MORITOKI YUKI 守時由起

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MORITOKI Yuki 守時由起

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Researcher Number	90585522
Other IDs
Affiliation (Current)	2026: 秋田大学, 医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2026: 秋田大学, 医学系研究科, 准教授 2022 – 2024: 秋田大学, 医学系研究科, 准教授 2019 – 2021: 秋田大学, 医学部附属病院, 特任准教授 2018: 秋田大学, 医学部附属病院, 特任講師 2016: 秋田大学, 医学部, 特任講師 2011 – 2015: 秋田大学, 医学部, 講師 2010 – 2011: 秋田大学, 医学部, 特任講師
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Medical pharmacy
Keywords	Principal Investigator B細胞除去療法 / 原発性胆汁性胆管炎 / 原発性胆汁性肝硬変 / B細胞除去 / PBC / B細胞 / MUSE細胞移植 / 抗CD20抗体 / マウス / ヒトCD20 … More / 抗治療薬抗体 / マウスモデル / 動物モデル / 炎症制御細胞 / IL-10 / 原発性胆汁性肝硬変(原発性胆汁性胆管炎) / CD5 / CD20 … More Except Principal Investigator 好酸球 / 気道上皮細胞 / PGD2 / GPER / CCR3 / CRTH2 / DP / アレルギー炎症 / ケモカイン受容体CCR3 / PGD2受容体 / プロスタグランジンD2 Less

好酸球性炎症に着目した原発性胆汁性胆管炎の病態解明Principal Investigator
- Principal Investigator
  
  守時由起
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Akita University
MUSE cell tranfer study to examine tissue repair promotion in B cell depleted PBC model micePrincipal Investigator
- Principal Investigator
  
  守時由起
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Akita University
Persistence of therapeutic effect and prolongation of therapeutic interval after B-cell depletion in mice with primary biliary cholangitisPrincipal Investigator
- Principal Investigator
  
  MORITOKI Yuki
- Project Period (FY)
  2019 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Akita University
Exploring therapeutic efficacy of B cell depletion-combined regulatory plasma cell transfer in PBCPrincipal Investigator
- Principal Investigator
  
  MORITOKI Yuki
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
Analysis of Regulatory B cell Distribution and Function in Primary Biliary Cirrhosis (Cholangitis) Model Mice and Optimization of B cell Targeted TherapyPrincipal Investigator
- Principal Investigator
  
  Moritoki Yuki
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University
Possible novel receptor and its signaling pathway for prostaglandin D2
- Principal Investigator
  
  OYAMADA Hajime
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Akita University
Identification of regulatory B cells in a murine model of primary biliary cirrhosis and fundamental examination for clinical applicationPrincipal Investigator
- Principal Investigator
  
  MORITOKI Yuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Gastroenterology
- Research Institution
  Akita University

All 2019 2018 2016 2014 2013 2012 2011 2010 Other

All Journal Article Presentation Patent

[Journal Article] Anti-drug Antibodies Against a Novel Humanized Anti-CD20 Antibody Impair Its Therapeutic Effect on Primary Biliary Cholangitis in Human CD20- and FcγR-Expressing Mice2018
- Author(s)
  Moritoki Y, Tsuneyama K, Nakamura Y, Kikuchi K, Shiota A, Ohsugi Y, Lian ZX, Zhang W, Yang GX, Ueki S, Takeda M, Omokawa A, Saga T, Saga A, Watanabe D, Miura M, Ueno Y, Leung PSC, Tanaka A, Gershwin ME, Hirokawa M.
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 9 Pages: 2534-2534
- DOI
  10.3389/fimmu.2018.02534
- NAID
  120006937682
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08926, KAKENHI-PROJECT-18K07069, KAKENHI-PROJECT-15KK0329, KAKENHI-PROJECT-15K08982
[Journal Article] Expression and functional roles of G-protein-coupled estrogen receptor (GPER) in human eosinophils.2014
- Author(s)
  Tamaki M, Konno Y, Kobayashi Y, Takeda M, Itoga M, Moritoki Y, Oyamada H, Kayaba H, Chihara J, Ueki S.
- Journal Title
  
