UNO Yasuhiro 宇野泰広

… Alternative Names

Uno Yasuhiro 宇野泰広

宇野泰広ウノヤスヒロ

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Researcher Number	90372276
Other IDs	https://orcid.org/0000-0001-9040-1681
Affiliation (Current)	2025: 鹿児島大学, 農水産獣医学域獣医学系, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 鹿児島大学, 農水産獣医学域獣医学系, 准教授 2005: 北海道大学, 大学院・薬学研究科, 寄附講座教員 2005: 北海道大学, 大学院薬学研究科, 寄附講座教員
Review Section/Research Field	Principal Investigator Basic Section 42020:Veterinary medical science-related Except Principal Investigator Environmental pharmacy / Medical pharmacy
Keywords	Principal Investigator ゲノム / 獣医動物種 / 遺伝子多型 / 薬物代謝 / 次世代シーケンサー / 遺伝子 / 薬物代謝酵素 Except Principal Investigator P450 / 遺伝子多型 / CYP3A … More / Pronofol / Voriconazole / Thalidomide / Metabolic activation / CYP2B6 / Toxicity / 奇形 / 胎仔全培養 / ヒト型モデル動物 / CYP3A7 / ヒト型モデル / Tgマウス / サリドマイド / 代謝的活性化 / CYP3A5 / 胎児毒性 / 体臭 / 薬物相互作用 / トリメチルアミン / 個人差 / FMO3 Less

獣医学での薬物代謝の研究基盤構築を目指した薬物代謝酵素の遺伝子多型の網羅的解析Principal Investigator
- Principal Investigator
  
  宇野泰広
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Kagoshima University
Systematic identification and characterization of essential drug-metabolizing enzyme toward establishment of platform for drug metabolism research in veterinary speciesPrincipal Investigator
- Principal Investigator
  
  Uno Yasuhiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Kagoshima University
薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらす薬物相互作用と疾病の個人差
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Showa Pharmaceutical University
Molecular mechanism of chemical-induced toxicity in fetal livers
- Principal Investigator
  
  YAMAZAKI Hiroshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Showa Pharmaceutical University

All 2024 2023 2022 2021 2007

All Journal Article Presentation

[Journal Article] Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole2024
- Author(s)
  Uno Yasuhiro、Murayama Norie、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 52 Issue: 3 Pages: 266-273
- DOI
  10.1124/dmd.123.001583
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05538
[Journal Article] Molecular and functional characterization of flavin-containing monooxygenases (FMO1?6) in tree shrews2024
- Author(s)
  Uno Yasuhiro、Makiguchi Miaki、Ushirozako Genki、Tsukiyama-Kohara Kyoko、Shimizu Makiko、Yamazaki Hiroshi
- Journal Title
  
  Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
  
  Volume: 277 Pages: 109835-109835
- DOI
  10.1016/j.cbpc.2024.109835
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05538
[Journal Article] Identification of cytochrome P450 2C18 and 2C76 in tree shrews: P450 2C18 effectively oxidizes typical human P450 2C9/2C19 chiral substrates warfarin and omeprazole with less stereoselectivity2024
- Author(s)
  Uno Yasuhiro、Minami Yuhki、Tsukiyama-Kohara Kyoko、Murayama Norie、Yamazaki Hiroshi
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: in press Pages: 115990-115990
- DOI
  10.1016/j.bcp.2023.115990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05538
[Journal Article] Transcript abundance of hepatic drug-metabolizing enzymes in two dog breeds compared with 14 species including humans2024
- Author(s)
  Uno Yasuhiro、Yamato Osamu、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 55 Pages: 101002-101002
- DOI
  10.1016/j.dmpk.2024.101002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05538
[Journal Article] Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan2024
- Author(s)
  Ushirozako Genki、Murayama Norie、Tsukiyama-Kohara Kyoko、Yamazaki Hiroshi、Uno Yasuhiro
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 52 Issue: 4 Pages: 305-311
- DOI
  10.1124/dmd.123.001603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05538
[Journal Article] A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models2024
- Author(s)
  Uno Yasuhiro、Shimizu Makiko、Yamazaki Hiroshi
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: in press Pages: 116124-116124
- DOI
  10.1016/j.bcp.2024.116124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K05538
[Journal Article] Novel cytochrome P450 2C94 (CYP2C94) functionally metabolizes diclofenac and omeprazole in dogs2023
- Author(s)
  Uno Yasuhiro、Morikuni Saho、Shiraishi Mitsuya、Asano Atsushi、Murayama Norie、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: - Issue: 5 Pages: 637-644
- DOI
  10.1124/dmd.122.001236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] Newly identified cytochrome P450 3A genes of tree shrews and pigs are expressed and encode functional enzymes2023
- Author(s)
  Uno Yasuhiro、Jikuya Shiori、Noda Yutaro、Oguchi Asuka、Murayama Norie、Kawaguchi Hiroaki、Tsukiyama-Kohara Kyoko、Yamazaki Hiroshi
- Journal Title
  
