IKEHARA Tsuyoshi 池原強

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Ikehara Tsuyoshi 池原強

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Researcher Number	90359951
Other IDs
Affiliation (Current)	2025: 国立研究開発法人水産研究・教育機構, 水産大学校, 教授
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人水産研究・教育機構, 水産大学校, 教授 2020 – 2022: 国立研究開発法人水産研究・教育機構, 水産大学校, 教授 2016 – 2017: 国立研究開発法人水産研究・教育機構, 水産大学校, 教授 2015: 独立行政法人水産大学校, その他部局等, 准教授 2003 – 2004: 長崎大学, 大学院・医歯薬学総合研究科, 講師
Review Section/Research Field	Principal Investigator Basic Section 40040:Aquatic life science-related / Aquatic life science Except Principal Investigator General medical chemistry
Keywords	Principal Investigator シガトキシン / 海洋自然毒 / 代謝 / 阻害機構 / ナトリウムチャネル / ブレべトキシン / リコンビナントタンパク / 電位依存性Na⁺チャネル / 電位依存性Na+チャネル / 酸化酵素 / シガテラ … More Except Principal Investigator … More transcription / chromatin / nucleosome / phosphorylation / acetylation / histone / 遺伝子転写 / クロマチン / ヌクレオソーム / リン酸化 / アセチル化 / ヒストン Less

Elucidation of the metabolic mechanism of ciguatoxins (CTXs) in fishPrincipal Investigator
- Principal Investigator
  
  池原強
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 40040:Aquatic life science-related
- Research Institution
  Fisheries Research and Education Agency
Molecular mechanism of voltage-gated Na+ channel inhibition by ciguatoxin analogs (CTXs)Principal Investigator
- Principal Investigator
  
  Ikehara Tsuyoshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 40040:Aquatic life science-related
- Research Institution
  Fisheries Research and Education Agency
Verification of biooxidation of ciguatoxins leading to species specific toxin profilesPrincipal Investigator
- Principal Investigator
  
  Ikehara Tsuyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Aquatic life science
- Research Institution
  Fisheries Research and Education Agency
  National Fisheries University
Core histone modifications change the higher order of DNA structurec resulting in its biological output
- Principal Investigator
  
  ITO Takashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Nagasaki University

All 2023 2022 2021 2018 2017 2016 2015 2004 2003

All Journal Article Presentation Book

[Book] 新ラボマニュアル遺伝子工学2003
- Author(s)
  分担執筆池原強, 中川武弥, 伊藤敬
- Total Pages
  291
- Publisher
  丸善株式会社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390098
[Journal Article] Analytical Studies on Ciguateric Fish in Okinawa, Japan (II): The Grouper Variola albimarginata2023
- Author(s)
  Oshiro Naomasa、Nagasawa Hiroya、Nishimura Mio、Kuniyoshi Kyoko、Kobayashi Naoki、Sugita-Konishi Yoshiko、Ikehara Tsuyoshi、Tachihara Katsunori、Yasumoto Takeshi
- Journal Title
  
  Journal of Marine Science and Engineering
  
  Volume: 11 Issue: 2 Pages: 242-242
- DOI
  10.3390/jmse11020242
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06246
[Journal Article] Analysis of Ciguatoxins in the Spotted Knifejaw, <i>Oplegnathus punctatus</i> from the Waters of Japan2022
- Author(s)
  Tomikawa Takumi、Kuniyoshi Kyoko、Ito Shiori、Sakugawa Satsuki、Ishikawa Akira、Saito Toshio、Kojima Takashi、Asakura Hiroshi、Ikehara Tsuyoshi、Oshiro Naomasa
- Journal Title
  
  Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)
  
  Volume: 63 Issue: 5 Pages: 190-194
- DOI
  10.3358/shokueishi.63.190
- ISSN
  0015-6426, 1882-1006
- Year and Date
  2022-10-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06246
[Journal Article] Specification of the Okadaic Acid Equivalent for Okadaic Acid, Dinophysistoxin-1, and Dinophysistoxin-2 Based on Protein Phosphatase 2A Inhibition and Cytotoxicity Assays Using Neuro 2A Cell Line2021
- Author(s)
  Ikehara Tsuyoshi、Chikanishi Kazuya、Oshiro Naomasa
- Journal Title
  