  Immunology Letters
  
  Volume: 160 Issue: 1 Pages: 72-78
- DOI
  10.1016/j.imlet.2014.03.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590169, KAKENHI-PROJECT-25460670
[Journal Article] Expression and functional roles of G-protein-coupled estrogen receptor (GPER) in human eosinophils2014
- Author(s)
  Tamaki M, Konno Y, Kobayashi Y, Takeda M, Itoga M, Moritoki Y, Oyamada H, Kayaba H, Chihara J, Ueki S
- Journal Title
  
  Immunol Lett
  
  Volume: 160(1) Issue: 1 Pages: 72-78
- DOI
  10.1016/j.imlet.2014.03.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590169
[Journal Article] Splenic lymph follicles generate immunoglobulin M-producing B cells in primary biliary cirrhosis.2014
- Author(s)
  Kikuchi K, Tsuneyama K, Yamada H, Kajiyama Y, Matsumoto K, Tsunashima H, Yamashita R, Takai A, Negishi M, Hara M, Moritoki Y, Miyakawa H.
- Journal Title
  
  Hepatol Res.
  
  Volume: in press Issue: 10
- DOI
  10.1111/hepr.12231
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390181, KAKENHI-PROJECT-24590952
[Journal Article] Adiponectin attenuates human eosinophil adhesion and chemotaxis: implications in allergic inflammation.2013
- Author(s)
  Yamamoto R, Ueki S, Moritoki Y, Kobayashi Y, Oyamada H, Konno Y, Tamaki M, Itoga M, Takeda M, Ito W, Chihara J.
- Journal Title
  
  Journal of Asthma
  
  Volume: 50 Issue: 8 Pages: 828-835
- DOI
  10.3109/02770903.2013.816725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590169, KAKENHI-PROJECT-25460670
[Journal Article] Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid2012
- Author(s)
  Tsuda M, Moritoki Y, Lian ZX, Zhang W, Yoshida K, Wakabayashi K, Yang GX, Nakatani T, Vierling J, Lindor K, Gershwin ME, Bowlus CL
- Journal Title
  
  Hepatology
  
  Volume: 55 Issue: 2 Pages: 512-21
- DOI
  10.1002/hep.24748
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890024
[Journal Article] Comparative analysis of portal cell infiltrates in antimitochondrial autoantibody-positive versus antimitochondrial autoantibody-negative primary biliary cirrhosis2012
- Author(s)
  Jin Q, Moritoki Y, Lleo A, Tsuneyama K, Invernizzi P, Moritoki H, Kikuchi K, Lian ZX, Hirschfield GM, Ansari AA, Coppel RL, Gershwin ME, Niu J
- Journal Title
  
  Hepatology
  
  Volume: 55 Issue: 5 Pages: 1495-506
- DOI
  10.1002/hep.25511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890024, KAKENHI-PROJECT-24390181
[Journal Article] B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD. c3c4 model of autoimmune cholangitis2011
- Author(s)
  Moritoki Y, Tsuda M, Tsuneyama K, Zhang W, Yoshida K, Lian ZX, Yang GX, Ridgway WM, Wicker LS, Ansari AA, Gershwin ME
- Journal Title
  
  Cell Immunol
  
  Volume: 268 Pages: 16-23
- URL
  http://www.sciencedirect.com/science/article/pii/S0008874911000153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890024
[Journal Article] B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis2011
- Author(s)
  Yuki Moritoki, et al
- Journal Title
  
  Cell Immunol
  
  Volume: VOL.268 Pages: 16-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890024
[Journal Article] Pathological Features of New Animal Models for Primary Biliary Cirrhosis2011
- Author(s)
  Tsuneyama K, Moritoki Y, Kikuchi K, Nakanuma Y
- Journal Title
  
