Matsuoka Ken 松岡研

Researcher Number	90826190
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院生命機能研究科, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2025: 大阪大学, 大学院生命機能研究科, 准教授 2022 – 2023: 大阪大学, 大学院医学系研究科, 准教授 2022 – 2023: 大阪大学, 大学院医学系研究科, 助教 2018 – 2021: 大阪大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / 0902:General internal medicine and related fields Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 転写制御 / ナトリウム利尿ペプチド / 心不全 / エンハンサー / CR9 / 遺伝子治療 / 転写因子 Except Principal Investigator 転写機構 / 心臓 / ナトリウム利尿ペプチド遺伝子 … More / 相分離型転写ファクトリーモデル / 心臓特異的スーパーエンハンサー / 相分離型転写ファクトリー / ナトリウム利尿ペプチド / スーパーエンハンサー / 遺伝子治療 / ミトコンドリア病 / アロステリック酵素活性化剤 / 酸化的リン酸化酵素群 / 低酸素 / 心臓拡張機能 / 生活習慣病 / 微小血管障害 / G0s2 / 心臓拡張不全 / ATP / ATP合成酵素 / 微小循環障害 / ミトコンドリア / エネルギー需給バランス / 心不全 Less

心不全病態の転写制御機構の解明と治療薬開発への応用Principal Investigator
- Principal Investigator
  
  松岡研
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Osaka
心不全応答性エンハンサークラスターを用いた心臓精密遺伝子治療の開発Principal Investigator
- Principal Investigator
  
  松岡研
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
心臓特異的スーパーエンハンサーの相分離型転写ファクトリーによる転写機構の解明
- Principal Investigator
  
  塚本蔵
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Hyogo Medical University
Fundamental research for elucidation of the molecular structure mechanism of oxidative phosphorylation enzymes and development of drug discovery
- Principal Investigator
  
  Takashima Seiji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
Clarification of the transcriptional regulatory mechanism of natriuretic peptides in failing heartsPrincipal Investigator
- Principal Investigator
  
  Matsuoka Ken
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
Revealing the regulatory mechanism of the natriuretic peptides and developing the new therapy for heart failurePrincipal Investigator
- Principal Investigator
  
  Matsuoka Ken
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation Patent

[Journal Article] Association Between B-Type Natriuretic Peptide Deficiency and Left Ventricular Concentric Hypertrophy in Subclinical Individuals2024
- Author(s)
  Okamoto Chisato、Tsukamoto Osamu、Hasegawa Takuya、Matsuoka Ken、Amaki Makoto、Kanzaki Hideaki、Izumi Chisato、Takashima Seiji、Ito Shin、Kitakaze Masafumi
- Journal Title
  
  JACC: Asia
  
  Volume: 4 Issue: 1 Pages: 87-88
- DOI
  10.1016/j.jacasi.2023.10.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ1480, KAKENHI-PROJECT-23K24327
[Journal Article] Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin2023
- Author(s)
  Hitsumoto T, Tsukamoto O, Matsuoka K, Li J, Liu L, Kuramoto Y, Higo S, Ogawa S, Fujino N, Yoshida S, Kioka H, Kato H, Hakui H, Saito Y, Okamoto C, Inoue H, Hyejin J, Ueda K, Segawa T, Nishimura S, Asano Y, Asanuma H, Tani A, Imamura R, Komagawa S, Kanai T, Takamura M, Sakata Y, Kitakaze M, Haruta JI, Takashima S.
- Journal Title
  
  Circulation
  
  Volume: - Issue: 25 Pages: 1902-1918
- DOI
  10.1161/circulationaha.122.062885
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-23KJ1480, KAKENHI-PROJECT-22K12801, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-20H03927, KAKENHI-PROJECT-23K24327
[Journal Article] Gene Transfer of Skeletal Muscle-Type Myosin Light Chain Kinase via Adeno-Associated Virus 6 Improves Muscle Functions in an Amyotrophic Lateral Sclerosis Mouse Model2022
- Author(s)
  Oya Ryohei、Tsukamoto Osamu、Hitsumoto Tatsuro、Nakahara Naoya、Okamoto Chisato、Matsuoka Ken、Kato Hisakazu、Inohara Hidenori、Takashima Seiji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 3 Pages: 1747-1747
- DOI
  10.3390/ijms23031747
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17180, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-20K07338
[Journal Article] Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation2022
- Author(s)
  Hakui Hideyuki、Kioka Hidetaka、Miyashita Yohei、Nishimura Shunsuke、Matsuoka Ken、Kato Hisakazu、Tsukamoto Osamu、（3人省略）、Saito Shigeyoshi、Ohta Kunio、Asanuma Hiroshi、Fu Hai Ying、Shinomiya Haruki、Yamada Noriaki、Ohtani Tomohito、Sawa Yoshiki、Kitakaze Masafumi、Takashima Seiji、Sakata Yasushi、Asano Yoshihiro
- Journal Title
  
  Science Translational Medicine
  
  Volume: 14 Issue: 628
- DOI
  10.1126/scitranslmed.abf3274
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-21K08027, KAKENHI-PROJECT-22K08155, KAKENHI-PROJECT-21K15776, KAKENHI-PROJECT-19H03652
[Journal Article] Lower B‐type natriuretic peptide levels predict left ventricular concentric remodelling and insulin resistance2021
- Author(s)
  Okamoto Chisato、Tsukamoto Osamu、Hasegawa Takuya、Hitsumoto Tatsuro、Matsuoka Ken、Takashima Seiji、Amaki Makoto、Kanzaki Hideaki、Izumi Chisato、Ito Shin、Kitakaze Masafumi
- Journal Title
  
