SASAKI Daisuke 佐々木大介

Researcher Number	90624784
Affiliation (Current)	2025: 長崎大学, 病院(医学系), 技術職員
Affiliation (based on the past Project Information) *help	2014 – 2024: 長崎大学, 病院(医学系), 技術職員 2013: 長崎大学, 大学病院, 臨床検査技師
Review Section/Research Field	Principal Investigator Laboratory medicine Except Principal Investigator Basic Section 52010:General internal medicine-related / Laboratory medicine
Keywords	Principal Investigator HTLV-1 / miRNA / ATL / エクソソーム / exosome / EZH2 Except Principal Investigator HTLV-1 / ATL / 遺伝子検査 / 組み込み部位 … More / 組込み部位 / 成人T 細胞白血病 / 成人T細胞白血病 / クロナリティ検査 / 発症クローン / 成人T細胞白血病・リンパ腫（ATL） / バイオマーカー / 遺伝子発現解析 / 表面抗原 / 分子標的 / 細胞株 Less

Establishment of a new test method detecting HTLV-1 clonality for capture the onset of ATL
- Principal Investigator
  
  長谷川寛雄
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Nagasaki University
Establishment of individualized test method for HTLV-1 carriers based on identification and analysis of ATL-onset clones
- Principal Investigator
  
  HASEGAWA Hiroo
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Nagasaki University
Exploration new biomarkers based on HTLV-1 carrier clone analysis
- Principal Investigator
  
  HASEGAWA Hiroo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagasaki University
Functional analysis and clinical application of tumor-derived exosomes in adult T-cell LeukemiaPrincipal Investigator
- Principal Investigator
  
  SASAKI Daisuke
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagasaki University
Expression analysis of miRNAs regulated by EZH2 in adult T-cell leukemiaPrincipal Investigator
- Principal Investigator
  
  SASAKI Daisuke
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagasaki University

All 2023 2022 2021 2020 2019 2018 2017 2016 2013

All Journal Article Presentation

[Journal Article] Performance evaluation of Espline HTLV-I/II, a newly developed rapid immunochromatographic antibody test for different diagnostic situations2023
- Author(s)
  Kuramitsu M, Momose H, Uchida Y, Ishitsuka K, Kubota R, Tokunaga M, Utsunomiya A, Umekita K, Hashikura Y, Nosaka K, Koh K-R, Nakamura H, Sagara Y, Sobata R, Satake M, Nagata K, Hasegawa Y, Sasaki D, Hasegawa H, Sato T, Yamano Y, Hiraga K, Tezuka K, Ikebe E, Matsuoka S, Okuma K, Watanabe T, Miura K, Hamaguchi I.
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11 Issue: 6 Pages: 1-10
- DOI
  10.1128/spectrum.02078-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15312, KAKENHI-PROJECT-21K09497, KAKENHI-PROJECT-22K08594, KAKENHI-PROJECT-22K09622, KAKENHI-PROJECT-23K06954, KAKENHI-PROJECT-23K24233, KAKENHI-PROJECT-23K24248, KAKENHI-PROJECT-23K24380
[Journal Article] TAS‐116 (pimitespib), a heat shock protein 90 inhibitor, shows efficacy in preclinical models of adult T‐cell leukemia2021
- Author(s)
  Ikebe Emi、Shimosaki Shunsuke、Hasegawa Hiroo、Iha Hidekatsu、Tsukamoto Yoshiyuki、Wang Yu、Sasaki Daisuke、Imaizumi Yoshitaka、Miyazaki Yasushi、Yanagihara Katsunori、Hamaguchi Isao、Morishita Kazuhiro
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 2 Pages: 684-696
- DOI
  10.1111/cas.15204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-20K17390, KAKENHI-PROJECT-23K21375
[Journal Article] Tocilizumab has no direct effect on cell lines infected with human T-cell　leukemia virus type 1.2021
- Author(s)
  Endo Y, Fukui S, Koga T, Sasaki D, Hasegawa H, Yanagihara K, Okayama A, Nakamura T, Kawakami A, Nakamura H. Tocilizumab has no direct effect on cell lines infected with human T-cell　leukemia virus type 1.
- Journal Title
  
  J Int Med Res.
  
