Demizu Yousuke 出水庸介

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DEMIZU Yosuke 出水庸介

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Researcher Number	90389180
Other IDs	https://orcid.org/0000-0001-7521-4861
Affiliation (Current)	2024: 国立医薬品食品衛生研究所, 有機化学部, 部長 2024: 横浜市立大学, 生命医科学研究科, 客員教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 国立医薬品食品衛生研究所, 有機化学部, 部長 2014 – 2016: 国立医薬品食品衛生研究所, 有機化学部, 室長 2015: 国立医薬品食品研究所, 有機化学部, 室長 2012: 国立医薬品食品衛生研究所, 有機化学部 2008 – 2010: National Institute of Health Sciences, 有機化学部, 研究官 … More 2008: National Institute of Health Sciences, 研究官 2007: Nagasaki University, 大学院・医歯薬学総合研究科, 助教 2006: 長崎大学, 大学院医歯薬学総合研究科, 助手 2005: 徳島文理大学, 香川薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Chemical pharmacy / Drug development chemistry / Transformative Research Areas, Section (III) / Basic Section 37030:Chemical biology-related Except Principal Investigator Complex systems / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Biological pharmacy / Tumor therapeutics / Drug development chemistry
Keywords	Principal Investigator ペプチド / ヘリカル構造 / 非天然型アミノ酸 / DDSキャリア / PPI阻害 / 中分子ペプチド / PROTAC / タンパク質分解誘導剤 / フォルダマー / アミノ酸 … More / 二次構造 / E3アダプタータンパク質 / E3ユビキチンリガーゼ / アプタマー / CRBNモジュレーター / ヘリックス / 転写関連因子 / ヘリカルペプチド / タンパク質間相互作用阻害剤 / アンチセンス核酸 / 二次構造解析 / Post-modification / 核内受容体 / 分解誘導剤 / 構造制御 / ステープルペプチド / 抗菌ペプチド / DDS / 二次構造制御 / 癌 / プロテインノックダウン / 膜透過ペプチド / Hisタグタンパク質 / ユビキチン-プロテアソームシステム / 細胞膜透過性ペプチド / 標的タンパク質分解誘導剤 / PPI阻害剤 / ペプチド触媒 / コンフォメーション / 環状アミン / 酸化反応 / 電極反応 / N-オキシル / フォールダマー / 電極酸化 / 計算化学 / 3_<10>-ヘリックス / α-ヘリックス / フォールドマー / α,α-ジ置換アミノ酸 … More Except Principal Investigator ユビキチン / ペプチド / ステープルペプチド / タンパク質分解 / 人工塩基 / アンチジーン / ペプチド核酸 / プロテアソーム / SNIPER / エストロゲン受容体 / ヘリカルペプチド / 擬似相補性 / シグナル伝達 / タンパク質化学合成 / 標的タンパク質分解誘導剤 / 翻訳後修飾 / ケミカルバイオロジー / IAP / 脱ユビキチン化酵素 / 血管新生 / セレブロン / デコイ核酸 / セレブロンモジュレーター / ケミカルプロテインノックダウン / 固相合成 / アプタマーPROTAC / 神経変性疾患 / がん / 催奇性 / CRBN / サリドマイド / PROTAC / 人工核酸 / ゲノム / ストランドインベージョン / 有機化学 / 核酸医薬 / 蛋白質 / 核内受容体 / 蛋白質分解 / Notch / プロテインノックダウン / エストロゲンレセプター / 乳癌 / ビタミンDレセプター / 転写阻害 / ビタミンＤレセプター / ヘリックス / コアクチベータ / 核内レセプター Less

Controlling the lifetime of proteins using chemical degradersPrincipal Investigator
- Principal Investigator
  
  出水庸介
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  National Institute of Health Sciences
Molecular design and synthesis of pseudo-complementary peptide nucleic acids capable of strand invasion without restriction
- Principal Investigator
  
  杉山亨
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Teikyo University
革新的中分子医薬品創出を目指したペプチドフォルダマー研究Principal Investigator
- Principal Investigator
  
  出水庸介
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  National Institute of Health Sciences
Design and synthesis of peptide nucleic acids toward overcoming sequence restrictions in strand invasion
- Principal Investigator
  
  SUGIYAMA TORU
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Teikyo University
Chemical protein knockdown technology and cell regulation
- Principal Investigator
  
  Naito Mikihiko
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
  National Institute of Health Sciences
New frontier for ubiquitin biology driven by chemo-technologies
- Principal Investigator
  
  SAEKI Yasushi
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Peptide foldamers in drug discoveryPrincipal Investigator
- Principal Investigator
  
  Demizu Yosuke
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Design of peptide ligands based on protein-protein interaction and their application to protein knockdown technology
- Principal Investigator
  
  Naito Mikihiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health Sciences
Development of stabilized helical peptides as POI degradation inducersPrincipal Investigator
- Principal Investigator
  
  DEMIZU YOSUKE
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Development of estrogen receptor degrader and analysis of drug-induced cell death mechanism for breast cancer therapy
- Principal Investigator
  
  OKUHIRA Keiichiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  The University of Tokushima
  National Institute of Health Sciences
Design of a stabilized short helical peptide and its application
- Principal Investigator
  
  KURIHARA Masaaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Design of proline analogues based on hybrid methods and their applicationPrincipal Investigator
- Principal Investigator
  
  DEMIZU Yosuke
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  National Institute of Health Sciences
Design and synthesis of non-proteinogenic amino acids and peptide foldamers by anodic functionalizatonPrincipal Investigator
- Principal Investigator
  
  DEMIZU Yosuke
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  National Institute of Health Sciences
  Nagasaki University
ペプチド-フォールドマーのナノ二次構造を利用した機能性分子の創製Principal Investigator
- Principal Investigator
  
  出水庸介
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Nagasaki University
  Tokushima Bunri University

[Book] 次世代医薬とバイオ医療　第２章ペプチド医薬およびペプチド様医薬2022
- Author(s)
  出水庸介，大庭誠（長野哲雄、川西徹編）
- Total Pages
  272
- Publisher
  東京化学同人
- ISBN
  9784807920181
- Data Source
  KAKENHI-PLANNED-18H05502
[Book] Cell-Penetrating Peptides: Design, Development and Applications2022
- Author(s)
  M. Oba, Y. Demizu
- Total Pages
  416
- Publisher
  WILEY-VCH
- ISBN
  9783527350117
- Data Source
  KAKENHI-PROJECT-21K05320
[Book] Cell-Penetrating Peptides: Design, Development and Applications2022
- Author(s)
  Oba M, Demizu Y.
- Total Pages
  416
- Publisher
  WILEY-VCH
- Data Source
  KAKENHI-PLANNED-18H05502
[Book] ペプチド創薬の最前線，第5章「二次構造制御を基軸としたペプチド創薬研究」2019
- Author(s)
  出水庸介
- Total Pages
  265
- Publisher
  CMC出版
- ISBN
  9784781314174
- Data Source
  KAKENHI-PROJECT-17K08385
[Book] 医薬品開発における中分子領域(核酸医薬・ペプチド医薬)の開発戦略，「ペプチド医薬品の品質に関するガイドラインおよび規制の現状」2019
- Author(s)
  出水庸介，石井明子
- Total Pages
  206
- Publisher
  情報機構
- ISBN
  9784865021769
- Data Source
  KAKENHI-PROJECT-17K08385
[Journal Article] Current Status of Oligonucleotide-Based Protein Degraders2023
- Author(s)
  Po-Chang Shih, Miyako Naganuma, Yosuke Demizu, Mikihiko Naito
- Journal Title
  
  Pharmaceutics
  
  Volume: 15 Issue: 3 Pages: 765-765
- DOI
  10.3390/pharmaceutics15030765
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KJ2565, KAKENHI-PROJECT-22KF0090, KAKENHI-PLANNED-18H05502
[Journal Article] Investigating the cell permeability of proteolysis-targeting chimeras (PROTACs)2023
- Author(s)
  Yokoo Hidetomo、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  Expert Opinion on Drug Discovery
  
  Volume: 18 Issue: 4 Pages: 357-361
- DOI
  10.1080/17460441.2023.2187047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15257, KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502
[Journal Article] CRBN ligand expansion for hematopoietic prostaglandin D2 synthase (H-PGDS) targeting PROTAC design and their in vitro ADME profiles2023
- Author(s)
  Osawa Hinata、Kurohara Takashi、Ito Takahito、Shibata Norihito、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 84 Pages: 117259-117259
- DOI
  10.1016/j.bmc.2023.117259
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] In silico optimization of peptides that inhibit Wnt/β-catenin signaling2023
- Author(s)
  Fujita Minami、Tsuchiya Keisuke、Kurohara Takashi、Fukuhara Kiyoshi、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 84 Pages: 117264-117264
- DOI
  10.1016/j.bmc.2023.117264
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Oligoarginine-Conjugated Peptide Foldamers Inhibiting Vitamin D Receptor-Mediated Transcription2022
- Author(s)
  Takyo Mami、Sato Yumi、Hirata Naoya、Tsuchiya Keisuke、Ishida Hiroaki、Kurohara Takashi、Yanase Yuta、Ito Takahito、Kanda Yasunari、Yamamoto Keiko、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  ACS Omega
  
  Volume: 7 Issue: 50 Pages: 46573-46582
- DOI
  10.1021/acsomega.2c05409
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06958, KAKENHI-PROJECT-21K05320, KAKENHI-PLANNED-18H05502
[Journal Article] Development of a penetratin-conjugated stapled peptide that inhibits Wnt/β-catenin signaling2022
- Author(s)
  Tsuchiya Keisuke、Kiyoshi Masato、Hashii Noritaka、Fujita Minami、Kurohara Takashi、Ishii-Watabe Akiko、Fukuhara Kiyoshi、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 73 Pages: 117021-117021
- DOI
  10.1016/j.bmc.2022.117021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06958, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K06508, KAKENHI-PLANNED-18H05502
[Journal Article] Organocatalytic Synthesis of Phenols from Diaryliodonium Salts with Water under Metal-Free Conditions2022
- Author(s)
  Katagiri Kotone、Kuriyama Masami、Yamamoto Kosuke、Demizu Yosuke、Onomura Osamu
- Journal Title
  
  Organic Letters
  
  Volume: 24 Issue: 28 Pages: 5149-5154
- DOI
  10.1021/acs.orglett.2c01989
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K06528
[Journal Article] Helical Foldamers and Stapled Peptides as New Modalities in Drug Discovery: Modulators of Protein-Protein Interactions2022
- Author(s)
  Tsuchiya Keisuke、Kurohara Takashi、Fukuhara Kiyoshi、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Processes
  
  Volume: 10 Issue: 5 Pages: 924-924
- DOI
  10.3390/pr10050924
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06958, KAKENHI-PROJECT-21K05320, KAKENHI-PLANNED-18H05502
[Journal Article] Development of delivery carriers for plasmid DNA by conjugation of a helical template to oligoarginine2022
- Author(s)
  Yokoo Hidetomo、Misawa Takashi、Kato Takuma、Tanaka Masakazu、Demizu Yosuke、Oba Makoto
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 72 Pages: 116997-116997
- DOI
  10.1016/j.bmc.2022.116997
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K15257
[Journal Article] Analysis of the interaction of cyclosporine congeners with cell membrane models2022
- Author(s)
  Nakao Mizuka、Takechi-Haraya Yuki、Ohgita Takashi、Saito Hiroyuki、Demizu Yosuke、Izutsu Ken-Ichi、Sakai-Kato Kumiko
- Journal Title
  
  Journal of Pharmaceutical and Biomedical Analysis
  
  Volume: 218 Pages: 114874-114874
- DOI
  10.1016/j.jpba.2022.114874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K06556
[Journal Article] Molecular Design, Synthesis, and Evaluation of SNIPER (ER) that Induces Targeted Protein Degradation of ERα2022
- Author(s)
  Ohoka N, Yokoo H, Okuhira K, Demizu Y, Naito M.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 2418 Pages: 363-382
- DOI
  10.1007/978-1-0716-1920-9_20
- ISBN
  9781071619193, 9781071619209
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-21K05320, KAKENHI-PLANNED-18H05502
[Journal Article] Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles2022
- Author(s)
  Xu Hanqiao、Kurohara Takashi、Takano Reina、Yokoo Hidetomo、Shibata Norihito、Ohoka Nobumichi、Inoue Takao、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  ChemistryOpen
  
  Volume: 11 Issue: 7
- DOI
  10.1002/open.202200131
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06075, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502
[Journal Article] Copper-Catalyzed Asymmetric Oxidative Desymmetrization of 2-Substituted 1,2,3-Triols2022
- Author(s)
  Yamamoto Kosuke、Suganomata Yu、Inoue Takumi、Kuriyama Masami、Demizu Yosuke、Onomura Osamu
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 87 Issue: 9 Pages: 6479-6491
- DOI
  10.1021/acs.joc.2c00398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05459, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K15255
[Journal Article] Structure?activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthase2022
- Author(s)
 Murakami Yuki、Osawa Hinata、Kurohara Takashi、Yanase Yuta、Ito Takahito、Yokoo Hidetomo、Shibata Norihito、Naito Mikihiko、Aritake Kosuke、Demizu Yosuke
- Journal Title
 
 RSC Medicinal Chemistry
 
 Volume: 13 Issue: 12 Pages: 1495-1503
- DOI
 10.1039/d2md00284a
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06075, KAKENHI-PLANNED-18H05502
[Journal Article] Structure?Activity Relationship Studies of Substitutions of Cationic Amino Acid Residues on Antimicrobial Peptides2022
- Author(s)
  Takada Mayu、Ito Takahito、Kurashima Megumi、Matsunaga Natsumi、Demizu Yosuke、Misawa Takashi
- Journal Title
  
  Antibiotics
  
  Volume: 12 Issue: 1 Pages: 19-19
- DOI
  10.3390/antibiotics12010019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] PreQ1 facilitates DNA strand invasion by PNA2022
- Author(s)
  Shun-suke Moriya, Yuki Yoneta, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Atsushi Kittaka, and Toru Sugiyama
- Journal Title
  
  Peptide Science
  
  Volume: 2021 Pages: 111-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06557
[Journal Article] The effects of magainin 2-derived and rationally designed antimicrobial peptides on Mycoplasma pneumoniae2022
- Author(s)
  Hayashi Katsuhiko、Misawa Takashi、Goto Chihiro、Demizu Yosuke、Hara-Kudo Yukiko、Kikuchi Yutaka
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 1 Pages: e0261893-e0261893
- DOI
  10.1371/journal.pone.0261893
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16366, KAKENHI-PROJECT-21K05320
[Journal Article] Development of Gilteritinib-Based Chimeric Small Molecules that Potently Induce Degradation of FLT3-ITD Protein2022
- Author(s)
  Ohoka Nobumichi、Suzuki Masanori、Uchida Takuya、Tsuji Genichiro、Tsukumo Yoshinori、Yoshida Masayuki、Inoue Takao、Demizu Yosuke、Ohki Hitoshi、Naito Mikihiko
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 13 Issue: 12 Pages: 1885-1891
- DOI
  10.1021/acsmedchemlett.2c00402
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-19K07724, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502
[Journal Article] Recent Advances in PROTAC Technology Toward New Therapeutic Modalities2022
- Author(s)
  Yokoo Hidetomo、Naganuma Miyako、Oba Makoto、Demizu Yosuke
- Journal Title
  
  Chemistry & Biodiversity
  
  Volume: 19 Issue: 11 Pages: 134-139
- DOI
  10.1002/cbdv.202200828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K15257, KAKENHI-PROJECT-22KJ2565, KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502
[Journal Article] Current Status and Challenges of Analytical Methods for Evaluation of Size and Surface Modification of Nanoparticle-Based Drug Formulations2022
- Author(s)
  Takechi-Haraya Yuki、Ohgita Takashi、Demizu Yosuke、Saito Hiroyuki、Izutsu Ken-ichi、Sakai-Kato Kumiko
- Journal Title
  
  AAPS PharmSciTech
  
  Volume: 23 Issue: 5 Pages: 150-150
- DOI
  10.1208/s12249-022-02303-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05320
[Journal Article] Control of STING Agonistic/Antagonistic Activity Using Amine-Skeleton-Based c-di-GMP Analogues2022
- Author(s)
  Yanase Yuta、Tsuji Genichiro、Nakamura Miki、Shibata Norihito、Demizu Yosuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 12 Pages: 6847-6847
- DOI
  10.3390/ijms23126847
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-19K16333
[Journal Article] Antiviral activity of ciclesonide acetal derivatives blocking SARS-CoV-2 RNA replication2022
- Author(s)
  Tsuji Genichiro、Nakajima Shogo、Watashi Koichi、Torii Shiho、Suzuki Rigel、Fukuhara Takasuke、Ohoka Nobumichi、Inoue Takao、Demizu Yosuke
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 149 Issue: 3 Pages: 81-84
- DOI
  10.1016/j.jphs.2022.04.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K15458, KAKENHI-PROJECT-21H02736
[Journal Article] Fcγ Receptor-Dependent Internalization and Off-Target Cytotoxicity of Antibody-Drug Conjugate Aggregates2022
- Author(s)
  Aoyama Michihiko、Tada Minoru、Yokoo Hidetomo、Demizu Yosuke、Ishii-Watabe Akiko
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 39 Issue: 1 Pages: 89-103
- DOI
  10.1007/s11095-021-03158-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05320
[Journal Article] Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors2022
- Author(s)
  Irie Tomohiko、Yanase Yuta、Demizu Yosuke、Usami Makoto、Kikura-Hanajiri Ruri
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 150 Issue: 4 Pages: 233-243
- DOI
  10.1016/j.jphs.2022.09.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-22K06838, KAKENHI-PROJECT-19K07295
[Journal Article] Helix-Stabilized Cell-Penetrating Peptides for Delivery of Antisense Morpholino Oligomers: Relationships among Helicity, Cellular Uptake, and Antisense Activity2022
- Author(s)
  Takada Hiroyuki、Tsuchiya Keisuke、Demizu Yosuke
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 33 Issue: 7 Pages: 1311-1318
- DOI
  10.1021/acs.bioconjchem.2c00199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K05320, KAKENHI-PLANNED-18H05502
[Journal Article] Peptide Stapling Improves the Sustainability of a Peptide-Based Chimeric Molecule That Induces Targeted Protein Degradation2021
- Author(s)
  Yokoo Hidetomo、Ohoka Nobumichi、Takyo Mami、Ito Takahito、Tsuchiya Keisuke、Kurohara Takashi、Fukuhara Kiyoshi、Inoue Takao、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 16 Pages: 8772-8772
- DOI
  10.3390/ijms22168772
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-20K22711
[Journal Article] Development of Agonist-Based PROTACs Targeting Liver X Receptor2021
- Author(s)
  Xu Hanqiao、Ohoka Nobumichi、Yokoo Hidetomo、Nemoto Kanako、Ohtsuki Takashi、Matsufuji Hiroshi、Naito Mikihiko、Inoue Takao、Tsuji Genichiro、Demizu Yosuke
- Journal Title
  
  Frontiers in Chemistry
  
  Volume: 9 Pages: 674967-674967
- DOI
  10.3389/fchem.2021.674967
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K05320
[Journal Article] Approach to Establishment of Control Strategy for Oral Solid Dosage Forms Using Continuous Manufacturing2021
- Author(s)
  Ishimoto Hayato、Kano Manabu、Sugiyama Hirokazu、Takeuchi Hirofumi、Terada Katsuhide、Aoyama Atsushi、Shoda Takuji、Demizu Yosuke、Shimamura Jinen、Yokoyama Reiji、Miyamoto Yuji、Hasegawa Koji、Serizawa Masaru、Unosawa Kazuomi、Osaki Kazuo、Asai Naochika、Matsuda Yoshihiro
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 69 Issue: 2 Pages: 211-217
- DOI
  10.1248/cpb.c20-00824
- NAID
  130007979432
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2021-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07009, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer2021
- Author(s)
  Yokoo Hidetomo、Shibata Norihito、Naganuma Miyako、Murakami Yuki、Fujii Kiyonaga、Ito Takahito、Aritake Kosuke、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 12 Issue: 2 Pages: 236-241
- DOI
  10.1021/acsmedchemlett.0c00605
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07311, KAKENHI-PROJECT-20K22711, KAKENHI-PROJECT-17K08385, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K05320
[Journal Article] Nickel-Catalyzed Hydrodeoxygenation of Aryl Sulfamates with Alcohols as Mild Reducing Agents2021
- Author(s)
  Kuriyama Masami、Onomura Osamu、Matsuo Kasumi、Yamamoto Kosuke、Demizu Yosuke、Nishida Koyo
- Journal Title
  
  Synthesis
  
  Volume: 53 Issue: 23 Pages: 4449-4460
- DOI
  10.1055/a-1548-8362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06582, KAKENHI-PROJECT-19K05459, KAKENHI-PROJECT-21K05320
[Journal Article] Development of Chimeric Molecules That Degrade the Estrogen Receptor Using Decoy Oligonucleotide Ligands2021
- Author(s)
  Naganuma M, Ohoka N, Tsuji G, Tsujimura H, Matsuno K, Inoue T, Naito M, Demizu Y.
- Journal Title
  
  ACS Med Chem Lett.
  
  Volume: 13 Issue: 1 Pages: 134-139
- DOI
  10.1021/acsmedchemlett.1c00629
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-21K06490, KAKENHI-PROJECT-22KJ2565, KAKENHI-PROJECT-21K05320, KAKENHI-PLANNED-18H05502
[Journal Article] Protocols for Synthesis of and the Methods to Evaluate the Anticancer Effects2021
- Author(s)
  Tsukumo Yoshinori、Tsuji Genichiro、Yokoo Hidetomo、Shibata Norihito、Ohoka Nobumichi、Demizu Yosuke、Naito Mikihiko
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 2365 Pages: 331-347
- DOI
  10.1007/978-1-0716-1665-9_18
- ISBN
  9781071616642, 9781071616659
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-19K07724, KAKENHI-PROJECT-21K05320
[Journal Article] Synthesis of Norgestomet and its 17β-isomer and evaluation of their agonistic activities against progesterone receptor2021
- Author(s)
  Kurohara Takashi、Ito Takahito、Tsuji Genichiro、Misawa Takashi、Yokoo Hidetomo、Yanase Yuta、Shoda Takuji、Sakai Takatoshi、Hosoe Junko、Uchiyama Nahoko、Akiyama Hiroshi、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 49 Pages: 116425-116425
- DOI
  10.1016/j.bmc.2021.116425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Changes in Test Methods for Internationalization in the Japanese Pharmacopoeia (Part 2): Establishment of a Quantitative Method for Lorazepam Using HPLC Analysis2021
- Author(s)
  Maniwa Aika、Tsuji Genichiro、Ito Takahito、Uchiyama Nahoko、Hosoe Junko、Ohtsuki Takashi、Matsufuji Hiroshi、Demizu Yosuke、Goda Yukihiro
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 141 Issue: 7 Pages: 961-970
- DOI
  10.1248/yakushi.21-00010
- NAID
  130008059963
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2021-07-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Synthesis and characterization of PNA oligomers containing preQ1 as a positively charged guanine analogue2021
- Author(s)
  Moriya Shun-suke、Shibasaki Hatsune、Kohara Misaki、Kuwata Keiko、Imamura Yasutada、Demizu Yosuke、Kurihara Masaaki、Kittaka Atsushi、Sugiyama Toru
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 39 Pages: 127850-127850
- DOI
  10.1016/j.bmcl.2021.127850
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-18K06557, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Discovery of a Highly Potent and Selective Degrader Targeting Hematopoietic Prostaglandin D Synthase via In Silico Design2021
- Author(s)
  Yokoo Hidetomo、Shibata Norihito、Endo Akinori、Ito Takahito、Yanase Yuta、Murakami Yuki、Fujii Kiyonaga、Hamamura Kengo、Saeki Yasushi、Naito Mikihiko、Aritake Kosuke、Demizu Yosuke
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 21 Pages: 15868-15882
- DOI
  10.1021/acs.jmedchem.1c01206
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K07311, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21H02777, KAKENHI-PROJECT-20K06568, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-21K11613, KAKENHI-PROJECT-20K22711
[Journal Article] Structure?activity relationship study of amphipathic antimicrobial peptides using helix‐destabilizing sarcosine2021
- Author(s)
  Yokoo Hidetomo、Hirano Motoharu、Ohoka Nobumichi、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Journal of Peptide Science
  
  Volume: 27 Issue: 12 Pages: 1-6
- DOI
  10.1002/psc.3360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-20K22711
[Journal Article] Changes in Test Methods for Internationalization in the Japanese Pharmacopoeia (Part 1): Establishment of a Quantitative Test Method for Clonidine Hydrochloride Using HPLC Analysis2021
- Author(s)
  Maniwa Aika、Tsuji Genichiro、Ito Takahito、Uchiyama Nahoko、Hosoe Junko、Ohtsuki Takashi、Matsufuji Hiroshi、Demizu Yosuke、Goda Yukihiro
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 141 Issue: 4 Pages: 591-598
- DOI
  10.1248/yakushi.20-00237
- NAID
  130008013879
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2021-04-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Design and synthesis of novel estrogen receptor antagonists with acetal containing biphenylmethane skeleton2021
- Author(s)
  Yuyama Materu、Misawa Takashi、Demizu Yosuke、Kanaya Takayuki、Kurihara Masaaki
- Journal Title
  
  Results in Chemistry
  
  Volume: 3 Pages: 100124-100124
- DOI
  10.1016/j.rechem.2021.100124
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] N-Nitrosodimethylamine (NDMA) Formation from Ranitidine Impurities: Possible Root Causes of the Presence of NDMA in Ranitidine Hydrochloride2021
- Author(s)
 Yokoo Hidetomo、Yamamoto Eiichi、Masada Sayaka、Uchiyama Nahoko、Tsuji Genichiro、Hakamatsuka Takashi、Demizu Yosuke、Izutsu Ken-ichi、Goda Yukihiro
- Journal Title
 
 Chemical and Pharmaceutical Bulletin
 
 Volume: 69 Issue: 9 Pages: 872-876
- DOI
 10.1248/cpb.c21-00289
- NAID
 130008081978
- ISSN
 0009-2363, 1347-5223
- Year and Date
 2021-09-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Amine skeleton-based c-di-GMP derivatives as biofilm formation inhibitors2021
- Author(s)
  Ikeda Kentaro、Yanase Yuta、Hayashi Katsuhiko、Hara-Kudo Yukiko、Tsuji Genichiro、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 32 Pages: 127713-127713
- DOI
  10.1016/j.bmcl.2020.127713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16333, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Development of ciclesonide analogues that block SARS-CoV-2 RNA replication2021
- Author(s)
  Tsuji Genichiro、Yonemitsu Kenzo、Ito Takahito、Yanase Yuta、Uema Masashi、Ohoka Nobumichi、Inoue Takao、Asakura Hiroshi、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 43 Pages: 128052-128052
- DOI
  10.1016/j.bmcl.2021.128052
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence2021
- Author(s)
  Hirano Motoharu、Saito Chihiro、Yokoo Hidetomo、Goto Chihiro、Kawano Ryuji、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 2 Pages: 444-444
- DOI
  10.3390/molecules26020444
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18K14880, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Discovery of non-proteinogenic amino acids inhibiting biofilm formation by S. aureus and methicillin-resistant S. aureus2021
- Author(s)
  Ikeda Kentaro、Shoda Takuji、Demizu Yosuke、Tsuji Genichiro
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 48 Pages: 128259-128259
- DOI
  10.1016/j.bmcl.2021.128259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320, KAKENHI-PROJECT-19K16333
[Journal Article] TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains2021
- Author(s)
  Kaiho-Soma Ai、Akizuki Yoshino、Igarashi Katsuhide、Endo Akinori、Shoda Takuji、Kawase Yasuko、Demizu Yosuke、Naito Mikihiko、Saeki Yasushi、Tanaka Keiji、Ohtake Fumiaki
- Journal Title
  
  Molecular Cell
  
  Volume: 81 Issue: 7 Pages: 1411-1424.e7
- DOI
  10.1016/j.molcel.2021.01.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07009, KAKENHI-PROJECT-17H01882, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K22726, KAKENHI-PROJECT-17H03986, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-21H03604, KAKENHI-PROJECT-21K05320
[Journal Article] Targeted Protein Degrader合成の戦略2021
- Author(s)
  横尾英知、出水庸介
- Journal Title
  
  細胞
  
  Volume: 53 Pages: 148-151
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Miroestrol Quantification in Pueraria mirifica Crude Drugs and Products by Single-Reference UPLC/PDA/MS Using Relative Molar Sensitivities to Kwakhurin2021
- Author(s)
 Masada Sayaka、Hosoe Junko、Arai Ryoko、Demizu Yosuke、Hakamatsuka Takashi、Goda Yukihiro、Uchiyama Nahoko
- Journal Title
 
 Chemical and Pharmaceutical Bulletin
 
 Volume: 69 Issue: 6 Pages: 573-580
- DOI
 10.1248/cpb.c21-00160
- NAID
 130008046432
- ISSN
 0009-2363, 1347-5223
- Year and Date
 2021-06-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Transition Metal-Free O-Arylation of Quinoxalin-2-ones with Diaryliodonium Salts2021
- Author(s)
  Kuriyama Msami、Mochizuki Yuki、Miyagi, Tsubasa、Yamamoto Kosuke、Demizu Yosuke、Onomura Osamu
- Journal Title
  
  Heterocycles
  
  Volume: 103 Issue: 1 Pages: 502-502
- DOI
  10.3987/com-20-s(k)26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05459, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Helical Antimicrobial Peptide Foldamers Containing Non‐proteinogenic Amino Acids2021
- Author(s)
  Yokoo Hidetomo、Hirano Motoharu、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  ChemMedChem
  
  Volume: 16 Issue: 8 Pages: 1226-1233
- DOI
  10.1002/cmdc.202000940
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18K14880, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Critical role of mitochondrial ubiquitination and the OPTN?ATG9A axis in mitophagy2020
- Author(s)
  Yamano Koji、Kikuchi Reika、Kojima Waka、Hayashida Ryota、Koyano Fumika、Kawawaki Junko、Shoda Takuji、Demizu Yosuke、Naito Mikihiko、Tanaka Keiji、Matsuda Noriyuki
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 219 Issue: 9 Pages: 1-23
- DOI
  10.1083/jcb.201912144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05500, KAKENHI-PLANNED-18H05502, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06237, KAKENHI-ORGANIZER-18H05497
[Journal Article] Development of Selective TGR5 Ligands Based on the 5,6,7,8‐Tetrahydro‐5,5,8,8‐tetramethylnaphthalene Skeleton2020
- Author(s)
  Terui Ryusei、Yanase Yuta、Yokoo Hidetomo、Suhara Yoshitomo、Makishima Makoto、Demizu Yosuke、Misawa Takashi
- Journal Title
  
  ChemMedChem
  
  Volume: 16 Issue: 3 Pages: 458-462
- DOI
  10.1002/cmdc.202000567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K22711, KAKENHI-PROJECT-18K14880, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-21K05320
[Journal Article] Facile Synthesis of Kwakhurin, a Marker Compound of Pueraria mirifica and Its Quantitative NMR Analysis for Standardization as a Reagent2020
- Author(s)
 Tsuji Genichiro、Yusa Masaaki、Masada Sayaka、Yokoo Hidetomo、Hosoe Junko、Hakamatsuka Takashi、Demizu Yosuke、Uchiyama Nahoko
- Journal Title
 
 Chemical and Pharmaceutical Bulletin
 
 Volume: 68 Issue: 8 Pages: 797-801
- DOI
 10.1248/cpb.c20-00346
- NAID
 130007883280
- ISSN
 0009-2363, 1347-5223
- Year and Date
 2020-08-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-17K08385
[Journal Article] Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors2020
- Author(s)
  Yokoo Hidetomo、Ohoka Nobumichi、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Issue: 15 Pages: 115595-115595
- DOI
  10.1016/j.bmc.2020.115595
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PLANNED-18H05502
[Journal Article] De Novo Design of Cell‐Penetrating Foldamers2020
- Author(s)
  Yokoo Hidetomo、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  The Chemical Record
  
  Volume: 20 Issue: 9 Pages: 912-921
- DOI
  10.1002/tcr.202000047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18K14880
[Journal Article] Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs2020
- Author(s)
  Ishikawa Minoru、Tomoshige Shusuke、Demizu Yosuke、Naito Mikihiko
- Journal Title
  
  Pharmaceuticals
  
  Volume: 13 Issue: 4 Pages: 74-74
- DOI
  10.3390/ph13040074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K16326, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551, KAKENHI-ORGANIZER-18H05497
[Journal Article] Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety.2020
- Author(s)
  Shoda T, Ohoka N, Tsuji G, Fujisato T, Inoue H, Demizu Y, Naito M, Kurihara M.
- Journal Title
  
  Pharmaceuticals (Basel).
  