  Journal of Marine Science and Engineering
  
  Volume: 9 Issue: 10 Pages: 1140-1140
- DOI
  10.3390/jmse9101140
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06246
[Journal Article] Long noncoding RNAs transcribed downstream of the human β-globin locus regulate β-globin gene expression2021
- Author(s)
  Higashi Miki、Ikehara Tsuyoshi、Nakagawa Takeya、Yoneda Mitsuhiro、Hattori Naoko、Ikeda Masaaki、Ito Takashi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 171 Issue: 3 Pages: 287-294
- DOI
  10.1093/jb/mvab130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06246, KAKENHI-PROJECT-20K06489
[Journal Article] タンパク質脱リン酸化酵素2A（PP2A）を利用した下痢性貝毒簡易検査法の評価2017
- Author(s)
  池原強,木下翼,黒川純花,中島志穂子,前川公彦,大城直雅,安元健
- Journal Title
  
  日本水産学会誌
  
  Volume: 83 Pages: 367-372
- NAID
  130007331243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07594
[Journal Article] Biooxidation of Ciguatoxins Leads to Species-Specific Toxin Profiles2017
- Author(s)
  Ikehara Tsuyoshi、Kuniyoshi Kyoko、Oshiro Naomasa、Yasumoto Takeshi
- Journal Title
  
  Toxins
  
  Volume: 9 Issue: 7 Pages: 205-205
- DOI
  10.3390/toxins9070205
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07594
[Journal Article] Efficient production of recombinant PP2A at a low temperature using a baculovirus expression system.2016
- Author(s)
  Tsuyoshi Ikehara，Shihoko Nakashima，Junichi Nakashima，Tsubasa Kinoshita，Takeshi Yasumoto
- Journal Title
  
  Biotechnology Reports
  
  Volume: Vol.11 Pages: 86-89
- DOI
  10.1016/j.btre.2016.07.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K07594
[Journal Article] Different responses of primary normal human hepatocytes and human hepatoma cells toward cyanobacterial hepatotoxin microcystin-LR2015
- Author(s)
  Tsuyoshi Ikehara, Junichi Nakashima, Shihoko Nakashima, Takeshi Yasumoto
- Journal Title
  
  Toxicon
  
  Volume: 105 Pages: 4-9
- DOI
  10.1016/j.toxicon.2015.08.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07594
[Journal Article] 下痢性貝毒の簡易検査法の開発‐国際基準の導入へ向けた取り組み‐2015
- Author(s)
  池原　強
- Journal Title
  
  海洋水産エンジニアリング
  
  Volume: 122 Pages: 117-121
- NAID
  40020536314
- Data Source
  KAKENHI-PROJECT-15K07594
[Journal Article] Enhancer of Acetyltransferase Chameau(EAChm) Is a Novel Transcriptional Co-Activator2015
- Author(s)
  Takeya Nakagawa, Tsuyoshi Ikehara, Masamichi Doiguchi, Yuko Imamura, Miki Higashi, Mitsuhiro Yoneda, Takashi Ito
- Journal Title
  
  PLoS ONE
  
  Volume: 10(11) Issue: 11 Pages: e0142305-e0142305
- DOI
  10.1371/journal.pone.0142305
- NAID
  120006987224
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07594, KAKENHI-ORGANIZER-24118001, KAKENHI-PLANNED-24118003
[Journal Article] Isfolavones stimulate estrogen receptor-mediated core histone acetylation2004
- Author(s)
  Hong, T., Nakagawa, T., Pan, W., Kim, M.Y., Kraus, W.L., Ikehara, T., Yasui, K., Aihara, H., Takebe, M., Muramatsu, M., Ito, T.
- Journal Title
  
  Biochem Biophys Res Commun 317
  
  Pages: 259-264
- Data Source
  KAKENHI-PROJECT-15390098
[Journal Article] Isoflavones stimulate estrogen receptor-mediated core histone acetylation.2004
- Author(s)
  Hong, T., Nakagawa, T., Pan, W., Kim, M.Y., Kraus, W.L, Ikehara, T., Yasui, K., Aihara, H., Takebe, M., Muramatsu, M., Ito, T.
- Journal Title
  
