Okumura Hideo 奥村英夫

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OKUMURA Hideo 奥村英夫

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Researcher Number	90377903
Other IDs
Affiliation (Current)	2025: 公益財団法人高輝度光科学研究センター, 回折・散乱推進室, 研究員
Affiliation (based on the past Project Information) *help	2015 – 2018: 公益財団法人高輝度光科学研究センター, タンパク質結晶解析推進室, 研究員 2015: 公益財団法人高輝度光科学研究センター, タンパク質結晶解析推進室, 研究員 2014: 公益財団法人高輝度光科学研究センター, その他部局等, 研究員 2012 – 2013: 公益財団法人高輝度光科学研究センター, 利用研究促進部門, 研究員 2011: (財)高輝度光科学研究センター, 利用研究促進部門, 研究員 … More 2009: 独立行政法人理化学研究所, 化合物ライブラリー評価研究チーム, 基礎科学特別研究員 2006: Nagoya University, Graduate school of Science, Assistant Professor, 7・1より理化学研究所の協力研究員), 産学官連携研究員 2005: 名古屋大学, 大学院・理学研究科(H17・7・1より理化学研究所の協力研究員), 産学官連携研究員 Less
Review Section/Research Field	Principal Investigator Chemical biology Except Principal Investigator Applied microbiology / Chemical biology / Biophysics
Keywords	Principal Investigator 酵素反応 / 基質認識 / エステル化反応 / ケミカルバイオロジー / X線結晶構造解析 Except Principal Investigator ポリケチド / 放線菌 / リベロマイシン / 生合成 / 蛋白質 … More / BACベクター / 微生物 / 二次代謝産物 / ドメイン改変 / 機能ドメイン改変 / 異種発現 / ポリケチド合成酵素 / 抗がん剤 / がん / X-ray crystallography / retinal protein / membrane protein / chloride pump / proton pump / squid rhodopsin / halorhodopsin / bacteriorhodopsin / 分子機械 / 計算物理 / ナノバイオ / 生物物理 / レチナール蛋白質 / X線結晶構造解析 / レチナールタンパク質 / 膜タンパク質 / 塩素イオンポンプ / プロトンポンプ / ロドプシン / ハロロドプシン / バクテリオロドプシン / 結晶化 / 3級水酸基エステル化 / CoA リガーゼ / CoAリガーゼ / アルキルマロニルCoA / スピロアセタール / 標的分子 / 結晶構造解析 / 低分子化合物 / ライブラリー / 化合物アレイ / リガンド / 受容体 / 相互作用 / バイオプローブ / 構造生物学 / 化学生物学 Less

Modification of polyketide synthase and elucidation of enzyme reaction which is difficult in chemical synthesis, and creation of novel natural products
- Principal Investigator
  
  Takahashi Shunji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Institute of Physical and Chemical Research
Development of novel anti-cancer agents targeting de novo pyrimidine biosynthetic pathway
- Principal Investigator
  
  Kawatani Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Institute of Physical and Chemical Research
Construction of a biosynthetic logic toward a new era of natural product
- Principal Investigator
  
  Takahashi Shunji
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied microbiology
- Research Institution
  Institute of Physical and Chemical Research
Elucidation of succinyl transferase reaction mechanisms which is difficult to perform by organic synthesisPrincipal Investigator
- Principal Investigator
  
  OKUMURA Hideo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical biology
- Research Institution
  Japan Synchrotron Radiation Research Institute
Chemical proteomics to reveal interaction between chemicals and proteins at angstrom level
- Principal Investigator
  
  OSADA Hiroyuki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  The Institute of Physical and Chemical Research
Four Dimensional Structural Analysis of Biological Ion Pumps
- Principal Investigator
  
  KOUYAMA Tsutomu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University

All 2019 2018 2017 2009 2008 2007 2006 2005

All Journal Article Presentation Book

[Book] コンピューターモデリングによる最適化「がん分子標的治療研究実践マニュアル(日本がん分子標的治療学会編)」2009
- Author(s)
  奥村英夫, 他
- Total Pages
  340
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-17GS0221
[Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array.2009
- Author(s)
  Okumura, H. (8名中2番目), Osada, H. (8名中10番目)
- Journal Title
  