  International Journal of Hepatology
  
  Volume: 2012 Pages: 1-7
- NAID
  120004186279
- URL
  http://www.hindawi.com/journals/ijhep/2012/403954/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890024
[Journal Article] Murine models of autoimmune cholangitis2010
- Author(s)
  Ueno Y, Ambrosini YM, Moritoki Y, et al
- Journal Title
  
  Curr Opin Gastroenterol
  
  Volume: 26 Pages: 274-279
- Data Source
  KAKENHI-PROJECT-22890024
[Journal Article] Murine models of autoimmune cholangitis2010
- Author(s)
  Ueno Y, Ambrosini YM, Moritoki Y, Ridgway WM, Gershwin ME
- Journal Title
  
  Curr Opin Gastroenterol
  
  Volume: 26 Issue: 3 Pages: 274-9
- DOI
  10.1097/mog.0b013e32833755aa
- Data Source
  KAKENHI-PROJECT-22890024
[Patent] ヒト特定分子およびヒトFcγ受容体ファミリーを発現するトランスジェニック非ヒト動物2016
- Inventor(s)
  塩田　明、溝呂木達也、守時由起
- Industrial Property Rights Holder
  株式会社特殊免疫研究所、国立大学法人　秋田大学
- Industrial Property Rights Type
  特許
- Filing Date
  2016-04-28
- Overseas
- Data Source
  KAKENHI-PROJECT-15K08982
[Presentation] B cell Targeting Immunotherapy in Primary Biliary Cholangitis.2019
- Author(s)
  Moritoki Y.
- Organizer
  2019 SCUT International Symposium of Liver Immunology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08982
[Presentation] Efficacy of humaniazed anti-human CD20 on Early Stage Murine Autoimmune Cholangitis using human CD20 and FcγR expressing dnTGFβRII Mice.2018
- Author(s)
  Moritoki Y, et al.
- Organizer
  The Liver Meeting 2018 (米国肝臓学会総会) in San Francisco
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08982
[Presentation] Pharmacological PI3kγ　inhibitor attenuates eotaxin-induced human eosinophil functions2014
- Author(s)
  Yukiko Saito,Masahide Takeda,Yasunori Konno,Mami Tamaki,Yuki Moritoki,Shigeharu Ueki,Hajime Oyamada,Makoto Hirokawa
- Organizer
  第63回日本医学検査学会
- Place of Presentation
  新潟市
- Data Source
  KAKENHI-PROJECT-23590169
[Presentation] Adiponectin attenuates human eosinophil adhesion and chemotaxis.2013
- Author(s)
  Ueki S, Yamamoto R, Moritoki Y, Kobayashi Y, Oyamada H, Konno Y, Tamaki Y, Itoga M, Takeda M, Chihara J.
- Organizer
  8th Biennial symposium of the international eosinophil society.
- Place of Presentation
  Oxford. UK.
- Data Source
  KAKENHI-PROJECT-23590169
[Presentation] Adiponectin attenuates human eosinophil adhesion and chemotaxis2013
- Author(s)
  Ueki S, Yamamoto R, Moritoki Y, Kobayashi Y, Oyamada H, Konno Y, Tamaki Y, Itoga M, Takeda M, Chihara J
- Organizer
  8th Biennial symposium of the international eosinophil society
- Place of Presentation
  Oxford. UK
- Data Source
  KAKENHI-PROJECT-23590169
[Presentation] B cell immunity in Primary Biliary Cirrhosis2012
- Author(s)
  Yuki Moritoki
- Organizer
  First China-Japan Symposium on Autoimmune Liver Disease
- Place of Presentation
  Hefei, China
- Invited
- Data Source
  KAKENHI-PROJECT-24590952
[Presentation] A critical role of B cells in biliary disease and sialadenitis in the NOD.c3c4 model of autoimmune cholangitis2011
- Author(s)
  Yuki Moritoki, et al.
- Organizer
  Immunology 2011, 98^<th> Annual Meeting The American Association of Immunologists
- Place of Presentation
  Moscone Center, (San Francisco, CA, USA)
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] 自己免疫性胆管炎モデルNOD. c3c4マウスにおける胆管炎および唾液腺炎に対するB細胞の炎症促進的役割2011
- Author(s)
  守時由起, 常山幸一, M. E. Gershwin
- Organizer
  第15回日本肝臓学会大会(第19回日本消化器病関連学会週間)
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] PBC患者体内におけるIgM産生の場についての検討2011
- Author(s)
