Kitai Yuichi 鍛代悠一

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KITAI Yuichi 鍛代悠一

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Researcher Number	90756165
Other IDs
External Links
Affiliation (Current)	2022: 北海道大学, 薬学研究院, 助教
Affiliation (based on the past Project Information) *help	2018 – 2022: 北海道大学, 薬学研究院, 助教 2016: 北海道大学, 薬学研究院, 助教 2015: 北海道大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological pharmacy Except Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator がん免疫 / 自然免疫 / 抗がん剤 / 細胞死 / DAMPs / STING / 免疫学 / プログラム細胞死 / PROTAC Except Principal Investigator アレルギー … More / 免疫疾患 / 自己免疫 / サイトカイン / 免疫応答 / 炎症 / シグナル伝達 / 免疫 / 自己免疫疾患 / 疾患制御 / PET / がん免疫 / 乳酸 Less

エネルギー代謝に着目した核医学イメージングによるがん微小環境評価
- Principal Investigator
  
  小川美香子
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Hokkaido University
Development of novel PROTACs that activates antitumor immunityPrincipal Investigator
- Principal Investigator
  
  鍛代悠一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Hokkaido University
Study of signaling pathways for treatment of immune/allergic diseases
- Principal Investigator
  
  Matsuda Tadashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Hokkaido University
Analysis of novel programmed cell death pathway which induces antitumor immune activationPrincipal Investigator
- Principal Investigator
  
  Kitai Yuichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Hokkaido University
Analysis of antitumor immune activation via tumor cell-derived DNAPrincipal Investigator
- Principal Investigator
  
  KITAI Yuichi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University

All 2021 2020 2019 2017

All Journal Article Presentation Patent

[Journal Article] CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation2021
- Author(s)
  Kitai Yuichi、Ishiura Marie、Saitoh Kodai、Matsumoto Naoki、Owashi Kimiya、Yamada Shunsuke、Muromoto Ryuta、Kashiwakura Jun-ichi、Oritani Kenji、Matsuda Tadashi
- Journal Title
  
  International Immunology
  
  Volume: -
- DOI
  10.1093/intimm/dxab002
- NAID
  120007181805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03364
[Journal Article] Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice2021
- Author(s)
  Kashiwakura Jun-ichi、Yoshihara Mari、Saitoh Kodai、Kagohashi Kota、Sasaki Yuto、Kobayashi Fuki、Inagaki Iori、Kitai Yuichi、Muromoto Ryuta、Matsuda Tadashi
- Journal Title
  
  Allergology International
  
  Volume: - Issue: 3 Pages: 360-367
- DOI
  10.1016/j.alit.2020.11.005
- NAID
  130008064059
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03364
[Journal Article] Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic mice.2021
- Author(s)
  Saito H, Ichii M, Toda J, Kitai Y, Muromoto R, Kashiwakura JI, Saitoh K, Tanimura A, Yokota T, Shibayama H, Matsuda T, Oritani K, Kanakura Y, Hosen N.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 537 Pages: 118-124
- DOI
  10.1016/j.bbrc.2020.12.080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08815, KAKENHI-PROJECT-19K08861, KAKENHI-PROJECT-19H03364, KAKENHI-PROJECT-18K08355
[Journal Article] Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis2021
- Author(s)
  Sasaki Yuto、Saitoh Kodai、Kagohashi Kota、Kitai Yuichi、Muromoto Ryuta、Oritani Kenji、Kashiwakura Jun-ichi、Matsuda Tadashi
- Journal Title
  
  Biol. Pharm. Bull.
  
  Volume: 44 Issue: 12 Pages: 1898-1901
- DOI
  10.1248/bpb.b21-00595
- NAID
  130008123600
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08451, KAKENHI-PROJECT-21K15251
[Journal Article] Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation2021
- Author(s)
  Kashiwakura, Jun-ichi; Koizumi, Nao; Saitoh, Kodai; Kagohashi, Kota; Sasaki, Yuto; Kobayashi, Fuki; Kawahara, Shoya; Yamauchi, Yukie; Kitai, Yuichi; Muromoto, Ryuta; Oritani, Kenji; Matsuda, Tadashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 572 Pages: 80-85
- DOI
  10.1016/j.bbrc.2021.07.098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03364, KAKENHI-PROJECT-21K08451
[Journal Article] Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress.2021
- Author(s)
  Ichii Michiko、Oritani Kenji、Toda Jun、Saito Hideaki、Shi Henyun、Shibayama Hirohiko、Motooka Daisuke、Kitai Yuichi、Muromoto Ryuta、Kashiwakura Jun-ichi、Saitoh Kodai、Okuzaki Daisuke、Matsuda Tadashi、Kanakura Yuzuru
- Journal Title
  
  Haematologica.
  
