Semba Yuichiro 仙波雄一郎

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Yuichiro Semba 仙波雄一郎

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Researcher Number	90816787
Affiliation (Current)	2025: 九州大学, 医学研究院, 助教
Affiliation (based on the past Project Information) *help	2023 – 2025: 九州大学, 医学研究院, 助教 2022 – 2023: 九州大学, 大学病院, 助教 2019 – 2023: 京都大学, 医学研究科, 特別研究員(PD) 2018: 九州大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Basic Section 54020:Connective tissue disease and allergy-related / Broad Section I
Keywords	Principal Investigator CRISPRスクリーニング / 急性骨髄性白血病 / CRISPR-Cas9 screening / クロマチンリモデリング因子 / 白血病 Except Principal Investigator 急性骨髄性白血病 / 白血病 / 炎症性腸疾患 / 脊椎関節炎 / 巨細胞性動脈炎 … More / 加齢性クローナル造血 / 成人スチル病 / クローン性造血 / 老化 / inflammaging / ベーチェット病 / クローナル造血 / 代謝 / 白血病幹細胞 / TIM-3 / 機能ジェノミクス / CRISPR/Cas9 / 急性リンパ性白血病 / BCL2阻害剤 / CRSPR/Cas9 / BCL2 / ALL / AML / CRISPR / 合成致死 / p53 / TP53 / 急性白血病 Less

Exploring synthetic lethality as a therapeutic target for refractory cancer
- Principal Investigator
  
  前田高宏
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kyushu University
難治性TP53変異白血病における治療抵抗運命クローンのエピゲノム病態解明Principal Investigator
- Principal Investigator
  
  仙波雄一郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyushu University
自己免疫疾患における加齢性クローナル造血の関連についての検討
- Principal Investigator
  
  小野伸之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kyushu University
難治性TP53変異白血病の治療抵抗性獲得機序の解明と新規治療標的の探索Principal Investigator
- Principal Investigator
  
  仙波雄一郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyushu University
lucidation of molecular function of TIM-3 in human leukemic stem cells
- Principal Investigator
  
  Akashi Koichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Kyushu University
Development of novel therapeutic strategies for therapy-refractory leukemia
- Principal Investigator
  
  前田高宏
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  Kyushu University
CRISPR-Cas9 screen identifies essential chromatin-remodeling factors and novel therapeutic targets for acute myeloid leukemiaPrincipal Investigator
- Principal Investigator
  
  Yuichiro Semba
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyoto University
  Kyushu University

All 2023 2022 2020 2019

All Journal Article Presentation

[Journal Article] POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis2023
- Author(s)
  Nakashima Kentaro、Kunisaki Yuya、Hosokawa Kentaro、Gotoh Kazuhito、Yao Hisayuki、Yuta Ryosuke、Semba Yuichiro、Nogami Jumpei、Kikushige Yoshikane、Stumpf Patrick S.、MacArthur Ben D.、Kang Dongchon、Akashi Koichi、Ohga Shouichi、Arai Fumio
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1-14
- DOI
  10.1038/s42003-023-05374-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18301, KAKENHI-PROJECT-23K07861, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-23K27626
[Journal Article] Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance2023
- Author(s)
  Nakao Fumihiko、Setoguchi Kiyoko、Semba Yuichiro、Yamauchi Takuji、Nogami Jumpei、Sasaki Kensuke、Imanaga Hiroshi、Terasaki Tatsuya、Miyazaki Manaka、Hirabayashi Shigeki、Miyawaki Kohta、Kikushige Yoshikane、Masuda Takeshi、Akashi Koichi、Maeda Takahiro
- Journal Title
  
  Leukemia
  
  Volume: - Issue: 5 Pages: 1028-1038
- DOI
  10.1038/s41375-023-01879-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16323, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-23K07816, KAKENHI-PROJECT-20H05699, KAKENHI-PROJECT-21H04827
[Journal Article] Macrophages are primed to transdifferentiate into fibroblasts in malignant ascites and pleural effusions2022
- Author(s)
  Ito Mamoru、Nakano Michitaka、Ariyama Hiroshi、Yamaguchi Kyoko、Tanaka Risa、Semba Yuichiro、Sugio Takeshi、Miyawaki Kohta、Kikushige Yoshikane、Mizuno Shinichi、Isobe Taichi、Tanoue Kenro、Taguchi Ryosuke、Ueno Shohei、Kawano Takahito、Murata Masaharu、Baba Eishi、Akashi Koichi
- Journal Title
  
  Cancer Letters
  
  Volume: 532 Pages: 215597-215597
- DOI
  10.1016/j.canlet.2022.215597
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21617, KAKENHI-PROJECT-19H03687, KAKENHI-PROJECT-20J00897, KAKENHI-PROJECT-20K08311, KAKENHI-PROJECT-21K07152, KAKENHI-PROJECT-21K12685, KAKENHI-PROJECT-21K18325, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-23K25209, KAKENHI-PROJECT-19K16852, KAKENHI-PROJECT-20K17403
[Journal Article] A Germinal Center-Associated Microenvironmental Signature Reflects Malignant Phenotype and Outcome of DLBCL.2022
- Author(s)
  Miyawaki K, Kato K, Sugio T, Sasaki K, Miyoshi H, Semba Y, Kikushige Y, Mori Y, Kunisaki Y, Iwasaki H, Miyamoto T, Kuo FC, Aster JC, Ohshima K, Maeda T, Akashi K.
- Journal Title
  
  Blood Adv.
  