  Volume: 49 Issue: 3 Pages: 1-10
- DOI
  10.1177/03000605211002083
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08884, KAKENHI-PROJECT-19K08886, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-19K17888
[Journal Article] A Methodology for Assessing Tumor Clonality of Adult T Cell Leukemia/Lymphoma2020
- Author(s)
  Yamakawa T, Uno N, Sasaki D, Kaku N, Sakamoto K, Kosai K, Hasegawa H, Miyazaki Y, Yanagihara K.
- Journal Title
  
  Mol Ther Methods Clin Dev.
  
  Volume: 19 Pages: 463-473
- DOI
  10.1016/j.omtm.2020.10.015
- NAID
  120006980751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08842, KAKENHI-PROJECT-18H02733
[Journal Article] A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo2020
- Author(s)
  Saito M, Hasegawa H, Yamauchi S, Nakagawa S, Sasaki D, Nao N, Tanio M, Wada Y, Matsudaira T, Momose H, Kuramitsu M, Yamagishi M, Nakashima M, Nakahata S, Iha H, Ogata M, Imaizumi Y, Uchimaru K, Morishita K, Watanabe T, Miyazaki Y, Yanagihara K.
- Journal Title
  
  Int J Hematol.
  
  Volume: 112 Issue: 3 Pages: 300-306
- DOI
  10.1007/s12185-020-02935-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08868, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-17H03594, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-18K08317, KAKENHI-PROJECT-19K16580, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277
[Journal Article] HTLV-1 targets human placental trophoblasts in seropositive pregnant women2020
- Author(s)
  Tezuka Kenta、Fuchi Naoki、Okuma Kazu、Tsukiyama Takashi、Miura Shoko、Hasegawa Yuri、Nagata Ai、Komatsu Nahoko、Hasegawa Hiroo、Sasaki Daisuke、Sasaki Eita、Mizukami Takuo、Kuramitsu Madoka、Matsuoka Sahoko、Yanagihara Katsunori、Miura Kiyonori、Hamaguchi Isao
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 130 Issue: 11 Pages: 6171-6186
- DOI
  10.1172/jci135525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09265, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-18K16805, KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-18K08378
[Journal Article] Exploring the microbiota of upper respiratory tract during the development of pneumonia in a mouse model2019
- Author(s)
  Morinaga Y, Take Y, Sasaki D, Ota K, Kaku N, Uno N, Sakamoto K, Kosai K, Miyazaki T, Hasegawa H, Izumikawa K, Mukae H, Yanagihara K
- Journal Title
  
  PLoS One
  
  Volume: 14(9) Issue: 9 Pages: e0222589-e0222589
- DOI
  10.1371/journal.pone.0222589
- NAID
  120006988400
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02733
[Journal Article] Development of reference material with assigned value for human T-cell leukemia virus type 1 quantitative PCR in Japan2018
- Author(s)
  Kuramitsu M、Okuma K、Nakashima M、Sato T、Sasaki D、Hasegawa H、Umeki K、Kubota R、Sasada K、Sobata R、Matsumoto C、Kaneko N、Tezuka K、Matsuoka S、Utsunomiya A、Koh KR、Ogata M、Ishitsuka K、Taki M、Nosaka K、Uchimaru K、Iwanaga M、Sagara Y、Yamano Y、Okayama A、Miura K et al
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 62 Issue: 10 Pages: 673-676
- DOI
  10.1111/1348-0421.12644
- NAID
  40021702629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-16H05248, KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16H05823, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-16K09702, KAKENHI-PROJECT-16H06277
[Journal Article] Natural course of HTLV-1 proviral DNA levels in carriers during pregnancy2018
- Author(s)
  Fuchi N, Miura K, Tsukiyama T, Sasaki D, Ishihara K, Tsuruda K, Hasegawa H, Miura S, Yanagihara K, Masuzaki H
- Journal Title
  
  Journal of Infectious Diseases
  
  Volume: 217 Issue: 9 Pages: 1383-1389
- DOI
  10.1093/infdis/jiy017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-16K20198, KAKENHI-PROJECT-17K11283, KAKENHI-PROJECT-18K09265, KAKENHI-PROJECT-18K16805, KAKENHI-PROJECT-18H02733
[Journal Article] Proviral features of human T cell leukemia virus type 1 in carriers with indeterminate western blot analysis results.2017
- Author(s)
  Kuramitsu M, Sekizuka T, Yamochi T, Firouzi S, Sato T, Umeki K, Sasaki D, Hasegawa H, Kubota R, Sobata R, Matsumoto C, Kaneko N, Momose H, Araki K, Saito M, Nosaka K, Utsunomiya A, Koh K, Ogata M, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, et al.
- Journal Title
  
  J Clin Microbiol.
  
