Fujiwara Tomohiro 藤原智洋

Researcher Number	80639211
Other IDs
Affiliation (Current)	2023: 岡山大学, 大学病院, 講師
Affiliation (based on the past Project Information) *help	2023: 岡山大学, 大学病院, 助教 2023: 岡山大学, 大学病院, 講師 2021 – 2022: 岡山大学, 医歯薬学域, 助教 2016 – 2020: 岡山大学, 医歯薬学総合研究科, 助教 2015: 岡山大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery Except Principal Investigator Basic Section 56020:Orthopedics-related / Orthopaedic surgery / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 肉腫 / 腫瘍関連マクロファージ / 腫瘍随伴マクロファージ / 免疫療法 / トランスレーショナルリサーチ / 核酸 / 癌 / 治療標的 / バイオマーカー / microRNA / エクソソーム … More Except Principal Investigator … More 肉腫 / 軟部肉腫 / 骨軟部腫瘍 / エクソソーム / バイオマーカー / ウイルス治療 / 腫瘍随伴マクロファージ / 腫瘍微小環境 / 体液診断 / exosome / 骨軟部肉腫 / 放射線治療 / 腫瘍融解アデノウイルス / 腫瘍浸潤リンパ球 / 液性因子 / 微小環境 / マクロファージ / がん遺伝子パネル / 脊椎脊髄腫瘍 / 体液分子診断 / サイトカイン / リキッドバイオプシー / 循環分子 / 新規治療 / 転移メカニズム / micorRNA / 治療 / 浸潤 / 転移 / exsome / microRNA / 悪性骨軟部腫瘍 / 放射線治療併用 / 臨床応用 / 骨肉腫 / 軟部腫瘍 / 悪性腫瘍 / Ewing 肉腫 / Liquid biopsy / liquid biopsy / 併用療法 / 骨・軟部肉腫 / CAR / 骨軟部悪性腫瘍 / テロメスキャン / テロメライシン / 肉腫治療 Less

脊椎脊髄腫瘍に対する腫瘍融解ウイルス療法の確立
- Principal Investigator
  
  魚谷弘二
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
がん遺伝子パネル検査の全国登録データを利用した悪性骨軟部腫瘍の網羅的遺伝子解析
- Principal Investigator
  
  國定俊之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
Development of combination tumor microenvironment-targeted therapy and conventional chemotherapy for soft-tissue sarcoma
- Principal Investigator
  
  近藤彩奈
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
肉腫における腫瘍内免疫環境の細胞間ネットワーク機構解明を基盤とした治療法の開発
- Principal Investigator
  
  尾崎敏文
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Okayama University
肉腫における体液分子診断技術の統合的開発と循環分子の新規治療標的としての検証
- Principal Investigator
  
  尾崎敏文
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
軟部肉腫における腫瘍由来液性因子に惹起される微小環境ネットワークの包括的解明
- Principal Investigator
  
  畑利彰
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Okayama University
A novel immunotherapeutic approach for sarcomas by targeting tumor-associated macrophagesPrincipal Investigator
- Principal Investigator
  
  藤原智洋
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
Development of diagnostic techniques using liquid biopsy and identification of novel mechanisms of tumor progression through circulating molecules in sarcoma
- Principal Investigator
  
  Ozaki Toshifumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Okayama University
Elucidation of the molecular mechanism of invasion and metastasis of human sarcomas via tumor-derived exosomes and its applicaion to novel therapies.
- Principal Investigator
  
  Morita Takuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Okayama University
  National Hospital Organization Shikoku Cancer Center
Identification of molecular targets for liquid biopsy in patients with bone and soft tissue sarcoma
- Principal Investigator
  
  Ozaki Toshifumi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Okayama University
Local adjuvant therapy on bone and soft tissue sarcoma by combination of telomerase-specific oncolytic adenovirus with radiotherapy
- Principal Investigator
  
  Kunisada Toshiyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Okayama University
肉腫の形成および転移に関与する腫瘍由来エクソソームを介した分子機構の解明と制御Principal Investigator
- Principal Investigator
  
  藤原智洋
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Okayama University
Preclinical analysis of oncolytic adenovirus infection to patient-derived tumor specimens of bone and soft tissue tumors
- Principal Investigator
  
  Koji Uotani
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  National Hospital Organization Shikoku Cancer Center
  Okayama University
Development of novel treatment strategy against bone and soft tissue sarcoma by combination of tumor-specific oncolytic adenovirus and radiotherapy
- Principal Investigator
  
  Sugiu Kazuhisa
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Okayama University