  Volume: 6 Issue: 7 Pages: 2388-2402
- DOI
  10.1182/bloodadvances.2021004618
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08818, KAKENHI-PROJECT-20K21617, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-19H03687, KAKENHI-PROJECT-20J00897, KAKENHI-PROJECT-22K19544, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-21H02951, KAKENHI-PROJECT-20K07381, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-20K17403
[Journal Article] TET2 Clonal Hematopoiesis Is Associated With Anthracycline-Induced Cardiotoxicity in Patients With Lymphoma2022
- Author(s)
  Hatakeyama Kiwamu、Hieda Michinari、Semba Yuichiro、Moriyama Shohei、Wang Yuqing、Maeda Takahiro、Kato Koji、Miyamoto Toshihiro、Akashi Koichi、Kikushige Yoshikane
- Journal Title
  
  JACC: CardioOncology
  
  Volume: 4 Issue: 1 Pages: 141-143
- DOI
  10.1016/j.jaccao.2022.01.098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21617, KAKENHI-PROJECT-19H03687, KAKENHI-PROJECT-22K19544, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-23K24364
[Journal Article] Human acute leukemia utilizes branched-chain amino acid catabolism to maintain stemness through regulating PRC2 function2022
- Author(s)
  Kikushige Yoshikane、Miyamoto Toshihiro、Kochi Yu、Semba Yuichiro、Ohishi Maki、Irifune Hidetoshi、Hatakeyama Kiwamu、Kunisaki Yuya、Sugio Takeshi、Sakoda Teppei、Miyawaki Kohta、Kato Koji、Soga Tomoyoshi、Akashi Koichi
- Journal Title
  
  Blood Advances
  
  Volume: - Issue: 14 Pages: 3592-3603
- DOI
  10.1182/bloodadvances.2022008242
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08479, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-23K24364, KAKENHI-ORGANIZER-23H04939, KAKENHI-PROJECT-21H02951, KAKENHI-PROJECT-20K17403
[Journal Article] Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL2022
- Author(s)
  Sasaki Kensuke、Yamauchi Takuji、Semba Yuichiro、Nogami Jumpei、Imanaga Hiroshi、Terasaki Tatsuya、Nakao Fumihiko、Akahane Koshi、Inukai Takeshi、Verhoeyen Els、Akashi Koichi、Maeda Takahiro
- Journal Title
  
  Blood
  
  Volume: 139 Issue: 5 Pages: 748-760
- DOI
  10.1182/blood.2021012976
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-21H04827
[Journal Article] Targeting leukemia-specific dependence on the de novo purine synthesis pathway.2022
- Author(s)
  Yamauchi T, Miyawaki K, Semba Y, Takahashi M, Izumi Y, Nogami J, Nakao F, Sugio T, Sasaki K, Pinello L, Bauer DE, Bamba T, Akashi K, Maeda T*.
- Journal Title
  
  Leukemia
  
  Volume: 36(2) Issue: 2 Pages: 383-393
- DOI
  10.1038/s41375-021-01369-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05167, KAKENHI-PLANNED-17H06304, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-20J00897, KAKENHI-PROJECT-20K17403, KAKENHI-PROJECT-20K15101
[Journal Article] Beneficial tyrosine kinase inhibitor therapy in a patient with relapsed BCR-ABL1-like acute lymphoblastic leukemia with CCDC88C-PDGFRB fusion2020
- Author(s)
  Oya Shuki、Morishige Satoshi、Ozawa Hidetoshi、Sasaki Kensuke、Semba Yuichiro、Yamasaki Yoshitaka、Nakamura Takayuki、Aoyama Kazutoshi、Seki Ritsuko、Mouri Fumihiko、Osaki Koichi、Miyamoto Toshihiro、Maeda Takahiro、Nagafuji Koji
- Journal Title
  
