Kobayashi Shigeki 小林茂樹

… Alternative Names

KOBAYASHI Shigeki 小林茂樹

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Researcher Number	90397993
Other IDs
Affiliation (Current)	2025: 山口大学, 医学部, 教授(連携講座)
Affiliation (based on the past Project Information) *help	2021 – 2025: 山口大学, 医学部, 教授(連携講座) 2021: 山口大学, 医学部, 教授 2017 – 2021: 山口大学, 大学院医学系研究科, 准教授 2016: 山口大学, 医学(系)研究科(研究院), 准教授 2013 – 2016: 山口大学, 医学部附属病院, 講師 … More 2007 – 2012: Yamaguchi University, Hospital, Assistant Professor 2010: 山口大学, 医学部・附属病院, 助教 2006: 山口大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Anesthesiology/Resuscitation studies / Cardiovascular medicine Except Principal Investigator Cardiovascular medicine / Circulatory organs internal medicine / Basic Section 53020:Cardiology-related / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator リアノジン受容体 / ダントロレン / 心不全 / 不整脈 / カルシウムハンドリング / 心室頻拍 / 悪性高熱症 / arrhythmia / dantrolene / ryanodine receptor … More / heart failure / 心室頻拍症 / 致死的不整脈致死的不整脈 / 弛緩障害 / 高血圧 / 拡張不全 / internal medicine / 内科 / カテコラミン誘発性心室頻拍 … More Except Principal Investigator リアノジン受容体 / 致死的不整脈 / 心不全 / カルモジュリン / 筋小胞体 / 不整脈 / 心筋症 / 心肥大 / EC coupling / E-C coupling / CPVT / 興奮収縮連関 / カルシウム / 小胞体Ca制御 / スキャホールド / 光干渉断層法 / 不安定プラーク / 心筋梗塞 / 全ゲノム / 空間トランスクリプトーム / メチル化 / 心臓 / 老化 / 全遺伝子解析 / 分泌小胞 / 次世代シーケンス解析 / エクソソーム / ゲノム編集マウス / ゲノム解析 / ゲノム編集 / 遺伝子 / 拡張型心筋症 / ダントロレン / 循環器・高血圧 / 上大静脈隔離術 / 肺静脈隔離術 / 心房リモデリング / カテーテルアブレーション / 心房細動 / リアニジン受容体 / Ca2+ハンドリング / Caハンドリング / ryanodine receptor / calmodulin / K201 / Calmodulin / Ryanodine receptor / EC-coupling / 心室性不整脈 / 分子心臓病態学 / 点突然変異 Less

Development of RyR2-targetting therapy for heart failure and arrhythmiaPrincipal Investigator
- Principal Investigator
  
  小林茂樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
Analysis of genomic DNA in aging heart
- Principal Investigator
  
  水上洋一
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Yamaguchi University
心筋梗塞ハイリスク病変に対する血管小胞体Ca制御による新規プラーク安定化療法の開発
- Principal Investigator
  
  岡村誉之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
リアノジン受容体を分子標的とした心不全・不整脈の新たな治療開発Principal Investigator
- Principal Investigator
  
  小林茂樹
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
Whlole genome analysis in exosome from dilated cardiomyopathy occurred by aging
- Principal Investigator
  
  Mizukami Yoichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Yamaguchi University
Treatment of heart failure, cardiac hypertrophy, and fatal arrhythmia by ryanodine receptor-bound calmodulin regulation
- Principal Investigator
  
  YANO MASAFUMI
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
Targetting ryanodine receptors for anti-heart failure and anti-arrhythmic therapyPrincipal Investigator
- Principal Investigator
  
  Kobayashi Shigeki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
Novel treatment of arrhythmia and heart failure by controlling the domain of ryanodine receptors
- Principal Investigator
  
  Yamamoto Takeshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Yamaguchi University
Comprehensive treatment of heart failure, cardiac hypertrophy, and arrhythmia by controlling ryanodine receptor bound calmodulin
- Principal Investigator
  
  YANO Masafumi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Construction of up-stream therapy for persistent atrial fibrillation originated from non-pulmonary vein/superior vena cava
- Principal Investigator
  
  YOSHIGA Yasuhiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Novel therapy of arrhythmia targeting key domain in ryanodine receptor
- Principal Investigator
  
  YAMAMOTO Takeshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Ryanodine receptor-targeting therapy for heart failure and lethal arrhythmiaPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Shigeki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Comprehensive strategy of heart failure, cardiac hypertrophy and lethal arrhythmia via stabilizing the stricture of ryanodine receptor
- Principal Investigator
  
  YANO Masafumi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Yamaguchi University
Development of comprehensive treatment of heart failure, hypertrophy, and arrhythmia by regulating intracellular Ca
- Principal Investigator
  
  YANO Masafumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
Development of novel arrhythmia therapy using K201 binding core in RyR2 molecle
- Principal Investigator
  
  YAMAMOTO Takeshi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
Innovation of treatment for malignant hyperthermia and arrhythmia by inhibition of abnormal intracellular Ca2+ release through the ryanodine receptorPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI SHIGEKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yamaguchi University
Development of new therapy for heart failure and arrhythmia by correction of signal transduction within cardiac ryanodine receptor
- Principal Investigator
  
  YANO Masafumi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
Novel therapeutic strategy of the fatal arrhythmia targeting specific domain in the ryanodine receptor molecle
- Principal Investigator
  
  YAMAMOTO Takeshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Yamaguchi University
Innovation of treatment for malignant hyperthermia and arrhythmia by inhibition of abnormal intracellular Ca2+ release through the ryanodine receptorPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Shigeki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yamaguchi University
Elucidation of molecular mechanism and treatment for abnormal ryanodine receptor in patients with malignant hyperthermia and lethal arrhythmiaPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Shigeki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology/Resuscitation studies
- Research Institution
  Yamaguchi University

[Book] 循環代謝ー原始・現代・未来ー2020
- Author(s)
  小林茂樹、矢野雅文
- Total Pages
  142
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-18K08039
[Book] Cutting Edge of Molecular Cardiology 新しい臨床を開拓するための分子循環器病学2019
- Author(s)
  小林茂樹
- Total Pages
  210
- Publisher
  南山堂
- ISBN
  9784525249410
- Data Source
  KAKENHI-PROJECT-18K08039
[Book] メディカル・サイエンス・ダイジェスト　心不全 Up to Date2019
- Author(s)
  小林茂樹、矢野雅文
- Total Pages
  57
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-18K08039
[Book] 循環器内科「たこつぼ心筋症」2017
- Author(s)
  小林　茂樹　他
- Total Pages
  108
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-15K09142
[Book] 循環器内科｢心拍数と心機能｣2015
- Author(s)
  小林茂樹、矢野雅文
- Total Pages
  117
- Publisher
  科学論評社
- Data Source
  KAKENHI-PROJECT-15K09142
[Book] 「静注用β１遮断薬ランジオロールを不整脈患者においてどう使うか」不整脈治療　update 第4巻2015
- Author(s)
  小林茂樹
- Total Pages
  224
- Publisher
  医薬ジャーナル
- Data Source
  KAKENHI-PROJECT-15K09142
[Book] 循環器内科｢β受容体制御による心不全治療｣2015
- Author(s)
  小林茂樹、矢野雅文
- Total Pages
  116
- Publisher
  科学論評社
- Data Source
  KAKENHI-PROJECT-15K09142
[Book] β遮断薬を臨床で活かす。2013
- Author(s)
  小林茂樹、矢野雅文
- Total Pages
  172
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23592256
[Book] β遮断薬を使いこなす　-生命予後の改善を目指して-2013
- Author(s)
  小林茂樹、矢野雅文
- Total Pages
  107
- Publisher
  月刊循環器
- Data Source
  KAKENHI-PROJECT-23592256
[Journal Article] Dantrolene, a ryanodine receptor stabilizer, is a candidate immunomodulator for treating rheumatic disease2024
- Author(s)
  Nawata T、Honda T、Sakai H、Tsuji S、Otsuka M、Uchinoumi H、Kobayashi S、Yamamoto T、Asagiri M、Yano M
- Journal Title
  
  Scandinavian Journal of Rheumatology
  
  Volume: 53 Issue: 3 Pages: 217-219
- DOI
  10.1080/03009742.2023.2297519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14444, KAKENHI-PROJECT-21K08128
[Journal Article] Herpud1 modulates hypertrophic signals independently of calmodulin nuclear translocation in rat myocardium-derived H9C2 cells2023
- Author(s)
  Fujioka Riko、Yamamoto Takeshi、Maruta Akihiro、Nakamura Yoshihide、Tominaga Naoomi、Inamitsu Masako、Oda Tetsuro、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 652 Pages: 61-67
- DOI
  10.1016/j.bbrc.2023.02.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-21K08128
[Journal Article] RyR2-stabilization therapy with dantrolene against left ventricular remodeling and lethal arrhythmia in heart failure2023
- Author(s)
  Kobayashi Shigeki、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 182 Pages: 25-27
- DOI
  10.1016/j.yjmcc.2023.07.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-21K08054
[Journal Article] RyR2-targeting therapy prevents left ventricular remodeling and ventricular tachycardia in post-infarction heart failure2023
- Author(s)
  Fujii Shohei、Kobayashi Shigeki、Chang Yaowei、Nawata Junya、Yoshitomi Ryosuke、Tanaka Shinji、Kohno Michiaki、Nakamura Yoshihide、Ishiguchi Hironori、Suetomi Takeshi、Uchinoumi Hitoshi、Oda Tetsuro、Okuda Shinichi、Okamura Takayuki、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 178 Pages: 36-50
- DOI
  10.1016/j.yjmcc.2023.03.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-22K15686
[Journal Article] Stabilizing cardiac ryanodine receptor with dantrolene treatment prevents left ventricular remodeling in pressure-overloaded heart failure mice2023
- Author(s)
  Yano Yasutake、Kobayashi Shigeki、Uchida Tomoyuki、Chang Yaowei、Nawata Junya、Fujii Shohei、Nakamura Yoshihide、Suetomi Takeshi、Uchinoumi Hitoshi、Oda Tetsuro、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 642 Pages: 175-184
- DOI
  10.1016/j.bbrc.2022.12.063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119
[Journal Article] Dantrolene, a Ryr2 Stabilizer, rtestores Impaired Diastolic Function in the Pressure-overloaded Hypertrophied Heart.2023
- Author(s)
  Chang Y, Kobayashi S, Yano Y, Uchida T, Nawata J, Fujii S, Nakamura Y, Suetomi T, Uchinoumi H, oda T, Yamamoto T, Yano M.
- Journal Title
  
  Med.Sci.Innov.
  
  Volume: 70 Pages: 7-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08128
[Journal Article] Dantrolene improves left ventricular diastolic property in mineralcorticoid-salt-induced hypertensive rats2023
- Author(s)
  Nawata Junya、Yamamoto Takeshi、Tanaka Shinji、Yano Yasutake、Uchida Tomoyuki、Fujii Shohei、Nakamura Yoshihide、Suetomi Takeshi、Uchinoumi Hitoshi、Oda Tetsuro、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 34 Pages: 101449-101449
- DOI
  10.1016/j.bbrep.2023.101449
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119, KAKENHI-PROJECT-21K08128
[Journal Article] Dantrolene reduces platelet-derived growth factor (PDGF)-induced vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice2022
- Author(s)
  Sakai Chihiro、Mikawa Mei、Yamamoto Takeshi、Uchida Tomoyuki、Nakamura Yoshihide、Akase Hideaki、Suetomi Takeshi、Tominaga Naoomi、Inamitsu Masako、Oda Tetsuro、Okamura Takayuki、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 623 Pages: 51-58
- DOI
  10.1016/j.bbrc.2022.07.038
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20K17119
[Journal Article] Enhanced oxidative stress and presence of ventricular aneurysm for risk prediction in cardiac sarcoidosis.2022
- Author(s)
  Yoshitomi R, Kobayashi S, Yano Y, Nakashima Y, Fujii S, Nanno T, Ishiguchi H, Fukuda M, Yoshiga Y, Okamura T, Suga K, Kawano R, Yano M.
- Journal Title
  
  Heart
  
  Volume: 108 Issue: 6 Pages: 429-437
- DOI
  10.1136/heartjnl-2021-320244
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-21K08128
[Journal Article] Stabilization of RyR2 maintains right ventricular function, reduces the development of ventricular arrhythmias, and improves prognosis in pulmonary hypertension.2022
- Author(s)
  Tanaka S, Yamamoto T, Mikawa M, Nawata J, Fujii S, Nakamura Y, Kato T, Fukuda M, Suetomi T, Uchinoumi H, Oda T, Okuda S, Okamura T, Kobayashi S, Yano M.
- Journal Title
  
  Heart Rhythm.
  
  Volume: S1547 Issue: 6 Pages: 00119-00119
- DOI
  10.1016/j.hrthm.2022.02.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-20K17119
[Journal Article] Stabilizing Tetrameric Structure of Ryanodine Receptor Cures Lethal Arrhythmia in Heart Failure2022
- Author(s)
  Kobayashi Shigeki、Yamamoto Takeshi、Yoshiga Yasuhiro、Okamura Takayuki、Kawano Reo、Yano Masafumi
- Journal Title
  
  Circulation: Arrhythmia and Electrophysiology
  
  Volume: 15 Issue: 10 Pages: 714-717
- DOI
  10.1161/circep.122.011220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-20H03677
[Journal Article] Dantrolene, a stabilizer of the ryanodine receptor, prevents collagen-induced arthritis.2022
- Author(s)
  58)Nawata T, Sakai H, Honda T, Otsuka M, Fujita H, Uchinoumi H, Kobayashi S, Yamamoto T, Asagiri M, Yano M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 624 Pages: 141-145
- DOI
  10.1016/j.bbrc.2022.07.111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06803, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-20H03677
[Journal Article] Herpud1 suppress angiotensin II induced hypertrophy in cardiomyocytes.2022
- Author(s)
  Mikawa M, Sakai C, Yamamoto T, Nakamura Y, Tanaka S, Tominaga N, Inamitsu M, Oda T, Kobayashi S, Yano M.
- Journal Title
  
  Biochem Biophys Rep.
  
