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Takahashi Hidenori  高橋 秀典

Researcher Number 90601120
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-4801-3540
Affiliation (Current) 2025: 山口大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help 2024 – 2025: 山口大学, 大学院医学系研究科, 講師
2022 – 2023: 大阪大学, 大学院医学系研究科, 講師
2020 – 2023: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 消化器外科副部長
2016 – 2017: 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 副部長
2016: 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, 副部長
2015: 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), 消化器外科, 副部長
2014 – 2015: 地方独立行政法人大阪府立病院機構大阪府立成人病センター(研究所), その他部局等, その他
Review Section/Research Field
Principal Investigator
Basic Section 55020:Digestive surgery-related / Digestive surgery
Except Principal Investigator
Basic Section 55020:Digestive surgery-related / Digestive surgery / Radiation science
Keywords
Principal Investigator
エクソソーム / 膵癌 / microRNA / micro RNA / 肺転移 / 肝転移 / 治療効果 / マイクロRNA / 治療抵抗性 / 集学的治療 / 効果予測 / 術前化学放射線療法 … More
Except Principal Investigator
… More 膵臓癌 / 癌幹細胞 / 胆道癌 / single cell解析 / desmoplastic reaction / 集学的治療 / 癌周囲環境細胞 / 癌微小環境構成細胞 / 浸潤 / 癌 / 癌関連線維芽細胞 / 肝臓癌 / オルガノイド / 低酸素 / 肝細胞癌 / microRNA / エクソソーム / 放射線治療 / 放射線治療学 / 術前化学放射線療法 / IMRT / がん転移 / VMAT / 高精度放射線治療 / 幹細胞 / 放射線耐性 / 抗癌剤耐性 / 膵癌 / 予後 / c-myc / 外科切除 / 術前治療 / 外科治療 / 化学放射線療法 / 化学療法 Less
  • Research Projects

    (9 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (24 People)
  •  門脈血エクソソーム内microRNAを介した膵癌肝・肺転移の分子メカニズム解明Principal Investigator

    • Principal Investigator
      高橋 秀典
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Yamaguchi University
  •  膵癌の大規模単細胞解析に基づく患者層別化と放射線増感技術による集学的治療の最適化

    • Principal Investigator
      江口 英利
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Osaka University
  •  肝胆膵領域癌の浸潤過程における、周囲環境細胞との相互干渉の解析と制御

    • Principal Investigator
      小林 省吾
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Osaka University
  •  末梢血・門脈血中microRNA解析による臓器別転移機序の解明と個別化治療の開発Principal Investigator

    • Principal Investigator
      高橋 秀典
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Osaka University
  •  Molecular mechanism of metastasis, invasion, and resistance to chemo-/radiotherapy in hepato-biliary and pancreatic malignancies

    • Principal Investigator
      和田 浩志
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Osaka International Cancer Institute
  •  Analyses regarding heterogeneity of resistance for chemo- or chemo-radiation therapy in biliary tract cancer

    • Principal Investigator
      Kobayashi Shogo
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Osaka University
      Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses
  •  The significance of c-myc expression in pancreatic cancer

    • Principal Investigator
      Hirofumi Akita
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Osaka International Cancer Institute
  •  high-precision neoadjuvant chemoradiotherapy for pancreatic cancer

    • Principal Investigator
      Teshima Teruki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      Osaka International Cancer Institute
  •  Clinical significance of the exosome detected in the pancreatic juice in the setting of preoperative chemoradiation therapy for pancreatic adenocarcinomaPrincipal Investigator

    • Principal Investigator
      Takahashi Hidenori
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses

All 2023 2022 2018 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] DUPAN-II normalisation as a biological indicator during preoperative chemoradiation therapy for resectable and borderline resectable pancreatic cancer2023

    • Author(s)
      Hasegawa S, Takahashi H, Akita H, Mukai Y, Mikamori M, Asukai K, Yamada D, Wada H, Fujii Y, Sugase T, Yamamoto M, Takeoka T, Shinno N, Hara H, Kanemura T, Haraguchi N, Nishimura J, Matsuda C, Yasui M, Omori T, Miyata H, Ohue M, Ishikawa O, Sakon M.
    • Journal Title

      BMC Cancer

      Volume: 23 Issue: 1 Pages: 63-63

    • DOI

      10.1186/s12885-023-10512-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K09069
  • [Journal Article] Clinical impact of body composition on postoperative outcomes during neoadjuvant chemoradiation therapy for distal bile duct cancer2022

    • Author(s)
      Fujii W, Wada H, Hasegawa S, Mukai Y, Asukai K, Akita H, Sugase T, Yamamoto M, Takeoka T, Shinno N, Hara H, Kanemura T, Haraguchi N, Nishimura J, Yasui M, Matsuda C, Omori T, Miyata H, Ohue M, Sakon M, Takahashi H
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 16 Issue: 6 Pages: 109-109

    • DOI

      10.3892/mco.2022.2542

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K09069
  • [Journal Article] Prognostic value of functional SMAD4 localization in extrahepatic bile duct cancer2022

    • Author(s)
      Takayama H, Kobayashi S, Gotoh K, Sasaki K, Iwagami Y, Yamada D, Tomimaru Y, Akita H, Asaoka T, Noda T, Wada H, Takahashi H, Tanemura M, Doki Y, Eguchi H.
    • Journal Title

      World J Surg Oncol.