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] 骨･軟部腫瘍のマネジメント(その1) Ⅱ.診　断 2.組織･遺伝子診断骨･軟部腫瘍におけるリキッドバイオプシーの開発2021
- Author(s)
  藤原智洋、中田英二、国定俊之、尾﨑敏文
- Journal Title
  
  別冊整形外科
  
  Volume: 1 Issue: 79 Pages: 63-69
- DOI
  10.15106/j_besei79_63
- ISSN
  0287-1645
- Year and Date
  2021-04-20
- Data Source
  KAKENHI-PROJECT-19H03784
[Journal Article] Liquid Biopsy Targeting Monocarboxylate Transporter 1 on the Surface Membrane of Tumor-Derived Extracellular Vesicles from Synovial Sarcoma2021
- Author(s)
  Yokoo Suguru、Fujiwara Tomohiro、Yoshida Aki、Uotani Koji、Morita Takuya、Kiyono Masahiro、Hasei Joe、Nakata Eiji、Kunisada Toshiyuki、Iwata Shintaro、Yonemoto Tsukasa、Ueda Koji、Ozaki Toshifumi
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 8 Pages: 1823-1823
- DOI
  10.3390/cancers13081823
- NAID
  120007037389
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03784, KAKENHI-PROJECT-19K09650, KAKENHI-PROJECT-19K18466
[Journal Article] Role of Tumor-Associated Macrophages in Sarcomas2021
- Author(s)
  Fujiwara Tomohiro、Healey John、Ogura Koichi、Yoshida Aki、Kondo Hiroya、Hata Toshiaki、Kure Miho、Tazawa Hiroshi、Nakata Eiji、Kunisada Toshiyuki、Fujiwara Toshiyoshi、Ozaki Toshifumi
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 5 Pages: 1086-1086
- DOI
  10.3390/cancers13051086
- NAID
  120007008531
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03784, KAKENHI-PROJECT-21K16709
[Journal Article] CSF1/CSF1R Signaling Inhibitor Pexidartinib (PLX3397) Reprograms Tumor-Associated Macrophages and Stimulates T-cell Infiltration in the Sarcoma Microenvironment2021
- Author(s)
  Fujiwara Tomohiro、Yakoub Mohamed A.、Chandler Andrew、Christ Alexander B.、Yang Guangli、Ouerfelli Ouathek、Rajasekhar Vinagolu K.、Yoshida Aki、Kondo Hiroya、Hata Toshiaki、Tazawa Hiroshi、Dogan Yildirim、Moore Malcolm A.S.、Fujiwara Toshiyoshi、Ozaki Toshifumi、Purdue Ed、Healey John H.
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 20 Issue: 8 Pages: 1388-1399
- DOI
  10.1158/1535-7163.mct-20-0591
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03784, KAKENHI-PROJECT-21K16709
[Journal Article] Immunotherapy for sarcomas2021
- Author(s)
  Nakata Eiji、Fujiwara Tomohiro、Kunisada Toshiyuki、Ito Tastuo、Takihira Shota、Ozaki Toshifumi
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 51 Issue: 4 Pages: 523-537
- DOI
  10.1093/jjco/hyab005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03784
[Journal Article] Clinical relevance and functional significance of cell-free microRNA-1260b expression profiles in infiltrative myxofibrosarcoma2020
- Author(s)
  Takuya Morita, Tomohiro Fujiwara, Aki Yoshida, Koji Uotani, Masahiro Kiyono, Suguru Yokoo, Joe Hasei, Toshiyuki Kunisada, Toshifumi Ozaki
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 9414-9414
- DOI
  10.1038/s41598-020-66120-8
- NAID
  120006883488
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09650, KAKENHI-PROJECT-19K18466, KAKENHI-PROJECT-19H03784
[Journal Article] A rare manifestation of extraskeletal myxoid chondrosarcoma with a huge expanding hematoma2019
- Author(s)
  Omori Toshinori、Fujiwara Tomohiro、Kunisada Toshiyuki、Takeda Ken、Hasei Joe、Yoshida Aki、Yanai Hiroyuki、Ozaki Toshifumi
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: 24 Issue: 2 Pages: 377-381
- DOI
  10.1016/j.jos.2016.12.011
- NAID
  120007004863
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10862
[Journal Article] Mini-open excision of osteoid osteoma using intraoperative O-arm/Stealth navigation2019
- Author(s)
  Fujiwara Tomohiro、Kunisada Toshiyuki、Takeda Ken、Hasei Joe、Nakata Eiji、Mochizuki Yusuke、Kiyono Masahiro、Yoshida Aki、Ozaki Toshifumi
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: 24 Issue: 2 Pages: 337-341
- DOI
  10.1016/j.jos.2018.09.017
- NAID
  120007004864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10862
[Journal Article] Intraoperative O-arm-navigated resection in musculoskeletal tumors2018
- Author(s)
  Fujiwara Tomohiro、Kunisada Toshiyuki、Takeda Ken、Hasei Joe、Nakata Eiji、Nakahara Ryuichi、Yoshida Aki、Ozaki Toshifumi
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: 23 Issue: 6 Pages: 1045-1050
- DOI
  10.1016/j.jos.2018.06.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10862
[Journal Article] Clinical and Functional Significance of Intracellular and Extracellular microRNA-25-3p in Osteosarcoma2018
- Author(s)
  Yoshida A, Fujiwara T, Uotani K, Morita T, Kiyono M, Yokoo S, Hasei J, Nakata E, Kunisada T, Ozaki T.
- Journal Title
  