  Comparative Biochemistry and Physiology Part C
  
  Volume: 267 Pages: 109579-109579
- DOI
  10.1016/j.cbpc.2023.109579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20H03164
[Journal Article] Newly Identified Tree Shrew Cytochrome P450 2A13 (CYP2A13) is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog CYP2A13 and Pig CYP2A192023
- Author(s)
  Ushirozako Genki、Noda Yutaro、Murayama Norie、Kawaguchi Hiroaki、Tsukiyama-Kohara Kyoko、Yamazaki Hiroshi、Uno Yasuhiro
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: - Issue: 5 Pages: 610-617
- DOI
  10.1124/dmd.122.001152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20H03164
[Journal Article] Novel cytochrome P450 1 (CYP1) genes in tree shrews are expressed and encode functional drug-metabolizing enzymes2023
- Author(s)
  Uno Yasuhiro、Noda Yutaro、Murayama Norie、Tsukiyama-Kohara Kyoko、Yamazaki Hiroshi
- Journal Title
  
  Comparative Biochemistry and Physiology Part C
  
  Volume: 265 Pages: 109534-109534
- DOI
  10.1016/j.cbpc.2022.109534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20H03164
[Journal Article] Cloning and tissue expression of ATP-binding cassette transporters in cynomolgus macaques2022
- Author(s)
  Uno Yasuhiro、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 42 Pages: 100431-100431
- DOI
  10.1016/j.dmpk.2021.100431
- NAID
  210000173067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes2022
- Author(s)
  Uno Yasuhiro、Murayama Norie、Ijiri Moe、Kawaguchi Hiroaki、Yamato Osamu、Shiraishi Mitsuya、Asano Atsushi、Teraoka Hiroki、Mizukawa Hazuki、Nakayama Shouta M.M.、Ikenaka Yoshinori、Ishizuka Mayumi、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 50 Issue: 11 Pages: 1434-1441
- DOI
  10.1124/dmd.122.000930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20K07139
[Journal Article] Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes2022
- Author(s)
  Uno Yasuhiro、Ushirozako Genki、Uehara Shotaro、Murayama Norie、Fujiki Yuki、Kawaguchi Hiroaki、Tsukiyama-Kohara Kyoko、Yamazaki Hiroshi
- Journal Title
  
  Xenobiotica
  
  Volume: 52 Issue: 7 Pages: 687-696
- DOI
  10.1080/00498254.2022.2141153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20H03164
[Journal Article] Polymorphic cytochromes P450 in non-human primates2022
- Author(s)
  Uno Yasuhiro、Uehara Shotaro、Yamazaki Hiroshi
- Journal Title
  
