KOMIYAMA Kanki 小宮山寛機

… Alternative Names

小宮山寛機コミヤマカンキ

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Researcher Number	00106676
Other IDs
Affiliation (based on the past Project Information) *help	2008: 北里大学, 基礎研究所, 所長 2006 – 2007: 北里研究所, 臨床薬理研究所, 部長 2004: 社団法人北里研究所, 臨床薬理研究所, 部長 2003: 北里研究所, 副部長 2003: Kitasato Institute, Pharmacology, Vice President, 臨床薬理研究所, 副部長 … More 2003: 社団法人北里研究所, 臨床薬理研究所, 部長 2002: 北里研究所, 臨床薬理研究所, 副所長 2002: 社団法人北里研究所, 臨床薬理研究所, 副所長 2001: 社団法人北里研究所, 臨床薬理研究所, 副所長 2000: 社団法人北里研究所, 臨床薬理研究所, 副所長 1999: 社団法人北里研究所, 基礎研究所, 部長 1997: 北里研究所, 基礎研究所, 所長 1996: (社)北里研究所, 基礎研, 副所長 1994: 北里研究所, 基礎研, 副所長 1993: 北里研究所, 研究部, 次長 1990 – 1992: 北里研究所, 研究部, 室長 1987: 北里研, 室長 1986: 北里研究所, 室長 Less
Review Section/Research Field	Principal Investigator Biological Sciences Except Principal Investigator 医薬分子機能学 / Applied pharmacology
Keywords	Principal Investigator ブフォゲニン / イソプレノイド / インドールアルカロイド / 悪液質 / 天然物 / センソ / がん性悪疫質 / 耐性克服 / がん悪液質 / 多剤耐性 … More / がん / IL-6 / TRAIL / 癌性悪液質 / 薬剤耐性 / MH60 / P-glycoprotein / CD6 / CD4 / FO-7711 / 多剤耐性克服 / QOL / IL-6阻害 / VEGF / E-selectin / SLe^x / 肺転移 / BL6 melanoma / B16 / Str.TI / 血管新生阻害 / macrosphelide / 細胞接着阻害 … More Except Principal Investigator 血管新生 / 情報伝達系 / 制癌物質 / 転移 / サフラマイシン / アポトーシス / がん抑制遺伝子 / シグナル伝達 / がん遺伝子 / 血小板産生 / 癌抑制遺伝子 / 耐性克服 / サイトカイン誘導 / Clinical trial / Signal transduction / Mechanical effect / Selective inhibitor / Functional mediator / Natural compound / Anti-allergic compound / Anti-inflammatory drug / 臨床応用 / 作用メカニズム / 選択的阻害 / 特異受容体 / 天然化合物 / 抗アレルギー剤 / 抗炎症剤 / 低毒性アンスラサイクリン / バクトボリン / アスカマイシン,スタボマイシン / 癌細胞の薬剤耐性機構 / モルフオリノロドロキシカルミノマイシン / リゾキシン / ゲニスチン / スタボマイシン / アスカマイシン / 薬剤耐性癌細胞 / アンスラサイクリン誘導体 / 抗癌剤の心毒性 / 天然物質 / 天然由来物質 / TRAIL / 分子標的薬 / 成人T細胞白血病・リンパ腫 / 分子標的治療 / 接着 / 転写因子 / がん転移 / マクロライド / チロシンキナーゼ阻害剤 / 細胞周期 / がん化シグナル / Ets-1 / CDKインヒビター / cyclin D1 / p21^<waf1> / RB / 細胞接着 / Ablチロシンキナーゼ / Srcチロシンキナーゼ / p7056キナーゼ / MAPキナーゼ / Srcがん遺伝子 / Rasがん遺伝子 / U0126 / スクリーニング / 足場非依存性増殖 / 制がん剤 / 薬剤耐性 / IL-6 / 制がん物質 / 細胞外マトリックス / 活性化酸素 Less

Natural compounds that enhance TRAIL-induced apoptosis : a novel molecular targeted cancer therapy
- Principal Investigator
  