  菊池健太郎, 常山幸一, 守時由起, 細谷直美, 梶山祐介, 高井敦子, 根岸雅嗣, 原眞純, 水口國雄, 宮川浩
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] 原発性胆汁性肝硬変におけるTGF-βシグナル伝達機構の解析2011
- Author(s)
  川村梨那子, 松崎恒一, 吉田勝紀, 常山幸一, 守時由起, 井口亮輔, 村田美樹, 山口隆志, 仲野俊成, 廣原淳子, 関寿人, 岡崎和一
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] 自己免疫性胆管炎モデルNOD.c3c4マウスにおける胆管炎および唾液腺炎に対するB細胞の炎症促進的役割2011
- Author(s)
  守時由起, 他
- Organizer
  第15回日本肝臓学会大会
- Place of Presentation
  福岡国際会議場(福岡県)
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] 核酸アナログ治療後、B型慢性肝疾患の線維化・癌化シグナルは回帰する2011
- Author(s)
  吉田勝紀, Long Qing, 松崎恒一, 常山幸一, 守時由起, Zhe-Xiong Lian, Junqi Niu, 井口亮輔, 村田美樹, 川村梨那子, 山口隆志, 関寿人, 岡崎和一
- Organizer
  第47回日本肝臓学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] A critical role of B cells in biliary disease and sialadenitis in the NOD. c3c4 model of c3c4 model ofautoimmune chautoimmune cholangitis2011
- Author(s)
  Yuki Moritoki, Masanobu Tsuda, Koichi Tsuneyama, Weici Zhang, Katsunori Yoshida, Zhe-Xiong Lian, Guo-Xiang Yang, William M. Ridgway Linda S., Wicker, Aftab, A. Ansari, M. Eric Gershwin
- Organizer
  Immunology 2011
- Place of Presentation
  San Francisco, US
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] CD45ROhighCD57+CD8high T cells in primary biliary cirrhosis2011
- Author(s)
  Masanobu Tsuda, Yoko Ambrosini, Yuki Moritoki, Katsunori Yoshida, Weici Zhang, Guo-Xiang Yang, Yugo Ando, Guanghua Rong, Toshio Nakatani, Christopher Bowlus, Aftab Ansari, Zhe-Xiong Lian, M. Eric Gershwin
- Organizer
  Immunology 2011
- Place of Presentation
  San Francisco, US
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] Disease course dependent opposite roles of B cells to pathogenesis and pathophysiology of autoimmune cholangitis in dnTGF-βRII mice2010
- Author(s)
  Y. Moritoki, Z. Lian, K. Tsuneyama, W. Zhang, K. Yoshida, K. Wakabayashi, G. Yang, Y. Ueno, M. Gershwin
- Organizer
  14^<th>International Congress of Immunology
- Place of Presentation
  Kobe Japan
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] C型慢性肝炎患者における血清B cell activating factor (BAFF)濃度と橋本病の関連および血清Estrogenの影響2010
- Author(s)
  梶山祐介, 河井敏宏, 高井敦子, 本田宗宏, 細谷直美, 守時由起, 宮川浩, 菊池健太郎
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] 抗CD20抗体療法による自己免疫性胆管炎の改善および腸炎の増悪2010
- Author(s)
  守時由起, Zhe-Xiong LIAN, 常山幸一, Weici Zhang, 菊池健太郎, 宮川浩, 上野義之, M. Eric GERSHWIN
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] 抗CD20抗体療法による自己免疫性胆管炎の改善および腸炎の増悪2010
- Author(s)
  守時由起, 他
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形国際ホテル(山形県)
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] Disease course dependent opposite roles of B cells to pathogenesis and pathophysiology of autoimmune cholangitis in dnTGF-ssRII mice2010
- Author(s)
  Y.Moritoki, et al
- Organizer
  14^<th> International Congress of Immunology
- Place of Presentation
  Kobe International Exhibition Hall (Hyogo, Japan)
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] Monosodium Glutamate投与NASHモデルマウスにおけるメタボリックシンドロームの検討2010
- Author(s)
  高井敦子, 梶山祐介, 河井敏宏, 根岸雅嗣, 藤本誠, 細谷直美, 蔵野信, 守時由起, 常山幸一, 原眞純, 塚本和久, 宮川浩, 菊池健太郎
- Organizer
  第46回日本肝臓学会総会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-22890024
[Presentation] Pharmacological PI3k gamma inhibitor attenuates eotaxin-induced human eosinophil functions
- Author(s)
  Yukiko Saito, Masahide Takeda, Yasunori Konno, Mami Tamaki, Yuki Moritoki, Shigeharu Ueki, Hajime Oyamada, Makoto Hirokawa
- Organizer
  第63回日本医学検査学会
- Place of Presentation
  新潟市
- Data Source
  KAKENHI-PROJECT-23590169

