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Kubo Terufumi  久保 輝文

… Alternative Names

KUBO Terufumi  久保 輝文

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Researcher Number 90580019
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-9274-2551
Affiliation (Current) 2025: 札幌医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2024: 札幌医科大学, 医学部, 助教
2018 – 2022: 札幌医科大学, 医学部, 助教
2017: 札幌医科大学, 医学部, 特任助教
2016: 札幌医科大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 56050:Otorhinolaryngology-related / Basic Section 49020:Human pathology-related / Respiratory organ internal medicine
Except Principal Investigator
Medium-sized Section 49:Pathology, infection/immunology, and related fields / Human pathology
Keywords
Principal Investigator
p63/p73 / p63 / ΔNp63 / サイトカイン / 気管支喘息 / 2型炎症 / アレルギー性鼻炎 / 気道上皮細胞 / 免疫バリア / 三次元培養 … More / 物理バリア / 上皮細胞 / IL-13 / 分化 / ケラチノサイト / p53ファミリー転写因子 / 上皮バリア機能 / アトピー性皮膚炎 / 免疫学 / 病理学 / アレルギー・ぜんそく / アポトーシス / 気管支上皮 / プロテアーゼ阻害因子 / プロテアーゼ / deltaNp63 / 気管支上皮細胞 … More
Except Principal Investigator
がん抗原 / バイオマーカー / がん免疫療法 / T細胞抗原受容体 / Antigen peptide / HLA class I / メラノーマ / 腫瘍浸潤T細胞 / シングルセル解析 / HLA multimer / 抗原エピトープ / pHLA multimer / HLA複合体 / 細胞・組織 / 分子生物学 / 免疫学 / 腫瘍学 / 病理学 / Tumor antigen / 免疫病理診断 / 腫瘍免疫 / Immunohistochemistry / Immune response / Tumor immune escape / Single cell analysis / Cancer stem cell / Tumor microenvironment / 免疫病理バイオマーカー / 単細胞遺伝子発現解析 / がん免疫応答 / がん組織微小環境 / 腫瘍組織微小環境 / 免疫チェックポイント阻害剤 / シングルセル遺伝子解析 / がん幹細胞 / 単細胞遺伝子解析 / がん最適化治療 / 免疫組織染色 / 腫瘍微小環境 Less
  • Research Projects

    (5 results)
  • Research Products

    (40 results)
  • Co-Researchers

    (14 People)
  •  Deciphering the mechanism of type 2 inflammation environment formation initiated by p63/p73 expressed in airway epithelial cellsPrincipal Investigator

    • Principal Investigator
      久保 輝文
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Sapporo Medical University
  •  Comprehensive analysis of T-cell receptor ligand by using pHLA multimer library

    • Principal Investigator
      鳥越 俊彦
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      Sapporo Medical University
  •  Comprehensive understanding of p63/p73-dependent deviated state keratinocytes in atopic dermatitis.Principal Investigator

    • Principal Investigator
      KUBO Terufumi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49020:Human pathology-related
    • Research Institution
      Sapporo Medical University
  •  Basic research on the immunohistological categorization of tumor microenvironment

    • Principal Investigator
      TORIGOE Toshihiko
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Human pathology
    • Research Institution
      Sapporo Medical University
  •  Mechanism of the ILC2 activation in bronchial asthma regulated by deltaNp63-related epimmunomePrincipal Investigator

    • Principal Investigator
      KUBO Terufumi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Sapporo Medical University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

  • [Journal Article] Cisplatin-induced HSF1-HSP90 axis enhances the expression of functional PD-L1 in oral squamous cell carcinoma2023

    • Author(s)
      Sasaya T, Kubo T, Murata K, Mizue Y, Sasaki K, Yanagawa J, Imagawa M, Kato H, Tsukahara T, Kanaseki T, Tamura Y, Miyazaki A, Hirohashi Y, Torigoe T.
    • Journal Title

      Cancer Med

      Volume: 12 Issue: 4 Pages: 4605-4615

    • DOI

      10.1002/cam4.5310

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-19K10292, KAKENHI-PROJECT-21K18257
  • [Journal Article] Development of CAR-T cells specifically targeting cancer stem cell antigen DNAJB8 against solid tumours.2023

    • Author(s)
      127.Watanabe Y, Tsukahara T, Murata K, Hamada S, Kubo T, Kanaseki T, Hirohashi Y, Emori M, Teramoto A, Nakatsugawa M, Yamashita T, Torigoe T
    • Journal Title

      Br J Cancer.

