Sheng Zijing 盛子敬

… Alternative Names

SHENG Zijing 盛子敬

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Researcher Number	90467895
Affiliation (Current)	2025: 九州大学, 医学研究院, 共同研究員
Affiliation (based on the past Project Information) *help	2016: 九州大学, 生体防御医学研究所, 特別研究員 2015: 九州大学, 生体防御医学研究所, 研究員 2014: 九州大学, ヌクレオチドプール研究センター, 助教 2012 – 2014: 九州大学, 学内共同利用施設等, 助教 2011: 九州大学, ヌクレオチドプール研究センター, 助教 2010: 九州大学, 生体防御医学研究所, 学術研究員 2010: 九州大学, 生体防御医学研究所, 特任助教
Review Section/Research Field	Principal Investigator Experimental pathology Except Principal Investigator Risk sciences of radiation/Chemicals
Keywords	Principal Investigator MTH1,OGG1,MUTYH / MUTYH / OGG1 / MTH1 / パーキンソン病 / 8-oxoG Except Principal Investigator DNA修復 / 脱アミノ化ヌクレオチド / 酸化ヌクレオチド / 病態モデル … More / 化学物質 / 環境ストレス / ヌクレオチドプール / 放射線 / 環境スレス / アルツハイマー病 / 自然突然変異 / 細胞増殖阻害 / 酸化的損傷 / 神経変性 / 細胞死 / バイスタンダー効果 / 突然変異 / RNA / DNA / 活性酸素 Less

Molecular mechanism of degeneration of dopaminergic neurons caused by 8-oxoguaninePrincipal Investigator
- Principal Investigator
  
  Sheng Zijing
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyushu University
Molecular pathology and regulatory mechanisms involved in the breakdown of nucleotide pool homeostasis under environmental stress
- Principal Investigator
  
  NAKABEPPU YUSAKU
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyushu University
環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態と制御機構の解明
- Principal Investigator
  
  中別府雄作
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Kyushu University

All 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain.2017
- Author(s)
  Abolhassani N, Leon J, Sheng Z, Oka S, Hamasaki H, Iwaki T, Nakabeppu Y.
- Journal Title
  
  Mech Ageing Dev.
  
  Volume: 161 Pages: 95-104
- DOI
  10.1016/j.mad.2016.05.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26290017, KAKENHI-PROJECT-26460490, KAKENHI-PROJECT-15K15085, KAKENHI-PROJECT-17H01391
[Journal Article] 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions2016
- Author(s)
  Julio, Leon, Sakumi Kunihiko, Castillo Erika, Sheng Zijing, Oka Sugako, Nakabeppu Yusaku.
- Journal Title
  
  Scientific Reports
  
  Volume: 25 Issue: 1 Pages: 22086-22086
- DOI
  10.1038/srep22086
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460490, KAKENHI-PROJECT-15K15085, KAKENHI-PROJECT-15H04298, KAKENHI-PROJECT-25461281
[Journal Article] 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair.2012
- Author(s)
  Sheng, Z., et. al.
- Journal Title
  
  The Journal of clinical investigation
  
  Volume: 122 Issue: 12 Pages: 4344-4361
- DOI
  10.1172/jci65053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00463, KAKENHI-PROJECT-22221004
[Journal Article] Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase.2010
- Author(s)
  Nakabeppu, Y., S.Oka, Z.Sheng, D.Tsuchimoto, K.Sakumi.
- Journal Title
  
