Tazawa Hiroshi 田澤大

… Alternative Names

TAZAWA Hiroshi 田澤大

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Researcher Number	90415513
Other IDs	https://orcid.org/0000-0003-4658-1050
Affiliation (Current)	2024: 岡山大学, 大学病院, 准教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 岡山大学, 大学病院, 准教授 2015: 岡山大学, 大学病院消化器外科, 助教 2011 – 2015: 岡山大学, 大学病院, 助教 2013: 岡山大学, 助教 2013: 岡山大学, 病院, 助教 2012: 岡山大学, 岡山大学病院, 助教 2010: 岡山大学, 岡山大学病院, 助教
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 50020:Tumor diagnostics and therapeutics-related / Thoracic surgery Except Principal Investigator Digestive surgery / Basic Section 56020:Orthopedics-related / Basic Section 55020:Digestive surgery-related / Laboratory medicine
Keywords	Principal Investigator アデノウイルス / マイクロRNA / p53 / 膵臓癌 / KRAS / オートファジー / 個別化治療 / 代謝サブタイプ / 神経関連因子 / 免疫原性細胞死 … More / 腫瘍融解 / EGFR / BRAF / 大腸癌 / テロメラーゼ / 癌 … More Except Principal Investigator 消化器癌 / 癌 / トランスレーショナル・リサーチ / トランスレーショナルリサーチ / 医療・福祉 / 細胞・組織 / 遺伝子 / 癌微小環境 / 腹膜播種 / 胃癌 / 膵癌 / 大腸癌 / 遺伝子解析 / アデノウイルス / 腫瘍融解ウイルス / ウイルス療法 / 原発性脊椎腫瘍 / 脊椎脊髄腫瘍 / ウイルス治療 / 蛍光発現ウイルス / 抗転移薬剤 / アスピリン / EMT / 蛍光イメージング / 転移 / 腫瘍関連マクロファージ / 腹腔内遊離癌細胞 / 腫瘍微小環境 / 抗癌剤抵抗性 / マクロファージ / ﾄﾗﾝｽﾚｰｼｮﾅﾙ・ﾘｻｰﾁ / トランス / 放射線療法 / 化学療法 / 近赤外線光 / 線維芽細胞 / 食道癌 / 光線免疫療法 / がん微小環境 / 治療抵抗性 / CAF / 癌関連線維芽細胞 / Photoimmunotherapy / 近赤外光線免疫療法 / 近赤外線光線免疫療法 / HER2 / 光免疫療法 / p53 / 悪性化進展 / 微小環境 / 慢性炎症 / 血中浮遊腫瘍細胞(CTC) / 消化管間質腫瘍(GIST) / PKC / FHIT / 転移・浸潤 / 遺伝子治療 / 循環腫瘍細胞 / 蛍光 / 末梢血循環腫瘍細胞 Less

原発性脊椎腫瘍に対する腫瘍融解ウイルス療法の確立
- Principal Investigator
  
  鷹取亮
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
脊椎脊髄腫瘍に対する腫瘍融解ウイルス療法の確立
- Principal Investigator
  
  魚谷弘二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
Immune molecular mechanism for enhancing antitumor potency of a next-generation oncolytic virus by pre-immunization
- Principal Investigator
  
  藤原俊義
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Exploration of metabolic factors to inhibit tumor-specific p53 gene therapy in pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  田澤大
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Okayama University
Development of a next-generation viral agent targeting immunosuppression by crosstalk in the pancreatic cancer microenvironment
- Principal Investigator
  
  Fujiwara Toshiyoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Okayama University
Imaging system for progression of gastrointestinal cancer and its application to anti-metastasis therapy
- Principal Investigator
  
  Nishizaki Masahiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Development of the Dual fluorescent cytology with tumor-specific viruses for gastrointestinal cancer precision medicine
- Principal Investigator
  
  FUJIWARA Toshiyoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Preclinical study of tumor-specific p53 gene therapy against refractory pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  TAZAWA HIROSHI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Analysis for intraperitoneal cancer microenvironment to elucidate the biological mechanism of peritoneal metastasis of gastrointestinal cancer
- Principal Investigator
  
  Shunsuke Kagawa
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Laboratory medicine
- Research Institution
  Okayama University
Development of anti-metastasis therapy in the inflammation-related gastric cancer progression
- Principal Investigator
  
  NISHIZAKI MASAHIKO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Novel targeting therapy to cancer-associated fibroblasts for treatment-resistant carcinomas
- Principal Investigator
  
  Noma Kazuhiro
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Development of novel microRNA-based therapy against KRAS/BRAF-mutant colorectal cancerPrincipal Investigator
- Principal Investigator
  
  TAZAWA HIROSHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Photoimmunotherapy for gastrointestinal cancer
- Principal Investigator
  
  Tanabe Shunsuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Fluorescence-guided detection and genetic analysis of circulating tumor cells
- Principal Investigator
  
  KAGAWA Shunsuke
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Tumor suppressor FHIT regulates tumor invasion of pancreatic cancer cells via inhibiting association of Ezrin and Actin cytoskeleton
- Principal Investigator
  
  NISHIZAKI Masahiko
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Circulating Tumor Cell of Gastrointestinal Stromal Tumor
- Principal Investigator
  
  UNO Futoshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Okayama University
Induction of autophagic cell death via microRNA-mediated gene regulatory networkPrincipal Investigator
- Principal Investigator
  
  TAZAWA Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Okayama University

[Book] Advances in Medicine and Biology. Volume 1102017
- Author(s)
  Tazawa H, Kagawa S, Shigeyasu K, Fujiwara T
- Total Pages
  226
- Publisher
  Nova Science Publishers
- Data Source
  KAKENHI-PROJECT-16K10596
[Book] Advances in Medicine and Biology. Volume 1102017
- Author(s)
  Tazawa H, Kagawa S, Shigeyasu K, Fujiwara T
- Total Pages
  226
- Publisher
  Nova Science Publishers
- Data Source
  KAKENHI-PROJECT-26461978
[Book] 次世代がん治療（第3章第1節）2017
- Author(s)
  田澤　大、田辺俊介、香川俊輔、白川靖博、藤原俊義
- Total Pages
  347
- Publisher
  エヌ・ティー・エス
- ISBN
  4860435036
- Data Source
  KAKENHI-PROJECT-16K10596
[Book] Recent Results in Cancer Research (Current Strategies in Cancer Gene Therapy)2016
- Author(s)
  Tazawa H, Kagawa S, Fujiwara T
- Total Pages
  121
- Publisher
  Springer International Publishing
- Data Source
  KAKENHI-PROJECT-16K10596
[Book] Recent Results in Cancer Research (Current Strategies in Cancer Gene Therapy)2016
- Author(s)
  Tazawa H, Kagawa S, Fujiwara T
- Total Pages
  121
- Publisher
  Springer International Publishing
- Data Source
  KAKENHI-PROJECT-26461978
[Book] Tumor Suppressor Genes: Functions, Regulation and Health Effects2013
- Author(s)
  Tazawa H, Kagawa S, Fujiwara T
- Total Pages
  373
- Publisher
  Nova Science Publishers
- Data Source
  KAKENHI-PROJECT-25462057
[Journal Article] Oncolytic virus-mediated reducing of myeloid-derived suppressor cells enhances the efficacy of PD-L1 blockade in gemcitabine-resistant pancreatic cancer2023
- Author(s)
  Kajiwara Y, Tazawa H, Yamada S, Kanaya N, Fushimi T, Kikuchi S, Kuroda S, Ohara T, Noma K, Yoshida R, Umeda Y, Urata Y, Kagawa S, Fujiwara T
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 72 Issue: 5 Pages: 1285-1300
- DOI
  10.1007/s00262-022-03334-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07219, KAKENHI-PROJECT-22K08775
[Journal Article] Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment2022
- Author(s)
  Sato Hiroaki、Noma Kazuhiro、Ohara Toshiaki、Kawasaki Kento、Akai Masaaki、Kobayashi Teruki、Nishiwaki Noriyuki、Narusaka Toru、Komoto Satoshi、Kashima Hajime、Katsura Yuki、Kato Takuya、Kikuchi Satoru、Tazawa Hiroshi、Kagawa Shunsuke、Shirakawa Yasuhiro、Kobayashi Hisataka、Fujiwara Toshiyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 20152-20152
- DOI
  10.1038/s41598-022-24313-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K24407
[Journal Article] Modulation of cancer-associated fibroblasts by oncolytic adenovirus-mediated p53 gene therapy overcomes peritoneal metastasis of gastric cancer2022
- Author(s)
  Ogawa T, Kikuchi S, Tabuchi M, Mitsui E, Une Y, Tazawa H, Kuroda S, Noma K, Ohara T, Kagawa S, Urata Y, Fujiwara T
- Journal Title
  
  Mol Ther Oncolytics
  
  Volume: 25 Pages: 249-261
- DOI
  10.1016/j.omto.2022.04.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07219, KAKENHI-PROJECT-23K24407
[Journal Article] Oncolytic virus-mediated p53 overexpression promotes immunogenic cell death and efficacy of PD-1 blockade in pancreatic cancer2022
- Author(s)
  Araki H, Tazawa H, Kanaya N, Kajiwara Y, Yamada M, Hashimoto M, Kikuchi S, Kuroda S, Yoshida R, Umeda Y, Urata Y, Kagawa S, Fujiwara T
- Journal Title
  
