Shigeta Shogo 重田昌吾

Researcher Number	90842633
Other IDs
Affiliation (Current)	2026: 東北大学, 医学系研究科, 准教授
Affiliation (based on the past Project Information) *help	2026: 東北大学, 医学系研究科, 准教授 2024: 東北大学, 医学系研究科, 准教授 2022 – 2023: 東北大学, 大学病院, 講師 2021 – 2023: 東北大学, 医学系研究科, 助教 2020: 東北大学, 医学系研究科, 大学院非常勤講師 2019: 東北大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 56040:Obstetrics and gynecology-related / 0901:Oncology and related fields Except Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Basic Section 58080:Gerontological nursing and community health nursing-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator 卵巣明細胞癌 / エピゲノム / 個別化医療 / マルチオミックス / プロテオーム / メタボローム / 全ゲノム解析 / 全エクソーム解析 / セラミド / スフィンゴ脂質 … More / メタボローム解析 / 婦人科癌 / SWI/SNF / 凝固 / ARID1A / BAZ2A / EZH2 / 婦人科悪性腫瘍 / オルガノイド / ブロモドメイン / 癌オルガノイド / 明細胞癌 / 卵巣癌 … More Except Principal Investigator 卵巣癌 / セラミド / ネクロプトーシス / 難治性がん / 白金製剤 / フェロトーシス / 皮膚虚血再灌流障害 / がん / 脂質生物学 / スフィンゴ脂質 / MLKL / ネクロトーシス / シスプラチン / 抗がん薬 / 細胞死 / 白金抵抗性 / 明細胞癌 / 卵巣がん / メタボローム / クロマチンリモデリング / 薬剤耐性 / 鑑別診断 / 難治性 / 化学療法抵抗性 / 粘液性癌 / 難治性癌 / プロテオーム解析 / オミックス解析 / 多層的オミックス解析 / メタボローム解析 / 婦人科難治性希少がん / 卵巣粘液性癌 / プラチナ耐性 / オルガノイドモデル / プラチナ感受性 / オルガノイド / CHD4 / 治療抵抗性 Less

スフィンゴ脂質代謝と腫瘍微小環境の関連解析に基づく新規治療開発Principal Investigator
- Principal Investigator
  
  重田昌吾
- Project Period (FY)
  2026 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku University
上皮性卵巣癌におけるネクロプトーシスの臨床的意義と治療標的としての可能性
- Principal Investigator
  
  橋本千明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Tohoku University
フェロミクス解析を用いた褥瘡形成における鉄の病態生理学的役割の解明
- Principal Investigator
  
  西田健太朗
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 58080:Gerontological nursing and community health nursing-related
- Research Institution
  Setsunan University
A multi-omics investigation of novel therapeutic strategies for clear cell carcinoma of the ovary focusing on cancer metabolismPrincipal Investigator
- Principal Investigator
  
  重田昌吾
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku University
Regulation of necroptosis by lipids and ceramide recognition
- Principal Investigator
  
  Kitatani Kazuyuki
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Setsunan University
Development of a New Treatment Strategy for Refractory Ovarian Mucinous Carcinoma
- Principal Investigator
  
  SHIMADA Muneaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Tohoku University
Elucidation of the mechanism of drug resistance in ovarian cancer with poor prognosis and development of new therapeutic targets
- Principal Investigator
  
  TOKUNAGA Hideki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Tohoku University
Targeting epigenetic regulators as a novel combination therapy for gynecologic malignancies harboring SWI/SNF alteration.Principal Investigator
- Principal Investigator
  
  Shigeta Shogo
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Tohoku University
An investigation of novel therapeutic strategies for platinum-resistant ovarian cancer using cancer organoid originated from disseminating ovarian carcinoma
- Principal Investigator
  
  TSUJI Keita
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Tohoku University
Targeting bromodomains as a novel therapeutic strategy for clear cell carcinoma of the ovary.Principal Investigator
- Principal Investigator
  