  Mutat Res
  
  Volume: 703 Pages: 51-58
- NAID
  120005227112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] アルツハイマー病進展における核あるいはミトコンドリアDNA中に蓄積した8-oxoguanineの役割2016
- Author(s)
  岡　素雅子, 盛　子敬, フリオ　レオン, 土本大介, 作見　邦彦, 中別府　雄作
- Organizer
  第３９回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] MUTYH-dependent programmed cell death triggered by 8-oxoguanine and its implication in tumor suppression and neurodegeneration2015
- Author(s)
  Yusaku Nakabeppu, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
- Organizer
  15th International Congress of Radition Research
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2015-05-25
- Invited
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] Cranial irradiation causes hippocampal degeneration through accumulation of 8-oxoguanine in mitochondrial DNA in neurons2015
- Author(s)
  Sheng Zijing, Nakabeppu Yusaku.
- Organizer
  日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2015-07-28
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] 活性酸素によるDNA損傷が引起こすさまざまな生命現象：突然変異から神経変性まで2015
- Author(s)
  中別府雄作, 岡素雅子, 盛子敬, 大野みずき, 土本大介, 作見邦彦
- Organizer
  第17回日本進化学会年大会
- Place of Presentation
  東京
- Year and Date
  2015-08-20
- Invited
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] 8-oxo-dGTP generated in nucleotide pools is a major cause of neurodegeneration under oxidative stress.2014
- Author(s)
  Sheng Zijing, Sugako Oka, Yasuhiro Ikeda, Margherita Bignami, Yusaku Nakabeppu
- Organizer
  International symposium "New Frontier of Molecular Neuropathology 2014"
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Striatal degeneration initiated by a mitochondrial toxin, 3-nitropropionic acid is dependent on MUTYH-initiated base excision repair of 8-oxoguanine-paired adenine.2013
- Author(s)
  Yusaku Nakabeppu, Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi
- Organizer
  11th International Conference on Alzheimer's & Parkinson's Diseases
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair2013
- Author(s)
  38. Zing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  Gordon research conference on Oxidative Stress & Disease
- Place of Presentation
  Les Diablerets, Switzerland
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH-dependent neurodegeneration initiated by mitochondrial accumulation of 8-oxoguanine in neurons is efficiently suppressed by MTH1 and OGG12013
- Author(s)
  Zijing Sheng, Sugako Oka, Yusaku Nakabeppu
- Organizer
  10th Conference of the Asian Society of Mitochondrial Research and Medicine (ASMRM)
- Place of Presentation
  Seoul, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Oxidative damage in brain genomes and neuroprotective mechanisms.2013
- Author(s)
  Yusaku Nakabeppu, Zijing Sheng, Sugako Oka
- Organizer
  第90回日本生理学会大会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Expression of the defense enzymes MTH1, OGG1 and MUTYH against oxidative damage in nucleic acids in the mouse brain2013
- Author(s)
  Zijing Sheng, Yusaku Nakabeppu
- Organizer
  Neuro2013 Joint Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair.2013
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi & Yusaku Nakabeppu
- Organizer
  Gordon Research Conference on Oxidative Stress & Disease
- Place of Presentation
  Les Diablerets, Switzerland
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 核酸損傷と生体防御2013
- Author(s)
  中別府雄作, 岡素雅子, 盛子敬, 土本大介, 作見邦彦
- Organizer
  第24回日本生体防御学会学術集会
- Place of Presentation
  熊本
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化ストレスは MUTYH による塩基除去修復経路を介してcalpain/PARP 依存性の神経変性を引き起こす.2012
- Author(s)
  盛子敬，岡素雅子，土本大介，作見邦彦，中別府雄作
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性酸素による核酸の修飾とゲノム応答の遺伝学.2012
- Author(s)
  中別府雄作，土本大介，盛子敬，岡素雅子，作見邦彦
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  福岡
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Base excision repair by MUTYH initiates calpain/PARP-dependent neurodegeneration under oxidative stress.2012
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  第35回日本神経科学大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair.2012
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi and Yusaku Nakabeppu
- Organizer
  The 9th ASMRM and Chinese Mit'2012
- Place of Presentation
  Beijing, China
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 8-Oxoguanine causes complex neurodegeneration in a MUTYH-dependent manner, which can be efficiently suppressed by MTH1 and/or OGG1.2012
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi and Yusaku Nakabeppu
- Organizer
  The 8th 3R Symposium (International Symposium on DNA Replication, Recombination and Repair)
- Place of Presentation
  Yumebutai, Awaji, Hyogo
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 活性分子種による核酸の化学修飾と生体応答2011
- Author(s)
  中別府雄作, 猪山輝昭, 岡素雅子, 盛子敬, 作見邦彦, 土本大介
- Organizer
  第2回 Molecular Cardiovascular Conference