  International Journal of Hematology
  
  Volume: 113 Issue: 2 Pages: 285-289
- DOI
  10.1007/s12185-020-03006-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H05699
[Presentation] THE XPO7/NPAT AXIS AS A POTENTIAL THERAPEUTIC TARGET FOR TP53-MUTATED AML2023
- Author(s)
  Yuichiro Semba, Takuji Yamauchi, Fumihiko Nakao, Jumpei Nogami, Seishi Ogawa, Koichi Akashi and Takahiro Maeda
- Organizer
  the 2023 FASEB hematological malignancies meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16303
[Presentation] The XPO7/Npat Axis Inactivation Is a Therapeutic Vulnerability for TP53-Mutated AML2023
- Author(s)
  Yuichiro Semba
- Organizer
  American Society of Hematology annual meeting, San Diego, LA, USA. 2023.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H05699
[Presentation] The XPO7/Npat Axis Inactivation Is a Therapeutic Vulnerability for TP53-Mutated AML2023
- Author(s)
  Yuichiro Semba, Takuji Yamauchi, Fumihiko Nakao, Jumpei Nogami, Seishi Ogawa, Koichi Akashi and Takahiro Maeda
- Organizer
  the 65th ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16303
[Presentation] The XPO7/NPAT axis is a potential therapeutic target for TP53-mutated AML2022
- Author(s)
  仙波雄一郎、山内拓司、中尾文彦、野上順平、Qiuming Yao、Matthew Canver、増田豪、Luca Pinello、Daniel Bauer、小川誠司、赤司浩一、前田高宏
- Organizer
  第84回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16303
[Presentation] The XPO7/Npat Axis Is a Potential Therapeutic Target for TP53-Mutated AML2022
- Author(s)
  Yuichiro Semba, Takuji Yamauchi, Fumihiko Nakao, Jumpei Nogami, Seishi Ogawa, Koichi Akashi, Takahiro Maeda
- Organizer
  64TH ASH ANNUAL MEETING AND EXPOSITION
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16303
[Presentation] 網羅的全ゲノム編集技術を駆使したTP53変異白血病の新規治療標的探索2020
- Author(s)
  Semba Y, Yamauchi T, Nakao F, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K and Maeda T.
- Organizer
  第118回日本内科学会講演会
- Data Source
  KAKENHI-PROJECT-18K16089
[Presentation] CRISPR-Cas9 screen identifies XPO7 as a novel therapeutic target for TP53-mutated AML.2019
- Author(s)
  Semba Y, Yamauchi T, Nakao F, Nogami J, Yao Q, Canver MC, Pinello L, Bauer DE, Akashi K, Maeda T.
- Organizer
  The FASEB Hematologic Malignancies Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16089
[Presentation] CRISPR-Cas9 Screen Identifies XPO7 as a Novel Therapeutic Target for TP53-mutated AML.2019
- Author(s)
  Semba Y, Yamauchi T, Nakao F, Yao Q, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K and Maeda T.
- Organizer
  The seventh annual meeting of the Society of Hematologic Oncology (SOHO)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16089
[Presentation] CRISPR-Cas9 Screen Identifies XPO7 As a Potential Therapeutic Target for TP53-Mutated AML.2019
- Author(s)
  Semba Y, Yamauchi T, Nakao F, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K and Maeda T.
- Organizer
  The 61st American Society of Hematology (ASH) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16089
[Presentation] Genome-wide CRISPR-Cas9 screen identifies novel therapeutic targets for TP53-mutated AML.2019
- Author(s)
  Semba Y, Yamauchi T, Nakao F, Yao Q, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K and Maeda T.
- Organizer
  The 81st Annual Meeting of the Japanese Society of Hematology (JSH)
- Data Source
  KAKENHI-PROJECT-18K16089

1. 前田高宏 (00791972)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
2. Akashi Koichi (80380385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 山内拓司 (20796213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 野上順平 (60801751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 増田豪 (70383940)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 加藤光次 (20571764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 菊繁吉謙 (40619706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 森康雄 (90573345)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 宮本敏浩 (70343324)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 小野伸之 (00336025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 江里口芳裕 (70552016)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 平林茂樹 (30910947)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 米満吉和 (40315065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ARAI Fumio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 犬飼岳史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 赤羽弘資

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 和泉自泰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Semba Yuichiro 仙波 雄一郎

Yuichiro Semba 仙波 雄一郎

Research Projects

Research Products

Co-Researchers

Exploring synthetic lethality as a therapeutic target for refractory cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

難治性TP53変異白血病における治療抵抗運命クローンのエピゲノム病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自己免疫疾患における加齢性クローナル造血の関連についての検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

難治性TP53変異白血病の治療抵抗性獲得機序の解明と新規治療標的の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

lucidation of molecular function of TIM-3 in human leukemic stem cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapeutic strategies for therapy-refractory leukemia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

CRISPR-Cas9 screen identifies essential chromatin-remodeling factors and novel therapeutic targets for acute myeloid leukemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Macrophages are primed to transdifferentiate into fibroblasts in malignant ascites and pleural effusions2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Germinal Center-Associated Microenvironmental Signature Reflects Malignant Phenotype and Outcome of DLBCL.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TET2 Clonal Hematopoiesis Is Associated With Anthracycline-Induced Cardiotoxicity in Patients With Lymphoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human acute leukemia utilizes branched-chain amino acid catabolism to maintain stemness through regulating PRC2 function2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL2022

Author(s)

Journal Title

Semba Yuichiro 仙波雄一郎

Yuichiro Semba 仙波雄一郎