  Chembiochem 10
  
  Pages: 845-852
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17GS0221
[Journal Article] The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I.2008
- Author(s)
  Okumura, H. (11名中2番目), Osada, H. (11名中11番目)
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 11691-11696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17GS0221
[Journal Article] Crystal structures of archaerhodopsin-1 and -2 : Common structural motif in archaeal light-driven proton pumps2006
- Author(s)
  Enami, N., Yoshimura, K., Murakami, M., Okumura, H., Ihara, K., Kouyama, T.
- Journal Title
  
  J. Mol. Biol. 358
  
  Pages: 675-685
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17370056
[Journal Article] Crystal structures of archaerhodopsin-1 and-2 : Common structural motif in archaeal light-driven proton pumps2006
- Author(s)
  Enami, N.Yoshimura, K., Murakami, M., Okumura, H., Ihara, K., Kouyama, T.
- Journal Title
  
  J. Mol. Biol. 358
  
  Pages: 675-685
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17370056
[Journal Article] Crystal structures of archaerhodopsin-1 and -2 : Common structural motif in archaeal light-driven proton pumps2006
- Author(s)
  Enami, N., Yoshimura, K., Murakami, M., Okumura, H., Ihara, K., Kouyama, T.
- Journal Title
  
  J. Mol. Biol.
- Data Source
  KAKENHI-PROJECT-17370056
[Journal Article] Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells.2006
- Author(s)
  H.Okumura et al.
- Journal Title
  
  Toxicol.Lett. 166
  
  Pages: 44-52
- Data Source
  KAKENHI-PROJECT-17GS0221
[Journal Article] Crystal structures of archaerhodopsin-1 and -2 : Common structural motif in archaeal light-driven proton pumps2006
- Author(s)
  Enami, N., Yoshimura, K., Murakami, M., Okumura, H., Ihara, K., Kouyama, T.
- Journal Title
  
  J.Mol.Biol. (In press)
- Data Source
  KAKENHI-PROJECT-17370056
[Journal Article] Crystal structures of acid blue and, alkaline purple forms of bacteriorhodopsin2005
- Author(s)
  Okumura, H., Murakami, M., Kouyama, T.
- Journal Title
  
  J.Mol.Biol. 351
  
  Pages: 481-495
- Data Source
  KAKENHI-PROJECT-17370056
[Journal Article] Crystal structures of acid blue and alkaline purple forms of bacteriorhodopsin2005
- Author(s)
  Okumura, H.Murkami, M., Kouyama, T.
- Journal Title
  
  J. Mol. Biol. 351
  
  Pages: 481-495
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17370056
[Journal Article] Crystal structures of acid blue and alkaline purple forms of bacteriorhodopsin"2005
- Author(s)
  Okumura, H., Murkami, M., Kouyama, T.
- Journal Title
  
