Canela Andres ＣａｎｅｌａＡｎｄｒｅｓ

Researcher Number	90837585
Other IDs	https://orcid.org/0000-0002-3621-6706
Affiliation (Current)	2025: 京都大学, 生命科学研究科, 特任准教授
Affiliation (based on the past Project Information) *help	2024: 京都大学, 生命科学研究科, 特任准教授 2019 – 2023: 京都大学, 白眉センター, 特定准教授
Review Section/Research Field	Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 43050:Genome biology-related / Biological Sciences Except Principal Investigator Basic Section 49010:Pathological biochemistry-related / Medium-sized Section 63:Environmental analyses and evaluation and related fields / Medium-sized Section 57:Oral science and related fields
Keywords	Principal Investigator DNA repair / Cancer / Genome instability / Next-gen sequencing / DNA single-strand breaks / トポイソメラーゼI / DNA一本鎖切断 / TOPOISOMERASE2 / 染色体転座 / 発かん … More / ゲノム安定性 / 染色体転座発かん / DNA 二重鎖切断 / TOPOISOMERASEII / RNA polymerase 2 / DNA torsions / Chromatin loop / RNA polymerase II / DNA torsion / Transcription / DNA Topoisomerases … More Except Principal Investigator 神経炎症 / ヘテロ接合性喪失 / 遺伝性高発癌変異 / 自然発癌 / ゲノム変異解析 / ゲノム安定性 / 大腸がん / TLS DNAポリメラーゼ / 自然発がん / DNA二重鎖切断 / メダカ / DNA修復酵素 / 発がん / ゲノム構造変異 / ゲノム不安定性 / 再生効果 / 遺伝子発現 / 歯周組織再生 / 数理モデル / 再生機構 / 歯周組織 Less

アストロサイト形質転換の分子機序解明と創薬標的の探索
- Principal Investigator
  
  小林亜希子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kyoto University
Development of a methodology to map and quantify in the genome DNA single strand breaks.Principal Investigator
- Principal Investigator
  
  Canela Andres
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kyoto University
Regulation of Genome Stability in Medaka
- Principal Investigator
  
  Todo Takeshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  Osaka University
Elucidation of mechanisms of regeneration of periodontal tissue by mathematical modelling
- Principal Investigator
  
  Fujihara Chiharu
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Osaka University
Role of DNA topology in gene expression.Principal Investigator
- Principal Investigator
  
  Canela Andres
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Genome organization as a source of chromosomal instability in cancer.Principal Investigator
- Principal Investigator
  
  Canela Andres
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43050:Genome biology-related
- Research Institution
  Kyoto University

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Neuronal enhancers are hotspots for DNA single-strand break repair.2021
- Author(s)
  Wu W, Hill SE, Nathan WJ, Paiano J, Callen E, Wang D, Shinoda K, van Wietmarschen N, Colon-Mercado JM, Zong D, De Pace R, Shih HY, Coon S, Parsadanian M, Pavani R, Hanzlikova H, Park S, Jung SK, McHugh PJ, Canela A, Chen C, Casellas R, Caldecott KW, Ward ME, Nussenzweig A.
- Journal Title
  
  Nature
  
  Volume: online Issue: 7859 Pages: 440-444
- DOI
  10.1038/s41586-021-03468-5
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21393, KAKENHI-PUBLICLY-19H05261, KAKENHI-PROJECT-19H03208
[Journal Article] END-seq: An Unbiased, High-Resolution, and Genome-Wide Approach to Map DNA Double-Strand Breaks and Resection in Human Cells2021
- Author(s)
  Wong N, John S, Nussenzweig A, Canela A.
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 2153 Pages: 9-31
- DOI
  10.1007/978-1-0716-0644-5_2
- ISBN
  9781071606438, 9781071606445
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21393, KAKENHI-PUBLICLY-19H05261, KAKENHI-PROJECT-19H03208
[Journal Article] Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes2021
- Author(s)
  Huang SN, Michaels SA, Mitchell BB, Majdalani N, Vanden Broeck A, Canela A, Tse-Dinh YC, Lamour V, Pommier Y.
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 10
- DOI
  10.1126/sciadv.abe0384
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21393, KAKENHI-PUBLICLY-19H05261, KAKENHI-PROJECT-19H03208, KAKENHI-PROJECT-20H00631
[Journal Article] 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.2020
- Author(s)
  Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, Pavani R, Dumitrache LC, Byrum AK, Mendez-Dorantes C, Martinez P, Canela A, Maman Y, Day A, Kruhlak MJ, Blasco MA, Stark JM, Mosammaparast N, McKinnon PJ, Nussenzweig A
- Journal Title
  
  Molecular Cell
  
  Volume: 77 Issue: 1 Pages: 26-38
- DOI
  10.1016/j.molcel.2019.09.024
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05261, KAKENHI-PROJECT-19H03208
[Journal Article] Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.2019
- Author(s)
  Canela A, Maman Y, Huang SN, Wutz G, Tang W, Zagnoli-Vieira G, Callen E, Wong N, Day A, Peters JM, Caldecott KW, Pommier Y, Nussenzweig A
- Journal Title
  