      Volume: 20 Pages: 291-291

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K08774
  • [Journal Article] The POU5F1 gene expression in colorectal cancer: a novel prognostic marker.2018

    • Author(s)
      Miyoshi N, Fujino S, Ohue M, Yasui M, Takahashi Y, Sugimura K, Tomokuni A, Akita H, Kobayashi S, Takahashi H, Omori T, Miyata H, Yano M
    • Journal Title

      Surg Today

      Volume: in press Issue: 7 Pages: 709-715

    • DOI

      10.1007/s00595-018-1644-9

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10203, KAKENHI-PROJECT-17K16542, KAKENHI-PROJECT-17K10572
  • [Journal Article] 治療開始前にリンパ節転移陽性と診断した胆嚢癌に対する治療戦略2018

    • Author(s)
      小林省吾、江口英利、後藤邦仁、和田浩志、友國晃、高橋秀則、秋田裕史、岩上佳史、山田大作、浅岡忠史、野田剛広、大植雅之、矢野雅彦、左近賢人、土岐祐一郎、森正樹
    • Journal Title

      胆と膵

      Volume: 39 Pages: 275-281

    • Data Source
      KAKENHI-PROJECT-15K10202
  • [Journal Article] 18F-fluorodeoxyglucose positron emission tomography/computed tomography for the prediction of survival in patients with advanced esophageal cancer who have undergone neoadjuvant chemotherapy.2018

    • Author(s)
      Yano M, Miyata H, Sugimura K, Motoori M, Omori T, Fujiwara Y, Miyoshi N, Yasui M, Ohue M, Akita H, Tomokuni A, Takahashi H, Kobayashi S, Sakon M
    • Journal Title

      Mol Clin Oncol

      Volume: 8(3) Pages: 434-440

    • DOI

      10.3892/mco.2018.1546

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10203
  • [Journal Article] Laparoscopic hilar lymph node sampling in patients with biliary tract cancers that are rarely associated with nodal metastasis.2018

    • Author(s)
      Kobayashi S, Tomokuni A, Takahashi H, Akita H, Marubashi S, Gotoh K, Yanagimoto Y, Takahashi T, Sugimura K, Miyorhi N, Moon JH, Yasui M, Omori T, Miyata T, Ohue M, Fujiwara Y, Yano M, Sakon M.
    • Journal Title

      Surg Laparosc Endosc Percutan Tech.

      Volume: 28 Issue: 2 Pages: 90-95

    • DOI

      10.1097/sle.0000000000000510

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10202, KAKENHI-PROJECT-15K10203
  • [Journal Article] A retrospective analysis of the clinical effects of neoadjuvant combination therapy with full-dose gemcitabine and radiation therapy in patients with biliary tract cancer.2017

    • Author(s)
      Kobayashi S, Tomokuni A, Gotoh K, Takahashi H, Akita H, Marubashi S, Yamada T, Teshima T, Fukui K, Fujiwara Y, Sakon M.
    • Journal Title

      Eur J Surg Oncol.

      Volume: 43 Issue: 4 Pages: 736-771

    • DOI

      10.1016/j.ejso.2016.12.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10202, KAKENHI-PROJECT-15K10203
  • [Journal Article] Novel intraoperative use of the "Tensipresser" to assess factors predictive of pancreatic fistula after pancreaticoduodenectomy.2017

    • Author(s)
      Mikamori M, Gotoh K, Takahashi H, Akita H, Tomokuni A, Kobayashi S, Ohue M, Fujiwara Y, Yano M, Ishikawa O, Sakon M
    • Journal Title

      Surg Today.

      Volume: 47(10) Issue: 10 Pages: 1201-1207

    • DOI

      10.1007/s00595-017-1509-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10203
  • [Journal Article] Clinical Assessment of Sarcopenia and Changes in Body Composition During Neoadjuvant Chemotherapy for Esophageal Cancer.2017

    • Author(s)
      Miyata H, Sugimura K, Motoori M, Fujiwara Y, Omori T, Yanagimoto Y, Ohue M, Yasui M, Miyoshi N, Tomokuni A, Akita H, Kobayashi S, Takahashi H, Yano M
    • Journal Title

      Anticancer Res.