  Volume: 13 Issue: 3 Pages: 34-34
- DOI
  10.3390/ph13030034
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05502, KAKENHI-ORGANIZER-18H05497
[Journal Article] Synthesis of Chiral α‐Trifluoromethyl α,α‐Disubstituted α‐Amino Acids and Conformational Analysis of L‐Leu‐Based Peptides with ( R )‐ or ( S )‐α‐Trifluoromethylalanine2020
- Author(s)
  Ueda Atsushi、Ikeda Misuzu、Kasae Takuya、Doi Mitsunobu、Demizu Yosuke、Oba Makoto、Tanaka Masakazu
- Journal Title
  
  ChemistrySelect
  
  Volume: 5 Issue: 35 Pages: 10882-10886
- DOI
  10.1002/slct.202002888
- NAID
  120006988512
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K06967, KAKENHI-PROJECT-17K19495, KAKENHI-PROJECT-18K14870
[Journal Article] Design, Synthesis, and Biological Activity of Conformationally Restricted Analogues of Silibinin2020
- Author(s)
  Mizuno Mirei、Mori Kazunori、Tsuchiya Keisuke、Takaki Takashi、Misawa Takashi、Demizu Yosuke、Shibanuma Motoko、Fukuhara Kiyoshi
- Journal Title
  
  ACS Omega
  
  Volume: 5 Issue: 36 Pages: 23164-23174
- DOI
  10.1021/acsomega.0c02936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-18K06588
[Journal Article] Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells2020
- Author(s)
  Shibata Norihito、Ohoka Nobumichi、Tsuji Genichiro、Demizu Yosuke、Miyawaza Keiji、Ui-Tei Kumiko、Akiyama Tetsu、Naito Mikihiko
- Journal Title
  
  Oncogene
  
  Volume: - Issue: 19 Pages: 3867-3878
- DOI
  10.1038/s41388-020-1253-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537, KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502, KAKENHI-ORGANIZER-18H05497
[Journal Article] Rational Design of Helix‐Stabilized Antimicrobial Peptide Foldamers Containing α,α‐Disubstituted Amino Acids or Side‐Chain Stapling2020
- Author(s)
  Hirano Motoharu、Saito Chihiro、Goto Chihiro、Yokoo Hidetomo、Kawano Ryuji、Misawa Takashi、Demizu Yosuke
- Journal Title
  
  ChemPlusChem
  
  Volume: 85 Issue: 12 Pages: 2731-2736
- DOI
  10.1002/cplu.202000749
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K22711, KAKENHI-PROJECT-18K14880
[Journal Article] Temperature-Dependent Formation of N-Nitrosodimethylamine during the Storage of Ranitidine Reagent Powders and Tablets2020
- Author(s)
 Abe Yasuhiro、Yamamoto Eiichi、Yoshida Hiroyuki、Usui Akiko、Tomita Naomi、Kanno Hitomi、Masada Sayaka、Yokoo Hidetomo、Tsuji Genichiro、Uchiyama Nahoko、Hakamatsuka Takashi、Demizu Yosuke、Izutsu Ken-ichi、Goda Yukihiro、Okuda Haruhiro
- Journal Title
 
 Chemical and Pharmaceutical Bulletin
 
 Volume: 68 Issue: 10 Pages: 1008-1012
- DOI
 10.1248/cpb.c20-00431
- NAID
 130007920176
- ISSN
 0009-2363, 1347-5223
- Year and Date
 2020-10-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-17K08385
[Journal Article] Copper‐Catalyzed Enantioselective Synthesis of Oxazolines from Aminotriols via Asymmetric Desymmetrization2020
- Author(s)
  Yamamoto Kosuke、Tsuda Yutaro、Kuriyama Masami、Demizu Yosuke、Onomura Osamu
- Journal Title
  
  Chemistry An Asian Journal
  
  Volume: 15 Issue: 6 Pages: 840-846
- DOI
  10.1002/asia.201901742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05459, KAKENHI-PROJECT-19K16317, KAKENHI-PROJECT-17K08385
[Journal Article] Development of Photoswitchable Estrogen Receptor Ligands2020
- Author(s)
  K. Tsuchiya, T. Umeno, G. Tsuji, H. Yokoo, M. Tanaka, K. Fukuhara, Y. Demizu, T. Misawa
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 68 Issue: 4 Pages: 398-402
- DOI
  10.1248/cpb.c19-01108
- NAID
  130007824936
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2020-04-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06588, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17K08385
[Journal Article] Design and Synthesis of 4-(2-Pyrrolyl)-4-phenylheptane Derivatives as Estrogen Receptor Antagonists2020
- Author(s)
  Tsuji Genichiro、Demizu Yosuke、Naganuma Miyako、Yokoo Hidetomo、Misawa Takashi、Matsuno Kenji
- Journal Title
  
  HETEROCYCLES
  
  Volume: 101 Issue: 2 Pages: 429-429
- DOI
  10.3987/com-19-14121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-17K08371
[Journal Article] An approach toward visual detection of single nucleotide polymorphism using pseudocomplementary peptide nucleic acid2020
- Author(s)
  Shun-suke Moriya, Yuko Sasa, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Atsushi Kittaka, and Toru Sugiyama
- Journal Title
  
  Peptide Science
  
  Volume: 2019 Pages: 173-174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06557
[Journal Article] Development of amphipathic antimicrobial peptide foldamers based on Magainin 2 sequence2019
- Author(s)
  C. Goto, M. Hirano, K. Hayashi, Y. Kikuchi, Y. Hara-Kudo, T. Misawa,* Y. Demizu*
- Journal Title
  
  ChemMedChem
  
  Volume: 14 Issue: 22 Pages: 1911-1916
- DOI
  10.1002/cmdc.201900460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502
[Journal Article] PNA Oligomers Possessing PreQ1 as a Cationic Analogue of Guanine2019
- Author(s)
  Toru Sugiyama, Hatsune Shibasaki, Shun-suke Moriya, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, and Atsushi Kittaka
- Journal Title
  
  Peptide Science
  
  Volume: 2018 Pages: 44-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06557
[Journal Article] Analysis of an Impurity, N-Nitrosodimethylamine, in Valsartan Drug Substances and Associated Products Using GC-MS2019
- Author(s)
 T. Tsutsumi, H. Akiyama,* Y. Demizu, N. Uchiyama, S. Masada, G. Tsuji, R. Arai, Y. Abe, Y. Haraya, T. Hakamatsuka, K. Izutsu, Y. Goda, H. Okuda
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 42 Issue: 4 Pages: 547-551
- DOI
 10.1248/bpb.b19-00006
- NAID
 130007622070
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2019-04-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-17K08385
[Journal Article] Rapid and efficient high-performance liquid chromatography analysis of N-nitrosodimethylamine impurity in valsartan drug substance and its medicines2019
- Author(s)
  S. Masada, G. Tsuji, R. Arai, N. Uchiyama,* Y. Demizu,* T. Tsutsumi, Y. Abe, H. Akiyama, T. Hakamatsuka, K. Izutsu, Y. Goda, H. Okuda
- Journal Title
  
  Sci. Rep.
  
  Volume: 9 Issue: 1 Pages: 11852-11852
- DOI
  10.1038/s41598-019-48344-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385
[Journal Article] Palladium-catalyzed synthesis of deuterated alkenes through deuterodechlorination of alkenyl chlorides2019
- Author(s)
  M. Kuriyama,* G. Yano, H. Kiba, T. Morimoto, K. Yamamoto, Y. Demizu, O. Onomura*
- Journal Title
  
  Org. Process Res. Dev.
  
  Volume: 23 Issue: 8 Pages: 1552-1557
- DOI
  10.1021/acs.oprd.9b00193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06582, KAKENHI-PROJECT-19K05459
[Journal Article] Inhibition of beta-amyloid-induced neurotoxicity by planar analogues of procyanidin B32019
- Author(s)
  M. Mizuno, K. Mori, T. Misawa, Y. Demizu, M. Shibanuma, K. Fukuhara*
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 29 Issue: 18 Pages: 2659-2663
- DOI
  10.1016/j.bmcl.2019.07.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06588, KAKENHI-PROJECT-19K07423
[Journal Article] Facile Synthesis of α-exo-Methylene Ketones from α,α-Disubstituted Allyl Alcohols 　by Electrochemical Oxidative Migration2019
- Author(s)
  Yamamoto, K.; Kikuchi, N.; Hamamizu, T.; Yoshimatsu, H.; Kuriyama, M.; Demizu, Y.; Onomura, O.
- Journal Title
  
  ChemElectroChem
  
  Volume: 印刷中 Issue: 16 Pages: 4169-4172
- DOI
  10.1002/celc.201900172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08167, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K05459
[Journal Article] Refining Calibration Procedures of Circular Dichroism Spectrometer to Improve Usability2019
- Author(s)
  K. Sakai-Kato,* K. Yoshida, T. Ohgita, Y. Takechi-Haraya, Y. Demizu, H. Saito
- Journal Title
  
  Anal. Sci.
  
  Volume: 35 Issue: 11 Pages: 1275-1278
- DOI
  10.2116/analsci.19N022
- NAID
  130007743081
- ISSN
  0910-6340, 1348-2246
- Year and Date
  2019-11-10
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-17H03979
[Journal Article] Development of small molecule chimeric degraders that bring target proteins and the aryl hydrocarbon receptor (AhR) E3 ligase into close proximity2019
- Author(s)
  N. Ohoka, G. Tsuji, T. Shoda, T. Fujisato, M. Kurihara, Y. Demizu, M. Naito*
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 14 Issue: 12 Pages: 2822-2832
- DOI
  10.1021/acschembio.9b00704
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16K08340
[Journal Article] Rational design of novel amphipathic antimicrobial peptides focused on the distribution of cationic amino acid residues2019
- Author(s)
  Misawa T, Goto C, Shibata N, Hirano M, Kikuchi Y, Naito M, Demizu Y
- Journal Title
  
  Med Chem Comm
  
  Volume: 印刷中 Issue: 6 Pages: 896-900
- DOI
  10.1039/c9md00166b
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17K08385
[Journal Article] Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating peptide foldamers for efficient siRNA delivery2019
- Author(s)
  T. Misawa,* N. Ohoka,* M. Oba, H. Yamashita, M. Tanaka, M. Naito, Y. Demizu*
- Journal Title
  
  Chem. Commun.
  
  Volume: 55 Issue: 54 Pages: 7792-7795
- DOI
  10.1039/c9cc02203a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14880, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502
[Journal Article] The extent of helical induction caused by introducing a-aminoisobutyric acid into an oligovaline sequence2018
- Author(s)
  G. Tsuji, T. Misawa, M. Doi, Y. Demizu*
- Journal Title
  
  ACS Omega
  
  Volume: 3 Issue: 6 Pages: 6395-6399
- DOI
  10.1021/acsomega.8b01030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14880
[Journal Article] Development of a small hybrid molecule that mediates degradation of His-tag fused proteins2018
- Author(s)
  K. Okitsu, T. Hattori, T. Misawa, T. Shoda, M. Kurihara, M. Naito, Y. Demizu
- Journal Title
  
  J Med Chem.
  
  Volume: 61 Issue: 2 Pages: 576-582
- DOI
  10.1021/acs.jmedchem.7b00413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-17K08385
[Journal Article] Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton2018
- Author(s)
  Eto Ryo、Misawa Takashi、Noguchi-Yachide Tomomi、Ohoka Nobumichi、Kurihara Masaaki、Naito Mikihiko、Tanaka Masakazu、Demizu Yosuke
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 26 Issue: 8 Pages: 1638-1642
- DOI
  10.1016/j.bmc.2018.02.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16J03592, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06570
[Journal Article] Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives2018
- Author(s)
  H. Kobayashi, T. Misawa,* M. Oba, N. Hirata, Y. Kanda, M. Tanaka, K. Matsuno, Y. Demizu*
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 66 Issue: 5 Pages: 575-580
- DOI
  10.1248/cpb.c18-00079
- NAID
  130006729546
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2018-05-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14880, KAKENHI-PROJECT-17H04107, KAKENHI-PROJECT-17K19503
[Journal Article] Design and synthesis of cell-permeable fluorescent nitrilotriacetic acid derivatives.2018
- Author(s)
  Tsuji G, Hattori T, Kato M, Hakamata W, Inoue H, Naito M, Kurihara M, Demizu Y, Shoda T.
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 26 Issue: 20 Pages: 5494-5498
- DOI
  10.1016/j.bmc.2018.09.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385
[Journal Article] Left-handed helix of three-membered ring amino acid homopeptide interrupted by an N-H...ethereal O type hydrogen bond2018
- Author(s)
  Y. Koba, A. Ueda, M. Oba, M. Doi, T. Kato, Y. Demizu, M. Tanaka*
- Journal Title
  
  Org. Lett.
  
  Volume: 20 Issue: 24 Pages: 7830-7834
- DOI
  10.1021/acs.orglett.8b03331
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14870, KAKENHI-PROJECT-17H03998, KAKENHI-PROJECT-17H07269, KAKENHI-PROJECT-16K18847
[Journal Article] Structural development of non-secosteroidal vitamin D receptor (VDR) ligands without any asymmetric carbon.2018
- Author(s)
  Misawa T, Tsuji G, Takahashi T, Ochiai E, Takagi KI, Horie K, Kakuda S, Takimoto-Kamimura M, Kurihara M, Demizu Y.
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 26 Issue: 23-24 Pages: 6146-6152
- DOI
  10.1016/j.bmc.2018.11.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385
[Journal Article] Right-handed and left-handed helical structures with fourteen (R)-chiral centers2017
- Author(s)
  R. Eto, M. Oba, A. Ueda, T. Uku, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 23 Issue: 72 Pages: 18120-18124
- DOI
  10.1002/chem.201705306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16K18847, KAKENHI-PROJECT-17H03998, KAKENHI-PROJECT-16J03592, KAKENHI-PROJECT-26460169
[Journal Article] PNA monomers fully compatible with standard Fmoc-based solid-phase synthesis of pseudocomplementary PNA2017
- Author(s)
  Toru Sugiyama, Genki Hasegawa, Chie Niikura, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, and Atsushi Kittaka
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 27 (15) Issue: 15 Pages: 3337-3341
- DOI
  10.1016/j.bmcl.2017.06.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169
[Journal Article] Rational design and synthesis of post-functionalizable peptide foldamers as helical templates2017
- Author(s)
  T. Misawa,* Y. Kanda, Y. Demizu*
- Journal Title
  
  Bioconj. Chem.
  
  Volume: 28 Issue: 12 Pages: 3029-3035
- DOI
  10.1021/acs.bioconjchem.7b00621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-17K19503, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-17H04107, KAKENHI-PROJECT-26460169
[Journal Article] Development of an ON/OFF switchable fluorescent probe targeting His tag fused proteins in living cells2017
- Author(s)
  Okitsu K, Misawa T, Shoda T, Kurihara M, Demizu Y.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 27 Issue: 15 Pages: 3417-3422
- DOI
  10.1016/j.bmcl.2017.05.087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169
[Journal Article] Low pH-responsive change in side chain structure of an amino acid from cyclic acetal to acyclic diol leads to conformational change in a peptide from a helical to random structure2017
- Author(s)
  K. Furukawa, M. Oba,* K. Toyama, G. O. Opiyo, Y. Demizu, M. Kurihara, M. Doi, M. Tanaka*
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 15 Issue: 30 Pages: 6302-6305
- DOI
  10.1039/c7ob01374d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-17H03998, KAKENHI-PROJECT-17J03086, KAKENHI-PROJECT-26460169
[Journal Article] Simple and efficient knockdown of His-tagged proteins by ternary molecules consist of His-tag ligand, ubiquitin ligase ligand and cell penetrating peptide2017
- Author(s)
  T. Hattori, K. Okitsu, N. Yamazaki, N. Ohoka, N. Shibata, T. Misawa, M. Kurihara, Y. Demizu,* M. Naito*
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 27 Issue: 18 Pages: 4478-4481
- DOI
  10.1016/j.bmcl.2017.08.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
[Journal Article] Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters.2017
- Author(s)
  Yamashita H, Misawa T, Oba M, Tanaka M, Naito M, Kurihara M, Demizu Y.
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 25(6) Issue: 6 Pages: 1846-1851
- DOI
  10.1016/j.bmc.2017.01.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26290055, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
[Journal Article] Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic2017
- Author(s)
  takashi misawa, katsuya tanaka, yosuke demizu, masaaki kurihara
- Journal Title
  
  bioorganic medicinal chemistry letter
  
  Volume: 印刷中 Issue: 11 Pages: 2590-2593
- DOI
  10.1016/j.bmcl.2017.03.066
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169
[Journal Article] Preorganized cyclic alpha,alpha-disubstituted alpha-amino acids bearing functionalized side chains that act as peptide-helix inducers2017
- Author(s)
  H. Kobayashi, T. Misawa, K. Matsuno, Y. Demizu*
- Journal Title
  
  J. Org. Chem.
  
  Volume: 82 Issue: 19 Pages: 10722-10726
- DOI
  10.1021/acs.joc.7b01946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169
[Journal Article] Design and synthesis of novel selective estrogen receptor degradation inducers based on diphenylheptane skeleton2017
- Author(s)
  T. Misawa, T. Fujisato, Y. Kanda, N. Ohoka, T. Shoda, M. Yorioka, M. Makishima, Y. Sekino, M. Naito, Y. Demizu, Masaaki Kurihara
- Journal Title
  
  MedChemComm
  
  Volume: 8 Issue: 1 Pages: 239-246
- DOI
  10.1039/c6md00553e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-26460169
[Journal Article] Tamoxifen and fulvestrant hybrid showed potency as a selective estrogen receptor down-regulator2017
- Author(s)
  Takuji Shoda, Masashi Kato, Takuma Fujisato, Yosuke Demizu, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara
- Journal Title
  
  Med. Chem.
  
  Volume: 13 Issue: 3 Pages: 206-213
- DOI
  10.2174/1573406412666160805101408
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169
[Journal Article] Helical L-Leu-based peptides having chiral five-membered carbocyclic ring amino acids with an ethylene acetal moiety2017
- Author(s)
  Y. Koba, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
- Journal Title
  
  ChemistrySelect
  
  Volume: 2 Issue: 26 Pages: 8108-8114
- DOI
  10.1002/slct.201700832
- NAID
  120006988059
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16K18847, KAKENHI-PROJECT-17H03998, KAKENHI-PROJECT-26460169
[Journal Article] Development of a peptide-based inducer of protein degradation targeting NOTCH12017
- Author(s)
  Ohoka N, Misawa T, Kurihara M, Demizu Y, Naito M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 27 Issue: 22 Pages: 4985-4988
- DOI
  10.1016/j.bmcl.2017.10.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
[Journal Article] Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules.2017
- Author(s)
  Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
- Journal Title
  
  Mol pharmacol
  
  Volume: 91 Issue: 3 Pages: 159-166
- DOI
  10.1124/mol.116.105569
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17H03979
[Journal Article] Development of helix-stabilized antimicrobial peptides composed of lysine and hydrophobic alpha,alpha-disubstituted alpha-amino acid residues2017
- Author(s)
  T. Misawa, M. Imamura, Y. Ozawa, K. Haishima, M. Kurihara, Y. Kikuchi,* Y. Demizu*
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 27 Issue: 17 Pages: 3950-3953
- DOI
  10.1016/j.bmcl.2017.07.074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-26460169
[Journal Article] Peptide Nucleic Acid with a Lysine Side Chain at the β-Position: Synthesis and Application for DNA Cleavage2016
- Author(s)
  Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 64 Issue: 7 Pages: 817-823
- DOI
  10.1248/cpb.c16-00191
- NAID
  130005160035
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15H04349, KAKENHI-PROJECT-26650033
[Journal Article] alpha-Helical structures of oligopeptides with alternating L-Leu-Aib segment2016
- Author(s)
  Y. Demizu,* K. Okitsu, H. Yamashita, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*
- Journal Title
  
  Eur. J. Org. Chem.
  
  Volume: XX Issue: 16 Pages: 2815-2820
- DOI
  10.1002/ejoc.201600327
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460169
[Journal Article] Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator.2016
- Author(s)
  Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T.
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 213 Issue: 8 Pages: 1441-1458
- DOI
  10.1084/jem.20151780
- NAID
  120006532434
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01150, KAKENHI-PUBLICLY-15H01176, KAKENHI-ORGANIZER-15H05935, KAKENHI-PUBLICLY-16H01631, KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06496, KAKENHI-PLANNED-16H06575, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-16H05342, KAKENHI-PROJECT-26460169, KAKENHI-INTERNATIONAL-16K21731, KAKENHI-PROJECT-16H06276
[Journal Article] Synthesis of chiral five-membered carbocyclic ring amino acids with an acetal moiety and helical conformations of its homo-chiral homopeptide2016
- Author(s)
  Y. Koba, Y. Hirata, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka
- Journal Title
  
  Biopolymers (Pept.Sci.)
  
  Volume: 印刷中 Issue: 4 Pages: 555-562
- DOI
  10.1002/bip.22769
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26105745, KAKENHI-PROJECT-26460169
[Journal Article] Induction of proteasomal degradation of ERα and subsequent cell death in breast cancer cells2016
- Author(s)
  K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 1366 Pages: 549-560
- DOI
  10.1007/978-1-4939-3127-9_42
- ISBN
  9781493931262, 9781493931279
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-16H05090
[Journal Article] Handedness preferences of heterochiral helical peptides containing homochiral peptide segments2016
- Author(s)
  Y. Demizu,* H. Yamashita, T. Misawa, M. Doi, M. Oba, M. Tanaka, M. Kurihara*
- Journal Title
  
  Eur. J. Org. Chem.
  
  Volume: 4 Issue: 4 Pages: 840-846
- DOI
  10.1002/ejoc.201501146
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460169
[Journal Article] Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids2016
- Author(s)
  T. Kato, H. Yamashita, T. Misawa, K. Nishida, M. Kurihara, M. Tanaka, Y. Demizu, M. Oba
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 24 Issue: 12 Pages: 2681-2687
- DOI
  10.1016/j.bmc.2016.04.031
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J05945, KAKENHI-PROJECT-25713008, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169
[Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.2016
- Author(s)
  Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 26 Issue: 20 Pages: 4865-4869
- DOI
  10.1016/j.bmcl.2016.09.041
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916
[Journal Article] A Helix-Stabilized Cell-Penetrating Peptide As An Intracellular-Delivery Tool2016
- Author(s)
  Hiroko Yamashita, Makoto Oba, Takashi Misawa, Masakazu Tanaka, Takayuki Hattori, Mikihiko Naito, Masaaki Kurihara, Yosuke Demizu
- Journal Title
  
  Chembiochem
  
  Volume: 17 Issue: 2 Pages: 137-140
- DOI
  10.1002/cbic.201500468
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08040, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905
[Journal Article] Helical structures of homo-chiral isotope-labeled alpha-aminoisobutyric acid peptides2016
- Author(s)
  A. Ueda, M. Oba, Y. Izumi, Y. Sueyoshi, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
- Journal Title
  
  Tetrahedron
  
  Volume: 39 Issue: 39 Pages: 5864-5871
- DOI
  10.1016/j.tet.2016.08.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K18847
[Journal Article] Development of a peptide-based inducer of nuclear receptors degradation.2016
- Author(s)
  Demizu Y, Ohoka N, Nagakubo T, Yamashita H, Misawa T, Okuhira K, Naito M, Kurihara M.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 26 Issue: 11 Pages: 2655-2658
- DOI
  10.1016/j.bmcl.2016.04.013
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
[Journal Article] Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment2016
- Author(s)
  H. Yamashita, T. Kato, M. Oba, T. Misawa, T. Hattori, N. Ohoka, M. Tanaka, M. Naito, M. Kurihara, Y. Demizu
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 33003-33003
- DOI
  10.1038/srep33003
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15J05945, KAKENHI-PROJECT-25713008, KAKENHI-PROJECT-26460169
[Journal Article] Influence of L-Leu to D-Leu replacement on the helical secondary structures of L-Leu-Aib-based dodecapeptides2016
- Author(s)
  Y. Demizu,* K. Okitsu, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*
- Journal Title
  
  ChemistrySelect
  
  Volume: 1 Issue: 18 Pages: 5805-5811
- DOI
  10.1002/slct.201601493
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460169
[Journal Article] Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator2016
- Author(s)
  Takuji Shoda, Masashi Kato, Takuma Fujisato, Takashi Misawa, Yosuke Demizu, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 24 Issue: 13 Pages: 2914-2919
- DOI
  10.1016/j.bmc.2016.04.068
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K18916
[Journal Article] The side-chain hydroxy groups of a cyclic alpha,alpha-disubstituted alpha-amino acid promote oligopeptide helix packing in the crystalline state2016
- Author(s)
  Y. Demizu,* M. Doi, H. Yamashita, T. Misawa, M. Oba, M. Kurihara, H. Suemune, M. Tanaka
- Journal Title
  
  Biopolymers (Pept. Sci.)
  
  Volume: 106 Issue: 5 Pages: 757-768
- DOI
  10.1002/bip.22881
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460169
[Journal Article] A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N-OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products2015
- Author(s)
  N. Uchiyama,* Y. Shimokawa, R. Kikura-Hanajiri, Y. Demizu, Y. Goda, T. Hakamatsuka
- Journal Title
  
  Forensic Toxicol.
  
  Volume: 33 Issue: 2 Pages: 244-259
- DOI
  10.1007/s11419-015-0268-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460169
[Journal Article] Synthesis and Evaluation of Novel Carbocyclic Oxetanocin A (COA-Cl) Derivatives as Potential Tube Formation Agents2015
- Author(s)
  N. Sakakibara,* J. Igarashi, M. Takata, Y. Demizu, T. Misawa, M. Kurihara, R. Konishi, Y. Kato, T. Maruyama, I. Tsukamoto
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 63 Issue: 9 Pages: 701-709
- DOI
  10.1248/cpb.c15-00386
- NAID
  130005096030
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-25461132
[Journal Article] Design, synthesis and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives2015
- Author(s)
  N. Sakakibara,* M. Baba, M. Okamoto, M. Toyama, Y. Demizu, T. Misawa, M. Kurihara, K. Irie, Y. Kato, T. Maruyama
- Journal Title
  
  Antiviral Chem. Chemother.
  
