MIYOSHI Shinichiro 三好新一郎

Researcher Number	00190827
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2021: 岡山大学, 医歯薬学総合研究科, 特命教授 2016 – 2017: 岡山大学, 医歯薬学総合研究科, 教授 2011 – 2016: 岡山大学, 医歯(薬)学総合研究科, 教授 2015: 岡山大学, 大学院医歯薬学総合研究科, 教授 2011 – 2012: 岡山大学, 大学院・医歯薬学総合研究科, 教授 … More 2001 – 2002: 獨協医科大学, 医学部, 教授 1999 – 2001: Osaka University Graduate School of Medicine, Assistant Professor, 医学系研究科, 助教授 1997 – 1998: Osaka University Medical School, Associate Professor, 医学部, 助教授 1994 – 1996: 和歌山県立医科大学, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator Thoracic surgery / Respiratory surgery / Basic Section 55040:Respiratory surgery-related / Thoracic surgery Except Principal Investigator Thoracic surgery / Respiratory surgery / Thoracic surgery
Keywords	Principal Investigator 肺癌 / MHC class II / HLA-DR / MTT assay / 外科 / 癌 / 腫瘍幹細胞マーカー / DCLK1 / 悪性胸膜中皮腫 / 抗PD-1抗体 … More / メトホルミン / rejection / transplantation immunity / organ transplantation / 拒絶反応 / 移植免疫 / 臓器移植 / Interferon-γ / Myasthenia gravis / Thymoma / CIITA / 胸水腫 / インターフェロン・ガンマ / インターフェロンガンマ / MHC-classII / HLA-DR^+ / 重症筋無力症 / 胸腺腫 / optimal potasssium concentration / human pulmonary artery smooth muscle cell / human pulmonary artery endothelial cell / lung preservation solution / lung transplantation / 肺動脈内皮細胞 / 平滑筋細胞 / MTTassay / カリウム濃度 / 人培養肺動脈血管内皮細胞 / 人培養肺動脈血管平滑筋細胞 / 肺保存液 / 肺移植 / PULMONARY FUNCTION TEST / ODOMETER / INCREMENTAL EXERCISE TEST / PREOPERATIVE REHABILITATION / THORACOTOMY / LUNG CANCER / 術後合併症 / 肺機能 / 万歩計 / 段階的運動負荷試験 / 術前リハビリテーション / 開胸手術 / チロシンキナーゼ阻害剤 / 遺伝子変異 / HER2 / マイクロRNA / 原発性肺癌 … More Except Principal Investigator decoy / 肺障害 / Hepatocyte Growth Factor / Gene therapy / HVJ-liposome / NO / 肺移植 / 急性拒絶反応 / Nitric Oxide / ラット肺移植 / 癌幹細胞 / 薬剤耐性 / 悪性胸膜中皮腫 / マイクロRNA / ERBB2 / サイトケラチン19 / HER2 / 外科 / 癌 / 次世代シーケンサー / EGFR / 分子標的治療薬 / 非小細胞肺癌 / PDX / EMT / 次世代シークエンサー / 分子バーコード / 分子標的薬 / 肺癌 / lung injury / HVJ liposome / transfection / NF-kB / acute rejection / nitric oxide / rat lung transplantation / HVJ-liposome法 / NFkB / 肺傷害 / NFKB / 遺伝子導入 / NF-KB / Lung Growth / Lung Transplantation / Chronic Rejection / Gene Therapy / 肺移殖 / 肺線維症 / HGF / 代償性再生 / lung growth, / 肺移植, / HGF, / lung growth / lung transplantation / Chronic rejection / hepatocyte growth facter / Angiogenesis / Apoptosis / Myocardial fibrosis / Dilated cardiomyopathy (DCM) / in vivo genetrausfection / Hepatocyte growth factor (HGF) / 虚血再灌流障害 / 遺伝子治療 / 血管新生 / アポトーシス / 線維化 / 拡張型心筋症 / HVJ-リポソーム法 / in vivo gene transfection / 肝細胞増殖因子(HGF) / BAL cell / Acute Rejection / iNOS / Rat lung transplantation / エンドセリン / ケモカイン / 拒絶反応 / ラット / mRNA / RT-RCR / BAL / Immunosuppressive therapy / Myasthenia gravis / T細胞 / アセチルコリンレセプター / 免疫抑制療法 / 重症筋無力症 / 上皮成長因子受容体チロシンキナーゼ阻害薬 / 上皮間葉移行 / 上皮成長因子受容体チロシンキナーゼ阻害剤 / 原発性肺癌 / 悪性中皮腫 / miR-34b/c / 分子腫瘍学 / 胸部悪性腫瘍 / methylatin / RB pathway / NSCLC / ウサギ肺 / カリウム濃度 / 肺保存 Less

Novel treatment strategy for malignant pleural mesothelioma targeting the tumor stem cell marker DCLK1Principal Investigator
- Principal Investigator
  
  Miyoshi Shinichiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Development of new therapeutic strategy based on gene expression and mutation profiles in EGFR mutant lung cancer
- Principal Investigator
  
  Toyooka Shinichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Novel therapeutic method for HER2 active cancer focusing on HER2 novel binding molecule cytokeratin 19
- Principal Investigator
  
