BROWN John ＢｒｏｗｎＪｏｈｎ

… Alternative Names

Brown John Brown John

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Researcher Number	90583188
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 客員准教授
Affiliation (based on the past Project Information) *help	2016 – 2021: 京都大学, 医学研究科, 講師 2015: 京都大学, 医学(系)研究科(研究院), 講師 2014: 京都大学, 医学(系)研究科(研究院), 助教 2013: 京都大学, 薬学研究科(研究院), 研究員
Review Section/Research Field	Principal Investigator Environmental analyses and evaluation and related fields / System genome science Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Obstetrics and gynecology / Risk sciences of radiation and chemicals
Keywords	Principal Investigator 相互作用 / 計算創薬 / ケモジェノミクス / 化審法 / 安全性 / 受容体 / 画像化 / 評価統計選択 / AI / 可視化 … More / 安全評価 / 分子設計 / 能動的学習 / 人工知能 / 化学物質 / 核内受容体 / 国際研究者交流　フランス / 国際研究者交流　ドイツ / 分子ネットワーク / 機械学習 / 遺伝子発現 / バーチャルスクリーニング / ケモジェノミックス / オミックス / 臨床情報 / 分子相互作用 / トランスクリプトーム / マイクロアレイ / 個別化化学療法 / 遺伝子発言 / タンパク質 / 化合物 / 生命情報科学 / 統計パターン認識 / life science informatics / pattern recognition / comput. drug discovery / chemogenomics … More Except Principal Investigator 子宮体癌 / 卵巣癌 / PD-L1 / 免疫ダイナミクス / PD-1 / 免疫ゲノミクス / 婦人科がん / 腫瘍免疫 / 免疫チェックポイント / 免疫ダイナミズム / 婦人科腫瘍 / RNAシークエンス / 卵子体外培養 / がん生殖 / Figla / マウス二次卵胞 / 未熟卵子 / 抗腫瘍免疫逃避 / 化学療法抵抗性 / 子宮体部漿液性癌 / プラチナ耐性 / MDSC / マウスモデル / 動物モデル / 治療抵抗性 / 漿液性癌 / トランスレーショナルリサ―チ / ゲノム解析 / トランスレーショナルリサーチ / 卵巣明細胞癌 / 抗がん治療薬 / QSAR / ケモインフォマティクス / TK6細胞 / 変異原 / 発がん物質 / 遺伝毒物学 / 人体有害物質 / トキシコロジー Less

Development of tumor-host integrative therapies to overcome the refractory nature of uterine serous carcinoma
- Principal Investigator
  
  B Tsukasa
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Iwate Medical University
Development of a new in vitro culture system in secondary follicles of human children.
- Principal Investigator
  
  伊藤美幸
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kyoto University
Investigation of immune-suppressive dynamism and exploratory research for new treatment strategy for gynecologic cancer
- Principal Investigator
  
  Hamanishi Junzo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kyoto University
Construction of a platform for analysis of receptor binding by industrial chemicalsPrincipal Investigator
- Principal Investigator
  
  Brown John
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Environmental analyses and evaluation and related fields
- Research Institution
  Kyoto University
The genome analyses for advanced and recurrent ovarian clear cell carcinoma
- Principal Investigator
  
  Ikuo Konishi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Establishment of Novel Bioassays for in vivo Genotoxicity Prediction and Mechanism Characterization
- Principal Investigator
  
  Takeda Shunichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyoto University
Drug candidate discovery by development of a context-sensitive target network similarity metricPrincipal Investigator
- Principal Investigator
  
  Brown John
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  System genome science
- Research Institution
  Kyoto University