  Volume: 24 Issue: 1 Pages: 3-18
- DOI
  10.1177/2040206614566584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460169
[Journal Article] 短鎖ペプチドのヘリカル構造制御と機能化2015
- Author(s)
  出水庸介*，三澤隆史，栗原正明*
- Journal Title
  
  有機合成化学協会誌
  
  Volume: 72 Pages: 1336-1359
- NAID
  130004749130
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460169
[Journal Article] Synthesis of a bis-cationic α,α-disubstituted amino acid (9-amino-bispidine-9-carboxylic acid) and its effects on the conformational properties of peptides2015
- Author(s)
  H. Yamashita, Y. Demizu,* T. Misawa, T. Shoda, M. Kurihara*
- Journal Title
  
  Tetrahedron
  
  Volume: 71 Issue: 15 Pages: 2241-2245
- DOI
  10.1016/j.tet.2015.02.076
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
[Journal Article] Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators2015
- Author(s)
  T. Shoda,* M. Kato, T. Fujisato, K. Okuhira, Y. Demizu, H. Inoue, M. Naito, M. Kurihara*
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 13 Pages: 3091-3096
- DOI
  10.1016/j.bmc.2015.05.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-25430164
[Journal Article] Synthesis and resolution of substituted [5]carbohelicenes2015
- Author(s)
  K. Usui,* K. Yamamoto, T. Shimizu, M. Biao, M. Okazumi, Y. Demizu, M. Kurihara, H. Suemune*
- Journal Title
  
  J. Org. Chem.
  
  Volume: 80 Issue: 12 Pages: 6502-6508
- DOI
  10.1021/acs.joc.5b00759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-14J03777, KAKENHI-PROJECT-25410096
[Journal Article] Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides2015
- Author(s)
  M. Oba,* Y. Demizu, H. Yamashita, M. Kurihara, M. Tanaka
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Issue: 15 Pages: 4911-4918
- DOI
  10.1016/j.bmc.2015.05.025
- NAID
  120006986986
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-25713008
[Journal Article] Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton2015
- Author(s)
  Takashi Misawa, Momoko Yorioka, Yosuke Demizu, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Megumi Kurashima-Kinoshita, Hitomi Motoyoshi, Hisao Nojiri, Atsushi Kittaka, Makoto Makishima, Mikihiko Naito, Masaaki Kurihara
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Issue: 22 Pages: 5362-5366
- DOI
  10.1016/j.bmcl.2015.09.030
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-26860049
[Journal Article] Amino equatorial effect of a six-membered ring amino acid on its peptide 310- and a-helices2015
- Author(s)
  Takayuki Hirata, Atsushi Ueda, Makoto Oba, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Masanobu Nagano, Hiroshi Suemune, Masakazu Tanaka
- Journal Title
  
  Tetrahedron
  
  Volume: 71 Issue: 16 Pages: 2409-2420
- DOI
  10.1016/j.tet.2015.02.075
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J03534, KAKENHI-PROJECT-25410096, KAKENHI-PUBLICLY-26105745, KAKENHI-PROJECT-26460169
[Journal Article] A preorganized β-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides2015
- Author(s)
  Y. Demizu,* M. Oba, K. Okitsu, H. Yamashita, T. Misawa, M. Doi, M. Tanaka, M. Kurihara, S. H. Gellman
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 13 Issue: 20 Pages: 5617-5620
- DOI
  10.1039/c5ob00389j
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169
[Journal Article] Effects of D-Leu Residues on the Helical Secondary Structures of L-Leu-Based Nonapeptides2015
- Author(s)
  Y. Demizu,* H. Yamashita, T. Misawa, M. Doi, M. Tanaka, M. Kurihara*
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 63 Issue: 3 Pages: 218-224
- DOI
  10.1248/cpb.c14-00760
- NAID
  130004803775
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460169
[Journal Article] Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives2015
- Author(s)
  N. Sakakibara,* G. Balboni, C. Congiu, V. Onnis, Y. Demizu, T. Misawa, M. Kurihara, Y. Kato, T. Maruyama, M. Toyama, M. Okamoto, M. Baba
- Journal Title
  
  Antiviral Chem. Chemother.
  
  Volume: 24 Issue: 2 Pages: 62-71
- DOI
  10.1177/2040206615612208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460169
[Journal Article] Peptide foldamers composed of six-membered ring α,α-disubstituted α-amino acid with two changeable chiral acetal moieties2015
- Author(s)
  K. Tanda, R. Eto, K. Kato, M. Oba, A. Ueda, H. Suemune, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
- Journal Title
  
  Tetrahedron
  
  Volume: 71 Issue: 23 Pages: 3909-3914
- DOI
  10.1016/j.tet.2015.04.031
- NAID
  120006987063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PUBLICLY-26105745
[Journal Article] Topological study of the structures of heterochiral peptides with equal amounts of L-Leu and D-Leu2015
- Author(s)
  Y. Demizu,* H. Yamashita, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*
- Journal Title
  
  J. Org. Chem.
  
  Volume: 80 Issue: 17 Pages: 8597-8603
- DOI
  10.1021/acs.joc.5b01541
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905
[Journal Article] Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription2015
- Author(s)
  Y. Demizu*, T. Misawa, T. Nagakubo, Y. Kanda, K. Okuhira, Y. Sekino, M. Naito, M. Kurihara*
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 23 Issue: 15 Pages: 4132-4138
- DOI
  10.1016/j.bmc.2015.06.067
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26670041
[Journal Article] Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors.2015
- Author(s)
  T. Misawa, Y. Demizu, M. Kawamura, N. Yamagata, M. Kurihara.
- Journal Title
  
  Bioorganic medicinal chemistry
  
  Volume: 23 Issue: 5 Pages: 1055-1061
- DOI
  10.1016/j.bmc.2015.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25893038, KAKENHI-PROJECT-26460169
[Journal Article] 短鎖ペプチドのヘリカル構造制御と機能化2014
- Author(s)
  出水庸介*
- Journal Title
  
  ペプチドニュースレター
  
  Volume: 94 Pages: 3-7
- NAID
  130004749130
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460169
[Journal Article] Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator.2014
- Author(s)
  Shoda, T., Okuhira, K., Kato, M., Demizu, Y., Inoue, H., Naito, M., and Kurihara, M.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 24 Issue: 1 Pages: 87-89
- DOI
  10.1016/j.bmcl.2013.11.078
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
[Journal Article] NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells.2014
- Author(s)
  Yamada S, Kotake Y, Demizu Y, Kurihara M, Sekino Y, Kanda Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 4 Issue: 1 Pages: 5952-5952
- DOI
  10.1038/srep05952
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24406004, KAKENHI-PROJECT-26460169
[Journal Article] Conformational studies on peptides having chiral five-membered ring amino acid with two azido or triazole functional groups within the sequence of Aib residues2014
- Author(s)
  Makoto Oba, Naomi Kawabe, Hiroomi Takazaki, Yosuke Demizu, Mitsunobu Doi, Masaaki Kurihara, Hiroshi Suemune, Masakazu Tanaka
- Journal Title
  
  Tetrahedron
  
  Volume: 70 Issue: 46 Pages: 8900-8907
- DOI
  10.1016/j.tet.2014.09.086
- NAID
  120006987171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25410096, KAKENHI-PROJECT-25713008, KAKENHI-PUBLICLY-26105745, KAKENHI-PROJECT-26460169
[Journal Article] Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability2014
- Author(s)
  Hiroko Yamashita, Yosuke Demizu, Takuji Shoda, Yukiko Sato, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 22 Issue: 8 Pages: 2403-2408
- DOI
  10.1016/j.bmc.2014.03.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25713008, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
[Journal Article] Isoheleproline: a new amino acid-sesquiterpene adduct from Inula helenium2014
- Author(s)
  K. Zaima, D. Wakana, Y. Demizu, Y. Kumeta, H. Kamakura, T. Maruyama, M. Kurihara, Y. Goda*
- Journal Title
  
  J. Nat. Med.
  
  Volume: 68 Issue: 2 Pages: 432-435
- DOI
  10.1007/s11418-013-0806-8
- NAID
  40020023355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460169
[Journal Article] Helical Peptide-Foldamers Having a Chiral Five-Membered Ring Amino Acid with Two Azido Functional Groups2014
- Author(s)
  Makoto Oba, Hiroomi Takazaki, Naomi Kawabe, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Hiromu Kawakubo, Masanobu Nagano, Hiroshi Suemune, and Masakazu Tanaka
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 79 Issue: 19 Pages: 9125-9140
- DOI
  10.1021/jo501493x
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J03534, KAKENHI-PROJECT-25410096, KAKENHI-PROJECT-25713008, KAKENHI-PUBLICLY-26105745, KAKENHI-PROJECT-26460169
[Journal Article] Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription.2014
- Author(s)
  2.Nagakubo, T., Demizu, Y., Kanda, Y., Misawa, T., Shoda, T., Okuhira, K., Sekino., Y., Naito, M. and Kurihara, M
- Journal Title
  
  Bioconjug Chem.
  
  Volume: 25 Issue: 11 Pages: 1921-24
- DOI
  10.1021/bc500480e
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
[Journal Article] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.2013
- Author(s)
  Okuhira, K., Demizu, Y., Hattori, T., Ohoka, N., Shibata, N., Nishimaki-Mogami, T., Okuda, H., Kurihara, M., Natiro, M.
- Journal Title
  
  Cancer Science
  
  Volume: 104 Issue: 11 Pages: 1492-1498
- DOI
  10.1111/cas.12272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790117, KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084
[Journal Article]2013
- Author(s)
  Y. Demizu, S. Nagoya, M. Shirakawa, M. Kawamura, N. Yamagata, Y. Sato, M. Doi, M. Kurihara
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 23
- URL
  http://www.sciencedirect.com/science/article/pii/S0960894X13007099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] One-Handed Helical Screw Direction of Homopeptide Foldamer Exclusively Induced by Cyclic α-Amino Acid Side-Chain Chiral Centers2012
- Author(s)
  Y.Demizu
- Journal Title
  
  Chem.Eur.J.
  
  Volume: 18 Pages: 2430-2439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012
- Author(s)
  Y.Demizu
- Journal Title
  
  Bioorg.Med.Chem.Lett
  
  Volume: 22 Pages: 1793-1796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Twisted Structure of a Cyclic Hexapeptide Containing a Combination of Alternating L-Leu-D-Leu- Aib Segments2012
- Author(s)
  Demizu, Y., Nagoya, S., Doi, M., Sato, Y., Tanaka, M., Kurihara, M
- Journal Title
  
  J. Org. Chem
  
  Volume: 77 Pages: 9361-9365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Conformations of helical Aib peptides containinga pair of L-amino acid and D-amino acid2012
- Author(s)
  Y. Demizu, Y. Yabuki, M. Doi, Y. Sato,M. Tanaka, M. Kurihara
- Journal Title
  
  J. Pept. Sci
  
  Volume: 18 Issue: 7 Pages: 466-475
- DOI
  10.1002/psc.2418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Solid-phase nucleophilic fluorination2012
- Author(s)
  Y. Demizu
- Journal Title
  
  Synth. Commun.
  
  Volume: 42 Pages: 1724-1730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012
- Author(s)
  Y. Demizu, K. Okuhira, H. Motoi, A. Ohno, T. Shoda, K. Fukuhara, H. Okuda, M. Naito, M. Kurihara
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 22 Pages: 1793-1796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Identification of Mutaprodenafil in a Dietary Supplement and its Subsequent Synthesis2011
- Author(s)
  Y.Demizu
- Journal Title
  
  Chem.Pharm.Bull.
  
  Volume: 59 Pages: 1314-1316
- NAID
  130001087104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Facile synthesis of stereoisomers of the non-secosteroidal ligand LG190178 and their evaluation using the mutant vitamin D receptor2011
- Author(s)
  Demizu, Y.
- Journal Title
  
  Lett.Org.Chem
  
  Volume: 8 Pages: 43-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Effect of one D-Leu residue on right-handed helical-L-Leu-Aib-peptides in the crystal state2011
- Author(s)
  Y.Demizu
- Journal Title
  
  J.Pept.Sci.
  
  Volume: 17 Pages: 420-426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Facile synthesis of stereoisomers of the non-secosteroidal ligand LG190178 and their evaluation using the mutant vitamin D receptor2011
- Author(s)
  Y.Demizu, et al.
- Journal Title
  
  Lett.Org.Chem.
  
  Volume: 8 Pages: 43-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Effect of one D-Leu residue on right-handed helical -L-Leu-Aibpeptides in the crystal state2011
- Author(s)
  Y. Demizu, M. Doi, Y. Sato, M. Tanaka, H. Okuda, M. Kurihara
- Journal Title
  
  J. Pept. Sci
  
  Volume: 17 Pages: 420-426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Effect of one D-Leu residue on right-handed helical -L-Leu-Aib- peptides in the crystal state2011
- Author(s)
  Y.Demizu, et al.
- Journal Title
  
  J.Pept.Sci.
  
  Volume: 17 Pages: 420-426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Enantioselective epoxidation of α,β-unsaturated ketones catalyzed by stapled helical L-Leu-based peptides2011
- Author(s)
  Y. Demizu, N. Yamagata, S. Nagoya, Y. Sato, M. Doi, M. Tanaka, K. Nagasawa, H. Okuda, M. Kurihara
- Journal Title
  
  Tetrahedron
  
  Volume: 67 Pages: 6155-6165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Design of a stabilized short helical peptide and its application to catalytic enantioselective epoxidation of (E)-chalcone2011
- Author(s)
  Yamagata, N., Demizu, Y., Sato, Y., Doi, M., Tanaka, M., Nagasawa, K., Okuda, H., Kurihara, M
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 52 Pages: 798-801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Conformational studies on peptides containing α,α-disubstituted α-amino acids : chiral cyclic α,α-disubstituted α-amino, acid as an α-helical inducer2011
- Author(s)
  Y.Demizu, et al.
- Journal Title
  
  Org.Biomol.Chem.
  
  Volume: 9 Pages: 3303-3312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Design of a stabilized short helical peptide and its application to catalytic enantioselective epoxidation of (E)-chalcone2011
- Author(s)
  N.Yamagata, Y.Demizu, Y.Sato, M.Doi, M.Tanaka, K.Nagasawa, H.Okuda, M.Kurihara
- Journal Title
  
  Tetrahedron Lett. 52
  
  Pages: 798-801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Screw-Sense Control of Helical Oligopeptides Containing Equal Amounts of l- and d-Amino Acids2011
- Author(s)
  Y. Demizu, M. Doi, M. Tanaka, H. Okuda, M. Kurihara
- Journal Title
  
  Chem. Eur. J.,
  
  Volume: 17 Pages: 11107-11109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Conformational studies on peptides containing α,α-disubstituted α-amino acids : chiral cyclic α,α-dsubstituted α-amino acid as an α-helical inducer2011
- Author(s)
  Y.Demizu
- Journal Title
  
  Org.Biomol.Chem.
  
  Volume: 9 Pages: 3303-3312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands2011
- Author(s)
  Y.Demizu
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume: 21 Pages: 6104-6107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Facile synthesis of stereoisomers of the non-secosteroidal ligand LG190178 and their evaluation using the mutant vitamin D receptor2011
- Author(s)
  Y.Demizu
- Journal Title
  
  Lett.Org.Chem.
  
  Volume: 8 Pages: 43-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Three-Dimensional Structural Control of Diastereomeric Leu-Leu-Aib-Leu-Leu-Aib Sequences in the Solid State2010
- Author(s)
  Demizu, Y.
- Journal Title
  
  J Org.Chem.
  
  Volume: 75 Pages: 5234-5239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Conformational analysis of water-soluble oligopeptide composed of chiral cyclic α, α-disubstituted α-amino acids2010
- Author(s)
  Y.Demizu
- Journal Title
  
  Peptide Science 2009
  
  Pages: 381-382
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Controlling the helical screw sense of peptides by N-terminal proline2010
- Author(s)
  N.Yamagata, Y.Demizu, Y.Sato, M.Oba, M.Tanaka, M.Doi, K.Nagasawa, H.Suemune, H.Okuda, M.Kurihara
- Journal Title
  
  Peptide Science 2009
  
  Pages: 383-384
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Three-dimensional structure control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences in the solid state2010
- Author(s)
  Y.Demizu, et al.
- Journal Title
  
  J.Org.Chem.
  
  Volume: 75 Pages: 5234-5239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Conformational analysis of water-soluble oligopeptides composed of chiral cyclicα,α-disubstitutedα,-amino acids2010
- Author(s)
  Y.Demizu, M.Tanaka, H.Suemune, M.Doi, Y.Sato, H.Okuda, M.Kurihara
- Journal Title
  
  Peptide Science 2009
  
  Pages: 381-382
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Conformations of peptides containing a chiral cyclic α,α-disubstituted α-amino acid within the sequence of Aib residues2010
- Author(s)
  Y.Demizu, et al.
- Journal Title
  
  J.Pept.Sci.
  
  Volume: 16 Pages: 621-626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Controlling the helical screw sense of peptides with C-terminal L-valine2010
- Author(s)
  Y.Demizu, et al.
- Journal Title
  
  J.Pept.Sci. 16
  
  Pages: 153-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Three-dimensional structure control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences in the solid state2010
- Author(s)
  Y.Demizu, M.Doi, Y.Sato, M.Tanaka, H.Okuda, M.Kurihara
- Journal Title
  
  J.Org.Chem. 75
  
  Pages: 5234-5239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Three-Dimensional Structural Control of Diastereomeric Leu-Leu-Aib-Leu-Leu-Aib Sequences in the Solid State2010
- Author(s)
  Demizu, Y., Doi, M., Sato, Y., Tanaka, M., Okuda, H., Kurihara, M
- Journal Title
  
  J. Org. Chem
  
  Volume: 75 Pages: 5234-5239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Controlling the helical screw sense of peptides with C-terminal L-valine2010
- Author(s)
  Demizu, Y., Yamagata, N., Sato, Y., Doi, M., Tanaka, M., Okuda, H., Kurihara, M
- Journal Title
  
  J. Pept. Sci.
  
  Volume: 16 Pages: 153-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Computational study on helical structure of chiralα,α-disubstituted oligopeptides2010
- Author(s)
  M.Kurihara, Y.Sato, N.Yamagata, Y.Demizu, H.Okuda, M.Nagano, M.Doi, M.Tanaka, H.Suemune
- Journal Title
  
  Peptide Science 2009
  
  Pages: 385-386
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Conformations of peptides containing a chiral cyclic-α,α-disubstituted α-amino acid within the sequence of Aib residues2010
- Author(s)
  Y.Demizu, M.Tanaka, M.Doi, M.Kurihara, H.Okuda, H.Suemune
- Journal Title
  
  J.Pept.Sci. 16
  
  Pages: 621-626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Controlling the helical screw sense of peptides with C-terminal L-valine2010
- Author(s)
  Demizu, Y.
- Journal Title
  
  J.Pent. Sci.
  
  Volume: 16 Pages: 153-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Conformations of peptides containing a chiral cyclic α, α-disubstituted α-amino acid within the sequence of Aib residues2010
- Author(s)
  Demizu, Y.
- Journal Title
  
  J.Pept.Sci.
  
  Volume: 16 Pages: 621-626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590114
[Journal Article] Facile synthesis of optically active oxindoles by copper-catalyzed asymmetric monotosylation of prochiral 1,3-diols2010
- Author(s)
  M.Kuriyama, S.Tanigawa, Y.Kubo, Y.Demizu, O.Onomura
- Journal Title
  
  Tetrahedron : Asymmetry 21
  
  Pages: 1370-1373
- NAID
  120006984560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Controlling the helical screw sense of peptides with C-terminal L-valine2010
- Author(s)
  Y.Demizu, N.Yamagata, Y.Sato, M.Doi, M.Tanaka, H.Okuda, M.Kurihara
- Journal Title
  
  J.Pept.Sci. 16
  
  Pages: 153-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Solid-state conformation of diastereomeric -Pro-Pro-(Aib)_4 sequences2010
- Author(s)
  M.Oba, Y.Demizu, N.Yamagata, Y.Sato, M.Doi, M.Tanaka, H.Suemune, H.Okuda, M.Kurihara
- Journal Title
  
  Tetrahedron 66
  
  Pages: 2293-2296
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Helical-screw directions of diastereoisomeric cyclic α-amino acid oligomers2009
- Author(s)
  M.Nagano, M.Tanaka, M.Doi, Y.Demizu, M.Kurihara, H.Suemune
- Journal Title
  
  Org.Lett. 11
  
  Pages: 1135-1137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Ring contraction of α,β-unsaturated cyclic amines with cis-dihydroxylation at the α,β-position,S.2009
- Author(s)
  S.Libendi, Y.Demizu, Y.Matsumura, O.Onomura
- Journal Title
  
  Heterocycles 77
  
  Pages: 311-321
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Non-enzymatic kinetic resolut with chiral conner catalvstion of racemic α-hydroxyalkanephosphonates2009
- Author(s)
  Y.Demizu, et al.
- Journal Title
  
  Tetrahedron Lett. 37
  
  Pages: 5241-5244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Direct electrochemical α-cyanation of N-protected cyclic amines, S. S. Libendi2009
- Author(s)
  Y.Demizu, O.Onomura
- Journal Title
  
  Org.Biomol.Chem. 7
  
  Pages: 351-356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Computational study on helical structure of α,α-disubstituted oligopeptides containing chiral α-amino acids2009
- Author(s)
  M.Kurihara, Y.Sato, N.Yamagata, H.Okuda, M.Nagano, Y.Demizu, M.Doi, M.Tanaka, H.Suemune
- Journal Title
  
  Peptide Science 2008
  
  Pages: 149-150
- NAID
  10027166112
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Non-enzymatic kinetic resolution of racemic alpha-hydroxyalkanephosphonates with chiral copper catalyst2009
- Author(s)
 Y.Demizu, A.Moriyama, O.Onomura
- Journal Title
 
 Tetrahedron Lett.<Highlighted by Synfacts 1126 (2009)> 37
 
 Pages: 5241-5244
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-21790018
[Journal Article] Non-enzymatic kinetic resolution of 3-hydroxyalkanamides with chiral copper catalyst2008
- Author(s)
  Y. Demizu, Y. Kubo, Y. Matsumura, O. Onomura
- Journal Title
  
  Synlett
  
  Pages: 433-437
- NAID
  120006982422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Convenient synthesis of enantiomerically enriched bicyclic proline and the corresponding N-oxyls2008
- Author(s)
  Demizu, Y. et al.
- Journal Title
  
  Tetrahedron : Asymmetry 19
  
  Pages: 2659-2665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Non-enzymatic kinetic resolution of 3-hydroxyalkanamides with chiral copper catalyst2008
- Author(s)
  Demizu, Y., et. al.
- Journal Title
  
  Synlett 3
  
  Pages: 433-437
- NAID
  120006982422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Oxidative C-C bond cleavage of N-alkoxycarbonylated cyclic amines by sodium nitrite in trifluoroacetic acid2008
- Author(s)
  O. Onomura, A. Moriyama, K. Fukae, Y. Yamamoto, T. Maki, Y. Matsumura, Y. Demizu
- Journal Title
  
  Tetrahedron Lett 49
  
  Pages: 6728-6731
- NAID
  120006982372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Asymmetric electrochemical oxidation of 1,2-diols, aminoalcohols and aminoaldehydes in the presenceof chiral copper catalyst2008
- Author(s)
  D. Minato, H. Arimoto, Y. Nagasue, Y. Demizu, O. Onomura
- Journal Title
  
  Tetrahedron 64
  
  Pages: 6675-6683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Regioselective protection of sugars catalyzed by dimethyltin dichloride2008
- Author(s)
  Y. Demizu, Y. Kubo, H. Miyoshi, T. Maki, Y. Matsumura, N. Moriyama, O. Onomura
- Journal Title
  
  Org. Lett 10
  
  Pages: 5075-5077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Diastereoselective arylation of L-proline derivatives at the 5-position2008
- Author(s)
  O. Onomura, P. G. Kirira, T. Tanaka, S. Tsukada, Y. Matsumura, Y. Demizu
- Journal Title
  
  Tetrahedron 64
  
  Pages: 7498-7503
- NAID
  120006981712
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Convenient synthesis of enantiomerically enriched bicyclic proline and the corresponding N-oxyls2008
- Author(s)
  Y. Demizu, H. Shiigi, H. Mori, K. Matsumoto, O. Onomura
- Journal Title
  
  Tetrahedron: Asymmetry 19
  
  Pages: 2659-2665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Regioselective introduction of electrophiles into piperidine derivatives at the 4-position2008
- Author(s)
  O. Onomura, N. Fujimura, T. Oda, Y. Matsumura, Y. Demizu
- Journal Title
  
  Heterocycles 76
  
  Pages: 177-182
- NAID
  120006984129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Chiral azabicyclo-N-oxyls mediated enantioselective electrooxidation of sec-alcohols2008
- Author(s)
  H. Shiigi, H.Mori, T. Tanaka, Y. Demizu, O. Onomura
- Journal Title
  
  Tetrahedron Lett 49
  
  Pages: 5247-5251
- NAID
  120006981658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Non-enzymatic kinetic resolution of 3-hydroxyalkanamides with chiral copper catalyst2008
- Author(s)
  Demizu, Y. et al.
- Journal Title
  
  Synlett
  
  Pages: 433-437
- NAID
  120006982422
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Effecient kinetic resolution of racemic-aminoaldehydes by oxidation with NIS2008
- Author(s)
  D. Minato, Y. Nagasue, Y. Demizu, O. Onomura
- Journal Title
  
  Angew. Chem. Int. Ed 47
  
  Pages: 9458-9461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Regioselective protection of sugars catalyzed by dimethyltin dichloride2008
- Author(s)
  Demizu, Y. et al.
- Journal Title
  
  Organic Letters 10
  
  Pages: 5075-5077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Computational study on secondary structure of oligopeptides containing α,α-disubstituted α-amino acids2008
- Author(s)
  M. Kurihara, Y. Sato, F. Kaneko, H. Okuda, M. Nagano, Y. Demizu, M. Doi, M. Tanaka, H. Suemune
- Journal Title
  
  Peptide Science 2007
  
  Pages: 137-138
- NAID
  10021906747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls2008
- Author(s)
  Demizu, Y. et al.
- Journal Title
  
  Tetrahedron Letters 49
  
  Pages: 48-52
- NAID
  120006981360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls2008
- Author(s)
  Demizu, Y., et. al.
- Journal Title
  
  Tetrahedron Letters 49
  
  Pages: 48-52
- NAID
  120006981360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] High regioselective in electrochemical α-methoxylation of N-protected cyclic amines2008
- Author(s)
  S. S. Libendi, Y. Demizu, Y. Matsumura, O. Onomura
- Journal Title
  
  Tetrahedron 64
  
  Pages: 3935-3942
- NAID
  120006981389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls2008
- Author(s)
  Y. Demizu, H. Shiigi, T. Oda, Y. Matsumura, O. Onomura
- Journal Title
  
  Tetrahedron Lett 49
  
  Pages: 48-52
- NAID
  120006981360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Lipase-catalyzed kinetic resolution of cyclic trans-1,2-diols bearing a diester moiety: Synthetic application to chiral seven-membered ring α,α-disubstituted α-amino acid2007
- Author(s)
  M. Tanaka, Y. Demizu, M. Nagano, M. Hama, Y. Yoshida, M. Kurihara, H. Suemune
- Journal Title
  
  J. Org. Chem 72
  
  Pages: 7750-7756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCM2007
- Author(s)
  T. Maruyama, Y. Demizu, S. Kozai, M. Witvrouw, C. Pannecouque, P. J. Balzarini, R. Snoecks, G. Andrei, E. De Clercq
- Journal Title
  
  Nucleosides, Nucleotides & Nucleic Acids 26
  
  Pages: 1553-1558
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] 1,2-ジオール分子認識に基づく選択的分子変換反応2007
- Author(s)
  松村功啓、尾野村治、出水庸介
- Journal Title
  
  有機合成化学協会誌第65巻
  
  Pages: 46-55
- NAID
  10018578272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Controlling 310-helix and α-helix of short peptides in the solid state2007
- Author(s)
  Y. Demizu, M. Tanaka, M. Nagano, M. Kurihara, M. Doi, T. Maruyama, H. Suemune
- Journal Title
  
  Chem. Pharm. Bull 55
  
  Pages: 840-842
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Controlling 3_<10>-helix and α-helix of short peptides in the solid state2007
- Author(s)
 Y.Demizu, M.Tanaka, M.Nagano, M.Kurihara, M.Doi, T.Maruyama, H.Suemune
- Journal Title
 
 Chemical ＆ Pharmaceutical Bulletin. (in press)
- NAID
 110006273081
- Data Source
 KAKENHI-PROJECT-17790028
[Journal Article] Asymmetric tosylation of racemic 2-hydroxyalkanamides with chiral copper catalyst2007
- Author(s)
  O. Onomura, M. Mitsuda, T. T. M. Nguyen, Y. Demizu
- Journal Title
  