  Volume: 55(9) Issue: 9 Pages: 2838-2849
- DOI
  10.1128/jcm.00659-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09702, KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-17K15044, KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16H05823, KAKENHI-PROJECT-17H03594, KAKENHI-PROJECT-15K08647, KAKENHI-PROJECT-15K09462, KAKENHI-PROJECT-15K14388, KAKENHI-PROJECT-16H06277
[Journal Article] Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma is associated with activation of Bim and NLRP3.2016
- Author(s)
  Hasegawa H, Bissonnette RP, Gillings M, Sasaki D, Taniguchi H, Kitanosono H, Tsuruda K, Kosai K, Uno N, Morinaga Y, Imaizumi Y, Miyazaki Y, Yanagihara K.
- Journal Title
  
  Cancer Sci
  
  Volume: 107 Issue: 8 Pages: 1124-33
- DOI
  10.1111/cas.12971
- NAID
  120006987664
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08647
[Presentation] 長崎県HTLV-1母子感染防止事業の結果解析2023
- Author(s)
  加勢田富士子, 小佐井康介, 柳原克紀, 吉田麻衣子, 臼井哲也, 佐々木大介, 長谷川寛雄, 三浦清徳
- Organizer
  第38回日本環境感染学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] RAISING法によるHTLV-1クロナリティ解析の評価2023
- Author(s)
  松本成良, 佐々木大介, 長谷川寛雄, 小佐井康介, 加勢田富士子, 太田賢治, 柳原克紀
- Organizer
  第70回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] HTLV-1クロナリティのRAISING法による追跡調査2023
- Author(s)
  松本成良, 佐々木大介, 山内俊輔, 斎藤益満, 加藤丈晴, 今泉芳孝, 長谷川寛雄, 宮﨑泰司, 栁原克紀
- Organizer
  第9回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] Hsp90阻害剤TAS-116 (pimitespib)のATL前臨床試験評価における有効性2022
- Author(s)
  伊波英克, 池辺詠美, 下崎俊介, 長谷川寛雄, 塚本善之, Yu Wang, 佐々木大介, 今泉芳孝, 宮﨑泰司, 柳原克紀, 森下和弘
- Organizer
  第8回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] RAISING法によるHTLV-1クロナリティ解析の評価2022
- Author(s)
  松本成良, 長谷川寛雄, 斎藤益満,佐々木大介, 山内俊輔, 今泉芳孝, 宮﨑泰司, 栁原克紀
- Organizer
  第8回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24233
[Presentation] 新規 HTLV-1 クロナリティ解析法（RAISING 法）による ATL の病態解析2021
- Author(s)
  松本成良、斎藤益満、佐々木大介、山内俊輔、今泉芳孝、長谷川寛雄、宮﨑泰司、栁原克紀
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 成人T細胞白血病/リンパ腫のクローン構成を評価する新規方法の開発2021
- Author(s)
  山川智弘, 佐々木大介, 太田賢治, 加勢田富士子, 長谷川寛雄, 柳原克紀
- Organizer
  第68回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 寛解 17 年後に再発した成人 T 細胞白血病・リンパ腫2021
- Author(s)
  西村紗央里、加藤丈晴、村山直也、佐藤信也、安東恒史、松本成良、佐々木大介、澤山靖、三好寛明、今泉芳孝、長谷川寛雄、柳原克紀、大島孝一、宮﨑泰司
- Organizer
  第7回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 次世代HTLV-1クロナリティ解析法(RAIS1)の開発2020
- Author(s)
  山内俊輔、斎藤益満,、長谷川寛雄、佐々木大介、渕上麻衣、森沙耶香、鶴田一人、今泉芳孝、宮崎泰司、柳原克紀
- Organizer
  日本検査血液学会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] HTLV-1キャリアに対する血漿miRNAを用いたATL発症スクリーニング検査の確立2020
- Author(s)
  新野大介、佐々木大介、山内俊介、長谷川寛雄、柳原克紀、岩永正子
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 次世代HTLV-1 クロナリティ解析法(RAIS1)の開発とその進捗2019
- Author(s)
  山内俊輔、長谷川寛雄、斎藤益満、佐々木大介、今泉芳孝、柳原克紀
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] ランダムインテグレーション評価法（RAIS2）の開発と検査・解析サービスの展開2019
- Author(s)
  斎藤益満、長谷川寛雄、佐々木大介、山内俊輔、和田悠作、松平崇弘
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] キャリア妊婦におけるHTLV-1 経胎盤感染の実態解明の試み2019
- Author(s)
  手塚健太、淵直樹、大隈和、築山尚史、長谷川ゆり、長谷川寛雄、佐々木大介、三浦生子、東島愛、佐々木永太、水上拓郎、倉光球、松岡佐保子、増﨑英明、三浦清徳、浜口功
- Organizer
  第6回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 次世代HTLV-1クロナリティ解析法の開発2018
- Author(s)
  山内俊輔、斎藤益満、長谷川寛雄、佐々木大介、賀来敬仁、宇野直輝、森永芳智、今泉芳孝、宮﨑泰司、栁原克紀
- Organizer
  第65回日本臨床検査医学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 次世代HTLV-1 クロナリティ解析法の開発とその応用に向けて2018
- Author(s)
  斎藤益満、山内俊輔、佐々木大介、長谷川寛雄
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-18H02733
[Presentation] 2.妊婦スクリーニング検体のHTLV-1定量検査におけるデジタルPCR法とリアルタイムPCR法の比較2017
- Author(s)
  淵直樹，三浦清徳，佐々木大介，鶴田一人，長谷川寛雄，栁原克紀，増崎英明
- Organizer
  第4回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08647
[Presentation] 1.臨床検体のHTLV-1定量検査におけるデジタルPCR法とリアルタイムPCR法の比較2017
- Author(s)
  佐々木大介，長谷川寛雄，淵直樹，三浦清徳，上野友郁，吉田彩香，松本成良，山川嘉美，賀来敬仁，小佐井康介，宇野直輝，増崎英明，栁原克紀
- Organizer
  第4回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-15K08647
[Presentation] EZH2 Inhibitor DZNep Induces Apoptosis In Adult T-Cell Leukemia/Lymphoma Cells By BCL2 Suppression Via Regulation Of Mir-181a2013
- Author(s)
  Sasaki D
- Organizer
  55th ASH Annual Meeting and Exposition
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-25860411
[Presentation] EZH2 inhibitor DZNep suppress BCL2 expression and induce apoptosis in ATL cells.2013
- Author(s)
  佐々木　大介
- Organizer
  第72回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Data Source
  KAKENHI-PROJECT-25860411