All 2021 2020 2019 2018 2017 2016 2014 2013 Other

All Journal Article Presentation Book

[Book] Practical Chemogenomic Modeling and Molecule Discovery Strategies Unveiled by Active Learning Systems Medicine: Integrative, Qualitative, and Computational Approaches, Reference Module in Biomedical Research (eds. Olaf Wolkenhauer and Ola Engkvist)2019
- Author(s)
  J.B. Brown
- Total Pages
  6
- Publisher
  Elsevier
- ISBN
  9780128160770
- Data Source
  KAKENHI-PROJECT-16H06306
[Book] Methods in Molecular Biology2018
- Author(s)
  Brown JB
- Total Pages
  1
- Publisher
  Springer Science+Business Media
- ISBN
  9781493986385
- Data Source
  KAKENHI-PROJECT-16H06306
[Book] Computational Chemogenomics. Methods in Molecular Biology, vol 18252018
- Author(s)
  J.B. Brown
- Total Pages
  452
- Publisher
  Humana Press
- ISBN
  9781493986385
- Data Source
  KAKENHI-PROJECT-17K20043
[Book] Selection of informative examples in chemogenomic datasets.2018
- Author(s)
  Reker D, Brown JB
- Total Pages
  41
- Publisher
  Springer Science+Business Media
- ISBN
  9781493986385
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] Combination of gene set signatures correlates with response to nivolumab in platinum-resistant ovarian cancer2021
- Author(s)
  Murakami R, Hamanishi J, Brown JB, Abiko K, Yamanoi K, Taki M, Hosoe Y, Yamaguchi K, Baba T, Matsumura N, Konishi I, Mandai M.
- Journal Title
  
  Sci Rep .
  
  Volume: 11 Issue: 1 Pages: 11427-11427
- DOI
  10.1038/s41598-021-91012-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09287, KAKENHI-PROJECT-18H02947, KAKENHI-PROJECT-21K09548, KAKENHI-PROJECT-20K21665
[Journal Article] Active learning effectively identifies a minimal set of maximally informative and asymptotically performant cytotoxic structure-activity patterns in NCI-60 cell lines.2020
- Author(s)
  Nakano T, Takeda S, Brown JB.
- Journal Title
  
  RSC Med Chem.
  
  Volume: 11 Issue: 9 Pages: 1075-1087
- DOI
  10.1039/d0md00110d
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] Prediction of Compound Cytotoxicity Based on Compound Structures and Cell Line Molecular Characteristics2020
- Author(s)
  Nakano T, Brown JB
- Journal Title
  
  J. Comput. Aided Chem.
  
  Volume: 21 Issue: 0 Pages: 1-10
- DOI
  10.2751/jcac.21.1
- NAID
  130007789661
- ISSN
  1345-8647
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] Systematic approaches to build predictive models for rat oral toxicity.2019
- Author(s)
  Polash AH, Nakano T, Takeda S, *Brown JB
- Journal Title
  
  CICSJ Bulletin
  
  Volume: 37 Pages: 12-21
- NAID
  130007639336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] Applicability Domain of Active Learning in Chemical Probe Identification: Convergence in Learning from Non-Specific Compounds and Decision Rule Clarification.2019
- Author(s)
  Polash AH, Nakano T, Takeda S, Brown JB
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 15 Pages: 2716-2716
- DOI
  10.3390/molecules24152716
- NAID
  120006712779
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] Classifiers and their Metrics Quantified2018
- Author(s)
  Brown J. B.
- Journal Title
  
  Molecular Informatics
  
  Volume: 37 Issue: 1-2 Pages: 1700127-1700127
- DOI
  10.1002/minf.201700127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K20043, KAKENHI-PROJECT-16H06306
[Journal Article] Selection of Informative Examples in Chemogenomic Datasets2018
- Author(s)
  Reker Daniel、Brown J. B.
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1825 Pages: 369-410
- DOI
  10.1007/978-1-4939-8639-2_13
- ISBN
  9781493986385, 9781493986392
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20043
[Journal Article] Chemogenomic Active Learning's Domain of Applicability on Small, Sparse qHTS Matrices: A Study Using Cytochrome P450 and Nuclear Hormone Receptor Families2018
- Author(s)
  Rakers Christin、Najnin Rifat Ara、Polash Ahsan Habib、Takeda Shunichi、Brown J.B.
- Journal Title
  
  ChemMedChem
  
  Volume: 13 Issue: 6 Pages: 511-521
- DOI
  10.1002/cmdc.201700677
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K20043, KAKENHI-PROJECT-16H06306
[Journal Article] Adaptive mining and model building of medicinal chemistry data with a multi-metric perspective.2018
- Author(s)
  Brown JB
- Journal Title
  
  Future Med Chem.
  