  Shigeta Shogo
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Identification of predictive biomarkers for diagnosis and radiation sensitivity of uterine cervical cancer using wide‐targeted metabolomics2023
- Author(s)
  Hishinuma Eiji、Shimada Muneaki、Matsukawa Naomi、Li Bin、Motoike Ikuko N.、Hagihara Tatsuya、Shigeta Shogo、Tokunaga Hideki、Saigusa Daisuke、Kinoshita Kengo、Koshiba Seizo、Yaegashi Nobuo
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 49 Issue: 8 Pages: 2109-2117
- DOI
  10.1111/jog.15709
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09486, KAKENHI-PROJECT-21K09531, KAKENHI-PROJECT-23K24478, KAKENHI-PROJECT-23K27316
[Journal Article] Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling2023
- Author(s)
  Hishinuma Eiji、Shimada Muneaki、Matsukawa Naomi、Shima Yoshiko、Li Bin、Motoike Ikuko N.、Shibuya Yusuke、Hagihara Tatsuya、Shigeta Shogo、Tokunaga Hideki、Saigusa Daisuke、Kinoshita Kengo、Koshiba Seizo、Yaegashi Nobuo
- Journal Title
  
  Cancer & Metabolism
  
  Volume: 11 Issue: 1
- DOI
  10.1186/s40170-023-00317-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09486, KAKENHI-PROJECT-21K09531, KAKENHI-PROJECT-23K24478, KAKENHI-PROJECT-23K27316
[Journal Article] An Attempt to Develop a New Treatment Strategy for Rare Refractory Gynecological Malignancies: The Japanese Gynecologic Oncology Group2023
- Author(s)
  Shigeta S, Shimada M, Suzuki S, Kajiyama H, Oda K, Takehara K, Mandai M, Aoki D, Enomoto T, Okamoto A.
- Journal Title
  
  JMA Journal
  
  Volume: 6 Issue: 4 Pages: 527-531
- DOI
  10.31662/jmaj.2023-0024
- ISSN
  2433-328X, 2433-3298
- Year and Date
  2023-10-16
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09486, KAKENHI-PROJECT-21H03074, KAKENHI-PROJECT-23K21473
[Journal Article] Comparison of treatment outcomes between first-line chemotherapy with or without bevacizumab for advanced ovarian, fallopian tube, and primary peritoneal cancer (Tohoku gynecologic cancer unit: TGCU-RS001 study)2022
- Author(s)
  Takatori E, Nagasawa T, Kagabu M, Baba T, Shigeto T, Matsumura Y, Shimizu D, Terada Y, Seino M, Ohta T, Nagase S, Shigeta S, Tokunaga H, Shimada M, Kaiho-Sakuma M, Furukawa S, Soeda S, Watanabe T, Takahashi F, Yokoyama Y.
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 27 Issue: 12 Pages: 1874-1880
- DOI
  10.1007/s10147-022-02246-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09531, KAKENHI-PROJECT-21K09548
[Journal Article] A Retrospective Analysis of Clinical Biomarkers for Olaparib Maintenance Therapy in Patients with Recurrent Ovarian Cancer2022
- Author(s)
  Endo Shun、Shigeta Shogo、Tokunaga Hideki、Shimizu Takanori、Hasegawa-Minato Junko、Hashimoto Chiaki、Ishibashi Masumi、Nagai Tomoyuki、Shiga Naomi、Shimada Muneaki、Yaegashi Nobuo
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 258 Issue: 1 Pages: 1-9
- DOI
  10.1620/tjem.2022.J050
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09531
[Journal Article] CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents.2021
- Author(s)
  Oyama Y, Shigeta S, Tokunaga H, Tsuji K, Ishibashi M, Shibuya Y, Shimada M, Yasuda J, Yaegashi N.
- Journal Title
  
  PLoS One.
  