1. HASEGAWA Hiroo (00398166)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
2. 柳原克紀 (40315239)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
3. 今泉芳孝 (40404305)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
4. 斎藤益満 (20571045)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. 波多智子 (10346968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 宮崎泰司 (40304943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. MIURA Kiyonori

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
8. NAKAMURA Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. SATO Tomoo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. MIURA Shoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 坂本啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 池辺詠美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 川上純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SASAKI Daisuke 佐々木 大介

Research Projects

Research Products

Co-Researchers

Establishment of a new test method detecting HTLV-1 clonality for capture the onset of ATL

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of individualized test method for HTLV-1 carriers based on identification and analysis of ATL-onset clones

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration new biomarkers based on HTLV-1 carrier clone analysis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis and clinical application of tumor-derived exosomes in adult T-cell LeukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression analysis of miRNAs regulated by EZH2 in adult T-cell leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Performance evaluation of Espline HTLV-I/II, a newly developed rapid immunochromatographic antibody test for different diagnostic situations2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TAS‐116 (pimitespib), a heat shock protein 90 inhibitor, shows efficacy in preclinical models of adult T‐cell leukemia2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tocilizumab has no direct effect on cell lines infected with human T-cell leukemia virus type 1.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Methodology for Assessing Tumor Clonality of Adult T Cell Leukemia/Lymphoma2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] A high-throughput detection method for the clonality of Human T-cell leukemia virus type-1-infected cells in vivo2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HTLV-1 targets human placental trophoblasts in seropositive pregnant women2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exploring the microbiota of upper respiratory tract during the development of pneumonia in a mouse model2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Development of reference material with assigned value for human T-cell leukemia virus type 1 quantitative PCR in Japan2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Natural course of HTLV-1 proviral DNA levels in carriers during pregnancy2018

Author(s)

Journal Title

SASAKI Daisuke 佐々木大介

[Journal Article] Tocilizumab has no direct effect on cell lines infected with human T-cell　leukemia virus type 1.2021