UEDA YUKI 上田優輝

… Alternative Names

Ueda Youki 上田優輝

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Researcher Number	90756074
Other IDs	https://orcid.org/0000-0002-2627-8524
Affiliation (Current)	2026: 岡山大学, 医歯薬学域, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 岡山大学, 医歯薬学域, 助教 2016 – 2019: 岡山大学, 医歯薬学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / Basic Section 53010:Gastroenterology-related Except Principal Investigator Virology
Keywords	Principal Investigator ミトコンドリア異常 / 抗腫瘍免疫応答 / マウスモデル / T細胞 / 異常ミトコンドリア / mtDNA / シングルセル解析 / 肝細胞がん / MASLD / 変異動態 … More / RNAウイルス / 長期複製 / ゲノム / 数理モデル / 長期継代 / 数理化モデル / C型肝炎ウイルス / HCV / 新規抗HBV剤候補 / 新規宿主因子 / サブクローン化細胞株 / HBV / HBV/secNL repoter assay / Subcloning / NTCP / Li23 / Rosiglitazone / Cyclosporin A / B型肝炎ウイルス / 薬剤感受性 / cGAS,STING経路 / HepG2/NTCP細胞 / A8.15.78.10細胞 / サブクローニング / Li23/NTCP細胞 / B型肝炎ウイルス(HBV) … More Except Principal Investigator 長期HBV複製細胞 / C型肝炎ウイルス / 癌 / 感染症 / 発現制御 / 遺伝子 / ウイルス / HBV長期複製細胞 / HCV長期複製細胞 / B型肝炎ウイルス(HBV) / C型肝炎ウイルス(HCV) / Exosome / HBV感受性 / 遺伝子発現変動 / 長期HCV複製細胞 / B型肝炎ウイルス / C 型肝炎ウイルス Less

MASLD関連肝細胞がんにおけるミトコンドリア異常の抗腫瘍免疫応答への影響の解明Principal Investigator
- Principal Investigator
  
  上田優輝
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Okayama University
Mathematical modeling of HCV-based RNA virus mutation dynamicsPrincipal Investigator
- Principal Investigator
  
  Ueda Youki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Okayama University
Establishment of HBV-sensitive human hepatocyte lines and analysis of HBV essential factorsPrincipal Investigator
- Principal Investigator
  
  Ueda Youki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Okayama University
Research on the mechanism of hepatocarcinogenesis by long-term replication of hepatitis virus
- Principal Investigator
  
  Kato Nobuyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Okayama University

All 2025 2024 2023 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] High Antigenicity for Treg Cells Confers Resistance to PD-1 Blockade Therapy via High PD-1 Expression in Treg Cells2025
- Author(s)
  Matsuura Hiroaki、Ishino Takamasa、Ninomiya Toshifumi、Ninomiya Kiichiro、Tachibana Kota、Honobe‐Tabuchi Akiko、Muto Yoshinori、Inozume Takashi、Ueda Youki、Ohashi Kadoaki、Maeda Yoshinobu、Nagasaki Joji、Togashi Yosuke
- Journal Title
  
  Cancer Science
  
  Volume: 116 Issue: 5 Pages: 1214-1226
- DOI
  10.1111/cas.70029
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15607, KAKENHI-PROJECT-23K24339, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-24K18933, KAKENHI-PROJECT-23KK0149
[Journal Article] Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy2025
- Author(s)
  Ninomiya Toshifumi、Kemmotsu Naoya、Mukohara Fumiaki、Magari Masaki、Miyamoto Ai、Ueda Youki、Ishino Takamasa、Nagasaki Joji、Fujiwara Tomohiro、Yamamoto Hidetaka、Hayashi Hidetoshi、Tachibana Kota、Ishida Joji、Otani Yoshihiro、Tanaka Shota、Toyooka Shinichi、Okamoto Isamu、Togashi Yosuke
- Journal Title
  
  Cancer Research
  
  Volume: 85 Issue: 6 Pages: 1082-1096
- DOI
  10.1158/0008-5472.can-24-2274
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-24K18933, KAKENHI-PROJECT-23KK0149
[Journal Article] Immune evasion through mitochondrial transfer in the tumour microenvironment2025
- Author(s)
  Ikeda H, Kawase K, Nishi T, Watanabe T, Takenaga K, Inozume T, Ishino T, Aki S, Lin J, Kawashima S, Togashi Y, et al
- Journal Title
  
