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OHKUBO TAKUYA  大久保 卓哉

… Alternative Names

OHKUBO Takuya  大久保 卓哉

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Researcher Number 90587461
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-2014-3650
Affiliation (Current) 2025: 東京科学大学, その他の部局等, 非常勤講師
Affiliation (based on the past Project Information) *help 2013: 東京医科歯科大学, 医歯(薬)学総合研究科, 助教
2010 – 2012: 東京医科歯科大学, 大学院・医歯学総合研究科, 助教
Review Section/Research Field
Principal Investigator
Neurology
Except Principal Investigator
Neurology
Keywords
Principal Investigator
TDP-43 / リン酸化 / 伝播 / AAVベクター / 経シナプス伝播 / 霊長類モデル / ALS / AAV / 筋萎縮性側索硬化症 / ラットモデル / 筋萎縮性側索硬化症(ALS) … More
Except Principal Investigator
… More 伝播 / TDP-43 / ラット / ALS Less
  • Research Projects

    (3 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (5 People)
  •  Development of rat model of TDP-43 propagation

    • Principal Investigator
      KANOUCHI Tadashi
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University
  •  Mechanism of transsynpatic retrograde transport in non-human primate model of ALSPrincipal Investigator

    • Principal Investigator
      OHKUBO TAKUYA
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University
  •  Establishment for rat model of sporadic amyotrophic lateral sclerosisPrincipal Investigator

    • Principal Investigator
      OHKUBO Takuya
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Neurology
    • Research Institution
      Tokyo Medical and Dental University

All 2014 2013 2012 2011

All Journal Article Presentation Book

  • [Book] Annual Review 神経2014;筋萎縮性側索硬化症(ALS)における疾患の発症と病態進展機序2014

    • Author(s)
      関口輝彦,阿部圭輔,大久保卓哉,叶内匡,横田隆徳
    • Total Pages
      10
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-24689039
  • [Book] 筋萎縮性側索硬化症(ALS)における疾患の発症と病態進展機序 (In : Annual Review 2014神経)2014

    • Author(s)
      関口輝彦,阿部圭輔,大久保卓哉,叶内匡,横田隆徳.編集:鈴木則宏,祖父江元,荒木信夫,宇川義一,川原信隆
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-24689039
  • [Journal Article] Non-human primate model of ALS with cytoplasmic mislocalizaion of TDP-43. Brain2012

    • Author(s)
      Uchida A, Sasaguri H, Kimura N, TajiriM, Ono F, Ohkubo T, Sakaue F, Kanai K, Hirai T, Sano T, Shibuya K, Kobayashi M, Ueno T, Yamamoto M, Kubodera T, Tomori M, Sakaki K, Enomoto M, HiraiY, Yasutomi Y, Mochizuki H, Uchihara T, Kuwabara S, Mizusawa H, Yokota T.
    • Volume
      135
    • Pages
      833-46
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Journal Article] Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-432012

    • Author(s)
      Uchida A, Sasaguri H, Enomoto M, (18番目), et al
    • Journal Title

      Brain

      Volume: 135 Issue: 3 Pages: 833-46

    • DOI

      10.1093/brain/awr348

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591894, KAKENHI-PROJECT-22240039, KAKENHI-PROJECT-22500325, KAKENHI-PROJECT-22890051, KAKENHI-PUBLICLY-23110505, KAKENHI-PROJECT-23591269, KAKENHI-PROJECT-23591753
  • [Journal Article] Can regional spreading of amyotrophic lateral sclerosis motor symptoms beexplained by prion-like propagation?2012

    • Author(s)
      Kanouchi T, Ohkubo T, Yokota T
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: vol. 83, No. 7 Issue: 7 Pages: 739-745

    • DOI

      10.1136/jnnp-2011-301826

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240039, KAKENHI-PROJECT-24659425, KAKENHI-PROJECT-24689039
  • [Journal Article] Canregional spreading of ALS motor symptoms be explained by prion-like propagation2012

    • Author(s)
      Kanouchi T, Ohkubo T, Yokota T.
    • Journal Title

      J Neurol Neurosurg Psychiatry

    • Data Source
      KAKENHI-PROJECT-22890051
  • [Journal Article] Can regional spreading of ALS motor symptoms be explained by prion-like propagation?2012

    • Author(s)
      Kanouchi T, Ohkubo T, Yokota T
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Journal Article] Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation?2012

    • Author(s)
      Kanouchi T, Ohkubo T, Yokota T
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 83 Pages: 739-45

    • Data Source
      KAKENHI-PROJECT-24659425
  • [Journal Article] プリオン病とパーキンソン病2011

    • Author(s)
      大久保卓哉、水澤英洋
    • Journal Title

      Frontier in Parkinson Disease

      Volume: 4(4) Pages: 196-200

    • Data Source
      KAKENHI-PROJECT-22890051
  • [Journal Article] プリオン病とパーキンソン病2011

    • Author(s)
      大久保卓哉, 水澤英洋
    • Journal Title

      Frontier in Parkinson Disease

      Volume: 4 Pages: 196-200

    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] 霊長類ALSモデルにおけるTDP-43の拡がり2013

    • Author(s)
      大久保卓哉,田尻美緒,関口輝彦,寺岡静香,木村展之,内原俊記,水澤英洋,横田隆徳
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2013-05-31
    • Data Source
      KAKENHI-PROJECT-24689039
  • [Presentation] 霊長類ALSモデルにおけるTDP-43の拡がり2013

    • Author(s)
      大久保卓哉, 田尻美緒, 関口輝彦, 寺岡静香, 木村展之, 内原俊記, 水澤英洋, 横田隆徳.
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区丸の内)
    • Data Source
      KAKENHI-PROJECT-24689039
  • [Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of TDP-43.2012