  Advances in Pharmacology
  
  Volume: 95 Pages: 329-364
- DOI
  10.1016/bs.apha.2022.05.005
- ISBN
  9780323911092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] Drug-oxidizing and conjugating non-cytochrome P450 (non-P450) enzymes in cynomolgus monkeys and common marmosets as preclinical models for humans2022
- Author(s)
  Uno Yasuhiro、Uehara Shotaro、Yamazaki Hiroshi
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 197 Pages: 114887-114887
- DOI
  10.1016/j.bcp.2021.114887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20K07164
[Journal Article] Systematic identification and characterization of cynomolgus macaque solute carrier transporters2022
- Author(s)
  Uno Yasuhiro、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 43 Pages: 100437-100437
- DOI
  10.1016/j.dmpk.2021.100437
- NAID
  210000172987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] Molecular and Functional Characterization of N-Acetyltransferases in Common Marmosets and Pigs2022
- Author(s)
  Uno Yasuhiro、Uehara Shotaro、Ijiri Moe、Kawaguchi Hiroaki、Asano Atsushi、Shiraishi Mitsuya、Banju Kaito、Murayama Norie、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 50 Issue: 11 Pages: 1429-1433
- DOI
  10.1124/dmd.122.000919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] A Comprehensive Investigation of Dog Cytochrome P450 3A (CYP3A) Reveals a Functional Role of Newly Identified CYP3A98 in Small Intestine2022
- Author(s)
  Uno Yasuhiro、Jikuya Shiori、Noda Yutaro、Murayama Norie、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 51 Issue: 1 Pages: 38-45
- DOI
  10.1124/dmd.121.000749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] Differences in Hydrolase Activities in the Liver and Small Intestine between Marmosets and Humans2021
- Author(s)
  Honda Shiori、Fukami Tatsuki、Hirosawa Keiya、Tsujiguchi Takuya、Zhang Yongjie、Nakano Masataka、Uehara Shotaro、Uno Yasuhiro、Yamazaki Hiroshi、Nakajima Miki
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 49 Issue: 9 Pages: 718-728
- DOI
  10.1124/dmd.121.000513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434
[Journal Article] Cloning, sequence analysis, and tissue expression of marmoset paraoxonase 12021
- Author(s)
  Uehara Shotaro、Uno Yasuhiro、Shimizu Makiko、Yamazaki Hiroshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 39 Pages: 100398-100398
- DOI
  10.1016/j.dmpk.2021.100398
- NAID
  210000169422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20K06463
[Journal Article] Genetic variants of aldehyde oxidase (AOX) 1 in cynomolgus and rhesus macaques2021
- Author(s)
  Uno Yasuhiro、Uehara Shotaro、Murayama Norie、Yamazaki Hiroshi
- Journal Title
  