  Volume: 10 Issue: 16 Pages: 1885-1887
- DOI
  10.4155/fmc-2018-0188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-17H01587, KAKENHI-PROJECT-17K20043
[Journal Article] Active learning for computational chemogenomics.2017
- Author(s)
  Reker D, Schneider P, Schneider G, Brown JB
- Journal Title
  
  Future Med Chem.
  
  Volume: 9 Issue: 4 Pages: 381-402
- DOI
  10.4155/fmc-2016-0197
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-25870336
[Journal Article] Small Random Forest Models for Effective Chemogenomic Active Learning2017
- Author(s)
  Rakers C, Reker D, Brown JB
- Journal Title
  
  J. Comput. Aided Chem.
  
  Volume: 18 Issue: 0 Pages: 124-142
- DOI
  10.2751/jcac.18.124
- NAID
  130005877946
- ISSN
  1345-8647
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06306
[Journal Article] Exome Sequencing Landscape Analysis in Ovarian Clear Cell Carcinoma Shed Light on Key Chromosomal Regions and Mutation Gene Networks.2017
- Author(s)
  Murakami R, Matsumura N, Brown JB, Higasa K, Tsutsumi T, Kamada M, Abou-Taleb H, Hosoe Y, Kitamura S, Yamaguchi K, Abiko K, Hamanishi J, Baba T, Koshiyama M, Okuno Y, Yamada R, Matsuda F, Konishi I, Mandai M.
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 187 Issue: 10 Pages: 2246-2258
- DOI
  10.1016/j.ajpath.2017.06.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17KT0125, KAKENHI-PROJECT-17K19591, KAKENHI-PROJECT-17H01587, KAKENHI-PROJECT-16K15707
[Journal Article] Prediction of taxane and platinum sensitivity in ovarian cancer based on gene expression profiles2016
- Author(s)
  R Murakami, N Matsumura, J.B. Brown, Z Wang, K Yamaguchi, K Abiko, Y Yoshioka, J Hamanishi, T Baba, M Koshiyama, M Mandai, R Yamada, I Konishi
- Journal Title
  
  Gynecologic Oncology
  
  Volume: 141 Pages: 49-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870336
[Journal Article] Prediction of taxane and platinum sensitivity in ovarian cancer based on gene expression profiles.2016
- Author(s)
  Murakami R, Matsumura N, Brown JB, Wang Z, Yamaguchi K, Abiko K, Yoshioka Y, Hamanishi J, Baba T, Koshiyama M, Mandai M, Yamada R, Konishi I.
- Journal Title
  
  Gynecol Oncol.
  
  Volume: 141 Issue: 1 Pages: 49-56
- DOI
  10.1016/j.ygyno.2016.02.027
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253080, KAKENHI-PROJECT-25462590, KAKENHI-PROJECT-26670722, KAKENHI-PROJECT-26861324, KAKENHI-PROJECT-26293359, KAKENHI-PROJECT-25870336, KAKENHI-PROJECT-16K15707
[Journal Article] Reliable preeclampsia pathways based on multiple independent microarray data sets2014
- Author(s)
  Kaoru Kawasaki, Eiji Kondoh, Yoshitsugu Chigusa, Mari Ujita, Ryusuke Murakami, Haruta Mogami, J.B. Brown, Yasushi Okuno, Ikuo Konishi
- Journal Title
  
  Molecular Human Reproduction
  
  Volume: 21 Issue: 2 Pages: 217-224
- DOI
  10.1093/molehr/gau096
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25870336
[Journal Article] An Evolutionary Optimizer of libsvm Models2014
- Author(s)
  Dragos Horvath, J.B. Brown, Gilles Marcou, Alexandre Varnek
- Journal Title
  