  Molecular Cell
  
  Volume: 75 Issue: 2 Pages: 252-266
- DOI
  10.1016/j.molcel.2019.04.030
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05261, KAKENHI-PROJECT-19H03208
[Journal Article] Intra-V? Cluster Recombination Shapes the Ig Kappa Locus Repertoire2019
- Author(s)
  Shinoda K, Maman Y, Canela A, Schatz DG, Livak F, Nussenzweig A
- Journal Title
  
  Cell Reports
  
  Volume: 29 Issue: 13 Pages: 4471-4481
- DOI
  10.1016/j.celrep.2019.11.088
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05261, KAKENHI-PROJECT-19H03208
[Presentation] 高発がんメダカrev3l変異体のがんゲノム解析2022
- Author(s)
  藤原智子, 藤川芳宏, カネラ・アンドレス, 庄司竜麻, 孫菲, 瀬々潤, 藤堂剛
- Organizer
  放射線影響学会65回大会
- Data Source
  KAKENHI-PROJECT-20H00631
[Presentation] Genome instability of tumor prone rev3l deficient medaka mutant2021
- Author(s)
  Tomoko Ishikawa-Fujiwara, Yoshihiro Fujikawa, Andres Canela, Tatsuma Shoji, Fei Sun,　Jun Sese, Takeshi Todo
- Organizer
  日本放射線影響学会第64回大会
- Data Source
  KAKENHI-PROJECT-20H00631
[Presentation] How to find breaks in the DNA and what they can tell us about genome organization2020
- Author(s)
  Andres Canela
- Organizer
  Central Dogma Seminar. Graduate School of Biostudies. Kyoto University
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05261
[Presentation] Genome analysis of Rev3l deficient medaka mutant.2020
- Author(s)
  Tomoko (Ishikawa) Fujiwara, Yoshihiro Fujikawa, Andres Canela, Tatsuma Shoji, Fei Sun, Jun Sese, Takeshi Todo
- Organizer
  日本放射線影響学会第63回大会
- Data Source
  KAKENHI-PROJECT-20H00631
[Presentation] How to find breaks in the DNA and what they can tell us about genome organization2020
- Author(s)
  Andres Canela
- Organizer
  Central Dogma Seminar. Graduate School of Biostudies. Kyoto University
- Invited
- Data Source
  KAKENHI-PROJECT-19H03208
[Presentation] Topoisomerase II-induced chromosome breakage and translocation is determined by chromosome architecture and transcriptional activity.2019
- Author(s)
  Andres Canela
- Organizer
  EMBO Workshop: Organization of bacterial and eukaryotic genomes by SMC complexes. Vienna, Austria
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03208
[Presentation] Topoisomerase II-induced chromosome breakage and translocation is determined by chromosome architecture and transcriptional activity.2019
- Author(s)
  Andres Canela
- Organizer
  EMBO Workshop: DNA topology and topoisomerases in genome dynamics. Les Diablerets, Switzerland
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03208
[Presentation] Genome folding as a source of DNA damage and tumorigenesis2019
- Author(s)
  Andres Canela
- Organizer
  21st Symposium of Graduate School of Biostudies. Kyoto University
- Invited
- Data Source
  KAKENHI-PROJECT-19H03208
[Presentation] Topoisomerase II-induced chromosome breakage and translocation is determined by chromosome architecture and transcriptional activity.2019
- Author(s)
  Andres Canela
- Organizer
  EMBO Workshop: DNA topology and topoisomerases in genome dynamics. Les Diablerets, Switzerland
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05261
[Presentation] Genome folding as a source of DNA damage and tumorigenesis2019
- Author(s)
  Andres Canela
- Organizer
  21st Symposium of Graduate School of Biostudies. Kyoto University
- Invited
- Data Source
  KAKENHI-PUBLICLY-19H05261
[Presentation] Topoisomerase II-induced chromosome breakage and translocation is determined by chromosome architecture and transcriptional activity.2019
- Author(s)
  Andres Canela
- Organizer
  EMBO Workshop: Organization of bacterial and eukaryotic genomes by SMC complexes. Vienna, Austria
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-19H05261

1. Fujihara Chiharu (00755358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. Todo Takeshi (90163948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 北村正博 (10243247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 竹立匡秀 (60452447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 吉村崇 (90323336)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 瀬々潤 (40361539)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. 小林亜希子 (80649046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Canela Andres Ｃａｎｅｌａ Ａｎｄｒｅｓ

Research Projects

Research Products

Co-Researchers

アストロサイト形質転換の分子機序解明と創薬標的の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a methodology to map and quantify in the genome DNA single strand breaks.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of Genome Stability in Medaka

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanisms of regeneration of periodontal tissue by mathematical modelling

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of DNA topology in gene expression.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Genome organization as a source of chromosomal instability in cancer.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Neuronal enhancers are hotspots for DNA single-strand break repair.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] END-seq: An Unbiased, High-Resolution, and Genome-Wide Approach to Map DNA Double-Strand Breaks and Resection in Human Cells2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intra-V? Cluster Recombination Shapes the Ig Kappa Locus Repertoire2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 高発がんメダカrev3l変異体のがんゲノム解析2022

Author(s)

Organizer

Data Source

[Presentation] Genome instability of tumor prone rev3l deficient medaka mutant2021

Author(s)

Organizer

Data Source

[Presentation] How to find breaks in the DNA and what they can tell us about genome organization2020

Canela Andres ＣａｎｅｌａＡｎｄｒｅｓ