      Volume: 128 Issue: 5 Pages: 886-895

    • DOI

      10.1038/s41416-022-02100-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
  • [Journal Article] Characterization of Proteasome-Generated Spliced Peptides Detected by Mass Spectrometry2022

    • Author(s)
      Kato Koji、Nakatsugawa Munehide、Tokita Serina、Hirohashi Yoshihiko、Kubo Terufumi、Tsukahara Tomohide、Murata Kenji、Chiba Hirofumi、Takahashi Hiroki、Hirano Naoto、Kanaseki Takayuki、Torigoe Toshihiko
    • Journal Title

      The Journal of Immunology

      Volume: 208 Issue: 12 Pages: 2856-2865

    • DOI

      10.4049/jimmunol.2100717

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21528, KAKENHI-PROJECT-21K18257
  • [Journal Article] Spindle cell tumor with histiocytic and myogenic marker expression in the lymph node of a human T-cell leukemia virus type 1 carrier.2022

    • Author(s)
      Kubo T, Hirayama Y, Sakihama S, Kikuchi T, Hirohashi Y, Tsujiwaki M, Karube K, Hasegawa T, Torigoe T.
    • Journal Title

      Pathol Res Pract.

      Volume: 234 Pages: 153935-153935

    • DOI

      10.1016/j.prp.2022.153935

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K18257
  • [Journal Article] アトピー・アレルギー疾患における 2 型炎症環境の 形成機構と上皮細胞の免疫および物理バリアとしての役割2022

    • Author(s)
      小林 拓海、田中 千景、久保 輝文、鳥越 俊彦
    • Journal Title

      札幌医学雑誌

      Volume: 90 Pages: 43-49

    • Data Source
      KAKENHI-PROJECT-19K16562
  • [Journal Article] High aldehyde dehydrogenase 1 activity is related to radiation resistance due to activation of AKT signaling after insulin stimulation in prostate cancer2022

    • Author(s)
      Wakamiya Takahito、Hirohashi Yoshihiko、Murai Aiko、Yanagawa Junko、Mizue Yuka、Kubo Terufumi、Hashimoto Shinichi、Murata Kenji、Kanaseki Takayuki、Tsukahara Tomohide、Nishida Sachiyo、Kohjimoto Yasuo、Hara Isao、Torigoe Toshihiko
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 590 Pages: 117-124

    • DOI

      10.1016/j.bbrc.2021.12.095

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K18257
  • [Journal Article] Usefulness of Immunostaining Scoring for Predicting Response to Single-Agent Nivolumab in Patients with Metastatic Renal Cell Carcinoma2022

    • Author(s)
      若宮 崇人、久保 輝文、山下 真平、柑本 康夫、鳥越 俊彦、原 勲
    • Journal Title

      泌尿器科紀要

      Volume: 68 Issue: 10 Pages: 311-315

    • DOI

      10.14989/ActaUrolJap_68_10_311

    • ISSN
      0018-1994
    • Year and Date
      2022-10-31
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K18257
  • [Journal Article] GRIK2 is a target for bladder cancer stem-like cell-targeting immunotherapy2022

    • Author(s)
      Miyata H, Hirohashi Y, Yamada S, Yanagawa J, Murai A, Hashimoto S, Tokita S, Hori K, Abe T, Kubo T, Tsukahara T, Kanaseki T, Shinohara N, Torigoe T.
    • Journal Title

      Cancer Immunology Immunotherapy

      Volume: 71 Issue: 4 Pages: 795-806

    • DOI

      10.1007/s00262-021-03025-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-21K18257
  • [Journal Article] Cancer immunohistogram representing cancer-immunity cycle by immunohistochemistry predicts the efficacy of immune checkpoint inhibitors in urological cancer patients2022

    • Author(s)
      Kijima Toshiki、Kubo Terufumi、Nishihara Daisaku、Nukui Akinori、Hirohashi Yoshihiko、Torigoe Toshihiko、Kamai Takao
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 10617-10617

    • DOI

      10.1038/s41598-022-14700-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09534, KAKENHI-PROJECT-21K18257
  • [Journal Article] Tumor-infiltrating CD8 + T cells recognize a heterogeneously expressed functional neoantigen in clear cell renal cell carcinoma2022

    • Author(s)
      Matsuki M, Hirohashi Y, Nakatsugawa M, Murai A, Kubo T, Hashimoto S, Tokita S, Murata K, Kanaseki T, Tsukahara T, Nishida S, Tanaka T, Kitamura H, Masumori N, Torigoe T.
    • Journal Title