  Challenges
  
  Volume: 5 Issue: 2 Pages: 450-472
- DOI
  10.3390/challe5020450
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25870336
[Journal Article] Constructing a foundational platform driven by Japan's K supercomputer for next-generation drug discovery2014
- Author(s)
  J.B. Brown*, Masahiko Nakatsui*, Yasushi Okuno
- Journal Title
  
  Molecular Informatics
  
  Volume: 33 Issue: 11-12 Pages: 732-741
- DOI
  10.1002/minf.201400067
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25870336
[Journal Article] Computational chemogenomics - is it more than inductive transfer?2014
- Author(s)
  J.B. Brown, Yasushi Okuno, Gilles Marcou, Alexandre Varnek, Dragos Horvath
- Journal Title
  
  Journal of Computer-Aided Molecular Design
  
  Volume: 28 Issue: 6 Pages: 597-618
- DOI
  10.1007/s10822-014-9743-1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25870336
[Journal Article] Computational chemogenomics - is it more than inductive transfer?2014
- Author(s)
  J.B. Brown, Y. Okuno, G. Marcou, A. Varnek, D. Horvath
- Journal Title
  
  Journal of Computer-Aided Molecular Design
  
  Volume: 28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870336
[Journal Article] Compound-protein interaction prediction within chemogenomics: theoretical concepts, practical usage, and future directions2013
- Author(s)
  J.B. Brown, S. Niijima, Y. Okuno
- Journal Title
  