  Tetrahedron Lett 48
  
  Pages: 9080-9084
- NAID
  120006981361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Copper complex catalyzed asymmetric monosulfonylation of meso-vic-diols2007
- Author(s)
  Y. Demizu, K. Matsumoto, O. Onomura, Y. Matsumura
- Journal Title
  
  Tetrahedron Lett 48
  
  Pages: 7605-7609
- NAID
  120006981364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Computational study on conformation of oligopeptides containing chiral cyclic α,α-disubstituted a-amino acids2007
- Author(s)
  M. Kurihara, Y. Sato, W. Hakamata, H. Okuda, Y. Demizu, M. Nagano, N. Kawabe, M. Doi, M. Tanaka, H. Suemune
- Journal Title
  
  Peptides 2006
  
  Pages: 546-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Secondary structure of heteropeptides using chiral cyclic α,α-disubstituted amino acids2007
- Author(s)
  M. Nagano, M. Tanaka, Y. Demizu, M. Kurihara, M. Doi, H. Suemune
- Journal Title
  
  Peptides 2006
  
  Pages: 476-477
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Side-chain chiral centers of amino acids and helical-screw handedness of their peptides2007
- Author(s)
  M. Tanaka, M. Nagano, Y. Demizu, K. Anan, M. Kurihara, M. Doi, H. Suemune
- Journal Title
  
  Peptides 2006
  
  Pages: 268-269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Asymmetric oxidation of 1,2-diols using N-bromosuccinimide in the presence of chiral copper catalyst2007
- Author(s)
  O. Onomura, H. Arimoto, Y. Matsumura, Y. Demizu
- Journal Title
  
  Tetrahedron Lett 48
  
  Pages: 8668-8672
- NAID
  120006981362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790017
[Journal Article] Kinetic resolution of vic-amino alcohols catalyzed by a chiral Cu(II) complex2006
- Author(s)
  M.Mitsuda, T.Tanaka, T.Tanaka, Y.Demizu, O.Onomura, Y.Matsumura
- Journal Title
  
  Tetrahedron Letters 47(46)
  
  Pages: 8073-8073
- NAID
  120006981365
- Data Source
  KAKENHI-PROJECT-17790028
[Journal Article] Asymmetric desymmetrization of meso-vic-diols by carbamoylation catalyzed with chiral Cu(II) complex2006
- Author(s)
  K.Matsumoto, M.Mitsuda, N.Ushijima, Y.Demizu, O.Onomura, Y.Matsumura
- Journal Title
  
  Tetrahedron Letters 47(48)
  
  Pages: 8453-8453
- NAID
  120006981363
- Data Source
  KAKENHI-PROJECT-17790028
[Journal Article] Synthesis of 6-arylthio analogs of 2'3'-dideoxy-3'-fluoroguanosine and their effect against hepatitis B virus replication2006
- Author(s)
  T.Torii, T.Onishi, K.Izawa, T.Maruyama, Y.Demizu, J.Neyts, E.D.Clerq
- Journal Title
  
  Nucleotides, Nucleotides ＆ Nucleic Acids 25(4-6)
  
  Pages: 655-655
- Data Source
  KAKENHI-PROJECT-17790028
[Journal Article] Electrochemical oxidation of L-prolinol derivative protected with 1-alkoxy-2,2,2-trifluoroethyl group2006
- Author(s)
  O.Onomura, Y.Ishida, T.Maki, D.Minato, Y.Demizu, Y.Matsumura
- Journal Title
  
  Electrochemistry 74(8)
  
  Pages: 645-645
- NAID
  130002150955
- Data Source
  KAKENHI-PROJECT-17790028
[Journal Article] Side-Chain Chiral Centers of Amino Acid and Helical Screw Handedness of Its Peptides2005
- Author(s)
  M.Tanaka, K.Anan, Y.Demizu, M.Kurihara, M.Doi, H.Suemune
- Journal Title
  
  Journal of the American Chemical Society 127(33)
  
  Pages: 11570-11570
- Data Source
  KAKENHI-PROJECT-17790028
[Journal Article] Reaction of O6-Methylguanosine with Nitrite in the Presence of Carboxylic Acid : Synthesis of the Purin-2-yl Carboxylate2005
- Author(s)
  T.Maruyama, N.Moriwaka, Y.Demizu, M.Ohtsuka
- Journal Title
  
  Tetrahedron Letters 46(47)
  
  Pages: 8225-8225
- Data Source
  KAKENHI-PROJECT-17790028
[Journal Article] Facile synthesis of stereoisomers of the non-secosteroidal ligand LG190178 and their evaluation using the mutant vitamin D receptor
- Author(s)
  Y.Demizu, A.Nakatsu, S.Honzawa, A.Yamashita, T.Sugiura, A.Kittaka, S.Kato, H.Okuda, M.Kurihara
- Journal Title
  
  Lett.Org.Chem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Conformational studies on peptides containing α,α-disubstituted α-amno acids : chiral cyclic ,α,α-disubstituted α-amino acidas an α-helical inducer
- Author(s)
  Y.Demizu, M.Doi, M.Kurihara, H.Okuda, M.Nagano, H.Suemune, M.Tanaka
- Journal Title
  
  Org. Biomol.Chem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Journal Article] Solid-phase nucleophilic fluorination
- Author(s)
  Y.Demizu, K.Sano, N.Terayama, W.Hakamata, Y.Sato, H.Inoue, H.Okuda, M.Kurihara
- Journal Title
  