- Place of Presentation
  余市(招待講演)
- Year and Date
  2011-09-04
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] マウス黒質における核酸の酸化損傷防御酵素群, MTH1,OGG1,MUTYHの領域特異的な発現2011
- Author(s)
  盛子敬, 中別府雄作
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 酸化ストレスはDNA修復酵素MUTYHに依存して神経変性を引き起こす2011
- Author(s)
  盛子敬, 岡素雅子, 土本大介, 作見邦彦, 中別府雄作
- Organizer
  第4回Kyushu CVD Conference
- Place of Presentation
  福岡(招待講演)
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Base excision repair-mediated programmed cell death and neurodegeneration2010
- Author(s)
  Zijing Sheng, Sugako Oka, Yusaku Nakabeppu
- Organizer
  3rd International Genome Dynamics in Neurosciences Conference "DNA Repair and Neurological disease"
- Place of Presentation
  Brighton, UK
- Year and Date
  2010-07-19
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態2010
- Author(s)
  中別府雄作, 猪山輝昭, Nona Abolhassani, 太田詠子, 盛子敬, 岡素雅子, 作見邦彦, 土本大介
- Organizer
  日本遺伝学会第82回大会
- Place of Presentation
  札幌
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Quality control in the purine nucleotide pools is essential for maintaining genomic integrity in mammals.2010
- Author(s)
  Yusaku Nakabeppu, Nona Abolhassani, Teruaki Iyama, Zijing Sheng, Sugako Oka, Kunihiko Sakumi, Daisuke Tsuchimoto
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] MUTYH-initiated base excision repair triggers two distinct cell death pathways by monitoring 8-oxoguanine in nuclear and mitochondrial DNAs.2010
- Author(s)
  Sugako Oka, Zijing Sheng, Yusaku Nakabeppu
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mitochondrial toxin, 3-nitropropionic acid induces striatal degeneration through the two distinct MUTYH-dependent cell death pathways.2010
- Author(s)
  Zijing Sheng, Sugako Oka, Daisuke Tsuchimoto, Kunihiko Sakumi, Yusaku Nakabeppu
- Organizer
  The 7th 3R (Replication, Recombination and Repair) Symposium
- Place of Presentation
  Toyama, Japan
- Year and Date
  2010-10-26
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] 環境ストレスによるヌクレオチドプールの恒常性破綻に起因するゲノム障害とその防御機構2010
- Author(s)
  中別府雄作, Nona Abolhassani, 猪山輝昭, 太田詠子, 盛子敬, 岡素雅子, 土本大介, 作見邦彦
- Organizer
  B20B2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Control mechanisms of genetic diversity and programed cell death induced by 8-oxoguanine in mammals
- Author(s)
  Yusaku Nakabeppu, Mizuki Ohno, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
- Organizer
  9th ３R (Replication, Repair, recombination) symposium
- Place of Presentation
  御殿場
- Year and Date
  2014-11-17 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] MUTYHによって開始される塩基除去修復に依存した２つの独立したプログラム細胞死の経路
- Author(s)
  岡素雅子, 盛子敬, 中別府雄作
- Organizer
  日本遺伝学会　第86回大会
- Place of Presentation
  長浜
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] MUTYH-dependent programed cell death induced by 8-oxoguanine accumulated in cellular DNAs and its implication in tumorigenesis and neruodegeneration
- Author(s)
  Yusaku Nakabeppu, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
- Organizer
  5th US-Japan DNA Repair Meeting
- Place of Presentation
  鳴門市
- Year and Date
  2014-10-28 – 2014-10-31
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] Mechanism by which 8-oxoguanine causes dopaminergic neurodegeneration in aged mice
- Author(s)
  Zijing, Sheng, Yusaku Nakabeppu
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Control mechanisms of genetic diversity and programed cell death induced by 8-oxoguanine in mammals
- Author(s)
  Yusaku Nakabeppu, Mizuki Ohno, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
- Organizer
  9th ３R (Replication, Repair, recombination) symposium
- Place of Presentation
  御殿場
- Year and Date
  2014-11-11 – 2014-11-16
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] ほ乳動物ゲノムにおける8-オキソグアニンの修復プロセッシングと細胞運命
- Author(s)
  岡素雅子, 盛子敬, 作見邦彦, 中別府雄作
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] MUTYH-dependent programed cell death induced by 8-oxoguanine accumulated in cellular DNAs and its implication in tumorigenesis and neruodegeneration
- Author(s)
  Yusaku Nakabeppu, Sugako Oka, Zijing Sheng, Kunihiko Sakumi
- Organizer
  5th US-Japan DNA Repair Meeting
- Place of Presentation
  鳴門
- Year and Date
  2014-10-28 – 2014-10-31
- Invited
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] Mechanism by which 8-oxoguanine causes dopaminergic neurodegeneration in aged mice
- Author(s)
  Zijing Sheng, Yusaku Nakabeppu
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26460490
[Presentation] MUTYHによって開始される塩基除去修復に依存した２つの独立したプログラム細胞死の経路
- Author(s)
  岡素雅子, 盛子敬, 中別府雄作
- Organizer
  日本遺伝学会第86回大会
- Place of Presentation
  長浜
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-22221004
[Presentation] ほ乳動物ゲノムにおける8-オキソグアニンの修復プロセッシングと細胞運命
- Author(s)
  岡素雅子, 盛子敬, 作見邦彦, 中別府雄作
- Organizer
  第37回日本分子生物学会ワークショップ
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-22221004