  Nature
  
  Volume: 638 Issue: 8049 Pages: 225-236
- DOI
  10.1038/s41586-024-08439-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-23K18234, KAKENHI-PROJECT-22KJ0489, KAKENHI-PROJECT-23K24337, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-23K07303, KAKENHI-PROJECT-24K10137, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-24K18933, KAKENHI-PROJECT-23KK0149
[Journal Article] Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment2024
- Author(s)
  Zhou Wenhao、Kawashima Shusuke、Ishino Takamasa、Kawase Katsushige、Ueda Youki、Yamashita Kazuo、Watanabe Tomofumi、Kawazu Masahito、Dansako Hiromichi、Suzuki Yutaka、Nishikawa Hiroyoshi、Inozume Takashi、Nagasaki Joji、Togashi Yosuke
- Journal Title
  
  Cell Reports
  
  Volume: 43 Issue: 2 Pages: 113797-113797
- DOI
  10.1016/j.celrep.2024.113797
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23KK0149, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K15472, KAKENHI-PROJECT-22K20824, KAKENHI-PROJECT-22H00455, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-23K14594, KAKENHI-PROJECT-23K15261
[Journal Article] Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity2024
- Author(s)
  Mukohara F、Iwata K、Ishino T、Inozume T、Nagasaki J、Ueda Y、Suzawa K、Ueno T、Ikeda H、Kawase K、Saeki Y、Kawashima S、Yamashita K、Kawahara Y、Nakamura Y、Honobe-Tabuchi A、Watanabe H、Dansako H、Kawamura T、Suzuki Y、Honda H、Mano H、Toyooka S、Kawazu M、Togashi Y
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 121 Issue: 35
- DOI
  10.1073/pnas.2320189121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12117, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-23K15261, KAKENHI-PROJECT-22KJ0489, KAKENHI-PROJECT-23K27442, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K11468, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-24K18933, KAKENHI-PROJECT-23KK0149
[Journal Article] CD106 in tumor-specific exhausted CD8+ T cells mediates immunosuppression by inhibiting TCR signaling2024
- Author(s)
  Naoi Y, Morinaga T, Nagasaki J, Ariyasu R, Ueda Y, Yamashita K, Zhou W, Kawashima S, Kawase K, Honobe-Tabuchi A, Ohnuma T, Kawamura T, Umeda Y, Kawahara Y, Nakamura Y, Kiniwa Y, Yamasaki O, Fukushima S, Kawazu M, Suzuki Y, Nishikawa H, Hanazawa T, Ando M, Inozume T, Togashi Y.
- Journal Title
  
  Cancer Research
  
  Volume: - Issue: 13 Pages: 2109-2122
- DOI
  10.1158/0008-5472.can-23-0453
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14594, KAKENHI-PROJECT-23K07765, KAKENHI-PROJECT-21K08314, KAKENHI-PROJECT-22K08424, KAKENHI-PROJECT-23K15261, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K11468, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-23KK0149
[Journal Article] Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling2024
- Author(s)
  Nakajima Takahiro、Kanno Toshio、Ueda Yuki、Miyako Keisuke、Endo Takeru、Yoshida Souta、Yokoyama Satoru、Asou Hikari K.、Yamada Kazuko、Ikeda Kazutaka、Togashi Yosuke、Endo Yusuke
- Journal Title
  
  Cellular & Molecular Immunology
  
  Volume: 21 Issue: 11 Pages: 1266-1281
- DOI
  10.1038/s41423-024-01209-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-23H04794, KAKENHI-PROJECT-23K14552, KAKENHI-PROJECT-24K02246, KAKENHI-PROJECT-24K02459, KAKENHI-PROJECT-24K11153, KAKENHI-PROJECT-24K22064, KAKENHI-PROJECT-24K22071, KAKENHI-PROJECT-23KK0149
[Journal Article] Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens2023
- Author(s)
  Ishino Takamasa、Kawashima Shusuke、Tanji Etsuko、Ueno Toshihide、Ueda Youki、Ogasawara Sadahisa、Sato Kazuhito、Mano Hiroyuki、Ishihara Soichiro、Kato Naoya、Kawazu Masahito、Togashi Yosuke
- Journal Title
  