  Mol Ther Oncolytics
  
  Volume: 27 Pages: 3-13
- DOI
  10.1016/j.omto.2022.09.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07219, KAKENHI-PROJECT-22K08775, KAKENHI-PROJECT-23K24407
[Journal Article] Tumor‐targeted fluorescence labeling systems for cancer diagnosis and treatment2022
- Author(s)
  Tazawa H、Shigeyasu K、Noma K、Kagawa S、Sakurai F、Mizuguchi H、Kobayashi H、Imamura T、Fujiwara T
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 6 Pages: 1919-1929
- DOI
  10.1111/cas.15369
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07219, KAKENHI-PROJECT-21H03056, KAKENHI-PROJECT-23K24407
[Journal Article] Overexpression of Adenovirus E1A Reverses Transforming Growth Factor-β-induced Epithelial-mesenchymal Transition in Human Esophageal Cancer Cells2022
- Author(s)
  Masuda T, Tazawa H, Hashimoto Y, Ieda T, Kikuchi S, Kuroda S, Noma K, Urata Y, Kagawa S, Fujiwara T
- Journal Title
  
  Acta Medica Okayama
  
  Volume: 76 Issue: 2 Pages: 203-215
- DOI
  10.18926/AMO/63425
- URL
  https://ousar.lib.okayama-u.ac.jp/63425
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07219, KAKENHI-PROJECT-23K24407
[Journal Article] Nanog is a promising chemoresistant stemness marker and therapeutic target by iron chelators for esophageal cancer2021
- Author(s)
  Toru Narusaka, Toshiaki Ohara, Kazuhiro Noma, Noriyuki Nishiwaki, Yuki Katsura, Takuya Kato, Hiroaki Sato, Yasuko Tomono, Satoru Kikuchi, Hiroshi Tazawa, Yasuhiro Shirakawa, Akihiro Matsukawa, Toshiyoshi Fujiwara
- Journal Title
  
  International Journal of Cancer
  
  Volume: - Issue: 2 Pages: 347-357
- DOI
  10.1002/ijc.33544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08539, KAKENHI-PROJECT-19H03731
[Journal Article] Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation2021
- Author(s)
  Ito Atene、Kagawa Shunsuke、Sakamoto Shuichi、Kuwada Kazuya、Kajioka Hiroki、Yoshimoto Masashi、Kikuchi Satoru、Kuroda Shinji、Yoshida Ryuichi、Tazawa Hiroshi、Fujiwara Toshiyoshi
- Journal Title
  
  BMC Cancer
  
  Volume: 21 Issue: 1 Pages: 102-114
- DOI
  10.1186/s12885-021-07816-6
- NAID
  120006980466
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08679, KAKENHI-PROJECT-19H03731
[Journal Article] Fibroblast activation protein targeted near infrared photoimmunotherapy (NIR PIT) overcomes therapeutic resistance in human esophageal cancer2021
- Author(s)
  Katsube Ryoichi、Noma Kazuhiro、Ohara Toshiaki、Nishiwaki Noriyuki、Kobayashi Teruki、Komoto Satoshi、Sato Hiroaki、Kashima Hajime、Kato Takuya、Kikuchi Satoru、Tazawa Hiroshi、Kagawa Shunsuke、Shirakawa Yasuhiro、Kobayashi Hisataka、Fujiwara Toshiyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 1693-1693
- DOI
  10.1038/s41598-021-81465-4
- NAID
  120006961122
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03731
[Journal Article] Phase I dose-escalation study of endoscopic intratumoral injection of OBP-301 (Telomelysin) with radiotherapy in oesophageal cancer patients unfit for standard treatments2021
- Author(s)
  Shirakawa Y、Tazawa H、Tanabe S、Kanaya N、Noma K、Koujima T、Kashima H、Kato T、Kuroda S、Kikuchi S、Kagawa S、Katsui K、Kanazawa S、Urata Y、Fujiwara T
- Journal Title
  
  European Journal of Cancer
  
  Volume: 153 Pages: 98-108
- DOI
  10.1016/j.ejca.2021.04.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07219
[Journal Article] Oncolytic virotherapy promotes radiosensitivity in soft tissue sarcoma by suppressing anti-apoptotic MCL1 expression2021
- Author(s)
  Omori Toshinori、Tazawa Hiroshi、Yamakawa Yasuaki、Osaki Shuhei、Hasei Joe、Sugiu Kazuhisa、Komatsubara Tadashi、Fujiwara Tomohiro、Yoshida Aki、Kunisada Toshiyuki、Urata Yasuo、Kagawa Shunsuke、Ozaki Toshifumi、Fujiwara Toshiyoshi
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 4 Pages: e0250643-e0250643
- DOI
  10.1371/journal.pone.0250643
- NAID
  120007045007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03731
[Journal Article] Hyperthermia generated by magnetic nanoparticles for effective treatment of disseminated peritoneal cancer in an orthotopic nude-mouse model.2021
- Author(s)
  Matsumi Y, Kagawa T, Yano S, Tazawa H, Shigeyasu K, Takeda S, Ohara T, Aono H, Hoffman RM, Fujiwara T, Kishimoto H.
- Journal Title
  
  Cell Cycle
  
  Volume: 20(12) Issue: 12 Pages: 1122-1133
- DOI
  10.1080/15384101.2021.1919441
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07730, KAKENHI-PROJECT-19H03731
[Journal Article] Targeting neutrophil extracellular traps with thrombomodulin prevents pancreatic cancer metastasis2021
- Author(s)
  Kajioka Hiroki、Kagawa Shunsuke、Ito Atene、Yoshimoto Masashi、Sakamoto Shuichi、Kikuchi Satoru、Kuroda Shinji、Yoshida Ryuichi、Umeda Yuzo、Noma Kazuhiro、Tazawa Hiroshi、Fujiwara Toshiyoshi
- Journal Title
  
  Cancer Letters
  
  Volume: 497 Pages: 1-13
- DOI
  10.1016/j.canlet.2020.10.015
- NAID
  120007188794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09217, KAKENHI-PROJECT-18K08679, KAKENHI-PROJECT-19H03731
[Journal Article] Oncolytic virotherapy reverses chemoresistance in osteosarcoma by suppressing MDR1 expression2021
- Author(s)
  Sugiu Kazuhisa、Tazawa Hiroshi、Hasei Joe、Yamakawa Yasuaki、Omori Toshinori、Komatsubara Tadashi、Mochizuki Yusuke、Kondo Hiroya、Osaki Shuhei、Fujiwara Tomohiro、Yoshida Aki、Kunisada Toshiyuki、Ueda Koji、Urata Yasuo、Kagawa Shunsuke、Ozaki Toshifumi、Fujiwara Toshiyoshi
- Journal Title
  
  Cancer Chemotherapy and Pharmacology
  
  Volume: 88 Issue: 3 Pages: 513-524
- DOI
  10.1007/s00280-021-04310-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03731
[Journal Article] Local oncolytic adenovirotherapy produces an abscopal effect via tumor-derived extracellular vesicles2021
- Author(s)
  Yoshihiko Kakiuchi, Shinji Kuroda, Nobuhiko Kanaya, Kento Kumon, Tomoko Tsumura, Masashi Hashimoto, Chiaki Yagi, Ryoma Sugimoto, Yuki Hamada, Satoru Kikuchi, Masahiko Nishizaki, Shunsuke Kagawa, Hiroshi Tazawa, Yasuo Urata, Toshiyoshi Fujiwara
- Journal Title
  
  Molecular Therapy
  
  Volume: 29 Issue: 10 Pages: 2925-2930
- DOI
  10.1016/j.ymthe.2021.05.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17617, KAKENHI-PROJECT-19H03731
[Journal Article] Immuno-hyperthermia effected by antibody-conjugated nanoparticles selectively targets and eradicates individual cancer cells.2021
- Author(s)
  Kagawa T, Matsumi Y, Aono H, Ohara T, Tazawa H, Shigeyasu K, Yano S, Takeda S, Komatsu Y, Hoffman RM, Fujiwara T, Kishimoto H.
- Journal Title
  
  Cell Cycle
  
  Volume: 20(13) Issue: 13 Pages: 1221-1230
- DOI
  10.1080/15384101.2021.1915604
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07730, KAKENHI-PROJECT-19H03731, KAKENHI-PROJECT-21K16474
[Journal Article] Boosting Replication and Penetration of Oncolytic Adenovirus by Paclitaxel Eradicate Peritoneal Metastasis of Gastric Cancer.2020
- Author(s)
  Ishikawa W, Kikuchi S, Ogawa T, Tabuchi M, Tazawa H, Kuroda S, Noma K, Nishizaki M, Kagawa S, Urata Y, Fujiwara T.
- Journal Title
  
  Molecular Therapy-Oncolytics
  
  Volume: 18 Pages: 262-271
- DOI
  10.1016/j.omto.2020.06.021
- NAID
  120006892937
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03731
[Journal Article] Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer.2020
- Author(s)
  Koujima T., Tazawa H., Ieda T., Araki H., Fushimi T., Shoji R., Kuroda S., Kikuchi S., Yoshida R., Umeda Y., Teraishi F., Urata Y., Mizuguchi H., Fujiwara T.
- Journal Title
  
  Mol. Ther. Oncolysis.
  
