SAKASEGAWA Yuji 逆瀬川裕二

Researcher Number	90418616
Affiliation (based on the past Project Information) *help	2012 – 2014: 東北大学, 医学(系)研究科(研究院), 助教 2007 – 2008: 東北大学, 大学院・医学系研究科, 助教
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Neurology
Keywords	Principal Investigator インビトロ再構成系 / 立体構造変換 / 複製 / Hsp90 / 高次構造変換 / プリオン Except Principal Investigator 構造活性相関 / Aβ / プリオン / 病態 … More / 治療 / アミロイド親和性化合物 / アルツハイマー病 / プリオン病 / 治療学 / 神経病態生化学 Less

Reconstitution of the cellular prion protein unfolding system using Hsp90 and its associated proteinsPrincipal Investigator
- Principal Investigator
  
  SAKASEGAWA Yuji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Tohoku University
Research of therapeutic strategy applying to both prion diseases and Alzheimer's disease
- Principal Investigator
  
  DOH-URA Katsumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Tohoku University

All 2013 2012 2009 2008 2007

All Journal Article Presentation

[Journal Article] Amyloidophilic compounds for prion diseases2009
- Author(s)
  Teruya K, Kawagoe K, Kimura T, Chen CJ, Sakasegawa Y, Doh-ura K
- Journal Title
  
  Infect Disord Drug Targets 9(1)
  
  Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390234
[Journal Article] Amyloidophilic compounds for prion diseases2009
- Author(s)
  Teruya K, Kawagoe K, Kimura T, Chen CJ, Sakasegawa Y, Doh-ura K
- Journal Title
  
  Infect Disord Drug Targets. 9(1)
  
  Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390234
[Journal Article] プリオン病の分子標的治療2007
- Author(s)
  逆瀬川裕二, 堂浦克美
- Journal Title
  
  神経研究の進歩 59(4)
  
  Pages: 405-414
- Data Source
  KAKENHI-PROJECT-19390234
[Journal Article] プリオン病の分子標的治療。2007
- Author(s)
  逆瀬川裕二, 堂浦克美
- Journal Title
  
  神経研究の進歩 59(4)
  
  Pages: 405-414
- Data Source
  KAKENHI-PROJECT-19390234
[Journal Article] プリオン病の診断支援・治療へ試み。2007
- Author(s)
  逆瀬川裕二, 堂浦克美
- Journal Title
  
  日本臨床 65(8)
  
  Pages: 1417-1422
- Data Source
  KAKENHI-PROJECT-19390234
[Journal Article] Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner2007
- Author(s)
  Kawasaki Y, Kawagoe K, Chen CJ, Teruya K, Sakasegawa Y, Doh-Ura K
- Journal Title
  
  J. Virol 81(23)
  
  Pages: 12889-12898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390234
[Journal Article] プリオン病の診断支援・治療への試み2007
- Author(s)
  逆瀬川裕二, 堂浦克美
- Journal Title
  
  日本臨床 65(8)
  
  Pages: 1417-1422
- Data Source
  KAKENHI-PROJECT-19390234
[Journal Article] Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner.2007
- Author(s)
  Kawasaki Y, Kawagoe K, Chen CJ, Teruya K, Sakasegawa Y, Doh-Ura K
- Journal Title
  