  Synth. Commun. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790018
[Patent] 新規化合物及び医薬組成物2021
- Inventor(s)
  2.出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
- Industrial Property Rights Holder
  2.出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-115706
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21K05320
[Patent] 新規化合物及び医薬組成物2021
- Inventor(s)
  出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
- Industrial Property Rights Holder
  出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-115706
- Filing Date
  2021
- Data Source
  KAKENHI-PLANNED-18H05502
[Patent] 新規化合物及び医薬組成物2021
- Inventor(s)
  2.出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
- Industrial Property Rights Holder
  2.出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-016808
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-17K08385
[Patent] 新規化合物及び医薬組成物2021
- Inventor(s)
  出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
- Industrial Property Rights Holder
  出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-016808
- Filing Date
  2021
- Data Source
  KAKENHI-PLANNED-18H05502
[Patent] 新規化合物及び抗コロナウイルス剤2020
- Inventor(s)
  出水庸介ら
- Industrial Property Rights Holder
  出水庸介ら
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-195723
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-17K08385
[Patent] 構築物，及び，カーゴ分子を細胞内に輸送する方法2018
- Inventor(s)
  出水庸介，三澤隆史，大岡伸通，内藤幹彦
- Industrial Property Rights Holder
  出水庸介，三澤隆史，大岡伸通，内藤幹彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-000461
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-26460169
[Patent] 構築物，及び，カーゴ分子を細胞内に輸送する方法2018
- Inventor(s)
  出水庸介，三澤隆史，大岡伸通，内藤幹彦
- Industrial Property Rights Holder
  出水庸介，三澤隆史，大岡伸通，内藤幹彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-000461
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-17K08385
[Patent] 細胞膜透過性を有するペプチド，構築物，及び，カーゴ分子を細胞内に輸送する方法2017
- Inventor(s)
  出水庸介，栗原正明，三澤隆史
- Industrial Property Rights Holder
  出水庸介，栗原正明，三澤隆史
- Industrial Property Rights Type
  特許
- Filing Date
  2017-02-02
- Overseas
- Data Source
  KAKENHI-PROJECT-26460169
[Patent] 細胞膜透過性を有するペプチド，構築物，及び，カーゴ分子を細胞内に輸送する方法2016
- Inventor(s)
  出水庸介，栗原正明，三澤隆史
- Industrial Property Rights Holder
  出水庸介，栗原正明，三澤隆史
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-018416
- Filing Date
  2016-02-02
- Data Source
  KAKENHI-PROJECT-26460169
[Patent] ラムノシドエステル誘導体およびその製造方法2010
- Inventor(s)
  尾野村治、出水庸介、久保裕紀、岩崎史哲
- Industrial Property Rights Holder
  尾野村治、出水庸介、久保裕紀、岩崎史哲
- Patent Publication Number
  2010-030916
- Acquisition Date
  2010-02-12
- Data Source
  KAKENHI-PROJECT-21790018
[Patent] ピラノシドエステル化合物およびその製造方法2009
- Inventor(s)
  尾野村治、出水庸介、岩崎史哲
- Industrial Property Rights Holder
  尾野村治、出水庸介、岩崎史哲
- Patent Publication Number
  2009-215175
- Acquisition Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-21790018
[Patent] 光学活性α-スルポニルオキシカルボン酸アミド誘導体及びそれらの製造方法2009
- Inventor(s)
  尾野村治、出水庸介、岩崎史哲
- Industrial Property Rights Holder
  尾野村治、出水庸介、岩崎史哲
- Patent Publication Number
  2009-091327
- Acquisition Date
  2009-04-30
- Data Source
  KAKENHI-PROJECT-21790018
[Patent] グルコシドエステル誘導体およびその製造方法2009
- Inventor(s)
  尾野村治、出水庸介、岩崎史哲
- Industrial Property Rights Holder
  尾野村治、出水庸介、岩崎史哲
- Patent Publication Number
  2009-221161
- Acquisition Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21790018
[Patent] キシロシドエステル誘導体およびその製造方法2009
- Inventor(s)
  尾野村治、出水庸介、岩崎史哲
- Industrial Property Rights Holder
  尾野村治、出水庸介、岩崎史哲
- Patent Publication Number
  2009-227610
- Acquisition Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790018
[Patent] 光学活性アミノ酸エステル誘導体,および光学活性アミノアセタール誘導体の製造方法2009
- Inventor(s)
  尾野村治、出水庸介、山本博将
- Industrial Property Rights Holder
  尾野村治、出水庸介、山本博将
- Patent Publication Number
  2009-227594
- Acquisition Date
  2009-10-08
- Data Source
  KAKENHI-PROJECT-21790018
[Patent] 光学活性モノスルホネート化合物の製造方法2008
- Inventor(s)
  松村功啓, 尾野村治, 出水庸介
- Industrial Property Rights Holder
  松村功啓, 尾野村治, 出水庸介
- Patent Publication Number
  2008-290981
- Acquisition Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] 光学活性α-アシルオキシリン酸誘導体の製造方法2008
- Inventor(s)
  尾野村冶, 出水庸介, 森山敦, 岩崎史哲
- Industrial Property Rights Holder
  尾野村冶, 出水庸介, 森山敦, 岩崎史哲
- Industrial Property Number
  2008-286370
- Filing Date
  2008-11-07
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] 脂肪族ジカルボン酸化合物の製造方法2008
- Inventor(s)
  尾野村冶, 出水庸介, 岩崎史哲
- Industrial Property Rights Holder
  尾野村冶, 出水庸介, 岩崎史哲
- Industrial Property Number
  2008-025594
- Filing Date
  2008-02-05
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] ピラノシドジエステル化合物及びその製造方法2008
- Inventor(s)
  尾野村冶, 出水庸介, 岩崎史哲
- Industrial Property Rights Holder
  尾野村冶, 出水庸介, 岩崎史哲
- Industrial Property Number
  2008-057503
- Filing Date
  2008-03-07
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] キシロシドエステル誘導体およびその製造方法2008
- Inventor(s)
  尾野村冶, 出水庸介, 岩崎史哲
- Industrial Property Rights Holder
  尾野村冶, 出水庸介, 岩崎史哲
- Industrial Property Number
  2008-075320
- Filing Date
  2008-03-24
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] グルコシドエステル誘導体およびその製造方法2008
- Inventor(s)
  尾野村冶, 出水庸介, 岩崎史哲
- Industrial Property Rights Holder
  尾野村冶, 出水庸介, 岩崎史哲
- Industrial Property Number
  2008-068124
- Filing Date
  2008-03-17
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] ピラノシドジエステル化合物及びその製造方法2008
- Inventor(s)
  尾野村治, 出水庸介, 岩崎史哲
- Industrial Property Rights Holder
  尾野村治, 出水庸介, 岩崎史哲
- Industrial Property Number
  2008-057503
- Filing Date
  2008-03-07
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] グルコシドエステル誘導体およびその製造方法2008
- Inventor(s)
  尾野村治, 出水庸介, 岩崎史哲
- Industrial Property Rights Holder
  尾野村治, 出水庸介, 岩崎史哲
- Industrial Property Number
  2008-068124
- Filing Date
  2008-03-17
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] 光学活性アミノ酸エステル誘導体、及び光学活性アミノアセタール誘導体の製造方法2008
- Inventor(s)
  尾野村冶, 出水庸介, 山本博将
- Industrial Property Rights Holder
  尾野村冶, 出水庸介, 山本博将
- Industrial Property Number
  2008-072911
- Filing Date
  2008-03-21
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] 光学活性アミノ酸エステル誘導体、及び光学活性アミノアセタール誘導体の製造方法2008
- Inventor(s)
  尾野村治, 出水庸介, 山本博将
- Industrial Property Rights Holder
  尾野村治, 出水庸介, 山本博将
- Industrial Property Number
  2008-072911
- Filing Date
  2008-03-21
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] α、α-ジ置換環状含窒素化合物の製造方法2008
- Inventor(s)
  松村功啓, 尾野村冶, 出水庸介
- Industrial Property Rights Holder
  松村功啓, 尾野村冶, 出水庸介
- Patent Publication Number
  2008-240106
- Acquisition Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] 光学活性ビスオキサゾリン-銅錯体を不斉触媒とするN-保護アミノアルコール化合物の不斉エステル化反応2008
- Inventor(s)
  松村功啓, 尾野村治, 出水庸介
- Industrial Property Rights Holder
  松村功啓, 尾野村治, 出水庸介
- Patent Publication Number
  2008-037865
- Acquisition Date
  2008-02-21
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] 含窒素レドックス触媒2008
- Inventor(s)
  松村功啓, 尾野村治, 出水庸介
- Industrial Property Rights Holder
  松村功啓, 尾野村治, 出水庸介
- Filing Date
  2008-03-28
- Overseas
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] 含窒素レドックス触媒2008
- Inventor(s)
  松村功啓, 尾野村冶, 出水庸介
- Industrial Property Rights Holder
  松村功啓, 尾野村冶, 出水庸介
- Filing Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] 脂肪族ジカルボン酸化合物の製造方法2008
- Inventor(s)
  尾野村治, 出水庸介, 岩崎史哲
- Industrial Property Rights Holder
  尾野村治, 出水庸介, 岩崎史哲
- Industrial Property Number
  2008-025594
- Filing Date
  2008-02-05
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] 光学活性ビスオキサゾリン-銅錯体を不斉触媒おするN-保護アミノアルコール化合物の不斉エステル化反応2008
- Inventor(s)
  松村功啓, 尾野村冶, 出水庸介
- Industrial Property Rights Holder
  松村功啓, 尾野村冶, 出水庸介
- Patent Publication Number
  2008-037865
- Acquisition Date
  2008-02-21
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] 光学活性α-アシルオキシリン酸誘導体の製造方法2008
- Inventor(s)
  尾野村治, 出水庸介, 森山敦, 岩崎史哲
- Industrial Property Rights Holder
  尾野村治, 出水庸介, 森山敦, 岩崎史哲
- Industrial Property Number
  2008-286370
- Filing Date
  2008-11-07
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] ラムノシドエステル誘導体およびその製造方法2008
- Inventor(s)
  尾野村治, 出水庸介, 久保裕紀, 岩崎史哲
- Industrial Property Rights Holder
  尾野村治, 出水庸介, 久保裕紀, 岩崎史哲
- Industrial Property Number
  2008-192243
- Filing Date
  2008-07-25
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] 光学活性モノスルホネート化合物の製造方法2008
- Inventor(s)
  松村功啓, 尾野村冶, 出水庸介
- Industrial Property Rights Holder
  松村功啓, 尾野村冶, 出水庸介
- Patent Publication Number
  2008-290981
- Acquisition Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] ラムノシドエステル誘導体およびその製造方法2008
- Inventor(s)
  尾野村冶, 出水庸介, 久保裕紀, 岩崎史哲
- Industrial Property Rights Holder
  尾野村冶, 出水庸介, 久保裕紀, 岩崎史哲
- Industrial Property Number
  2008-192243
- Filing Date
  2008-07-25
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] α, α-ジ置換環状含窒素化合物の製造方法2008
- Inventor(s)
  松村功啓, 尾野村治, 出水庸介
- Industrial Property Rights Holder
  松村功啓, 尾野村治, 出水庸介
- Patent Publication Number
  2008-240106
- Acquisition Date
  2008-10-09
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] キシロシドエステル誘導体およびその製造方法2008
- Inventor(s)
  尾野村治, 出水庸介, 岩崎史哲
- Industrial Property Rights Holder
  尾野村治, 出水庸介, 岩崎史哲
- Industrial Property Number
  2008-075320
- Filing Date
  2008-03-24
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] 光学活性α-スルホニルオキシカルボン酸アミド誘導体及びそれらの製造方法2007
- Inventor(s)
  尾野村治、出水庸介、岩崎史哲
- Industrial Property Rights Holder
  尾野村治、出水庸介、岩崎史哲
- Industrial Property Number
  2007-265700
- Filing Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-19790017
[Patent] 光学活性α-スルホニルオキシカルボン酸アミド誘導体及びそれらの製造方法2007
- Inventor(s)
  尾野村冶, 出水庸介, 岩崎史哲
- Industrial Property Rights Holder
  尾野村冶, 出水庸介, 岩崎史哲
- Industrial Property Number
  2007-265700
- Filing Date
  2007-10-11
- Data Source
  KAKENHI-PROJECT-19790017
[Presentation] CRBNリガンドに着目したH-PGDS分解誘導剤の構造活性相関研究2023
- Author(s)
  大澤陽，黒原崇，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] PROTACに利用できる新規デグロン配列の探索2023
- Author(s)
  髙野玲奈，黒原崇，大岡伸通，大金賢司，井上貴雄，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 汎用的なPROTAC固相合成法の開発2023
- Author(s)
  許涵喬，黒原崇，辻厳一郎，大岡伸通，柴田識人，井上貴雄，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 汎用的なPROTAC固相合成法の開発2023
- Author(s)
  許涵喬，黒原崇，辻厳一郎，大岡伸通，柴田識人，井上貴雄，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 糖・塩基部デュアル修飾型人工核酸を用いた抗CHIP/STUB1アプタマーの創出2023
- Author(s)
  石田健太，千賀陽子，仁田峠海斗，岡正啓，大岡伸通，星野秀和，出水庸介，井上貴雄，小比賀聡，笠原勇矢
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] ペプチド核酸のinvasionを目指したジカチオンを持つシトシン誘導体の合成2023
- Author(s)
  森谷俊介，米津実咲，近藤有寿，出水庸介，栗原正明，橘高敦史，杉山亨
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 中分子ペプチド医薬品の現状と展望2023
- Author(s)
  出水庸介
- Organizer
  日本化学会第103春季年会2023イノベーション共創プログラム（CIP）セッション「バイオ医薬品の最前線を支えるスマートケミストリー」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 大麻草由来成分の構造類似体の分析法に関する検討2023
- Author(s)
  河村麻衣子，三澤隆史，辻厳一郎，黒原崇，伊藤美千穂，出水庸介，花尻（木倉）瑠理
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] ロイシンとジ置換アミノ酸のヘテロペプチドにおけるジ置換アミノ酸の種類によるペプチド二次構造への影響評価2023
- Author(s)
  加藤巧馬，出水庸介，田中正一，浅野晶子，土井光暢
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] delta9-THC-O-acetateおよびdelta8-THC-O-acetateのヒト肝臓ミクロゾームによる酵素化学的加水分解と∆9-THCおよび∆8-THC生成2023
- Author(s)
  Jorge Carlos Pineda Garcia，趙爽利，李任時，花尻瑠理，出水庸介，田中嘉孝，石井祐次
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 生体内安定性の向上を志向したデコイ核酸型PROTACの創製2023
- Author(s)
  永沼美弥子，大岡伸通，辻厳一郎，内藤幹彦，井上貴雄，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] H-PGDSを標的とするPROTACの構造活性相関研究2023
- Author(s)
  黒原崇，大澤陽，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 多剤耐性菌感染症の治療を志向した新規抗菌性ヘリカルペプチドの開発2023
- Author(s)
  三澤隆史，平野元春，倉島恵愛，山崎聖司，西野邦彦，出水庸介
- Organizer
  第96回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] H-PGDSを標的とするPROTACの構造活性相関研究2023
- Author(s)
  黒原崇，大澤陽，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] JP各条品の試験法に用いる試薬・溶媒量の低減に向けた検討2023
- Author(s)
  三澤隆史，辻厳一郎，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 疎水性ステープルペプチドによるDDSキャリアの開発2023
- Author(s)
  土屋圭輔，堀越奏子，三澤隆史，福原潔，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] キヌレニン産生を抑制する環状デプシペプチドKNP-1の構造決定および全合成研究2023
- Author(s)
  古内志拓，人見悠毅，佐々木智未，岡本岳大，辻厳一郎，黒原崇，出水庸介，大野修，松野研司
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] エキシマー蛍光を利用した蛍光性糖鎖標識試薬の開発2023
- Author(s)
  伊藤海結，関根優莉奈，正田卓司，橋井則貴，原園景，石井明子，井上英史，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Wnt/β-catenin経路阻害ペプチドのin silico設計2023
- Author(s)
  藤田陽，土屋圭輔，木吉真人，石井明子，三澤隆史，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] CRBNリガンドに着目したH-PGDS分解誘導剤の構造活性相関研究2023
- Author(s)
  大澤陽，黒原崇，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 連結フロー反応による医薬品原薬の連続生産に関する技術要件の抽出2023
- Author(s)
  正田卓司，青木尚代，出水庸介，坂本知昭
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 組織選択的キャリア開発を目的としたヘリカルペプチドのデザイン2023
- Author(s)
  伊藤貴仁，三澤隆史，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 組織選択的キャリア開発を目的としたヘリカルペプチドのデザイン2023
- Author(s)
  伊藤貴仁，三澤隆史，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] アンチセンス核酸の効率的細胞内移行を志向した疎水性膜透過性ペプチドの探索2023
- Author(s)
  田村早季，辻厳一郎，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 両親媒性ステープルペプチドを利用した核酸の細胞内輸送2023
- Author(s)
  平野元春，横尾英知，大庭誠，三澤隆史，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 多目的ベイズ最適化を用いた非天然アミノ酸を考慮した抗菌ペプチド設計手法の検討2023
- Author(s)
  村上優貴，石田祥一，出水庸介，寺山慧
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 高分解能固体NMRを用いたラニチジン塩酸塩の結晶形の解析2023
- Author(s)
  横尾英知，田中誠司，山本栄一，辻厳一郎，出水庸介，内山奈穂子
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] PROTACに利用できる新規デグロン配列の探索2023
- Author(s)
  髙野玲奈，黒原崇，大岡伸通，大金賢司，井上貴雄，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 中分子ペプチド医薬品の現状と展望2023
- Author(s)
  出水庸介
- Organizer
  日本化学会第103春季年会2023イノベーション共創プログラム（CIP）セッション「バイオ医薬品の最前線を支えるスマートケミストリー」
- Invited
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 両親媒性ステープルペプチドによるpDNA，mRNA，及びsiRNAの効率的な細胞内輸送2023
- Author(s)
  平野元春，横尾英知，大庭誠，三澤隆史，出水庸介
- Organizer
  日本薬学会第143回年会シンポジウム，若手研究者が拓くニューモダリティ創薬研究～革新的医薬品の創出に向けて～
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 生体内安定性の向上を志向したデコイ核酸型PROTACの創製2023
- Author(s)
  永沼美弥子，大岡伸通，辻厳一郎，内藤幹彦，井上貴雄，出水庸介
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 大麻成分由来23化合物の一斉分析法の検討2023
- Author(s)
  水谷佐久美，河村麻衣子，田中理恵，三澤隆史，辻厳一郎，黒原崇，伊藤美千穂，出水庸介，花尻（木倉）瑠理
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 糖・塩基部デュアル修飾型人工核酸を用いた抗CHIP/STUB1アプタマーの創出2023
- Author(s)
  石田健太，千賀陽子，仁田峠海斗，岡正啓，大岡伸通，星野秀和，出水庸介，井上貴雄，小比賀聡，笠原勇矢
- Organizer
  日本薬学会第143回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 標的リガンドにオリゴヌクレオチドを応用したPROTACの創製2022
- Author(s)
  永沼美弥子，大岡伸通，辻厳一郎，松野研司，内藤幹彦，井上貴雄，出水庸介
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of chimeric molecules that degrade the estrogen receptor using decoy oligonucleotide ligands2022
- Author(s)
  Naganuma, M., Ohoka, N., Tsuji, G., Matsuno, K., Naito, M., Inoue, T., Demizu, Y.
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 高い抗菌活性を有するステープルペプチドの創製2022
- Author(s)
  伊藤貴仁，三澤隆史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 非天然型アミノ酸含有ヘリカルペプチドによるVDR転写阻害剤の創製2022
- Author(s)
  田京茉実，三澤隆史，平田尚也，諫田泰成，石田寛明，山本恵子，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] シャペロン介在型オートファジー誘導手法の開発2022
- Author(s)
  早川英佑, 山下博子, 佐藤伸一, 橋本祐一, 出水庸介, 石川稔, 友重秀介
- Organizer
  日本ケミカルバイオロジー学会第16年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] ヘリックス型膜透過生ペプチドを用いたアンチセンス核酸の細胞内送達2022
- Author(s)
  高田浩行，土屋圭輔，出水庸介
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 合理的設計による高活性PROTACの開発2022
- Author(s)
  出水庸介
- Organizer
  第95回日本生化学会大会シンポジウム「ユビキチン・プロテアソーム研究のニューフロンティア」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] E3リガンドに着目したH-PGDS分解誘導剤の構造活性相関研究2022
- Author(s)
  大澤陽，黒原崇，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] β-カテニンの機能を制御する新規ヘリカルペプチドの開発2022
- Author(s)
  土屋圭輔，木吉真人，三澤隆史，石井明子，福原潔，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 合理的設計による高活性PROTACの開発2022
- Author(s)
  出水庸介
- Organizer
  第95回日本生化学会大会シンポジウム「ユビキチン・プロテアソーム研究のニューフロンティア」
- Invited
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Towards development of protein degraders for targeting signal transducer and activator of transcription 3 (STAT3)2022
- Author(s)
  Shih Po-C, Naganuma M, Tsuji G, Demizu Y, Naito M.
- Organizer
  Ubiquitin New Frontier from Neo-biology to Targeted Protein Degradation
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 造血器型プロスタグランジンD合成酵素選択的タンパク質分解誘導剤の開発2022
- Author(s)
  柴田識人，横尾英知，遠藤彬則，伊藤貴仁，栁瀨雄太，村上優貴，藤井清永，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of nanoparticle-based protein degradation inducers based on nucleic acid delivery2022
- Author(s)
  横尾英知，内田智士，出水庸介，大庭誠
- Organizer
  第59回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 多剤耐性菌感染症治療を目的とした両親媒性ヘリカルペプチドの開発2022
- Author(s)
  三澤隆史，平野元春，倉島恵愛，山崎聖司，西野邦彦，出水庸介
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] デコイ核酸をリガンドとしたエストロゲン受容体分解誘分子の開発2022
- Author(s)
  永沼美弥子，大岡伸通，辻村はるな，松野研司，内藤幹彦，井上貴雄，辻厳一郎，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 非天然型アミノ酸含有ヘリカルペプチドによるVDR転写阻害剤の創製2022
- Author(s)
  田京茉実，三澤隆史，平田尚也，諫田泰成，石田寛明，山本恵子，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of potent PROTACs targeting hematopoietic prostaglandin D synthase via in silico design2022
- Author(s)
  Yosuke Demizu
- Organizer
  Ubiquitin New Frontier from Neo-biology to Targeted Protein Degradation
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] PreQ1塩基を持つペプチド核酸の合成とその性質2022
- Author(s)
  森谷俊介、米田有希、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史、杉山　亨
- Organizer
  日本薬学会第１４２年会
- Data Source
  KAKENHI-PROJECT-18K06557
[Presentation] 二次構造制御型ペプチドによるWnt/β-カテニン経路阻害剤の創製2022
- Author(s)
  土屋圭輔，木吉真人，橋井則貴，藤田陽，石井明子，福原潔，三澤隆史，出水庸介
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] H-PGDS分解誘導剤の構造活性相関研究2022
- Author(s)
  村上優貴，黒原崇，横尾英知，伊藤貴仁，柳瀬雄太，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of CPP-conjugated LRH-1-derived peptides inhibiting Wnt/β-catenin signaling pathway2022
- Author(s)
  土屋圭輔，木吉真人，橋井則貴，藤田陽，石井明子，福原潔，三澤隆史，出水庸介
- Organizer
  第59回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Specific degrader of hematopoietic prostaglandin D synthase prevented the progression of dilated cardiomyopathy in Duchenne muscular dystrophy2022
- Author(s)
  Maeyama, Y., Hosokawa, Y., Hamamura, K., Yokoo, H., Shibata, N., Naito, M., Demizu, Y., Aritake, K.
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Synthesis of dicationic cytosine derivative for peptide nucleic acid2022
- Author(s)
  森谷俊介，Yonezu Misaki,Kondo Yuzu，出水庸介，栗原正明，橘高敦史，杉山亨
- Organizer
  第59回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] アミロイドβの神経毒性を抑制する新規ペプチドの開発2022
- Author(s)
  福原潔，森一憲，沖山佳生，三澤隆史，水野美麗，出水庸介，柴沼質子，大野彰子
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 造血器型プロスタグランジンD合成酵素選択的タンパク質分解誘導剤の開発2022
- Author(s)
  柴田識人，横尾英知，遠藤彬則，伊藤貴仁，栁瀨雄太，村上優貴，藤井清永，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] リンカー構造に着目したH-PGDS分解誘導剤の構造活性相関研究2022
- Author(s)
  大澤陽，黒原崇，横尾英知，伊藤貴仁，栁瀨雄太，柴田識人，大槻崇，松藤寛，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 固相法によるPROTACの迅速合成2022
- Author(s)
  許涵喬，黒原崇，柴田識人，大岡伸通，井上貴雄，内藤幹彦，出水庸介
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] ノルジェストメットおよび17β-異性体の合成とプロゲステロン活性の評価2022
- Author(s)
  黒原崇，伊藤貴仁，辻厳一郎，三澤隆史，横尾英知，栁瀨雄太，正田卓司，坂井隆敏，細江潤子，内山奈穂子，穐山浩，出水庸介
- Organizer
  第8回次世代を担う若手のためのレギュラトリーサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] デコイ核酸をリガンドとしたエストロゲン受容体分解誘分子の開発2022
- Author(s)
  永沼美弥子，大岡伸通，辻村はるな，松野研司，内藤幹彦，井上貴雄，辻厳一郎，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthase2022
- Author(s)
  Osawa H, Kurohara T, Murakami Y, Shibata N, Naito M, Demizu Y.
- Organizer
  Ubiquitin New Frontier from Neo-biology to Targeted Protein Degradation
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] リンカー構造に着目したH-PGDS分解誘導剤の構造活性相関研究2022
- Author(s)
  大澤陽，黒原崇，横尾英知，伊藤貴仁，栁瀨雄太，柴田識人，大槻崇，松藤寛，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 薬物修飾部位の異なる抗体薬物複合体の特性解析2022
- Author(s)
  青山道彦，多田稔，三澤隆史，出水庸介，石井明子
- Organizer
  第1回日本抗体学会学術大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] デコイ核酸を利用したキメラ分子による標的タンパク質分解2022
- Author(s)
  大岡伸通，内藤幹彦，出水庸介
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] リンカー構造に着目したH-PGDS分解誘導剤の構造活性相関研究2022
- Author(s)
  大澤陽，黒原崇，横尾英知，伊藤貴仁，栁瀨雄太，柴田識人，大槻崇，松藤寛，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 固相法によるタンパク質分解誘導剤の迅速・効率的合成2022
- Author(s)
  許涵喬，黒原崇，横尾英知，辻厳一郎，柴田識人，大岡伸通，井上貴雄，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 多様なカチオン性アミノ酸を導入した抗菌ペプチドフォルダマーの開発2022
- Author(s)
  髙田真有，伊藤貴仁，平野元春，土屋圭輔，三澤隆史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] In silicoスクリーニングによるSTINGリガンドの効率的探索と機能評価2022
- Author(s)
  辻厳一郎，栁瀨雄太，柴田識人，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Development of potent PROTACs targeting hematopoietic prostaglandin D synthase via in silico design2022
- Author(s)
  Demizu, Y.
- Organizer
  The International Symposium in Tokyo, Ubiquitin New Frontier “from Neo-Biology to Targeted Protein Degradation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 固相法によるタンパク質分解誘導剤の迅速・効率的合成2022
- Author(s)
  許涵喬，黒原崇，横尾英知，辻厳一郎，柴田識人，大岡伸通，井上貴雄，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthase2022
- Author(s)
  大澤陽，黒原崇，村上優貴，柴田識人，内藤幹彦，出水庸介
- Organizer
  CBI学会2022年大会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 中分子ペプチドによるβ-catenin関連シグナル経路阻害剤の開発2022
- Author(s)
  土屋圭輔，木吉真人，藤田陽，三澤隆史，石井明子，福原潔，出水庸介
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] β-カテニンの機能を制御する新規ヘリカルペプチドの開発2022
- Author(s)
  土屋圭輔，木吉真人，三澤隆史，石井明子，福原潔，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 合成オピオイドnitazene類14化合物の識別法に関する検討2022
- Author(s)
  水谷佐久美，河村麻衣子，黒原崇，三澤隆史，出水庸介，袴塚高志，花尻（木倉）瑠理
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Towards development of protein degraders for targeting signal transducer and activator of transcription 3 (STAT3)2022
- Author(s)
  Shih, Po-C., Naganuma, M., Tsuji, G., Demizu, Y., Naito, M.
- Organizer
  The International Symposium in Tokyo, Ubiquitin New Frontier “from Neo-Biology to Targeted Protein Degradation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] H-PGDS分解誘導剤のリンカー構造に着目した構造活性相関研究2022
- Author(s)
  黒原崇，大澤陽，伊藤貴仁，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  ケミカルバイオロジー第16回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Specific degrader of hematopoietic prostaglandin D synthase prevented the progression of dilated cardiomyopathy in Duchenne muscular dystrophy2022
- Author(s)
  Maeyama, Y., Hosokawa, Y., Hamamura, K., Yokoo, H., Shibata, N., Naito, M., Demizu, Y., Aritake, K.
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 動物用ホルモン剤の高純度標品合成と評価に関する研究2022
- Author(s)
  黒原崇，伊藤貴仁，辻厳一郎，三澤隆史，横尾英知，栁瀨雄太，正田卓司，坂井隆敏，細江潤子，内山奈穂子，穐山浩，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 核酸分子の効率的な細胞内送達を可能とする両親媒性ペプチドフォルダマーの開発2022
- Author(s)
  平野元春，横尾英知，大庭誠，三澤隆史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthase2022
- Author(s)
  Osawa, H., Kurohara, T., Murakami, Y., Shibata, N., Naito, M., Demizu, Y.
- Organizer
  The International Symposium in Tokyo, Ubiquitin New Frontier “from Neo-Biology to Targeted Protein Degradation
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] ヘリカルテンプレートを連結したオリゴアルギニンを用いたプラスミドDNAの細胞内デリバリー2022
- Author(s)
  横尾英知，三澤隆史，加藤巧馬，田中正一，出水庸介，大庭誠
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] デコイ核酸を利用したキメラ分子による標的タンパク質分解2022
- Author(s)
  大岡伸通，内藤幹彦，出水庸介
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] β-カテニンの機能を制御する新規ヘリカルペプチドの開発2022
- Author(s)
  土屋圭輔，木吉真人，三澤隆史，石井明子，福原潔，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] The differentiation of LSD and its 17 related compounds by GC-EI-MS and GC-CI-QTOF-MS2022
- Author(s)
  Kikura-Hanajiri, R., Mizutani, S., Kawamura, M., Tanaka, R., Shoda, T., Demizu, Y.
- Organizer
  The 30th Meetings of SFTA, the 59th Annual Meeting of TIAFT
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 造血器型プロスタグランジンD合成酵素選択的タンパク質分解誘導剤の開発2022
- Author(s)
  柴田識人，横尾英知，遠藤彬則，伊藤貴仁，栁瀨雄太，村上優貴，藤井清永，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] NMRフィンガープリント法を用いたペプチドの構造変性検出に関する検討2022
- Author(s)
  三澤隆史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] pecific degrader of hematopoietic prostaglandin D synthase prevented the progression of dilated cardiomyopathy in Duchenne muscular dystrophy2022
- Author(s)
  Maeyama, Y., Hosokawa, Y., Hamamura, K., Yokoo, H., Shibata, N., Naito, M., Demizu, Y., Aritake, K.
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ジフェニルメタン骨格を持つ新規ERαアンタゴニストの創製2022
- Author(s)
  湯山円晴，三澤隆史，出水庸介，金谷貴行，佐藤忠章，栗原正明
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 固相法によるタンパク質分解誘導剤の迅速・効率的合成2022
- Author(s)
  許涵喬，黒原崇，横尾英知，辻厳一郎，柴田識人，大岡伸通，井上貴雄，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] PreQ1塩基を持つペプチド核酸の合成とその性質2022
- Author(s)
  森谷俊介，米田有希,桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史，杉山亨
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 核酸分子の効率的な細胞内送達を可能とする両親媒性ペプチドフォルダマーの開発2022
- Author(s)
  平野元春，横尾英知，大庭誠，三澤隆史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] NMRフィンガープリント法を用いたペプチドの構造変性検出に関する検討2022
- Author(s)
  三澤隆史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] LSD及びLSD構造類似化合物の分析法に関する検討2022
- Author(s)
  河村麻衣子，田中理恵，正田卓司，出水庸介，花尻（木倉）瑠理
- Organizer
  日本法中毒学会第41年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Multi-objective Bayesian optimization of antimicrobial peptides design using non-natural amino acids2022
- Author(s)
  村上優貴，石田祥一，出水庸介，寺山慧
- Organizer
  CBI学会2022年大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] ペプチドの構造変性検出を目指したNMRフィンガープリント法の検討2022
- Author(s)
  三澤隆史，出水庸介
- Organizer
  第8回次世代を担う若手のためのレギュラトリーサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 固相法によるPROTACの迅速合成2022
- Author(s)
  許涵喬，黒原崇，柴田識人，大岡伸通，井上貴雄，内藤幹彦，出水庸介
- Organizer
  第48回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 動物用ホルモン剤の高純度標品合成と評価に関する研究2022
- Author(s)
  黒原崇，伊藤貴仁，辻厳一郎，三澤隆史，横尾英知，栁瀨雄太，正田卓司，坂井隆敏，細江潤子，内山奈穂子，穐山浩，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 多様なカチオン性アミノ酸を導入した抗菌ペプチドフォルダマーの開発2022
- Author(s)
  髙田真有，伊藤貴仁，平野元春，土屋圭輔，三澤隆史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 高い抗菌活性を有するステープルペプチドの創製2022
- Author(s)
  伊藤貴仁，三澤隆史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] アミロイドβの神経毒性を抑制する新規ペプチドの開発2022
- Author(s)
  福原潔，森一憲，沖山佳生，三澤隆史，水野美麗，出水庸介，柴沼質子，大野彰子
- Organizer
  日本農芸化学会2022年度大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 長鎖アルキル基を有するエストロゲン受容体β選択的分解誘導剤の開発2022
- Author(s)
  津田萌菜，正田卓司，平田尚也，諫田泰成，井上英史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 長鎖アルキル基を有するエストロゲン受容体β選択的分解誘導剤の開発2022
- Author(s)
  津田萌菜，正田卓司，平田尚也，諫田泰成，井上英史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of Gilteritinib-based chimeric small molecules that potently induce degradation of FLT3-ITD protein2022
- Author(s)
  Ohoka, N., Suzuki, M., Uchida, T., Tsuji, G., Tsukumo, Y., Yoshida, M., Inoue, T., Demizu, Y., Ohki, H., Naito, M.
- Organizer
  Twelfth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: Translating Knowledge into Practice
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Intracellular plasmid DNA delivery using helical template conjugated oligoarginine2022
- Author(s)
  横尾英知，三澤隆史，加藤巧馬，田中正一，出水庸介，大庭誠
- Organizer
  第59回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] E3リガンドに着目したH-PGDS分解誘導剤の構造活性相関研究2022
- Author(s)
  大澤陽，黒原崇，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] デコイ核酸をリガンドとしたエストロゲン受容体分解誘分子の開発2022
- Author(s)
  永沼美弥子，大岡伸通，辻村はるな，松野研司，内藤幹彦，井上貴雄，辻厳一郎，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 核酸分子の効率的な細胞内送達を可能とする両親媒性ペプチドフォルダマーの開発2022
- Author(s)
  平野元春，横尾英知，大庭誠，三澤隆史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 医薬品中のニトロソアミン類の低減化手法2022
- Author(s)
  出水庸介
- Organizer
  令和4年度M7ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] GC-QTOF-MSによるLSDと異性体の識別法の検討2022
- Author(s)
  水谷佐久美，河村麻衣子，正田卓司，出水庸介，花尻（木倉）瑠理
- Organizer
  日本法中毒学会第41年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] PreQ1塩基を持つペプチド核酸の合成とその性質2022
- Author(s)
  森谷俊介，米田有希,桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史，杉山亨
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] デコイ核酸をリガンドとしたエストロゲン受容体分解誘導分子の創製2022
- Author(s)
  永沼美弥子，大岡伸通，松野研司，内藤幹彦，井上貴雄，辻厳一郎，出水庸介
- Organizer
  ケミカルバイオロジー第16回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Kynurenine産生を抑制する環状デプシペプチド KNP-1の構造決定および全合成研究2022
- Author(s)
  古内志拓，人見悠毅，佐々木智未，岡本岳大，辻厳一郎，黒原崇，出水庸介，大野修，松野研司
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 長鎖アルキル基を有するエストロゲン受容体β選択的アンタゴニストの開発2022
- Author(s)
  正田卓司，出水庸介
- Organizer
  第26回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 標的リガンドにオリゴヌクレオチドを応用したPROTACの創製2022
- Author(s)
  永沼美弥子，大岡伸通，辻厳一郎，松野研司，内藤幹彦，井上貴雄，出水庸介
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 日本薬局方の試験法改正に関する研究～HPLCでの定量試験法設定に向けた検討～2022
- Author(s)
  辻厳一郎，伊藤貴仁，内山奈穂子，細江潤子，出水庸介
- Organizer
  第59回全国衛生化学技術協議会年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Structural development of helix-stabilized block peptides for intracellular delivery of siRNA2022
- Author(s)
  三澤隆史，大岡伸通，平野元春，大庭誠，井上貴雄，出水庸介
- Organizer
  第59回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] デコイ核酸をリガンドとしたエストロゲン受容体分解誘導分子の創製2022
- Author(s)
  永沼美弥子，大岡伸通，松野研司，内藤幹彦，井上貴雄，辻厳一郎，出水庸介
- Organizer
  ケミカルバイオロジー第16回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] In silicoスクリーニングによるSTINGリガンドの効率的探索と機能評価2022
- Author(s)
  辻厳一郎，栁瀨雄太，柴田識人，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] DNAアプタマーを用いたエストロゲン受容体分解誘導剤の開発2022
- Author(s)
  辻村はるな，辻厳一郎，大岡伸通，井上貴雄，内藤幹彦，出水庸介
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthase2022
- Author(s)
  大澤陽，黒原崇，村上優貴，柴田識人，内藤幹彦，出水庸介
- Organizer
  CBI学会2022年大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Synthesis of peptide nucleic acid possessing dicationic cytosine derivative2022
- Author(s)
  Moriya, S., Yonezu, M., Kondo, Y., Demizu, Y., Kurihara, M., Kittaka, A., Sugiyama, T.
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Development of Gilteritinib-based chimeric small molecules that potently induce degradation of FLT3-ITD protein.2022
- Author(s)
  Ohoka N, Suzuki M, Uchida T, Tsuji G, Tsukumo Y, Yoshida M. Inoue T., Demizu Y, Ohki H, Naito M.
- Organizer
  Development of Gilteritinib-based chimeric small molecules that potently induce degradation of FLT3-ITD protein.
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 非天然アミノ酸を加味した低毒性抗菌ペプチド設計に向けた多目的ベイズ最適化の検討2022
- Author(s)
  村上優貴，石田祥一，出水庸介，寺山慧
- Organizer
  2022年日本バイオインフォマティクス学会年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Development of chimeric molecules that degrade the estrogen receptor using decoy oligonucleotide ligands2022
- Author(s)
  Naganuma M, Ohoka N, Tsuji G, Matsuno K, Naito M, Inoue T, Demizu Y.
- Organizer
  The 49th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] デザインSR-HPLC法によるアナトー色素の定量評価の構築2022
- Author(s)
  中森洋紀，布目真梨，辻厳一郎，出水庸介，増本直子，杉本直樹，井之上浩一
- Organizer
  日本食品衛生学会第118回学術講演会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] MOEを活用したPROTACの合理的設計2022
- Author(s)
  出水庸介
- Organizer
  MOEフォーラム2022
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 抗SARS-CoV-2剤創製へ向けた炭素環ヌクレオシドの核酸塩基部構造活性相関研究2022
- Author(s)
  藤沼舞，石綱遥，三澤隆史，出水庸介，栗原正明，満屋裕明，鍬田伸好，服部真一朗，紺野奇重
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] DNAアプタマーを用いたエストロゲン受容体分解誘導剤の開発2022
- Author(s)
  辻村はるな，辻厳一郎，大岡伸通，井上貴雄，内藤幹彦，出水庸介
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] MOEを活用したPROTACの合理的設計2022
- Author(s)
  出水庸介
- Organizer
  MOEフォーラム2022
- Invited
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 長鎖アルキル基を有するエストロゲン受容体β選択的分解誘導剤の開発2022
- Author(s)
  津田萌菜，正田卓司，平田尚也，諫田泰成，井上英史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] シクロスポリン類縁体と細胞膜モデルとの相互作用に関する研究2022
- Author(s)
  中尾瑞佳，原矢佑樹，扇田隆司，斎藤博幸，出水庸介，伊豆津健一，加藤くみ子
- Organizer
  第29回クロマトグラフィーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 高い抗菌活性を有するステープルペプチドの創製2022
- Author(s)
  伊藤貴仁，三澤隆史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 多剤耐性菌感染症治療を目的とした新規抗菌ペプチドフォルダマーの開発2022
- Author(s)
  三澤隆史，平野元春，倉島恵愛，山崎聖司，西野邦彦，出水庸介
- Organizer
  ケミカルバイオロジー第16回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 中分子ペプチド医薬品の現状と展望2022
- Author(s)
  出水庸介
- Organizer
  第23回製剤機械技術学会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 中分子ペプチド医薬品の現状と展望2022
- Author(s)
  出水庸介
- Organizer
  第23回製剤機械技術学会シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 合成オピオイドnitazene類14化合物の識別法に関する検討2022
- Author(s)
  水谷佐久美，河村麻衣子，黒原崇，三澤隆史，出水庸介，袴塚高志，花尻（木倉）瑠理
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 非天然型アミノ酸含有ヘリカルペプチドによるVDR転写阻害剤の創製2022
- Author(s)
  田京茉実，三澤隆史，平田尚也，諫田泰成，石田寛明，山本恵子，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] H-PGDS分解誘導剤のリンカー構造に着目した構造活性相関研究2022
- Author(s)
  黒原崇，大澤陽，伊藤貴仁，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  ケミカルバイオロジー第16回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] シャペロン介在型オートファジー誘導手法の開発2022
- Author(s)
  早川英佑，山下博子，佐藤伸一，橋本祐一，出水庸介，石川稔，友重秀介
- Organizer
  ケミカルバイオロジー第16回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 多様なカチオン性アミノ酸を導入した抗菌ペプチドフォルダマーの開発2022
- Author(s)
  髙田真有，伊藤貴仁，平野元春，土屋圭輔，三澤隆史，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ジフェニルメタン骨格を持つ新規ERαアンタゴニストの創製2022
- Author(s)
  湯山円晴，三澤隆史，出水庸介，金谷貴行，佐藤忠章，栗原正明
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] H-PGDS分解誘導剤の構造活性相関研究2022
- Author(s)
  村上優貴，黒原崇，横尾英知，伊藤貴仁，柳瀬雄太，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] ステープル型αヘリックスペプチド開発品ATSP-7041のin vitroにおける薬物相互作用の評価2022
- Author(s)
  石川リカ，齊藤公亮，三澤隆史，出水庸介，斎藤嘉朗
- Organizer
  日本薬物動体学会第37回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 抗SARS-CoV-2剤創製へ向けた炭素環ヌクレオシドの核酸塩基部構造活性相関研究2022
- Author(s)
  藤沼舞，石綱遥，三澤隆史，出水庸介，栗原正明，満屋裕明，鍬田伸好，服部真一朗，紺野奇重
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] アセタール構造を有する新規ERαアンタゴニストの創製2022
- Author(s)
  湯山円晴，三澤隆史，出水庸介，金谷貴行，佐藤忠章，栗原正明
- Organizer
  第66回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] H-PGDS分解誘導剤の構造活性相関研究2022
- Author(s)
  村上優貴，黒原崇，横尾英知，伊藤貴仁，柳瀬雄太，柴田識人，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第142回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 造血器型プロスタグランジンD合成酵素分解誘導剤の創製2021
- Author(s)
  村上優貴，大澤陽，柴田識人，横尾英知，伊藤貴仁，柳瀬雄太，黒原崇，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 非天然アミノ酸を導入した抗菌ペプチドフォルダマーの開発2021
- Author(s)
  平野元春，齋藤千尋，川野竜司，三澤隆史，出水庸介
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] バーチャルスクリーニングを利用した新規STINGリガンドの効率的探索2021
- Author(s)
  栁瀨雄太，辻厳一郎，柴田識人，出水庸介
- Organizer
  第47回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] シリビニンの高機能化を目指した創薬研究2021
- Author(s)
  水野美麗，森一憲，土屋圭輔，髙木孝士，三澤隆史，出水庸介，柴沼質子，福原潔
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 非天然アミノ酸の導入による両親媒性抗菌ペプチドフォルダマーの創製2021
- Author(s)
  平野元春，齋藤千尋，後藤千尋，川野竜司，三澤隆史，出水庸介
- Organizer
  第52回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] デコイ核酸を利用したタンパク質分解誘導キメラ分子の開発2021
- Author(s)
  大岡伸通，永沼美弥子，辻厳一郎，井上貴雄，出水庸介
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] PreQ1 facilitates DNA strand invasion by PNA2021
- Author(s)
  森谷俊介，桑田啓子，米田有希, 今村保忠，出水庸介，栗原正明，橘高敦史，杉山亨
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] バーチャルスクリーニングを利用した新規STINGリガンドの効率的探索2021
- Author(s)
  栁瀨雄太，辻厳一郎，柴田識人，出水庸介
- Organizer
  第47回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 非天然アミノ酸を導入した抗菌ペプチドフォルダマーの開発2021
- Author(s)
  平野元春，齋藤千尋，川野竜司，三澤隆史，出水庸介
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ラニチジン不純物からのN-ニトロソジメチルアミン（NDMA）の生成：ラニチジン塩酸塩中にNDMA が存在する潜在的な原因2021
- Author(s)
  山本栄一，横尾英知，政田さやか，内山奈穂子，辻厳一郎，袴塚高志，出水庸介，伊豆津健一，合田幸広
- Organizer
  第58回全国衛生科学技術協議会年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 胆汁酸受容体TGR5を標的とした新規レチノイド誘導体の創製2021
- Author(s)
  三澤隆史，照井龍晟，槇島誠，須原義智，出水庸介
- Organizer
  ケミカルバイオロジー第15回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Peptide stapling improves the sustainability of peptide-based degraders against estrogen receptors2021
- Author(s)
  横尾英知，大岡伸通，大庭誠，伊藤貴仁，井上貴雄，内藤幹彦，出水庸介
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 低分子・中分子医薬品開発効率化に資するレギュラトリーサイエンス研究2021
- Author(s)
  出水庸介
- Organizer
  第25回日本がん分子標的治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 高活性・高選択的な造血器型プロスタグランジンD合成酵素分解誘導剤の開発2021
- Author(s)
  横尾英知，柴田識人，遠藤彬則，伊藤貴仁，柳瀬雄太，村上優貴，藤井清永，大庭誠，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  ケミカルバイオロジー第15回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ヘリカル構造制御に基づく高機能生理活性ペプチドの創出2021
- Author(s)
  出水庸介
- Organizer
  日本薬学会第141回年会シンポジウム：中分子創薬研究のフロンティア～生体分子を標的とした機能性ペプチドの創製～
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of ciclesonide analogues that block SARS-CoV-2 RNA replication2021
- Author(s)
  Tsuji, G., Yonemitsu, K., Ito, T., Uema, M., Asakura, H., Demizu, Y.
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] LSD類縁体MiPLAの合成とその性状解析2021
- Author(s)
  正田卓司，河村麻衣子，花尻瑠璃，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of helix-stabilized hydrophobic/cationic-block peptides for intracellular delivery of biomacromolecules2021
- Author(s)
  Misawa, T., Ohoka, N., Hirano, M., Oba, M., Inoue, T., Demizu, Y.
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] カチオン性グアニンアナログを導入したペプチド核酸オリゴマーによるストランドインベージョンの検討2021
- Author(s)
  森谷俊介、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史、杉山　亨
- Organizer
  日本薬学会第１４１年会
- Data Source
  KAKENHI-PROJECT-18K06557
[Presentation] Development of helical antimicrobial peptides containing non-proteinogenic amino acids2021