      Cancer Immunology Immunotherapy

      Volume: 71 Issue: 4 Pages: 905-918

    • DOI

      10.1007/s00262-021-03048-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-21K18257
  • [Journal Article] Immunopathological basis of immune-related adverse events induced by immune checkpoint blockade therapy2021

    • Author(s)
      Kubo Terufumi、Hirohashi Yoshihiko、Tsukahara Tomohide、Kanaseki Takayuki、Murata Kenji、Morita Rena、Torigoe Toshihiko
    • Journal Title

      Immunological Medicine

      Volume: 44 Issue: 2 Pages: 1-11

    • DOI

      10.1080/25785826.2021.1976942

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K18257
  • [Journal Article] Possible Pseudo-progression of Non-small Cell Lung Carcinoma in a Patient With Clinical Hyper-progression Associated With Trousseau Syndrome Who Was Treated With Pembrolizumab.2021

    • Author(s)
      Shionoya Y, Hirohashi Y, Takahashi H, Hashimoto M, Nishiyama K, Takakuwa Y, Nakatsugawa M, Kubo T, Kanaseki T, Tsukahara T, Torigoe T.
    • Journal Title

      Anticancer Res.

      Volume: 41 Issue: 7 Pages: 3699-3706

    • DOI

      10.21873/anticanres.15161

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
  • [Journal Article] Fundamental and Essential Knowledge for Pathologists Engaged in the Research and Practice of Immune Checkpoint Inhibitor-Based Cancer Immunotherapy2021

    • Author(s)
      Kubo Terufumi、Shinkawa Tomoyo、Kikuchi Yasuhiro、Murata Kenji、Kanaseki Takayuki、Tsukahara Tomohide、Hirohashi Yoshihiko、Torigoe Toshihiko
    • Journal Title

      Frontiers in Oncology

      Volume: 11 Pages: 1-14

    • DOI

      10.3389/fonc.2021.679095

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K18257
  • [Journal Article] Epithelioid granulomatous lesions express abundant programmed death ligand-1 (PD-L1): a discussion of adverse events in anti-PD-1 antibody-based cancer immunotherapy.2021

    • Author(s)
      Kubo T, Hirohashi Y, Tsukahara T, Kanaseki T, Murata K, Hasegawa T, Torigoe T.
    • Journal Title

      Hum Vaccin Immunother.

      Volume: 18 Issue: 7 Pages: 1-3

    • DOI

      10.1080/21645515.2020.1870364

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19458, KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
  • [Journal Article] Neuregulin-1-β1 and γ-secretase play a critical role in sphere-formation and cell survival of urothelial carcinoma cancer stem-like cells2021

    • Author(s)
      Matsuki M, Inoue R, Murai A, Kubo T, Hashimoto S, Murata K, Kanaseki T, Tsukahara T, Nishida S, Tanaka T, Kitamura H, Masumori N, Hirohashi Y, Torigoe T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 552 Pages: 128-135

    • DOI

      10.1016/j.bbrc.2021.03.038

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
  • [Journal Article] IL‐13 modulates ΔNp63 levels causing altered expression of barrier‐ and inflammation‐related molecules in human keratinocytes: A possible explanation for chronicity of atopic dermatitis2021

    • Author(s)
      Terufumi Kubo, Sayuri Sato, Tokimasa Hida, Tomoyuki Minowa, Yoshihiko Hirohashi, Tomohide Tsukahara, Takayuki Kanaseki, Kenji Murata, Hisashi Uhara ,Toshihiko Torigoe
    • Journal Title

      Immunity, Inflammation and Disease

      Volume: - Issue: 3 Pages: 734-745

    • DOI

      10.1002/iid3.427

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K16562, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
  • [Journal Article] Identification of characteristic subepithelial surface granulomatosis in immune‐related adverse event‐associated enterocolitis2021

    • Author(s)
      Kubo Terufumi、Hirohashi Yoshihiko、Keira Yoshiko、Akimoto Mayuko、Ikeda Tatsuru、Kikuchi Noriaki、Iwaki Hiroyuki、Kikuchi Tomoki、Obata Masahiko、Morita Rena、Kasai Kiyoshi、Segawa Keiko、Tsukahara Tomohide、Kanaseki Takayuki、Murata Kenji、Kikuchi Yasuhiro、Shinkawa Tomoyo、Hasegawa Tadashi、Torigoe Toshihiko
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 3 Pages: 1320-1325