  Molecular Informatics
  
  Volume: 32 Issue: 11-12 Pages: 906-906
- DOI
  10.1002/minf.201300101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] ビッグデータとAIの実態および適用範囲を定量的に明確にする能動的学習の紹介2020
- Author(s)
  J.B. Brown
- Organizer
  協和キリン株式会社セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] 主流となってきた「ビッグデータAI」の必要性を覆す新人工知能基盤の確立2020
- Author(s)
  J.B. Brown
- Organizer
  メディカルジャパン2020
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] 主流となってきた「ビッグデータAI」の必要性を覆す新人工知能基盤の確立2019
- Author(s)
  J.B. Brown
- Organizer
  バイオインダストリー協会セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] 人工知能(AI)の実態及びAIによる創薬研究活動の加速化の近未来2019
- Author(s)
  J.B. Brown
- Organizer
  第一三共株式会社セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] 実応用に向けて「能動的計算創薬」の展望2019
- Author(s)
  J.B. Brown
- Organizer
  芝蘭会　産学情報交流会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Visualizations within chemogenomic active learning reveal how protein descriptors are used and underlying truths about chemogenomic and single target QSAR model utility.2019
- Author(s)
  J.B. Brown
- Organizer
  Asian Hub for e-Drug Discovery (AHeDD) 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Data volume and tactical decisions for virtual screening-accelerated drug discovery2019
- Author(s)
  J.B. Brown
- Organizer
  ETH RETHINK seminar
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Passenger fusion genes are novel predictive biomarker of anti-PD-1 antibody nivolumab for ovarian cancer2019
- Author(s)
  Junzo Hamanishi, Ryusuke Murakami, John B Brown, Tsukasa Baba, Eiji Suzuki, Kaoru Abiko, Masaki Mandai
- Organizer
  50th Annual Meeting on Women's Cancer (SGO 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02945
[Presentation] Differential transcriptomic analysis of secondary follicles in mature and premature mice toward the elucidation of key molecular factors applicable to the establishment of in vitro follicular culture systems.2019
- Author(s)
  Asuka Okunomiya, Yoshimi Kitawaki, Yusuke Sagae, Akihito Horie, Hirohiko Tani, Yukiyasu Sato, Miki Sugimoto, J.B. Brown, Masaki Mandai
- Organizer
  第71回　日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K19613
[Presentation] Adaptive Pattern Extraction Underpins Rethinking the Role of Big Data2019
- Author(s)
  Brown JB
- Organizer
  ETH Zurich RETHINK Kickoff Symposium
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Active learning of ligand-target interactions to build minimally complex yet maximally predictive interaction models2018
- Author(s)
  J.B. Brown
- Organizer
  International Chemical Biology Society Annual Meeting 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] Why adaptively-built simple models using small datasets can be sufficient for chemical modeling2018
- Author(s)
  J.B. Brown
- Organizer
  Chemoinformatics Strasbourg Summer School (CS3)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] Active learning part 2 - assorted topics: de-orphanization, active projections, and hybridization with cross-validation2018
- Author(s)
  Brown JB
- Organizer
  University of Bonn Workshop on Computational Chemical Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Binary classification metric surfaces2018
- Author(s)
  Brown JB
- Organizer
  University of Bonn Workshop on Computational Chemical Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] 生命科学と医薬学における人工知能の応用及び人工知能の最新評価方法論2018
- Author(s)
  J.B. Brown
- Organizer
  岐阜大学情報学研究科　生命情報集中講義
- Invited
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] Dynamic selection of ligand-target pairs toward construction of a minimal-size training set for chemogenomic model building2018
- Author(s)
  J.B. Brown
- Organizer
  Vertex Pharmaceuticals internal seminar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] Adaptive pattern extraction underpins rethinking the role of big data2018
- Author(s)
  J.B. Brown
- Organizer
  ETH RETHINK kickoff symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] Frontiers Unveiled by Active Learning2018
- Author(s)
  Brown JB, Rakers C, Polash A, Nakano T
- Organizer
  Asian Hub for e-Drug Discovery 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] 能動的学習による化合物モデリング、および、導かれた機械学習の真実2018
- Author(s)
  Brown JB
- Organizer
  第41回ケモインフォマティクス討論会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Dynamic selection of ligand-target pairs toward construction of a minimal-size training set for chemogenomic model building2018
- Author(s)
  J.B. Brown
- Organizer
  Vertex Pharmaceuticals Molecular Modeling Group Seminar
- Invited
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] Passenger fusion genes are novel predictive biomarker of anti-PD-1 antibody nivolumab for ovarian cancer.2018
- Author(s)
  Junzo Hamanishi, Ryusuke Murakami, John B Brown, Tsukasa Baba, Eiji Suzuki, Kaoru Abiko, Masaki Mandai
- Organizer
  The 50th of American Association for Cancer Research (AACR 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02945
[Presentation] Active learning part 1 - concepts and chemogenomic examples2018
- Author(s)
  Brown JB
- Organizer
  University of Bonn Workshop on Computational Chemical Biology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Binary classification metric surfaces2018
- Author(s)
  J.B. Brown
- Organizer
  University of Bonn Open Workshop Computational Chemical Biology and Chemogenomics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] 構造活性相関情報を効率的に選択する能動的学習の医薬品開発応用への最新結果と課題2018
- Author(s)
  Brown JB
- Organizer
  構造活性フォーラム2018
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Frontiers Unveiled by Active Learning2018
- Author(s)
  J.B. Brown
- Organizer
  Asian Hub for e-Drug Discovery (AHeDD) 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] Searching for the right ligand-target interaction predictions to validate by physics-based methods2018
- Author(s)
  J.B. Brown
- Organizer
  Osaka University Institute for Protein Research seminar
- Invited
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] Active learning of ligand-target interactions to build minimally complex yet maximally predictive interaction models2018
- Author(s)
  Brown JB
- Organizer