  J. Mol. Biol. 351
  
  Pages: 481-495
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17370056
[Presentation] リベロマイシン生合成に関わるサクシニル化酵素群の相互作用解析2019
- Author(s)
  鬼頭奈央子、佐藤裕美、奥村英夫、熊坂崇、長田裕之、高橋俊二
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] リベロマイシン生合成に関わるRevKの結晶構造解析2019
- Author(s)
  奥村英夫、鬼頭奈央子、佐藤裕美、熊坂崇、長田裕之、高橋俊二
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] リベロマイシン生合成に関わるサクシニル化酵素群の機能解析2018
- Author(s)
  鬼頭奈央子、高橋俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
- Organizer
  農芸化学会
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] リベロマイシン生合成に関わるRevMの機能解析2017
- Author(s)
  鬼頭奈央子、高橋俊二、佐藤裕美、奥村英夫、熊坂崇、長田裕之
- Organizer
  放線菌学会
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] リベロマイシン生合成に関わる酸化還元酵素RevMの機能解析2017
- Author(s)
  鬼頭奈央子、高橋俊二、宮澤岳、前島希、田中美帆、室井誠、奥村英夫、熊坂崇、長田裕之
- Organizer
  農芸化学会
- Place of Presentation
  京都（京都女子大）
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-16H04905
[Presentation] グリオキサラーゼIの阻害剤複合体の結晶構造2008
- Author(s)
  奥村英夫, 他
- Organizer
  2008年度第46回生物物理学会年会
- Place of Presentation
  福岡国際会議場(福岡)
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] Substrate recognition mechanism of NRPS A domain from Streptomyces2007
- Author(s)
  Okumura H., et. al.
- Organizer
  The 4th Takeda Science Foundation Symposium on PharmaSciences, On the Frontiers of Chemical Biology
- Place of Presentation
  Sheraton Miyako Hotel Tokyo
- Year and Date
  2007-12-03
- Data Source
  KAKENHI-PROJECT-17GS0221
[Presentation] 放線菌由来NRPSアデニレーションドメインのX線結晶構造解析2007
- Author(s)
  奥村英夫, 他
- Organizer
  日本生物物理学会第45回年会講演
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-21
- Data Source
  KAKENHI-PROJECT-17GS0221

1. TAKAHASHI Shunji (30311608)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. SHIMIZU Takeshi (80087569)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. YOSHIDA Minoru (80191617)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. OSADA Hiroyuki (80160836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. SAITO Akiko (40415162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SHIRO Yoshitsugu (70183051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KAKEYA Hideaki (00270596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. USUI Takeo (60281648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HAYASHI Yujiro (00198863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KOJIMA Soichi (10202061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KOUYAMA Tsutomu (30170210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
12. IHARA Kunio (90223297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. MURAKAMI Midori (20324387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
14. YAMATO Takahisa (90251587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Kawatani Makoto (50391925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. HIRANUMA Sayoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. WIERZBA Konstanty

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Okumura Hideo 奥村 英夫

OKUMURA Hideo 奥村 英夫

Research Projects

Research Products

Co-Researchers

Modification of polyketide synthase and elucidation of enzyme reaction which is difficult in chemical synthesis, and creation of novel natural products

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel anti-cancer agents targeting de novo pyrimidine biosynthetic pathway

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Construction of a biosynthetic logic toward a new era of natural product

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of succinyl transferase reaction mechanisms which is difficult to perform by organic synthesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemical proteomics to reveal interaction between chemicals and proteins at angstrom level

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Four Dimensional Structural Analysis of Biological Ion Pumps

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] コンピューターモデリングによる最適化「がん分子標的治療研究 実践マニュアル(日本がん分子標的治療学会 編)」2009

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Structure-affinity relationship study of bleomycins and Shble protein by use of a chemical array.2009

Author(s)

Journal Title

Data Source

[Journal Article] The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I.2008

Author(s)

Journal Title

Data Source

[Journal Article] Crystal structures of archaerhodopsin-1 and -2 : Common structural motif in archaeal light-driven proton pumps2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Crystal structures of archaerhodopsin-1 and-2 : Common structural motif in archaeal light-driven proton pumps2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Crystal structures of archaerhodopsin-1 and -2 : Common structural motif in archaeal light-driven proton pumps2006

Author(s)

Journal Title

Data Source

[Journal Article] Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells.2006

Author(s)

Journal Title

Data Source

[Journal Article] Crystal structures of archaerhodopsin-1 and -2 : Common structural motif in archaeal light-driven proton pumps2006

Author(s)

Journal Title

Data Source

[Journal Article] Crystal structures of acid blue and, alkaline purple forms of bacteriorhodopsin2005

Author(s)

Journal Title

Data Source

[Journal Article] Crystal structures of acid blue and alkaline purple forms of bacteriorhodopsin2005

Okumura Hideo 奥村英夫

OKUMURA Hideo 奥村英夫

[Book] コンピューターモデリングによる最適化「がん分子標的治療研究実践マニュアル(日本がん分子標的治療学会編)」2009