    • Author(s)
      Ohkubo T, Sasaguri H, Tajiri M, Kimura N、Ono F, Hirai T, Enomoto M.Uchihara T, Mizusawa H, Yokota T.
    • Organizer
      Society for Neuroscience (SFN) 2012.
    • Place of Presentation
      New Orleans
    • Year and Date
      2012-10-15
    • Data Source
      KAKENHI-PROJECT-24689039
  • [Presentation] Propagation of TDP-43 1n non-human primate model of ALS.2012

    • Author(s)
      Tajiri M, Ohkubo T, Kim ura N, Kawakami C、Teraoka S, Uchihara T, Mizusawa H, Yokota T.
    • Organizer
      Society for Neuroscience (SFN) 2012.
    • Place of Presentation
      New Orleans
    • Year and Date
      2012-10-15
    • Data Source
      KAKENHI-PROJECT-24689039
  • [Presentation] ALS霊長類モデルにおけるTDP-43の拡がり. Propagation of TDP-43 1n non-human primate model of ALS.2012

    • Author(s)
      田尻美緒, 大久保卓哉, 木釘展之, 川上ちひろ, 寺岡静香, 内原俊記, 水澤英洋, 横田隆徳.
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PROJECT-24689039
  • [Presentation] Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-432012

    • Author(s)
      Ohkubo T, Tajiri M, Uchida A, Kimura H, Sasaguri N, Uchihara T, Mizusawa H, Yokota T
    • Organizer
      2012 Annual Meeting of the American Neurological Association (ANA)
    • Place of Presentation
      Boston
    • Year and Date
      2012-10-08
    • Data Source
      KAKENHI-PROJECT-24689039
  • [Presentation] ALS霊長類モデルにおけるTDP-43の拡がりPropagation of TDP-43 in non-human primate model of ALS2012

    • Author(s)
      田尻美緒,大久保卓哉,木村展之,川上ちひろ,寺岡静香,内原俊記,水澤英洋,横田隆徳
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PROJECT-24689039
  • [Presentation] Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43.2012

    • Author(s)
      Ohkubo T, Tajiri M, Uchida A, Kimura H, Sasaguri N, Uchihara T, Mizusawa H, Yokota T.
    • Organizer
      2012 Annual Meeting of the American Neurological Association (ANA)
    • Place of Presentation
      Boston
    • Year and Date
      2012-10-08
    • Data Source
      KAKENHI-PROJECT-24689039
  • [Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of TDP-432012

    • Author(s)
      Ohkubo T, Sasaguri H, Tajiri M, Kimura N, Ono F, Hirai T, Enomoto M, Uchihara T, Mizusawa H, Yokota T
    • Organizer
      Society for Neuroscience (SFN) 2012
    • Place of Presentation
      New Orleans
    • Year and Date
      2012-10-15
    • Data Source
      KAKENHI-PROJECT-24689039
  • [Presentation] Propagation of TDP-43 in non-human primate model of ALS2012

    • Author(s)
      Tajiri M, Ohkubo T, Kimura N, Kawakami C, Teraoka S, Uchihara T, Mizusawa H, Yokota T
    • Organizer
      Society for Neuroscience (SFN) 2012
    • Place of Presentation
      New Orleans
    • Year and Date
      2012-10-15
    • Data Source
      KAKENHI-PROJECT-24689039
  • [Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011

    • Author(s)
      Ohkubo T, Uchida A, Sasaguri H, Kimura N, Tajiri M, Kubodera T, Uchihara T, Mizusawa H, Yokota T
    • Organizer
      The 34^<th> Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] The truncation and phosphorylation of TDP-43 is not prerequisite for motoneuronal degeneration in non-human primate model of amyotrophic lateral sclerosis2011

    • Author(s)
      Tajiri M, Sakaue F, Ohkubo T, Uchida A, Sasaguri H, Kimura N, Mizusawa H, Yokota T
    • Organizer
      The 34^<th> Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] Non-human primate model of ALS with cytoplasmic mislocalization of wild-type TDP-432011

    • Author(s)
      Ohkubo T, Uchida A, Sasaguri H, Kimura N, Tajiri M, Kubodera T, Uchihara T, Mizusawa H, Yokota T.
    • Organizer
      The 34^<th> Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] The truncation and phosphorylation of TDP-43 is not prerequisite for motoneuronal degeneration in non-human primate model of amyotrophic lateral sclerosis2011

    • Author(s)
      Tajiri M, Sakaue F, Ohkubo T, UchidaA, Sasaguri H, Kimura N, Mizusawa H, Yokota T.
    • Organizer
      The 34^<th> Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] 孤発性筋委縮性側索硬化症のラットモデル作製(第2報)2011

    • Author(s)
      大久保卓哉,田尻美緒,須永史子,平井高志,澁谷和幹,金井数明,桑原聡,水澤英洋,横田隆〓.
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] 上肢完全麻痺を示した孤発性筋委縮性側索硬化症における脊髄前角細胞でのTDP-43の細胞内局在2011

    • Author(s)
      佐野達彦,大久保卓哉,上野智美,内田あずさ,内原俊記,水澤英洋,横田隆〓.
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-18
    • Data Source
      KAKENHI-PROJECT-22890051
  • [Presentation] TDP-43過剰発現による孤発性ALSモデルの作製2011

    • Author(s)
      横田隆〓,内田あずさ,笹栗弘貴,田尻美緒,佐野達彦,内原俊記,大久保卓哉,水澤英洋
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-22890051
  • 1.  YOKOTA Takanori (90231688)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 12 results
  • 2.  UCHIHARA Toshiki (10223570)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 15 results
  • 3.  KANOUCHI Tadashi (50345287)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  KIMURA Nobuyuki (80392330)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 5.  ENOMOTO Mitsuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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