  British Journal of Cancer
  
  Volume: 128 Issue: 6 Pages: 1166-1175
- DOI
  10.1038/s41416-023-02165-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08049, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K15472, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21H02772, KAKENHI-PROJECT-21K20859, KAKENHI-PROJECT-21K12117
[Journal Article] Activated CTLA‐4‐independent immunosuppression of Treg cells disturbs CTLA‐4 blockade‐mediated antitumor immunity2023
- Author(s)
  Watanabe T、Ishino T、Ueda Y、Nagasaki J、Sadahira T、Dansako H、Araki M、Togashi Y
- Journal Title
  
  Cancer Science
  
  Volume: In press Issue: 5 Pages: 1859-1870
- DOI
  10.1111/cas.15756
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-20H03694, KAKENHI-PROJECT-21K20859, KAKENHI-PROJECT-22K15472
[Journal Article] Low frequency of intracranial progression in advanced NSCLC patients treated with cancer immunotherapies2023
- Author(s)
  Kemmotsu N , Ninomiya K , Kunimasa K , IshinoT ,Nagasaki J , Otani Y , Michiue H ,Ichihara E ,Ohashi K ,Inoue T ,Tamiya M ,Sakai K ,Ueda Y , Dansako H ,Nishio K ,Kiura K , Date I ,Togashi Y
- Journal Title
  
  International Journal of Cancer
  
  Volume: 154(1) Issue: 1 Pages: 169-179
- DOI
  10.1002/ijc.34700
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16687, KAKENHI-PROJECT-21K09176, KAKENHI-PROJECT-22K19459, KAKENHI-PROJECT-22K19529, KAKENHI-PROJECT-22K15472, KAKENHI-PROJECT-23K24339
[Journal Article] Combination therapy with hydrogen peroxide and irradiation promotes an abscopal effect in mouse models2023
- Author(s)
  Kemmotsu N , Zhu L , Nagasaki J , Otani Y , Ueda Y , Dansako H , Fang Y , Date I , Togashi Y
- Journal Title
  
  Cancer Science
  
  Volume: 114(10) Issue: 10 Pages: 3848-3856
- DOI
  10.1111/cas.15911
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16687, KAKENHI-PROJECT-22K15472
[Journal Article] Study of Multiple Genetic Variations Caused by Persistent Hepatitis C Virus Replication in Long-Term Cell Culture2020
- Author(s)
  Nobuyuki Kato, Youki Ueda, Hiroe Sejima, Weilin Gu, Shinya Satoh, Hiromichi Dansako, Masanori Ikeda, Kunitada Shimotohno
- Journal Title
  
  Archives of Virology
  
  Volume: 165 Issue: 2 Pages: 331-343
- DOI
  10.1007/s00705-019-04461-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15169
[Journal Article] A new hepatoma cell line exhibiting high susceptibility to hepatitis B virus infection2019
- Author(s)
  Ueda Youki、Gu Weilin、Dansako Hiromichi、Nishitsuji Hironori、Satoh Shinya、Shimotohno Kunitada、Kato Nobuyuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 515 Issue: 1 Pages: 156-162
- DOI
  10.1016/j.bbrc.2019.05.126
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07161, KAKENHI-PROJECT-18K15169
[Journal Article] High‐level expression of STING restricts susceptibility to HBV by mediating type III IFN induction.2019
- Author(s)
  Dansako H, Imai H, Ueda Y, Satoh S, Shimotohno K, Kato N.
- Journal Title
  
  FASEB BioAdvances
  
  Volume: 1 Pages: 67-80
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05196
[Journal Article] High-level expression of STING restricts susceptibility to HBV by mediating type III IFN induction2018
- Author(s)
  Dansako Hiromichi、Imai Hirotaka、Ueda Youki、Satoh Shinya、Shimotohno Kunitada、Kato Nobuyuki
- Journal Title
  