- Author(s)
  平野元春，齋藤千尋，川野竜司，三澤隆史，出水庸介
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of helical antimicrobial peptides containing non-proteinogenic amino acids2021
- Author(s)
  平野元春，齋藤千尋，川野竜司，三澤隆史，出水庸介
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 国際調和に向けた日本薬局方の医薬品各条における試験法の改定に関する検討：qNMRを利用した類縁物質の純度決定2021
- Author(s)
  辻厳一郎，伊藤貴仁，内山奈穂子，細江潤子，合田幸広，出水庸介
- Organizer
  第3回日本定量ＮＭＲ研究会年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Rationally designed peptide modulators of amyloid-beta toxicity in Alzheimer’s disease2021
- Author(s)
  1.Fukuhara, K., Mori, K., Okiyama, Y., Misawa, T., Mizuno, M., Demizu, Y., Shibanuma, M., Ohno, A.
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of helical peptides containing non-proteinogenic amino acids inhibiting VDR transcription2021
- Author(s)
  田京茉実，三澤隆史，黒原崇，石田寛明，山本恵子，出水庸介
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] アミン骨格を有するc-di-GMP誘導体の合成とバイオフィルム形成阻害評価2021
- Author(s)
  辻厳一郎，池田健太郎，栁瀬雄太，林克彦，工藤由起子，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 高活性・高選択的な造血器型プロスタグランジンD合成酵素分解誘導剤の開発2021
- Author(s)
  横尾英知，柴田識人，遠藤彬則，伊藤貴仁，柳瀬雄太，村上優貴，藤井清永，大庭誠，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  ケミカルバイオロジー第15回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] ビタミンD受容体転写阻害ペプチドの創製2021
- Author(s)
  田京茉実，三澤隆史，黒原崇，石田寛明，山本恵子，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Discovery of a highly potent and selective PROTAC targeting hematopoietic prostaglandin D synthase via in silico design2021
- Author(s)
  Yokoo, H., Shibata, N., Endo, A., Ito, T., Yanase, Y., Murakami, Y., Fujii, K., Saeki, Y., Naito, M., Aritake, K., Demizu, Y.
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] PreQ1 facilitates DNA strand invasion by PNA2021
- Author(s)
  森谷俊介，桑田啓子，米田有希, 今村保忠，出水庸介，栗原正明，橘高敦史，杉山亨
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 抗アデノウイルス活性を期待した2’-デオキシ炭素環ヌクレオシドの合成2021
- Author(s)
  荒井慎之介，斎藤智亜季，水石彩菜，三澤隆史，出水庸介，栗原正明，紺野奇重
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 免疫系制御を指向した新規STINGリガンドの効率的探索2021
- Author(s)
  栁瀨雄太，池田健太郎，辻厳一郎，柴田識人，内藤幹彦，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] PreQ1 facilitates DNA strand invasion by PNA2021
- Author(s)
  森谷俊介、米田有希、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史、杉山　亨
- Organizer
  第５８回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-18K06557
[Presentation] 国際調和に向けた日本薬局方の医薬品各条における試験法の改定に関する検討：qNMRを利用した類縁物質の純度決定2021
- Author(s)
  辻厳一郎，伊藤貴仁，内山奈穂子，細江潤子，合田幸広，出水庸介
- Organizer
  第3回日本定量ＮＭＲ研究会年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 光異性化に基づくエストロゲン受容体の活性制御2021
- Author(s)
  土屋圭輔，梅野智大，辻厳一郎，横尾英知，福原潔，三澤隆史，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 造血器型プロスタグランジンD合成酵素を標的とした選択的タンパク質分解誘導剤の開発2021
- Author(s)
  田識人，横尾英知，遠藤彬則，伊藤貴仁，栁瀨雄太，村上優貴，藤井清永，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Peptide stapling improves the sustainability of peptide-based degraders against estrogen receptors2021
- Author(s)
  横尾英知，大岡伸通，大庭誠，伊藤貴仁，井上貴雄，内藤幹彦，出水庸介
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Discovery of a highly potent and selective PROTAC targeting hematopoietic prostaglandin D synthase via in silico design2021
- Author(s)
  Yokoo, H., Shibata, N., Endo, A., Ito, T., Yanase, Y., Murakami, Y., Fujii, K., Saeki, Y., Naito, M., Aritake, K., Demizu, Y.
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 造血器型プロスタグランジン合成酵素を標的とした分解誘導剤の開発2021
- Author(s)
  横尾英知，柴田識人，永沼美弥子，村上優希，藤井清永，伊藤貴仁，有竹浩介，内藤幹彦，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 活性・高選択的な造血器型プロスタグランジンD合成酵素分解誘導剤の開発2021
- Author(s)
  横尾英知，柴田識人，遠藤彬則，伊藤貴仁，柳瀬雄太，村上優貴，藤井清永，大庭誠，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  ケミカルバイオロジー第15回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Development of helix-stabilized hydrophobic/cationic-block peptides for intracellular delivery of biomacromolecules2021
- Author(s)
  Misawa, T., Ohoka, N., Hirano, M., Oba, M., Inoue, T., Demizu, Y.
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] デコイ核酸を利用したタンパク質分解誘導キメラ分子の開発2021
- Author(s)
  大岡伸通，永沼美弥子，辻厳一郎，井上貴雄，出水庸介
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 非天然アミノ酸を導入した抗菌ペプチドフォルダマーの開発2021
- Author(s)
  平野元春，齋藤千尋，川野竜司，三澤隆史，出水庸介
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 造血器型プロスタグランジンD合成酵素分解誘導剤の創製2021
- Author(s)
  村上優貴，大澤陽，柴田識人，横尾英知，伊藤貴仁，柳瀬雄太，黒原崇，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 非天然型構造を有するペプチド医薬品の安全性評価2021
- Author(s)
  斎藤嘉朗，出水庸介
- Organizer
  第4回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 核内受容体を標的とするペプチド型分解誘導剤の開発2021
- Author(s)
  伊藤貴仁，横尾英知，大岡伸通，内藤幹彦，井上貴雄，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 5,6,7,8-Tetrahydronaphtalene骨格を用いた選択的TGR5アゴニストの開発2021
- Author(s)
  三澤隆史，照井龍晟，栁瀨雄太，横尾英知，槇島誠，須原義智，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of helical antimicrobial peptides containing non-proteinogenic amino acids2021
- Author(s)
  平野元春，齋藤千尋，川野竜司，三澤隆史，出水庸介
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] アゴニストリガンドを利用したLXR分解誘導剤の開発2021
- Author(s)
  許涵喬，辻厳一郎，大岡伸通，内藤幹彦，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 造血器型プロスタグランジンD合成酵素を標的とした選択的タンパク質分解誘導剤の開発2021
- Author(s)
  柴田識人，横尾英知，遠藤彬則，伊藤貴仁，栁瀨雄太，村上優貴，藤井清永，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 胆汁酸受容体TGR5を標的とした新規レチノイド誘導体の創製2021
- Author(s)
  三澤隆史，照井龍晟，槇島誠，須原義智，出水庸介
- Organizer
  ケミカルバイオロジー第15回年会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] ペプチドリガンドを利用したタンパク質分解誘導キメラ分子の開発2021
- Author(s)
  大岡伸通，横尾英知，井上貴雄，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Control of N-nitrosodimethylamine (NDMA) in drug substances2021
- Author(s)
  Yamamoto, E., Yokoo, H., Kan-no, H., Tomita, N., Masada, S., Uchiyama, N., Tsuji, G., Hakamatsuka, T., Demizu, Y., Izutsu, K., Goda, Y.
- Organizer
  The 31st International Symposium on Pharmaceutical and Biomedical Analysis (PBA2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] アゴニストリガンドを利用したLXR分解誘導剤の開発2021
- Author(s)
  許涵喬，辻厳一郎，大岡伸通，内藤幹彦，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] ビタミンD受容体転写阻害ペプチドの創製2021
- Author(s)
  田京茉実，三澤隆史，黒原崇，石田寛明，山本恵子，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 長鎖アルキル基を有する選択的エストロゲン受容体分解誘導剤の開発2021
- Author(s)
  津田萌菜，正田卓司，平田尚也，諫田泰成，井上英史，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 非天然型構造を有するペプチド医薬品の安全性評価2021
- Author(s)
  斎藤嘉朗，出水庸介
- Organizer
  第4回医薬品毒性機序研究会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 中分子ペプチド医薬品の現状と展望2021
- Author(s)
  出水庸介
- Organizer
  第11回CSJ化学フェスタ：バイオ・食品・健康医療、コロナに負けるな！ワクチン・薬分野からの挑戦
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 造血器型プロスタグランジンD合成酵素分解誘導剤の創製2021
- Author(s)
  村上優貴，大澤陽，柴田識人，横尾英知，伊藤貴仁，柳瀬雄太，黒原崇，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of helix-stabilized hydrophobic/cationic-block peptides for intracellular delivery of biomacromolecules2021
- Author(s)
  Misawa, T., Ohoka, N., Hirano, M., Oba, M., Inoue, T., Demizu, Y.
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 中分子ペプチド医薬品の現状と展望2021
- Author(s)
  出水庸介
- Organizer
  第11回CSJ化学フェスタ：バイオ・食品・健康医療、コロナに負けるな！ワクチン・薬分野からの挑戦
- Invited
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] バーチャルスクリーニングを利用した新規STINGリガンドの効率的探索2021
- Author(s)
  栁瀨雄太，辻厳一郎，柴田識人，出水庸介
- Organizer
  第47回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 非天然アミノ酸の導入による両親媒性抗菌ペプチドフォルダマーの創製2021
- Author(s)
  平野元春，齋藤千尋，後藤千尋，川野竜司，三澤隆史，出水庸介
- Organizer
  第52回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 低分子・中分子医薬品開発効率化に資するレギュラトリーサイエンス研究2021
- Author(s)
  出水庸介
- Organizer
  第25回日本がん分子標的治療学会学術集会：RS教育講演
- Invited
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] アプタマーをリガンドとしたエストロゲン受容体分解誘導剤の創製2021
- Author(s)
  辻村はるな，永沼美弥子，大岡伸通，須原義智，松野研司，内藤幹彦，井上貴雄，辻厳一郎，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 両親媒性抗菌ペプチドフォルダマーの合理的設計2021
- Author(s)
  平野元春，齋藤千尋，後藤千尋，川野竜司，三澤隆史，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 造血器型プロスタグランジンD合成酵素を標的とした選択的タンパク質分解誘導剤の開発2021
- Author(s)
  柴田識人，横尾英知，遠藤彬則，伊藤貴仁，栁瀨雄太，村上優貴，藤井清永，佐伯泰，内藤幹彦，有竹浩介，出水庸介
- Organizer
  第94回日本生化学大会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] アゴニストリガンドを利用したLXR分解誘導剤の開発2021
- Author(s)
  許涵喬，辻厳一郎，大岡伸通，内藤幹彦，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 中分子ペプチド医薬品の現状と展望2021
- Author(s)
  出水庸介
- Organizer
  第11回CSJ化学フェスタ：バイオ・食品・健康医療、コロナに負けるな！ワクチン・薬分野からの挑戦
- Invited
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Peptide stapling improves the sustainability of peptide-based degraders against estrogen receptors2021
- Author(s)
  横尾英知，大岡伸通，大庭誠，伊藤貴仁，井上貴雄，内藤幹彦，出水庸介
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of helical peptides containing non-proteinogenic amino acids inhibiting VDR transcription2021
- Author(s)
  田京茉実，三澤隆史，黒原崇，石田寛明，山本恵子，出水庸介
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] デコイ核酸をリガンドとしたエストロゲン受容体分解誘導剤の創製2021
- Author(s)
  永沼美弥子，辻村はるな，大岡伸通，松野研司，須原義智，内藤幹彦，上貴雄，辻厳一郎，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Control of N-nitrosodimethylamine (NDMA) in drug substances2021
- Author(s)
  Yamamoto, E., Yokoo, H., Kan-no, H., Tomita, N., Masada, S., Uchiyama, N., Tsuji, G., Hakamatsuka, T., Demizu, Y., Izutsu, K., Goda, Y.
- Organizer
  The 31st International Symposium on Pharmaceutical and Biomedical Analysis (PBA2021)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] LXRを標的とした分解誘導剤の開発2021
- Author(s)
  許涵喬，辻厳一郎，大岡伸通，内藤幹彦，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Rationally designed peptide modulators of amyloid-beta toxicity in Alzheimer’s disease2021
- Author(s)
  Fukuhara, K., Mori, K., Okiyama, Y., Misawa, T., Mizuno, M., Demizu, Y., Shibanuma, M., Ohno, A.,
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 非天然型アミノ酸含有ヘリカルペプチドによるVDR-コアクチベータ相互作用阻害剤の創製2021
- Author(s)
  田京茉実，佐藤友海，石田寛明，山本恵子，三澤隆史，出水庸介
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ビタミンD受容体転写阻害ペプチドの創製2021
- Author(s)
  田京茉実，三澤隆史，黒原崇，石田寛明，山本恵子，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] ラニチジン不純物からのN-ニトロソジメチルアミン（NDMA）の生成：ラニチジン塩酸塩中にNDMA が存在する潜在的な原因2021
- Author(s)
  山本栄一，横尾英知，政田さやか，内山奈穂子，辻厳一郎，袴塚高志，出水庸介，伊豆津健一，合田幸広
- Organizer
  第58回全国衛生科学技術協議会年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] デコイ核酸を利用したタンパク質分解誘導キメラ分子の開発2021
- Author(s)
  大岡伸通，永沼美弥子，辻厳一郎，井上貴雄，出水庸介
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 非天然アミノ酸の導入による両親媒性抗菌ペプチドフォルダマーの創製2021
- Author(s)
  平野元春，齋藤千尋，後藤千尋，川野竜司，三澤隆史，出水庸介
- Organizer
  第52回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ヘリカル構造制御に基づく高機能生理活性ペプチドの創出2021
- Author(s)
  出水庸介
- Organizer
  日本薬学会第141回年会シンポジウム：中分子創薬研究のフロンティア生体分子を標的とした機能性ペプチドの創製
- Invited
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] カチオン性グアニンアナログを導入したペプチド核酸オリゴマーによるストランドインベージョンの検討2021
- Author(s)
  森谷俊介，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史，杉山亨
- Organizer
  日本薬学会第141回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Discovery of a highly potent and selective PROTAC targeting hematopoietic prostaglandin D synthase via in silico design2021
- Author(s)
  Yokoo, H., Shibata, N., Endo, A., Ito, T., Yanase, Y., Murakami, Y., Fujii, K., Saeki, Y., Naito, M., Aritake, K., Demizu, Y.
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] アセタール構造を有する新規ERαアンタゴニストの創製2021
- Author(s)
  湯山円晴，三澤隆史，出水庸介，金谷貴行，佐藤忠章，栗原正明
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of helical peptides containing non-proteinogenic amino acids inhibiting VDR transcription2021
- Author(s)
  田京茉実，三澤隆史，黒原崇，石田寛明，山本恵子，出水庸介
- Organizer
  第58回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 長鎖アルキル基を有する選択的エストロゲン受容体分解誘導剤の開発2021
- Author(s)
  津田萌菜，正田卓司，平田尚也，諫田泰成，井上英史，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] Development of ciclesonide analogues that block SARS-CoV-2 RNA replication2021
- Author(s)
  Tsuji, G., Yonemitsu, K., Ito, T., Uema, M., Asakura, H., Demizu, Y.
- Organizer
  AIMECS2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] アセタール構造を有する新規ERαアンタゴニストの創製2021
- Author(s)
  湯山円晴，三澤隆史，出水庸介，金谷貴行，佐藤忠章，栗原正明
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-21K05320
[Presentation] 長鎖アルキル基を有する選択的エストロゲン受容体分解誘導剤の開発2021
- Author(s)
  津田萌菜，正田卓司，平田尚也，諫田泰成，井上英史，出水庸介
- Organizer
  第65回日本薬学会関東支部大会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 低分子・中分子医薬品開発効率化に資するレギュラトリーサイエンス研究2021
- Author(s)
  出水庸介
- Organizer
  第25回日本がん分子標的治療学会学術集会：RS教育講演
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of post-functionalizable antimicrobial peptide foldamers2020
- Author(s)
  三澤隆史，平野元春，横尾英知，出水庸介
- Organizer
  第57回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of stapled peptides against inhibiting VDR-coactivator interaction2020
- Author(s)
  佐藤友海，田京茉実，三澤隆史，石田寛明，山本恵子，出水庸介
- Organizer
  第57回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Carbocyclic-2'-deoxynucleosideの合成研究－carbocyclic-2'-deoxyuridineの合成－2020
- Author(s)
  斎藤智亜季，水石彩菜，目黒公太郎，植松明星，原島利彰，林宏典，児玉栄一，三澤隆史，出水庸介，栗原正明，紺野奇重
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 長鎖アルキル基を有するエストロゲン受容体分解誘導剤のERサブタイプ選択性に関する検討2020
- Author(s)
  津田萌菜，正田卓司，井上英史，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ヘリカル構造制御に基づく抗菌ペプチドフォルダマーの開発2020
- Author(s)
  出水庸介
- Organizer
  第58回日本生物物理学会年会シンポジウム：膜の海を旅するペプチド脂質膜とペプチドの相互作用研究の新展開
- Invited
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] c-di-GMP誘導体の合成とバイオフィルム形成阻害評価2020
- Author(s)
  池田健太郎，栁瀨雄太，辻厳一郎，林克彦，工藤（原）由起子，出水庸介
- Organizer
  第34回日本バイオフィルム学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 造血器型プロスタグランジン合成酵素を標的とした分解誘導剤の開発2020
- Author(s)
  横尾英知，柴田識人，永沼美弥子，伊藤貴仁，内藤幹彦，有竹浩介，出水庸介
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 核内受容体分解誘導ペプチドの創製2020
- Author(s)
  横尾英知，大岡伸通，内藤幹彦，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 新規TGR5リガンドの開発2020
- Author(s)
  照井龍晟，三澤隆史，須原義智，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 国内標品確保のためのフェンタニル構造類似化合物の合成研究2020
- Author(s)
  辻厳一郎，三澤隆史，正田卓司，河村麻衣子，花尻（木倉）瑠璃，袴塚高志，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ペプチド核酸によるdouble duplex invasionを応用した目視可能判定可能な一塩基多型検出系の検討2020
- Author(s)
  森谷俊介，笹祐子，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史，杉山亨
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 国際調和に向けた日本薬局方の医薬品各条における試験法の改定に関する研究2020
- Author(s)
  馬庭愛加，辻厳一郎，内山奈穂子，細江潤子，大槻崇，松藤寛，合田幸広，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] プエラリア・ミリフィカ由来kwakhurinの形式全合成と相対モル感度係数を利用したプエラリア・ミリフィカ含有食品中のmiroestrolの定量2020
- Author(s)
  政田さやか，遊佐仁曉，辻厳一郎，横尾英知，細江潤子，新井玲子，田中誠司，出水庸介，袴塚高志，合田幸広，内山奈穂子
- Organizer
  第62回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 新しい細胞膜透過性ペプチドフォルダマーの開発と細胞特異的なsiRNAの導入2020
- Author(s)
  大岡伸通，三澤隆史，内藤幹彦，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 新規TGR5リガンドの開発2020
- Author(s)
  三澤隆史，照井龍晟，槇島眞，須原義智，出水庸介
- Organizer
  日本ビタミン学会第72回大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] LXRを標的とした分解誘導剤の開発2020
- Author(s)
  根本可南子，辻厳一郎，大岡伸通，内藤幹彦，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 非天然型構造を有するペプチド医薬品の非臨床評価の方向性2020
- Author(s)
  斎藤嘉朗，出水庸介
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 非天然型アミノ酸を有するヘリカルペプチドを利用したタンパク質分解誘導キメラ分子の開発2020
- Author(s)
  大岡伸通，横尾英知，内藤幹彦，井上貴雄，出水庸介
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] NMRフィンガープリント法を用いたペプチド医薬品の立体構造解析2020
- Author(s)
  三澤隆史，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 核内受容体分解誘導ペプチドの創製2020
- Author(s)
  横尾英知，大岡伸通，内藤幹彦，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 国際調和に向けた日本薬局方の医薬品各条における試験法の改定に関する検討：qNMRを利用した類縁物質の純度決定2020
- Author(s)
  辻厳一郎，伊藤貴仁，内山奈穂子，細江潤子，合田幸広，出水庸介
- Organizer
  第2回日本定量ＮＭＲ研究会年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Temperature-dependent formation of N-nitrosodimethylamine (NDMA) during the storage of ranitidine reagent powders and tablets2020
- Author(s)
  Abe Y., Yamamoto, E., Yoshida, Masada, S., Yokoo, H., Tsuji, G., Uchiyama, N., Hakamatsuka, T., Demizu, Y., Izutsu, K., Goda, Y., Okuda, H.
- Organizer
  AAPS 2020 PHARMSCI 360
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Carbocyclic-2'-deoxynucleosideの合成研究－carbocyclic-2'-deoxy-7-deazaadenosineの合成－2020
- Author(s)
  水石彩菜，斎藤智亜季，目黒公太郎，植松明星，原島利彰，林宏典，児玉栄一，三澤隆史，出水庸介，栗原正明，紺野奇重
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 中分子ペプチド医薬品開発に向けた規制上の課題と取組2020
- Author(s)
  出水庸介
- Organizer
  第10回レギュラトリーサイエンス学会学術大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 抗アデノウイルス活性を期待した炭素環2’-デオキシ炭素環7-デアザアデノシンの合成2020
- Author(s)
  今田敦之，水石彩菜，紺野奇重，三澤隆史，出水庸介，栗原正明，藤井幹雄
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ペプチド核酸によるdouble duplex invasionを応用した目視判定可能な一塩基多型検出系の検討2020
- Author(s)
  森谷俊介、笹祐子、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史、杉山　亨
- Organizer
  日本薬学会第１４０年会
- Data Source
  KAKENHI-PROJECT-18K06557
[Presentation] STINGを標的としたCDN誘導体の設計と合成2020
- Author(s)
  栁瀨雄太，池田健太郎，辻厳一郎，柴田識人，内藤幹彦，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of antimicrobial peptide foldamers based on Magainin 2 sequence2020
- Author(s)
  平野元春，後藤千尋，三澤隆史，出水庸介
- Organizer
  第57回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ステープル構造を持つ抗菌ペプチドフォルダマーの開発2020
- Author(s)
  平野元春，後藤千尋，林克彦，菊池裕，三澤隆史，工藤由起子，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 中分子ペプチド医薬品開発に向けた規制上の課題と取組2020
- Author(s)
  出水庸介
- Organizer
  第10回レギュラトリーサイエンス学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 発がん因子BCR-ABLの脱ユビキチン化は慢性骨髄性白血病細胞の増殖に必要である2020
- Author(s)
  柴田識人，大岡伸通，辻厳一郎，出水庸介，内藤幹彦
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 疎水性タグを利用したCRABP分解誘導剤の開発2020
- Author(s)
  正田卓司，大岡伸通，辻厳一郎，井上英史，内藤幹彦，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ステープル構造を持つ抗菌ペプチドフォルダマーの開発2020
- Author(s)
  平野元春，後藤千尋，林克彦，菊池裕，三澤隆史，工藤由起子，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] アミン骨格を利用した環状ジヌクレオチド誘導体の合成とバイオフィルム形成阻害評価2020
- Author(s)
  池田健太郎，栁瀨雄太，辻厳一郎，林克彦，菊池裕，工藤（原）由起子，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 抗アデノウイルス活性を期待した炭素環2’-デオキシ炭素環ピリミジンヌクレオシドの合成2020
- Author(s)
  石綱遥，斎藤智亜季，紺野奇重，三澤隆史，出水庸介，栗原正明，藤井幹雄
- Organizer
  第64回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of peptide-based degraders against estrogen and androgen receptor2020
- Author(s)
  横尾英知，大岡伸通，内藤幹彦，井上貴雄，出水庸介
- Organizer
  第57回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 中分子ペプチド医薬品の非臨床安全性評価における留意点2020
- Author(s)
  斎藤嘉朗，出水庸介
- Organizer
  第10回レギュラトリーサイエンス学会学術大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] アミン構造を基盤とした環状ジヌクレオチド等価体の創製2019
- Author(s)
  栁瀨雄太，池田健太郎，辻厳一郎，林克彦，菊池裕，工藤由起子，出水庸介
- Organizer
  第45回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Peptide foldamers in drug discovery2019
- Author(s)
  Demizu Y, Goto C, Misawa T, Tsuji G.
- Organizer
  26th American Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] マガイニン2配列を基にした安定化ヘリカルペプチドの開発2019
- Author(s)
  後藤千尋，平野元春，林克彦，菊池裕，工藤由起子，三澤隆史，出水庸介
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 新しいユビキチンリガーゼを利用して標的タンパク質を分解するキメラ化合物の開発2019
- Author(s)
  大岡伸通、辻厳一郎、正田卓司、藤里卓磨、栗原正明、出水庸介、内藤幹彦
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] An approach toward visual detection of single nucleotide polymorphism using pseudocomplementary peptide nucleic acid2019
- Author(s)
  森谷俊介，笹祐子，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史，杉山亨
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of amphipathic cell-penetrating foldamers for delivery of biomacromolecules2019
- Author(s)
  Misawa T, Ohoka N, Goto C, Oba M, Tanaka M, Naito M, Demizu Y.
- Organizer
  European Symposium on Organic Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 7-Aminomethyl-7-deazaguanineをもつPNAオリゴマー2019
- Author(s)
  森谷俊介，柴崎初音，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
- Organizer
  第45回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] siRNAを高効率で細胞内に導入する細胞膜透過性ペプチドフォルダマーの開発2019
- Author(s)
  大岡伸通，三澤隆史，内藤幹彦，出水庸介
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of cell-penetrating foldamers for delivery of biomacromolecules2019
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] ヘリカルテンプレートペプチドの合成とpost-modificationによる機能化2019
- Author(s)
  三澤隆史，出水庸介
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 芳香族複素環を有するエストロゲン受容体アンタゴニストの構造活性相関研究2019
- Author(s)
  永沼美弥子，横尾英知，三澤隆史，松野研司，辻厳一郎，出水庸介
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 細胞膜高透過性ペプチドフォルダマーの開発とDDSキャリアへの応用2019
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第13回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 二次構造制御を基盤としたペプチド創薬研究2019
- Author(s)
  出水庸介
- Organizer
  有機合成化学協会九州山口支部講演会「合成有機化学のフロンティア」
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 生体高分子を効率的に細胞内へ輸送する細胞膜高透過性フォルダマーの開発2019
- Author(s)
  三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  ケミカルバイオロジー第14回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 二次構造制御を基盤としたペプチド創薬研究2019
- Author(s)
  出水庸介
- Organizer
  有機合成化学協会九州山口支部講演会「合成有機化学のフロンティア」
- Invited
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ヘリカル構造に着目した抗菌ペプチドの開発とその毒性評価に関する研究2019
- Author(s)
  後藤千尋，三澤隆史，菊池裕，出水庸介
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 創薬研究および違法薬物の規制におけるインシリコ技術の活用2019
- Author(s)
  出水庸介
- Organizer
  MOEフォーラム2019
- Invited
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 新規カチオン性グアニンアナログをもつPNAオリゴマー2019
- Author(s)
  森谷俊介、柴崎初音、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史、杉山　亨
- Organizer
  日本薬学会第１３９年会
- Data Source
  KAKENHI-PROJECT-18K06557
[Presentation] 強い抗菌活性を示す両親媒性ペプチドフォルダマーの開発2019
- Author(s)
  後藤千尋，平野元春，林克彦，三澤隆史，菊池裕，出水庸介
- Organizer
  第13回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ペプチドフォルダマー創薬研究2019
- Author(s)
  出水庸介
- Organizer
  日本薬学会第139回年会シンポジウム:フォルダマーの魅力-新たな創薬への可能性-
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] ペプチドフォルダマー創薬研究2019
- Author(s)
  出水庸介
- Organizer
  日本薬学会第139回年会シンポジウム：フォルダマーの魅力-新たな創薬への可能性-
- Invited
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 中分子ペプチド医薬品開発に向けた規制上の課題と取組2019
- Author(s)
  出水庸介
- Organizer
  第4回レギュラトリーサイエンス公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 7-Aminomethyl-7-deazaguanineをもつPNAの合成2019
- Author(s)
  森谷俊介、柴崎初音、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史、杉山　亨
- Organizer
  第４５回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06557
[Presentation] イオンモビリティー質量分析計を用いた生体試料中フェンタニル類スクリーニング分析法の検討2019
- Author(s)
  河村麻衣子，辻厳一郎，三澤隆史，出水庸介，袴塚高志，花尻瑠理
- Organizer
  日本法中毒学会第38年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 非天然型アミノ酸の開発と含有ペプチドの二次構造制御2019
- Author(s)
  出水庸介
- Organizer
  CMC+AndTech FORUM特殊ペプチドの合成技術と創薬の最新動向
- Invited
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 創薬研究および違法薬物の規制におけるインシリコ技術の活用2019
- Author(s)
  出水庸介
- Organizer
  MOEフォーラム2019
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] 強い抗菌活性を示す両親媒性ペプチドフォルダマーの開発2019
- Author(s)
  後藤千尋，平野元春，林克彦，三澤隆史，菊池裕，出水庸介
- Organizer
  第13回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] フェンタニル類似化合物の化学合成に関する研究2019
- Author(s)
  辻厳一郎，三澤隆史，河村麻衣子，花尻瑠理，袴塚高志，出水庸介
- Organizer
  第56回全国衛生科学技術協議会年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 細胞膜高透過性ペプチドフォルダマーの開発とDDSキャリアへの応用2019
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第13回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] An approach toward visual detection of single nucleotide polymorphism using pseudocomplementary peptide nucleic acid2019
- Author(s)
  Shun-suke Moriya, Yuko Sasa, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Atsushi Kittaka, and Toru Sugiyama
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-18K06557
[Presentation] HPLCによる高血圧治療薬バルサルタン中N-nitrosodimethylamine (NDMA)の迅速定量法2019
- Author(s)
  内山奈穂子，政田さやか，辻厳一郎，新井玲子，出水庸介，袴塚高志，堤智昭，穐山浩，阿部康弘，伊豆津健一，合田幸広，奥田晴宏
- Organizer
  第86回日本分析化学会有機微量分析研究懇談会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 医薬品に混入する懸念のあるN-nitrosodimethylamine(NDMA)の迅速分析法の開発2019
- Author(s)
  政田さやか, 辻厳一郎, 新井玲子, 内山奈穂子, 出水庸介, 袴塚高志, 堤智明, 穐山浩, 阿部康弘, 原矢佑樹, 伊豆津健一, 合田幸広, 奥田晴宏
- Organizer
  第56回全国衛生科学技術協議会年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of small molecule chimeras that recruit aryl-hydrocarbon receptor (AhR) E3 ligase to induce degradation of target proteins2019
- Author(s)
  Ohoka, N., Tsuji, G., Shoda, T., Fujisato, T., Kurihara, M., Demizu, Y., Naito, M.
- Organizer
  AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Peptide foldamers in drug discovery2019
- Author(s)
  Demizu, Y., Goto, C., Misawa, T., Tsuji, G.
- Organizer
  26th American Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 中分子ペプチド医薬品の開発効率化に資するレギュラトリーサイエンス研究2019
- Author(s)
  出水庸介
- Organizer
  2019年度衛研シンポジウム
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] Peptide foldamers in drug discovery2019
- Author(s)
  Tsuji, G., Misawa, T., Demizu, Y.
- Organizer
  27th French-Japanese Symposium on Medicinal and Fine Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 分析用標品確保のためのフェンタニル構造類似化合物の合成に関する研究2019
- Author(s)
  辻厳一郎，三澤隆史，河村麻衣子，花尻瑠理，袴塚高志，出水庸介
- Organizer
  日本法中毒学会第38年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] M7(R2):「潜在的発がんリスクを低減するための医薬品中DNA反応性(変異原性)不純物の評価及び管理」に対する補遺2019
- Author(s)
  出水庸介
- Organizer
  第40回ICH即時報告会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of antimicrobial peptide foldamers based on Magainin 2 sequence2019
- Author(s)
  後藤千尋，平野元春，林克彦，三澤隆史，菊池裕，出水庸介
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of antimicrobial peptide foldamers based on Magainin 2 sequence2019
- Author(s)
  後藤千尋，平野元春，林克彦，三澤隆史，菊池裕，出水庸介
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 二次構造制御を基盤としたペプチド創薬研究2019
- Author(s)
  出水庸介
- Organizer
  第1回新学術「ケモユビキチン」班会議・第2回ユビキチン研究会合同会議
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Design and synthesis of 4-(2-pyrrolyl)-4-phenylheptane derivatives as estrogen receptor ligands2019
- Author(s)
  Tsuji, G., Naganuma, M., Yokoo, H., Misawa, T., Matsuno, K., Demizu, Y.
- Organizer
  17th Annual Discovery on TARGET
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 新しいユビキチンリガーゼをリクルートして標的蛋白質を分解するキメラ化合物の開発と抗がん剤としての可能性2019
- Author(s)
  大岡伸通，辻厳一郎，正田卓司，藤里卓磨，出水庸介，内藤幹彦
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ヘリカル構造制御に基づく抗菌ペプチドフォルダマーの開発2019
- Author(s)
  平野元春，後藤千尋，林克彦，三澤隆史，菊池裕，工藤由起子，出水庸介
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 新規環状ジヌクレオチド誘導体の合成とバイオフィルム形成阻害能の評価2019
- Author(s)
  池田健太郎，栁瀨雄太，辻厳一郎，林克彦，菊池裕，工藤由起子，出水庸介
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of peptide foldamers changing their secondary structures in response to the environmental milieu2019
- Author(s)
  Oba, M., Furukawa, K., Nonaka, H., Demizu, Y., Tanaka, M.
- Organizer
  26th American Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 二次構造制御を基盤としたペプチド創薬研究2019
- Author(s)
  出水庸介
- Organizer
  有機合成化学協会九州山口支部講演会
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] ヘリカル構造制御に基づく抗菌ペプチドフォルダマーの開発2019
- Author(s)
  平野元春，後藤千尋，林克彦，三澤隆史，菊池裕，工藤由起子，出水庸介
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of amphipathic cell-penetrating foldamers for delivery of biomacromolecules2019
- Author(s)
  Misawa, T., Ohoka, N., Goto, C., Oba, M., Tanaka, M., Naito, M., Demizu, Y.
- Organizer
  European Symposium on Organic Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 中分子ペプチド医薬品開発に向けた規制上の課題と取組2019
- Author(s)
  出水庸介
- Organizer
  中分子ペプチド医薬品開発に向けた規制上の課題と取組
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of cell-penetrating foldamers for delivery of biomacromolecules2019
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 創薬研究および違法薬物の規制におけるインシリコ技術の活用2019
- Author(s)
  出水庸介
- Organizer
  MOEフォーラム2019
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 新規カチオン性グアニンアナログをもつPNAオリゴマー2019
- Author(s)
  森谷俊介，柴崎初音，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史，杉山亨
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Peptide foldamers in drug discovery2019
- Author(s)
  Tsuji G, Misawa T, Demizu Y.
- Organizer
  27th French-Japanese Symposium on Medicinal and Fine Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] アミロイドβを創薬標的としたシリビニン誘導体の開発2019
- Author(s)
  水野美麗，森一憲，三澤隆史，高木孝士，出水庸介，柴沼質子，福原潔
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 生体高分子を細胞内に効率的に輸送するキャリアペプチドの開発2019
- Author(s)
  三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] マガイニン2配列を基にした安定化ヘリカルペプチドの開発2019
- Author(s)
  後藤千尋，平野元春，林克彦，菊池裕，工藤由起子，三澤隆史，出水庸介
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 生体高分子を効率的に細胞内へ輸送する細胞膜高透過性フォルダマーの開発2019
- Author(s)
  三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  ケミカルバイオロジー第14回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Synthesis of alpha-exo-methylene ketones from alpha,alpha-disubstituted allyl alcohols by electrochemical oxidative migration2019
- Author(s)
  Yamamoto, K., Kikuchi, N., Hamamizu, T., Yoshimatsu, H., Kuriyama, M., Demizu, Y., Onomura, O.
- Organizer
  The 4th International Symposium on Process Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 生体高分子を細胞内に導入するキャリアペプチドの開発2019
- Author(s)
  三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 生体分子を細胞内に輸送する細胞膜透過性ペプチドフォルダマーの開発2019
- Author(s)
  三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] アミン骨格を基盤とした環状ジヌクレオチド等価体の合成とバイオフィルム形成阻害能の評価2019
- Author(s)
  池田健太郎，栁瀨雄太，辻厳一郎，林克彦，菊池裕，出水庸介
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 生体分子を細胞内に輸送する細胞膜透過性ペプチドフォルダマーの開発2019
- Author(s)
  三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 芳香族/複素環骨格を有するエストロゲン受容体調整薬の創製2019
- Author(s)
  永沼美弥子，三澤隆史，辻厳一郎，横尾英知，松野研司，出水庸介
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] バイオフィルム測定によるMycoplasma pneumoniaeに対する抗菌成分のスクリーニング系の構築2019
- Author(s)
  林克彦，三澤隆史，後藤千尋，出水庸介，工藤由起子，菊池裕
- Organizer
  第46回日本マイコプラズマ学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 生体高分子を細胞内に効率的に輸送するキャリアペプチドの開発2019
- Author(s)
  三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] LC-CDを用いた危険ドラッグMethylphenidate類似体のキラル分析2018
- Author(s)
  河村麻衣子，三澤隆史，出水庸介，花尻瑠理，袴塚高志
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 二次構造制御を基軸とした細胞膜高透過性ペプチドの開発2018
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第50回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Peptide foldamers in drug discovery2018
- Author(s)
  Demizu, Y., Misawa, T., Tsuji, G.
- Organizer
  Bordeaux 2018 Symposium on Foldamers
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] タンパク質の寿命を制御できる分子の開発2018
- Author(s)
  出水庸介
- Organizer
  生体分子コバレント修飾の革新的解析拠点形成シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] タンパク質の寿命を制御できる分子の開発2018
- Author(s)
  出水庸介
- Organizer
  生体分子コバレント修飾の革新的解析拠点形成シンポジウム(招待講演)
- Invited
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] キラルな3員環状アミノ酸の合成と含有ペプチドのコンフォメーション解析2018
- Author(s)
  古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 側鎖上にのみ不斉中心を持つ環状ジ置換アミノ酸よりなるヘリカルペプチドの巻き方制御2018
- Author(s)
  江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，田中正一
- Organizer
  第16回次世代を担う有機化学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 二次構造制御を基盤とした膜透過性ペプチドの開発と核酸デリバリーへの応用2018
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] PNA oligomers possessing PreQ1 as a cationic analogue of guanine2018
- Author(s)
  Sugiyama, T., Shibasaki, H., Moriya, S., Kuwata, K., Imamura, Y., Demizu, Y., Kurihara, M., Kittaka, T.
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Post-modificationによる官能基修飾可能なα,α-ジ置換アミノ酸の設計と合成2018
- Author(s)
  出水庸介，三澤隆史，辻厳一郎
- Organizer
  第48回複素環化学討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 核酸デリバリーを指向した細胞膜高透過性ペプチドフォルダマーの開発2018
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第12回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 液体クロマトグラフィー／多段階質量分析を利用した特殊環状ペプチドの構造解析2018
- Author(s)
  橋井則貴，三澤隆史，鈴木琢雄，出水庸介，石井明子
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 側鎖上にキラルなアセタールを有する環状ジ置換アミノ酸よりなるペプチドの二次構造解析2018
- Author(s)
  江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，田中正一
- Organizer
  第48回複素環化学討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ペプチドリガンドを利用した標的タンパク質分解誘導剤の開発2018
- Author(s)
  出水庸介，三澤隆史，大岡伸通，服部隆行，内藤幹彦
- Organizer
  第44回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 種々の側鎖官能基を有する環状α,α-ジ置換アミノ酸の合成と含有ペプチドの機能評価2018
- Author(s)
  辻厳一郎，小林寛幸，三澤隆史，木下恵愛，松野研司，出水庸介
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 種々の側鎖官能基を有する環状α,α-ジ置換アミノ酸の合成と含有ペプチドの機能評価2018
- Author(s)
  辻厳一郎，小林寛幸，三澤隆史，木下恵愛，松野研司，出水庸介
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 正電荷を帯びたグアニン誘導体をもつPNAオリゴマーの合成2018
- Author(s)
  杉山　亨、柴崎初音、森谷俊介、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史
- Organizer
  第３６回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18K06557
[Presentation] 正電荷を帯びたグアニン誘導体を持つPNAオリゴマーの合成2018
- Author(s)
  杉山亨，柴崎初音，森谷俊介，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of helix-stabilized amphipathic cell-penetrating peptides for siRNA delivery2018
- Author(s)
  Misawa, T., Ohoka, N., Oba, M., Tanaka, M., Naito, M., Demizu, Y.
- Organizer
  35th European Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Low pH-responsive cyclic alpha,alpha-disubstituted alpha-amino acids for controlling secondary structures of peptide foldamers2018
- Author(s)
  Oba, M., Furukawa, K., Toyama, K., Opiyo, G. O., Demizu, Y., Kurihara, M., Doi, M., Tanaka, M.
- Organizer
  Bordeaux 2018 Symposium on Foldamers
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Post-modificationによる官能基修飾可能なα,α-ジ置換アミノ酸の設計と合成2018
- Author(s)
  辻厳一郎，三澤隆史，出水庸介
- Organizer
  ケミカルバイオロジー第13回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Post-modification による官能基修飾可能なα,α-ジ置換アミノ酸の設計と合成2018
- Author(s)
  出水庸介，三澤隆史，辻厳一郎
- Organizer
  第 48 回複素環化学討論会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 側鎖にキラルなアセタールを有する4員環状ジ置換アミノ酸よりなるペプチドのヘリックス二次構造2018
- Author(s)
  江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，田中正一
- Organizer
  第28回福岡万有シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 側鎖上にキラルなアセタールを有する4員環状ジ置換アミノ酸よりなるペプチドの二次構造解析2018
- Author(s)
  江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，宇久翼，田中正一
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] グアニンPNAモノマーの新規カチオン性アナログ2018
- Author(s)
  杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Helical secondary structures of peptides composed of cyclic amino acids with a chiral acetal moiety2018
- Author(s)
  Eto, R., Oba, M., Ueda, A., Doi, M., Demizu, Y., Kurihara, M., Tanaka, M.
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 細胞膜高透過性ペプチドフォルダマーの開発と核酸デリバリーへの応用2018
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 核酸医薬を細胞内に導入するオリゴペプチドの開発2018
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  ケミカルバイオロジー第13回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 側鎖上にキラルなアセタールを有する4員環状ジ置換アミノ酸よりなるペプチドの二次構造解析2018
- Author(s)
  江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，宇久翼，田中正一
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 多様な官能基修飾を志向したヘリカルテンプレートペプチドの開発2018
- Author(s)
  三澤隆史，諫田泰成，出水庸介
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Peptide foldamers in drug discovery2018
- Author(s)
  Demizu, Y., Misawa, T., Tsuji, G.
- Organizer
  Bordeaux 2018 Symposium on Foldamers
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] LC-CDを用いた危険ドラッグMethylphenidate類似体のキラル分析2018
- Author(s)
  河村麻衣子，三澤隆史，出水庸介，花尻瑠理，袴塚高志
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] グアニンPNAモノマーの新規カチオン性アナログ2018
- Author(s)
  杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 多様な官能基修飾を志向したヘリカルテンプレートペプチドの開発2018
- Author(s)
  三澤隆史，諫田泰成，出水庸介
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 細胞膜高透過性ペプチドフォルダマーの開発と核酸デリバリーへの応用2018
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] キラルな3員環状アミノ酸の合成と含有ペプチドのコンフォメーション解析2018
- Author(s)
  古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
- Organizer
  日本薬学会第138回年会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ペプチドリガンドを利用した標的タンパク質分解誘導剤の開発2018
- Author(s)
  出水庸介，三澤隆史，大岡伸通，服部隆行，内藤幹彦
- Organizer
  第 44 回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of cell-penetrating peptide foldamers for siRNA delivery2018
- Author(s)
  Misawa, T., Ohoka, N., Oba, M., Tanaka, M., Naito, M., Demizu, Y.
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] PNA Oligomers Possessing PreQ1 as a Cationic Analogue of Guanine2018
- Author(s)
  Toru Sugiyama, Hatsune Shibasaki, Shun-suke Moriya, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, and Atsushi Kittaka
- Organizer
  10th International Peptide Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06557
[Presentation] 正電荷を帯びたグアニン誘導体をもつPNAの合成2017
- Author(s)
  杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] キラルな三員環状ジ置換アミノ酸とそのペプチドの合成2017
- Author(s)
  古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，栗原正明，田中正一
- Organizer
  第54回化学関連支部合同九州大会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] カチオン性プロリン誘導体を導入した細胞膜透過性ペプチドの開発2017
- Author(s)
  小林寛幸，三澤隆史，内藤幹彦，出水庸介
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of helical cell penetrating peptides using non-proteinogenic amino acids2017
- Author(s)
  Yamashita, H., Misawa, M., Kurihara, M., Demizu, Y.
- Organizer
  Lindau Nobel Laureate Meetings 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] カチオン性プロリン誘導体を導入した細胞膜透過性ペプチドの開発2017
- Author(s)
  小林寛幸，三澤隆史，内藤幹彦，出水庸介
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Post-modification可能なα,α-ジ置換アミノ酸の合成と含有ペプチドの二次構造解析2017
- Author(s)
  小林寛幸，三澤隆史，松野研司，出水庸介
- Organizer
  第43回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 小員環状ジ置換アミノ酸を用いたヘリカル二次構造の制御に関する研究2017