  Volume: 17 Pages: 107-117
- DOI
  10.1016/j.omto.2020.03.016
- NAID
  120006869596
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H00863, KAKENHI-PROJECT-19K09217, KAKENHI-PROJECT-19H03731, KAKENHI-PROJECT-20H00664
[Journal Article] Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody.2020
- Author(s)
  Kanaya N., Kuroda S., Kakiuchi Y., Kumon K., Tsumura T., Hashimoto M., Morihiro T., Kubota T., Aoyama K., Kikuchi S., Nishizaki M., Kagawa S., Tazawa H., Mizuguchi H., Urata Y., Fujiwara T.
- Journal Title
  
  Mol. Ther.
  
  Volume: 28 Issue: 3 Pages: 794-804
- DOI
  10.1016/j.ymthe.2020.01.003
- NAID
  120006952300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H00863, KAKENHI-PROJECT-19H03731, KAKENHI-PROJECT-20H00664
[Journal Article] Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression.2020
- Author(s)
  Tanimoto T, Tazawa H, Ieda T, Nouso H, Tani M, Oyama T, Urata Y, Kagawa S, Noda T, Fujiwara T.
- Journal Title
  
  Molecular Therapy-Oncolytics
  
  Volume: 18 Pages: 14-23
- DOI
  10.1016/j.omto.2020.05.015
- NAID
  120006892941
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03731
[Journal Article] PD-L1 expression combined with microsatellite instability/CD8+ tumor infiltrating lymphocytes as a useful prognostic biomarker in gastric cancer.2019
- Author(s)
  Morihiro T, Kuroda S, Kanaya N, Kakiuchi Y, Kubota T, Aoyama K, Tanaka T, Kikuchi S, Nagasaka T, Nishizaki M, Kagawa S, Tazawa H, Fujiwara T.
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 4633-4633
- DOI
  10.1038/s41598-019-41177-2
- NAID
  120006777516
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03731
[Journal Article] Cancer-associated fibroblasts (CAFs) promote the lymph node metastasis of esophageal squamous cell carcinoma.2019
- Author(s)
  Kashima H, Noma K, Ohara T, Kato T, Katsura Y, Komoto S, Sato H, Katsube R, Ninomiya T, Tazawa H, Shirakawa Y, Fujiwara T.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 144 Issue: 4 Pages: 828-840
- DOI
  10.1002/ijc.31953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05416, KAKENHI-PROJECT-16K10500
[Journal Article] Activation of AZIN1 RNA editing is a novel mechanism that promotes invasive potential of cancer-associated fibroblasts in colorectal cancer2019
- Author(s)
  Takeda S, Shigeyasu K, Okugawa Y, Yoshida K, Mori Y, Yano S, Noma K, Umeda Y, Kondo Y, Kishimoto H, Teraishi F, Nagasaka T, Tazawa H, Kagawa S, Fujiwara T, Goel A.
- Journal Title
  
  Cancer Lett
  
  Volume: 444 Pages: 127-135
- DOI
  10.1016/j.canlet.2018.12.009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10634, KAKENHI-PROJECT-18K08566, KAKENHI-PROJECT-18K08591, KAKENHI-PROJECT-19K09143, KAKENHI-PROJECT-19K09217, KAKENHI-PROJECT-19H03731, KAKENHI-PROJECT-17K16557
[Journal Article] Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment?colorectal cancer network2019
- Author(s)
  Ieda Takeshi、Tazawa Hiroshi、Okabayashi Hiroki、Yano Shuya、Shigeyasu Kunitoshi、Kuroda Shinji、Ohara Toshiaki、Noma Kazuhiro、Kishimoto Hiroyuki、Nishizaki Masahiko、Kagawa Shunsuke、Shirakawa Yasuhiro、Saitou Takashi、Imamura Takeshi、Fujiwara Toshiyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 16378-16378
- DOI
  10.1038/s41598-019-52816-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12218, KAKENHI-PROJECT-19H03731, KAKENHI-PROJECT-17K10589, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-18K08679
[Journal Article] Cancer-Associated Fibroblasts Affect Intratumoral CD8+ and FoxP3+ T Cells Via IL6 in the Tumor Microenvironment.2018
- Author(s)
  Kato T, Noma K, Ohara T, Kashima H, Katsura Y, Sato H, Komoto S, Katsube R, Ninomiya T, Tazawa H, Shirakawa Y, Fujiwara T
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 24 Issue: 19 Pages: 4820-4833
- DOI
  10.1158/1078-0432.ccr-18-0205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05416
[Journal Article] 膵癌に対するウイルス療法の実用化に向けて2018
- Author(s)
  國府島　健、田澤　大、杭瀬　崇、吉田龍一、楳田祐三、藤原俊義
- Journal Title
  
  消化器外科
  
  Volume: 41 Pages: 931-938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10596
[Journal Article] Integrated fluorescent cytology with nano-biologics in peritoneally disseminated gastric cancer.2018
- Author(s)
  Watanabe M, Kagawa S, Kuwada K, Hashimoto Y, Shigeyasu K, Ishida M, Sakamoto S, Ito A, Kikuchi S, Kuroda S, Kishimoto H, Tomida S, Yoshida R, Tazawa H, Urata Y, Fujiwara T
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 10 Pages: 3263-3271
- DOI
  10.1111/cas.13760
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05416, KAKENHI-PROJECT-18K08679
[Journal Article] Impact of Autophagy in Oncolytic Adenoviral Therapy for Cancer2017
- Author(s)
  Tazawa Hiroshi、Kuroda Shinji、Hasei Joe、Kagawa Shunsuke、Fujiwara Toshiyoshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 18 Issue: 7 Pages: 1479-1479
- DOI
  10.3390/ijms18071479
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10596
[Journal Article] Role of zoledronic acid in oncolytic virotherapy: Promotion of antitumor effect and prevention of bone destruction2017
- Author(s)
  Yamakawa Yasuaki、Tazawa Hiroshi、Hasei Joe、Osaki Shuhei、Omori Toshinori、Sugiu Kazuhisa、Komatsubara Tadashi、Uotani Kouji、Fujiwara Tomohiro、Yoshida Aki、Kunisada Toshiyuki、Urata Yasuo、Kagawa Shunsuke、Ozaki Toshifumi、Fujiwara Toshiyoshi
- Journal Title
  
  Cancer Science
  
  Volume: 108 Issue: 9 Pages: 1870-1880
- DOI
  10.1111/cas.13316
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10862, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-16H05416, KAKENHI-PROJECT-15K10446
[Journal Article] Management of early gastric cancer that meet the indication for radical lymph node dissection following endoscopic resection: a retrospective cohort analysis.2017
- Author(s)
  Aoyama, K., Kuroda, S., Morihiro, T., Kanaya, N., Kubota, T., Kakiuchi, Y., Kikuchi, S., Nishizaki, M., Kagawa, S., Tazawa, H., Fujiwara, T
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 14177-14177
- DOI
  10.1038/s41598-017-14717-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05416
[Journal Article] OBP-401-GFP telomerase-dependent adenovirus illuminates and kills high-metastatic more effectively than low-metastatic triple-negative breast cancer in vitro.2017
- Author(s)
  Yano, S., Takehara, K., Kishimoto, H., Tazawa, H., Urata, Y., Kagawa, S., Bouvet, M., Fujiwara, T., Hoffman, R.M
- Journal Title
  
  Cancer Gene Therapy
  
  Volume: 20 Issue: 16 Pages: 45-47
- DOI
  10.1080/15384101.2016.1249548
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05416
[Journal Article] Ablation of MCL1 expression by virally induced microRNA-29 reverses chemoresistance in human osteosarcomas.2016
- Author(s)
  Osaki S, Tazawa H, Hasei J, Yamakawa Y, Omori T, Sugiu K, Komatsubara T, Fujiwara T, Sasaki T, Kunisada T,
- Journal Title
  
  Sci Rep.
  