  Acta Medica Okayama
  
  Volume: 72 Issue: 2 Pages: 165-174
- DOI
  10.18926/AMO/55857
- NAID
  120006459963
- URL
  https://ousar.lib.okayama-u.ac.jp/55857
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05449
[Journal Article] Role of zoledronic acid in oncolytic virotherapy: Promotion of antitumor effect and prevention of bone destruction2017
- Author(s)
  Yamakawa Yasuaki、Tazawa Hiroshi、Hasei Joe、Osaki Shuhei、Omori Toshinori、Sugiu Kazuhisa、Komatsubara Tadashi、Uotani Kouji、Fujiwara Tomohiro、Yoshida Aki、Kunisada Toshiyuki、Urata Yasuo、Kagawa Shunsuke、Ozaki Toshifumi、Fujiwara Toshiyoshi
- Journal Title
  
  Cancer Science
  
  Volume: 108 Issue: 9 Pages: 1870-1880
- DOI
  10.1111/cas.13316
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10862, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-16H05416, KAKENHI-PROJECT-15K10446
[Journal Article] Clinical significance of circulating miR-25-3p as a novel diagnostic and prognostic biomarker in osteosarcoma2017
- Author(s)
  Fujiwara T, Uotani K, Yoshida A, Morita T, Nezu Y, Kobayashi E, Yoshida A5, Uehara T1, Omori T1, Sugiu K1, Komatsubara T, Takeda K, Kunisada T, Kawamura M, Kawai A, Ochiya T, Ozaki T
- Journal Title
  
  Oncotarget
  
  Volume: - Issue: 20 Pages: 33375-33392
- DOI
  10.18632/oncotarget.16498
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10050, KAKENHI-PROJECT-16K20054, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-16H05449
[Journal Article] Circulating MicroRNA-92b-3p as a Novel Biomarker for Monitoring of Synovial Sarcoma2017
- Author(s)
  Uotani Koji、Fujiwara Tomohiro、Yoshida Aki、Iwata Shintaro、Morita Takuya、Kiyono Masahiro、Yokoo Suguru、Kunisada Toshiyuki、Takeda Ken、Hasei Joe、Numoto Kunihiko、Nezu Yutaka、Yonemoto Tsukasa、Ishii Takeshi、Kawai Akira、Ochiya Takahiro、Ozaki Toshifumi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 14634-14634
- DOI
  10.1038/s41598-017-12660-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-16H05449
[Journal Article] Ablation of MCL1 expression by virally induced microRNA-29 reverses chemoresistance in human osteosarcomas.2016
- Author(s)
  Osaki S, Tazawa H, Hasei J, Yamakawa Y, Omori T, Sugiu K, Komatsubara T, Fujiwara T, Sasaki T, Kunisada T,
- Journal Title
  
  Sci Rep.
  
