Sonoda Keiko 園田桂子

Researcher Number	90824417
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, オープンイノベーションセンター, 上級研究員
Affiliation (based on the past Project Information) *help	2025: 国立研究開発法人国立循環器病研究センター, オープンイノベーションセンター, 上級研究員 2023: 国立研究開発法人国立循環器病研究センター, オープンイノベーションセンター, 上級研究員 2021 – 2023: 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 2022: 国立研究開発法人国立循環器病研究センター, メディカルゲノムセンター, 上級研究員 2019 – 2020: 国立研究開発法人国立循環器病研究センター, 研究所, 研究員(任期付)
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related Except Principal Investigator Basic Section 53020:Cardiology-related / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator ロングリードシークエンス / DNA構造多型 / 遺伝性心疾患 / 不整脈原性右室心筋症 / FFPE検体 / ＲＮＡシークエンス / トランスクリプトーム解析 / RNAシークエンス / Brugada症候群 / FFPE / リード抜去 / 遺伝性不整脈 … More Except Principal Investigator … More 遺伝性不整脈 / カテコラミン誘発性多型性心室頻拍 / リアノジン受容体遺伝子 / カテコラミン誘発多型性心室頻拍 / DNA構造多型 / DNA構造異常 / long read sequencer / ゲノム構造多型 / ゲノムDNA構造異常 Less

ロングリード技術を用いた心筋組織解析による不整脈原性右室心筋症の病態解明Principal Investigator
- Principal Investigator
  
  園田桂子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
遺伝的背景が不明なカテコラミン誘発多型性心室頻拍患者における遺伝子構造多型の検索
- Principal Investigator
  
  福山恵
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Shiga University of Medical Science
DNA構造多型同定による、不整脈原性右室心筋症の新たな遺伝的背景の解明Principal Investigator
- Principal Investigator
  
  園田桂子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
The elucidation of complicated genetic backgrounds and pathogenicity in patients with inherited primary arrhythmia syndromes caused by unknown etiology
- Principal Investigator
  
  大野聖子
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Cardiovascular Center Research Institute
Transcriptome analysis aimed to elucidate pathophysiological mechanism of inherited arrhythmiasPrincipal Investigator
- Principal Investigator
  
  Sonoda Keiko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Book

[Book] 臨床雑誌内科2023
- Author(s)
  園田桂子、大野聖子
- Total Pages
  5
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-22K16157
[Journal Article] Impact of cascade screening for catecholaminergic polymorphic ventricular tachycardia type 12022
- Author(s)
  Shimamoto K, Ohno S, Kato K, Takayama K, Sonoda K, Fukuyama M, Makiyama T, Okamura S, Asakura K, Imanishi N, Kato Y, Sakaguchi H, Kamakura T, Wada M, Yamagata K, Ishibashi K, Inoue Y, Miyamoto K, Nagase S, Kusano K, Horie M, Aiba T.
- Journal Title
  
  Heart
  
  Volume: - Issue: 11 Pages: 2021-320220
- DOI
  10.1136/heartjnl-2021-320220
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-19K08555, KAKENHI-PROJECT-21H02888, KAKENHI-PROJECT-21K07765, KAKENHI-PROJECT-19K08505, KAKENHI-PROJECT-19K17581
[Journal Article] Association Between Deleterious SCN5A Variants and Ventricular Septal Defect in Young Patients With Brugada Syndrome2022
- Author(s)
  Suzuki Keisuke、Sonoda Keiko、Aoki Hisaaki、Nakamura Yuko、Watanabe Seiichi、Yoshida Yoko、Hoshino Kenji、Ozawa Junichi、Imamura Tomohiko、Aiba Takeshi、Kato Koichi、Makiyama Takeru、Kusano Kengo、Horie Minoru、Ohno Seiko
- Journal Title
  
  JACC: Clinical Electrophysiology
  
  Volume: 8 Issue: 3 Pages: 297-305
- DOI
  10.1016/j.jacep.2022.01.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-21H02888, KAKENHI-PROJECT-19K08505, KAKENHI-PROJECT-19K17581
[Journal Article] Long-Read Sequence Confirmed a Large Deletion Including <i>MYH6</i> and <i>MYH7</i> in an Infant of Atrial Septal Defect and Atrial Arrhythmias2021
- Author(s)
  Sonoda Keiko、Ishihara Haruko、Sakazaki Hisanori、Suzuki Tsugutoshi、Horie Minoru、Ohno Seiko
- Journal Title
  