  Volume: 30(6) Issue: 1 Pages: 28953-28953
- DOI
  10.1038/srep28953
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-16H05416, KAKENHI-PROJECT-16K10862
[Journal Article] Tumor-specific delivery of biologics by a novel T-cell line HOZOT.2016
- Author(s)
  Onishi T, Tazawa H, Hashimoto Y, Takeuchi M, Otani T, Nakamura S, Sakurai F, Mizuguchi H, Kishimoto H, Umeda Y, Shirakawa Y, Urata Y, Kagawa S, Fujiwara T.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 38060-38060
- DOI
  10.1038/srep38060
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05416, KAKENHI-PROJECT-16K10573, KAKENHI-PROJECT-15K15193
[Journal Article] Trastuzumab-Based Photoimmunotherapy Integrated with Viral HER2 Transduction Inhibits Peritoneally Disseminated HER2-Negative Cancer2016
- Author(s)
  Ishida M, Kagawa S, Shimoyama K, Takehara K, Noma K, Tanabe S, Shirakawa Y, Tazawa H, Kobayashi H, Fujiwara T
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 15 Issue: 3 Pages: 402-411
- DOI
  10.1158/1535-7163.mct-15-0644
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462021, KAKENHI-PROJECT-25293283, KAKENHI-PROJECT-16H05416
[Journal Article] Targeted photodynamic virotherapy armed with a genetically encoded photosensitizer.2016
- Author(s)
  Takehara K, Kagawa S, Fujiwara T, et al.
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 15 Issue: 1 Pages: 199-208
- DOI
  10.1158/1535-7163.mct-15-0344
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293283, KAKENHI-PROJECT-16H05416, KAKENHI-PROJECT-16K21185
[Journal Article] Viral transduction of the HER2-extracellular domain expands trastuzumab-based photoimmunotherapy for HER2-negative breast cancer cells2015
- Author(s)
  Shimoyama K, Kagawa S, Ishida M, Watanabe S, Noma K, Takehara K, Tazawa H, Hashimoto Y, Tanabe S, Matsuoka J, Kobayashi H, Fujiwara T
- Journal Title
  
  Breast Cancer Reseach and Treatment
  
  Volume: 149 Issue: 3 Pages: 597-605
- DOI
  10.1007/s10549-015-3265-y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25462021, KAKENHI-PROJECT-25462057
[Journal Article] Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability.2015
- Author(s)
  Toda K, Nagasaka T, Umeda Y, Tanaka T, Kawai T, Fuji T, Taniguchi F, Yasui K, Kubota N, Takehara Y, Tazawa H, Kagawa S, Sun DS, Nishida N, Goel A, Fujiwara T.
- Journal Title
  
  Clin Epigenetics
  
  Volume: 7 Issue: 1 Pages: 73-73
- DOI
  10.1186/s13148-015-0096-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09028, KAKENHI-PROJECT-15H03034, KAKENHI-PROJECT-25462057, KAKENHI-PROJECT-25860409
[Journal Article] Biological ablation of sentinel lymph node metastasis in submucosally invaded early gastrointestinal cancer.2015
- Author(s)
  Kikuchi S, et al.
- Journal Title
  
  Molecular Therapy
  
  Volume: 23 Issue: 3 Pages: 501-509
- DOI
  10.1038/mt.2014.244
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293283, KAKENHI-PROJECT-25462021, KAKENHI-PROJECT-25670580, KAKENHI-PROJECT-26461978, KAKENHI-PROJECT-25462057
[Journal Article] Color-coding cancer and stromal cells with genetic reporters in a patient-derived orthotopic xenograft (PDOX) model of pancreatic cancer enhances fluorescence-guided surgery.2015
- Author(s)
  Yano S, Hiroshima Y, Maawy A, Kishimoto H, Suetsugu A, Miwa S, Toneri M, Yamamoto M, Katz MH, Fleming JB, Urata Y, Tazawa H, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM.
- Journal Title
  
  Cancer Gene Ther
  
  Volume: 22 Issue: 7 Pages: 344-50
- DOI
  10.1038/cgt.2015.26
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460997, KAKENHI-PROJECT-25462057, KAKENHI-PROJECT-25293283
[Journal Article] Therapeutic Potential of Targeting Cancer-Associated Fibroblasts in Esophageal Cancer2015
- Author(s)
  Noma K, Kashima H, Ninomiya T, Katsube R, Watanabe S, Ohara T, Tazawa H, Kagawa S, Shirakawa Y, Fujiwara T.
- Journal Title
  
  癌と化学療法
  
  Volume: 42 Pages: 1228-30
- Data Source
  KAKENHI-PROJECT-26861077
[Journal Article] Targeting tumors with a killer-reporter adenovirus for curative fluorescence-guided surgery of soft-tissue sarcoma2015
- Author(s)
  Yano S, Miwa S, Kishimoto H, Uehara F, Tazawa H, Toneri M, Hiroshima Y, Yamamoto M, Urata Y, Kagawa S, Bouvet M, Fujiwara T
- Journal Title
  
  Oncotarget
  
  Volume: 6 Pages: 13133-13148
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462057
[Journal Article] Experimental curative fluorescence-guided surgery of highly-invasive glioblastoma multiforme selectively labeled with a killer-reporter adenovirus2015
- Author(s)
  Yano S, Miwa S, Kishimoto H, Toneri M, Hiroshima Y, Yamamoto M, Bouvet M, Urata Y, Tazawa H, Kagawa S, Fujiwara T, Hoffman RM
- Journal Title
  
  Mol Ther
  
  Volume: 23 Issue: 7 Pages: 1182-1188
- DOI
  10.1038/mt.2015.63
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462057, KAKENHI-PROJECT-25293283
[Journal Article] Biological ablation of sentinel lymph node metastasis in submucosally invaded early gastrointestinal cancer.2015
- Author(s)
  Kikuchi S, Kishimoto H, Tazawa H, Hashimoto Y, Kuroda S, Nishizaki M, Nagasaka T, Shirakawa Y, Kagawa S, Urata Y, Hoffman RM, Fujiwara T.
- Journal Title
  
  Mol Ther.
  
  Volume: 23(3) Issue: 4 Pages: 501-509
- DOI
  10.1136/gutjnl-2014-306957
- NAID
  120005537574
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790700, KAKENHI-PROJECT-25293283, KAKENHI-PROJECT-25670580, KAKENHI-PROJECT-26461978, KAKENHI-PROJECT-15H03034, KAKENHI-PROJECT-25462057
[Journal Article] Cancer cells mimic in vivo spatial-temporal cell-cycle phase distribution and chemosensitivity in 3-dimensional gelfoam histoculture but not 2-dimensional culture as visualized with real-time FUCCI imaging2015
- Author(s)
  Yano S, Miwa S, Mii S, Hiroshima Y, Uehara F, Kishimoto H, Tazawa H, Zhao M, Bouvet M, Fujiwara T, Hoffman RM
- Journal Title
  
  Cell Cycle
  
  Volume: 14 Issue: 6 Pages: 808-819
- DOI
  10.1080/15384101.2014.1000685
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462057
[Journal Article] Invading cancer cells are predominantly in G0/G1 resulting in chemoresistance demonstrated by real-time FUCCI imaging2014
- Author(s)
  Yano S, Miwa S, Mii S, Hiroshima Y, Uehara F, Yamamoto M, Kishimoto H, Tazawa H, Bouvet M, Fujiwara T, Hoffman RM
- Journal Title
  
  Cell Cycle
  
  Volume: 13 Issue: 6 Pages: 953-960
- DOI
  10.4161/cc.27818
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462057
[Journal Article] Molecular diagnosis and therapy for occult peritoneal metastasis in gastric cancer patients2014
- Author(s)
  Kagawa S, Shigeyasu K, Ishida M, Watanabe M, Tazawa H, Nagasaka T, Shirakawa Y, Fujiwara T
- Journal Title
  
  World Journal of Gastroenterology
  
  Volume: 20 Issue: 47 Pages: 17796-17803
- DOI
  10.3748/wjg.v20.i47.17796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462021
[Journal Article] Establishment of a non-invasive semi-quantitative bioluminescent imaging method for monitoring of an orthotopic esophageal cancer mouse model.2014
- Author(s)
  Kuroda S, et al.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 12 Pages: e114562-e114562
- DOI
  10.1371/journal.pone.0114562
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293283, KAKENHI-PROJECT-25670580, KAKENHI-PROJECT-26461978
[Journal Article] Dual programmed cell death pathways induced by p53 transactivation overcome resistance to oncolytic adenovirus in human osteosarcoma cells2013
- Author(s)
  Hasei J, Sasaki T, Tazawa H, Osaki S, Yamakawa Y, Kunisada T, Yoshida A, Hashimoto Y, Onishi T, Uno F, Kagawa S, Urata Y, Ozaki T, Fujiwara T
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 12: 314-325
- NAID
  120005324798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791310
[Journal Article] Advances in adenovirus-mediated p53 cancer gene therapy.2013
- Author(s)
  Tazawa H, Kagawa S, Fujiwara T
- Journal Title
  
  Expert opinion on biological therapy.
  