  FASEB BioAdvances
  
  Volume: 1 Issue: 2 Pages: 67-80
- DOI
  10.1096/fba.1022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15169
[Journal Article] Ribavirin-induced down-regulation of CCAAT/enhancer-binding protein α leads to suppression of lipogenesis2018
- Author(s)
  Satoh Shinya、Onomura Daichi、Ueda Youki、Dansako Hiromichi、Honda Masao、Kaneko Shuichi、Kato Nobuyuki
- Journal Title
  
  Biochemical Journal
  
  Volume: 476 Issue: 1 Pages: 137-149
- DOI
  10.1042/bcj20180680
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07972, KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-26253046, KAKENHI-PROJECT-16H05196, KAKENHI-PROJECT-18K15169
[Journal Article] Multiple antiviral activities of the antimalarial and anti-hepatitis C drug candidates N-89 and N-2512018
- Author(s)
  Ueda Youki、Gu Weilin、Dansako Hiromichi、Kim Hye-Sook、Yoshizaki Sayaka、Okumura Nobuaki、Ishikawa Tomohiro、Nishitsuji Hironori、Kato Fumihiro、Hishiki Takayuki、Satoh Shinya、Ishii Koji、Masuda Michiaki、Shimotohno Kunitada、Ikeda Masanori、Kato Nobuyuki
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 15 Pages: 1-6
- DOI
  10.1016/j.bbrep.2018.05.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08870, KAKENHI-PROJECT-18K15169, KAKENHI-PROJECT-16H05196, KAKENHI-PROJECT-16K08825, KAKENHI-PROJECT-18K07086
[Journal Article] ULBP1 is induced by hepatitis C virus infection and is the target of the NK cell-mediated innate immune response in human hepatocytes2018
- Author(s)
  Dansako Hiromichi、Imai Hirotaka、Ueda Youki、Satoh Shinya、Wakita Takaji、Kato Nobuyuki
- Journal Title
  
  FEBS Open Bio
  
  Volume: 8 Issue: 3 Pages: 361-371
- DOI
  10.1002/2211-5463.12373
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09447, KAKENHI-PROJECT-16H05196, KAKENHI-PROJECT-15K08498
[Journal Article] Daunorubicin, a topoisomerase II poison, suppresses viral production of hepatitis B virus by inducing cGAS-dependent innate immune response2018
- Author(s)
  Imai Hirotaka、Dansako Hiromichi、Ueda Youki、Satoh Shinya、Kato Nobuyuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 504 Issue: 4 Pages: 672-678
- DOI
  10.1016/j.bbrc.2018.08.195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15169, KAKENHI-PROJECT-16H05196
[Journal Article] Ribavirin suppresses hepatic lipogenesis through inosine monophosphate dehydrogenase inhibition: Involvement of adenosine monophosphate-activated protein kinase-related kinases and retinoid X receptor α.2017
- Author(s)
  S Satoh, K Mori, D Onomura, Y Ueda, H Dansako, M Honda, S Kaneko, M Ikeda, N Kato.
- Journal Title
  
  Hepatol Commun
  
  Volume: 1 Issue: 6 Pages: 550-563
- DOI
  10.1002/hep4.1065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06393, KAKENHI-PROJECT-15H04809, KAKENHI-PROJECT-16H05196
[Journal Article] Evaluation of preclinical antimalarial drugs, which can overcome direct-acting antivirals-resistant hepatitis C viruses, using the viral reporter assay systems.2017
- Author(s)
  Ueda Y, Dansako H, Sato S, Kim HS, Wataya Y, Doi H, Ikeda M, Kato N.
- Journal Title
  