  Circulation: Genomic and Precision Medicine
  
  Volume: 14 Issue: 4
- DOI
  10.1161/circgen.120.003223
- NAID
  120007146546
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02888
[Journal Article] LMNA Missense Mutation Causes Nonsense-Mediated mRNA Decay and Severe Dilated Cardiomyopathy2020
- Author(s)
  Kato Koichi、Ohno Seiko、Sonoda Keiko、Fukuyama Megumi、Makiyama Takeru、Ozawa Tomoya、Horie Minoru
- Journal Title
  
  Circulation: Genomic and Precision Medicine
  
  Volume: 13 Issue: 5 Pages: 435-443
- DOI
  10.1161/circgen.119.002853
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-19K08555, KAKENHI-PROJECT-19K17581, KAKENHI-PROJECT-18K07875
[Journal Article] SCN5A mutation identified in a patient with short-coupled variant of torsades de pointes2020
- Author(s)
  Sonoda Keiko、Ohno Seiko、Shimizu Yukiko、Kaitani Kazuaki、Makiyama Takeru、Nakagawa Yoshihisa、Horie Minoru
- Journal Title
  
  Pacing and Clinical Electrophysiology
  
  Volume: - Issue: 5 Pages: 456-461
- DOI
  10.1111/pace.13924
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17581, KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-18K07875
[Presentation] Usefulness of Amplicon-based Long-read Sequencing for Detecting Zygosity of DSG2 Variants Related with Japanese ARVC.2024
- Author(s)
  Keiko Sonoda, Satoshi Nagase, Takeshi Aiba, Megumi Fukuyama, Koichi Kato, Noriko Kikuchi, Tsuyoshi Shiga, Kengo Kusano, Minoru Horie and Seiko Ohno.
- Organizer
  第88回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-22K16157
[Presentation] The pathogenic variants in PKP2 are associated with high risk of lethal ventricular arrhythmia in Japanese ARVC patients2023
- Author(s)
  Keiko Sonoda, Satoshi Nagase, Takeshi Aiba, Koichi Kato, Megumi Fukuyama, Noriko Kikuchi, Tsuyoshi Shiga, Kengo Kusano, Minoru Horie and Seiko Ohno
- Organizer
  第87回日本循環器学会学術総会
- Data Source
  KAKENHI-PROJECT-22K16157
[Presentation] Homozygous or compound heterozygous variants in DSG2 are mainly causative of Japanese arrhythmogenic right ventricular cardiomyopathy.2023
- Author(s)
  K. Sonoda , S. Nagase , T. Aiba , K. Kato , M. Fukuyama , N. Kikuchi , T. Shiga , M. Horie , S. Ohno
- Organizer
  ESC Congress 2023
- Data Source
  KAKENHI-PROJECT-22K08179
[Presentation] Homozygous or compound heterozygous variants in DSG2 are mainly causative of Japanese arrhythmogenic right ventricular cardiomyopathy.2023
- Author(s)
  K. Sonoda, S. Nagase, T. Aiba, K. Kato, M. Fukuyama, N. Kikuchi, T. Shiga, M. Horie, S. Ohno
- Organizer
  ESC Congress 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16157
[Presentation] 不整脈原性右室心筋症の遺伝的背景が関与する臨床像と予後2022
- Author(s)
  園田桂子, 永瀬聡, 相庭武司, 加藤浩一, 志賀剛, 草野研吾, 堀江稔, 大野聖子
- Organizer
  第8回日本心筋症研究会
- Data Source
  KAKENHI-PROJECT-22K16157
[Presentation] デスモゾーム関連遺伝子変異キャリアの小児期の特徴2022
- Author(s)
  大野　聖子, 園田桂子, 加藤浩一, 堀江稔
- Organizer
  第58回日本小児循環器学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21H02888
[Presentation] Different prognosis of ARVC patients between DSG2 and PKP2 variant carriers2022
- Author(s)
  Keiko Sonoda, Satoshi Nagase, Takeshi Aiba, Koichi Kato, Tsuyoshi Shiga, Kengo Kusano, Minoru Horie, Seiko Ohno
- Organizer
  ESC Congress 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16157
[Presentation] Different prognosis of ARVC patients between DSG2 and PKP2 variant carriers2022
- Author(s)
  Sonoda K, Nagase S, Aiba T, Kato K, Shiga T, Kusano K, Horie M, Ohno S.
- Organizer
  ESC Congress 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02888
[Presentation] 日本人カテコラミン誘発多形性心室頻拍患者における遺伝子変異頻度とその特徴2021
- Author(s)
  大野聖子、園田桂子、福山恵、加藤浩一、堀江稔.
- Organizer
  日本人類遺伝学会第66回大会
- Data Source
  KAKENHI-PROJECT-21H02888
[Presentation] 小児不整脈原性右室心筋症患者をいかに早期に診断するか2021
- Author(s)
  大野聖子、園田桂子
- Organizer
  第25回小児心電学会
- Data Source
  KAKENHI-PROJECT-21H02888
[Presentation] Early onset of heart failure in Japanese ARVC patients with pathogenic desmosomal gene variants2021
- Author(s)
  Sonoda K, Nagase S, Aiba T, Fukuyama M, Kato K, Kusano K, Horie M, Ohno S
- Organizer
  European Society of Cardiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02888
[Presentation] Copy Number Variation of SCN5A in Sick Sinus Syndrome2020
- Author(s)
  Keiko Sonoda, Hisaaki Aoki, Koichiro Takayama, Wang Qi, Dimitar P Zankov, Yoshihide Nakamura, Minoru Horie, Seiko Ohno
- Organizer
  第84回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17581
[Presentation] Long-read sequence confirmed a large deletion of MYH6 and MYH7 in a family with atrial septal defect2020
- Author(s)
  Keiko Sonoda, Seiko Ohno, Minoru Horie
- Organizer
  ESC Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17581
[Presentation] De novo RYR2 mutations are associated with severe phenotype of CPVT more strongly than inherited ones2019
- Author(s)
  Keiko Sonoda, Tetsuhisa Hattori, Minoru Horie, Seiko Ohno
- Organizer
  The American Society of Human Genetics 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17581