  Volume: 13 Issue: 11 Pages: 1569-1583
- DOI
  10.1517/14712598.2013.845662
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591932, KAKENHI-PROJECT-25462021, KAKENHI-PROJECT-25462057
[Journal Article] A simple detection system for adenovirus receptor expression using a telomerase-specific replication-competent adenovirus2013
- Author(s)
  Sasaki T, Tazawa H, Hasei J, Osaki S, Kunisada T, Yoshida A, Hashimoto Y, Yano S, Yoshida R, Kagawa S, Uno F, Urata Y, Ozaki T, Fujiwara T
- Journal Title
  
  Gene Ther
  
  Volume: 20: 112-118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791310
[Journal Article] A genetically　engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells into S/G2/M-phases.2013
- Author(s)
  Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto　H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T
- Journal Title
  
  Clin Cancer Res
  
  Volume: 19 Issue: 23 Pages: 6495-6505
- DOI
  10.1158/1078-0432.ccr-13-0742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390323, KAKENHI-PROJECT-23591932, KAKENHI-PROJECT-25293283, KAKENHI-PROJECT-25462021, KAKENHI-PROJECT-25462057, KAKENHI-PROJECT-25670580
[Journal Article] Oncolytic adenovirus-induced autophagy: tumor-suppressive effect and molecular basis2013
- Author(s)
  Tazawa H, Kagawa S, Fujiwara T
- Journal Title
  
  Acta Medica Okayama
  
  Volume: 67 Pages: 333-342
- NAID
  120005353344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462057
[Journal Article] Chronic inflammation-derived nitric oxide causes conversion of human colonic adenoma cells into adenocarcinoma cells2013
- Author(s)
  Tazawa H, Kawaguchi T, Kobayashi T, Kuramitsu Y, Wada S, Satomi Y, Nishino H, Kobayashi M, Kanda Y, Osaki M, Kitagawa T, Hosokawa M and Okada F
- Journal Title
  
  Exp Cell Res
  
  Volume: 319 Issue: 18 Pages: 2835-2844
- DOI
  10.1016/j.yexcr.2013.08.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590461, KAKENHI-PROJECT-24501352, KAKENHI-PROJECT-25462057
[Journal Article] A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells in S/G2/M phases.2013
- Author(s)
  Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 19 Pages: 6495-6505
- NAID
  120005468273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591932
[Journal Article] Mechanism of resistance to trastuzumab and molecular sensitization via ADCC activation by exogenous expression of HER2-extracellular domain in human cancer cells2012
- Author(s)
  Yoshida R, Tazawa H, Hashimoto Y, Yano S, Onishi T, Sasaki T, Shirakawa Y, Kishimoto H, Uno F, Nishizaki M, Kagawa S, Fujiwara T
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 61: 1905-1916
- NAID
  120005232490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791310
[Journal Article] Genetically engineered oncolytic adenovirus induces autophagic cell death through an E2F1-microRNA-7-epidermal growth factor receptor axis2012
- Author(s)
  Tazawa, H.
- Journal Title
  
  International Journal of Cancer
  
  Volume: (Epub ahead of print) Issue: 12 Pages: 2939-2950
- DOI
  10.1002/ijc.27589
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03792, KAKENHI-PROJECT-22390256, KAKENHI-PROJECT-22791310, KAKENHI-PROJECT-24890132
[Journal Article] A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression.2012
- Author(s)
  Yamasaki Y, Tazawa H, Hashimoto Y, Kojima T, Kuroda S, Yano S, Yoshida R, Uno F, Mizuguchi H, Ohtsuru A, Urata Y, Kagawa S, Fujiwara T.
- Journal Title
  
  European journal of cancer
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591932
[Journal Article] Mechanism of resistance to trastuzumab and molecular sensitization via ADCC activation by exogenous expression of HER2-extracellular domain in human cancer cells.2012
- Author(s)
  Yoshida, R.
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 61 Issue: 11 Pages: 1905-1916
- DOI
  10.1007/s00262-012-1249-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390256, KAKENHI-PROJECT-22791310, KAKENHI-PROJECT-23591932, KAKENHI-PROJECT-24890132
[Journal Article] A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression2012
- Author(s)
  Yamasaki Y, Tazawa H, Hashimoto Y, Kojima T, Kuroda S, Yano S, Yoshida R, Uno F, Mizuguchi H, Ohtsuru A, Urata Y, Kagawa S, Fujiwara T
- Journal Title
  
  Eur J Cancer
  
  Volume: 48: 2282-2291
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791310
[Journal Article] Genetically engineered oncolytic adenovirus induces autophagic cell death through an E2F1-microRNA-7-epidermal growth factor receptor axis2012
- Author(s)
  Tazawa H, Yano S, Yoshida R, Yamasaki Y, Sasaki T, Hashimoto Y, Kuroda S, Ouchi M, Onishi T, Uno F, Kagawa S, Urata Y, Fujiwara T
- Journal Title
  
  Int J Cancer
  
  Volume: 131: 2939-2950
- NAID
  130004505785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791310
[Journal Article] The hTERT promoter enhances the antitumor activity of an oncolytic adenovirus under a hypoxic microenvironment2012
- Author(s)
  Hashimoto Y, Tazawa H, Teraishi F, Kojima T, Watanabe Y, Uno F, Yano S, Urata Y, Kagawa S, Fujiwara T
- Journal Title
  
  PLoS One
  
  Volume: 7: e39292
- NAID
  120005232484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791310
[Journal Article] A simple detection system for adenovirus receptor expression using a telomerase-specific replication-competent adenovirus2012
- Author(s)
  Sasaki, T.
- Journal Title
  
  Gene Therapy
  
  Volume: (Epub ahead of print) Issue: 1 Pages: 112-118
- DOI
  10.1038/gt.2011.213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J03792, KAKENHI-PROJECT-22390256, KAKENHI-PROJECT-22791310, KAKENHI-PROJECT-23591932, KAKENHI-PROJECT-24890132, KAKENHI-PROJECT-25293283, KAKENHI-PROJECT-25670580
[Journal Article] Synergistic Interaction of Telomerase-Specific Oncolytic Virotherapy and Chemotherapeutic Agents for Human Cancer.2011
- Author(s)
  Fujiwara T, Kagawa S, Tazawa H.
- Journal Title
  
  Current pharmaceutical biotechnology
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591932
[Journal Article] Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas2011
- Author(s)
  Sasaki T, Tazawa H, Hasei J, Kunisada T, Yoshida A, Hashimoto Y, Yano S, Yoshida R, Uno F, Kagawa S, Morimoto Y, Urata Y, Ozaki T, Fujiwara T
- Journal Title
  
  Clin Cancer Res
  
  Volume: 17: 1828-1838
- NAID
  40019397235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791310
[Journal Article] MicroRNAs as potential target gene in cancer gene therapy of gastrointestinal tumors.2011
- Author(s)
  Hiroshi Tazawa
- Journal Title
  
  Expert Opinion on Biological Therapy
  
  Volume: 11 Pages: 145-155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791310
[Journal Article] Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas2011
- Author(s)
  Sasaki T, et al
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 17 Issue: 7 Pages: 1828-1838
- DOI
  10.1158/1078-0432.ccr-10-2066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390256, KAKENHI-PROJECT-22791310, KAKENHI-PROJECT-23591932
[Journal Article] Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery2010
- Author(s)
  Kuroda S, Fujiwara T, Shirakawa Y, Yamasaki Y, Yano S, Uno F, Tazawa H, Hashimoto Y, Watanabe Y, Noma K, Urata Y, Kagawa S, Fujiwara T
- Journal Title
  
  Cancer Res
  
  Volume: 70: 9339-9348
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791310
[Journal Article] In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy2010
- Author(s)
  Kojima T, Watanabe Y, Hashimoto Y, Kuroda S, Yamasaki Y, Yano S, Ouchi M, Tazawa H, Uno F, Kagawa S, Kyo S, Mizuguchi H, Urata Y, Tanaka N, Fujiwara T
- Journal Title
  