  Volume: 30(6) Issue: 1 Pages: 28953-28953
- DOI
  10.1038/srep28953
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-16H05416, KAKENHI-PROJECT-16K10862
[Presentation] Pexidartinibの骨肉腫に対する前臨床的検討：CSF-1/CSF-1R阻害は肉腫微小環境の免疫細胞構成分画を変化させ抗腫瘍効果を発揮する2021
- Author(s)
  藤原智洋, Mohamed Yakoub, Andrew Chandler, Vinagolu K. Rajasekhar, Ouathek Ouerfelli, 吉田晶、近藤宏也、畑利彰、佐藤浩平、棏平将太、中田英二,　国定俊之,　尾﨑敏文,　Ed Purdue, John Healey
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-21K16709
[Presentation] 腫瘍関連マクロファージを誘導するCSF-1の分泌と血中発現の解析　浸潤性軟部肉腫における検討2021
- Author(s)
  畑利彰, 藤原智洋, 吉田晶, 近藤彩奈, 片山晴喜, 佐藤浩平, 近藤宏也, たき平将太, 中田英二, 国定俊之, 尾崎敏文
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03784
[Presentation] Pexidartinibの骨肉腫に対する前臨床的検討　CSF-1/CSF-1R阻害は肉腫微小環境の免疫細胞構成分画を変化させ抗腫瘍効果を発揮する2021
- Author(s)
  藤原智洋, Yakoub Mohamed, 吉田晶, 近藤宏也, 畑利彰, 佐藤浩平, たき平将太, 中田英二, 国定俊之, 尾崎敏文, Healey John
- Organizer
  第36回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03784
[Presentation] Establishment of Liquid Biopsy Targetting Exosomes Derived from Synovial Sarcoma2020
- Author(s)
  Suguru Yokoo, Tomohiro Fujiwara, Koji Uotani, Aki Yoshida, Takuya Morita, Masahiro Kiyono, Joe Hasei, Eiji Nakata, Toshiyuki Kunisada, Toshifumi Ozaki
- Organizer
  Orthopaedic Research Society 2020 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03784
[Presentation] Combination of PD-1 blockade Immunotherapy and Telomerase-Specific Oncolytic Virotherapy in Osteosarcoma2019
- Author(s)
  Yusuke Mochizuki, Hiroshi Tazawa, Miho Kure, Koji Demiya, Joe Hasei, Toshiyuki Kunisada, Yasuo Urata, Toshiyoshi Fujiwara, Toshifumi Ozaki
- Organizer
  Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] Detection of exosomal markers in patients with synovial sarcoma2019
- Author(s)
  Suguru Yokoo; Tomohiro Fujiwara; Koji Uotani; Aki Yoshida; Takuya Morita; Masahiro Kiyono; Toshiyuki Kunisada; Yusuke Yoshioka; Koji Ueda; Takahiro Ochiya; Toshifumi Ozaki
- Organizer
  ORS 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05449
[Presentation] The role of exosomes in osteosarcoma cell migration, invasion and lung metastasis2019
- Author(s)
  Masahiro Kiyono; Tomohiro Fujiwara; Aki Yoshida; Suguru Yokoo; Koji Demiya; Yusuke Mochizuki; Joe Hasei; Eiji Nakata; Toshiyuki Kunisada; Toshiyuki Ozaki
- Organizer
  ORS 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05449
[Presentation] 腫瘍由来エクソソームを標的とした滑膜肉腫におけるリキッドバイオプシーの開発2019
- Author(s)
  横尾賢、藤原智洋、吉田晶、清野正普、望月雄介、出宮光二、上甲良二、久禮美穂、尾崎敏文
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03784
[Presentation] Clinical and functional significance of single circulating and cellular microRNA dysregulation in osteosarcoma2019
- Author(s)
  Aki Yoshida; Tomohiro Fujiwara; Koji Uotani; Takuya Morita; Masahiro Kiyono; Suguru Yokoo; Joe Hasei; Eiji Nakata; Toshiyuki Kunisada; Toshifumi Ozaki
- Organizer
  ORS 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05449
[Presentation] 骨肉腫由来エクソソームが関与する骨肉腫細胞転移の機序についての検討2019
- Author(s)
  清野正普、藤原智洋、吉田晶、横尾賢、出宮光二、望月雄介、上甲良二、長谷井嬢、中田英二、国定俊之、尾崎敏文
- Organizer
  第34回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-19H03784
[Presentation] p53-armed oncolytic virotherapy promotes immunogenic cell death in human osteosarcoma2019
- Author(s)
  Koji Demiya, Hiroshi Tazawa, Miho Kure, Yusuke Mochizuki, Joe Hasei Toshiyuki Kunisada, Yasuo Urata, Toshiyoshi Fujiwara, Toshifumi Ozaki
- Organizer
  Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] Resection Of Soft Tissue Sarcoma With Adequate Wide Margin Can Lead To Good Local Control Without Adjuvant Radiation Therapy2018
- Author(s)
  oshiyuki Kunisada, Tomohiro Fujiwara, Joe Hasei, Toshifumi Ozaki