  Volume: 30 Pages: 101248-101248
- DOI
  10.1016/j.bbrep.2022.101248
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128
[Journal Article] Endoplasmic reticulum stress promotes nuclear translocation of calmodulin, which activates phenotypic switching of vascular smooth muscle cells2022
- Author(s)
  Uchida Tomoyuki、Oda Tetsuro、Yamamoto Takeshi、Inamitsu Masako、Sakai Chihiro、Uchinoumi Hitoshi、Suetomi Takeshi、Nakamura Yoshihide、Okamoto Yoko、Tateda Satomi、Fujii Shohei、Tanaka Shinji、Nawata Junya、Okamura Takayuki、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 628 Pages: 155-162
- DOI
  10.1016/j.bbrc.2022.08.069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128, KAKENHI-PROJECT-22K15686, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20K17119
[Journal Article] Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease2021
- Author(s)
  Nakamura Yoshihide、Yamamoto Takeshi、Xu Xiaojuan、Kobayashi Shigeki、Tanaka Shinji、Tamitani Masaki、Saito Takashi、Saido Takaomi C.、Yano Masafumi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 7289-7289
- DOI
  10.1038/s41598-021-86822-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-21K08054, KAKENHI-PROJECT-21K08128
[Journal Article] Relation between Oscillometric Measurement of Central Hemodynamics and Left Ventricular Hypertrophy in Hypertensive Patients2021
- Author(s)
  Obayashi Masakazu、Kobayashi Shigeki、Nanno Takuma、Hamada Yoriomi、Yano Masafumi
- Journal Title
  
  Pulse
  
  Volume: 9 Issue: 3-4 Pages: 116-124
- DOI
  10.1159/000520006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08128
[Journal Article] Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca2+/calmodulin-dependent protein kinase IIδc transgenic mice2020
- Author(s)
  Sufu-Shimizu Yoko、Okuda Shinichi、Kato Takayoshi、Nishimura Shigehiko、Uchinoumi Hitoshi、Oda Tetsuro、Kobayashi Shigeki、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 2 Pages: 431-438
- DOI
  10.1016/j.bbrc.2020.01.107
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-18K08039
[Journal Article] Dantrolene prevents ventricular tachycardia by stabilizing the ryanodine receptor in pressure- overload induced failing hearts2020
- Author(s)
  Kajii Toshiro、Kobayashi Shigeki、Shiba Sho、Fujii Shohei、Tamitani Masaki、Kohno Michiaki、Nakamura Yoshihide、Nanno Takuma、Kato Takayoshi、Okuda Shinichi、Uchinoumi Hitoshi、Oda Tetsuro、Yamamoto Takeshi、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 521 Issue: 1 Pages: 57-63
- DOI
  10.1016/j.bbrc.2019.10.071
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178
[Journal Article] G790del mutation in DSC2 alone is insufficient to develop the pathogenesis of ARVC in a mouse model2020
- Author(s)
  Hamada Yoriomi、Yamamoto Takeshi、Nakamura Yoshihide、Sufu-Shimizu Yoko、Nanno Takuma、Fukuda Masakazu、Ono Makoto、Oda Tesuro、Okuda Shinichi、Ueyama Takeshi、Kobayashi Shigeki、Yano Masafumi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 21 Pages: 100711-100711
- DOI
  10.1016/j.bbrep.2019.100711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-18K15890
[Journal Article] Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling2020
- Author(s)
  Kohno Michiaki、Kobayashi Shigeki、Yamamoto Takeshi、Yoshitomi Ryosuke、Kajii Toshiro、Fujii Shohei、Nakamura Yoshihide、Kato Takayoshi、Uchinoumi Hitoshi、Oda Tetsuro、Okuda Shinichi、Watanabe Kenji、Mizukami Yoichi、Yano Masafumi
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 714-714
- DOI
  10.1038/s42003-020-01443-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K11128, KAKENHI-PROJECT-18K16255, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-18K08572, KAKENHI-PROJECT-20H03677
[Journal Article] Dantrolene prevents hepatic steatosis by reducing cytoplasmic Ca 2+ level and ER stress2020
- Author(s)
  Tamitani M, Yamamoto T, Yamamoto N, Fujisawa K, Tanaka S, Nakamura Y, Uchinoumi H, Oda T, Okuda S, Takami T, Kobayashi S, Sakaida I, Yano M.
- Journal Title
  
  Biochem Biophys Rep.
  
  Volume: 23:100787. Pages: 100787-100793
- DOI
  10.1016/j.bbrep.2020.100787
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08005, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-20H03677, KAKENHI-PROJECT-20H03663
[Journal Article] A multicenter, randomized, double-blind, controlled study to evaluate the efficacy and safety of dantrolene on ventricular arrhythmia as well as mortality and morbidity in patients with chronic heart failure (SHO-IN trial): rationale and design2020
- Author(s)
  Kobayashi Shigeki, Yano Masafumi et al.
- Journal Title
  
  Journal of Cardiology
  
  Volume: 75 Issue: 4 Pages: 454-461
- DOI
  10.1016/j.jjcc.2019.08.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08039
[Journal Article] Author's reply: The RyR2 : Targeting therapy against lethal arrhythmia2020
- Author(s)
  Kobayashi Shigeki、Yoshiga Yasuhiro、Yano Masafumi
- Journal Title
  
  Journal of Cardiology
  
  Volume: in press Issue: 3 Pages: 1-2
- DOI
  10.1016/j.jjcc.2020.03.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039
[Journal Article] Addition of a β1-Blocker to Milrinone Treatment Improves Cardiac Function in Patients with Acute Heart Failure and Rapid Atrial Fibrillation2019
- Author(s)
  Kobayashi Shigeki、Myoren Takeki、Kajii Toshiro、Kohno Michiaki、Nanno Takuma、Ishiguchi Hironori、Nishimura Shigehiko、Fukuda Masakazu、Hino Akihiro、Fujimura Tatsuhiro、Ono Makoto、Uchinoumi Hitoshi、Tateishi Hiroki、Mochizuki Mamoru、Oda Tetsuro、Okuda Shinichi、Yoshiga Yasuhiro、Kawano Reo、Yano Masafumi
- Journal Title
  
  Cardiology
  
  Volume: 142 Issue: 4 Pages: 195-202
- DOI
  10.1159/000499400
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-18K15890
[Journal Article] Ryanodine receptor-bound calmodulin is essential to protect against catecholaminergic polymorphic ventricular tachycardia2019
- Author(s)
  Nakamura Yoshihide、Yamamoto Takeshi、Kobayashi Shigeki、Tamitani Masaki、Hamada Yoriomi、Fukui Go、Xu Xiaojuan、Nishimura Shigehiko、Kato Takayoshi、Uchinoumi Hitoshi、Oda Tetsuro、Okuda Shinichi、Yano Masafumi
- Journal Title
  
  JCI Insight
  
  Volume: 4 Issue: 11 Pages: 1-18
- DOI
  10.1172/jci.insight.126112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08108, KAKENHI-PROJECT-17H04178
[Journal Article] Treatment of Class IV Lupus Nephritis with Mycophenolate Mofetil Monotherapy2018
- Author(s)
  Nawata Takashi、Kubo Makoto、Fujii Shohei、Shiragami Kosaku、Ikegami Tadayoshi、Kobayashi Shigeki、Hisano Satoshi、Yano Masafumi
- Journal Title
  
  Intern. Med.
  
  Volume: 57 Issue: 14 Pages: 2067-2070
- DOI
  10.2169/internalmedicine.0304-17
- NAID
  130007404877
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2018-07-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08039
[Journal Article] Change in muscle volume after steroid therapy in patients with myositis assessed using cross-sectional computed tomography.2018
- Author(s)
  Nawata T, Kubo M, Nomura T, Oishi K, Shiragami K, Ikegami T, Okada M, Kobayashi S, Yano M
- Journal Title
  
  BMC Musculoskelet Disord
  
  Volume: 19 Issue: 1 Pages: 93-93
- DOI
  10.1186/s12891-018-2008-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H02110, KAKENHI-PROJECT-18K08039
[Journal Article] Strict sequential catheter ablation strategy targeting the pulmonary veins and superior vena cava for persistent atrial fibrillation2018
- Author(s)
  Yoshiga Y, Shimizu A, Ueyama T, Ono M, Fukuda M, Fumimoto T, Ishiguchi H, Omuro T, Kobayashi S, Yano M.
- Journal Title
  
  Journal of Cardiology
  
  Volume: 71 Pages: 16-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09439
[Journal Article] CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca 2+ release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy2018
- Author(s)
  Okuda Shinichi、Sufu-Shimizu Yoko、Kato Takayoshi、Fukuda Masakazu、Nishimura Shigehiko、Oda Tetsuro、Kobayashi Shigeki、Yamamoto Takeshi、Morimoto Sachio、Yano Masafumi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 496 Issue: 4 Pages: 1250-1256
- DOI
  10.1016/j.bbrc.2018.01.181
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08540, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-16K08514, KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-16K15443
[Journal Article] Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin2018
- Author(s)
  Oda Tetsuro、Yamamoto Takeshi、Kato Takayoshi、Uchinoumi Hitoshi、Fukui Go、Hamada Yoriomi、Nanno Takuma、Ishiguchi Hironori、Nakamura Yoshihide、Okamoto Yoko、Kono Michiaki、Okuda Shinichi、Kobayashi Shigeki、Bers Donald M.、Yano Masafumi
- Journal Title
  
  Journal of Molecular and Cellular Cardiology
  
  Volume: 125 Pages: 87-97
- DOI
  10.1016/j.yjmcc.2018.10.011
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-16K09502, KAKENHI-PROJECT-17H04178
[Journal Article] Strict sequential catheter ablation strategy targeting the pulmonary veins and superior vena cava for persistent atrial fibrillation.2018
- Author(s)
  Yoshiga Y, Shimizu A, Ueyama T, Ono M, Fukuda M, Fumimoto T, Ishiguchi H, Omuro T, Kobayashi S, Yano M.
- Journal Title
  
  J Cardiol
  
  Volume: in press Issue: 2 Pages: 128-134
- DOI
  10.1016/j.jjcc.2018.01.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19409, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-16K15443
[Journal Article] Localized Doxorubicin-Induced Cardiomyopathy Complicated With Shower Emboli Originating From Apical Intramural Thrombi2018
- Author(s)
  Ishiguchi H, Kobayashi S, Okuda S, Okamura T, Okada M, Takemura G, Takahashi M, Mikamo A, Hamano K, Yano M.
- Journal Title
  
  Circ J
  
  Volume: 82 Issue: 9 Pages: 2375-2376
- DOI
  10.1253/circj.CJ-17-1231
- NAID
  130007438912
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2018-08-24
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02110, KAKENHI-PROJECT-18K08039
[Journal Article] Mutation-linked, excessively tight interaction between the calmodulin binding domain and the C-terminal domain of the cardiac ryanodine receptor as a novel cause of catecholaminergic polymorphic ventricular tachycardia.2018
- Author(s)
  Nishimura S, Yamamoto T, Nakamura Y, Kohno M, Hamada Y, Sufu Y, Fukui G, Nanno T, Ishiguchi H, Kato T, Xu X, Ono M, Oda T, Okuda S, Kobayashi S, Yano M.
- Journal Title
  
  Heart Rhythm
  
  Volume: 印刷中 Issue: 6 Pages: 905-914
- DOI
  10.1016/j.hrthm.2018.02.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-16K19409, KAKENHI-PROJECT-18K08039, KAKENHI-PROJECT-18K08076, KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-16K15443
[Journal Article] Urinary 8-Hydroxy-2′-Deoxyguanosine as a Myocardial Oxidative Stress Marker Is Associated With Ventricular Tachycardia in Patients With Active Cardiac Sarcoidosis2017
- Author(s)
  Ishiguchi H, Kobayashi S, Myoren T, Kohno M, Nanno T, Murakami W, Oda S, Oishi K, Okuda S, Okada M, Suga K, Yano M.
- Journal Title
  
  Cardiovascular Imaging,
  
  Volume: 10 Issue: 12
- DOI
  10.1161/circimaging.117.006764
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H02110, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-16K15443
[Journal Article] Correction of impaired calmodulin binding to RyR2 as a novel therapy for lethal arrhythmia in the pressure-overloaded heart failure.2017
- Author(s)
  Kato T, Yamamoto T, Nakamura Y, Nanno T, Fukui G, Sufu Y, Hamada Y, Maeda T, Nishimura S, Ishiguchi H, Murakami W, Fukuda M, Xu X, Hino A, Ono M, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M.
- Journal Title
  
  Heart Rhythm
  
  Volume: 14 Issue: 1 Pages: 120-127
- DOI
  10.1016/j.hrthm.2016.10.019
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-16K15443, KAKENHI-PROJECT-16K19409, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-17H04178, KAKENHI-PROJECT-26293189
[Journal Article] An oxidative stress biomarker, urinary 8-hydroxy-2'-deoxyguanosine, predicts cardiovascular-related death after steroid therapy for patients with active cardiac sarcoidosis.2016
- Author(s)
  Myoren T, Kobayashi S, Oda S, Nanno T, Ishiguchi H, Murakami W, Okuda S, Okada M, Takemura G, Suga K, Matsuzaki M, Yano M.
- Journal Title
  
  Int J Cardiol
  
  Volume: 17 Pages: 206-213
- DOI
  10.1016/j.ijcard.2016.03.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670404, KAKENHI-PROJECT-26293189, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-16K09509, KAKENHI-PROJECT-26463081, KAKENHI-PROJECT-16K15443
[Journal Article] Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca2+ Leakage through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Isoproterenol in Failing Cardiomyocytes.2016
- Author(s)
  Murakami W, Kobayashi S, Susa T, Nanno T, Ishiguchi H, Myoren T, Nishimura S, Kato T, Hino A, Oda T, Okuda S, Yamamoto T, Yano M.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 9 Pages: e0163250-e0163250
- DOI
  10.1371/journal.pone.0163250
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-16K15443, KAKENHI-PROJECT-26293189
[Journal Article] Relationship between the myocardial oxidative stress and cardiac sympathetic hyperactivity in patients with takotsubo cardiomyopathy.2016
- Author(s)
  Seiko Oda, Shigeki Kobayashi, Takuma Nanno, Hironori Ishiguchi, Takeki Myoren, Wakako Murakami, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Jutaro Yamada, Takayuki Okamura, Masunori Matsuzaki, Masafumi Yano.
- Journal Title
  
  Bulltin of the Yamaguchi Medical School
  
  Volume: 63 Pages: 5-16
- NAID
  120005842748
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09142
[Journal Article] A low-dose β1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulum.2015
- Author(s)
  Kobayashi S, Susa T, Ishiguchi H, Myoren T, Murakami W, Kato T, Fukuda M, Hino A, Suetomi T, Ono M, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Okuda S, Doi M, Yamamoto T, Yano M
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 1 Pages: e0114314-e0114314
- DOI
  10.1371/journal.pone.0114314
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26293189, KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-26670404
[Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine as a novel biomarker of inflammatory activity in patients with cardiac sarcoidosis2015
- Author(s)
  Kobayashi S, Myoren T, Oda S, Inari M, Ishiguchi H, Murakami W, Fukuda M, Tanaka T, Okuda S, Nao T, Doi M, Yamada J, Okamura T, Hoshii Y, Suga K, Matsuzaki M, Yano M.
- Journal Title
  
  Int J Cardiol.
  