  Virus Res
  
  Volume: 235 Pages: 37-48
- DOI
  10.1016/j.virusres.2017.03.015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05196, KAKENHI-PROJECT-15K15142
[Presentation] A new hepatoma cell line exhibiting high susceptibility to HBV infection.2019
- Author(s)
  Ueda Y, Gu W, Dansako H, Nishitsuji H, Satoh S, Shimotohno K, Kato N.
- Organizer
  The 67th Annual Meeting of The Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] HBV-triggered antiviral signaling is transduced to neighboring cell by mediating extracellular vesicles in human immortalized hepatocyte NKNT-3.2019
- Author(s)
  Dansako H, Imai H, Ueda Y, Satoh S, Kato N.
- Organizer
  The 67th Annual Meeting of The Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] 抗HCV薬リバビリンによるGAPM発現抑制機序の解析2019
- Author(s)
  小野村大地、佐藤伸哉、團迫浩方、上田優輝、加藤宣之
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] HBV高感受性新規肝がん細胞株の樹立2019
- Author(s)
  上田優輝、Gu Weilin、團迫浩方、西辻裕紀、佐藤伸哉、下遠野邦忠、加藤宣之
- Organizer
  第34回中国四国ウイルス研究会
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] ヒト不死化肝NKNT-3細胞において、細胞外小胞を介する細胞間自然免疫伝達機構の解明2019
- Author(s)
  團迫浩方、今井大誉、上田優輝、佐藤伸哉、加藤宣之
- Organizer
  第34回中国四国ウイルス研究会
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] A new human hepatoma cell line exhibiting high susceptibility to HBV infection.2019
- Author(s)
  Ueda Y, Gu W, Dansako H, Nishitsuji H, Satoh H, Shimotohno K, Kato N.
- Organizer
  The 2019 international HBV meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] 転写因子C/EBPαを標的にした中性脂肪合成阻害剤の探索2019
- Author(s)
  佐藤伸哉、小野村大地、渡士幸一、上田優輝、團迫浩方、本多政夫、金子周一、加藤宣之
- Organizer
  第3回中性脂肪学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] 抗HCV薬リバビリンによるGPAM発現抑制機序の解析2019
- Author(s)
  小野村大地、佐藤伸哉、團迫浩方、上田優輝、加藤宣之
- Organizer
  第3回中性脂肪学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] 抗ウイルス薬リバビリンによる転写因子C/EBPαタンパク質の分解亢進は細胞内中性脂肪量を低下させる2019
- Author(s)
  佐藤伸哉、小野村大地、上田優輝、團迫浩方、本多政夫、金子周一、加藤宣之
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] ヒト不死化肝NKNT-3細胞におけるtopoisomerase II阻害剤によるcGAS依存的な自然免疫応答の誘導2018
- Author(s)
  今井大誉、團迫浩方、上田優輝、佐藤伸哉、加藤宣之
- Organizer
  第33回中国四国ウイルス研究会
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] ヒト不死化肝NKNT-3細胞におけるB型肝炎ウイルスの感染増殖性を制御する宿主因子の探索2018
- Author(s)
  團迫浩方、今井大誉、上田優輝、佐藤伸哉、下遠野邦忠、加藤宣之
- Organizer
  第33回中国四国ウイルス研究会
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] Topoisomerase II inhibitor triggers cyclic GMP-AMP synthase-dependent innate immune response in human immortalized hepatocyte NKNT-32018
- Author(s)
  Hirotaka Imai, Hiromichi Dansako, Youki Ueda, Shinya Satoh, Nobuyuki Kato
- Organizer
  第66回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] Screening of the new host factors necessary for HBV proliferation using plural human cell lines2018
- Author(s)
  Youki Ueda, Hiromichi Dansako, Shinya Satoh, Kunitada Shimotohno, Nobuyuki Kato
- Organizer
  第66回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] Mechanism of GPAM suppression by Anti-HCV drug ribavirin2018
- Author(s)
  Daichi Onomura, Shinya Satoh, Youki Ueda, Hiromichi Dansako, Nobuyuki Kato
- Organizer
  第66回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] Topoisomerase II inhibitor triggers cyclic GMP-AMP synthase-dependent innate immune response in human immortalized hepatocyte NKNT-32018
- Author(s)
  Imai H, Dansako H, Ueda Y, Satoh S, Kato N
- Organizer
  The 66th Annual Meeting of The Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] Analysis of new host factors necessary for susceptibility to HBV using plural human cell lines2018
- Author(s)
  Ueda Y, Dansako H, Satoh H, Shimotohno K, Kato N
- Organizer
  The 2018 international HBV meeting,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] Highly expression of STING restricts HBV infection by mediating the induction of type III interferon in human immortalized hepatocyte NKNT-32018
- Author(s)
  Hiromichi Dansako, Hirotaka Imai, Youki Ueda, Shinya Satoh, Kunitada Shimotohno, Nobuyuki Kato
- Organizer
  第66回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] Analysis of the new host factors necessary for susceptibility to HBV using plural human cell lines2018
- Author(s)
  Youki Ueda, Hiromichi Dansako, Shinya Satoh, Kunitada Shimotohno, Nobuyuki Kato
- Organizer
  2018 International Meeting on Molecular Biology of Hepatitis B Virus
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] HCV以外の広範なウイルスにも有効性を示した抗マラリア薬候補N-89とN-2512018
- Author(s)
  上田優輝、Gu Weilin、團迫浩方、佐藤伸哉、池田正徳、加藤宣之
- Organizer