- Organizer
  American Academy of Orthopedic Surgery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] 骨肉腫における細胞内外の単一microRNAの機能について2018
- Author(s)
  吉田晶, 藤原智洋, 魚谷弘二, 森田卓也, 清野正普, 横尾賢, 長谷井嬢, 国定俊之, 尾崎敏文
- Organizer
  第77回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-16H05449
[Presentation] 軟部肉腫に対するp53発現腫瘍融解アデノウイルスによるアポトーシス抑制遺伝子発現の制御を介した放射線感受性増感作用の検討2018
- Author(s)
  小松原将、出宮光二、田澤大、望月雄介、長谷井嬢、中田英二、国定俊之、浦田泰生、藤原俊義、尾﨑敏文
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] 滑膜肉腫由来exosomeの特定とマーカーの網羅的解析2018
- Author(s)
  横尾賢, 藤原智洋, 吉田晶, 清野正普, 望月雄介, 出宮光二, 長谷井嬢, 国定俊之, 吉岡祐亮, 植田幸嗣, 落谷孝広, 尾崎敏文
- Organizer
  第77回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-16H05449
[Presentation] 骨肉腫に対するp53誘導性腫瘍融解ウイルス療法による免疫原性細胞死の誘導効果2018
- Author(s)
  出宮光二、田澤大、望月雄介、小松原将、長谷井嬢、中田英二、国定俊之、浦田泰生、藤原俊義、尾﨑敏文
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] 骨肉腫に対する抗PD-1抗体の効果増強を目指した腫瘍融解アデノウイルスを用いた複合免疫療法2018
- Author(s)
  望月雄介、田澤大、出宮光二、小松原将、長谷井嬢、中田英二、国定俊之、浦田泰生、藤原俊義、尾﨑敏文
- Organizer
  第32回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] Molecular radiosensitizing effect of p53-armed telomerase-specific oncolytic adenovirus in soft tissue sarcoma2018
- Author(s)
  Tadashi Komatsubara, Hiroshi Tazawa, Kouji Demiya, Yusuke Mochizuki, Kazuhisa Sugiu, Toshinori Omori, Yasuaki Yamakawa, Syuhei Osaki, Joe Hasei, Tomohiro Fujiwara, Eiji Nakata, Toshiyuki Kunisada, Yasuo Urata, Toshiyoshi Fujiwara, Toshifumi Ozaki
- Organizer
  Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] 骨肉腫細胞内と分泌エクソソーム内におけるmicroRNA発現プロファイリングの相違と患者循環エクソソーム内の発現評価2017
- Author(s)
  清野正普, 藤原智洋, 魚谷弘二, 吉田晶, 森田卓也, 杉生和久, 小松原将, 望月雄介, 長谷井嬢, 国定俊之, 尾崎敏文
- Organizer
  第50回日本整形外科学会骨・軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-16H05449
[Presentation] Diagnostic and Prognostic Significance of Circulating Cell-free microRNAs in Osteosarcoma2017
- Author(s)
  Tomohiro Fujiwara; Koji Uotani; Aki Yoshida; Takuya Morita; Masahiro Kiyono; Yusuke Mochizuki; Tadashi Komatsubara; Kazuhisa Sugiu; Joe Hasei; Toshiyuki Kunisada; Yutaka Nezu; Eisuke Kobayashi; Akira Kawai; Takahiro Ochiya; Toshifumi Ozaki
- Organizer
  Orthopaedic Research Society
- Place of Presentation
  サンディエゴ
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20054
[Presentation] 悪性骨・軟部腫瘍転移制御への道粘液線維肉腫における分泌型microRNAは腫瘍の浸潤性と関連しているか2017
- Author(s)
  森田卓也, 藤原智洋, 魚谷弘二, 吉田晶, 清野正普, 杉生和久, 小松原将, 望月雄介, 長谷井嬢, 国定俊之, 尾崎敏文
- Organizer
  第50回日本整形外科学会骨・軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-16H05449
[Presentation] Identification of surface marker protein by proteomic profiling of exosomes derived from Ewing sarcoma cells2017
- Author(s)
  Aki Yoshida, Tomohiro Fujiwara, Koji Uotani, Yusuke Yoshioka, Koji Ueda, Takuya Morita, Masahiro Kiyono, Kazuhisa Sugiu, Tadashi Komatsubara, Jo Hasei, Toshiyuki Kunisada, Takahiro Ochiya, Toshifumi Ozaki
- Organizer
  Orthopaedic research Society 2017 Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2017-03-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05449
[Presentation] RESECTION OF SOFT TISSUE SARCOMA WITH ADEQUATE WIDE MARGIN CAN LEAD TO GOOD LOCAL CONTROL WITHOUT ADJUVANT RADIATION THERAPY2017
- Author(s)
  Toshiyuki Kunisada, Tomohiro Fujiwara, Joe Hasei, Toshifumi Ozaki
- Organizer
  Connective Tissue Oncology Society (CTOS)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] 軟部肉腫に対する腫瘍融解アデノウイルスによる放射線治療増感効果の検討2017
- Author(s)
  小松原将　大森敏規　望月雄介　杉生和久　長谷井嬢　吉田晶　藤原智洋　国定俊之　浦田泰生　田澤大　藤原俊義　尾崎敏文
- Organizer
  第50回日本整形外科学会骨・軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-15K10446
[Presentation] ドキソルビシン耐性骨肉腫細胞に対するp53発現腫瘍融解アデノウイルスによるMDR1発現抑制を介した薬剤耐性克服機序の検討2017