  Volume: 190 Pages: 319-328
- DOI
  10.1016/j.ijcard.2015.04.144
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142, KAKENHI-PROJECT-26670404, KAKENHI-PROJECT-26293189
[Journal Article] Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes2014
- Author(s)
  Fukuda M, Yamamoto T, Nishimura S, Kato T, Murakami W, Hino A, Ono M, Tateishi H, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 448(1) Issue: 1 Pages: 1-7
- DOI
  10.1016/j.bbrc.2014.03.152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-23591082, KAKENHI-PROJECT-23592256, KAKENHI-PROJECT-26293189, KAKENHI-PROJECT-26670404
[Journal Article] A low-dose β 1-blocker effectively and safely slows the heart rate in patients with acute decompensated heart failure and rapid atrial fibrillation2014
- Author(s)
  Kobayashi S, Murakami W, Myoren T, Tateishi H, Okuda S, Doi M, Nao T, Wada Y, Matsuzaki M, Yano M
- Journal Title
  
  Cardiology
  
  Volume: 127(2) Issue: 2 Pages: 105-13
- DOI
  10.1159/000355312
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-23592256
[Journal Article] Enhanced binding of calmodulin to RyR2 corrects arrhythmogenic channel disorder in CPVT-associated myocytes2014
- Author(s)
  Fukuda M, Yamamoto T, Nishimura S, Kato T, Murakami W, Hino A, Ono M, Tateishi H, Oda T, Okuda S, Kobayashi S, Koseki N, Kyushiki H, Yano M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592256
[Journal Article] A low-doseβ1 blocker effectively and safely slows heart rate in patients with acute decompensated heart failure and rapid atrial fibrillation2014
- Author(s)
  Kobayashi S, Murakami W, Myoren T, Tateishi H, Okuda S, Doi M, Nao T, Wada Y, Matsuzaki M. Yano M
- Journal Title
  
  Cardiology
  
  Volume: 127 Pages: 105-113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592256
[Journal Article] Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy2013
- Author(s)
  Fujita T, Fujino N, Anan R, Tei C, Kubo T, Doi Y, Kinugawa S, Tsutsui H, Kobayashi S, Yano M, Asakura M, Kitakaze M, Komuro I, Konno T, Hayash Hi, Kawashiri M, Ino H, Yamagishi M
- Journal Title
  
  JACC Heart Failure
  
  Volume: 6 Pages: 459-466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592256
[Journal Article] Sarcomere Gene Mutations Are Associated With Increased Cardiovascular Events in Left Ventricular Hypertrophy : Results From Multicenter Registration in Japan.2013
- Author(s)
  Fujita T, Komuro I (18人中13番目）
- Journal Title
  
  JACC Heart Fail
  
  Volume: 6 Issue: 6 Pages: 459-466
- DOI
  10.1016/j.jchf.2013.08.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229010, KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-23591049, KAKENHI-PROJECT-23591078, KAKENHI-PROJECT-23592256, KAKENHI-PROJECT-24591041, KAKENHI-PROJECT-24790748, KAKENHI-PROJECT-25460648
[Journal Article] Urinary 8-hydroxy-2' -deoxyguanosine as a novel biomarker for predicting cardiac events and evaluating the effectiveness of carvedilol treatment in patients with chronic systolic heart failure2012
- Author(s)
  Susa T, Kobayashi S, Tanaka T, Murakami W, Akashi S, Kunitsugu I, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Ueyama T, Okamura T, Yano M, Matsuzaki M
- Journal Title
  
  Circ J
  
  Volume: 76(1) Pages: 117-26
- NAID
  10030034360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390215
[Journal Article] Urinary 8-Hydroxy-2'-Deoxyguanosine as a Novel Biomarker for Predicting Cardiac Events and Evaluating the Effectiveness of Carvedilol Treatment in Patients With Chronic Systolic Heart Failure2012
- Author(s)
  Susa T, et al
- Journal Title
  
  Circ J
  
  Volume: 76 Issue: 1 Pages: 117-126
- DOI
  10.1253/circj.CJ-11-0537
- NAID
  10030034360
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-23592256
[Journal Article] Low-Dose β-Blocker in Combination With Milrinone Safely Improves Cardiac Function and Eliminates Pulsus Alternans in Patients With Acute Decompensated Heart Failure2012
- Author(s)
  Shigeki Kobayashi et al
- Journal Title
  
  Circ J
  
  Volume: 76 Issue: 7 Pages: 1646-1653
- DOI
  10.1253/circj.CJ-12-0033
- NAID
  10030503344
- ISSN
  1346-9843, 1347-4820
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-23592256
[Journal Article] Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts2012
- Author(s)
  Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M
- Journal Title
  
  Cardiovasc Res
  
  Volume: 96(3) Issue: 3 Pages: 433-43
- DOI
  10.1093/cvr/cvs271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-23591082, KAKENHI-PROJECT-23592256
[Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine as a novel biomarker for predicting cardiac events and evaluating the effectiveness of carvedilol treatment in patients with chronic systolic heart failure2012
- Author(s)
  Susa T, Kobayashi S, Tanaka T, Murakami W, Akashi S, Kunitsugu I, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Okamura T, Yano M, Matsuzaki M
- Journal Title
  
  Circ J
  
  Volume: 76 Pages: 117-26
- NAID
  10030034360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592256
[Journal Article] A low-doseβblocker in combination with milrinone safely improves cardiac function and eliminates pulsus alternansin patients with acute decompensated heart failure2012
- Author(s)
  Kobayashi S, Susa T, Tanaka T, Murakami W, Fukuta S, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Okamura T, Yano M, Matsuzaki M
- Journal Title
  
  Circ J
  
  Volume: 76 Pages: 1646-53
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592256
[Journal Article] Low-dose β -blocker in combination with milrinone safely improves cardiac function and eliminates pulsus alternans in patients with acute decompensated heart failure2012
- Author(s)
  Kobayashi S, Susa T, Tanaka T, Murakami W, Fukuta S, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Okamura T, Yano M, Matsuzaki M
- Journal Title
  
  Circ J
  
  Volume: 76(7) Pages: 1646-53
- NAID
  10030503344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390215
[Journal Article] Enhanced binding of calmodulin to the ryanodine receptor corrects contractile dysfunction in failing hearts2012
- Author(s)
  Hino A, Yano M, Kato T, Fukuda M, Suetomi T, Ono M, Murakami W, Susa T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M
- Journal Title
  
  Cardiovasc Res
  
  Volume: 96 Pages: 433-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592256
[Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure2011
- Author(s)
  Kobayashi S, Susa T, Tanaka T, Wada Y, Okuda S, Doi M, Nao T, Yoshiga Y, Yamada J, Okamura T, Ueyama T, Kawamura S, Yano M, Matsuzaki M
- Journal Title
  
  Eur J Heart Fail
  
  Volume: 13 Pages: 29-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592256
[Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure2011
- Author(s)
  Shigeki Kobayashi
- Journal Title
  
  Euro J Heart Fail
  
  Volume: 13 Pages: 29-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²+ release leading to catecholaminergic polymorphic ventricular tachycardia2011
- Author(s)
  Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M
- Journal Title
  
  Circulation
  
  Volume: 124(6) Pages: 682-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390215
[Journal Article] Urinary 8-Hydroxy-2' -Deoxyguanosine Reflects Symptomatic Status and Severity of Systolic Dysfunction in Patients with Chronic Heart Failure.2011
- Author(s)
  Kobayashi S, Susa T, Tanaka T, Wada Y, Okuda S, Doi M, Nao T, Yoshiga Y, Yamada J, Okamura T, Ueyama T, Kawamura S, Yano M, Matsuzaki M.
- Journal Title
  
  Eur J Heart Fail. 13(1)
  
  Pages: 29-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure2011
- Author(s)
  Shigeki Kobayashi
- Journal Title
  
  European Journal of Heart Faililure
  
  Volume: 13 Issue: 1 Pages: 29-36
- DOI
  10.1093/eurjhf/hfq178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659154, KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-23592256
[Journal Article] Urinary8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure.2011
- Author(s)
  Kobayashi S, Susa T, Tanaka T, Wada Y, Okuda S, Doi M, Nao T, Yoshiga Y, Yamada J, Okamura T, Ueyama T, Kawamura S, Yano M, Matsuzaki M.
- Journal Title
  
  Eur J Heart Fail. 13
  
  Pages: 29-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca2+ release leading to catecholaminergic polymorphic ventricular tachycardia.2011
- Author(s)
  Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Circulation
  
  Volume: 124 Pages: 682-694
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591082
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia2011
- Author(s)
  Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M
- Journal Title
  
  Circulation
  
  Volume: 124(6) Pages: 682-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591082
[Journal Article] Urinary 8-hydroxy-2'-deoxyguanosine reflects symptomatic status and severity of systolic dysfunction in patients with chronic heart failure.2011
- Author(s)
  Kobayashi S, Susa T, Tanaka T, Wada Y, Okuda S, Doi M, Nao T, Yoshiga Y, Yamada J, Okamura T, Ueyama T, Kawamura S, Yano M, Matsuzaki M.
- Journal Title
  
  Eur J Heart Fail. 13
  
  Pages: 29-36
- Data Source
  KAKENHI-PROJECT-20390226
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia2011
- Author(s)
  Suetomi T, Yano M, Uchinoumi H, Fukuda M, Hino A, Ono M, Xu X, Tateishi H, Okuda S, Doi M, Kobayashi S, Ikeda Y, Yamamoto T, Ikemoto N, Matsuzaki M
- Journal Title
  
  Circulation
  
  Volume: 124 Pages: 682-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592256
[Journal Article] Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca^<2+> release leading to catecholaminergic polymorphic ventricular tachycardia2011
- Author(s)
  Takeshi Suetomi
- Journal Title
  
  Circulation
  
  Volume: 124 Issue: 6 Pages: 682-694
- DOI
  10.1161/circulationaha.111.023259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390241, KAKENHI-PROJECT-21590932, KAKENHI-PROJECT-22659154, KAKENHI-PROJECT-23390215, KAKENHI-PROJECT-23592256
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2 (R2474S/+) knock-in mouse model.2010
- Author(s)
  Kobayashi S, Yano M, Uchinoumi H, Suetomi T, Susa T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Yamamoto T, Matsuzaki M.
- Journal Title
  
  Cir J. 74
  
  Pages: 2579-2584
- NAID
  10027424202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.2010
- Author(s)
  Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Biochem Biophys Res Commun. 394
  
  Pages: 660-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390226
[Journal Article] Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.2010
- Author(s)
  Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, lkeda Y, lkemoto N, Matsuzaki M.
- Journal Title
  
  Biochem Biophys Res Commun. 394(3)
  
  Pages: 660-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.2010
- Author(s)
  Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Circ Res. 106
  
  Pages: 1413-1424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390226
[Journal Article] Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure.2010
- Author(s)
  Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cardiovasc Res. 87
  
  Pages: 609-617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2R2474S/+ Knock-In Mouse Model2010
- Author(s)
  Shigeki Kobayashi
- Journal Title
  
  Circ J
  
  Volume: 74 Pages: 2579-2584
- NAID
  10027424202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia in a RyR2(R2474S/+)Knock-In Mouse Model.2010
- Author(s)
  Shigeki Kobayashi
- Journal Title
  
  Circulation Journal
  
  Volume: 74 Pages: 2579-2584
- NAID
  10027424202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390226
[Journal Article] Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.2010
- Author(s)
  Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, lkeda Y, Ohkusa T, lkemoto N, Matsuzaki M.
- Journal Title
  
  Circ Res. 106(8)
  
  Pages: 1413-1424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2^<R2474S/+> knock-in mouse model.2010
- Author(s)
  Kobayashi S, Yano M, Uchinoumi H, Suetomi T, Susa T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Yamamoto T, Matsuzaki M.
- Journal Title
  
  Circ J. 74
  
  Pages: 2579-2584
- NAID
  10027424202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390226
[Journal Article] Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.2010
- Author(s)
  Xu X, Yano M, Uchinoumi H, Hino A, Suetomi T, Ono M, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Biochem Biophys Res Commun. 394
  
  Pages: 660-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure.2010
- Author(s)
  Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cardiovasc Res. 87(4)
  
  Pages: 609-617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390226
[Journal Article] Catecholaminergic polymorphic ventricular tachycardia is caused by mutation-linked defective conformational regulation of the ryanodine receptor.2010
- Author(s)
  Uchinoumi H, Yano M, Suetomi T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cir Res. 81
  
  Pages: 1413-1423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure.2010
- Author(s)
  Ono M, Yano M, Hino A, Suetomi T, Xu X, Susa T, Uchinoumi H, Tateishi H, Oda T, Okuda S, Doi M, Kobayashi S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cardiovasc Res. 87(4)
  