    • DOI

      10.1111/cas.14773

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19458, KAKENHI-PROJECT-20H03460, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-21K18257
  • [Journal Article] Peptide vaccinations elicited strong immune responses that were reboosted by anti-PD1 therapy in a patient with myxofibrosarcoma2020

    • Author(s)
      Tsukahara, T. Watanabe, K. Murata, K. Takahashi, A. Mizushima, E. Shibayama, Y. Kameshima, H. Hatae, R. Ohno, Y. Kawahara, R. Murai, A. Nakatsugawa, M. Kubo, T. Kanaseki, T. Hirohashi, Y. Terui, T. Asanuma, H. Hasegawa, T. Sato, N. Torigoe, T.
    • Journal Title

      Cancer immunology immunotherapy

      Volume: 69 Issue: 2 Pages: 189-197

    • DOI

      10.1007/s00262-019-02455-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01540, KAKENHI-PROJECT-20H03807, KAKENHI-PROJECT-18K19458
  • [Journal Article] Severe cytokine release syndrome resulting in purpura fulminans despite successful response to nivolumab therapy in a patient with pleomorphic carcinoma of the lung: a case report2019

    • Author(s)
      Honjo, O. Kubo, T. Sugaya, F. Nishizaka, T. Kato, K. Hirohashi, Y. Takahashi, H. Torigoe, T.
    • Journal Title

      J Immunother Cancer

      Volume: 7 Issue: 1 Pages: 97-97

    • DOI

      10.1186/s40425-019-0582-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Journal Article] Immunohistological analysis of pancreatic carcinoma after vaccination with survivin 2B peptide: Analysis of an autopsy series.2019

    • Author(s)
      Kubo T, Tsurita G, Hirohashi Y, Yasui H, Ota Y, Watanabe K, Murai A, Matsuo K, Asanuma H, Shima H, Wada S, Nakatsugawa M, Kanaseki T, Tsukahara T, Mizuguchi T, Hirata K, Takemasa I, Imai K, Sato N, Torigoe T.
    • Journal Title

      Cancer Sci.

      Volume: 110 Issue: 8 Pages: 2386-2395

    • DOI

      10.1111/cas.14099

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-17H01540
  • [Journal Article] Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA-A24-positive pancreatic adenocarcinoma.2019

    • Author(s)
      Shima H, Tsurita G, Wada S, Hirohashi Y, Yasui H, Hayashi H, Miyakoshi T, Watanabe K, Murai A, Asanuma H, Tokita S, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Nakae Y, Sugita O, Ito YM, Ota Y, Kimura Y, Kutomi G, Hirata K, Mizuguchi T, Imai K, Takemasa I, Sato N, Torigoe T.
    • Journal Title

      Cancer Sci.

      Volume: 110 Issue: 8 Pages: 2378-2385

    • DOI

      10.1111/cas.14106

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10672, KAKENHI-PROJECT-17H01540
  • [Journal Article] Osteosarcoma‐initiating cells show high aerobic glycolysis and attenuation of oxidative phosphorylation mediated by LIN28B2019

    • Author(s)
      Mizushima Emi、Tsukahara Tomohide、Emori Makoto、Murata Kenji、Akamatsu Asuka、Shibayama Yuji、Hamada Shuto、Watanabe Yuto、Kaya Mitsunori、Hirohashi Yoshihiko、Kanaseki Takayuki、Nakatsugawa Munehide、Kubo Terufumi、Yamashita Toshihiko、Sato Noriyuki、Torigoe Toshihiko
    • Journal Title

      Cancer Science

      Volume: 111 Issue: 1 Pages: 36-46

    • DOI

      10.1111/cas.14229

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10974, KAKENHI-PROJECT-17H01540, KAKENHI-PROJECT-20H03807
  • [Journal Article] Clonal analysis revealed functional heterogeneity in cancer stem-like cell phenotypes in uterine endometrioid adenocarcinoma.2019

    • Author(s)
      Tabuchi Y, Hirohashi Y, Hashimoto S, Mariya T, Asano T, Ikeo K, Kuroda T, Mizuuchi M, Murai A, Uno S, Kawai N, Kubo T, Nakatsugawa M, Kanaseki T, Tsukahara T, Saito T, Torigoe T.
    • Journal Title

      Exp Mol Pathol

      Volume: 106 Pages: 78-88

    • DOI

      10.1016/j.yexmp.2018.11.013

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11285, KAKENHI-PLANNED-17H06399, KAKENHI-PROJECT-16H05451, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H01540
  • [Journal Article] ABCG2 expression is related to low 5-ALA photodynamic diagnosis (PDD) efficacy and cancer stem cell phenotype, and suppression of ABCG2 improves the efficacy of PDD2019

