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Canela Andres  Canela Andres

Researcher Number 90837585
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-3621-6706
Affiliation (Current) 2025: 京都大学, 生命科学研究科, 特任准教授
Affiliation (based on the past Project Information) *help 2024: 京都大学, 生命科学研究科, 特任准教授
2019 – 2023: 京都大学, 白眉センター, 特定准教授
Review Section/Research Field
Principal Investigator
Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 43050:Genome biology-related / Biological Sciences
Except Principal Investigator
Basic Section 49010:Pathological biochemistry-related / Medium-sized Section 63:Environmental analyses and evaluation and related fields / Medium-sized Section 57:Oral science and related fields
Keywords
Principal Investigator
DNA repair / Cancer / Genome instability / Next-gen sequencing / DNA single-strand breaks / トポイソメラーゼI / DNA一本鎖切断 / TOPOISOMERASE2 / 染色体転座 / 発かん … More / ゲノム安定性 / 染色体転座発かん / DNA 二重鎖切断 / TOPOISOMERASEII / RNA polymerase 2 / DNA torsions / Chromatin loop / RNA polymerase II / DNA torsion / Transcription / DNA Topoisomerases … More
Except Principal Investigator
神経炎症 / ヘテロ接合性喪失 / 遺伝性高発癌変異 / 自然発癌 / ゲノム変異解析 / ゲノム安定性 / 大腸がん / TLS DNAポリメラーゼ / 自然発がん / DNA二重鎖切断 / メダカ / DNA修復酵素 / 発がん / ゲノム構造変異 / ゲノム不安定性 / 再生効果 / 遺伝子発現 / 歯周組織再生 / 数理モデル / 再生機構 / 歯周組織 Less
  • Research Projects

    (6 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (7 People)
  •  アストロサイト形質転換の分子機序解明と創薬標的の探索

    • Principal Investigator
      小林 亜希子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Kyoto University
  •  Development of a methodology to map and quantify in the genome DNA single strand breaks.Principal Investigator

    • Principal Investigator
      Canela Andres
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      Kyoto University
  •  Regulation of Genome Stability in Medaka

    • Principal Investigator
      Todo Takeshi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 63:Environmental analyses and evaluation and related fields
    • Research Institution
      Osaka University
  •  Elucidation of mechanisms of regeneration of periodontal tissue by mathematical modelling

    • Principal Investigator
      Fujihara Chiharu
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 57:Oral science and related fields
    • Research Institution
      Osaka University
  •  Role of DNA topology in gene expression.Principal Investigator

    • Principal Investigator
      Canela Andres
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Genome organization as a source of chromosomal instability in cancer.Principal Investigator

    • Principal Investigator
      Canela Andres
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 43050:Genome biology-related
    • Research Institution
      Kyoto University

All 2022 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] Neuronal enhancers are hotspots for DNA single-strand break repair.2021

    • Author(s)
      Wu W, Hill SE, Nathan WJ, Paiano J, Callen E, Wang D, Shinoda K, van Wietmarschen N, Colon-Mercado JM, Zong D, De Pace R, Shih HY, Coon S, Parsadanian M, Pavani R, Hanzlikova H, Park S, Jung SK, McHugh PJ, Canela A, Chen C, Casellas R, Caldecott KW, Ward ME, Nussenzweig A.
    • Journal Title

      Nature

      Volume: online Issue: 7859 Pages: 440-444

    • DOI

      10.1038/s41586-021-03468-5

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21393, KAKENHI-PUBLICLY-19H05261, KAKENHI-PROJECT-19H03208
  • [Journal Article] END-seq: An Unbiased, High-Resolution, and Genome-Wide Approach to Map DNA Double-Strand Breaks and Resection in Human Cells2021

    • Author(s)
      Wong N, John S, Nussenzweig A, Canela A.
    • Journal Title

      Methods in Molecular Biology

      Volume: 2153 Pages: 9-31

    • DOI

      10.1007/978-1-0716-0644-5_2

    • ISBN
      9781071606438, 9781071606445
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21393, KAKENHI-PUBLICLY-19H05261, KAKENHI-PROJECT-19H03208
  • [Journal Article] Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes2021

    • Author(s)
      Huang SN, Michaels SA, Mitchell BB, Majdalani N, Vanden Broeck A, Canela A, Tse-Dinh YC, Lamour V, Pommier Y.
    • Journal Title

      Science Advances

      Volume: 7 Issue: 10

    • DOI

      10.1126/sciadv.abe0384

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21393, KAKENHI-PUBLICLY-19H05261, KAKENHI-PROJECT-19H03208, KAKENHI-PROJECT-20H00631
  • [Journal Article] 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination.2020

    • Author(s)
      Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, Pavani R, Dumitrache LC, Byrum AK, Mendez-Dorantes C, Martinez P, Canela A, Maman Y, Day A, Kruhlak MJ, Blasco MA, Stark JM, Mosammaparast N, McKinnon PJ, Nussenzweig A
    • Journal Title