  Pages: 609-617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2 R2474S/+knock-in mouse model.2010
- Author(s)
  Kobayashi S, Yano M, Uchinoumi H, Suetomi T, Susa T, Ono M, Xu X, Tateishi H, Oda T, Okuda S, Doi M, Yamamoto T, Matsuzaki M.
- Journal Title
  
  Circ J. 74(12)
  
  Pages: 2579-2584
- NAID
  10027424202
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing inter-domain interactions within the rvanodine recentor2009
- Author(s)
  Shigeki Kobayashi
- Journal Title
  
  J Am Coll Cardiol 53
  
  Pages: 1993-2005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Role of ryanodine receptor as a Ca(2+) regulatory center in normal and failing hearts.2009
- Author(s)
  Yano M, Yamamoto T, Kobayashi S, Matsuzaki M.
- Journal Title
  
  J Cardiol. 53
  
  Pages: 1-7
- NAID
  10025182309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Role of ryanodine receptor as a Ca(2+) regulatory center in normal and failing hearts.2009
- Author(s)
  Yano M, Yamamoto T, Kobayashi S, Matsuzaki M.
- Journal Title
  
  J Cardiol. 53 Review
  
  Pages: 1-7
- NAID
  10025182309
- Data Source
  KAKENHI-PROJECT-20390226
[Journal Article] Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Markedly Improves the Function of Failing Cardiomyocytes by Stabilizing Interdomain Interactions Within the Ryanodine Receptor2009
- Author(s)
  Kobayashi S
- Journal Title
  
  Journal of the American College of Cardiology 53
  
  Pages: 1993-2005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.2009
- Author(s)
  Shigeki Kobayashi
- Journal Title
  
  Journal of American College of Cardiology 53
  
  Pages: 1993-2005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390226
[Journal Article] Role of ryanodine receptor as a Ca2+ regulatory center in normal and failing hearts.2009
- Author(s)
  Yano M, Yamamoto T, Kobayashi S, Matsuzaki M.
- Journal Title
  
  J Cardiol. 53(1)
  
  Pages: 1-7
- NAID
  10025182309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.2009
- Author(s)
  Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, Xu X, Uchinoumi H, Okuda S, Yamamoto T, Koseki N, Kyushiki H, Ikemoto N, Matsuzaki M.
- Journal Title
  
  J Am Coll Cardiol. 53
  
  Pages: 1993-2005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390226
[Journal Article] Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.2009
- Author(s)
  Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cardiovasc Res. 81
  
  Pages: 536-545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390226
[Journal Article] Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.2009
- Author(s)
  Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cardiovasc Res. 81(3)
  
  Pages: 536-545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor.2009
- Author(s)
  Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, Xu X, Uchinoumi H, Okuda S, Yamamoto T, Koseki N, Kyushiki H, lkemoto N, Matsuzaki M.
- Journal Title
  
  J Am Coll Cardiol. 53(21)
  
  Pages: 1993-2005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.2009
- Author(s)
  Tateishi H, Yano M, Mochizuki M, Suetomi T, Ono M, Xu X, Uchinoumi H, Okuda S, Oda T, Kobayashi S, Yamamoto T, Ikeda Y, Ohkusa T, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Cardiovasc Res. 81
  
  Pages: 536-545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing inter-domain interactions within the ryanodine receptor.2009
- Author(s)
  Shigeki Kobayashi
- Journal Title
  
  J Am Coll Cardiol 53
  
  Pages: 1993-2005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing inter-domain interactions within the ryanodine receptor.2009
- Author(s)
  Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, Xu X, Uchinoumi H, Okuda S, Yamamoto T, Koseki N, Kyushiki H, IkemotoN, Matsuzaki M.
- Journal Title
  
  J Am Coll Cardiol. 53
  
  Pages: 1993-2005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Defective Ca2+ cycling as a key pathogenic mechanism of heart failure.2008
- Author(s)
  Yano M, Yamamoto T, Kobayashi S, Ikeda Y, Matsuzaki M.
- Journal Title
  
  Circ J. 72 Suppl A Review
- NAID
  110006935628
- Data Source
  KAKENHI-PROJECT-20390226
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts2008
- Author(s)
  Yamamoto, T, Yano, M, Xu, X, Uchinoumi, H, Tateishi, H, Mochizuki, M, Oda, T, Kobayashi, S, Ikemoto, N, Matsuzaki, M
- Journal Title
  
  Circulation 117
  
  Pages: 762-72
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591706
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts.2008
- Author(s)
  Yamamoto T, Yano M, Xu X, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Kobayashi S, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Circulation. 117(6)
  
  Pages: 762-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] Identification of target domains of the cardiac ryanodine receptor to correct channel disorder in failing hearts.2008
- Author(s)
  Yamamoto T, Yano M, Xu X, Uchinoumi H, Tateishi H, Mochizuki M, Oda T, Kobayashi S, Ikemoto N, Matsuzaki M.
- Journal Title
  
  Circulation. 117
  
  Pages: 762-772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Defective Ca2+ cycling as a key pathogenic mechanism of heart failure.2008
- Author(s)
  Yano M, Yamamoto T, Kobayashi S, Ikeda Y, Matsuzaki M.
- Journal Title
  
  Circ J. 72
  
  Pages: 22-30
- NAID
  110006935628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591805
[Journal Article] Defective Ca2+ cycling as a key pathogenic mechanism of heart failure.2008
- Author(s)
  Yano M, Yamamoto T, Kobayashi S, Ikeda Y, Matsuzaki M.
- Journal Title
  
  Circ J. 72
- NAID
  110006935628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590868
[Journal Article] 心不全におけるリアノジン受容体機能異常2007
- Author(s)
  小林茂樹
- Journal Title
  
  細胞工学, 秀潤社 26
  
  Pages: 365-370
- Data Source
  KAKENHI-PROJECT-18591706
[Journal Article] Scavenging free radicals by low-dose carvedilol prevents redox-dependent Ca^<2+>leak via stabilization of ryanodine receptor in heart failure2007
- Author(s)
  Mamoru, Mochizuki, Masafumi, Yano, Tetsuro, Oda, Hiroki, Tateishi, Shigeki Kobayashi, Takeshi, Yamamoto, Yasuhiro, Ikeda, Tomoko, Ohkusa, Noriaki, Ikemoto, Masunori, Matsuzaki
- Journal Title
  