  Biochem Biophys Res Commun 317
  
  Pages: 259-264
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390098
[Presentation] 酸化酵素によるシガトキシンの化学構造修飾2018
- Author(s)
  池原強
- Organizer
  シガトキシン関連資料展示記念ワークショップ
- Data Source
  KAKENHI-PROJECT-15K07594
[Presentation] Verification of biooxidation products of ciguatoxins leading to species specific toxin profiles2016
- Author(s)
  Tsuyossi Ikehara
- Organizer
  First Workshop on Emerging Toxins
- Place of Presentation
  Spain
- Year and Date
  2016-09-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07594
[Presentation] ホタテガイ（Patinopecten yessoensis）可食部試料を用いたPP2A活性阻害法による下痢性貝毒簡易分析法の評価2016
- Author(s)
  木下翼，池原強，前川公彦，中島志穂子，大城直雅，安元健
- Organizer
  平成28年度日本水産学会秋季大会
- Place of Presentation
  近畿大学農学部奈良キャンパス
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PROJECT-15K07594
[Presentation] 酸化酵素によるシガトキシンの化学構造修飾2016
- Author(s)
  池原強，大城直雅，國吉杏子，安元健
- Organizer
  第30 回海洋生物活性談話会
- Place of Presentation
  鳥取大学
- Year and Date
  2016-05-14
- Data Source
  KAKENHI-PROJECT-15K07594
[Presentation] シガテラ魚CTX酸化酵素の検出2015
- Author(s)
  池原強，大城直雅，安元健
- Organizer
  第29回海洋生物活性談話会
- Place of Presentation
  静岡県
- Year and Date
  2015-05-09
- Data Source
  KAKENHI-PROJECT-15K07594
[Presentation] ヒト正常肝細胞(h-Nheps) およびヒト肝がん由来細胞（HepG2）に対するミクロシスチン-LRの毒性評価2015
- Author(s)
  池原強，中島淳一，中島志穂子，安元健
- Organizer
  第38回日本分子生物学会年会，第88回日本生化学会大会合同大会
- Place of Presentation
  兵庫県
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K07594

1. OSHIRO Naomasa (20507032)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. ITO Takashi (90306275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. NAKAGAWA Takeya (50363502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. YASUI Kiyoshi (50372777)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. YASUMOTO Takeshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results

IKEHARA Tsuyoshi 池原 強

Ikehara Tsuyoshi 池原 強

Research Projects

Research Products

Co-Researchers

Elucidation of the metabolic mechanism of ciguatoxins (CTXs) in fishPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of voltage-gated Na+ channel inhibition by ciguatoxin analogs (CTXs)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Verification of biooxidation of ciguatoxins leading to species specific toxin profilesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Core histone modifications change the higher order of DNA structurec resulting in its biological output

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 新ラボマニュアル遺伝子工学2003

Author(s)

Total Pages

Publisher

Description

Data Source

[Journal Article] Analytical Studies on Ciguateric Fish in Okinawa, Japan (II): The Grouper Variola albimarginata2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of Ciguatoxins in the Spotted Knifejaw, <i>Oplegnathus punctatus</i> from the Waters of Japan2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Specification of the Okadaic Acid Equivalent for Okadaic Acid, Dinophysistoxin-1, and Dinophysistoxin-2 Based on Protein Phosphatase 2A Inhibition and Cytotoxicity Assays Using Neuro 2A Cell Line2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long noncoding RNAs transcribed downstream of the human β-globin locus regulate β-globin gene expression2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] タンパク質脱リン酸化酵素2A（PP2A）を利用した下痢性貝毒簡易検査法の評価2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Biooxidation of Ciguatoxins Leads to Species-Specific Toxin Profiles2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient production of recombinant PP2A at a low temperature using a baculovirus expression system.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Different responses of primary normal human hepatocytes and human hepatoma cells toward cyanobacterial hepatotoxin microcystin-LR2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 下痢性貝毒の簡易検査法の開発‐国際基準の導入へ向けた取り組み‐2015

Author(s)

IKEHARA Tsuyoshi 池原強

Ikehara Tsuyoshi 池原強