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Semba Yuichiro  仙波 雄一郎

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Yuichiro Semba  仙波 雄一郎

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Researcher Number 90816787
Affiliation (Current) 2025: 九州大学, 医学研究院, 助教
Affiliation (based on the past Project Information) *help 2023 – 2025: 九州大学, 医学研究院, 助教
2022 – 2023: 九州大学, 大学病院, 助教
2019 – 2023: 京都大学, 医学研究科, 特別研究員(PD)
2018: 九州大学, 大学病院, 医員
Review Section/Research Field
Principal Investigator
Basic Section 54010:Hematology and medical oncology-related
Except Principal Investigator
Basic Section 54020:Connective tissue disease and allergy-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Broad Section I
Keywords
Principal Investigator
CRISPRスクリーニング / 急性骨髄性白血病 / CRISPR-Cas9 screening / クロマチンリモデリング因子 / 白血病
Except Principal Investigator
急性骨髄性白血病 / 炎症性腸疾患 / 脊椎関節炎 / 巨細胞性動脈炎 / 加齢性クローナル造血 … More / 成人スチル病 / クローン性造血 / 老化 / inflammaging / ベーチェット病 / クローナル造血 / 代謝 / 白血病幹細胞 / TIM-3 / 機能ジェノミクス / CRISPR/Cas9 / 急性リンパ性白血病 / BCL2阻害剤 / CRSPR/Cas9 / BCL2 / ALL / AML / CRISPR / 合成致死 / p53 / TP53 / 急性白血病 Less
  • Research Projects

    (6 results)
  • Research Products

    (19 results)
  • Co-Researchers

    (16 People)
  •  難治性TP53変異白血病における治療抵抗運命クローンのエピゲノム病態解明Principal Investigator

    • Principal Investigator
      仙波 雄一郎
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kyushu University
  •  自己免疫疾患における加齢性クローナル造血の関連についての検討

    • Principal Investigator
      小野 伸之
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Kyushu University
  •  難治性TP53変異白血病の治療抵抗性獲得機序の解明と新規治療標的の探索Principal Investigator

    • Principal Investigator
      仙波 雄一郎
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kyushu University
  •  lucidation of molecular function of TIM-3 in human leukemic stem cells

    • Principal Investigator
      Akashi Koichi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      Kyushu University
  •  Development of novel therapeutic strategies for therapy-refractory leukemia

    • Principal Investigator
      前田 高宏
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section I
    • Research Institution
      Kyushu University
  •  CRISPR-Cas9 screen identifies essential chromatin-remodeling factors and novel therapeutic targets for acute myeloid leukemiaPrincipal Investigator

    • Principal Investigator
      Yuichiro Semba
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kyoto University
      Kyushu University

All 2023 2022 2020 2019

All Journal Article Presentation

  • [Journal Article] POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis2023

    • Author(s)
      Nakashima Kentaro、Kunisaki Yuya、Hosokawa Kentaro、Gotoh Kazuhito、Yao Hisayuki、Yuta Ryosuke、Semba Yuichiro、Nogami Jumpei、Kikushige Yoshikane、Stumpf Patrick S.、MacArthur Ben D.、Kang Dongchon、Akashi Koichi、Ohga Shouichi、Arai Fumio
    • Journal Title

      Communications Biology

      Volume: 6 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s42003-023-05374-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K18301, KAKENHI-PROJECT-23K07861, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-23K27626
  • [Journal Article] Targeting a mitochondrial E3 ubiquitin ligase complex to overcome AML cell-intrinsic Venetoclax resistance2023

    • Author(s)
      Nakao Fumihiko、Setoguchi Kiyoko、Semba Yuichiro、Yamauchi Takuji、Nogami Jumpei、Sasaki Kensuke、Imanaga Hiroshi、Terasaki Tatsuya、Miyazaki Manaka、Hirabayashi Shigeki、Miyawaki Kohta、Kikushige Yoshikane、Masuda Takeshi、Akashi Koichi、Maeda Takahiro
    • Journal Title

      Leukemia

      Volume: - Issue: 5 Pages: 1028-1038

    • DOI

      10.1038/s41375-023-01879-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K16323, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-23K07816, KAKENHI-PROJECT-20H05699, KAKENHI-PROJECT-21H04827
  • [Journal Article] Macrophages are primed to transdifferentiate into fibroblasts in malignant ascites and pleural effusions2022

    • Author(s)
      Ito Mamoru、Nakano Michitaka、Ariyama Hiroshi、Yamaguchi Kyoko、Tanaka Risa、Semba Yuichiro、Sugio Takeshi、Miyawaki Kohta、Kikushige Yoshikane、Mizuno Shinichi、Isobe Taichi、Tanoue Kenro、Taguchi Ryosuke、Ueno Shohei、Kawano Takahito、Murata Masaharu、Baba Eishi、Akashi Koichi
    • Journal Title