      Volume: 37(6) Pages: 3053-3059

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10203
  • [Journal Article] 19. Prognostic Significance of Basing Treatment Strategy on the Results of Photodynamic Diagnosis in Advanced Gastric Cancer.2017

    • Author(s)
      Ushimaru Y, Fujiwara Y, Kishi K, Sugimura K, Omori T, Moon JH, Yanagimoto Y, Ohue M, Yasui M, Takahashi H, Kobayashi S, Akita H, Miyoshi N, Tomokuni A, Sakon M, Yano M.
    • Journal Title

      Ann Surg Oncol.

      Volume: 24(4) Issue: 4 Pages: 983-989

    • DOI

      10.1245/s10434-016-5660-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10203
  • [Journal Article] Metastatic mixed acinar-endocrine carcinoma of the pancreas treated with a multidisciplinary approach: a case report2017

    • Author(s)
      Hara T, Fujiwara Y, Takahashi H, Sugimura K, Moon JH, Omori T, Miyoshi N, Tomokuni A, Akita H, Kobayashi S, Yasui M, Miyata H, Ohue M, Sakon M, Tomita Y, Yano M.
    • Journal Title

      Surg Case Rep

      Volume: 3(1) Issue: 1 Pages: 51-51

    • DOI

      10.1186/s40792-017-0326-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10203
  • [Journal Article] FDG-PET predicts treatment efficacy and surgical outcome of pre-operative chemoradiation therapy for resectable and borderline resectable pancreatic cancer.2017

    • Author(s)
      Akita H, Takahashi H, Ohigashi H, Tomokuni A, Kobayashi S, Sugimura K, Miyoshi N, Moon JH, Yasui M, Omori T, Miyata H, Ohue M, Fujiwara Y, Yano M, Ishikawa O, Sakon M.
    • Journal Title

      Eur J Surg Oncol

      Volume: 43(6) Issue: 6 Pages: 1061-1067

    • DOI

      10.1016/j.ejso.2017.03.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10203
  • [Journal Article] 胆道癌に対する術前治療の可能性2017

    • Author(s)
      小林省吾、江口英利、後藤邦仁、和田浩志、友國晃、高橋秀則、秋田裕史、岩上佳史、山田大作、浅岡忠史、野田剛広、大植雅之、矢野雅彦、左近賢人、土岐祐一郎、森正樹
    • Journal Title

      臨床外科

      Volume: 72 Pages: 1440-1445

    • Data Source
      KAKENHI-PROJECT-15K10202
  • [Journal Article] The clinical significance of alpha-fetoprotein mRNAs in patients with hepatocellular carcinoma2016

    • Author(s)
      Kobayashi S, Tomokuni A, Takahashi H, Akita H, Sugimura K, Miyoshi N, Moon JH, Yasui M, Omori T, Ohue M, Fujiwara Y, Yano M, Sakon M.
    • Journal Title

      Gastrointestinal Tumors

      Volume: 3 Issue: 3-4 Pages: 141-152

    • DOI

      10.1159/000455955

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10202, KAKENHI-PROJECT-15K10203
  • [Journal Article] Endoscopic marking clip with an IC tag and receiving antenna to detect localization during laparoscopic surgery.2016

    • Author(s)
      Wada Y., Takahashi H., et al.
    • Journal Title

      Surg.Endosc.

      Volume: Oct 31 Issue: 7 Pages: 3056-3060

    • DOI

      10.1007/s00464-016-5303-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04913, KAKENHI-PROJECT-15K10203
  • [Journal Article] Various sulfated carbohydrate tumor marker candidates identified by focused glycomic analyses.2016

    • Author(s)
      Tanaka-Okamoto M., Takahashi H., et al.
    • Journal Title

      Glycobiology

      Volume: Glycobiology Pages: 400-415

    • DOI

      10.1093/glycob/cww133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04913, KAKENHI-PROJECT-15K06863
  • [Journal Article] Risk factors for vertebral compression fractures in preoperative chemoradiotherapy with gemcitabine for pancreatic cancer.2016

    • Author(s)
      Otani.K., Teshima T., Konishi K., Takahashi H., et al.
    • Journal Title

      Radiotherapy and Oncology

      Volume: 118 Issue: 3 Pages: 424-9

    • DOI

      10.1016/j.radonc.2016.01.006

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H04913
  • [Journal Article] Clinicopathological Features of Surgically-resected Biliary Tract Cancer Following Chemo-radiation Therapy.2016

    • Author(s)
      Kobayashi S, Gotoh K, Takahashi H, Akita H, Marubashi S, Yamada T, Teshima T, Nishiyama K, Yano M, Ohigashi H, Ishikawa O, Sakon M.
    • Journal Title

      Anticancer Res.

