hara takato 原崇人

… Alternative Names

HARA Takato 原崇人

Less

Researcher Number	90805681
Other IDs
Affiliation (Current)	2025: 東邦大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2023: 東邦大学, 薬学部, 講師 2018 – 2020: 東邦大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 58020:Hygiene and public health-related: including laboratory approach Except Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator 血管内皮細胞 / カドミウム / タイトジャンクション / 毒性学 / ZO-1 / Claudin-5 / 密着結合 / 脱着傷害 / デルマタン硫酸 / CHSY1 / 動脈硬化 / プロテオグリカン / デルマタン硫酸糖鎖 … More Except Principal Investigator … More バイオオルガノメタリクス / プラスミノーゲンアクチベーターインヒビター1型 / 線溶 / 鉛 / PAI-1 / t-PA / ハイブリッド分子 / プラスミノーゲンアクチベーターインヒビター1型 / 組織型プラスミノーゲンアクチベーター / プラスミノーゲンアクチベータインヒビター1 / 線溶系 / 血管内皮細胞 / カドミウム Less

Effects of cadmium on tight junction of vascular endothelial cells: clarification of the mechanism of detachment injuryPrincipal Investigator
- Principal Investigator
  
  原崇人
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Toho University
Clarification of dermatan sulfate elongation mechanism that promotes onset and progress of atherosclerosis by cadmiumPrincipal Investigator
- Principal Investigator
  
  HARA Takato
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  Toho University
Intracellular signal pathways that are involved in the regulation of fibrinolysis by vascular endothelial cells
- Principal Investigator
  
  YAMAMOTO Chika
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Toho University

All 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Cadmium induces chondroitin sulfate synthase 1 via protein kinase Cα and elongates chondroitin/dermatan sulfate chains in cultured vascular endothelial cells2023
- Author(s)
  Hara Takato、Matsuura Shogo、Aikawa Keita、Shirai Misaki、Yoshida Mai、Kaji Toshiyuki、Yamamoto Chika
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 48 Issue: 8 Pages: 457-467
- DOI
  10.2131/jts.48.457
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17355
[Journal Article] Lead suppresses perlecan expression via EGFR-ERK1/2-COX-2-PGI2 pathway in cultured bovine vascular endothelial cells2023
- Author(s)
 Hara Takato、Kumagai Reina、Tanaka Tohru、Nakano Tsuyoshi、Fujie Tomoya、Fujiwara Yasuyuki、Yamamoto Chika、Kaji Toshiyuki
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 48 Issue: 12 Pages: 655-663
- DOI
 10.2131/jts.48.655
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-22K17355
[Journal Article] Cadmium induces plasminogen activator inhibitor-1 via Smad2/3 signaling pathway in human endothelial EA.hy926 cells2021
- Author(s)
  Hara Takato、Sakuma Miki、Fujie Tomoya、Kaji Toshiyuki、Yamamoto Chika
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 46 Issue: 5 Pages: 249-253
- DOI
  10.2131/jts.46.249
- NAID
  130008033315
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06638
[Journal Article] Syndecan-1 downregulates syndecan-4 expression by suppressing the ERK1/2 and p38 MAPK signaling pathways in cultured vascular endothelial cells2021
- Author(s)
  Hara, T., Sato, A., Yamamoto, C., Kaji, T.
- Journal Title
  
  BB Reports
  
  Volume: 26 Pages: 101001-101001
- DOI
  10.1016/j.bbrep.2021.101001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K19418
[Journal Article] Fibroblast Growth Factor-2 Upregulates Reactive Sulfur Species Production via ERK1/2 Signal-Mediated Cystathionine γ-Lyase Induction in Cultured Bovine Aortic Endothelial Cells2021
- Author(s)
 Takahashi, M., Kubota, T., Fujie, T., Shinkai, Y., Kumagai, Y., Nakano, T., Hara, T., Yamamoto, C.* and Kaji, T.*
- Journal Title
 