- Author(s)
  杉生和久　田澤大　望月雄介　小松原将　大森敏規　山川泰明　吉田晶　長谷井嬢　藤原智洋　国定俊之　浦田泰生　藤原俊義　尾崎敏文
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] Telomerase-specific Oncolytic Adenoviral Therapy Reverses Resistance to Chemotherapy and Radiotherapy in Human Osteosarcoma2017
- Author(s)
  Yusuke Mochizuki, Tomohiro Fujiwara, Toshinori Omori, Shuhei Osaki, Joe Hasei, Kazuhisa Sugiu, Tadashi Komatsubara,Tsuyoshi Sasaki, Toshiyuki Kunisada, Hitoshi Tazawa, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara, Toshifumi Ozaki
- Organizer
  Orthopaedic Research Society 2017 Annual Meeting
- Place of Presentation
  San Diego, California, USA
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10446
[Presentation] p53発現腫瘍融解アデノウイルスによる軟部肉腫に対する放射線治療併用効果の検討2017
- Author(s)
  小松原将　望月雄介　杉生和久　大森敏規長谷井嬢　吉田晶　藤原智洋　国定俊之　浦田泰生　田澤大　藤原俊義　尾崎敏文
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] Ewing肉腫における腫瘍由来exosomeを標的としたliquid biopsy法の確立2017
- Author(s)
  魚谷弘二, 藤原智洋, 吉田晶, 岩田慎太郎, 森田卓也, 清野正普, 長谷井嬢, 国定俊之, 吉岡祐亮, 植田幸嗣, 落谷孝広, 尾崎敏文
- Organizer
  第50回日本整形外科学会骨・軟部腫瘍学術集会
- Data Source
  KAKENHI-PROJECT-16H05449
[Presentation] TELOMERASE-SPECIFIC ONCOLYTIC ADENOVIRUS ENHANCES RADIATION-INDUCED APOPTOSIS IN SOFT TISSUE SARCOMA CELLS BY ABLATING ANTI-APOPTIC MCL1 EXPRESSION2017
- Author(s)
  Tadashi Komatsubara, Hiroshi Tazawa, Yusuke Mochizuki, Kazuhisa Sugiu, Toshinori Omori, Yasuaki Yamakawa,Syuhei Osaki, Joe Hasei, Tomohiro Fujiwara, Toshiyuki Kunisada, Yasuo Urata, Toshiyoshi Fujiwara, Toshifumi Ozaki
- Organizer
  Connective Tissue Oncology Society Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10446
[Presentation] Molecular radiosensitization in soft tissue sarcomas by telomerase-specific oncolytic adenovirus2017
- Author(s)
  Tadashi Komatsubara, Toshinori Omori, Hiroshi Tazawa, Kazuhisa Sugiu, Yusuke Mochizuki, Yasuaki Yamakawa,Syuhei Osaki, Joe Hasei, Tomohiro Fujiwara, Toshiyuki Kunisada, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara
- Organizer
  American Association for CancerResearch 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10446
[Presentation] 腫瘍融解ウイルスの骨軟部腫瘍組織に対する感染効率の評価2017
- Author(s)
  吉田晶魚谷弘二藤原智洋長谷井嬢森田卓也清野正普小松原将望月雄介国定俊之藤原俊義尾崎敏文
- Organizer
  日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-15K10444
[Presentation] 臨床検体を用いた腫瘍融解アデノウイルスの骨軟部腫瘍への適応に関する検討臨床検体を用いた腫瘍融解アデノウイルスの骨軟部腫瘍への適応に関する検討2016
- Author(s)
  吉田晶　魚谷弘二　藤原智洋　長谷井嬢　大森敏規　杉生和久　小松原将　森田卓也　清野正普　望月雄介　武田健　国定俊之　藤原俊義　尾崎敏文
- Organizer
  日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2016-10-14
- Data Source
  KAKENHI-PROJECT-15K10444
[Presentation] 軟部肉腫に対する腫瘍融解アデノウイルスと放射線治療の併用効果の検討2016
- Author(s)
  小松原将　大森泰明　杉生和久　森田卓也　魚谷弘二　吉田晶　藤原智洋　武田健　国定俊之　浦田泰生　尾崎敏文
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K10446
[Presentation] 放射線抵抗性を示す骨・軟部肉腫に対する腫瘍融解アデノウイルスの放射線増感作用2016
- Author(s)
  大森敏規,　山川泰明，長谷井嬢，田澤大,　尾崎修平,　杉生和久,　藤原智洋，国定俊之,　浦田泰生,　藤原俊義,　尾﨑敏文
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K10446
[Presentation] Radiosensitization of telomerase-targeted oncolytic adenovirus against human soft-tissue sarcoma2016
- Author(s)
  Tadashi Komatsubara, Toshinori Omori, Hiroshi Tazawa, Kazuhisa Sugiu, Yusuke Mochizuki, Yasuaki Yamakawa,Syuhei Osaki, Joe Hasei, Kouji Uotani, Tomohiro Fujiwara, Toshiyuki Kunisada, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara
- Organizer
  日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] RESECTION OF SOFT TISSUE SARCOMA WITH ADEQUATE WIDE MARGIN CAN LEAD TO GOOD LOCAL CONTROL WITHOUT ADJUVANT RADIATION THERAPY2016
- Author(s)
  T Kunisada, T Fujiwara, J Hasei, H Yanai, T Ozaki
- Organizer
  Connective Tissue Oncology Society