  Xenobiotica
  
  Volume: 51 Issue: 4 Pages: 494-499
- DOI
  10.1080/00498254.2021.1874564
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06434, KAKENHI-PROJECT-20K07139
[Presentation] Identification and characterization of tree shrew CYP2Cs2023
- Author(s)
  Yasuhiro Uno, Yuhki Minami, Genki Ushirozako, Kyoko Kohara, Norie Murayama, and Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K05538
[Presentation] イヌ、ブタ、ツパイおよびヒトチトクロムP450 2B分子種の薬物酸化酵素活性2023
- Author(s)
  村山典恵、藤木有樹、後迫玄城、野田優太朗、上原正太郎、宇野泰広、山崎浩史
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] イヌ、ブタ、カニクイザルにおけるチトクロムP450の同定・解析2023
- Author(s)
  宇野泰広，山崎浩史
- Organizer
  第50回日本毒性学会学術年会（シンポジウム）
- Invited
- Data Source
  KAKENHI-PROJECT-23K05538
[Presentation] Identification and characterization of tree shrew CYP2Ds2023
- Author(s)
  Genki Ushirozako, Norie Murayama, Kyoko Kohara, Hiroshi Yamazaki, and Yasuhiro Uno
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K05538
[Presentation] Cytochrome P450 2C21 and 2C41 functionally metabolize warfarin and omeprazole in dogs2023
- Author(s)
  Norie Murayama, Saho Morikuni, Yasuhiro Uno, and Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Invited
- Data Source
  KAKENHI-PROJECT-23K05538
[Presentation] イヌ肝チトクロムP450 3A酵素が触媒する典型的なヒト選択的基質に対する酸化酵素活性の個体差2023
- Author(s)
  野田優太朗、村山典恵、森國紗帆、宇野泰広、山崎浩史
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] イヌ肝と小腸に発現するチトクロムP450 3A分子種の同定とそれらの機能解析2022
- Author(s)
  村山典恵、野田優太朗、軸屋志織、宇野泰広、山崎浩史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] ツパイCYP2A13の同定と解析2022
- Author(s)
  後迫玄城、村山典恵、小原恭子、山崎浩史、宇野泰広
- Organizer
  第165回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] Characterization of tree shrew CYP2A13 in comparison with human, dog and pig CYP2As2022
- Author(s)
  Yasuhiro Uno, Genki Ushirozako, Yutaro Noda, Kyoko Kohara, Norie Murayama, and Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第37年会
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] Systematic identification and characterization of flavin-containing monooxygenases in cats, dogs, and pigs2021
- Author(s)
  Yasuhiro Uno, Makiko Shimizu, and Hiroshi Yamazaki
- Organizer
  日本薬物動態学会第36年会
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] カニクイザルにおける薬物代謝酵素の同定・解析2021
- Author(s)
  宇野泰広，山崎浩史
- Organizer
  第48回日本毒性学会学術年会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K06434
[Presentation] 日本人におけるCYP2C19^*17の頻度とCYP2C19代謝活性に及ぼす影響2007
- Author(s)
  杉本勝良, 宇野司, 山崎浩史, 立石智則
- Organizer
  第28回日本臨床薬理学会年会
- Place of Presentation
  栃木
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390034

1. YAMAZAKI Hiroshi (30191274)

# of Collaborated Projects: 4 results

# of Collaborated Products: 33 results
2. SHIMIZU Makiko (90307075)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MURAYAMA Norie (90219949)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 岩野俊介 (80374560)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 鎌滝哲也 (00009177)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 青山隆彦 (70384633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

UNO Yasuhiro 宇野 泰広

Uno Yasuhiro 宇野 泰広

宇野 泰広 ウノ ヤスヒロ

Research Projects

Research Products

Co-Researchers

獣医学での薬物代謝の研究基盤構築を目指した薬物代謝酵素の遺伝子多型の網羅的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Systematic identification and characterization of essential drug-metabolizing enzyme toward establishment of platform for drug metabolism research in veterinary speciesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

薬物代謝酵素フラビン含有モノオキシゲナーゼがもたらす薬物相互作用と疾病の個人差

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of chemical-induced toxicity in fetal livers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular and functional characterization of flavin-containing monooxygenases (FMO1?6) in tree shrews2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of cytochrome P450 2C18 and 2C76 in tree shrews: P450 2C18 effectively oxidizes typical human P450 2C9/2C19 chiral substrates warfarin and omeprazole with less stereoselectivity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transcript abundance of hepatic drug-metabolizing enzymes in two dog breeds compared with 14 species including humans2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel cytochrome P450 2C94 (CYP2C94) functionally metabolizes diclofenac and omeprazole in dogs2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Newly identified cytochrome P450 3A genes of tree shrews and pigs are expressed and encode functional enzymes2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Newly Identified Tree Shrew Cytochrome P450 2A13 (CYP2A13) is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog CYP2A13 and Pig CYP2A192023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel cytochrome P450 1 (CYP1) genes in tree shrews are expressed and encode functional drug-metabolizing enzymes2023

Author(s)

Journal Title

DOI

Data Source

UNO Yasuhiro 宇野泰広

Uno Yasuhiro 宇野泰広

宇野泰広ウノヤスヒロ