  第33回中国四国ウイルス研究会
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] 抗マラリア及び抗HCV薬候補N-89とN-251が有する幅広い抗ウイルス活性2018
- Author(s)
  上田優輝, 谷イ琳, 團迫浩方, 金惠淑, 吉崎佐矢香, 奥村暢章, 石川知弘, 西辻裕紀, 加藤文博, 日紫喜隆行, 佐藤伸哉, 石井孝司, 増田道明, 下遠野邦忠, 池田正徳, 加藤宣之
- Organizer
  第28回抗ウイルス療法学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] 抗マラリア及び抗HCV薬候補N-89とN-251が有する幅広い抗ウイルス活性2018
- Author(s)
  上田優輝、Gu Weilin、團迫浩方、金惠淑、吉崎佐矢香、奥村暢章、石川知弘、西辻裕紀、加藤文博、日紫喜隆行、佐藤伸哉、石井孝司、増田道明、下遠野邦忠、池田正徳、加藤宣之
- Organizer
  第28回抗ウイルス療法学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] Highly expression of STING restricts HBV infection by mediating the induction of type III interferon in human immortalized hepatocyte NKNT-32018
- Author(s)
  Dansako H, Imai H, Ueda Y, Satoh S, Shimotohno K, Kato N
- Organizer
  The 66th Annual Meeting of The Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] Analysis of host and viral factors contributing to resistant acquisition for the preclinical anti-HCV drugs, N-89 and N-2512018
- Author(s)
  Weilin Gu, Youki Ueda, Shinya Satoh, Hiromichi Dansako, Nobuyuki Kato
- Organizer
  第66回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] B型肝炎ウイルス感染ヒト不死化肝NKNT-3細胞由来のエクソソーム内タンパク質の解析2018
- Author(s)
  團迫浩方、今井大誉、上田優輝、佐藤伸哉、加藤宣之
- Organizer
  第５回日本細胞外小胞学会
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] Screening of the new host factors necessary for HBV proliferation using plural human cell lines2018
- Author(s)
  Ueda Y, Dansako H, Satoh S, Shimotohno K, Kato N
- Organizer
  The 66th Annual Meeting of The Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-18K15169
[Presentation] Drug screening for suppression of lipogenesis through downregulation of C/EBPα2018
- Author(s)
  Shinya Satoh, Daichi Onomura, Koichi Watashi, Youki Ueda, Hiromichi Dansako, Masao Honda,, Shuichi Kaneko, Nobuyuki Kato
- Organizer
  第66回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] HCVポリメラーゼ/プロテアーゼ二重阻害活性を有するフラーレン誘導体の細胞内HCV複製阻害及び酸化ストレス抑制効果2017
- Author(s)
  片岡　裕樹、上田　優輝、髙橋　恭子、中村　成夫、大江　知之、加藤　宣之、増野　匡彦
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] Identification of new amino acid substitutions contributing to DAA-resistance, using HCV reporter assay systems2017
- Author(s)
  Youki Ueda, Hiromichi Dansako, Shinya Satoh, Masanori Ikeda, Nobuyuki Kato
- Organizer
  第65回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] Downregulation of C/EBPα by anti-HCV drug ribavirin leads to the suppression of triglyceride synthesis pathway2017
- Author(s)
  Shinya Satoh, Daichi Onomura, Youki Ueda, Hiromichi Dansako, Masao Honda, Shuichi Kaneko, Nobuyuki Kato
- Organizer
  第65回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] Development of human hepatoma cell line, Li23-derived cells possessing high susceptibility to HBV2017
- Author(s)
  Youki Ueda, Hiromichi Dansako, Shinya Satoh, Kunitada Shimotohno, Nobuyuki Kato
- Organizer
  2017 International Meeting on Molecular Biology of Hepatitis B Virus
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] Resistant acquisition mechanism for anti-HCV drug candidates, N-89 and its derivative N-2512017
- Author(s)
  Weilin Gu, Youki Ueda, Shinya Satoh, Hiromichi Dansako, Nobuyuki Kato
- Organizer
  第65回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] Development of HBV infection system using human immortalized hepatocyte NKNT-3 cells2017
- Author(s)
  Hiromichi Dansako, Hirotaka Imai, Youki Ueda, Shinya Satoh, Kunitada Shimotohno, Nobuyuki Kato
- Organizer
  第65回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] Genetic characterization of HCVs obtained from HCV-RNA-replicating cells possessing a DAA-, N-89-, or N-251-resistant phenotype.2016
- Author(s)
  Ueda　Y, Dansako H, Satoh S, Ikeda M, Kato N.
- Organizer
  The 64th Annual Meeting of The Japanese Society for Virology
- Place of Presentation
  札幌コンベンションセンター、札幌
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] Both host and viral factors contribute to the resistance to preclinical anti-HCV drugs, N-89 and N-251.2016
- Author(s)
  Gu W, Ueda Y, Dansako H, Satoh S, Kato N.
- Organizer
  The 64th Annual Meeting of The Japanese Society for Virology
- Place of Presentation
  札幌コンベンションセンター、札幌
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-16H05196
[Presentation] DAA製剤によるHCV治療におけるN-89/N-251の有用性とそれらの作用機序の解析2016
- Author(s)
  上田優輝、團迫浩方、佐藤伸哉、池田正徳、加藤宣之
- Organizer
  第26回抗ウイルス療法学会総会
- Place of Presentation
  名古屋市立大学、名古屋
- Year and Date
  2016-05-13
- Data Source
  KAKENHI-PROJECT-16H05196