- Place of Presentation
  Lisbon
- Year and Date
  2016-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] 骨・軟部肉腫に対する腫瘍融解ウイルスの放射線増感作用2016
- Author(s)
  大森敏規,　山川泰明，長谷井嬢，田澤大,　尾崎修平,　杉生和久,　藤原智洋，国定俊之,　浦田泰生,　藤原俊義,　尾﨑敏文
- Organizer
  第49回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  東京ドームホテル
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-15K10446
[Presentation] A novel treatment strategy for bone and soft tissue sarcomas with combination therapy of tumor-specfic oncolytic adenovirus and radiation2016
- Author(s)
  Toshinori Omori, Yasuaki Yamakawa, Joe Hasei, Hiroshi Tazawa, Tomohiro Fujiwara, Tadashi Komatsubara, Shuhei Osaki, Tsuyoshi Sasaki, Kazuhisa Sugiu, Aki Yoshida Toshiyuki Kunisada, Toshifumi Ozaki, Toshiyoshi Fujiwara
- Organizer
  Orthopaedic Research Society 2016 Annual Meeting
- Place of Presentation
  Orland, Florida
- Year and Date
  2016-03-05
- Data Source
  KAKENHI-PROJECT-15K10446
[Presentation] Radiosensitization of telomerase-targeted oncolytic adenovirus against human soft-tissue sarcoma2016
- Author(s)
  Tadashi Komatsubara, Toshinori Omori, Hiroshi Tazawa, Kazuhisa Sugiu, Yusuke Mochizuki, Yasuaki Yamakawa,Syuhei Osaki, Joe Hasei, Kouji Uotani, Tomohiro Fujiwara, Toshiyuki Kunisada, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K10446
[Presentation] 放射線抵抗性を示す骨・軟部肉腫におけるに対する腫瘍融解アデノウイルスの放射線増感作用2016
- Author(s)
  大森敏規, 山川泰明, 長谷井嬢, 田澤大, 尾崎修平, 杉生和久, 藤原智洋, 国定俊之, 浦田泰生, 藤原俊義, 尾﨑敏文
- Organizer
  日本整形外科学会基礎学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] 骨肉腫細胞内と細胞外分泌エクソソーム内のmicroRNA発現プロファイリングはどのように異なるか2016
- Author(s)
  藤原智洋、清野正普、魚谷弘二、吉田　晶、森田卓也、杉生和久、小松原将、望月雄介、　国定俊之、尾﨑敏文
- Organizer
  日本整形外科学会基礎学術集会
- Place of Presentation
  福岡
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16K20054
[Presentation] Ewing肉腫から分泌されるexosomeの表面蛋白を利用したliquid biopsyの開発2016
- Author(s)
  望月雄介，魚谷弘二，藤原智洋，吉田晶，森田卓也，清野正普，国定俊之，吉岡裕亮，植田幸嗣，落谷孝広，尾崎敏文
- Organizer
  第31回日本整形外科学会基礎学術集会
- Place of Presentation
  福岡市
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16H05449
[Presentation] Reversal of ABC transporter-mediated chemoresistance in human osteosarcoma by oncolytic virotherapy2016
- Author(s)
  Kazuhisa Sugiu, Hiroshi Tazawa , Joe Hasei, Shuhei Osaki, Yasuaki Yamakawa, Toshinori Omori, Tadashi Komatsubara, Yusuke Mochizuki, Kouji Uotani, Tomohiro Fujiwara, Toshiyuki Kunisada, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara
- Organizer
  日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K10862
[Presentation] 骨・軟部肉腫に対する腫瘍融解アデノウイルスと放射線療法の併用効果2015
- Author(s)
  大森敏規, 山川泰明, 長谷井嬢,田澤大, 尾崎修平, 杉生和久, 藤原智洋, 国定俊之, 浦田泰生,藤原俊義, 尾﨑敏文
- Organizer
  第48回日本整形外科学会骨・軟部腫瘍学術集会
- Place of Presentation
  高松
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-15K10446
[Presentation] Radiosensitization of bone and soft tissue sarcoma cells by tumor-specific oncolytic adenovirus2015
- Author(s)
  Toshinori Omori, Yasuaki Yamakawa, Joe Hasei, Hiroshi Tazawa, Shuhei Osaki, Tsuyoshi Sasaki, Kazuhisa Sugiu, Tomohiro Fujiwara, Toshiyuki Kunisada, Toshifumi Ozaki, Toshiyoshi Fujiwara
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K10446
[Presentation] 骨・軟部肉腫に対する腫瘍融解アデノウイルスと放射線療法の併用効果2015
- Author(s)
  大森敏規, 山川泰明, 長谷井嬢,田澤大, 尾崎修平, 杉生和久, 藤原智洋, 国定俊之, 浦田泰生,藤原俊義, 尾﨑敏文
- Organizer
  第88回日本整形外科学会学術総会
- Place of Presentation
  神戸
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-15K10446
[Presentation] 骨・軟部肉腫に対する腫瘍融解アデノウイルスと放射線療法の併用効果2015
- Author(s)
  大森敏規, 山川泰明, 長谷井嬢,田澤大, 尾崎修平, 杉生和久, 藤原智洋, 国定俊之, 浦田泰生,藤原俊義, 尾﨑敏文
- Organizer
  第30回日本整形外科学会基礎学術集会
- Place of Presentation
  富山
- Year and Date
  2015-10-22
- Data Source
  KAKENHI-PROJECT-15K10446