1. NAKABEPPU YUSAKU (30180350)

# of Collaborated Projects: 3 results

# of Collaborated Products: 38 results
2. SAKUMI Kunihiko (50211933)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
3. TSUCHIMOTO Daisuke (70363348)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
4. OKA Sugako (80467894)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
5. AKIMOTO Yoriko (50613254)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. OHYAGI Yasumasa (30301336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 岩城徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sheng Zijing 盛 子敬

SHENG Zijing 盛 子敬

Research Projects

Research Products

Co-Researchers

Molecular mechanism of degeneration of dopaminergic neurons caused by 8-oxoguaninePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular pathology and regulatory mechanisms involved in the breakdown of nucleotide pool homeostasis under environmental stress

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態と制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Programmed cell death triggered by nucleotide pool damage and its prevention by MutT homolog-1 (MTH1) with oxidized purine nucleoside triphosphatase.2010

Author(s)

Journal Title

NAID

Data Source

[Presentation] アルツハイマー病進展における核あるいはミトコンドリアDNA中に蓄積した8-oxoguanineの役割2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] MUTYH-dependent programmed cell death triggered by 8-oxoguanine and its implication in tumor suppression and neurodegeneration2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Cranial irradiation causes hippocampal degeneration through accumulation of 8-oxoguanine in mitochondrial DNA in neurons2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 活性酸素によるDNA損傷が引起こすさまざまな生命現象： 突然変異から神経変性まで2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 8-oxo-dGTP generated in nucleotide pools is a major cause of neurodegeneration under oxidative stress.2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Striatal degeneration initiated by a mitochondrial toxin, 3-nitropropionic acid is dependent on MUTYH-initiated base excision repair of 8-oxoguanine-paired adenine.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 8-Oxoguanine in brain causes complex neurodegeneration through DNA repair2013

Author(s)

Organizer

Sheng Zijing 盛子敬

SHENG Zijing 盛子敬

[Presentation] 活性酸素によるDNA損傷が引起こすさまざまな生命現象：突然変異から神経変性まで2015

[Presentation] 酸化ストレスは MUTYH による塩基除去修復経路を介してcalpain/PARP 依存性の神経変性を引き起こす.2012