  ESC Heart Failure
  
  Volume: 9 Issue: 1 Pages: 636-647
- DOI
  10.1002/ehf2.13700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02914
[Journal Article] The CR9 element is a novel mechanical load‐responsive enhancer that regulates natriuretic peptide genes expression2021
- Author(s)
  Miyashita Y, Tsukamoto O, Matsuoka K, Kamikubo K, Kuramoto Y, Fu HY, Tsubota T, Hasuike H, Takayama T, Ito H, Hitsumoto T, Okamoto C, Kioka H, Oya R, Shinomiya H, Hakui H, Shintani Y, Kato H, Kitakaze M, Sakata Y, Asano Y, Takashima S
- Journal Title
  
  The FASEB Journal
  
  Volume: 35 Issue: 4
- DOI
  10.1096/fj.202002111rr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-20K17151, KAKENHI-PROJECT-19H03652
[Patent] 心不全に応答するエンハンサーポリヌクレオチド、及び前記エンハンサーポリヌクレオチドを含む発現ベクター2020
- Inventor(s)
  松岡研、高島成二
- Industrial Property Rights Holder
  松岡研、高島成二
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-20K17151
[Patent] 心不全に応答するエンハンサーポリヌクレオチド、及び前記エンハンサーポリヌクレオチドを含む発現ベクター2019
- Inventor(s)
  松岡研、高島成二
- Industrial Property Rights Holder
  松岡研、高島成二
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-206823
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K21315
[Presentation] ナトリウム利尿ペプチド遺伝子(Nppa, Nppb)の転写を調節する新規に同定した心臓特異的エンハンサーの転写環境イメージング2023
- Author(s)
  Jo Hyejin、松岡研、井上聖、塚本蔵、髙島成二
- Organizer
  第46回分子生物学会
- Data Source
  KAKENHI-PROJECT-22K08204
[Presentation] 心不全病態特異的エンハンサークラスターによるNa利尿ペプチド遺伝子の転写制御機構2023
- Author(s)
  井上聖, 松岡研, ゾ・ヘジン, 塚本蔵, 高島成二
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-23K24327
[Presentation] 心不全病態特異的エンハンサークラスターによるNa利尿ペプチド遺伝子の制御機構2023
- Author(s)
  井上聖, 松岡研, Jo Hyejin, 塚本蔵, 高島成二
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K08204
[Presentation] 胎児期及び心不全期におけるNa利尿ペプチド遺伝子の転写制御機構の解明2023
- Author(s)
  井上聖、松岡研、ゾへジン、塚本蔵、髙島成二
- Organizer
  第46回分子生物学会
- Data Source
  KAKENHI-PROJECT-22K08204
[Presentation] ナトリウム利尿ペプチドの転写を制御するエンハンサー領域と結合する転写因子群の同定2022
- Author(s)
  Jo Hyejin、松岡研、井上聖、塚本蔵、髙島成二
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K08204
[Presentation] ナトリウム利尿ペプチド遺伝子を制御する心不全感受性エンハンサークラスターの解明2022
- Author(s)
  井上聖、松岡研、ゾへジン、塚本蔵、髙島成二
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22K08204
[Presentation] ナトリウム利尿ペプチドのエンハンサー領域と転写因子群の同定2022
- Author(s)
  Jo Hyejin、松岡研、井上聖、塚本蔵、髙島成二
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K08204
[Presentation] ナトリウム利尿ペプチド遺伝子の劇的な転写誘導を行う心不全感受性エンハンサークラスターの分子機序2022
- Author(s)
  井上聖、松岡研、ゾへジン、塚本蔵、髙島成二
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K08204
[Presentation] 心臓および病態特異的エンハンサーCR9は力学的負荷で活性化されBNP発現を増加する2020
- Author(s)
  坪田朋也、松岡研、塚本蔵、高島成二
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K21315

1. Takashima Seiji (90379272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. 加藤久和 (30589312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. 塚本蔵 (80589151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. NAKAHARA Naoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 木岡秀隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Matsuoka Ken 松岡 研

Research Projects

Research Products

Co-Researchers

心不全病態の転写制御機構の解明と治療薬開発への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

心不全応答性エンハンサークラスターを用いた心臓精密遺伝子治療の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

心臓特異的スーパーエンハンサーの相分離型転写ファクトリーによる転写機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fundamental research for elucidation of the molecular structure mechanism of oxidative phosphorylation enzymes and development of drug discovery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clarification of the transcriptional regulatory mechanism of natriuretic peptides in failing heartsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Revealing the regulatory mechanism of the natriuretic peptides and developing the new therapy for heart failurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Association Between B-Type Natriuretic Peptide Deficiency and Left Ventricular Concentric Hypertrophy in Subclinical Individuals2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gene Transfer of Skeletal Muscle-Type Myosin Light Chain Kinase via Adeno-Associated Virus 6 Improves Muscle Functions in an Amyotrophic Lateral Sclerosis Mouse Model2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lower B‐type natriuretic peptide levels predict left ventricular concentric remodelling and insulin resistance2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The CR9 element is a novel mechanical load‐responsive enhancer that regulates natriuretic peptide genes expression2021

Author(s)

Journal Title

DOI

Data Source

[Patent] 心不全に応答するエンハンサーポリヌクレオチド、及び前記エンハンサーポリヌクレオチドを含む発現ベクター2020

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 心不全に応答するエンハンサーポリヌクレオチド、及び前記エンハンサーポリヌクレオチドを含む発現ベクター2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Matsuoka Ken 松岡研