- Author(s)
  古場百合恵，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] カチオン性プロリン誘導体を含む細胞膜透過性ペプチドの開発2017
- Author(s)
  小林寛幸，三澤隆史，松野研司，出水庸介
- Organizer
  第49回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ヘリカルペプチドを用いたビタミンD受容体(VDR)―コアクチベータ相互作用阻害剤の創製2017
- Author(s)
  三澤隆史，出水庸介，栗原正明
- Organizer
  日本ビタミン学会第69回大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 二次構造に着目したカチオン性膜透過ペプチドの創製研究2017
- Author(s)
  小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Peptide foldamers changing their conformations in response to low pH trigger2017
- Author(s)
  古川かほり，大庭誠，遠山琴美，George Ouma Opiyo，出水庸介，栗原正明，土井光暢，田中正一
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] カチオン性プロリン誘導体を含む細胞膜透過性ペプチドの開発2017
- Author(s)
  小林寛幸，三澤隆史，松野研司，出水庸介
- Organizer
  第49回若手ペプチド夏の勉強会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ユビキチンープロテアソーム系を介したHisタグタンパク質分解誘導分子の開発2017
- Author(s)
  沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
- Organizer
  日本薬学会第136年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] ジフェニルメタンを基本骨格とするリガンドの創製2017
- Author(s)
  栗原正明，三澤隆史，出水庸介
- Organizer
  第3回Neo Vitamin D Workshop
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 二次構造に着目したカチオン性膜透過ペプチドの創製研究2017
- Author(s)
  小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] カチオン性プロリン誘導体を含む細胞膜高透過性ペプチドの開発2017
- Author(s)
  小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
- Organizer
  第47回複素環化学討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 低pHに応答して二次構造を変化させるペプチドフォルダマーの開発2017
- Author(s)
  大庭誠，古川かほり，遠山琴美，George Ouma Opiyo，出水庸介，栗原正明，土井光暢，田中正一
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017
- Author(s)
  大岡伸通，正田卓司，藤里卓磨，柴田識人，服部隆行，栗原正明，出水庸介，内藤幹彦
- Organizer
  2017年度生命科学系学会合同年次大会(ConBio2017)
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ジフェニルメタンを基本骨格とするリガンドの創製2017
- Author(s)
  栗原正明，三澤隆史，出水庸介
- Organizer
  第3回Neo Vitamin D Workshop
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 側鎖上にのみ不斉中心を持つ4員環状アミノ酸よりなるペプチドのヘリックス二次構造2017
- Author(s)
  江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，宇久翼，田中正一
- Organizer
  第43回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] カチオン性プロリン誘導体を含む細胞膜高透過性ペプチドの開発2017
- Author(s)
  小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
- Organizer
  第47回複素環化学討論会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 低pHに応答して二次構造を変化させるペプチドフォルダマーの開発2017
- Author(s)
  大庭誠，古川かほり，遠山琴美，George Ouma Opiyo，出水庸介，栗原正明，土井光暢，田中正一
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 多様な生理活性付与を志向した安定化ヘリカルテンプレートペプチドの開発2017
- Author(s)
  三澤隆史，出水庸介
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 親水性分子の細胞内導入を志向した細胞膜高透過性ペプチドの開発2017
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，栗原正明，出水庸介
- Organizer
  第15回次世代を担う有機化学シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of post functionalizable oligopeptides as helical templates2017
- Author(s)
  三澤隆史，出水庸介
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 小員環状ジ置換アミノ酸を用いたヘリカル二次構造の制御に関する研究2017
- Author(s)
  古場百合恵，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of post functionalizable oligopeptides as helical templates2017
- Author(s)
  三澤隆史，出水庸介
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of cationic cell-penetrating peptides focused on their secondary structures2017
- Author(s)
  小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Peptide foldamers changing their conformations in response to low pH trigger2017
- Author(s)
  古川かほり，大庭誠，遠山琴美，George Ouma Opiyo，出水庸介，栗原正明，土井光暢，田中正一
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 二次構造制御を基盤とした膜透過性ペプチドの開発2017
- Author(s)
  三澤隆史，小林寛幸，大庭誠，田中正一，栗原正明，出水庸介
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 側鎖上にのみ不斉中心を持つ4員環状アミノ酸よりなるペプチドのヘリックス二次構造2017
- Author(s)
  江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，宇久翼，田中正一
- Organizer
  第43回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 二次構造制御に基づくペプチド創薬研究2017
- Author(s)
  出水庸介，三澤隆史，栗原正明
- Organizer
  第43回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Hisタグ融合タンパク質分解誘導分子の設計と合成2017
- Author(s)
  沖津航陽，服部隆行，三澤隆史，栗原正明，内藤幹彦，出水庸介
- Organizer
  ケミカルバイオロジー第12回年会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Development of helical cell penetrating peptides using non-proteinogenic amino acids2017
- Author(s)
  Yamashita, H., Misawa, M., Kurihara, M., Demizu, Y.
- Organizer
  Lindau Nobel Laureate Meetings 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 側鎖に不斉中心を有する三員環状ジ置換アミノ酸とそのペプチドの合成2017
- Author(s)
  池田光生，古場百合恵，上田篤志，大庭誠，出水庸介，栗原正明，田中正一
- Organizer
  第34回日本薬学会九州支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 二次構造制御に基づくペプチド創薬研究2017
- Author(s)
  出水庸介，三澤隆史，栗原正明
- Organizer
  第43回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 親水性分子の細胞内導入を志向した細胞膜高透過性ペプチドの開発2017
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，栗原正明，出水庸介
- Organizer
  第15回次世代を担う有機化学シンポジウム
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 正電荷を帯びたグアニン誘導体をもつPNAの合成2017
- Author(s)
  杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Hisタグ融合タンパク質分解誘導分子の設計と合成2017
- Author(s)
  沖津航陽，服部隆行，三澤隆史，栗原正明，内藤幹彦，出水庸介
- Organizer
  ケミカルバイオロジー第12回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] コンピュータシミュレーションによる違法薬物の活性予測に関する研究2017
- Author(s)
  出水庸介，田中理恵，袴塚高志，栗原正明，花尻瑠理
- Organizer
  日本法中毒学会第36回年会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] コンピュータシミュレーションによる違法薬物の活性予測に関する研究2017
- Author(s)
  出水庸介，田中理恵，袴塚高志，栗原正明，花尻瑠理
- Organizer
  日本法中毒学会第36回年会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Synthesis of chiral three-membered ring α,α-disubstituted α-amino acid and conformational analysis of its peptides2017
- Author(s)
  古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] キラルな三員環状ジ置換アミノ酸とそのペプチドの合成2017
- Author(s)
  古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，栗原正明，田中正一
- Organizer
  第54回化学関連支部合同九州大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Development of cationic cell-penetrating peptides focused on their secondary structures2017
- Author(s)
  小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017
- Author(s)
  大岡伸通，正田卓司，藤里卓磨，柴田識人，服部隆行，栗原正明，出水庸介，内藤幹彦
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] Post-modification可能なα,α-ジ置換アミノ酸の合成と含有ペプチドの二次構造解析2017
- Author(s)
  小林寛幸，三澤隆史，松野研司，出水庸介
- Organizer
  第43回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 側鎖に不斉中心を有する三員環状ジ置換アミノ酸とそのペプチドの合成2017
- Author(s)
  池田光生，古場百合恵，上田篤志，大庭誠，出水庸介，栗原正明，田中正一
- Organizer
  第34回日本薬学会九州支部大会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017
- Author(s)
  大岡伸通，正田卓司，藤里卓磨，柴田識人，服部隆行，栗原正明，出水庸介，内藤幹彦
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017
- Author(s)
  大岡伸通，正田卓司，藤里卓磨，柴田識人，服部隆行，栗原正明，出水庸介，内藤幹彦
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Synthesis of chiral three-membered ring α,α-disubstituted α-amino acid and conformational analysis of its peptides2017
- Author(s)
  古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Peptide nucleic acid possessing PreQ1 as a cationic analogue of guanine2017
- Author(s)
  杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] 二次構造制御を基盤とした膜透過性ペプチドの開発2017
- Author(s)
  三澤隆史，小林寛幸，大庭誠，田中正一，栗原正明，出水庸介
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Peptide nucleic acid possessing PreQ1 as a cationic analogue of guanine2017
- Author(s)
  杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
- Organizer
  第54回ペプチド討論会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ヘリカルペプチドを用いたビタミンD受容体(VDR)―コアクチベータ相互作用阻害剤の創製2017
- Author(s)
  三澤隆史，出水庸介，栗原正明
- Organizer
  日本ビタミン学会第69回大会
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 多様な生理活性付与を志向した安定化ヘリカルテンプレートペプチドの開発2017
- Author(s)
  三澤隆史，出水庸介
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-17K08385
[Presentation] ペプチド二次構造制御に基づく細胞膜高透過性ペプチドの開発2016
- Author(s)
  出水庸介，山下博子，三澤隆史，大庭誠，田中正一，栗原正明
- Organizer
  第14回次世代を担う有機化学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] エチレンアセタールを有するキラル5員環アミノ酸を含有するペプチドのヘリカル二次構造2016
- Author(s)
  古場百合恵，上田篤志，大庭誠，土井光暢，出水庸介，栗原正明，田中正一
- Organizer
  日本薬学会第136回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] エストロゲン受容体分解誘導ペプチドの創製2016
- Author(s)
  出水庸介，大岡伸通，三澤隆史，内藤幹彦，栗原正明
- Organizer
  日本薬学会第136回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ペプチド二次構造制御に基づく細胞膜高透過性ペプチドの創製2016
- Author(s)
  出水庸介，山下博子，加藤巧馬，大岡伸通，三澤隆史，服部隆行，田中正一，内藤幹彦，大庭誠，栗原正明
- Organizer
  ケミカルバイオロジー第11回年会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Development of helix-stabilized cell-penetrating peptides as an intracellular delivery tool2016
- Author(s)
  Demizu, Y., Yamashita, H., Misawa, T., Oba, M., Tanaka, M., Kurihara, M.
- Organizer
  34th European Peptide Symposium & 8th International Peptide Symposium
- Place of Presentation
  Germany
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 二次構造制御を基軸とした膜透過ペプチドの創製研究2016
- Author(s)
  出水庸介，三澤隆史，山下博子，大庭誠，田中正一，内藤幹彦，栗原正明
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Hisタグタンパク質分解誘導分子の開発2016
- Author(s)
  沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
- Organizer
  日本薬学会第136回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] エストロゲン受容体分解活性を有するラロキシフェン誘導体の開発2016
- Author(s)
  正田卓司，加藤雅士，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
- Organizer
  日本薬学会第136回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 環境応答型二次構造変化を利用した細胞膜高透過性ペプチドの開発2016
- Author(s)
  山下博子，出水庸介，加藤巧馬，大岡伸通，三澤隆史，服部隆行，田中正一，内藤幹彦，大庭誠，栗原正明
- Organizer
  日本薬学会第136回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 核内受容体を標的とした転写活性化阻害および分解誘導ペプチドの開2016
- Author(s)
  出水庸介
- Organizer
  第48回若手ペプチド夏の勉強会
- Place of Presentation
  東京
- Year and Date
  2016-07-31
- Invited
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] デアザグアニン誘導体を持つPNAの合成2016
- Author(s)
  杉山亨，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
- Organizer
  日本薬学会第136回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Hisタグ融合タンパク質分解誘導分子の開発2016
- Author(s)
  出水庸介，沖津航陽，服部隆行，三澤隆史，内藤幹彦，栗原正明
- Organizer
  第42回反応と合成の進歩シンポジウム
- Place of Presentation
  静岡
- Year and Date
  2016-11-07
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 二次構造制御に基づく抗菌ペプチドフォルダマーの開発2016
- Author(s)
  小澤佑斗，出水庸介，三澤隆史，菊池裕，栗原正明
- Organizer
  日本薬学会第136回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Protein knockdown by SNIPER compounds: Application for basic research and cancer therapy2016
- Author(s)
  Naito, M., Hattori, T., Ohoka, N., Shibata, N., Shoda, T., Demizu, Y., Kurihara, M.
- Organizer
  The 10th AACR-JCA Joint Conference
- Place of Presentation
  Hawaii
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ヘリカルプロモーター導入によるオリゴアルギニンの構造制御と膜透過能への効果2016
- Author(s)
  三澤隆史，山下博子，加藤巧馬，服部隆行，大庭誠，田中正一，内藤幹彦，出水庸介，栗原正明
- Organizer
  日本薬学会第136回年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 側鎖にグアニジノ基を有するプロリン誘導体の合成と細胞膜透過性ペプチドへの応用2016
- Author(s)
  出水庸介，小林寛幸，山下博子，三澤隆史，大庭誠，田中正一，松野研司，栗原正明
- Organizer
  第46回複素環化学討論会
- Place of Presentation
  金沢
- Year and Date
  2016-09-26
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Structure-activity relationship analysis of short helical peptides as VDR-coactivator interaction inhibitors2015
- Author(s)
  Misawa, T., Demizu, Y., Kurihara, M.
- Organizer
  第43回構造活性相関シンポジウム，第10回薬物の分子設計と開発に関する日中シンポジウム
- Place of Presentation
  新潟
- Year and Date
  2015-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ヘリカルペプチドを用いたビタミンD受容体（VDR）-コアクチベータ相互作用阻害剤の創製2015
- Author(s)
  三澤隆史，出水庸介，栗原正明
- Organizer
  ケミカルバイオロジー第10回年会
- Place of Presentation
  宮城
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ジフェニルメタンを基本骨格としたエストロゲン受容体転写阻害剤および分解誘導剤の開発2015
- Author(s)
  依岡桃子，三澤隆史，出水庸介，大岡伸通，槇島誠，南雲紳史，内藤幹彦，栗原正明
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  千葉
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ジフェニルメタンを基本骨格とするエストロゲン受容体アンタゴニストの創製2015
- Author(s)
  田中克哉，三澤隆史，出水庸介，諫田泰成，槇島誠，関野祐子，内藤幹彦，栗原正明
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  千葉
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] エストロゲン受容体を標的とした転写活性化阻害および分解誘導ペプチドの創製2015
- Author(s)
  出水庸介，三澤隆史，諫田泰成，大岡伸通，関野祐子，内藤幹彦，栗原正明
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] アルギニン含有ペプチドの細胞膜透過性とpDNAデリバリーに関する研究2015
- Author(s)
  大庭誠，古川かほり，加藤巧馬，山下博子，出水庸介，栗原正明，田中正一
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 血管新生促進作用を有する新規2-クロル炭素環オキセタノシンA（COA-Cl）誘導体の創製2015
- Author(s)
  榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ノンセコステロイド型VDRリガンドによるATRA耐性急性前骨髄球性白血病細胞の分化誘導2015
- Author(s)
  野尻久雄，村田拓哉，橘高敦史，出水庸介，三澤隆史，栗原正明
- Organizer
  第36回日本臨床薬理学会学術総会
- Place of Presentation
  東京
- Year and Date
  2015-12-09
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Development of His-tag fused protein degradation inducer based on protein knockdown strategy2015
- Author(s)
  沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  神奈川
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Development of helix-stabilized cationic peptides with cell-membrane penetrating ability2015
- Author(s)
  山下博子，出水庸介，三澤隆史，服部隆行，大庭誠，田中正一，内藤幹彦，栗原正明
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  神奈川
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Development of stabilized helical peptides and their functionalization2015
- Author(s)
  Demizu, Y., Misawa, T., Kurihara, M.
- Organizer
  13th International Kyoto Conference on New Aspects of Organic Chemistry
- Place of Presentation
  京都
- Year and Date
  2015-11-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] コンピュータシミュレーションによる合成カンナビノイドのCB1受容体への結合様式解析2015
- Author(s)
  出水庸介，三澤隆史，内山奈穂子，花尻瑠理，袴塚高志，栗原正明
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  千葉
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 新規トリアジン誘導体の合成とそれらの抗HIV-1活性評価2015
- Author(s)
  榊原紀和，Gianfranco Balboni，Cenzo Congiu，Valentina Onnis，出水庸介，三澤隆史，栗原正明，加藤善久，丸山徳見，外山政明，岡本実佳，馬場昌範
- Organizer
  ケミカルバイオロジー第10回年会
- Place of Presentation
  宮城
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ノンセコステロイド型VDRリガンドの創製2015
- Author(s)
  三澤隆史，出水庸介，槇島誠，栗原正明
- Organizer
  第1回Neo Vitamin D Workshop
- Place of Presentation
  滋賀
- Year and Date
  2015-08-28
- Invited
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Development of cell-penetrating fragment conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription2015
- Author(s)
  Demizu, Y., Misawa, T., Kanda, Y., Sekino, Y., Kurihara, M.
- Organizer
  The 11th Australian Peptide Conference 2015
- Place of Presentation
  Australia
- Year and Date
  2015-10-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] エストロゲン受容体転写阻害剤および分解誘導剤の創製2015
- Author(s)
  依岡桃子，三澤隆史，出水庸介，大岡伸通，諫田泰成，槇島誠，南雲紳史，関野祐子，内藤幹彦，栗原正明
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Development of helical peptide as inhibitors of estrogen receptor-mediated transcription2015
- Author(s)
  出水庸介，三澤隆史，諫田泰成，大岡伸通，関野祐子，内藤幹彦，栗原正明
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  神奈川
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 長鎖アルキルを有するノンセコステロイド型VDRリガンドの創製2015
- Author(s)
  三澤隆史，依岡桃子，出水庸介，大岡伸通，木下恵愛，槇島誠，内藤幹彦，栗原正明
- Organizer
  第41回反応と合成の進歩シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Hisタグタンパク質応答性蛍光プローブの開発2015
- Author(s)
  沖津航陽，出水庸介，三澤隆史，正田卓司，服部隆行，内藤幹彦，栗原正明
- Organizer
  ケミカルバイオロジー第10回年会
- Place of Presentation
  宮城
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Estrogen induces proliferation of breast cancer stem cells via NO/sGC/cGMP signaling pathway2015
- Author(s)
  Hirata, N.; Demizu, Y.; Kurihara, M.; Sekino, Y.; Kanda, Y.
- Organizer
  第13回幹細胞シンポジウム
- Place of Presentation
  東京
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Design and synthesis of short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors2015
- Author(s)
  三澤隆史，出水庸介，栗原正明
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  神奈川
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors2015
- Author(s)
  Misawa, T., Demizu, Y., Kurihara, M.
- Organizer
  PACIFICHEM 2015
- Place of Presentation
  Hawaii
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] エストロゲンによるNOを介した乳癌幹細胞の増殖2015
- Author(s)
  平田尚也，山田茂，出水庸介，栗原正明，関野祐子，諫田泰成
- Organizer
  第132回日本薬理学会関東部会
- Place of Presentation
  千葉
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ラロキシフェン骨格を有する新規エストロゲン受容体分解誘導剤の開発2015
- Author(s)
  正田卓司，加藤雅士，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 血管新生促進剤を指向した2-クロル炭素環オキセタノシンA（COA-Cl）の新規誘導体の創製研究2015
- Author(s)
  榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
- Organizer
  第54回薬学会中国四国支部学術大会
- Place of Presentation
  高知
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] エストロゲン受容体転写活性化阻害能を有するヘリカルペプチドの開発2015
- Author(s)
  出水庸介，三澤隆史，長久保貴哉，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
- Organizer
  ケミカルバイオロジー第10回年会
- Place of Presentation
  宮城
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 修飾デアザグアニン含有PNAオリゴマーの合成2015
- Author(s)
  杉山亨，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] グアニジノ基を有する環状アミノ酸の合成と細胞膜透過性ペプチドへの応用2015
- Author(s)
  出水庸介，山下博子，三澤隆史，大庭誠，田中正一，栗原正明
- Organizer
  第45回複素環化学討論会
- Place of Presentation
  東京
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] DDSキャリアを指向したカチオン性非天然アミノ酸導入ペプチドの開発2015
- Author(s)
  山下博子，出水庸介，三澤隆史，大庭誠，田中正一，服部隆行，内藤幹彦，栗原正明
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 細胞膜透過性の向上を指向したカチオン性アミノ酸の合成およびその応用2015
- Author(s)
  山下博子，出水庸介，三澤隆史，服部隆行，大庭誠，田中正一，内藤幹彦，栗原正明
- Organizer
  第41回反応と合成の進歩シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Design, synthesis and evaluation of tamoxifen derivatives as new selective estrogen receptor down-regulators2015
- Author(s)
  Shoda, T., Kato, M., Okuhira, K., Demizu, Y., Inoue, H., Naito, M., Kurihara, M.
- Organizer
  PACIFICHEM 2015
- Place of Presentation
  Hawaii
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 長鎖アルキル基を有するビタミンD受容体リガンドの創製2015
- Author(s)
  三澤隆史，依岡桃子，出水庸介，大岡伸通，木下恵愛，槇島誠，内藤幹彦，栗原正明
- Organizer
  第59回日本薬学会関東支部大会
- Place of Presentation
  千葉
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ノンセコステロイド型ビタミンD受容体リガンドの創製―官能基変換による活性制御―2015
- Author(s)
  三澤隆史，依岡桃子，出水庸介，谷内出友美，大岡伸通，木下恵愛，野尻久雄，橘高敦史，槇島誠，内藤幹彦，栗原正明
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  千葉
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Cell-penetrating ability and plasmid DNA delivary using fluorescein-labeled arginine-rich peptides2015
- Author(s)
  Oba, M., Furukawa, K., Kato, T., Demizu, Y., Yamashita, H., Kurihara, M., Tanaka, M.
- Organizer
  The 11th Australian Peptide Conference 2015
- Place of Presentation
  Australia
- Year and Date
  2015-10-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Synthesis of PNA oligomers containing modified deazaguanines for the development of functional PNA2015
- Author(s)
  杉山亨，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  神奈川
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Conformational analysis of peptides composed of chiral cyclic amino acids2015
- Author(s)
  古場百合恵，上田篤志，大庭誠，土井光暢，出水庸介，栗原正明，田中正一
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  神奈川
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 2-クロル炭素環オキセタノシンA (COA-Cl)の新規誘導体の合成とその血管新生促進作用2015
- Author(s)
  榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
- Organizer
  第45回複素環化学討論会
- Place of Presentation
  東京
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 細胞内Hisタグタンパク質応答性蛍光プローブの開発2014
- Author(s)
  沖津航陽，出水庸介，三澤隆史，正田卓司，服部隆行，内藤幹彦，栗原正明
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] エストロゲン受容体分解誘導剤による乳癌の細胞死誘導分子機構2014
- Author(s)
  奥平桂一郎，出水庸介，服部隆行，大岡伸通，柴田識人，最上（西巻）知子，栗原正明，奥田晴宏，内藤幹彦
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-25430164
[Presentation] エストロゲン受容体転写阻害ペプチドの創製2014
- Author(s)
  長久保貴哉，出水庸介，佐藤由紀子，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市
- Data Source
  KAKENHI-PROJECT-25430164
[Presentation] Bestatin/tamoxifen hybrid molecule induces proteasomal degradation of estrogen receptor a and necrotic cell death in breast cancer cells2014
- Author(s)
  Okuhira K, Demizu Y, Ohoka N, Shibata N, Hattori T, Nishimaki-Mogami T, Kurihara M, Okuda H, Naito M
- Organizer
  Keystone Symposia on Molecular and Cellular Biology, The Ubiquitin System: From Basic Science to Drug Discovery
- Place of Presentation
  米国ビッグスカイ
- Data Source
  KAKENHI-PROJECT-25430164
[Presentation] エストロゲン受容体転写阻害能を有するペプチドの創製2014
- Author(s)
  長久保貴哉，出水庸介，三澤隆史，佐藤由紀子，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 合成カンナビノイドのCB1受容体に対する結合様式解析に関する研究2014
- Author(s)
  出水庸介，三澤隆史，内山奈穂子，花尻瑠理，袴塚高志，栗原正明
- Organizer
  第58回日本薬学会関東支部大会
- Place of Presentation
  東京
- Year and Date
  2014-10-04
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] LXXLL モチーフを有する安定化ヘリカルペプチド2013
- Author(s)
  白川真奈美,名児耶早織,出水庸介,正田卓司,佐藤由紀子,栗原正明
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] らせん構造を有する新規フォルダマーの創製2013
- Author(s)
  山崎徳和,出水庸介,正田卓司,佐藤由紀子,栗原正明
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] SNIPER induces ubiquitylation and proteasomal degradation of estrogen receptor followed by rapid cell death in breast cancer cells2013
- Author(s)
  Okuhira K, Demizu Y, Ohoka N, Shibata N, Hattori T, Nishimaki-Mogami T, Kurihara M, Okuda H, Naito M
- Organizer
  The 35th Naito Conference; The Ubiquitin-Proteasome System
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-25430164
[Presentation] 安定化ヘリカルペプチドを用いたVDR-コアクチベータ結合阻害剤の創製2013
- Author(s)
  名児耶早織,出水庸介,佐藤由紀子,正田卓司,土井光暢,田中正一,栗原正明
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells2013
- Author(s)
  Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Nishimaki-Mogami, T, Okuda H, Kurihara M, Naito M
- Organizer
  AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  米国ボストン
- Data Source
  KAKENHI-PROJECT-25430164
[Presentation] ジ置換アミノ酸によるLD-ペプチドの二次構造制御2013
- Author(s)
  出水庸介,土井光暢,佐藤由紀子,田中正一,栗原正明
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] 安定化ヘリカルペプチドを用いたビタミンD 受容体転写阻害剤の創製2012
- Author(s)
  名児耶早織,出水庸介,山縣奈々子,佐藤由紀子,土井光暢,田中正一,栗原正明
- Organizer
  日本薬学会第132 年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] 安定化ヘリカルペプチドを用いたVDR 転写阻害剤の設計と合成2012
- Author(s)
  名児耶早織,出水庸介,佐藤由紀子,土井光暢,田中正一,栗原正明
- Organizer
  日本ケミカルバイオロジー学会第7回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] 安定化ヘリカルペプチドを用いたα,β-不飽和ケトンの不斉エポキシ化2011
- Author(s)
  出水庸介,名児耶早織,佐藤由紀子,奥田晴宏,栗原正明,土井光暢,田中正一
- Organizer
  第37回反応と合成の進歩シンポジウム
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Design of Stabilized α-Helical Peptides for Transcriptional Inhibitor of Nuclear Receptor2011
- Author(s)
  S. Nagoya, Y. Demizu, Y. Sato, M. Doi, M. Tanaka, H. Okuda, M. Kurihara
- Organizer
  AIMECS11
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Design of a stabilized helical peptides and its application2011
- Author(s)
  M. Kurihara, Y. Demizu, N. Yamagata, Y. Sato, Y. Takeuchi, M. Doi, M. Tanaka, H. Okuda
- Organizer
  22nd American peptide symposium
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] ヘリカルペプチドの制御とカルコン類の不斉エポキシ化への応用2011
- Author(s)
  出水庸介,山縣奈々子,佐藤由紀子,土井光暢,田中正一,奥田晴宏,栗原正明
- Organizer
  日本薬学会第131 年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Design of non-secosteroidal VDR ligands and binding mode to VDR-LBD2011
- Author(s)
 Y.Demizu
- Organizer
 4^<th> European Conference on Chemisitry for Life Sciences
- Place of Presentation
 Budapest, Hungary
- Data Source
 KAKENHI-PROJECT-22590114
[Presentation] ノンセコ型VDRリガンドの創製およびVDRとの相互作用解析2011
- Author(s)
  出水庸介
- Organizer
  日本ケミカルバイオロジー学会第6回年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Controlling helical peptides containing equal numbers of L- and D-amino acids2011
- Author(s)
 Y.Demizu
- Organizer
 22^<nd> American peptide symposium
- Place of Presentation
 San Diego
- Data Source
 KAKENHI-PROJECT-22590114
[Presentation] ステープルペプチドを用いたα,β-不飽和ケトンの不斉エポキシ化2011
- Author(s)
  出水庸介
- Organizer
  第55回日本薬学会関東支部大会
- Place of Presentation
  千葉
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] ヘリカルペプチドの制御とカルコン類の不斉エポキシ化への応用2011
- Author(s)
  出水庸介, 山縣奈々子, 佐藤由紀子, 土井光暢, 田中正一, 奥田晴宏, 栗原正明
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] Design of Stapled Helical Peptides for Catalyic Eenantioselective Epoxidation of α,α-Unsaturated Ketones2011
- Author(s)
  出水庸介
- Organizer
  第48回ペプチド討論会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Controlling the helical screw sense of Aib-based peptides with chiral α-amino acids2010
- Author(s)
  Y.Demizu
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  ハワイ
- Year and Date
  2010-12-18
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] Controlling the helical screw sense of Aib-based peptides with chiral a-amino acids2010
- Author(s)
  Demizu, Y., Sato, Y., Tanaka, M, Doi, M, Suemune, H, Okuda, H, Kurihara, M
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] ヘリカルオリゴマーによるα,β-不飽和ケトンの不斉エポキシ化2010
- Author(s)
  出水庸介, 田中正一
- Organizer
  「協奏機能触媒」第7回公開シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] Development of non-secosteroidal VDR ligands2010
- Author(s)
  Demizu, Y, Sato, Y, Ochiai, E, Horie, K, Kakua, S, Takimoto-Kamimura, M, Okuda, H, Kurihara, M
- Organizer
  The 21st French-Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] Structural control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences2010
- Author(s)
  Y.Demizu
- Organizer
  31st European Peptide Symposium
- Place of Presentation
  デンマーク
- Year and Date
  2010-09-07
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] Conformational studies of diastereomeric-Leu-Aib-peptides2010
- Author(s)
  Demizu, Y., Doi, M., Sato, Y., Tanaka, M., Okuda, H., Kurihara, M
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] Conformational studies of diastereomeric -Leu-Aib- peptides2010
- Author(s)
  Y.Demizu
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  京都
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] Conformational studies of diastereomeric-Leu-Aib-peptides2010
- Author(s)
  Y.Demizu
- Organizer
  5th International Peptide Symposium
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] Structural control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences2010
- Author(s)
  Demizu, Y, Doi, M, Sato, Y, Tanaka, M, Okuda, H Kurihara, M
- Organizer
  31st European Peptide Symposium
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] Development of non-secosteroidal VDR ligands2010
- Author(s)
  Y.Demizu
- Organizer
  The 21st French-Japanese Symposium on Medicinal and Fine Chemistry
- Place of Presentation
  京都
- Year and Date
  2010-05-10
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] C末端バリンによるヘリカル二次構造の制御2010
- Author(s)
  出水庸介
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] ノンセコVDRリガンドの創製と結合様式の解析2010
- Author(s)
  出水庸介
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] 新たな水素結合ネットワークを指向したVDRリガンド2010
- Author(s)
  出水庸介, 佐藤由紀子, 竹内由起, 落合鋭士, 堀江恭平, 角田真二, 上村みどり, 奥田晴宏, 栗原正明
- Organizer
  日本ケミカルバイオロジー学会第5回年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] ノンセコVDRリガンドの創製と結合様式の解析2010
- Author(s)
  出水庸介, 佐藤由紀子, 落合鋭士, 堀江恭平, 高木健一郎, 角田真二, 上村みどり, 奥田晴宏, 栗原正明
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] C末端バリンによるヘリカル二次構造の制御2010
- Author(s)
  出水庸介
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  岡山桃太郎アリーナ(岡山)
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] C末端バリンによるヘリカル二次構造の制御2010
- Author(s)
  出水庸介, 佐藤由紀子, 土井光暢, 田中正一, 奥田晴宏, 栗原正明
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] Structural control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences2010
- Author(s)
  Y.Demizu
- Organizer
  31'st European Peptide Symposium
- Place of Presentation
  Copenhagen
- Data Source
  KAKENHI-PROJECT-22590114
[Presentation] 新たな水素結合ネットワークを指向したVDRリガンド2010
- Author(s)
  出水庸介
- Organizer
  日本ケミカルバイオロジー学会第5回年会
- Place of Presentation
  東京
- Year and Date
  2010-05-18
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] 水溶性キラル環状α,α-ジ置換アミノ酸およびペプチドの合成とコンフォメーション解析2009
- Author(s)
  出水庸介
- Organizer
  第46回ペプチド討論会
- Place of Presentation
  北九州国際会議場(福岡)
- Year and Date
  2009-11-04
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] ノンセコステロイド型VDRリガンドのデノボ設計2009
- Author(s)
  出水庸介, 金子文也, 岩井すみれ, 高橋健男, 佐藤由紀子, 落合鋭士, 堀江恭平, 角田真二, 上村みどり, 奥田晴宏, 栗原正明
- Organizer
  第35回反応と合成の進歩シンポジウム
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] ノンセコステロイド型VDRリガンドの設計と合成2009
- Author(s)
  出水庸介
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京大学(東京)
- Year and Date
  2009-11-25
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] 水溶性キラル環状α,α-ジ置換アミノ酸およびペプチドの合成とコンフォメーション解析2009
- Author(s)
  出水庸介, 田中正一, 末宗洋, 土井光暢, 佐藤由紀子, 奥田晴宏, 栗原正明
- Organizer
  第46回ペプチド討論会
- Place of Presentation
  北九州
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] ノンセコステロイド型VDRリガンドのデノボ設計2009
- Author(s)
  出水庸介
- Organizer
  第35回反応と合成の進歩シンポジウム
- Place of Presentation
  金沢市文化ホール(石川)
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] ノンセコステロイド型VDRリガンドの設計と合成2009
- Author(s)
  出水庸介, 金子文也, 岩井すみれ, 高橋健男, 佐藤由紀子, 落合鋭士, 堀江恭平, 角田真二, 上村みどり, 奥田晴宏, 栗原正明
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21790018
[Presentation] Chiral azabicyclo-N-oxyls and asymmetric oxidation of secondary alcohols mediated by them2008
- Author(s)
  Demizu, Y.; Shiigi, H.; Mori, H.; Matsumoto, K.; Matsumura, Y.; Onomura, O
- Organizer
  213th ECS Meeting
- Place of Presentation
  Phoenix
- Data Source
  KAKENHI-PROJECT-19790017
[Presentation] Chiral azabicyclo-N-oxyls and asymmetric oxidation of secondary alcohols mediated by them2008
- Author(s)
  Demizu, Y. et al.
- Organizer
  The 213th ECS Meeting
- Place of Presentation
  Phoenix, USA
- Data Source
  KAKENHI-PROJECT-19790017
[Presentation] 分子認識に基づくアルコール類の不斉トシル化2008
- Author(s)
  出水庸介, ,満田勝, 松本和也, 松村功啓, 尾野村治
- Organizer
  日本薬学会第128年会
- Data Source
  KAKENHI-PROJECT-19790017
[Presentation] 新規キラルN-オキシルを用いる二級アルコールの不斉電極酸化2007
- Author(s)
  出水庸介
- Organizer
  第31回有機電子移動化学討論会
- Place of Presentation
  鳥取
- Year and Date
  2007-06-14
- Data Source
  KAKENHI-PROJECT-19790017
[Presentation] Electrochemical oxidation of alcohols catalyzed by new organic mediators2007
- Author(s)
  Demizu, Y.
- Organizer
  211th ECS Meeting
- Place of Presentation
  アメリカ
- Year and Date
  2007-05-11
- Data Source
  KAKENHI-PROJECT-19790017
[Presentation] 新規キラルN-オキシンを用いる二級アルコールの不斉電極酸化2007
- Author(s)
  出水庸介, 末続肇, 尾野村治, 松村功啓
- Organizer
  第31回有機電子移動化学討論会
- Place of Presentation
  鳥取
- Data Source
  KAKENHI-PROJECT-19790017
[Presentation] 分子認識に基づくキラル銅触媒を用いたアルコール類の不斉トシル化2007
- Author(s)
  出水庸介
- Organizer
  第1回若手交流合宿セミナー
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19790017
[Presentation] 分子認識に基づくアルコール類の不斉トシル化2007
- Author(s)
  出水庸介
- Organizer
  日本薬学会第128年会
- Place of Presentation
  横浜
- Year and Date
  2007-03-26
- Data Source
  KAKENHI-PROJECT-19790017
[Presentation] Electrochemical oxidation of alcohols catalyzed by new organic mediators2007
- Author(s)
  Demizu, Y.; Oda, T.; Onomura, O.; Matsumura, Y
- Organizer
  211th ECS Meeting
- Place of Presentation
  Chicago
- Data Source
  KAKENHI-PROJECT-19790017
[Presentation] Synthesis and conformational analysis of helical oligomers with a changeable chiral acetal moiety
- Author(s)
  江藤諒，大庭誠，上田篤志，石川奈保子，栗原正明，出水庸介，末宗洋，土井光暢，田中正一
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] HIV-1剤を指向した1-置換型ウラシル誘導体および尿素誘導体の創製研究
- Author(s)
  榊原紀和，馬場昌範，岡本実佳，外山政明，出水庸介，三澤隆史，栗原正明，入江晃司，加藤善久，丸山徳見
- Organizer
  第52回薬学会中国四国支部学術大会
- Place of Presentation
  愛媛
- Year and Date
  2014-10-26 – 2014-10-27
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 三重螺旋構造の安定化を指向したβ-ペプチド導入型コラーゲン模倣物の創製
- Author(s)
  杖本望，出水庸介，百合野翔太郎，中村陽菜，土井麻緒，栗原正明，須原義智
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 抗ウィルス薬を目指した新規O-硫酸化多糖類の合成
- Author(s)
  岡崎優祐，出水庸介，細谷翼，川口潤一郎，栗原正明，須原義智
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 3,5-ジメチルベンジル基を有するウラシル誘導体および尿素誘導体の合成とそれらの抗HIV-1活性評価
- Author(s)
  榊原紀和，馬場昌範，岡本実佳，外山政明，出水庸介，三澤隆史，栗原正明，入江晃司，加藤善久，丸山徳見
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Helical secondary structures of peptides having chiral cyclic amino acid with two azido functional groups
- Author(s)
  Tanaka, M., Takazaki, H., Kawabe, N., Doi, M., Demizu, Y., Kurihara, M., Suemune, H., Oba, M.
- Organizer
  33rd European Peptide Symposium
- Place of Presentation
  ブルガリア
- Year and Date
  2014-08-31 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] VDR-コアクチベータ結語阻害作用を有するステープルペプチドの創製
- Author(s)
  川村愛，出水庸介，三澤隆史，栗原正明
- Organizer
  ケミカルバイオロジー第9回年会
- Place of Presentation
  大阪
- Year and Date
  2014-06-12 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] エストロゲン受容体転写阻害ペプチドの開発
- Author(s)
  出水庸介，長久保貴哉，三澤隆史，佐藤由紀子，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
- Organizer
  第40回反応と合成の進歩シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ヘリカルペプチドを用いたエストロゲン受容体転写阻害剤の創製
- Author(s)
  三澤隆史，長久保貴哉，出水庸介，佐藤由紀子，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 細胞内タンパク質に対する蛍光スイッチング機能を持つ小分子プローブの開発
- Author(s)
  沖津航陽，出水庸介，三澤隆史，正田卓司，服部隆行，内藤幹彦，栗原正明
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 二次構造制御に基づく膜透過性ヘリカルペプチドの創製
- Author(s)
  山下博子，出水庸介，三澤隆史，大庭誠，田中正一，栗原正明
- Organizer
  第40回反応と合成の進歩シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] エストロゲン受容体転写活性化阻害ペプチドの創製
- Author(s)
  出水庸介，長久保貴哉，三澤隆史，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Stapled short helical peptides for vitamin D receptor-coactivator interaction inhibitor
- Author(s)
  Kurihara, M., Kawamura, M., Misawa, T., Sato, Y., Demizu, Y.
- Organizer
  33rd European Peptide Symposium
- Place of Presentation
  ブルガリア
- Year and Date
  2014-08-31 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Conformations of LD-peptides containing equal amounts of L-amino acids, D-amino acids, and achiral α,α-disubstitued amino acids
- Author(s)
  Demizu, Y., Misawa, T., Yamashita, H., Doi, M., Sato, Y., Tanaka, M., Kurihara
- Organizer
  33rd European Peptide Symposium
- Place of Presentation
  ブルガリア
- Year and Date
  2014-08-31 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] リパーゼ触媒を用いた[5]ヘリセン類の速度論的光学分割
- Author(s)
  清水貴士，山本耕介，メイビョウ，出水庸介，栗原正明，末宗洋，臼井一晃
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 二次構造制御に基づくカチオン性膜透過ペプチドの開発
- Author(s)
  山下博子, 出水庸介, 三澤隆史, 服部隆行, 大庭誠, 田中正一, 内藤幹彦, 栗原正明
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 糖アミノ酸を用いた新規糖質類縁体の合成と抗ウィルス薬への応用
- Author(s)
  岡崎優祐，出水庸介，細谷翼，栗原正明，須原義智
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] オリゴアルギニンをベースとした細胞膜透過性ヘリカルペプチドの開発
- Author(s)
  山下博子，出水庸介，三澤隆史，大庭誠，田中正一，栗原正明
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] D-トレイトール由来のアセタールを有する六員環状ジ置換アミノ酸よりなるペプチドのコンフォメーション解析
- Author(s)
  江藤諒，大庭誠，上田篤志，栗原正明，出水庸介，末宗洋，田中正一
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Development of cell-permeable peptide for transcriptional inhibitor of estrogen receptor
- Author(s)
  長久保貴哉，出水庸介，三澤隆史，佐藤由紀子，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Modified Deazaguanies for the synthesis of PNA
- Author(s)
  杉山亨，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 細胞膜高透過性Tatペプチドミミックの開発
- Author(s)
  出水庸介，三澤隆史，山崎徳和，佐藤由紀子，大庭誠，田中正一，栗原正明
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] エストロゲン受容体転写活性化阻害ペプチドの創製
- Author(s)
  出水庸介, 長久保貴哉, 三澤隆史, 諫田泰成, 奥平桂一郎, 関野祐子, 内藤幹彦, 栗原正明
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学（兵庫県・神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-25430164
[Presentation] 生体材料への応用を指向した新規コラーゲン様ペプチドの創製
- Author(s)
  杖本望，出水庸介，百合野翔太郎，小川舞，土井麻緒，中村陽菜，栗原正明，須原義智
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] カンナビノイド受容体調整薬の設計と合成
- Author(s)
  三澤隆史，出水庸介，船田正彦，栗原正明
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] Development of stabilized short helical peptides with cell-membrane penetrating ability
- Author(s)
  山下博子，出水庸介，三澤隆史，大庭誠，田中正一，栗原正明
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島
- Year and Date
  2014-10-22 – 2014-10-24
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 抗HIV-1剤を指向した1-置換型3-(3,5-ジメチルベンジル)ウラシルの創製研究
- Author(s)
  榊原紀和，馬場昌範，岡本実佳，外山政明，出水庸介，栗原正明，入江晃司，加藤善久，丸山徳見
- Organizer
  ケミカルバイオロジー第9回年会
- Place of Presentation
  大阪
- Year and Date
  2014-06-12 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 環状メチオニンの合成とそのペプチドの二次構造解析
- Author(s)
  小野京，島袋充史，上田篤志，大庭誠，土井光暢，出水庸介，栗原正明，田中正一
- Organizer
  第40回反応と合成の進歩シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 非対称ジフェニルメタンを基本骨格とするエストロゲン受容体アンタゴニストの設計と合成
- Author(s)
  田中克哉，依岡桃子，三澤隆史，諫田泰成，関野祐子，出水庸介，栗原正明
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] ヘリカル構造制御に基づく細胞膜高透過性ペプチドの創製
- Author(s)
  出水庸介，三澤隆史，山崎徳和，山下博子，佐藤由紀子，大庭誠，田中正一，栗原正明
- Organizer
  ケミカルバイオロジー第9回年会
- Place of Presentation
  大阪
- Year and Date
  2014-06-12 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] 短鎖ペプチドのヘリカル構造制御と機能化
- Author(s)
  出水庸介
- Organizer
  第51回ペプチド討論会
- Place of Presentation
  徳島
- Year and Date
  2014-10-22 – 2014-10-24
- Invited
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] アセタールを有するキラル環状ジ置換アミノ酸によるヘリカル二次構造の制御
- Author(s)
  古場百合恵，上田篤志，大庭誠，土井光暢，出水庸介，栗原正明，田中正一
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460169
[Presentation] デアザグアニン誘導体を持つPNAモノマーの合成
- Author(s)
  杉山亨，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
- Organizer
  日本薬学会第135回年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460169