    • Author(s)
      Kawai Noriko、Hirohashi Yoshihiko、Ebihara Yuma、Saito Takuma、Murai Aiko、Saito Takahiro、Shirosaki Tomohide、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Shichinohe Toshiaki、Li Liming、Hirano Satoshi、Torigoe Toshihiko
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 5 Pages: 0216503-0216503

    • DOI

      10.1371/journal.pone.0216503

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11285, KAKENHI-PROJECT-19K16822, KAKENHI-PROJECT-17H01540
  • [Journal Article] Cellular stress induces cancer stem-like cells through expression of DNAJB8 by activation of heat shock factor 12018

    • Author(s)
      Kusumoto Hiroki、Hirohashi Yoshihiko、Nishizawa Satoshi、Yamashita Masamichi、Yasuda Kazuyo、Murai Aiko、Takaya Akari、Mori Takashi、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Kondo Toru、Sato Noriyuki、Hara Isao、Torigoe Toshihiko
    • Journal Title

      Cancer Science

      Volume: 109 Issue: 3 Pages: 741-750

    • DOI

      10.1111/cas.13501

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-15K10606, KAKENHI-PROJECT-17H01540
  • [Journal Article] Differential bronchial epithelial response regulated by ΔNp63: a functional understanding of the epithelial shedding found in asthma2018

    • Author(s)
      Kubo Terufumi、Tsujiwaki Mitsuhiro、Hirohashi Yoshihiko、Tsukahara Tomohide、Kanaseki Takayuki、Nakatsugawa Munehide、Hasegawa Tadashi、Torigoe Toshihiko
    • Journal Title

      Laboratory Investigation

      Volume: 99 Issue: 2 Pages: 158-168

    • DOI

      10.1038/s41374-018-0132-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-16K21249, KAKENHI-PROJECT-17H01540
  • [Journal Article] Development of a T-cell receptor multimer with high avidity for detecting a naturally presented tumor-associated antigen on osteosarcoma cells2018

    • Author(s)
      Watanabe Kazue、Tsukahara Tomohide、Toji Shingo、Saitoh Shogo、Hirohashi Yoshihiko、Nakatsugawa Munehide、Kubo Terufumi、Kanaseki Takayuki、Kameshima Hidekazu、Terui Takeshi、Sato Noriyuki、Torigoe Toshihiko
    • Journal Title

      Cancer Science

      Volume: 110 Issue: 1 Pages: 40-51

    • DOI

      10.1111/cas.13854

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-17H01540
  • [Journal Article] Brother of the regulator of the imprinted site (BORIS) variant subfamily 6 is a novel target of lung cancer stem-like cell immunotherapy2017

    • Author(s)
      Horibe, R. Hirohashi, Y. Asano, T. Mariya, T. Suzuki, T. Takaya, A. Saijo, H. Shionoya, Y. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Watanabe, K. Atsuyama, E. Toji, S. Hirano, H. Hasegawa, T. Takahashi, H. Sato, N. Torigoe, T.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 3 Pages: 0171460-0171460

    • DOI

      10.1371/journal.pone.0171460

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Journal Article] Identification and functional analysis of variants of a cancer/testis antigen LEMD1 in colorectal cancer stem-like cells2017

    • Author(s)
      Takeda, R. Hirohashi, Y. Shen, M. Wang, L. Ogawa, T. Murai, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Nishidate, T. Okita, K. Kutomi, G. Sato, N. Takemasa, I. Torigoe, T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 485 Issue: 3 Pages: 651-657

    • DOI

      10.1016/j.bbrc.2017.02.081

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Journal Article] Implication of chemo-resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy.2017

    • Author(s)
      Shibayama Y, Tsukahara T, Emori M, Murata K, Mizushima E, Hirohashi Y, Kanaseki T, Nakatsugawa M, Kubo T, Yamashita T, Sato N, Torigoe T
    • Journal Title

      Cancer Science

      Volume: 108 Issue: 9 Pages: 1739-1745

    • DOI

      10.1111/cas.13319

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K10974, KAKENHI-PROJECT-17H01540
  • [Journal Article] Mismatch Repair Protein Deficiency Is a Risk Factor for Aberrant Expression of HLA Class I Molecules: A Putative "Adaptive Immune Escape" Phenomenon2017