      Volume: 36 Pages: 335-42

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10202
  • [Journal Article] Preoperative Gemcitabine-based Chemoradiation Therapy for Borderline Resectable Pancreatic Cancer: Impact of Venous and Arterial Involvement Status on Surgical Outcome and Pattern of Recurrence.2016

    • Author(s)
      Takahashi H., et al.
    • Journal Title

      Ann Surg

      Volume: 264(6) Issue: 6 Pages: 1091-97

    • DOI

      10.1097/sla.0000000000001547

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04913
  • [Journal Article] Histopathological effects of preoperative chemoradiotherapy for pancreatic cancer: An analysis for the impact of radiation and gemcitabine doses.2015

    • Author(s)
      Hirata T., Teshima T., Konishi K., Takahashi H., et al.
    • Journal Title

      Radiotherapy and Oncology

      Volume: 114 Issue: 1 Pages: 122-7

    • DOI

      10.1016/j.radonc.2015.01.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04913
  • [Journal Article] The progress of chemotherapy for advanced pancreatic cancer2015

    • Author(s)
      井岡達也、高橋秀典、手島昭樹、他
    • Journal Title

      Nippon Shokakibyo Gakkai Zasshi

      Volume: 112 Issue: 12 Pages: 2119-2126

    • DOI

      10.11405/nisshoshi.112.2119

    • NAID

      130005112041

    • ISSN
      0446-6586, 1349-7693
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04913
  • [Presentation] 腫瘍栓を伴う肝細胞癌に対する治療戦略2017

    • Author(s)
      小林省吾、友國 晃,秋田裕史,高橋秀典,杉村啓二郎,三吉範克,文正浩、安井昌義,大森 健,宮田博志,大植雅之,藤原義之,矢野雅彦,左近賢人
    • Organizer
      第72回日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-15K10202
  • [Presentation] Survival analysis by preoperative CT-based staging of neoadjuvant fulldose gemcitabine and radiotherapy in patients with biliary tract cancer2017

    • Author(s)
      Shogo Kobayashi, Akira Tomokuni、Hidenori Takahashi、Hirofumi Akita、Yoshitomo Yanagimoto、Yusuke Takahashi、Keijiro Sugimura、Norikatsu Miyoshi、Jeong Ho Moon、Masayoshi Yasui、Takeshi Omori
    • Organizer
      29th JSHBPS
    • Data Source
      KAKENHI-PROJECT-15K10202
  • [Presentation] 切除可能胆道癌に対する術前化学放射線療法に関する検討2016

    • Author(s)
      小林省吾、友國 晃,秋田裕史,高橋秀典,杉村啓二郎,三吉範克,文正浩、安井昌義,大森 健,宮田博志,大植雅之,藤原義之,矢野雅彦,左近賢人
    • Organizer
      第41回日本外科系連合学会・学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-15K10202
  • [Presentation] 胆道癌に対するゲムシタビン併用術前化学放射線療法2016

    • Author(s)
      小林省吾、友国晃、後藤邦仁、高橋秀典、秋田裕史、杉村啓二郎、三吉範克、本告正明、出村公一、大森健、能浦真吾、宮田博志、大植雅之、藤原義之、矢野雅彦、石川治、左近賢人
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2016-04-14
    • Data Source
      KAKENHI-PROJECT-15K10202
  • [Presentation] 胆道癌に対する術前化学放射線療法の開発2016

    • Author(s)
      小林省吾、友國晃、高橋秀典、秋田裕史、杉村啓二郎、三吉範克、文正浩、安井昌義、大森健、宮田博志、大植雅之、藤原義之、矢野雅彦、左近賢人
    • Organizer
      第52回胆道学会学術集会
    • Place of Presentation
      横浜市
    • Year and Date
      2016-09-29
    • Data Source
      KAKENHI-PROJECT-15K10202
  • [Presentation] 非切除胆道癌に対する 化学放射線療法後の 胆道癌切除例の検討2016

    • Author(s)
      小林省吾、友國 晃,秋田裕史,高橋秀典,杉村啓二郎,三吉範克,文正浩、安井昌義,大森 健,宮田博志, 大植雅之,藤原義之,矢野雅彦,左近賢人
    • Organizer
      第78回日本臨床外科学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2016-10-24
    • Data Source
      KAKENHI-PROJECT-15K10202
  • 1.  Kobayashi Shogo (30452436)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 20 results
  • 2.  Hirofumi Akita (70528463)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 19 results
  • 3.  冨田 裕彦 (60263266)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  山田 大作 (60571396)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 5.  Teshima Teruki (40136049)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 6.  井岡 達也 (70501815)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  後藤 邦仁 (10362716)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 7 results
  • 8.  和田 浩志 (00572554)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
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  • 23.  江口 英利 (90542118)
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