1. Ozaki Toshifumi (40294459)

# of Collaborated Projects: 9 results

# of Collaborated Products: 52 results
2. Kunisada Toshiyuki (80346428)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. 吉田晶 (00910514)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. Koji Uotani (30708087)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
5. 杉原進介 (60314671)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 畑利彰 (50880887)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
7. 近藤彩奈 (80910512)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. Morita Takuya (10743007)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
9. 藤原俊義 (00304303)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
10. 清野正普 (60756097)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
11. 横尾賢 (00781204)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
12. 近藤宏也 (40846911)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. Sugiu Kazuhisa (10708340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
14. 長谷井嬢 (40636213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 田澤大 (90415513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 三澤治夫 (60448222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 小田孔明 (10751836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 中田英二 (10649304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. OCHIYA Takahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
20. YOSHIOKA Yusuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
21. UEDA Koji

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
22. UEHARA Takenori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. MATSYBARA Daisuk

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. KAWAMURA Machiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. IWATA Shintaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 国定俊之

# of Collaborated Projects: 0 results

# of Collaborated Products: 44 results
27. 川井章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 王谷英達

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 米本司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujiwara Tomohiro 藤原 智洋

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A novel immunotherapeutic approach for sarcomas by targeting tumor-associated macrophagesPrincipal Investigator

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肉腫の形成および転移に関与する腫瘍由来エクソソームを介した分子機構の解明と制御Principal Investigator

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[Journal Article] 骨･軟部腫瘍のマネジメント(その1) Ⅱ.診 断 2.組織･遺伝子診断 骨･軟部腫瘍におけるリキッドバイオプシーの開発2021

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Fujiwara Tomohiro 藤原智洋

[Journal Article] 骨･軟部腫瘍のマネジメント(その1) Ⅱ.診　断 2.組織･遺伝子診断骨･軟部腫瘍におけるリキッドバイオプシーの開発2021