1. CHIHARA Junichi (80197615)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
2. OYAMADA Hajime (80375310)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. UEKI Shigeharu (60361234)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
4. TSUNEYAMA koichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. KIKUCHI kentaro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

MORITOKI YUKI 守時 由起

MORITOKI Yuki 守時 由起

Research Projects

Research Products

Co-Researchers

好酸球性炎症に着目した原発性胆汁性胆管炎の病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

MUSE cell tranfer study to examine tissue repair promotion in B cell depleted PBC model micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Persistence of therapeutic effect and prolongation of therapeutic interval after B-cell depletion in mice with primary biliary cholangitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring therapeutic efficacy of B cell depletion-combined regulatory plasma cell transfer in PBCPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of Regulatory B cell Distribution and Function in Primary Biliary Cirrhosis (Cholangitis) Model Mice and Optimization of B cell Targeted TherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Possible novel receptor and its signaling pathway for prostaglandin D2

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of regulatory B cells in a murine model of primary biliary cirrhosis and fundamental examination for clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Anti-drug Antibodies Against a Novel Humanized Anti-CD20 Antibody Impair Its Therapeutic Effect on Primary Biliary Cholangitis in Human CD20- and FcγR-Expressing Mice2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Expression and functional roles of G-protein-coupled estrogen receptor (GPER) in human eosinophils.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression and functional roles of G-protein-coupled estrogen receptor (GPER) in human eosinophils2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Splenic lymph follicles generate immunoglobulin M-producing B cells in primary biliary cirrhosis.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Adiponectin attenuates human eosinophil adhesion and chemotaxis: implications in allergic inflammation.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biochemical and immunologic effects of rituximab in patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparative analysis of portal cell infiltrates in antimitochondrial autoantibody-positive versus antimitochondrial autoantibody-negative primary biliary cirrhosis2012

Author(s)

MORITOKI YUKI 守時由起

MORITOKI Yuki 守時由起

[Patent] ヒト特定分子およびヒトFcγ受容体ファミリーを発現するトランスジェニック非ヒト動物2016

[Presentation] Pharmacological PI3kγ　inhibitor attenuates eotaxin-induced human eosinophil functions2014