  Ann Surg
  
  Volume: 251: 1079-1086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] Metabolic reprogramming by anti-mitochondrial agent promotes the antitumor efficacy of telomerase-specific oncolytic adenoviruses against virotherapy-resistant pancreatic cancer2022
- Author(s)
  Shoji R, Tazawa H, Nagai Y, Yamada M, Kajiwara Y, Kikuchi S, Kuroda S, Urata Y, Kagawa S, Fujiwara T
- Organizer
  14th International Oncolytic Virotherapy Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07219
[Presentation] 難治性膵臓癌に対する代謝調節剤を併用したp53武装化アデノウイルス療法の治療戦略2022
- Author(s)
  庄司良平、田澤大、菊地覚次、黒田新士、吉田龍一、浦田泰生、香川俊輔、藤原俊義
- Organizer
  第43回癌免疫外科研究会
- Data Source
  KAKENHI-PROJECT-21K07219
[Presentation] Metabolic reprogramming by anti-mitochondrial agent promotes sensitivity to oncolytic adenoviruses in non-glycolytic pancreatic cancer2022
- Author(s)
  Shoji R, Tazawa H, Kikuchi S, Kuroda S, Yoshida R, Urata Y, Kagawa S, Fujiwara T
- Organizer
  第28回日本遺伝子細胞治療学会
- Data Source
  KAKENHI-PROJECT-21K07219
[Presentation] 難治性膵臓癌に対するミトコンドリア阻害剤と腫瘍融解ウイルスの併用療法2022
- Author(s)
  庄司良平、田澤大、菊地覚次、黒田新士、吉田龍一、浦田泰生、香川俊輔、藤原俊義
- Organizer
  第60回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07219
[Presentation] 膵臓癌の代謝サブタイプが腫瘍融解アデノウイルスに対する感受性を運命づける2021
- Author(s)
  庄司良平、田澤大、梶原義典、李云成、山田元彦、井上弘章、永井康雄、菊地覚次、黒田新士、吉田龍一、浦田泰生、香川俊輔、藤原俊義
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07219
[Presentation] 膵臓癌の代謝サブタイプに基づくp53誘導性腫瘍融解ウイルス療法の治療戦略2021
- Author(s)
  庄司良平、田澤大、吉田龍一、浦田泰生、香川俊輔、藤原俊義
- Organizer
  第34回日本バイオセラピィ学会
- Data Source
  KAKENHI-PROJECT-21K07219
[Presentation] 解熱剤のアスピリンはEMT阻害によって大腸がん腹膜播種を抑制する2019
- Author(s)
  岡林弘樹、田澤大、家田偉史、矢野修也、菊地覚次、黒田新士、西崎正彦、香川俊輔、今村健志、藤原俊義
- Organizer
  第32回日本バイオセラピィ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-17K10589
[Presentation] 解熱剤のアスピリンはEMT阻害作用を介して大腸がんの腹膜播種を抑制する2019
- Author(s)
  岡林弘樹、田澤大、家田偉史、矢野修也、菊地覚次、黒田新士、西崎正彦、香川俊輔、今村健志、藤原俊義
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K10589
[Presentation] Oncolytic adenovirus-mediated p53 overexpression induces profound immunogenic cell death in human pancreatic ductal adenocarcinoma cells.2018
- Author(s)
  Araki H, Tazawa H, Ieda T, Fushimi T, Kuroda S, Yoshida R, Kishimoto H, Nishizaki M, Urata Y, Kagawa S, Fujiwara T.
- Organizer
  第24回日本遺伝子細胞治療学会
- Data Source
  KAKENHI-PROJECT-16K10596
[Presentation] Overexpression of tumor suppressor p53 gene by oncolytic adenovirus boosts immune responses in human pancreatic ductal adenocarcinoma cells.2018
- Author(s)
  Araki H, Tazawa H, Ieda T, Fushimi T, Kuroda S, Yoshida R, Kishimoto H, Nishizaki M, Urata Y, Kagawa S, Fujiwara T.
- Organizer
  109th Annual Meeting of the American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10596
[Presentation] 炎症性微小環境―大腸がんクロストークにおけるEMTイメージング2018
- Author(s)
  田澤　大、家田偉史、矢野修也、重安邦俊、黒田新士、大原利章、野間和広、岸本浩行、西崎正彦、香川俊輔、白川靖博、齋藤　卓、今村健志、藤原俊義
- Organizer
  第77回日本癌学会学術総会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10589
[Presentation] Visualization of epithelial-mesenchymal transition in inflammatory microenvironment-colorectal cancer network in vitro and in vivo.2018
- Author(s)
  Tazawa H, Ieda T, Yano S, Kikuchi S, Kuroda S, Ohara T, Noma K, Kishimoto H, Nishizaki M, Kagawa S, Saitou T, Imamura T, Fujiwara T.
- Organizer
  109th Annual Meeting of the American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10589
[Presentation] 膵癌に対するp53誘導性腫瘍融解ウイルスによる免疫原性細胞死の誘導効果2018
- Author(s)
  荒木宏之、田澤　大、金谷信彦、菊地覚次、黒田新士、吉田龍一、岸本浩行、西崎正彦、浦田泰生、香川俊輔、藤原俊義
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10596
[Presentation] Fluorescence-guided spatiotemporal dynamics of epithelial-mesenchymal transition under inflammatory microenvironment during colorectal cancer progression.2017
- Author(s)
  Ieda T, Tazawa H, Kikuchi S, Kuroda S, Ohara T, Noma K, Kishimoto H, Nagasaka T, Nishizaki M, Kagawa S, Fujiwara T.
- Organizer
  108th Annual Meeting of the American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10589
[Presentation] EMT-がん微小環境ネットワークの蛍光生細胞イメージングシステム2017
- Author(s)
  家田偉史、田澤　大、菊地覚次、黒田新士、大原利章、野間和広、岸本浩行、永坂岳司、西崎正彦、香川俊輔、今村健志、藤原俊義
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K10589
[Presentation] Tumor associated macrophages promote malignant phenotypes of disseminated human gastric cancer cells in intraperitoneal cancer immune microenvironment2017
- Author(s)
  Shuichi Sakamoto, Shunsuke Kagawa, Kazuya Kuwada, Atene Ito, Tetsuya Kagawa, Satoru Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Hiroshi Tazawa, Toshiyoshi Fujiwara
- Organizer
  American Association for Cancer Research, Annual Meeting 2017
- Place of Presentation
  ワシントンDC, 米国
- Year and Date
  2017-04-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15193
[Presentation] Intraperitoneal macrophages in patients with gastric cancer are polarized to promote malignant phenotypes of disseminated cancer cells.2016
- Author(s)
  渡辺めぐみ, 香川俊輔, 桒田和也, 坂本修一, 菊地覚次, 黒田新士, 岸本浩行, 西崎正彦, 田澤大, 藤原俊義
- Organizer
  第71回　日本消化器外科学会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-15K15193
[Presentation] p53活性化能を有するテロメラーゼ標的型ウイルス療法による腹腔内胃癌微小環境の浄化作用2016
- Author(s)
  田澤　大、堀　直人、國府島　健、谷本光隆、家田偉史、渡邉めぐみ、黒田新士、西崎正彦、浦田泰生、香川俊輔、藤原俊義
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26461978
[Presentation] Virally enhanced p53 reactivation impairs KRAS-driven pancreatic cancer invasion2016
- Author(s)
  Koujima T, Tazawa H, Ieda T, Kuwada K, Tanimoto T, Kuroda S, Kishimoto H, Nishizaki M, Urata Y, Kagawa S, Fujiwara T
- Organizer
  107th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10596
[Presentation] 蛍光ウイルスによる腹腔内の腫瘍関連マクロファージと膵癌細胞の関連性の解析2016
- Author(s)
  桑田和也, 香川俊輔, 坂本修一, 渡邉めぐみ, 香川哲也, 菊地覚次, 黒田新士, 吉田龍一, 浦田泰生, 田澤大, 藤原俊義
- Organizer
  第75回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K15193
[Presentation] 炎症性微小環境によって誘導されるEMTの蛍光生細胞イメージングシステム2016
- Author(s)
  家田偉史、田澤　大、菊地覚次、黒田新士、大原利章、野間和広、岸本浩行、永坂岳司、西崎正彦、香川俊輔、今村健志、藤原俊義
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26461978
[Presentation] 標的陰性癌に対するPhotoimmunotherapy．抗原修飾による抗原陽転化と不均一性の克服．2016
- Author(s)
  香川俊輔，石田道拡，下山京子，竹原清人，野間和広，田辺俊介，渡邉めぐみ，田澤大，小林久隆，藤原俊義
- Organizer
  第71回日本消化器外科学会総会
- Place of Presentation
  徳島県徳島市
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-25462021
[Presentation] Inhibition of peritoneal dissemination of scirrhous gastric cancer by oncolytic adenovirus-mediated activation of tumor suppressor p53 and suppression of oncogenic receptor tyrosine kinase2016
- Author(s)
  Tazawa H, Hori N, Koujima T, Kuwada K, Tanimoto T, Kuroda S, Nishizaki M, Urata Y, Kagawa S, Fujiwara T
- Organizer
  第22回日本遺伝子細胞治療学会
- Place of Presentation
  東京
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26461978
[Presentation] Impairment of KRAS-driven pancreatic cancer growth and invasion by tumor-specific oncolytic adenoviruses2016
- Author(s)
  Koujima T, Tazawa H、Kuwada K、Tanimoto T、Kuroda S、Kishimoto H、Nishizaki M、Urata Y、Kagawa S、Fujiwara T
- Organizer
  第22回日本遺伝子治療学会
- Place of Presentation
  東京
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-16K10596
[Presentation] Clinical implications of fluorescence-emitting virus guided peritoneal cytology in gastrointestinal cancer.2016
- Author(s)
  Kagawa S, Watanabe M, Kuwata K, Sakamoto S, Shigeyasu K, Tazawa H, Kuroda S, Kikuchi S, Yoshida R, Nishizaki M, Kishimoto H, Nagasaka T, Fujiwara T.
- Organizer
  The 19th International Congress of Cytology: ICC2016
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-05-28
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15193
[Presentation] A novel imaging system for inflammation-induced epithelial-mesenchymal transition in colorectal cancers2016
- Author(s)
  Ieda T, Tazawa H, Kikuchi S, Kuroda S, Ohara T, Noma K, Kishimoto H, Nagasaka T, Nishizaki M, Kagawa S, Fujiwara T
- Organizer
  107th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461978
[Presentation] Virus-guided fluorescent imaging of pancreatic cancer cells in the peritoneal cavity for an insight into roles of tumor-associated macrophage2016
- Author(s)
  Kazuya Kuwada, Shunsuke Kagawa, Megumi Watanabe, Shuichi Sakamoto, Tetsuya Kagawa, Satoru Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Hiroshi Tazawa and Toshiyoshi Fujiwara.
- Organizer
  The 22nd Annual Meeting of Japan Society of Gene and Cell Therapy
- Place of Presentation
  虎ノ門ヒルズフォーラム（東京都港区）
- Year and Date
  2016-07-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15193
[Presentation] 分化型胃癌細胞による癌関連線維芽細胞の活性化機構2015
- Author(s)
  李　云成、田澤　大、西崎正彦、橋本悠里、堀　直人、勝部亮一、黒田新士、野間和広、香川俊輔、藤原俊義
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26461978
[Presentation] Preclinical evaluation of telomerase-specific p53 tumor suppressor gene overexpression in human scirrhous gastric cancer cells with different p53 status2015
- Author(s)
  Hori N, Tazawa H, Nishizaki M, Watanabe M, Tamura S, Koujima T, Kuroda S, Urata Y, Kagawa S, Fujiwara T
- Organizer
  第21回日本遺伝子治療学会
- Place of Presentation
  大阪
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26461978
[Presentation] Companion diagnostics-based telomerase-specific oncolytic virotherapy: preclinical evaluation in human colorectal cancer cell lines differentially affected in the RAS/RAF/MEK signaling pathway2015
- Author(s)
  Tamura S, Tazawa H, Hori N, Koujima T, Kikuchi S, Kuroda S, Kishimoto H, Nagasaka T, Nishizaki M, Urata Y, Kagawa S, Fujiwara T
- Organizer
  106th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462057
[Presentation] スキルス胃癌細胞に対する腫瘍特異的p53遺伝子治療の前臨床評価2015
- Author(s)
  堀　直人、田澤　大、西崎正彦、渡邉めぐみ、田村周太、國府島　健、黒田新士、浦田泰生、香川俊輔、藤原俊義
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-26461978
[Presentation] Preclinical evaluation of tumor-specific oncolytic virotherapy against human colorectal cancer cells with different KRAS/BRAF mutation and microsatellite stability2015
- Author(s)
  Tamura S, Tazawa H, Hori N, Koujima T, Kikuchi S, Kuroda S, Kishimoto H, Nagasaka T, Nishizaki M, Urata Y, Kagawa S, Fujiwara T
- Organizer
  第21回日本遺伝子治療学会
- Place of Presentation
  大阪
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-25462057
[Presentation] KRAS/BRAF変異を持つ大腸癌に対する新たな腫瘍融解ウイルス療法の開発2015
- Author(s)
  田村周太、田澤　大、堀　直人、國府島　健、菊地覚次、黒田新士、岸本浩行、永坂岳司、西崎正彦、浦田泰生、香川俊輔、藤原俊義
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25462057
[Presentation] Differentiated gastric cancer cells have a potential to induce cancer-associated fibroblasts2015
- Author(s)
  Li Y, Tazawa H, Nishizaki M, Hashimoto Y, Hori N, Katsube R, Kuroda S, Noma K, Kagawa S, Fujiwara T
- Organizer
  106th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461978
[Presentation] Preclinical study of telomerase-specific p53 tumor suppressor overexpression in human scirrhous gastric cancer cells with different p53 status2015
- Author(s)
  Hori N, Tazawa H, Nishizaki M, Kikuchi S, Yano S, Ishida M, Watanabe M, Urata Y, Kagawa S, Fujiwara T
- Organizer
  106th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461978