  Volume: in press Pages: 225573-225573
- DOI
  10.3324/haematol.2019.225573
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08815, KAKENHI-PROJECT-18K14893, KAKENHI-PROJECT-19H03364, KAKENHI-PROJECT-19K08861, KAKENHI-PROJECT-19K17829
[Journal Article] Positive interactions between STAP-1 and BCR-ABL influence chronic myeloid leukemia cell proliferation and survival2021
- Author(s)
  Ishiura, Marie; Kitai, Yuichi; Kashiwakura, Jun-ichi; Muromoto, Ryuta; Toda, Jun; Ichii, Michiko; Oritani, Kenji; Matsuda, Tadashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 556 Pages: 185-191
- DOI
  10.1016/j.bbrc.2021.03.162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03364, KAKENHI-PROJECT-21K08451, KAKENHI-PROJECT-21K16243
[Journal Article] Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells2020
- Author(s)
  Kashiwakura Jun-ichi、Saitoh Kodai、Ihara Takeru、Sasaki Yuto、Kagohashi Kota、Enohara Shiyo、Morioka Yuka、Watarai Hiroshi、Muromoto Ryuta、Kitai Yuichi、Iwabuchi Kazuya、Oritani Kenji、Matsuda Tadashi
- Journal Title
  
  PLOS ONE
  
  Volume: 15
- DOI
  10.1371/journal.pone.0241440
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21522, KAKENHI-PROJECT-19H03364
[Journal Article] The mechanism of Tyk2 deficiency-induced immunosuppression in mice involves robust IL-10 production in macrophages2020
- Author(s)
  Hirashima Koki、Muromoto Ryuta、Minoguchi Hiroya、Matsumoto Tomohiro、Kitai Yuichi、Kashiwakura Jun-ichi、Shimoda Kazuya、Oritani Kenji、Matsuda Tadashi
- Journal Title
  
  Cytokine
  
  Volume: 130 Pages: 155077-155077
- DOI
  10.1016/j.cyto.2020.155077
- NAID
  120007097398
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14893, KAKENHI-PROJECT-19H03364, KAKENHI-PROJECT-17K08263
[Journal Article] Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML2020
- Author(s)
  Toda J, Ichii M, Oritani K, Shibayama H, Tanimura A, Saito H, Yokota T, Motooka D, Okuzaki D, Kitai Y, Muromoto R, Kashiwakura JI, Matsuda T, Hosen N, Kanakura Y.
- Journal Title
  
  Oncogene
  
  Volume: 39 Pages: 5601-5615
- DOI
  10.1038/s41388-020-01387-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08861, KAKENHI-PROJECT-20K08356, KAKENHI-PROJECT-19H03364, KAKENHI-PROJECT-20H03710, KAKENHI-PROJECT-18K08355, KAKENHI-PROJECT-19K17829
[Journal Article] Dimethyl fumarate dampens IL-17-ACT1-TBK1 axis-mediated phosphorylation of Regnase-1 and suppresses IL-17-induced IκB-ζ expression2020
- Author(s)
  Ohgakiuchi Yui、Saino Yuka、Muromoto Ryuta、Komori Yuki、Sato Ami、Hirashima Koki、Kitai Yuichi、Kashiwakura Jun-ichi、Oritani Kenji、Matsuda Tadashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 521 Pages: 957-963
- DOI
  10.1016/j.bbrc.2019.11.036
- NAID
  120007097378
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14893, KAKENHI-PROJECT-19H03364, KAKENHI-PROJECT-17K08263
[Journal Article] STAP-2 positively regulates FcgammaRI-mediated basophil activation and basophil-dependent allergic inflammatory reaction.2019
- Author(s)
  Kashiwakura Jun-ichi、Yamashita Shinsuke、Yoshihara Mari、Inui Kyosuke、Saitoh Kodai、Sekine Yuichi、Muromoto Ryuta、Kitai Yuichi、Oritani Kenji、Matsuda Tadashi
- Journal Title
  
  Int Immunol.
  