1. Kato Nobuyuki (40150883)

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
2. 金惠淑 (70314664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 佐藤伸哉 (80333558)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
4. 團迫浩方 (80379841)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
5. 冨樫庸介 (80758326)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 大塚基之 (90518945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SEJIMA Hiroe

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KOKU Irin

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. ONOMURA Daichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. HIRAMOTO Hiroki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HISHIKI Takayuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 小笠原定久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 二宮貴一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 長崎譲慈

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 上野敏秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 本多政夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 金子周一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 西辻裕紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 大谷理浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 脇田隆字

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 遠藤裕介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 渡邊毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 渡辺俊樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

UEDA YUKI 上田 優輝

Ueda Youki 上田 優輝

Research Projects

Research Products

Co-Researchers

MASLD関連肝細胞がんにおけるミトコンドリア異常の抗腫瘍免疫応答への影響の解明Principal Investigator

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Mathematical modeling of HCV-based RNA virus mutation dynamicsPrincipal Investigator

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Establishment of HBV-sensitive human hepatocyte lines and analysis of HBV essential factorsPrincipal Investigator

Principal Investigator

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Research on the mechanism of hepatocarcinogenesis by long-term replication of hepatitis virus

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[Journal Article] High Antigenicity for Treg Cells Confers Resistance to PD-1 Blockade Therapy via High PD-1 Expression in Treg Cells2025

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[Journal Article] Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy2025

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[Journal Article] Immune evasion through mitochondrial transfer in the tumour microenvironment2025

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[Journal Article] Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment2024

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[Journal Article] Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity2024

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[Journal Article] CD106 in tumor-specific exhausted CD8+ T cells mediates immunosuppression by inhibiting TCR signaling2024

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[Journal Article] Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling2024

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[Journal Article] Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens2023

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[Journal Article] Activated CTLA‐4‐independent immunosuppression of Treg cells disturbs CTLA‐4 blockade‐mediated antitumor immunity2023

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[Journal Article] Low frequency of intracranial progression in advanced NSCLC patients treated with cancer immunotherapies2023

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[Journal Article] Combination therapy with hydrogen peroxide and irradiation promotes an abscopal effect in mouse models2023

UEDA YUKI 上田優輝

Ueda Youki 上田優輝