[Presentation] HER2抗原で修飾された癌細胞に対するTrastuzumabを用いた近赤外線光線免疫療法の効果2014
- Author(s)
  石田道拡, 香川俊輔, 下山京子, 竹原清人, 野間和広, 田澤　大, 黒田新士, 岸本浩行, 田邊俊介, 小林久隆, 藤原俊義
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25462021
[Presentation] Virus-guided fluorescence imaging of intraperitoneal gastric cancer cells as an alternative to cytology2014
- Author(s)
  Watanabe M, Kagawa S, Ishida M, Hori N, Kikuchi S, Kuroda S, Kishimoto H, Nishizaki M, Tazawa H, Urata Y, Fujiwara T
- Organizer
  第20回日本遺伝子治療学会
- Place of Presentation
  東京
- Year and Date
  2014-08-08
- Data Source
  KAKENHI-PROJECT-26461978
[Presentation] 蛍光発現ウイルスを用いた腹腔内がん細胞の検出技術の開発2014
- Author(s)
  渡邉めぐみ、香川俊輔、石田道拡、橋本悠里、堀　直人、菊地覚次、黒田新士、岸本浩行、西崎正彦、田澤　大、浦田泰生、藤原俊義
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26461978
[Presentation] ヒトスキルス胃癌細胞に対する腫瘍融解アデノウイルスの抗腫瘍効果2014
- Author(s)
  堀　直人、田澤　大、西崎正彦、菊地覚次、矢野修也、石田道拡、渡邉めぐみ、浦田泰生、香川俊輔、藤原俊義
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26461978
[Presentation] Virus-guided fluorescence imaging of intraperitoneal free gastric cancer cells as a potential clinical biomarker2014
- Author(s)
  Watanabe M, Kagawa S, Ishida M, Hori N, Kikuchi S, Kuroda S, Kishimoto H, Nishizaki M, Tazawa H, Fujiwara T
- Organizer
  105th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  San Diego, USA
- Year and Date
  2014-04-08
- Data Source
  KAKENHI-PROJECT-26461978
[Presentation] Tumor suppressor FHIT regulates tumor invasion of pancreatic cancer cells via inhibiting association of Ezrin and Actin cytoskeleton2013
- Author(s)
  西崎正彦, 香川俊輔, 田澤大, 藤原俊義, 黒田新士, 岸本浩行
- Organizer
  第19回日本遺伝子治療学会
- Place of Presentation
  ホテルグランヴィア岡山
- Year and Date
  2013-07-05
- Data Source
  KAKENHI-PROJECT-23592009
[Presentation] Telomerase-specific oncolytic adenovirus OBP-301 kills quiescent peritonially disseminated cancer cells2013
- Author(s)
  Yano S, Tazawa H, Kishimoto H, Fujiwara T, Hoffman RM
- Organizer
  104th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25462057
[Presentation] Tumor suppressor FHIT regulates tumor invasion of pancreatic cancer cells via inhibiting association of Ezrin and Actin cytoskeleton2013
- Author(s)
  西崎正彦　田澤大　黒田新士　岸本浩行　香川俊輔　藤原俊義
- Organizer
  第19回日本遺伝子治療学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-23592009
[Presentation] A novel adenovirus-based CTC detection technique and its clinical applications2013
- Author(s)
  Tazawa H, Takakura M, Katagiri N
- Organizer
  第19回日本遺伝子治療学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-25462057
[Presentation] "HER2遺伝子導入技術を用いたHER2陰性癌細胞に対する分子標的光免疫療法"2013
- Author(s)
  石田道拡，香川俊輔，下山京子，竹原清人，野間和広，田澤　大，黒田新士，岸本浩行，田邊俊介，松岡順治，小林久隆，藤原俊義
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-25462021
[Presentation] 腫瘍融解ウイルス療法におけるE2F1誘導性マイクロRNAの腫瘍抑制的機能2013
- Author(s)
  田澤　大、長谷井　嬢、大西哲平、矢野修也、香川俊輔、藤原俊義
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25462057
[Presentation] A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumor-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression2013
- Author(s)
  Tazawa H, Yamasaki Y, Hashimoto Y, Kuroda S, Yano S, Yoshida R, Uno F, Mizuguchi H, Ohtsuru A, Urata Y, Kagawa S, Fujiwara T
- Organizer
  第19回日本遺伝子治療学会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-25462057
[Presentation] Cytotoxic effect of photosensitive fluorescent protein KillerRed-expressing adenovirus against human cancer cells2013
- Author(s)
  Takehara K, Tazawa H, Hashimoto Y, Kishimoto H, Narii N, Mizuguchi H, Fujiwara T
- Organizer
  104th Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25462057
[Presentation] Virally tagging of HER2 extracellular domain sensitizes her2-negative gastric cancer cells to Trastuzumab-based photoimmunotherapy.2013
- Author(s)
  Kagawa S, Shimoyama K, Tazawa H, Hashimoto Y, Takehara K, Kuroda S, Kishimoto H, Nishizaki M, Kobayashi H, Fujiwara T
- Organizer
  the 10th International Gastric Cancer Congress
- Place of Presentation
  ヴェローナ、イタリア
- Data Source
  KAKENHI-PROJECT-25462021
[Presentation] 蛍光標識による血中遊離癌細胞のLiquid Biopsy技術のバイオマーカー解析への応用2013
- Author(s)
  重安邦俊,橋本悠里,竹原清人,宇野太,永坂岳司,田澤大,香川俊輔,浦田泰生,藤原俊義
- Organizer
  第51回日本癌治療学会学術集会
- Place of Presentation
  京都市
- Year and Date
  2013-10-26
- Data Source
  KAKENHI-PROJECT-23591932
[Presentation] テロメラーゼ活性を指標とする血中遊離癌細胞の高感度検出法の開発と遺伝子解析技術への応用2013
- Author(s)
  重安邦俊,橋本悠里,宇野太,永坂岳司,田澤大,香川俊輔,水口裕之,浦田泰生,藤原俊義
- Organizer
  第113回日本外科学会定期学術集会
- Place of Presentation
  福岡市
- Year and Date
  2013-04-13
- Data Source
  KAKENHI-PROJECT-23591932
[Presentation] A simple detection system for viable circulating tumor cells using genetically bioengineered adenovirus2012
- Author(s)
  Tazawa H
- Organizer
  4th World Circulating Tumor Cell Summit
- Place of Presentation
  Berlin (Germany)
- Year and Date
  2012-04-25
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] 腫瘍特異的制限増殖型アデノウイルスを用いた血液循環腫瘍細胞の遺伝子解析技術の開発2012
- Author(s)
  重安邦俊,橋本悠里,宇野太 ,永坂岳司,田澤大,香川俊輔,水口裕之,浦田泰生,藤原俊義
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロントイン札幌
- Year and Date
  2012-09-19
- Data Source
  KAKENHI-PROJECT-23659651
[Presentation] Preclinical evaluation of cytotoxic effect of photosensitive fluorescent protein in human cancer cells2012
- Author(s)
  Tazawa H, Sasaki T, Hashimoto Y, Kikuchi S, Kishimoto H, Mizuguchi H, Fujiwara T
- Organizer
  103rd Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Chicago (USA)
- Year and Date
  2012-04-04
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] New method for investigating genetic mutations of circulating tumor cells using a telomerase-specific replication-competent adenovirus2012
- Author(s)
  Shigeyasu K, Hashimoto Y, Kagawa S, Uno F, Tazawa H, Nagasaka T, Kyo S, Mizuguchi H, Urata Y, Fujiwara T
- Organizer
  第18回日本遺伝子治療学会年次学術集会
- Place of Presentation
  ホテル熊本テルサ
- Year and Date
  2012-06-29
- Data Source
  KAKENHI-PROJECT-23659651
[Presentation] A highly sensitive detection system of genetic alterations in circulating tumor cells using a telomerase-specific replication-competent adenovirus2012
- Author(s)
  Shigeyasu K, Hashimoto Y, Morikawa T, Mori Y, Sun DS, Kagawa S, Uno F, Tazawa H,Nagasaka T, Kyo S, Mizuguchi H, Urata Y, Fujiwara T
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  米国シカゴ
- Year and Date
  2012-04-02
- Data Source
  KAKENHI-PROJECT-23659651
[Presentation] p53 関連アポトーシス経路の誘導はヒト骨肉腫細胞における腫瘍融解アデノウイルスに対する抵抗性を減弱する2012
- Author(s)
  長谷井嬢、佐々木剛、田澤大、橋本悠里、国定俊之、浦田泰生、尾崎敏文、藤原俊義
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-21
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] Telomerase-specific oncolytic adenovirus suppresses the stem-like properties of CD133+ human gastric cancer MKN45 cells through microRNA modulation2012
- Author(s)
  Onishi T, Tazawa H, Yano S, Hashimoto Y, Kikuchi S, Shigeyasu K, Osaki S, Kagawa S, Fujiwara T
- Organizer
  第18回日本遺伝子治療学会
- Place of Presentation
  熊本
- Year and Date
  2012-06-28
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] Bioengineered oncolytic adenovirus induces autophagic cell death through an E2F1-microRNA-7-epidermal growth factor receptor axis2011
- Author(s)
  Hiroshi Tazawa
- Organizer
  102nd Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Orlando
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] Oncolytic adenovirus inhibits the cancer-stem cell properties through microRNA modulation2011
- Author(s)
  Tazawa H, Onishi T, Yano S, Urata Y, Fujiwara T
- Organizer
  8th International Symposium on Minimal Residual Cancer
- Place of Presentation
  大阪
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] Oncolytic adenovirus induces autophagic cell death through microRNA-7-mediated suppression of EGFR in human cancer cells2011
- Author(s)
  Tazawa H, Yano S, Yoshida R, Urata Y, Fujiwara T
- Organizer
  第16回日本遺伝子治療学会
- Place of Presentation
  宇都宮
- Year and Date
  2011-07-03
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] 胃癌幹細胞に対するテロメラーゼ特異的腫瘍融解ウイルス治療2011
- Author(s)
  香川俊輔, 矢野修也, 田澤大, 橋本悠里, 宇野太, 岸本浩行, 西崎正彦, 浦田泰生, 藤原俊義
- Organizer
  第49回日本癌治療学会学術集会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Data Source
  KAKENHI-PROJECT-23591932
[Presentation] ヒト癌細胞におけるマイクロRNAを介したオートファジー細胞死の誘導分子機構2011
- Author(s)
  田澤大、矢野修也、吉田亮介、浦田泰生、藤原俊義
- Organizer
  第29回日本ヒト細胞学会
- Place of Presentation
  富山
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] Bioengineered oncolytic adenovirus induces autophagic cell death through an E2F1-microRNA-7-epidermal growth factor receptor axis2011
- Author(s)
  Tazawa H, Yano S, Yoshida R, Urata Y, Fujiwara T
- Organizer
  102nd Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Orlando (USA)
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] Oncolytic adenovirus inhibits the cancer stem cell properties through microRNA modulation2011
- Author(s)
  Hiroshi Tazawa
- Organizer
  8th International Symposium on Minimal Residual Cancer
- Place of Presentation
  大阪
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] Oncolytic adenovirus induces autophagic cell death through microRNA-7-mediated suppression of EGFR in human cancer cells.2010
- Author(s)
  Hiroshi Tazawa
- Organizer
  第16回日本遺伝子治療学会
- Place of Presentation
  宇都宮
- Year and Date
  2010-07-03
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] E2F1-mediated microRNA-7 upregulation induces autophagic cell death-through EGFR suppression during adenovirus infection.2010
- Author(s)
  Hiroshi Tazawa
- Organizer
  第69回日本癌学会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] アデノウイルス感染に伴うE2F1 の活性化によるマイクロRNA-7 の発現誘導とオートファジー細胞死の制御機構2010
- Author(s)
  田澤大、矢野修也、吉田亮介、浦田泰生、藤原俊義
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] Preclinical Evaluation of Cytotoxic Effect of Photosensitive Fluorescent Protein in Human Cancer Cells.
- Author(s)
  Hiroshi Tazawa
- Organizer
  103rd Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] A Simple Detection System for Viable Circulating Tumor Cells Using Genetically Bioengineered Adenovirus.
- Author(s)
  Hiroshi Tazawa
- Organizer
  4th World Circulating Tumor Cell Summit
- Place of Presentation
  Berlin, Germany
- Data Source
  KAKENHI-PROJECT-22791310
[Presentation] Novel combination therapy of adenoviral gene transfer of HER2-extracellular domain and trastuzumab-based photoimmunotherapy for HER2 negative cancer cells
- Author(s)
  Ishida M, Kagawa S, Shimoyama K, Takehara K, Noma K, Tanabe S, Tazawa H, Matsuoka J, Kobayashi H, Fujiwara T
- Organizer
  2014　Annual Meeting of the American Association for Cancer Research
- Place of Presentation
  米国　サンディエゴ
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25462021
[Presentation] ウイルスを用いたHER２陰性胃癌の強制的HER2標識化とTrastuzumabによる分子標的光免疫療法
- Author(s)
  香川俊輔, 石田道拡, 田澤　大, 下山京子, 竹原清人, 野間和広, 渡辺めぐみ, 田辺俊介, 小林久隆, 藤原俊義
- Organizer
  第70回日本消化器外科学会総会
- Place of Presentation
  福島県郡山市
- Year and Date
  2014-07-16 – 2014-07-18
- Data Source
  KAKENHI-PROJECT-25462021