      Cancer Letters

      Volume: 532 Pages: 215597-215597

    • DOI

      10.1016/j.canlet.2022.215597

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21617, KAKENHI-PROJECT-19H03687, KAKENHI-PROJECT-20J00897, KAKENHI-PROJECT-20K08311, KAKENHI-PROJECT-21K07152, KAKENHI-PROJECT-21K12685, KAKENHI-PROJECT-21K18325, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-23K25209, KAKENHI-PROJECT-19K16852, KAKENHI-PROJECT-20K17403
  • [Journal Article] A Germinal Center-Associated Microenvironmental Signature Reflects Malignant Phenotype and Outcome of DLBCL.2022

    • Author(s)
      Miyawaki K, Kato K, Sugio T, Sasaki K, Miyoshi H, Semba Y, Kikushige Y, Mori Y, Kunisaki Y, Iwasaki H, Miyamoto T, Kuo FC, Aster JC, Ohshima K, Maeda T, Akashi K.
    • Journal Title

      Blood Adv.

      Volume: 6 Issue: 7 Pages: 2388-2402

    • DOI

      10.1182/bloodadvances.2021004618

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08818, KAKENHI-PROJECT-20K21617, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-19H03687, KAKENHI-PROJECT-20J00897, KAKENHI-PROJECT-22K19544, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-21H02951, KAKENHI-PROJECT-20K07381, KAKENHI-PROJECT-23K24364, KAKENHI-PROJECT-20K17403
  • [Journal Article] TET2 Clonal Hematopoiesis Is Associated With Anthracycline-Induced Cardiotoxicity in Patients With Lymphoma2022

    • Author(s)
      Hatakeyama Kiwamu、Hieda Michinari、Semba Yuichiro、Moriyama Shohei、Wang Yuqing、Maeda Takahiro、Kato Koji、Miyamoto Toshihiro、Akashi Koichi、Kikushige Yoshikane
    • Journal Title

      JACC: CardioOncology

      Volume: 4 Issue: 1 Pages: 141-143

    • DOI

      10.1016/j.jaccao.2022.01.098

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21617, KAKENHI-PROJECT-19H03687, KAKENHI-PROJECT-22K19544, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-23K24364
  • [Journal Article] Human acute leukemia utilizes branched-chain amino acid catabolism to maintain stemness through regulating PRC2 function2022

    • Author(s)
      Kikushige Yoshikane、Miyamoto Toshihiro、Kochi Yu、Semba Yuichiro、Ohishi Maki、Irifune Hidetoshi、Hatakeyama Kiwamu、Kunisaki Yuya、Sugio Takeshi、Sakoda Teppei、Miyawaki Kohta、Kato Koji、Soga Tomoyoshi、Akashi Koichi
    • Journal Title

      Blood Advances

      Volume: - Issue: 14 Pages: 3592-3603

    • DOI

      10.1182/bloodadvances.2022008242

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K08479, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-21H02950, KAKENHI-PROJECT-23K24364, KAKENHI-ORGANIZER-23H04939, KAKENHI-PROJECT-21H02951, KAKENHI-PROJECT-20K17403
  • [Journal Article] Genome-wide CRISPR-Cas9 screen identifies rationally designed combination therapies for CRLF2-rearranged Ph-like ALL2022

    • Author(s)
      Sasaki Kensuke、Yamauchi Takuji、Semba Yuichiro、Nogami Jumpei、Imanaga Hiroshi、Terasaki Tatsuya、Nakao Fumihiko、Akahane Koshi、Inukai Takeshi、Verhoeyen Els、Akashi Koichi、Maeda Takahiro
    • Journal Title

      Blood

      Volume: 139 Issue: 5 Pages: 748-760

    • DOI

      10.1182/blood.2021012976

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03615, KAKENHI-PROJECT-21H04827
  • [Journal Article] Targeting leukemia-specific dependence on the de novo purine synthesis pathway.2022

    • Author(s)
      Yamauchi T, Miyawaki K, Semba Y, Takahashi M, Izumi Y, Nogami J, Nakao F, Sugio T, Sasaki K, Pinello L, Bauer DE, Bamba T, Akashi K, Maeda T*.
    • Journal Title

      Leukemia

      Volume: 36(2) Issue: 2 Pages: 383-393

    • DOI

      10.1038/s41375-021-01369-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K05167, KAKENHI-PLANNED-17H06304, KAKENHI-PROJECT-21H04827, KAKENHI-PROJECT-20J00897, KAKENHI-PROJECT-20K17403, KAKENHI-PROJECT-20K15101
  • [Journal Article] Beneficial tyrosine kinase inhibitor therapy in a patient with relapsed BCR-ABL1-like acute lymphoblastic leukemia with CCDC88C-PDGFRB fusion2020