      Molecular Cell

      Volume: 77 Issue: 1 Pages: 26-38

    • DOI

      10.1016/j.molcel.2019.09.024

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-19H05261, KAKENHI-PROJECT-19H03208
  • [Journal Article] Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity.2019

    • Author(s)
      Canela A, Maman Y, Huang SN, Wutz G, Tang W, Zagnoli-Vieira G, Callen E, Wong N, Day A, Peters JM, Caldecott KW, Pommier Y, Nussenzweig A
    • Journal Title

      Molecular Cell

      Volume: 75 Issue: 2 Pages: 252-266

    • DOI

      10.1016/j.molcel.2019.04.030

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-19H05261, KAKENHI-PROJECT-19H03208
  • [Journal Article] Intra-V? Cluster Recombination Shapes the Ig Kappa Locus Repertoire2019

    • Author(s)
      Shinoda K, Maman Y, Canela A, Schatz DG, Livak F, Nussenzweig A
    • Journal Title

      Cell Reports

      Volume: 29 Issue: 13 Pages: 4471-4481

    • DOI

      10.1016/j.celrep.2019.11.088

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-19H05261, KAKENHI-PROJECT-19H03208
  • [Presentation] 高発がんメダカrev3l変異体のがんゲノム解析2022

    • Author(s)
      藤原智子, 藤川芳宏, カネラ・アンドレス, 庄司竜麻, 孫菲, 瀬々潤, 藤堂剛
    • Organizer
      放射線影響学会65回大会
    • Data Source
      KAKENHI-PROJECT-20H00631
  • [Presentation] Genome instability of tumor prone rev3l deficient medaka mutant2021

    • Author(s)
      Tomoko Ishikawa-Fujiwara, Yoshihiro Fujikawa, Andres Canela, Tatsuma Shoji, Fei Sun, Jun Sese, Takeshi Todo
    • Organizer
      日本放射線影響学会第64回大会
    • Data Source
      KAKENHI-PROJECT-20H00631
  • [Presentation] How to find breaks in the DNA and what they can tell us about genome organization2020

    • Author(s)
      Andres Canela
    • Organizer
      Central Dogma Seminar. Graduate School of Biostudies. Kyoto University
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-19H05261
  • [Presentation] Genome analysis of Rev3l deficient medaka mutant.2020

    • Author(s)
      Tomoko (Ishikawa) Fujiwara, Yoshihiro Fujikawa, Andres Canela, Tatsuma Shoji, Fei Sun, Jun Sese, Takeshi Todo
    • Organizer
      日本放射線影響学会第63回大会
    • Data Source
      KAKENHI-PROJECT-20H00631
  • [Presentation] How to find breaks in the DNA and what they can tell us about genome organization2020

    • Author(s)
      Andres Canela
    • Organizer
      Central Dogma Seminar. Graduate School of Biostudies. Kyoto University
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03208
  • [Presentation] Topoisomerase II-induced chromosome breakage and translocation is determined by chromosome architecture and transcriptional activity.2019

    • Author(s)
      Andres Canela
    • Organizer
      EMBO Workshop: Organization of bacterial and eukaryotic genomes by SMC complexes. Vienna, Austria
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03208
  • [Presentation] Topoisomerase II-induced chromosome breakage and translocation is determined by chromosome architecture and transcriptional activity.2019

    • Author(s)
      Andres Canela
    • Organizer
      EMBO Workshop: DNA topology and topoisomerases in genome dynamics. Les Diablerets, Switzerland
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03208
  • [Presentation] Genome folding as a source of DNA damage and tumorigenesis2019

    • Author(s)
      Andres Canela
    • Organizer
      21st Symposium of Graduate School of Biostudies. Kyoto University
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03208
  • [Presentation] Topoisomerase II-induced chromosome breakage and translocation is determined by chromosome architecture and transcriptional activity.2019

    • Author(s)
      Andres Canela
    • Organizer
      EMBO Workshop: DNA topology and topoisomerases in genome dynamics. Les Diablerets, Switzerland
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-19H05261
  • [Presentation] Genome folding as a source of DNA damage and tumorigenesis2019

    • Author(s)
      Andres Canela
    • Organizer
      21st Symposium of Graduate School of Biostudies. Kyoto University
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-19H05261
  • [Presentation] Topoisomerase II-induced chromosome breakage and translocation is determined by chromosome architecture and transcriptional activity.2019

    • Author(s)
      Andres Canela
    • Organizer
      EMBO Workshop: Organization of bacterial and eukaryotic genomes by SMC complexes. Vienna, Austria
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-19H05261
  • 1.  Fujihara Chiharu (00755358)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  Todo Takeshi (90163948)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 3.  北村 正博 (10243247)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  竹立 匡秀 (60452447)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  吉村 崇 (90323336)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  瀬々 潤 (40361539)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  小林 亜希子 (80649046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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