1. FUJIWARA Toshiyoshi (00304303)

# of Collaborated Projects: 9 results

# of Collaborated Products: 43 results
2. KAGAWA Shunsuke (00362971)

# of Collaborated Projects: 6 results

# of Collaborated Products: 32 results
3. NISHIZAKI Masahiko (30379789)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
4. NAGASAKA Takeshi (30452569)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
5. KURODA Shinji (60633758)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
6. 吉田龍一 (80534768)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. 魚谷弘二 (30708087)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 吉田晶 (00910514)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 藤原智洋 (80639211)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
10. 小田孔明 (10751836)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. SHIGEYASU Kunitoshi

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
12. UNO Futoshi (90572503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. Tanabe Shunsuke (20534770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
14. OYAMA Takanori (10380164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
15. Noma Kazuhiro (10534761)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. SHIRAKAWA Yasuhiro (60379774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. OHARA Toshiaki (40623533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. 尾崎敏文 (40294459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
19. 三澤治夫 (60448222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 鷹取亮 (80992370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 篠原健介 (40644381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HASHIMOTO Yuuri

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
23. KATSUBE Ryoichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. MATSYBARA Daisuk

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. UMEDA Yuzo

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
26. 西田直生志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 末次淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 国定俊之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
29. 岸本浩行

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
30. 吉田一博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 水口裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
32. 垣内慶彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 岡田太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 母里淑子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 齋藤卓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tazawa Hiroshi 田澤 大

TAZAWA Hiroshi 田澤 大

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Exploration of metabolic factors to inhibit tumor-specific p53 gene therapy in pancreatic cancerPrincipal Investigator

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Preclinical study of tumor-specific p53 gene therapy against refractory pancreatic cancerPrincipal Investigator

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Development of novel microRNA-based therapy against KRAS/BRAF-mutant colorectal cancerPrincipal Investigator

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Tazawa Hiroshi 田澤大

TAZAWA Hiroshi 田澤大

[Book] 次世代がん治療（第3章第1節）2017