-19790844
[Presentation] Gene Expression Profile in the Brain of Animal Model for Bipolar Disorder2007
- Author(s)
  Mie Kubota
- Organizer
  Cold Spring Harbor Laboratory Meeting Integrative Approaches to Brain Complexity
- Place of Presentation
  Cambridge
- Year and Date
  2007-09-27
- Data Source
  KAKENHI-PROJECT-19790844
[Presentation] 双極性障害モデル動物における単離ミトコンドリアを用いたカルシウム取り込み脳の薬理学的検討2007
- Author(s)
  窪田美恵
- Organizer
  日本生物精神医学会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2007-07-13
- Data Source
  KAKENHI-PROJECT-19790844

1. 島康之 (60815885)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KATO TADAFUMI (30214381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. 笠原和起 (50344031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 垣内千尋 (90342766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 文東美紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kubota Mie 窪田 美恵 (坂下 美恵)

坂下美恵

Kubota-Sakashita Mie 窪田 美恵

KUBOTA Mie 窪田 美恵

坂下 美恵 サカシタ ミエ

Research Projects

Research Products

Co-Researchers

ヒト視床室傍核の遺伝子発現プロファイル解析に基づく形態学的機能分類Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of WFS1 in bipolar disorder

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

気分安定薬標的候補分子としてのミトコンドリア蛋白C1qbpの生理的役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of MAOB in paraventricular nucleus-specific mitochondrial defects that relevant to a cause of mood disordersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of paraventricular thalamic nucleus in bipolar disorder

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Detection of mitochondrial DNA defects in GABAergic neurons of model mice for bipolar disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of drug acting on mitochondrial calcium uptake in model mice for bipolar disorderPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

双極性障害におけるカルシウムシグナリング障害の遺伝子改変動物を用いた検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

双極性障害モデル動物確立のための遺伝子改変動物における行動学的・生理学的検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell-type-specific DNA methylation analysis of the frontal cortices of mutant Polg1 transgenic mice with neuronal accumulation of deleted mitochondrial DNA2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Unbiased PCR-free spatio-temporal mapping of the mtDNA mutation spectrum reveals brain region-specific responses to replication instability2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder2018

Author(s)

Journal Title

Kubota Mie 窪田美恵 (坂下美恵)

Kubota-Sakashita Mie 窪田美恵

KUBOTA Mie 窪田美恵

坂下美恵サカシタミエ