  J Am Coll Cardiol 49
  
  Pages: 1722-1732
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591706
[Presentation] Stabilizing Cardiac Ryanodine Receptor with Dantrolene Treatment Prevents Left Ventricular Remodeling in Pressure-overloaded Heart Failure Mice2023
- Author(s)
  Yasutake Yano, Shigeki Kobayashi, Tomoyuki Uchida, Jyunya Nawata, Yoshihide Nakamura, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] ALK陽性未分化大細胞リンパ腫における微小播種性病変に関わる原因遺伝子の解明2023
- Author(s)
  深野玲司　飯島友加　川口浩史　中山秀樹　小林良二　岩淵英人　関水匡大　水上洋一　森鉄也　堀部敬三
- Organizer
  第65回日本小児血液・がん学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03358
[Presentation] 心筋型リアノジン受容体 4 量体構造の安定化は心筋梗塞後の予後を改善する2023
- Author(s)
  藤井翔平、小林茂樹、矢野泰健、内田智之、常　耀偉、中村吉秀、末冨　建、内海仁志、小田哲郎、岡村誉之、山本　健、矢野雅文
- Organizer
  第122回日本循環器学会中国四国合同地方会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] 18F-FDG-PET and an Oxidative Stress Marker after Immunosuppressive Therapy Predict Major Adverse Cardiovascular Events in Cardiac Sarcoidosis2023
- Author(s)
  Yusuke Nakashima, shigeki Kobayashi, Maho Ishikawa, Yasutake Yano, Shohei Fujii, Hironori Ishiguchi, Masakazu Fukuda, Yosuke Miyazaki, Tatsuhiro Fujimura, Hitoshi Uchinoumi, Mamoru Mochiduki, Masafumi Yano
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] リアノジン受容体安定化治療が心筋梗塞後の左室リモデリングや心室頻拍を抑制する2023
- Author(s)
  藤井翔平、小林茂樹、矢野泰健、内田智之、常　耀偉、縄田純也、中村吉秀、末冨　建、内海仁志、小田哲郎、岡村誉之、山本　健、矢野雅文
- Organizer
  第9回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] 細胞内Ca2+動態の観点から新たな不整脈・心不全治療を考える～心筋型リアノジン受容体安定化の機序解明から臨床応用へ～2023
- Author(s)
  小林茂樹、山本健、矢野雅文
- Organizer
  第71回日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] Dantrolene Improves Diastolic Function of Left Ventricle in Mineralcorticoid-induced Hypertensive Rats2023
- Author(s)
  Junya Nawata, Takeshi Yamamoto, Tomoyuki Uchida, Yasutake Yano, Shinji Tanaka, Shohei Fujii, Yoshihide Nakamura, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] Stabilization of RyR2 with Dantrolene Treatment Prevents Ventricular Tachycardia and Left Ventricular Remodeling in Post Myocardial Infarction Mice2023
- Author(s)
  Shohei Fujii, Shigeki Kobayashi, Yasutake Yano, Tomoyuki Uchida, Yaowei Chang, Junya Nawata, Yoshihide Nakamura, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] アミオダロン治療抵抗性の虚血性心疾患に合併した多形性心室頻拍ストームに対して、ダントロレンが有効であった2症例2023
- Author(s)
  縄田純也、小林茂樹、石川真帆、中嶋佑輔、久岡雅弘、中村吉秀、小室あゆみ、石口博智、福田昌和、末冨　建、宮崎要介、藤村達大、望月守、岡村誉之
- Organizer
  第71回日本心臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] Dantrolene, RyR2 Stabilizer, Restores the Impaired Diastolic Function in the Pressure-overloaded Hypertrophied Heart2023
- Author(s)
  Yaowei Chang, Shigeki Kobayashi, Yasutake Yano,Tomoyuki Uchida, Junya Nawata, Shohei Fujii, Yoshi Nakamura, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第87回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] Off-Label Use of Dantrolene for Lethal Arrhythmia in Heart Failure2022
- Author(s)
  小林茂樹、山本健、矢野雅文
- Organizer
  The 86th Annual Scientific Meeting of the Japanese Circulation Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] Stabilization of RyR2 maintains right ventricular function, and improves prognosis in pulmonary hypertension2021
- Author(s)
  Shinji Tanaka，Takeshi Yamamoto，Jyunya Nawata，Shohei Fujii，Yoshihide Nakamura，Hitoshi Uchinoumi，Tetsuro Oda，Shigeki Kobayashi，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] RyR2-targeting therapy improves left ventricular remodeling after myocardial infarction2021
- Author(s)
  藤井翔平、小林茂樹、矢野雅文
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] Dantrolene prevents right ventricular remodeling and ventricular tachycardia in pulmonary artery hypertension2021
- Author(s)
  Shinji Tanaka, Takeshi Yamamoto, Junya Nawata, Shohei Fujii, Yoshihide Nakamura, Michiaki Kohno, Hitoshi Uchinoumi, Tetsuro Oda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第37回国際心臓研究学会日本部会
- Data Source
  KAKENHI-PROJECT-18K08039
[Presentation] Sterile inflammation through Ca2+/ Calmodulin-dependent protein kinase II (CaMKII) signaling is essential for adverse cardiac remodeling2021
- Author(s)
  末冨建、小田哲郎、小林茂樹、矢野雅文
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] RyR2-targeting therapy improves left ventricular remodeling after myocardial infarction2021
- Author(s)
  Shohei Fujii，Shigeki Kobayashi，Yaowei Chang，Jyunya Nawata，Shinji Tanaka，Yoshihide Nakamura，Takeshi Suetomi，Hitoshi Uchinoumi，Tetsuro Oda，Takeshi Yamamoto，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] Improving Ca2+ handling prevent doxorubicin induced cardiomyopathy in mice2021
- Author(s)
  中村吉秀、山本健、小林茂樹、矢野雅文
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] Sterile Inflammation through Ca2+ Calmodulin-Dependent Protein Kinase II is Essential for Adverse Cardiac Remodeling2021
- Author(s)
  末冨建、奥田真一、岡本陽子、楯田聡美、河野通暁、梶井俊郎、内海仁志、小田哲郎、小林茂樹、山本　健、矢野雅文
- Organizer
  第84回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08039
[Presentation] Stabilization of RyR2 maintains right ventricular function, and improves prognosis in pulmonary hypertension2021
- Author(s)
  田中慎二、山本健、小林茂樹、矢野雅文
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] Enhancing calmodulin binding affinity to ryanodine receptor type2 can be a therapeutic target for heart failure with preserved ejection fraction2021
- Author(s)
  Tomoyuki Uchida，Tetsuro Oda，Takeshi Suetomi，Takeshi Yamamoto，Shigeki Kobayashi，Yoshihide Nakamura，Shohei Fujii，Hitoshi Uchinoumi，Shinji Tanaka，Jyunya Nawata，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] Enhancing calmodulin binding affinity to ryanodine receptor type2 can be a therapeutic target for heart failure with preserved ejection fraction2021
- Author(s)
  内田智之、小田哲郎、山本健、小林茂樹、矢野雅文
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-21K08128
[Presentation] Sterile inflammation through Ca2+/ Calmodulin-dependent protein kinase II (CaMKII) signaling is essential for adverse cardiac remodeling2021
- Author(s)
  Takeshi Suetomi，Shinichi Okuda，Satomi Tateda，Yoko Okamoto，Hitoshi Uchinoumi，Tetsuro Oda，Shigeki Kobayashi，Takeshi Yamamoto，Masafumi Yano
- Organizer
  第38回国際心臓研究学会日本部会総会
- Data Source
  KAKENHI-PROJECT-20H03677
[Presentation] Anti-inflammatory approach for heart failure targeting Calcium-Calmodulin dependent protein kinase2020
- Author(s)
  Takeshi Suetomi, Michiaki Kono, Toshiro Kajii, Masaki Tamitani, Yoshihide Nakamura, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第84回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08039
[Presentation] Critical Role of Ryanodine Receptor Bound Calmodulin to Prevent Catecholaminergic Polymorphic Ventricular Tachycardia2019
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Shigeki Kobayashi, Masaki Tamitani, Yoriomi Hamada, Go Fukui, Xiaojuan Xu, Shigehiko Nishimura, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Masafumi Yano
- Organizer
  AHA BCVS 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08108
[Presentation] Stabilization of CaMKII-phosphorylated RyR2 By Dantrolene Prevents the Development of Age-related Cardiomyopathy in CaMKIIδc Transgenic Mice2019
- Author(s)
  Yoko Sufu-Shimizu, Shinichi Okuda, Yoko Okamoto, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Critical Role of Ryanodine Receptor Bound Calmodulin to Prevent Catecholaminergic Polymorphic Ventricular Tachycardia2019
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Shigeki Kobayashi, Masaki Tamitani, Yoriomi Hamada, Go Fukui, Xiaojuan Xu, Shigehiko Nishimura, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Masafumi Yano
- Organizer
  AHA BCVS
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] リアノジン受容体を分子標的とした心不全・不整脈治療2019
- Author(s)
  小林茂樹、山本健、矢野雅文
- Organizer
  第４０回日本循環制御医学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08039
[Presentation] Arrhythmia Treatment Targeting Ryanodine receptor2019
- Author(s)
  Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  The 66th Annual Meeting of the Japanese Heart Rhythm Sociaty
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08039
[Presentation] Stabilization of CaMKII-phosphorylated RyR2 By Dantrolene Prevents the Development of Age-related Cardiomyopathy in CaMKIIδc Transgenic Mice2019
- Author(s)
  Yoko Sufu-Shimizu, Shinichi Okuda, Yoko Okamoto, Takayoshi Kato, Hitoshi Uchinoumi, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08108
[Presentation] Stabilization of CaMKII-phosphorylated RyR2Prevents the Development of Age-related Car-diomyopathy Caused by Transgenic CaMKII δ cOverexpression2018
- Author(s)
  Yoko Sufu, Shinichi Okuda, Yoko Okamoto, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dantrolene Prevents Right Ventricular Hypertro-phy without Reducing Pulmonary Arterial Pres-sure in Monocrotaline-Induced PAH in Mice2018
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Go Fukui, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Dantrolene Prevents Right Ventricular Hypertro-phy without Reducing Pulmonary Arterial Pres-sure in Monocrotaline-Induced PAH in Mice2018
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Go Fukui, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] カルシウム制御による心不全治療戦略 ―リアノジン受容体安定化治療の可能性について―2018
- Author(s)
  小林茂樹
- Organizer
  第22回日本心不全学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08039
[Presentation] Ryanodine Receptor Targeting Therapy InhibitsCardiomyocyte Hypertrophy and RelaxationImpairment in the Compensated Pressure-Overloaded Heart2018
- Author(s)
  Michiaki Kono, Shigeki Kobayashi, Toshiro Kajii, Takuma Nanno, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Stabilization of CaMKII-phosphorylated RyR2Prevents the Development of Age-related Car-diomyopathy Caused by Transgenic CaMKIIδc Overexpression2018
- Author(s)
  Yoko Sufu, Shinichi Okuda, Yoko Okamoto, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Ryanodine Receptor Targeting Therapy InhibitsCardiomyocyte Hypertrophy and RelaxationImpairment in the Compensated Pressure- Overloaded Heart2018
- Author(s)
  Michiaki Kono, Shigeki Kobayashi, Toshiro Kajii, Takuma Nanno, Hironori Ishiguchi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Effect of Site Dependent RyR Stabilizers; a Clue to Trace a Signal Transmission Pathway Inside the RyR Molecule2017
- Author(s)
  Go Fukui, Takeshi Yamamoto, Michiaki Kono, Yoshihide Nakamura, Takuma Nanno, Yoriomi Hamada, Yoko Sufu, Hironori Ishiguchi, Shigehiko Nishimura, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dantrolene Prevents Right Ventricular Hypertrophy Without Reducing Pulmonary Arterial Pressure In Monocrotaline-induced PAH In Mice2017
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Michiaki kono, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Hironori Ishiguchi, Shigehiko Nishimura, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142
[Presentation] Effect of Site Dependent RyR Stabilizers; a Clue to Trace a Signal Transmission Pathway Inside the RyR Molecule2017
- Author(s)
  Go Fukui, Takeshi Yamamoto, Michiaki Kono, Yoshihide Nakamura, Takuma Nanno, Yoriomi Hamada, Yoko Sufu, Hironori Ishiguchi, Shigehiko Nishimura, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Stabilization of Camkii-Phosphorylated Ryr2 by Dantrolene Prevents the Development of Age-Related Cardiomyopathy Caused by CamkiiδC Overexpression2017
- Author(s)
  Yoko S Shimizu, Shinichi Okuda, Yoko Okamoto, Shigehiko Nishimura, Takayoshi Kato, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Dantrolene Prevents Right Ventricular Hypertrophy Without Reducing Pulmonary Arterial Pressure In Monocrotaline-induced PAH In Mice2017
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Michiaki kono, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Hironori Ishiguchi, Shigehiko Nishimura, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dantrolene Prevents Right Ventricular Hypertrophy Without Reducing Pulmonary Arterial Pressure In Monocrotaline-induced PAH In Mice2017
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Michiaki kono, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Hironori Ishiguchi, Shigehiko Nishimura, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-17H04178
[Presentation] Stabilization of Camkii-Phosphorylated Ryr2 by Dantrolene Prevents the Development of Age-Related Cardiomyopathy Caused by CamkiiδC Overexpression2017
- Author(s)
  Yoko S Shimizu, Shinichi Okuda, Yoko Okamoto, Shigehiko Nishimura, Takayoshi Kato, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto and Masafumi Yano
- Organizer
  90th Scientific Session of American Heart Association
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Ryanodine　receptor Targeting Therapy Restores Abnormal Intracellular Ca2+ Handling in the Compensated Pressure-Overloaded Heart2017
- Author(s)
  Shigeki Kobayashi, Masafumi Yano
- Organizer
  The 81st Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  石川県、金沢市　（ホテル金沢）
- Year and Date
  2017-03-19
- Invited
- Data Source
  KAKENHI-PROJECT-15K09142
[Presentation] Correction of the Defective Channel Gating of Cardiac Ryanodine Receptor Improves Cardiac Function and Suppresses Ventricular Arrhythmia in Post Myocardial Infarction Heart Failure2016
- Author(s)
  Hironori Ishiguchi, Shigeki Kobayashi, Michiaki Kohno, Takuma Nanno, Gou Fukui, Yoko Sufu-Shimizu, Yoriomi Hamada, Takako Maeda, Shigehiko Nishimura, Tetsuro Oda, Shinnichi Okuda, Takeshi Ueyama, Takeshi Yamamoto, Masafumi Yano
- Organizer
  89th Scientific Session of American Heart Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142
[Presentation] Correction of Impaired Calmodulin Binding to Ryr2 as a Novel Therapy of Lethal Arrhythmia in the Pressure-Overloaded Heart Failure2016
- Author(s)
  Yoshihide Nakamura, Takeshi Yamamoto, Takayoshi Kato, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Shigehiko Nishimura, Hironori Ishiguchi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi and Masafumi Yano
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] Nuclear Translocation of Calmodulin, Which Dissociated From Cardiac Ryanodine Receptor, Promotes the Pathological Cardiac Hypertrophy2016
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Takayoshi Kato, Shigehiko Nishimura, Go Fukui, Shinichi Okuda, Shigeki Kobayashi, Donald Bers and Masafumi Yano
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] Correction Of Impaired Calmodulin Binding To Ryr2 As A Novel Therapy Of Lethal Arrhythmia In The Pressure-overloaded Heart Failure2016
- Author(s)
  Yoshihide Nakamura,Takeshi Yamamoto, Yamaguchi Univ Graduate Sch of Med, Une, Japan; Takayoshi Kato, Yoriomi Hamada, Go Fukui, Yoko Sufu, Takuma Nanno, Shigehiko Nishimura, Hironori Ishiguchi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  89th Scientific Session of American Heart Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Improvement of Defective Channel Function on RyR2 Mediated by CaMKII Activation Suppresses Arrhythmogenesis in TnT-related Hypertrophic Cardiomyopathy2016
- Author(s)
  Shinichi Okuda, Yoko Sufu-Shimizu, Takayoshi Kato, Yoko Okamoto, Shigehiko Nishimura, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto and Masafumi Yano
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] ダントロレンによるリアノジン受容体を分子標的とした心不全・不整脈治療の臨床応用2016
- Author(s)
  Shigeki Kobayashi
- Organizer
  第37回日本臨床薬理学会学術総会
- Place of Presentation
  鳥取県、米子市　（米子コンベンションセンター）
- Year and Date
  2016-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-15K09142
[Presentation] Myocardial Oxidative Stress, Urinary 8-hydroxy-2’-deoxyguanosine, is Associated With Sustained Ventricular Tachycardia in Patient With Active Cardiac Sarcoidosis2016
- Author(s)
  Hironori Ishiguchi, Shigeki Kobayashi, Michiaki Kohno, Takuma Nanno, Takeki Myoren, Seiko Oda, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Jutaro Yamada, Takayuki Okamura, Masafumi Yano
- Organizer
  89th Scientific Session of American Heart Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142
[Presentation] Correction of the Defective Channel Gating of Cardiac Ryanodine Receptor Improves Cardiac Function and Suppresses Ventricular Arrhythmia in Post Myocardial Infarction Heart Failure2016
- Author(s)
  Hironori Ishiguchi, Shigeki Kobayashi, Michiaki Kohno, Takuma Nanno, Gou Fukui, Yoko Sufu-Shimizu, Yoriomi Hamada, Takako Maeda, Shigehiko Nishimura, Tetsuro Oda, Shinnichi Okuda, Takeshi Ueyama, Takeshi Yamamoto and Masafumi Yano
- Organizer
  American Heart Association Scientific Sessions 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-11-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] Dantrolene Enhances Binding of Calmodulin to RyR2 in CPVT Which Mutation Located at Central Domain but Does Not Enhance That in CPVT With Mutation at CaM-like Domain2015
- Author(s)
  Shigehiko Nishimura，Takeshi Yamamoto，Go Fukui，Takako Maeda，Akihiro Hino，Takeshi Suetomi，Makoto Ono，Mamoru Mochizuki，Tetsuro Oda，Shinichi Okuda，Shigeki Kobayashi，Masafumi Yano
- Organizer
  88th Scientific Session of American Heart Association
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142
[Presentation] Dantrolene Cannot Inhibit Aberrant Ca2+ Release and Arrhythmias Without Calmodulin in Pressure Overload Heart Failure2015
- Author(s)
  Go Fukui，Takeshi Yamamoto，Tkayoshi Kato，Takako Maeda，Shigehiko Nishimura，Akihiro Hino，Takeshi Suetomi，Makoto Ono，Mamoru Mochizuki，Tetsuro Oda，Shinichi Okuda，Shigeki Kobayashi，Masafumi Yano
- Organizer
  88th Scientific Session of American Heart Association
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142
[Presentation] Dantrolene Enhances Binding of Calmodulin to RyR2 in CPVT Which Mutation Located at Central Domain but Does Not Enhance That in CPVT with Mutation at CaM-like Domain2015
- Author(s)
  Shigehiko Nishimura, Takeshi Yamamoto, Go Fukui, Takako Maeda, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] High Affinity CaM, but Not Normal Affinity CaM Can Prevent Arrhythmias in CPVT Which Mutation Is Located at CaM-like Domain of RyR22015
- Author(s)
  Shigehiko Nishimura, Takeshi Yamamoto, Go Fukui, Takako Maeda, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] High Affinity CaM, but Not Normal Affinity CaM Can Prevent Arrhythmias in CPVT Which Mutation Is Located at CaM-like Domain of RyR22015
- Author(s)
  Shigehiko Nishimura, Takeshi Yamamoto, Go Fukui, Takako Maeda, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] Dantrolene Enhances Binding of Calmodulin to RyR2 in CPVT Which Mutation Located at Central Domain but Does Not Enhance That in CPVT with Mutation at CaM-like Domain2015
- Author(s)
  Shigehiko Nishimura, Takeshi Yamamoto, Go Fukui, Takako Maeda, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dantrolene Cannot Inhibit Aberrant Ca2+ Release and Arrhythmias Without Calmodulin in Pressure Overload Heart Failure.2015
- Author(s)
  Go Fukui, Takeshi Yamamoto, Takayoshi Kato, Takako Maeda, Shigehiko Nishimura, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09085
[Presentation] Dantrolene Cannot Inhibit Aberrant Ca2+ Release and Arrhythmias Without Calmodulin in Pressure Overload Heart Failure.2015
- Author(s)
  Go Fukui, Takeshi Yamamoto, Takayoshi Kato, Takako Maeda, Shigehiko Nishimura, Akihiro Hino, Takeshi Suetomi, Makoto Ono, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  AHA Scientific Sessions 2015
- Place of Presentation
  Orlando, FL (USA)
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293189
[Presentation] A Marked Increase in Myocardial Oxidative Stress Associated With Sympathetic Hyperactivity is Related to Transient Myocardial Dysfunction in Patients With Takotsubo Cardiomyopathy2015
- Author(s)
  Takuma Nanno，Shigeki Kobayashi，Seiko Oda，Hironori Ishiguchi，Takeki Myoren，Yosuke Miyazaki，Takeshi Suetomi，Makoto Ono，Mamoru Mochizuki，Tetsuro Oda，Shinichi Okuda，Jutaro Yamada，Takayuki Okamura，Masafumi Yano
- Organizer
  88th Scientific Session of American Heart Association
- Place of Presentation
  Orlando, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09142
[Presentation] Dantrolene Corrects Aberrant Ca2+ Release and Improves Calmodulin Bindingto RyR2 in CPVT-associated Mutation2014
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Shinichi Okuda, Tetsurou Oda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第７8回日本循環器学会学術集会
- Place of Presentation
  東京、国際フォーラム
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Relationship between Cardiac 18F-FDG-PET/CT Imaging and Urinary 8-hydroxy-2'-deoxyguanosine as a Biomarker of Oxidative Stress in Patients with Cardiac Sarcoidosis2014
- Author(s)
  Shigeki Kobayashi, Wakako Murakami, Takeki Myoren, Masakazu Fukuda, Kosuke Uchida, Makoto Ono, Hiroki Tateishi, Tetsuro Oda, Ryosuke Kametani, Tomoko Nao, Yasuhiro Yoshiga, Jutaro Yamada, Takeshi Ueyama, Takayuki Okamura, Masafumi Yano
- Organizer
  第７8回日本循環器学会学術集会
- Place of Presentation
  東京、国際フォーラム