  J. Virol. 81(23)
  
  Pages: 12889-12898
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390234
[Presentation] Cell biological and biochemical approaches of prion biology2013
- Author(s)
  Yuji Sakasegawa, Tomohiro Kimura, Katsumi Doh-ura
- Organizer
  第86回日本生化学会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-24659422
[Presentation] Glycerol enhances the PrPres production via a PI3K signaling pathway in prion-infected neuroblastoma cells）2013
- Author(s)
  Eiji Sakai, Yuji Sakasegawa, Katsumi Doh-ura
- Organizer
  APPS2013
- Place of Presentation
  長崎県佐世保市
- Data Source
  KAKENHI-PROJECT-24659422
[Presentation] Extracellular heatshock protein 90 enhances PrPres production in prion-infected neuroblastoma N2a cells.2012
- Author(s)
  Yuji Sakasegawa, Katsumi Doh-ura
- Organizer
  Asian Pacific Prion symposium 2012
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-24659422
[Presentation] Glycerol enhances the protease-resistance prion protein production in prion-infected neuroblastoma cells.2012
- Author(s)
  Eiji Sakai, Yuji Sakasegawa, Katsumi Doh-ura
- Organizer
  Asian Pacific Prion symposium 2012
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-24659422
[Presentation] Heat shock protein 90(Hsp90)stimulates polymerization of a copper-loaded prion protein2008
- Author(s)
  Sakasegawa Y, Hachiya NS, Kaneko K, Doh-ura K
- Organizer
  Prion2008
- Place of Presentation
  Madrid
- Data Source
  KAKENHI-PROJECT-19390234
[Presentation] 持続性プリオン感染細胞におけるPrPresの産生を抑制する新規ヒートショック蛋白質90阻害剤2008
- Author(s)
  逆瀬川裕二, 堂浦克美
- Organizer
  2008年プリオン研究会
- Place of Presentation
  新得(北海道)
- Data Source
  KAKENHI-PROJECT-19390234
[Presentation] Heat shock protein 90 (Hsp90) stimulates polymerization of a copper-loaded prion protein.2008
- Author(s)
  Sakasegawa Y, Hachiya NS, Kaneko K, Doh-ura K
- Organizer
  Prion2008
- Place of Presentation
  Madrid (Spain)
- Data Source
  KAKENHI-PROJECT-19390234
[Presentation] Binding of mouse prion protein to heparin2008
- Author(s)
  Teruya K, Wakao T, Nishimura T, Kimura Y, Sakasegawa Y, Suda Y, Doh-ura K
- Organizer
  Meeting of 17th Methods in Protein Structure Analysis(MPSA2008)
- Place of Presentation
  Sapporo, August(26-29)
- Data Source
  KAKENHI-PROJECT-19390234
[Presentation] Binding of mouse prion protein to heparin2008
- Author(s)
  Teruya K, Wakao T, Nishimura T, Kimura Y, Sakasegawa Y, Suda Y, Doh-ura K
- Organizer
  Meeting of 17th Methods in Protein Structure Analysis (MPSA2008)
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-19390234
[Presentation] The C-terminal chaperone domain of heat shock protein 90 kDa is responsible for the conformational modification of copper-loaded recombinant prion protein2007
- Author(s)
  Sakasegawa Y, Hachiya NS, Kaneko K, Doh-ura K
- Organizer
  2007年プリオン研究会
- Place of Presentation
  津南(新潟)
- Data Source
  KAKENHI-PROJECT-19390234
[Presentation] HSP90 family proteins modify the comformation of copper-loaded prion protein in a nucleotide-dependent manner2007
- Author(s)
  Sakasegawa Y, Hachiya NS, Kaneko K, Doh-ura K
- Organizer
  Prion2007
- Place of Presentation
  Edinburgh
- Data Source
  KAKENHI-PROJECT-19390234
[Presentation] The C-terminal chaperone domain of heat shock protein 90 kDa is responsible for the conformational modification of copper-loaded recombinant prion protein.2007
- Author(s)
  Sakasegawa Y, Hachiya NS, Kaneko K, Doh-ura K
- Organizer
  2007年プリオン研究会
- Place of Presentation
  津南(新潟)
- Data Source
  KAKENHI-PROJECT-19390234
[Presentation] HSP90 family proteins modify the comformation of copper-loaded prion protein in a nucleotide-dependent manner.2007
- Author(s)
  Sakasegawa Y, Hachiya NS, Kaneko K, Doh-ura K
- Organizer
  Prion2007
- Place of Presentation
  Edinburgh
- Data Source
  KAKENHI-PROJECT-19390234

1. TERUYA Kenta (30372288)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. DOH-URA Katsumi (00263012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results

SAKASEGAWA Yuji 逆瀬川 裕二

Research Projects

Research Products

Co-Researchers

Reconstitution of the cellular prion protein unfolding system using Hsp90 and its associated proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research of therapeutic strategy applying to both prion diseases and Alzheimer's disease

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Amyloidophilic compounds for prion diseases2009

Author(s)

Journal Title

Data Source

[Journal Article] Amyloidophilic compounds for prion diseases2009

Author(s)

Journal Title

Data Source

[Journal Article] プリオン病の分子標的治療2007

Author(s)

Journal Title

Data Source

[Journal Article] プリオン病の分子標的治療。2007

Author(s)

Journal Title

Data Source

[Journal Article] プリオン病の診断支援・治療へ試み。2007

Author(s)

Journal Title

Data Source

[Journal Article] Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner2007

Author(s)

Journal Title

Data Source

[Journal Article] プリオン病の診断支援・治療への試み2007

Author(s)

Journal Title

Data Source

[Journal Article] Orally administered amyloidophilic compound is effective in prolonging the incubation periods of animals cerebrally infected with prion diseases in a prion strain-dependent manner.2007

Author(s)

Journal Title

Data Source

[Presentation] Cell biological and biochemical approaches of prion biology2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Glycerol enhances the PrPres production via a PI3K signaling pathway in prion-infected neuroblastoma cells）2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Extracellular heatshock protein 90 enhances PrPres production in prion-infected neuroblastoma N2a cells.2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Glycerol enhances the protease-resistance prion protein production in prion-infected neuroblastoma cells.2012

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Heat shock protein 90(Hsp90)stimulates polymerization of a copper-loaded prion protein2008

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 持続性プリオン感染細胞におけるPrPresの産生を抑制する新規ヒートショック蛋白質90阻害剤2008

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Heat shock protein 90 (Hsp90) stimulates polymerization of a copper-loaded prion protein.2008

Author(s)

SAKASEGAWA Yuji 逆瀬川裕二