    • Author(s)
      Oya Shuki、Morishige Satoshi、Ozawa Hidetoshi、Sasaki Kensuke、Semba Yuichiro、Yamasaki Yoshitaka、Nakamura Takayuki、Aoyama Kazutoshi、Seki Ritsuko、Mouri Fumihiko、Osaki Koichi、Miyamoto Toshihiro、Maeda Takahiro、Nagafuji Koji
    • Journal Title

      International Journal of Hematology

      Volume: 113 Issue: 2 Pages: 285-289

    • DOI

      10.1007/s12185-020-03006-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H05699
  • [Presentation] THE XPO7/NPAT AXIS AS A POTENTIAL THERAPEUTIC TARGET FOR TP53-MUTATED AML2023

    • Author(s)
      Yuichiro Semba, Takuji Yamauchi, Fumihiko Nakao, Jumpei Nogami, Seishi Ogawa, Koichi Akashi and Takahiro Maeda
    • Organizer
      the 2023 FASEB hematological malignancies meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K16303
  • [Presentation] The XPO7/Npat Axis Inactivation Is a Therapeutic Vulnerability for TP53-Mutated AML2023

    • Author(s)
      Yuichiro Semba
    • Organizer
      American Society of Hematology annual meeting, San Diego, LA, USA. 2023.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H05699
  • [Presentation] The XPO7/Npat Axis Inactivation Is a Therapeutic Vulnerability for TP53-Mutated AML2023

    • Author(s)
      Yuichiro Semba, Takuji Yamauchi, Fumihiko Nakao, Jumpei Nogami, Seishi Ogawa, Koichi Akashi and Takahiro Maeda
    • Organizer
      the 65th ASH Annual Meeting and Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K16303
  • [Presentation] The XPO7/NPAT axis is a potential therapeutic target for TP53-mutated AML2022

    • Author(s)
      仙波雄一郎、山内 拓司、中尾 文彦、野上 順平、Qiuming Yao、Matthew Canver、増田 豪、Luca Pinello、Daniel Bauer、小川 誠司、赤司 浩一、前田 高宏
    • Organizer
      第84回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-22K16303
  • [Presentation] The XPO7/Npat Axis Is a Potential Therapeutic Target for TP53-Mutated AML2022

    • Author(s)
      Yuichiro Semba, Takuji Yamauchi, Fumihiko Nakao, Jumpei Nogami, Seishi Ogawa, Koichi Akashi, Takahiro Maeda
    • Organizer
      64TH ASH ANNUAL MEETING AND EXPOSITION
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K16303
  • [Presentation] 網羅的全ゲノム編集技術を駆使したTP53変異白血病の新規治療標的探索2020

    • Author(s)
      Semba Y, Yamauchi T, Nakao F, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K and Maeda T.
    • Organizer
      第118回日本内科学会講演会
    • Data Source
      KAKENHI-PROJECT-18K16089
  • [Presentation] CRISPR-Cas9 screen identifies XPO7 as a novel therapeutic target for TP53-mutated AML.2019

    • Author(s)
      Semba Y, Yamauchi T, Nakao F, Nogami J, Yao Q, Canver MC, Pinello L, Bauer DE, Akashi K, Maeda T.
    • Organizer
      The FASEB Hematologic Malignancies Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16089
  • [Presentation] CRISPR-Cas9 Screen Identifies XPO7 as a Novel Therapeutic Target for TP53-mutated AML.2019

    • Author(s)
      Semba Y, Yamauchi T, Nakao F, Yao Q, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K and Maeda T.
    • Organizer
      The seventh annual meeting of the Society of Hematologic Oncology (SOHO)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16089
  • [Presentation] CRISPR-Cas9 Screen Identifies XPO7 As a Potential Therapeutic Target for TP53-Mutated AML.2019

    • Author(s)
      Semba Y, Yamauchi T, Nakao F, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K and Maeda T.
    • Organizer
      The 61st American Society of Hematology (ASH) Annual Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K16089
  • [Presentation] Genome-wide CRISPR-Cas9 screen identifies novel therapeutic targets for TP53-mutated AML.2019

    • Author(s)
      Semba Y, Yamauchi T, Nakao F, Yao Q, Nogami J, Canver MC, Pinello L, Bauer DE, Akashi K and Maeda T.
    • Organizer
      The 81st Annual Meeting of the Japanese Society of Hematology (JSH)
    • Data Source
      KAKENHI-PROJECT-18K16089
  • 1.  前田 高宏 (00791972)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 2.  Akashi Koichi (80380385)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  山内 拓司 (20796213)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  野上 順平 (60801751)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  増田 豪 (70383940)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  加藤 光次 (20571764)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  菊繁 吉謙 (40619706)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 8.  森 康雄 (90573345)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  宮本 敏浩 (70343324)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  小野 伸之 (00336025)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  江里口 芳裕 (70552016)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  ARAI Fumio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  犬飼 岳史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  赤羽 弘資
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  平林 茂樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  和泉 自泰
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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