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Cardiomyocyte Ryanodine Receptor (RyR2) Oxidation in situ Causes Defective Interdomain Interaction and Reduces Calmodulin (CaM) Binding2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  The 78th Annual scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  東京国際フォーラム,東京
- Year and Date
  2014-03-21
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Dantrolene Corrects Aberrant Ca2+ Release and Improves Calmodulin Bindingto RyR2 in CPVT-associated Mutation2014
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Shinichi Okuda, Tetsurou Oda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Relationship between Cardiac 18F-FDG-PET/CT Imaging and Urinary 8-hydroxy-2'-deoxyguanosine as a Biomarker of Oxidative Stress in Patients with Cardiac Sarcoidosis2014
- Author(s)
  Shigeki Kobayashi, Wakako Murakami, Takeki Myoren, Masakazu Fukuda, Kosuke Uchida, Makoto Ohno, Hiroki Tateishi, Tetsuro Oda, Ryosuke Kametani, Tomoko Nao, Yasuhiro Yoshiga, Jutaro Yamada, Takeshi Ueyama, Takayuki Okamura, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Enhanced Binding of Calmodulin to the Ryanodine Receptor Corrects Abnormal Calcium Handling in Pressure Over Loaded Heart Failure2014
- Author(s)
  Takayoshi Katoh, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myoren, Wakako Murakami, Masakazu Fukuda, Makoto Ohno, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  The 78th Annual scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  東京国際フォーラム,東京
- Year and Date
  2014-03-21
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Cardiomyocyte Ryanodine Receptor (RyR2) Oxidation in situ Causes Defective Interdomain Interaction and Reduces Calmodulin (CaM) Binding2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Mapping the Binding Site of RyR2 “Unzipping” Peptide (DPc10) by Fluorescence Resonance Energy Transfer (FRET) in Permeabilized Cardiomyocytes2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Dantrolene Corrects Aberrant Ca2+ Release and Improves Calmodulin Bindingto RyR2 in CPVT-associated Mutation2014
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Shinichi Okuda, Tetsurou Oda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Enhanced Binding of Calmodulin to the Ryanodine Receptor Corrects Abnormal Calcium Handling in Pressure Over Loaded Heart Failure2014
- Author(s)
  Takayoshi Katoh, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myoren, Wakako Murakami, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第７8回日本循環器学会学術集会
- Place of Presentation
  東京、国際フォーラム
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Cardiomyocyte Ryanodine Receptor (RyR2) Oxidation in situ Causes Defective Interdomain Interaction and Reduces Calmodulin (CaM) Binding2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Enhanced Binding of Calmodulin to the Ryanodine Receptor Corrects Abnormal Calcium Handling in Pressure Over Loaded Heart Failure2014
- Author(s)
  Takayoshi Katoh, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myoren, Wakako Murakami, Masakazu Fukuda, Makoto Ohno, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Mapping the Binding Site of RyR2"Unzipping"Peptide (DPc10) by Fluorescence Resonance Energy Transfer (FRET) in Permeabilized Cardiomyocytes2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  The 78th Annual scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  東京国際フォーラム,東京
- Year and Date
  2014-03-21
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Dantrolene may Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release within Ryanodine Receptor in Cardiac Troponin T-related Hypertrophic Cardiomyopathy2014
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第７8回日本循環器学会学術集会
- Place of Presentation
  東京、国際フォーラム
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Mapping the Binding Site of RyR2 “Unzipping” Peptide (DPc10) by Fluorescence Resonance Energy Transfer (FRET) in Permeabilized Cardiomyocytes2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第７8回日本循環器学会学術集会
- Place of Presentation
  東京、国際フォーラム
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Dantrolene may Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release within Ryanodine Receptor in Cardiac Troponin T-related Hypertrophic Cardiomyopathy2014
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Cardiomyocyte Ryanodine Receptor (RyR2) Oxidation in situ Causes Defective Interdomain Interaction and Reduces Calmodulin (CaM) Binding2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第７8回日本循環器学会学術集会
- Place of Presentation
  東京、国際フォーラム
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Dantrolene Corrects Aberrant Ca2+ Release and Improves Calmodulin Bindingto RyR2 in CPVT-associated Mutation2014
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Shinichi Okuda, Tetsurou Oda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  The 78th Annual scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  東京国際フォーラム,東京
- Year and Date
  2014-03-21
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] A Novel Selective EP4 Receptor Agonist Improves Cardiomyocyte Function by Inhibiting Ca2+ Leak through the Ryanodine Receptor in Failing Cardiomyocytes2014
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第７8回日本循環器学会学術集会
- Place of Presentation
  東京、国際フォーラム
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Enhanced Binding of Calmodulin to the Ryanodine Receptor Corrects Abnormal Calcium Handling in Pressure Over Loaded Heart Failure2014
- Author(s)
  Takayoshi Katoh, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myoren, Wakako Murakami, Masakazu Fukuda, Makoto Ohno, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Dantrolene may Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release within Ryanodine Receptor in Cardiac Troponin T-related Hypertrophic Cardiomyopathy2014
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Mapping the Binding Site of RyR2 “Unzipping” Peptide (DPc10) by Fluorescence Resonance Energy Transfer (FRET) in Permeabilized Cardiomyocytes2014
- Author(s)
  Tetsuro Oda, Takeshi Yamamoto, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第78回日本循環器学会学術集会
- Place of Presentation
  東京（東京国際フォーラム）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] A Novel Selective EP4 Receptor Agonist Improves Intracellular Ca^<2+> Handling and Cardiomyocyte Function in Intact Failing Cardiomyocytes2013
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas, (U.S.A)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Dantrolene May Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release Within the Ryanodine Receptor in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy2013
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas USA(Poster)
- Year and Date
  2013-11-16
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Dantrolene Inhibits Aberrant Ca2+ Release and Arrhythmogenesis via Enhancing Binding of Calmodulin to RyR2 in CPVT-Associated Mutation2013
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myouren, Takayoshi Katoh, Wakako Murakami, Makoto Ono, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas,Tx, USA
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] A Novel Selective EP4 Receptor Agonist Improves Intracellular Ca2+ Handling and Cardiomyocyte Function in Intact Failing Cardiomyocytes2013
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas(U. S. A)
- Year and Date
  2013-11-16
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Dantrolene May Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release Within the Ryanodine Receptor in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy2013
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] 急性心不全におけるカテコラミン誘発性心筋傷害に対するカルペリチドの心筋保護効果についての検討2013
- Author(s)
  村上和華子，小林茂樹，須佐建央，明連武樹，加藤孝佳，福田昌和，奥田真一，土居正浩，山本　健，矢野雅文
- Organizer
  第61回日本心臓病学会学術集会
- Place of Presentation
  熊本（ホテル日航熊本）
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Dissociation of Calmodulin from RyR2 Plays a Key Role in Diastolic Ca2+ Leak from Sarcoplasmic Reticulum in Pressure-overload Heart Failur2013
- Author(s)
  Takayoshi Katoh, Takeshi Yamamoto, Shigehiko Nishimura, Masakazu Fukuda, Makoto Ohno, Hiroki Tateishi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第17回日本心不全学会学術集会
- Place of Presentation
  埼玉（大宮ソニックシティ）
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Dantrolene May Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release Within the Ryanodine Receptor in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy2013
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas(U. S. A)
- Year and Date
  2013-11-16
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Dissociation of Calmodulin from RyR2 Plays a Key Role in Diastolic Ca2+ Leak from Sarcoplasmic Reticulum in Pressure-overload Heart Failure2013
- Author(s)
  Takayoshi Katoh, Takeshi Yamamoto, Shigehiko Nishimura, Masakazu Fukuda, Makoto Ohno, Hiroki Tateishi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  第17回日本心不全学会学術集会
- Place of Presentation
  埼玉（大宮ソニックシティ）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] カテコラミン誘発性多形性心室頻拍関連遺伝子変異を有する異常なリアノジン受容体において、カルモジュリン結合能改善は催不整脈性を抑制する2013
- Author(s)
  福田昌和，山本　健，加藤孝佳，村上和華子，立石裕樹，土居正浩，奥田真一，小林茂樹，矢野雅文
- Organizer
  第102回日本循環器学会中国・四国合同地方会
- Place of Presentation
  高松（サンポートホール高松）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Dantrolene Inhibits Aberrant Ca2+ Release and Arrhythmogenesis via Enhancing Binding of Calmodulin to RyR2 in CPVT-Associated Mutation2013
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myouren, Takayoshi Katoh, Wakako Murakami, Makoto Ono, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Dantrolene inhibits aberrant Ca2+ release by stabilizing inter-domain interactions within the ryanodine receptor in cardiac troponin T-related familial hypertrophic cardiomyopathy2013
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Akihiro Hino, Takayoshi Katoh, Masahiro Doi, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki, Masafumi Yano
- Organizer
  European Society of Cardiololgy Congress 2013
- Place of Presentation
  Amsterdam, Nederland
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Dantrolene Inhibits Aberrant Ca2+ Release and Arrhythmogenesis via Enhancing Binding of Calmodulin to RyR2 in CPVT-Associated Mutation2013
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myouren, Takayoshi Katoh, Wakako Murakami, Makoto Ono, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas USA(Oral)
- Year and Date
  2013-11-16
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] カテコラミン誘発性多形性心室頻拍関連の遺伝子変異を持つリアノジン受容体におけるカルモジュリンの効果について2013
- Author(s)
  福田昌和，山本　健，西村滋彦，明連武樹，加藤孝佳，村上和華子，大野　誠，小田哲郎，奥田真一，土居正浩，小林茂樹，矢野雅文
- Organizer
  第61回日本心臓病学会学術集会
- Place of Presentation
  熊本（ホテル日航熊本）
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] A Novel Selective EP4 Receptor Agonist Improves Intracellular Ca2+ Handling and Cardiomyocyte Function in Intact Failing Cardiomyocytes2013
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas,Tx, USA
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Dantrolene May Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release Within the Ryanodine Receptor in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy2013
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas, TX, USA
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] カテコラミン誘発性多形性心室頻拍関連の遺伝子変異を持つリアノジン受容体におけるカルモジュリンの効果について2013
- Author(s)
  福田昌和，山本　健，西村滋彦，明連武樹，加藤孝佳，村上和華子，大野　誠，小田哲郎，奥田真一，土居正浩，小林茂樹，矢野雅文
- Organizer
  第61回日本心臓病学会学術集会
- Place of Presentation
  熊本（ホテル日航熊本）
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Novel Selective EP4 Receptor Agonists Restore the Intracellular Ca2+ Handling and the Cardiomyocyte Function in Heart Failure2013
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Shinichi Okuda, Tetsuro Oda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  第17回日本心不全学会学術集会
- Place of Presentation
  埼玉（大宮ソニックシティ）
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Dantrolene Inhibits Aberrant Ca2+ Release and Arrhythmogenesis via Enhancing Binding of Calmodulin to RyR2 in CPVT-Associated Mutation2013
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myouren, Takayoshi Katoh, Wakako Murakami, Makoto Ono, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas, TX, USA
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] A Novel Selective EP4 Receptor Agonist Improves Intracellular Ca2+ Handling and Cardiomyocyte Function in Intact Failing Cardiomyocytes2013
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas, TX
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Dantrolene Inhibits Aberrant Ca2+ Release and Arrhythmogenesis via Enhancing Binding of Calmodulin to RyR2 in CPVT-Associated Mutation2013
- Author(s)
  Masakazu Fukuda, Takeshi Yamamoto, Shigehiko Nishimura, Takeki Myouren, Takayoshi Katoh, Wakako Murakami, Makoto Ono, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas(U. S. A)
- Year and Date
  2013-11-16
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] A Novel Selective EP4 Receptor Agonist Improves Intracellular Ca2+ Handling and Cardiomyocyte Function in Intact Failing Cardiomyocytes2013
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Takeki Myoren, Shigehiko Nishimura, Takayoshi Katoh, Masakazu Fukuda, Makoto Ono, Hiroki Tateishi, Mamoru Mochizuki, Tetsuro Oda, Shinichi Okuda, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas, USA
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Dantrolene May Suppress Arrhythmogenesis by Inhibition of CaMKII-mediated Aberrant Ca2+ Release Within the Ryanodine Receptor in Cardiac Troponin T-related Familial Hypertrophic Cardiomyopathy2013
- Author(s)
  Shinichi Okuda, Masakazu Fukuda, Takayoshi Katoh, Shigehiko Nishimura, Shigeki Kobayashi, Takeshi Yamamoto, Masafumi Yano
- Organizer
  86th Scientific Session of American Heart Association
- Place of Presentation
  Dallas,Tx, USA
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Elevated Myocardial Oxidative Stress Induced by Catecholamines Related to Transient Left Ventricular Cysfunction in Patients With Takotsubo Cardiomyopathy2012
- Author(s)
  Murakami W, Kobayashi S, Nakashima T,Tateishi H, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Okamura T,Yano M, Matsuzaki M
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Urinary 8-hydroxy-2'-deoxyguanosine, An Oxidative Stress Marker, Predicts The Inflammatory Activity within the Heart in Patients with Cardiac Sarcoidosis2012
- Author(s)
  Shigeki Kobayashi, Wakako Murakami, Seiko Fukuta, Masakazu Fukuda, Shinichi Okuda, Tomoko Nao, Masahiro Doi, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles, (U.S.A) (Oral)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Urinary 8-hydroxy-2' -deoxyguanosine, An Oxidative Stress Marker, Predicts The Inflammatory Activity within the Heart in Patients with Cardiac Sarcoidosi2012
- Author(s)
  Shigeki Kobayashi, Wakako Murakami, Seiko Fukuta, Masakazu Fukuda, Shinichi Okuda, Tomoko Nao, Masahiro Doi, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles(U. S. A)
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Elevated Myocardial Oxidative Stress Induced by Catecholamines Related to Transient Left Ventricular Cysfunction in Patients With Takotsubo Cardiomyopathy2012
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Tadamitsu Nakashima, Hiroki Tateishi, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Tomoko Nao, Jutaro Yamada, Takayuki Okamura, Masafumi Yano, Masunori Matsuzaki
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles(U. S. A)
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Fixing Ca^<2+> Leakage From Cardiac Ryanodine Receptor by Low-dose ofβBlocker Safely Enhances Inotropic Response to Milrinone in Acute Heart Failure2012
- Author(s)
  Shigeki Kobayashi, Wakako Murakami, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Hiroki Tateishi, Takeshi Yamamoto, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki
- Organizer
  5th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles, (U.S.A) (Oral)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Urinary 8-hydroxy-2' -deoxyguanosine as a Novel Marker of Left Ventricular Remodelling in Patients With Dilated Cardiomyopathy2012
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Takamasa Oda, Hiroki Tateishi, Tomoko Nao, Jutaro Yamada, Takayuki Okamura, Masafumi Yano, Masunori Matsuzaki
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles(U. S. A)
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Elevated Myocardial Oxidative Stress Induced by Catecholamines Related to Transient Left Ventricular Cysfunction in Patients With Takotsubo Cardiomyopathy2012
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Tadamitsu Nakashima, Hiroki Tateishi, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Tomoko Nao, Jutaro Yamada, Takayuki Okamura, Masafumi Yano, Masunori Matsuzaki
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles, (U.S.A) (Oral)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Fixing Ca2+ Leakage From Cardiac Ryanodine Receptor by Low-dose of β Blocker Safely Enhances Inotropic Response to Milrinone in Acute Heart Failure2012
- Author(s)
  Shigeki Kobayashi, Wakako Murakami, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Hiroki Tateishi, Takeshi Yamamoto, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Urinary 8-hydroxy-2'-deoxyguanosine, An Oxidative Stress Marker, Predicts The Inflammatory Activity within the Heart in Patients with Cardiac Sarcoidosis2012
- Author(s)
  Shigeki Kobayashi
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles, CA, USA
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Enhanced Binding of Calmodulin to RyR2 Inhibits Aberrant Ca2+ Release and Arrhythmogenesis in CPVT-Associated Mutation2012
- Author(s)
  Fukuda　M, Yamamoto　T, Kato T, Hino A, Suetomi T, Tateishi H, Doi M, Okuda S, Kobayashi S, Matsuzaki M, Yano M
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles(USA)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Fixing Ca2+ Leakage From Cardiac Ryanodine Receptor by Low-dose ofβBlocker Safely Enhances Inotropic Response to Milrinone in Acute Heart Failure2012
- Author(s)
  Shigeki Kobayashi, Wakako Murakami, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Hiroki Tateishi, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles USA(Oral)
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Urinary 8-hydroxy-2'-deoxyguanosine as a Novel Marker of Left Ventricular Remodelling in Patients With Dilated Cardiomyopathy2012
- Author(s)
  Wakako Murakami, Shigeki Kobayashi, Takamasa Oda, Hiroki Tateishi, Tomoko Nao, Jutaro Yamada, Takayuki Okamura, Masafumi Yano, Masunori Matsuzaki
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles, (U.S.A) (Poster)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Fixing Ca2+ Leakage From Cardiac Ryanodine Receptor by Low-dose of β Blocker Safely Enhances Inotropic Response to Milrinone in Acute Heart Failure2012
- Author(s)
  Shigeki Kobayashi
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Acceleration of the Early Diastolic Filing by Cardiac Re-synchronization is Important for Improving Symptoms of Severe Heart Failure2012
- Author(s)
  Shigeki Kobayashi
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles, CA, USA
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Fixing Ca2+ Leakage From Cardiac Ryanodine Receptor by Low-dose of β Blocker Safely Enhances Inotropic Response to Milrinone in Acute Heart Failure2012
- Author(s)
  Shigeki Kobayashi, Wakako Murakami, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Hiroki Tateishi, Takeshi Yamamoto, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles(U. S. A)
- Year and Date
  2012-11-03
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Urinary 8-hydroxy-2'-deoxyguanosine, An Oxidative Stress Marker, Predicts The Inflammatory Activity within the Heart in Patients with Cardiac Sarcoidosis2012
- Author(s)
  Shigeki Kobayashi, Wakako Murakami, Seiko Fukuta, Masakazu Fukuda, Shinichi Okuda, Tomoko Nao, Masahiro Doi, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki
- Organizer
  85th Scientific Session of American Heart Association
- Place of Presentation
  Los Angeles (USA)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Urinary 8-hydroxy-2'-deoxyguanosine as a Novel Biomarker of Inflammatory Activity in Patients with Cardiac Sarcoidosis : Insight From Immunohistochemical Technique and ^<18>F-FDG PET/CT2011
- Author(s)
  Seiko Fukuta, Shigeki Kobayashi, Takeo Tanaka, Takehisa Susa, Wakako Murakami, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Tomoko Nao, Jutaro Yamada, Takeshi Ueyama, Takayuki Okamura, Shuji Kawamura,Masafumi Yano, Masunori Matsuzaki
- Organizer
  84rd Scientific Session of American Heart Association
- Place of Presentation