  Volume: 16(6) Issue: 6 Pages: 0251079-0251079
- DOI
  10.1371/journal.pone.0251079
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03795, KAKENHI-PROJECT-19K09747, KAKENHI-PROJECT-21K09531, KAKENHI-PROJECT-20K18211
[Journal Article] Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer2021
- Author(s)
  Hishinuma E, Shimada M, Matsukawa N, Saigusa D, Li B, Kudo K, Tsuji K, Shigeta S, Tokunaga H, Kumada K, Komine K, Shirota H, Aoki Y, Motoike IN, Yasuda J, Kinoshita K, Yamamoto M, Koshiba S, Yaegashi N.
- Journal Title
  
  Toxins (Basel).
  
  Volume: 13 Issue: 7 Pages: 461-461
- DOI
  10.3390/toxins13070461
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07657, KAKENHI-PROJECT-19H03795, KAKENHI-PROJECT-21K09486, KAKENHI-PROJECT-21K09531
[Presentation] 血中代謝産物に着目した経時的リキッドバイオプシーによる進行再発卵巣癌モニタリング法の開発2024
- Author(s)
  重田昌吾　菱沼英史、島田宗昭、渋谷祐介、湊敬道、安田純、清水孝規、宮原周子、湊純子、橋本千明、石橋ますみ、徳永英樹、八重樫伸生
- Organizer
  第66回日本婦人科腫瘍学会
- Data Source
  KAKENHI-PROJECT-23K06688
[Presentation] Sequential Plasma Metabolome Analysis for Monitoring Therapeutic Response in Ovarian Cancer2024
- Author(s)
  Shogo Shigeta, Eiji Hishinuma, Naomi Natsukawa, Yusuke Shibuya, Muneaki Shimada
- Organizer
  Asian Society of Gynecologic Oncology 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06688
[Presentation] 多角的研究基盤を統合した探索的研究に基づく卵巣明細胞癌の新規個別化医療開発2024
- Author(s)
  重田昌吾
- Organizer
  第76回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-23K06688
[Presentation] FDAの動物実験義務化撤廃と医学研究における動物実験の代替手段について2023
- Author(s)
  重田　昌吾
- Organizer
  第20回　婦人科がん会議
- Invited
- Data Source
  KAKENHI-PROJECT-20K18211
[Presentation] 子宮体癌における血漿メタボローム解析による新規バイオマーカーの探索2023
- Author(s)
  萩原達也，島田宗昭, 菱沼英史, 李　賓, 橋本栄文, 栃木実佳子, 遠藤　俊, 清水孝規, 湊　純子, 渋谷祐介, 橋本千明, 石橋ますみ, 重田昌吾, 徳永英樹, 八重樫伸生
- Organizer
  第65回日本婦人科腫瘍学会　高得点演題
- Data Source
  KAKENHI-PROJECT-21K09486
[Presentation] 当院における遺伝性乳癌卵巣癌症候群に対するリスク低減卵管卵巣摘出術の経験2022
- Author(s)
  湊純子，島田宗昭, 萩原達也, 橋本栄文, 湊敬道, 橋本千明, 石橋ますみ, 重田昌吾, 永井智之, 徳永英樹, 八重樫伸生
- Organizer
  第74回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-21K09531
[Presentation] リスク低減卵管卵巣摘出術待機中にIIIA1(ii)期の卵管癌を発症した遺伝性乳癌卵巣癌症候群の一例2022
- Author(s)
  村川真理弥，湊純子, 熊谷奈津美, 萩原達也, 橋本栄文, 高橋友梨, 栃木実佳子, 橋本千明, 石橋ますみ, 重田昌吾, 永井智之, 徳永英樹, 島田宗昭, 八重樫伸生
- Organizer
  第151回東北連合産科婦人科学会総会
- Data Source
  KAKENHI-PROJECT-21K09531
[Presentation] チロシンキナーゼ受容体型蛋白TIE-1の卵巣癌に対する抗腫瘍効果の検討2022
- Author(s)
  石橋ますみ，徳永英樹, 重田昌吾, 永井智之, 島田宗昭, 八重樫伸生
- Organizer
  第64回日本婦人科腫瘍学会
- Data Source
  KAKENHI-PROJECT-21K09531
[Presentation] 進行卵巣癌における初回化学療法後の維持療法選択に関する後方視的検討2022
- Author(s)
  橋本栄文，萩原達也, 遠藤俊, 清水孝規, 湊敬道, 湊純子, 橋本千明, 石橋ますみ, 重田昌吾, 徳永英樹, 島田宗昭, 八重樫伸生
- Organizer
  第74回日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-21K09531
[Presentation] 卵巣癌既発症のBRCA病的バリアント保持者に対する乳房サーベイランスの現状2022
- Author(s)
  湊純子，島田宗昭, 橋本栄文, 萩原達也, 湊敬道, 橋本千明, 石橋ますみ, 重田昌吾, 永井智之, 徳永英樹, 八重樫伸生
- Organizer
  第64回日本婦人科腫瘍学会
- Data Source
  KAKENHI-PROJECT-21K09531
[Presentation] ブロモドメインを中心とした卵巣明細胞癌に対する新規個別化医療確立に向けた橋渡し研究2021
- Author(s)
  重田　昌吾
- Organizer
  第63回　日本婦人科腫瘍学会学術講演会　公募シンポジウム
- Data Source
  KAKENHI-PROJECT-20K18211
[Presentation] Functional analysis of ZFHX4 as a novel therapeutic target in ovarian cancer2020
- Author(s)
  Yoshiko Oyama, Shigeta Shogo, Keita Tsuji, Muneaki Shimada, Nobuo Yaegashi
- Organizer
  American Association for cancer research Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09747
[Presentation] RNAi及び薬剤スクリーニングを用いた卵巣明細胞癌に対する新規治療標的分子の同定2020
- Author(s)
  重田　昌吾, Christopher Kemp, 八重樫　伸生
- Organizer
  第８回　婦人科がんバイオマーカー研究会学術集会
- Data Source
  KAKENHI-PROJECT-19K23904
[Presentation] Functional analysis of ZFHX4 as a novel therapeutic target in ovarian cancer2020
- Author(s)
  Yoshiko Oyama, Shogo Shigeta, Keita Tsuji, Hideki Tokunaga, Muneaki Shimada, Nobuo Yaegashi
- Organizer
  AACR Virtual Annual Meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23904