    • Author(s)
      Kubo, T. Hirohashi, Y. Matsuo, K. Sonoda, T. Sakamoto, H. Furumura, K. Tsukahara, T. Kanaseki, T. Nakatsugawa, M. Hirano, H. Furuhata, T. Takemasa, I. Hasegawa, T. Torigoe, T.
    • Journal Title

      Anticancer Res

      Volume: 37 Issue: 3 Pages: 1289-1295

    • DOI

      10.21873/anticanres.11446

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Journal Article] Phosphorylation of HSF1 at serine 326 residue is related to the maintenance of gynecologic cancer stem cells through expression of HSP272017

    • Author(s)
      Yasuda, K. Hirohashi, Y. Mariya, T. Murai, A. Tabuchi, Y. Kuroda, T. Kusumoto, H. Takaya, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Tamura, Y. Hirano, H. Hasegawa, T. Saito, T. Sato, N. Torigoe, T.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 19 Pages: 31540-31553

    • DOI

      10.18632/oncotarget.16361

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Journal Article] LY6/PLAUR domain containing 3 has a role in the maintenance of colorectal cancer stem-like cells2017

    • Author(s)
      Wang, L. Hirohashi, Y. Ogawa, T. Shen, M. Takeda, R. Murai, A. Yamamoto, E. Kubo, T. Nakatsugawa, M. Kanaseki, T. Tsukahara, T. Nishidate, T. Okita, K. Kutomi, G. Sato, N. Takemasa, I. Torigoe, T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 486 Issue: 2 Pages: 232-238

    • DOI

      10.1016/j.bbrc.2017.02.112

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Journal Article] GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis2017

    • Author(s)
      Inoue Ryuta、Hirohashi Yoshihiko、Kitamura Hiroshi、Nishida Sachiyo、Murai Aiko、Takaya Akari、Yamamoto Eri、Matsuki Masahiro、Tanaka Toshiaki、Kubo Terufumi、Nakatsugawa Munehide、Kanaseki Takayuki、Tsukahara Tomohide、Sato Noriyuki、Masumori Naoya、Torigoe Toshihiko
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 17 Pages: 28826-28839

    • DOI

      10.18632/oncotarget.16259

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10599, KAKENHI-PROJECT-17H01540
  • [Presentation] 免疫チエックポイント阻害薬によるがん免疫療法の光と影2021

    • Author(s)
      久保 輝文
    • Organizer
      第49回日本臨床免疫学会総会
    • Data Source
      KAKENHI-PROJECT-19K16562
  • [Presentation] IL-13はケラチノサイトにおけるΔNp63の発現を調節し、バリアおよび炎症関連分子の発現の変化を引き起こす:アトピー性皮膚炎の慢性化メカニズムとの関連2021

    • Author(s)
      久保 輝文
    • Organizer
      第54回 北海道病理談話会
    • Data Source
      KAKENHI-PROJECT-19K16562
  • [Presentation] Proteogenomic approach for natural HLA class I ligand peptides of cancer cells.2019

    • Author(s)
      Torigoe T, Kanaseki T, Hirohashi Y, Tsukahara T, Nakatsugawa M, Kubo T, Shinkawa T.
    • Organizer
      EMBL Conference: Cancer Genomics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H01540
  • [Presentation] 腫瘍免疫の基礎2019

    • Author(s)
      久保 輝文
    • Organizer
      第108回日本病理学会総会
    • Data Source
      KAKENHI-PROJECT-19K16562
  • [Presentation] Differential bronchial epithelial response regulated by deltaNp63 : a potential mechanism explaining chronicity of asthma2017

    • Author(s)
      Terufumi Kubo
    • Organizer
      第46回 日本免疫学会
    • Data Source
      KAKENHI-PROJECT-16K21249
  • [Presentation] ΔNp63 regulate bronchial epithelial response: a potential mechanism of chronic airway inflammation2016

    • Author(s)
      Terufumi Kubo
    • Organizer
      第45回 日本免疫学会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-16K21249
  • 1.  TORIGOE Toshihiko (20301400)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 17 results
  • 2.  廣橋 良彦 (30516901)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 3.  塚原 智英 (20404634)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 13 results
  • 4.  金関 貴幸 (50531266)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 5.  中津川 宗秀 (70448596)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 6.  橋本 真一 (00313099)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  TSUJIWAKI Mitsuhiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  HASEGAWA Tadashi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  MASUMORI Naoya
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  水口 徹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 11.  江森 誠人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 12.  北村 寛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  斉藤 豪
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 14.  木島 敏樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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