  HASEGAWA Hiroo
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Nagasaki University
Studies on the biochemical characterization of specific mediators for anti-inflammatory and anti-allergic compounds
- Principal Investigator
  
  OHTSUKI Kenzo
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  KITASATO UNIVERSITY
天然由来抗腫瘍性物質の開拓と病態解析への応用Principal Investigator
- Principal Investigator
  
  小宮山寛機
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kitasato Institute
天然より得られた抗腫瘍物質の作用機序解析と実験病態モデルでの評価Principal Investigator
- Principal Investigator
  
  小宮山寛機
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kitasato Institute
細胞がん化のシグナル伝達の解析と特異的阻害剤の探索
- Principal Investigator
  
  上原至雅
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  National Institute of Infectious Diseases
天然物由来癌転移抑制物質の研究Principal Investigator
- Principal Investigator
  
  小宮山寛機
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kitasato Institute
がん増悪因子とその制御に作用する制がん物質の研究
- Principal Investigator
  
  上原至雅
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  国立予防衛生研究所
癌増悪因子とその制御に作用する制癌物質の研究
- Principal Investigator
  
  石塚雅章
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Microbial Chemistry Research Foundation
細胞増殖制御因子および耐性因子に作用する制癌剤の探索とその応用
- Principal Investigator
  
  石塚雅章
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Microbial Chemistry Research Foundation
細胞増殖制御因子および耐性因子に作用する制癌剤の探索とその応用
- Principal Investigator
  
  石塚雅章
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Microbial Chemistry Research Foundation
細胞増殖制御因子および耐性因子に作用する制癌剤の探索とその応用
- Principal Investigator
  
  石塚雅章
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Microbial Chemistry Research Foundation
細胞膜に作用する抗生物質の探索と構造-作用相関の研究
- Principal Investigator
  
  大岳望
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
細胞膜に作用する抗癌抗生物質の探索と構造活性相関の研究
- Principal Investigator
  
  大岳望
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo

All 2007

All Journal Article

[Journal Article] A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production2007
- Author(s)
  長谷川寛雄, 山田恭暉, 小宮山寛機, 林正彦, 石橋正巳, 砂塚敏明, 菅原和行, 鶴田一人, 増田昌人, 高須信行, 塚崎邦弘, 朝長万左男, 上平憲
- Journal Title
  
  Blood 110(5)
  
  Pages: 1664-74
- Data Source
  KAKENHI-PROJECT-18590510

1. 岡田信子 (70194363)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. 林正彦 (20164965)

# of Collaborated Projects: 5 results

# of Collaborated Products: 1 results
3. 石塚雅章 (80159722)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. 井本正哉 (60213253)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 桑野信彦 (80037431)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 小河原宏 (00097198)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 及川勉 (40120141)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 早川洋一 (20208606)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 上原至雅 (50160213)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 沖俊一 (40264676)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 済木育夫 (80133776)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 深海明子 (60300745)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 大岳望 (30013303)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 三上襄 (40092100)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 浦本昌和 (00124363)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 鶴尾隆 (00012667)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. HASEGAWA Hiroo (00398166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. OHTSUKI Kenzo (60124559)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. AKABOSHI Toru (70159325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. FURUYA Teisuke (70050630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 鈴木日出夫 (50013321)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 岡部實裕 (40113534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 深澤秀輔 (10218878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 野瀬清 (70012747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 内藤幹彦 (00198011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 浅沼史樹 (40129309)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 山田恭暉 (60145232)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. 上平憲 (80108290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
29. 前田満和 (60157146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 瀬戸治男 (10013335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. KANN Toh?Seok

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOMIYAMA Kanki 小宮山 寛機

小宮山 寛機 コミヤマ カンキ

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天然由来抗腫瘍性物質の開拓と病態解析への応用Principal Investigator

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天然より得られた抗腫瘍物質の作用機序解析と実験病態モデルでの評価Principal Investigator

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天然物由来癌転移抑制物質の研究Principal Investigator

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[Journal Article] A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 production2007

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Data Source

KOMIYAMA Kanki 小宮山寛機

小宮山寛機コミヤマカンキ