  International Chemical Biology Society 2018 Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Chemogenomic active learning, including an in-depth look at classification metrics2018
- Author(s)
  J.B. Brown
- Organizer
  OpenEye CUP XVIII
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] Chemogenomic active learning - new frontiers based on an old concept2018
- Author(s)
  J.B. Brown
- Organizer
  OpenEye JCUP IX
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] The nature of metrics used to evaluate binary classifier models in drug discovery and design2018
- Author(s)
  J.B. Brown
- Organizer
  ETH Zurich Department of Chemistry and Applied Biosciences seminar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] 構造活性相関情報を効率的に選択する能動的学習の医薬品開発応用への最新結果と課題2018
- Author(s)
  J.B. Brown
- Organizer
  構造活性フォーラム2018
- Invited
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] 二次卵胞の比較トランスクリプトーム解析に基づいた小児卵胞体外培養系における必要分子の考察2018
- Author(s)
  奥宮明日香、寒河江悠介、上田　匡、谷　洋彦、堀江昭史、佐藤幸保、杉本実紀、Brown, J.B.、万代昌紀
- Organizer
  日本受精着床学会
- Data Source
  KAKENHI-PROJECT-18K19613
[Presentation] Less is more: distilling human interpretable simplicity from models of large qHTS result matrices.2017
- Author(s)
  Brown JB
- Organizer
  100th RACI Congress, Asian Hub for e-Drug Discovery Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Active learning for computational chemogenomics2017
- Author(s)
  J.B. Brown
- Organizer
  記者会見
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] Finding the essential gems in your assay data: the chemogenomic active learning method2017
- Author(s)
  J.B. Brown
- Organizer
  NIH/NIEHS Internal Seminar
- Data Source
  KAKENHI-PROJECT-17K20043
[Presentation] Smashing phantoms: rectifying views on big data and complex AI in drug discovery and chemical biology.2017
- Author(s)
  Brown JB
- Organizer
  3rd Bioinformatics Agora
- Invited
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Why small data and simple models still make sense for therapy discovery.2017
- Author(s)
  Brown JB
- Organizer
  Kyoto University-Boehringer Ingelheim joint research meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306
[Presentation] Do you really need big data for drug discovery and repurposing? A critical investigation.2016
- Author(s)
  J.B. Brown
- Organizer
  第15回駿河台シンポジウム/第7回難治疾患共同研究拠点シンポジウム
- Place of Presentation
  東京医科歯科大学
- Invited
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] Next-generation life-science informatics: the ongoing explosion of data2016
- Author(s)
  J.B. Brown
- Organizer
  ビッグデータストレージ時代研究会（主催者：㈱ニューテック）
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] An approach to finding a reduced set of key ligand-target pairs in chemogenomic datasets2016
- Author(s)
  J.B. Brown
- Organizer
  京都大学医学研究科形態形成機構学研究室
- Place of Presentation
  京都大学
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] Visualization for computational chemogenomics2016
- Author(s)
  J.B. Brown
- Organizer
  NII Shonan Meeting on Web Molecular Graphics
- Place of Presentation
  湘南
- Year and Date
  2016-09-05
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] Computational chemogenomics: core concepts, applications, and critical aspects of model building2016
- Author(s)
  J.B. Brown
- Organizer
  東京電気大学ケモインフォマティクスと構造解析の講義シリーズ
- Place of Presentation
  東京電気大学
- Invited
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] Leveraging the power of the K computer for chemogenomics -- what have we done, and what do we need to do?2014
- Author(s)
  J.B. Brown
- Organizer
  RIKEN Advanced Institute for Computational Science seminar series
- Place of Presentation
  神戸
- Year and Date
  2014-07-04
- Invited
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] Polypharmacology, promiscuity, and perplexity2013
- Author(s)
  J.B. Brown
- Organizer
  JCUP IV
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] Chemogenomics: theory, translational benefits, and challenges2013
- Author(s)
  J.B. Brown
- Organizer
  University of Bonn Life Science Informatics Retreat 2013
- Place of Presentation
  ボン大学、ドイツ
- Invited
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] 生命ネットワーク分子科学の中心となっている化合物の研究進展と化学情報学の重要性2013
- Author(s)
  J.B. Brown
- Organizer
  日本化学会情報化学部会第一回若手の会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] In Silico Methods for Chemogenomic Predictions and Application to Analyses of Major Drug Target Families2013
- Author(s)
  J.B. Brown, S. Niijima, Y. Okuno
- Organizer
  The 2nd HD Physiology International Symposium
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] Systems Chemical Biology via Computational Compound-Protein Interaction Prediction: Core Ideas, Translational Validity, and Important Perspectives2013
- Author(s)
  J.B. Brown
- Organizer
  Autumn Schoo of Chemoinformatics in Nara
- Place of Presentation
  奈良
- Invited
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] Resisting the black box: more than just SVMs for data analysis2013
- Author(s)
  J.B. Brown
- Organizer
  University of Bonn Life Science Informatics Retreat 2013
- Place of Presentation
  ボン大学、ドイツ
- Invited
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] Reductionism and Chemogenomics: Conflicting or Complementary2013
- Author(s)
  J.B. Brown
- Organizer
  Strasbourg University Dept. of Chemoinformatics
- Place of Presentation
  ストラスブール大学、フランス
- Invited
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] Next-generation life science informaticians2013
- Author(s)
  J.B. Brown
- Organizer
  University of Bonn Life Science Informatics Retreat 2013
- Place of Presentation
  ボン大学、ドイツ
- Invited
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] Drug discovery and the need for new post-ligation downstream network analysis algorithms incorporating contextualization2013
- Author(s)
  J.B. Brown
- Organizer
  KUBIC-NII Joint Seminar on Bioinformatics 2013
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-25870336
[Presentation] Computational chemogenomics - is it more than inductive transfer?
- Author(s)
  J.B. Brown, Y. Okuno, G. Marcou, A. Varnek, D. Horvath(*)
- Organizer
  Chemical Computing Group User Group Meeting and Conference 2014
- Place of Presentation
  ストラスブール、フランス
- Year and Date
  2014-04-22 – 2014-04-25
- Data Source
  KAKENHI-PROJECT-25870336