1. 大野聖子 (20610025)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. 福山恵 (60625771)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. ZANKOV DimitarP (20631295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 牧山武 (30528302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 相庭武司 (40574348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 加藤浩一 (70736983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 高山幸一郎 (20816988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Wang Qi (70756767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 堀江稔 (90183938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Sonoda Keiko 園田 桂子

Research Projects

Research Products

Co-Researchers

ロングリード技術を用いた心筋組織解析による不整脈原性右室心筋症の病態解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

遺伝的背景が不明なカテコラミン誘発多型性心室頻拍患者における遺伝子構造多型の検索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNA構造多型同定による、不整脈原性右室心筋症の新たな遺伝的背景の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The elucidation of complicated genetic backgrounds and pathogenicity in patients with inherited primary arrhythmia syndromes caused by unknown etiology

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Transcriptome analysis aimed to elucidate pathophysiological mechanism of inherited arrhythmiasPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 臨床雑誌内科2023

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Impact of cascade screening for catecholaminergic polymorphic ventricular tachycardia type 12022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association Between Deleterious SCN5A Variants and Ventricular Septal Defect in Young Patients With Brugada Syndrome2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Long-Read Sequence Confirmed a Large Deletion Including <i>MYH6</i> and <i>MYH7</i> in an Infant of Atrial Septal Defect and Atrial Arrhythmias2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] LMNA Missense Mutation Causes Nonsense-Mediated mRNA Decay and Severe Dilated Cardiomyopathy2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SCN5A mutation identified in a patient with short-coupled variant of torsades de pointes2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Usefulness of Amplicon-based Long-read Sequencing for Detecting Zygosity of DSG2 Variants Related with Japanese ARVC.2024

Author(s)

Organizer

Data Source

[Presentation] The pathogenic variants in PKP2 are associated with high risk of lethal ventricular arrhythmia in Japanese ARVC patients2023

Author(s)

Organizer

Data Source

[Presentation] Homozygous or compound heterozygous variants in DSG2 are mainly causative of Japanese arrhythmogenic right ventricular cardiomyopathy.2023

Author(s)

Organizer

Data Source

[Presentation] Homozygous or compound heterozygous variants in DSG2 are mainly causative of Japanese arrhythmogenic right ventricular cardiomyopathy.2023

Author(s)

Organizer

Sonoda Keiko 園田桂子