  Volume: 31 Pages: 349-356
- DOI
  10.1093/intimm/dxz013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14893, KAKENHI-PROJECT-18J10479, KAKENHI-PROJECT-16K09872, KAKENHI-PROJECT-19H03364
[Journal Article] IκB-ζ Expression Requires Both TYK2/STAT3 Activity and IL-17-Regulated mRNA Stabilization2019
- Author(s)
  Muromoto Ryuta、Tawa Keisuke、Ohgakiuchi Yui、Sato Ami、Saino Yuka、Hirashima Koki、Minoguchi Hiroya、Kitai Yuichi、Kashiwakura Jun-ichi、Shimoda Kazuya、Oritani Kenji、Matsuda Tadashi
- Journal Title
  
  ImmunoHorizons
  
  Volume: 3 Pages: 172-185
- DOI
  10.4049/immunohorizons.1900023
- NAID
  120007097377
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03364, KAKENHI-PROJECT-17K08263
[Journal Article] DNA-containing exosomes derived from cancer cells treated with Topotecan activate a STING-dependent pathway and reinforce antitumor immunity2017
- Author(s)
  Kitai Y, Kawasaki T, Sueyoshi T, Kobiyama K, Ishii KJ, Zou J, Akira S, Matsuda T, Kawai T.
- Journal Title
  
  J Immunology
  
  Volume: 198 Pages: 1649-1659
- DOI
  10.4049/jimmunol.1601694
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-15H01381, KAKENHI-PROJECT-15H05994, KAKENHI-PROJECT-26293107, KAKENHI-PROJECT-17K19559, KAKENHI-PROJECT-17H04066, KAKENHI-PROJECT-17K15598
[Patent] 抗腫瘍ペプチド及びその利用2021
- Inventor(s)
  松田　正,鍛代　悠一 ,織谷　健司
- Industrial Property Rights Holder
  北海道大学
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03364
[Presentation] Signal transducing adaptor protein (STAP)-2 accelerates graft-versus-host-disease.2020
- Author(s)
  Hideaki Saito，Michiko Ichii，Jun Toda，Yuichi Kitai，Ryuta Muromoto，Junichi Kashiwakura，Kodai Saitoh，Takafumi Yokota，Hirohiko Shibayama，Tadashi Matsuda，Kenji Oritani，Yuzuru Kanakura，Naoki Hosen.
- Organizer
  第82回日本血液学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-19H03364
[Presentation] 慢性骨髄性白血病幹細胞におけるアダプター蛋白STAP-1の役割2019
- Author(s)
  Jun Toda, Michiko Ichii, Kenji Oritani, Hideaki Saito, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Kodai Saitoh, Tadashi Matsuda, Yuzuru Kanakura
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19H03364
[Presentation] 自己免疫性肝炎病態制御におけるSTAP蛋白ファミリーの機能解析2019
- Author(s)
  齋藤浩大、柏倉淳一、室本竜太、鍛代悠一、吉村昭彦、織谷健司、松田正
- Organizer
  第56回　日本生化学会北海道支部　支部例会
- Data Source
  KAKENHI-PROJECT-19H03364
[Presentation] DNA-containing exosomes derived from cancer cells treated with Topotecan activate a STING-dependent pathway and reinforce antitumor immunity2017
- Author(s)
  鍛代悠一、雛健、末吉拓也、川崎拓実、小檜山康司、石井健、審良静男、松田正、河合太郎
- Organizer
  日本薬学会第137回年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-15H05994

1. Matsuda Tadashi (20212219)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
2. 室本竜太 (30455597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
3. 柏倉淳一 (90373290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
4. 小川美香子 (20344351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 平田健司 (30431365)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 久下裕司 (70321958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. WATARAI Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. KAWAI Taro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. ICHII Michiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. YOKOTA Takahumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. HOSEN Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 川崎拓実

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 柴山浩彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
14. 西東秀晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 金倉譲

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 戸田淳

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
17. 奥崎大介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 織谷健司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kitai Yuichi 鍛代 悠一

KITAI Yuichi 鍛代 悠一

Research Projects

Research Products

Co-Researchers

エネルギー代謝に着目した核医学イメージングによるがん微小環境評価

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel PROTACs that activates antitumor immunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of signaling pathways for treatment of immune/allergic diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of novel programmed cell death pathway which induces antitumor immune activationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of antitumor immune activation via tumor cell-derived DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic mice.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pivotal Role of Signal-Transducing Adaptor Protein-2 in Pathogenesis of Autoimmune Hepatitis2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Positive interactions between STAP-1 and BCR-ABL influence chronic myeloid leukemia cell proliferation and survival2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells2020

Author(s)

Journal Title

Kitai Yuichi 鍛代悠一

KITAI Yuichi 鍛代悠一