  Orlando (U.S.A) (Poster) (Circulation.2011 ;124:A10269)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Low-dose of β blocker in combination with milrinone improve cardiac function in patients with acute decompensated heart failure2011
- Author(s)
  Shigeki Kobayashi
- Organizer
  European Society of Cardiololgy Congress
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-23390215
[Presentation] Coupled Conformational Changes in the Local and Global Inter-Domain Interactions Trigger Diastolic Ca2+ Release and Lethal Arrhythmia in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2011
- Author(s)
  Takeshi Suetomi; Masafumi Yano; Takayoshi Kato; Masakazu Fukuda; Akihiro Hino; Masahiro Doi; Shinichi Okuda; Shigeki Kobayashi; Yasuhiro Ikeda; Takeshi Yamamoto; Masunori Matsuzaki
- Organizer
  84rd Scientific Session of American Heart Association
- Place of Presentation
  Orland, FL, USA
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Enhancement of Calmodulin Binding to RyR2 Inhibits Aberrant Ca2+ Release in CPVT-Associated Mutation2011
- Author(s)
  Masakazu Fukuda, Masafumi Yano, Takayoshi Kato, Akihiro Hino, Takeshi Suetomi, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Masunori Matsuzaki
- Organizer
  84rd Scientific Session of American Heart Association
- Place of Presentation
  Orland, FL, USA
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Low-dose of β blocker in combination with milrinone improve cardiac function in patients with acute decompensated heart failure2011
- Author(s)
  Shigeki Kobayashi, Takehisa Susa,Tanaka Takeo, Wakako Murakami, Shinichi Okuda, Masahiro Doi, Tomoko Nao, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki
- Organizer
  European Society of Cardiololgy Congress 2011
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Low-dose ofβblocker in combination with milrinone improve cardiac function in patients with acute decompensated heart failure2011
- Author(s)
  Shigeki Kobayashi, Takehisa Susa,Tanaka Takeo, Wakako Murakami, Shinichi Okuda, Masahiro Doi, Tomoko Nao, Yasuaki Wada, Masafumi Yano, Masunori Matsuzaki
- Organizer
  European Society of Cardiololgy Congress 2011
- Place of Presentation
  Paris(France)(Eur Heart J32[Suppl 1] :785)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Urinary 8-hydroxy-2'-deoxyguanosine as a Novel Biomarker of Inflammatory Activity in Patients with Cardiac Sarcoidosis: Insight From Immunohistochemical Technique and 18F-FDG PET/CT2011
- Author(s)
  Fukuta S, Kobayashi S, Tanaka T, Susa T, Murakami W, Okuda S, Doi M, Wada Y, Nao T, Yamada J, Ueyama T, Okamura T, Kawamura S, Yano M, Matsuzaki M
- Organizer
  84rd Scientific Session of American Heart Association
- Place of Presentation
  Orland, FL, USA
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Ryanodine receptor-targeting therapy against heart failure and lethal arrhythmia2011
- Author(s)
  Shigeki Kobayashi, Masafumi Yano, Takeshi Yamamoto, Masunori Matsuzaki
- Organizer
  The 28th Annual Meeting of the International Society for Heart Research Japanese Section(招待講演)
- Place of Presentation
  The National Center of Science Building, Tokyo
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Enhancement of Calmodulin Binding to RyR2 Inhibits Aberrant Ca2+ Release in CPVT-Associated Mutation2011
- Author(s)
  Masakazu Fukuda, Masafumi Yano, Takayoshi Kato, Akihiro Hino, Takeshi Suetomi, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Masunori Matsuzaki
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  Florida (USA)
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Ryanodine receptor-targeting therapy against heart failure and lethal arrhythmia2011
- Author(s)
  Shigeki Kobayashi, Masafumi Yano,Takeshi Yamamoto, Masunori Matsuzaki
- Organizer
  The 28th Annual Meeting of the International Society for Heart Research Japanese Section
- Place of Presentation
  The National Center of Science Building(Tokyo) (Symposium)
- Data Source
  KAKENHI-PROJECT-23592256
[Presentation] Coupled Conformational Changes in the Local and Global Inter-Domain Interactions Trigger Diastolic Ca2+ Release and Lethal Arrhythmia in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2011
- Author(s)
  Takeshi Suetomi, Masafumi Yano, Takayoshi Kato, Masakazu Fukuda, Akihiro Hino, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Masunori Matsuzaki
- Organizer
  American Heart Association Scientific Sessions 2011
- Place of Presentation
  Florida (USA)
- Data Source
  KAKENHI-PROJECT-23591082
[Presentation] Correction of Defective Calmodulin Binding to Cardiac Ryanodine Receptor Inhibits Aberrant Ca2+ Release in CPVT-associated Mutation.2010
- Author(s)
  Masakazu Fukuda, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Xiaojuan Xu, Makoto Ono, Hitoshi Uchinoumi, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki.
- Organizer
  83rd Scientific Session of American Heart Association.
- Place of Presentation
  Chicago, USA.
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Correction of the defective inter-domain interaction within ryanodine receptor prevents the development of heart failure.2010
- Author(s)
  Hitoshi Uchinoumi, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Xiaojuan Xu, Makoto Ohno, Shinichi Okuda, MasahiroDoi, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki.
- Organizer
  20th World Congress of the International Society for Heart Research.
- Place of Presentation
  京都,京都国際会議場
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Correction of Defective Conformational Regulation of the Cardiac Ryanodine Receptor is a New Therapeutic Strategy against Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT).2010
- Author(s)
  Hitoshi Uchinoumi, Masafumi Yano, Takeshi Suetomi, Makoto Ohno, Xiaojuan Xu, Hiroki Tateishi, Tetsuro Oda, Shinichi Okuda, Masahiro Doi, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Tomoko Ohkusa, Masunori Matsuzaki.
- Organizer
  The 74th Annual Scientific Meeting of the Japanese Circulation Society.
- Place of Presentation
  京都,京都国際会議場
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Increased Affinity of Calmodulin Binding to Cardiac Ryanodine Receptor Corrects the Defective Channel Gating in Failing Hearts.2010
- Author(s)
  Akihiro Hino, Masafumi Yano, Masakazu Fukuda, Takeshi Suetomi, Makoto Ono, Xiaojuan Xu, Hitoshi Uchinoumi, Takehisa Susa, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki.
- Organizer
  83rd Scientific Session of American Heart Association.
- Place of Presentation
  Chicago, USA.
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Masunori Matsuzaki Urinary 8-Hydroxy-2'-Deoxyguanosine is a Biomarker for Evaluating the Inflammatory Activity and the Effectiveness to Corticosteroids in Patients with Cardiac Sarcoidosis.2010
- Author(s)
  Takeo Tanaka, Shigeki Kobayashi, Takehisa Susa, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Jutaro Yamada, Takeshi Ueyama, Takayuki Okamura, Shuji Kawamura, Masafumi Yano
- Organizer
  83rd Scientific Session of American Heart Association.
- Place of Presentation
  Chicago, USA.
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Risk Stratification of Chronic Heart Failure by the Combination of Urinary 8-Hydroxy-2'-Deoxyguanosine and Plasma Brain Natriuretic Peptide.2010
- Author(s)
  Takehisa Susa, Shigeki Kobayashi, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Jutaro Yamada, Takayuki Okamura, Takeshi Ueyama, Masafumi Yano, Masunori Matsuzaki.
- Organizer
  The 14th Annual Scientific Meeting of the Japanese Heart Failure Society.
- Place of Presentation
  東京京王プラザホテル
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Interruption of Novel Inter-domain Interaction Within RyR2 as a Common Therapeutic Target by Channel Stabilization in Heart Failure and Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2010
- Author(s)
  Takeshi Yamamoto, Masafumi Yano, Masahiro Fukuda, Akihiro Hino, Takeshi Suetomi, Masahiro Doi, Shinich Okuda, Shigeki Kobayashi, Masunori Matsuzaki
- Organizer
  American Heart Association Scientific Sessions
- Place of Presentation
  Chicago IL, USA
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20590868
[Presentation] Urine 8-hydroxy-2'-deoxyguanosine is a Marker for Predicting Mortality and Morbidity as well as Evaluating the Effectiveness of Beta-blocker Therapy in Patients with Chronic Heart Failure.2010
- Author(s)
  Takehisa Susa, Shigeki Kobayashi, Takeo Tanaka, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Jutaro Yamada, Takeshi Ueyama, Shuji Kawamura, Masafumi Yano, Masunori Matsuzaki.
- Organizer
  59th Annual Scientific Session of the American College of Cardiology.
- Place of Presentation
  Atlanta, USA.
- Year and Date
  2010-03-15
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Mutation-linked Defective Domain Interaction within the Ryanodine Receptor Causes Ca2+ Leak Leading to Catecholaminergic Polymorphic Ventricular Tachycardia.2010
- Author(s)
  Takeshi Suetomi, Masafumi Yano, Masakazu Fukuda, Akihiro Hino, Makoto Ono, Xiaojuan Xu, Takehisa Susa, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Masunori Matsuzaki.
- Organizer
  83rd Scientific Session of American Heart Association.
- Place of Presentation
  Chicago, USA.
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Mechanism of Destabilized RyR2 Channel in Catecholaminergic Polymorphic Ventricular Tachycardia.2010
- Author(s)
  Takeshi Suetomi, Masafumi Yano, Makoto Ohno, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Masahiro Doi, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Masunori Matsuzaki.
- Organizer
  The 14th Annual Scientific Meeting of the Japanese Heart Failure Society.
- Place of Presentation
  東京京王プラザホテル
- Year and Date
  2010-10-07
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Interruption of Novel Inter-domain Interaction within RyR2 as a Common Therapeutic Target for Channel Stabilization in Heart Failure and CPVT.2010
- Author(s)
  Takeshi Yamamoto, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Makoto Ohno, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Masahiro Doi, Shigeki Kobayashi, Masunori Matsuzaki.
- Organizer
  The 74th Annual Scientific Meeting of the Japanese Circulation Society.
- Place of Presentation
  京都,京都国際会議場
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Urinary 8-Hydroxy-2'Deoxyguanosine as an Oxidative Stress Biomarker in Patients with Chronic Heart Failure.2010
- Author(s)
  Shigeki Kobayashi, Takehisa Susa, Takeo Tanaka, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Yasuhiro Yoshiga, Jutaro Yamada, Takeshi Ueyama, Shuji Kawamura, Masafumi Yano, Masunori Matsuzaki.
- Organizer
  The 74th Annual Scientific Meeting of the Japanese Circulation Society.
- Place of Presentation
  京都,京都国際会議場
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Novel Inter-domain Interaction Within RyR2 as a Common Therapeutic Target by Channel Stabilization in Heart Failure and in Heart Failure and Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT).2010
- Author(s)
  Masafumi Yano, Masakazu Fukuda, Akihiro Hino, Takeshi Suetomi, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Masunori Matsuzaki.
- Organizer
  83rd Scientific Session of American Heart Association.
- Place of Presentation
  Chicago, USA.
- Year and Date
  2010-11-15
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Decreased Affinity of Calmodulin to the Cardiac Ryanodine Receptor Plays a Crucial Role in the CPVT-type Channel Disorder.2010
- Author(s)
  Xiaojuan Xu, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Makoto Ohno, Hitoshi Uchinoumi, Tetsuro Oda, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Tomoko Ohkusa, Masunori Matsuzaki.
- Organizer
  74th Annual Scientific Meeting of the Japanese Circulation Society.
- Place of Presentation
  京都,京都国際会議場
- Year and Date
  2010-03-05
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Correction of defective inter-domain interaction within the cardiac ryanodine receptor as a new therapeutic strategy against catecholaminergic polymorphic ventricular tachycardia (CPVT).2009
- Author(s)
  Hitoshi Uchinoumi, Masafumi Yano, Takeshi Suetomi, Makoto Ohno, Xiaojuan Xu, Shigeki Kobayashi, Takeshi Yamamoto, Masunori Matsuzaki.
- Place of Presentation
  札幌,ロイトン札幌
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Urine 8-hydroxy-2'-deoxyguanosine is Well Correlated With Cardiac Dysfunction and Poor Prognosis in Chronic Heart Failure Patients.2009
- Author(s)
  Takehisa Susa, Shigeki Kobayashi, Takeo Tanaka, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Yomoko Nao, Yasuhiro Yoshiga, Jutaro Yamada, Shuji Kawamura, Masafumi Yano, Masunori Matsuzaki.
- Organizer
  82nd Scientific Session of American Heart Association.
- Place of Presentation
  Orlando, USA.
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Low-dose of β Blocker Improves Cardiac Function in Patients With Acute Heart Failure Partly by Inhibiting Ca2+ Leak Through the Ryanodine Receptor.2009
- Author(s)
  Shigeki Kobayashi, Takeo Tanaka, Takehisa Susa, Makoto Ohno, Hitoshi Uchinoumi, Shinichi Okuda, Masahiro Doi, Shuji Kawamura, Takeshi Yamamoto, Masafumi Yano, Masunori Matsuzaki.
- Organizer
  82nd Scientific Session of American Heart Association.
- Place of Presentation
  Orlando, USA.
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Dantrolene Prevents Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)by Correcting Abnormal Ca^<2+>Release through the Ryanodine Receptor2009
- Author(s)
  Shigeki Kobayashi
- Organizer
  The 73nd Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Osaka, Japan
- Year and Date
  2009-03-22
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Urine 8-hydroxy-2'-deoxyguanosine as a New Biomarker of Inflammatory Activity in Patients With Cardiac Sarcoidosis.2009
- Author(s)
  Takeo Tanaka, Shigeki Kobayashi, Takehisa Susa, Shinichi Okuda, Masahiro Doi, Yasuaki Wada, Tomoko Nao, Yasuhiro Yoshiga, Jutaro Yamada, Shuji Kawamura, Masafumi Yano, Masunori Matsuzaki.
- Organizer
  82nd Scientific Session of American Heart Association.
- Place of Presentation
  Orlando, USA.
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Decreased Affinity of Calmodulin to RyR2 May Be a Sauce Mechanism of Leaky Channel in CPVT-associated Mutation.2009
- Author(s)
  Xiaojuan Xu, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Makoto Ohno, Hitoshi Uchinoumi, Tetsuro Oda, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Tomoko Ohkusa, Masunori Matsuzaki.
- Organizer
  82nd Scientific Session of American Heart Association.
- Place of Presentation
  Orlando, USA.
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Low-dose of β blocker improves cardiac function in patients with acute heart failure partly by inhibiting Ca2+leak through ryanodine receptor.2009
- Author(s)
  Shigeki Kobayashi
- Organizer
  Scientific Sessions 2009 of American Heart Association
- Place of Presentation
  Orland, USA
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Correction of Defective Inter-domain Interaction Within the Cardiac Ryanodine Receptor as a New Therapeutic Strategy Against Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT).2009
- Author(s)
  Hitoshi Uchinoumi, Masafumi Yano, Akihiro Hino, Takeshi Suetomi, Makoto Ohno, Xiaojuan Xu, Tetsuro Oda, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Yasuhiro Ikeda, Masunori Matsuzaki.
- Organizer
  82nd Scientific Session of American Heart Association.
- Place of Presentation
  Orlando, USA.
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Low-dose βblocker therapy improves cardiac function in patients with acute heart failure partly through correction of abnormal intracellular Ca2+ handling2009
- Author(s)
  Shigeki Kobayashi
- Organizer
  The American College of Cardiology 58^<th> Annual Scientific Session
- Place of Presentation
  Orlando, USA
- Year and Date
  2009-03-29
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Mutation-linked Channel Disorder in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is Caused by Abnormally Tight Domain-Domain Interaction in RyR2.2009
- Author(s)
  Takeshi Suetomi, Masafumi Yano, Akihiro Hino, Makoto Ohno, Xiaojuan Xu, Takehisa Susa, Hitoshi Uchinoumi, Tetsuro Oda, Masahiro Doi, Shinichi Okuda, Shigeki Kobayashi, Yasuhiro Ikeda, Takeshi Yamamoto, Masunori Matsuzaki.
- Organizer
  82nd Scientific Session of American Heart Association.
- Place of Presentation
  Orlando, USA.
- Year and Date
  2009-11-16
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Identification of Target Domains of the Cardiac Ryanodine Receptor to Correct Channel Disorder in Failing Hearts2008
- Author(s)
  Yamamoto, T, Yano, M, Suedomi, T, Ohno, M, Xu, XJ, Tateishi, H, Okuda, S, Kobayashi, S, Ikeda, Y, Matsuzaki, M
- Organizer
  Basic Cardiovascular Sciences Annual Conference 2009-Molecular Mechanisms of Cardiovascular Disease.
- Place of Presentation
  Keystone, USA
- Data Source
  KAKENHI-PROJECT-20590868
[Presentation] Dantrolene,a therapeutic agent for malignant hyperthermia,inhibits cathecholaminergic polymorphic ventricular tachycardia:Insights from a RyR2 R2474S/+knock-in mouse model2008
- Author(s)
  小林茂樹
- Organizer
  第72回日本循環器学会総会・学術集会
- Place of Presentation
  福岡
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18591706
[Presentation] Dantrolene, a Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia: Insights from a RyR2 R2474S/+ Knock-in Mouse Model2008
- Author(s)
  Shigeki Kobayashi
- Organizer
  The 72nd Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2008-03-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591706
[Presentation] Domain2114-2149 Within RyR2 Plays a Key Role for Correcting Channel Disorder in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)2008
- Author(s)
  Yamamoto, T, Yano, M, Suedomi, T, Ohno, M, Xu, XJ, Tateishi, H, Okuda, S, Kobayashi, S, Ikeda, Y, Matsuzaki, M
- Organizer
  Scientific Sessions 2008 of American Heart Association
- Place of Presentation
  NewOrleans, USA
- Data Source
  KAKENHI-PROJECT-20590868
[Presentation] Dantrolene inhibits spontaneous Ca^<2+> release as a substrate for catecholaminergic polymorphic ventricular tachycardia (CPVT)by correcting defective inter-domain interaction within the ryanodine receptor2008
- Author(s)
  Shigeki Kobayashi
- Organizer
  Scientific Sessions 2008 of American Heart Association
- Place of Presentation
  New Orleans, USA
- Year and Date
  2008-11-12
- Data Source
  KAKENHI-PROJECT-20591805
[Presentation] Correction of Defective Inter-Domain Interactions within Ryanodine Recepter by Dantrolene May be a Potent Therapeutic Strategy against Lethal Arrhythmia2007
- Author(s)
  Shigeki Kobayashi
- Organizer
  The 71st Annual Scientific Meeting of the Japanese Circulation Society
- Place of Presentation
  Kobe, Japan
- Year and Date
  2007-03-16
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591706
[Presentation] Dantrolene, A Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia: Insights from a RyR2R2474S/+Knock-in Mouse Model2007
- Author(s)
  Shigeki Kobayashi
- Organizer
  Scientific Sessions 2007 of American Heart Association
- Place of Presentation
  Orland, USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591706
[Presentation] Dantrolene, A Therapeutic Agent for Malignant Hyperthermia, Inhibits Catecholaminergic Polymorphic Ventricular Tachycardia : Insights from a RyR2R2474S/+Knock-in Mouse Model2006
- Author(s)
  Shigeki, Kobayashi, Masafumi, Yano, Hitoshi, Uchinoumi, Xiaojuan, Xu, Makoto, Ohno, Hiroki, Tateishi, Takeshi, Yamamoto, Masunori, Matsuzaki
- Organizer
  Scientific Sessions 2006 of American Heart Association
- Place of Presentation
  Orland
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591706
[Presentation] Correction of Defective Inter-Domain Interacitons within Ryanodine Recepter by Dantrolene may be a Potent Therapeutic Strategy Against Lethal Arrhythmia2006
- Author(s)
  Shigeki, Kobayashi, Masafumi, Yano, Takeshi, Yamamoto, Xu, Xiaojuan, Makoto, Ono, Hitoshi, Uchinoumi, Hiroki, Tateishi, Mamoru, Mochizuki, Toshiyuki, Noma
- Organizer
  Scientific Sessions 2006 of American Heart Association
- Place of Presentation
  Chicago
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591706
[Presentation] Stabilization of Ryanodine Receptor by Dantrolene may be a Potent Therapeutic Strategy Against Lethal Arrhythmia2006
- Author(s)
  Shigeki Kobayashi
- Organizer
  The 10th Annual Scientific Meeting of the Japanese Heart Failure Soiety
- Place of Presentation
  Tokyo, Japan
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591706
[Presentation] Correction of Defective Inter-Domain Interacitons within Ryanodine Recepter by Dantrolene may be a Potent Therapeutic Strategy Against Lethal Arrhythmia2006
- Author(s)
  Shigeki Kobayashi
- Organizer
  Scientific Sessions 2006 of American Heart Association
- Place of Presentation
  Chicago, USA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591706