1. SHIMADA Muneaki (40362892)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
2. TOKUNAGA Hideki (30595559)

# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
3. Kitatani Kazuyuki (40539235)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. TSUJI Keita (10835341)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 伊藤潔 (50201926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 菱沼英史 (10824609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 橋本千明 (50821625)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 石橋ますみ (20821383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 西田健太朗 (20533805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 安田純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 八重樫伸生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 城田英和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shigeta Shogo 重田 昌吾

Research Projects

Research Products

Co-Researchers

スフィンゴ脂質代謝と腫瘍微小環境の関連解析に基づく新規治療開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

上皮性卵巣癌におけるネクロプトーシスの臨床的意義と治療標的としての可能性

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

フェロミクス解析を用いた褥瘡形成における鉄の病態生理学的役割の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A multi-omics investigation of novel therapeutic strategies for clear cell carcinoma of the ovary focusing on cancer metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of necroptosis by lipids and ceramide recognition

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a New Treatment Strategy for Refractory Ovarian Mucinous Carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of drug resistance in ovarian cancer with poor prognosis and development of new therapeutic targets

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting epigenetic regulators as a novel combination therapy for gynecologic malignancies harboring SWI/SNF alteration.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

An investigation of novel therapeutic strategies for platinum-resistant ovarian cancer using cancer organoid originated from disseminating ovarian carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting bromodomains as a novel therapeutic strategy for clear cell carcinoma of the ovary.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Identification of predictive biomarkers for diagnosis and radiation sensitivity of uterine cervical cancer using wide‐targeted metabolomics2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An Attempt to Develop a New Treatment Strategy for Rare Refractory Gynecological Malignancies: The Japanese Gynecologic Oncology Group2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Shigeta Shogo 重田昌吾