1. Naito Mikihiko (00198011)

# of Collaborated Projects: 3 results

# of Collaborated Products: 40 results
2. SUGIYAMA TORU (40242036)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
3. 森谷俊介 (60717544)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
4. 伊藤拓水 (30533179)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
5. KURIHARA Masaaki (20205206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 25 results
6. OKUHIRA Keiichiro (10425671)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. SAEKI Yasushi (80462779)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 大岡伸通 (80568519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. 石川稔 (70526839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 村田茂穂 (20344070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 岩井一宏 (60252459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 深井周也 (10361792)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 岡本晃充 (60314233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 山中聡士 (50853884)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MISAWA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
16. KITTAKA Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
17. DEMIZU Yusuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. OBA Makoto

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. SYODA Takuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
20. 横尾英知

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
21. 柴田識人

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 古武弥一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 秋山泰身

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 田中正一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 末宗洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 尾野村治

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
27. 服部隆行

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
28. 林克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 辻厳一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Demizu Yousuke 出水 庸介

DEMIZU Yosuke 出水 庸介

Research Projects

Research Products

Co-Researchers

Controlling the lifetime of proteins using chemical degradersPrincipal Investigator

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Molecular design and synthesis of pseudo-complementary peptide nucleic acids capable of strand invasion without restriction

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革新的中分子医薬品創出を目指したペプチドフォルダマー研究Principal Investigator

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Design and synthesis of peptide nucleic acids toward overcoming sequence restrictions in strand invasion

Principal Investigator

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Chemical protein knockdown technology and cell regulation

Principal Investigator

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New frontier for ubiquitin biology driven by chemo-technologies

Principal Investigator

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Peptide foldamers in drug discoveryPrincipal Investigator

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Design of peptide ligands based on protein-protein interaction and their application to protein knockdown technology

Principal Investigator

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Development of stabilized helical peptides as POI degradation inducersPrincipal Investigator

Principal Investigator

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Development of estrogen receptor degrader and analysis of drug-induced cell death mechanism for breast cancer therapy

Principal Investigator

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Design of a stabilized short helical peptide and its application

Principal Investigator

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Design of proline analogues based on hybrid methods and their applicationPrincipal Investigator

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Design and synthesis of non-proteinogenic amino acids and peptide foldamers by anodic functionalizatonPrincipal Investigator

Principal Investigator

Project Period (FY)

Demizu Yousuke 出水庸介

DEMIZU Yosuke 出水庸介

[Book] 次世代医薬とバイオ医療　第２章ペプチド医薬およびペプチド様医薬2022