1. YAMAMOTO Takeshi (50363122)

# of Collaborated Projects: 12 results

# of Collaborated Products: 131 results
2. YANO Masafumi (90294628)

# of Collaborated Projects: 11 results

# of Collaborated Products: 172 results
3. 小田哲郎 (40569290)

# of Collaborated Projects: 6 results

# of Collaborated Products: 42 results
4. IKEDA Yasuhiro (00260349)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. Mizukami Yoichi (80274158)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. 森本幸生 (50202362)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 大塚正人 (90372945)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YOSHIGA Yasuhiro (00423393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 小室拓也 (00760787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 上山剛 (60380010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 清水昭彦 (70263762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 諌山慧士朗 (30780887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 渡邉健司 (50711264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 中村吉秀 (80933481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 堀居拓郎 (00361387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 三浦史仁 (50447348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 岡村誉之 (70380011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 南和幸 (00229759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 末冨建 (40749842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. OKUDA Shinichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. OKADA Munemasa

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. HONDA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. YAMAMOTO Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. TANI Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. FUJISAWA Koichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 朝霧成挙

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 酒井大樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 高見太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 名和田隆司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 大野誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 小室一成

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Shigeki 小林 茂樹

KOBAYASHI Shigeki 小林 茂樹

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Development of RyR2-targetting therapy for heart failure and arrhythmiaPrincipal Investigator

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リアノジン受容体を分子標的とした心不全・不整脈の新たな治療開発Principal Investigator

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Targetting ryanodine receptors for anti-heart failure and anti-arrhythmic therapyPrincipal Investigator

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Ryanodine receptor-targeting therapy for heart failure and lethal arrhythmiaPrincipal Investigator

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Kobayashi Shigeki 小林茂樹

KOBAYASHI Shigeki 小林茂樹

[Book] メディカル・サイエンス・ダイジェスト　心不全 Up to Date2019