 BPB Reports
 
 Volume: 4 Issue: 6 Pages: 175-181
- DOI
 10.1248/bpbreports.4.6_175
- NAID
 130008115933
- ISSN
 2434-432X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K16361, KAKENHI-PROJECT-19K19418, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-20H04340
[Journal Article] Cell density-dependent fibroblast growth factor-2 signaling regulates syndecan-4 expression in cultured vascular endothelial cells2020
- Author(s)
  Takato Hara, Shiori Yabushita, Chika Yamamoto and Toshiyuki Kaji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 10 Pages: 3698-3698
- DOI
  10.3390/ijms21103698
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K19418
[Journal Article] Cell density-dependent modulation of perlecan synthesis by dichloro(2,9-dimethyl-1,10-phenanthroline)zinc(II) in vascular endothelial cells2020
- Author(s)
  Takato Hara, Sayaka Sakamaki, Atsuya Ikeda, Takehiro Nakamura, Chika Yamamoto, Toshiyuki Kaji
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 45 Issue: 2 Pages: 109-115
- DOI
  10.2131/jts.45.109
- NAID
  130007798450
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07089, KAKENHI-PROJECT-19K19418
[Presentation] 培養血管内皮細胞におけるtight junction関連分子の発現に重金属が及ぼす影響2023
- Author(s)
  原崇人，大畠ちなみ，浅津茉優花，藤江智也，山本千夏
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K17355
[Presentation] カドミウムによる血管内皮細胞脱着傷害に対するclaudin-5およびZO-1の寄与2023
- Author(s)
  中田千晶，片山晴香，浅津茉優花，原崇人，藤江智也，山本千夏
- Organizer
  フォーラム2023　衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-22K17355
[Presentation] カドミウムによる血管内皮細胞tight junctionの脆弱化2022
- Author(s)
  原崇人，大畠ちなみ，浅津茉優花，藤江智也，山本千夏
- Organizer
  メタルバイオサイエンス研究会2022
- Data Source
  KAKENHI-PROJECT-22K17355
[Presentation] ヒト血管内皮細胞株EA.hy926細胞におけるカドミウムによるPAI-1発現誘導メカニズムの探索2021
- Author(s)
  原崇人，佐久間美岐，藤江智也，鍜冶利幸，山本千夏
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06638
[Presentation] 血管内皮細胞においてt-PA発現を誘導するターピリジン亜鉛錯体2021
- Author(s)
  藤江智也，原崇人，伊藤愛，鍜冶利幸，山本千夏
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K06638
[Presentation] 血管内皮細胞のビグリカン発現にCREBが及ぼす影響2021
- Author(s)
  畑純菜, 石井美穂, 原崇人, 藤江智也, 鍜冶利幸, 山本千夏
- Organizer
  フォーラム2021 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-19K19418
[Presentation] CHSY1によるカドミウムの内皮細胞毒性の修飾2021
- Author(s)
  原崇人, 鬼澤秀太, 鍜冶利幸, 山本千夏
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K19418
[Presentation] CHSY1の発現誘導を介したカドミウムによる内皮細胞毒性の増強とビグリカン合成の変化2020
- Author(s)
  原崇人，松浦将吾，相川恵太，鬼澤秀太，吉田真衣，鍜冶利幸，山本千夏
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K19418
[Presentation] カドミウムによるヒト血管内皮細胞株EA.hy926細胞のPAI-1発現の誘導2020
- Author(s)
  原崇人，佐久間美岐，藤江智也，鍜冶利幸，山本千夏
- Organizer
  生命金属に関する合同年会（ConMetal 2020）
- Data Source
  KAKENHI-PROJECT-18K06638
[Presentation] Cadmium elongates the dermatan sulfate chains of biglycan in vascular endothelial cells2019
- Author(s)
  Hara, T., Matsuura, S., Aikawa, K., Yoshida, M., Yamamoto, C., Kaji, T.
- Organizer
  Proteoglycan2019: 11th International Conference on Proteoglycans
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K19418
[Presentation] カドミウムによる内皮細胞プロテオグリカン合成の攪乱-動脈硬化のシグナルトキシコロジー2019
- Author(s)
  原崇人, 山本千夏, 鍜冶利幸
- Organizer
  メタルバイオサイエンス研究会2019
- Invited
- Data Source
  KAKENHI-PROJECT-19K19418
[Presentation] Cadmium elongates the dermatan sulfate chains of biglycan in vascular endothelial cells2019
- Author(s)
  Hara, T., Matsuura, S., Aikawa, K., Yoshida, M., Yamamoto, C., Kaji, T.
- Organizer
  Proteoglycans Future Leaders Symposium 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K19418
[Presentation] カドミウムは血管内皮細胞が合成するビグリカンのデルマタン硫酸糖鎖を伸長する2019
- Author(s)
  原崇人, 山本千夏, 鍜冶利幸
- Organizer
  第46回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-19K19418

1. YAMAMOTO Chika (70230571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 藤江智也 (20780886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 鍛冶利幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

hara takato 原 崇人

HARA Takato 原 崇人

Research Projects

Research Products

Co-Researchers

Effects of cadmium on tight junction of vascular endothelial cells: clarification of the mechanism of detachment injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of dermatan sulfate elongation mechanism that promotes onset and progress of atherosclerosis by cadmiumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Intracellular signal pathways that are involved in the regulation of fibrinolysis by vascular endothelial cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Cadmium induces chondroitin sulfate synthase 1 via protein kinase Cα and elongates chondroitin/dermatan sulfate chains in cultured vascular endothelial cells2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Lead suppresses perlecan expression <i>via</i> EGFR-ERK1/2-COX-2-PGI<sub>2</sub> pathway in cultured bovine vascular endothelial cells2023

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Cadmium induces plasminogen activator inhibitor-1 via Smad2/3 signaling pathway in human endothelial EA.hy926 cells2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Syndecan-1 downregulates syndecan-4 expression by suppressing the ERK1/2 and p38 MAPK signaling pathways in cultured vascular endothelial cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fibroblast Growth Factor-2 Upregulates Reactive Sulfur Species Production <i>via</i> ERK1/2 Signal-Mediated Cystathionine γ-Lyase Induction in Cultured Bovine Aortic Endothelial Cells2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Cell density-dependent fibroblast growth factor-2 signaling regulates syndecan-4 expression in cultured vascular endothelial cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell density-dependent modulation of perlecan synthesis by dichloro(2,9-dimethyl-1,10-phenanthroline)zinc(II) in vascular endothelial cells2020

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Presentation] 培養血管内皮細胞におけるtight junction関連分子の発現に重金属が及ぼす影響2023

Author(s)

Organizer

Data Source

[Presentation] カドミウムによる血管内皮細胞脱着傷害に対するclaudin-5およびZO-1の寄与2023

Author(s)

Organizer

Data Source

[Presentation] カドミウムによる血管内皮細胞tight junctionの脆弱化2022

hara takato 原崇人

HARA Takato 原崇人