1. 村上隆介 (40782363)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. 安彦郁 (20508246)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 万代昌紀 (80283597)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. Takeda Shunichi (60188191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. Ikuo Konishi (90192062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. B Tsukasa (60508240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. Hamanishi Junzo (80378736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. 廣田耕志 (00342840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 笹沼博之 (00531691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 安井学 (50435707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 津田雅貴 (00734104)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 松村謙臣 (20452336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 山口建 (20378772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 森誠一 (10334814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 日笠幸一郎 (10419583)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. 山田亮 (50301106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 榎本隆之 (90283754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 伊藤美幸 (00760951)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 佐藤幸保 (00508236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. 杉本実紀 (20243074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. 堀江昭史 (30535836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. 谷洋彦 (70615252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
23. 茶本健司 (50447041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SCHNEIDER Gisbert

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. REKER Daniel

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

BROWN John Ｂｒｏｗｎ Ｊｏｈｎ

Brown John Brown John

Research Projects

Research Products

Co-Researchers

Development of tumor-host integrative therapies to overcome the refractory nature of uterine serous carcinoma

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Development of a new in vitro culture system in secondary follicles of human children.

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Investigation of immune-suppressive dynamism and exploratory research for new treatment strategy for gynecologic cancer

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Construction of a platform for analysis of receptor binding by industrial chemicalsPrincipal Investigator

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The genome analyses for advanced and recurrent ovarian clear cell carcinoma

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Establishment of Novel Bioassays for in vivo Genotoxicity Prediction and Mechanism Characterization

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Drug candidate discovery by development of a context-sensitive target network similarity metricPrincipal Investigator

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[Book] Practical Chemogenomic Modeling and Molecule Discovery Strategies Unveiled by Active Learning Systems Medicine: Integrative, Qualitative, and Computational Approaches, Reference Module in Biomedical Research (eds. Olaf Wolkenhauer and Ola Engkvist)2019

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[Book] Methods in Molecular Biology2018

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[Book] Computational Chemogenomics. Methods in Molecular Biology, vol 18252018

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[Book] Selection of informative examples in chemogenomic datasets.2018

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[Journal Article] Combination of gene set signatures correlates with response to nivolumab in platinum-resistant ovarian cancer2021

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[Journal Article] Active learning effectively identifies a minimal set of maximally informative and asymptotically performant cytotoxic structure-activity patterns in NCI-60 cell lines.2020

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BROWN John ＢｒｏｗｎＪｏｈｎ