  SOH JUNICHI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Development of new immunotherapy for lung cancer by combined application of diabetes drug metformin and anti-PD-1 antibodyPrincipal Investigator
- Principal Investigator
  
  Miyoshi Shinichiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Identification of novel targets in the treatment of lung cancerPrincipal Investigator
- Principal Investigator
  
  Miyoshi Shinichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Understanding and overcoming drug resistance to EGFR-inhibitors for lung cancer
- Principal Investigator
  
  Toyooka Shinichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
New treatment strategy for malignant pleural mesothelioma focusing on microRNAs related to cancer stem cell makers
- Principal Investigator
  
  SOH JUNICHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Detection of aberrant expression of microRNAs and development of new diagnostics and treatment in lung cancerPrincipal Investigator
- Principal Investigator
  
  MIYOSHI Shinichiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Okayama University
Development of the new therapeutic approach for malignant pleural mesothelioma by the elucidation of aberrant microRNA expression
- Principal Investigator
  
  TOYOOKA Shinichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Okayama University
New method for controlling the rejection which are due to the expression suppression of the MHC class II moleculePrincipal Investigator
- Principal Investigator
  
  MIYOSHI Shinichirou
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Dokkyo University School of Medicine
Gene therapy in lung transplantation. Attenuation of ischemia/reperfusion injury and acute rejection by NF-kB decoy transfection
- Principal Investigator
  
  MINAMI Masato
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Osaka University
Researches on novel techniques of organ-selective gene therapy in thoracic surgery
- Principal Investigator
  
  MATSUDA Hikaru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Thoracic surgery
- Research Institution
  Osaka University
In vivo gene transfer into the lung Application in lung transplantation and therapeutic potential of HGF
- Principal Investigator
  
  TAKEDA Shin-ichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Osaka University
原発性肺癌におけるp16、pRB、cycIinD1の異常と癌増殖能の関連
- Principal Investigator
  
  YOON Hyung-eun (尹享彦)
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Osaka University
Immunosuppressive therapy for myasthenia gravis.
- Principal Investigator
  
  OKUMURA Meinoshin
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Osaka University
Role of Chemokines in Acute Rejection after Rat Lung Transplantation. Interaction with Nitric Oxide and Endothelin.
- Principal Investigator
  
  MINAMI Masato
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Osaka University Graduate School of Medicine
Biological research for elucidation of molecular mechanisms responsible for thymoma-associated myasthenia gravisPrincipal Investigator
- Principal Investigator
  
  MIYOSHI Shinichiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Osaka University
OPTIMUM POTASSIUM CONCENTRATION OF THE PULMONARY PRESERVATION SOLUTION FOR CULTURED PULMONARY ENDOTHELIAL AND SMOOTH MUSCLE CELLSPrincipal Investigator
- Principal Investigator
  
  MIYOSHI Shinichiro
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Osaka University
  Wakayama Medical University
肺保存液における至適カリウム濃度およびそのメカニズムに関する研究
- Principal Investigator
  
  平井一成
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  Wakayama Medical University
HOME REHABILITATION FOR PREOPERATIVE THORACOTOMY PATIENTSPrincipal Investigator
- Principal Investigator
  
  MIYOSHI Shinichiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Thoracic surgery
- Research Institution
  WAKAYAMA MEDICAL COLLEGE

All 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway.2016
- Author(s)
  Ohtsuka T, Sakaguchi M, Yamamoto H, Tomida S, Takata K, Shien K, Hashida S, Miyata-Takata T, Watanabe M, Suzawa K, Soh J, Youyi C, Sato H, Namba K, Torigoe H, Tsukuda K, Yoshino T, Miyoshi S, Toyooka S.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 39557-39557
- DOI
  10.1038/srep39557
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01574, KAKENHI-PROJECT-26293318, KAKENHI-PROJECT-26293352, KAKENHI-PROJECT-15K14382, KAKENHI-PROJECT-16K10681
[Journal Article] Antitumor effect of afatinib, as a human epidermal growth factor receptor 2-targeted therapy, in lung cancers harboring HER2 oncogene alterations2016
- Author(s)
  Ken Suzawa, Shinichi Toyooka, Masakiyo Sakaguchi, Mizuki Morita, Hiromasa Yamamoto, Shuta Tomida, Tomoaki Ohtsuka, Mototsugu Watanabe, Shinsuke Hashida, Yuho Maki, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda and Shinichiro Miyoshi
- Journal Title
  
  Cancer Science
  
  Volume: 107 Issue: 1 Pages: 45-52
- DOI
  10.1111/cas.12845
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293318, KAKENHI-PROJECT-26293352
[Journal Article] Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma.2016
- Author(s)
  Suzawa K, Yamamoto H, Murakami T, Katayama H, Furukawa M, Shien K, Hashida S, Okabe K, Aoe K, Soh J, Asano H, Tsukuda K, Mimura Y, Toyooka S, Miyoshi S
- Journal Title
  
  Oncol Lett
  
  Volume: 1 Issue: 1 Pages: 705-712
- DOI
  10.3892/ol.2015.3955
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462195
[Journal Article] Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib2015
- Author(s)
  Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Yuichiro Miyoshi, Tomoaki Ohtsuka, Ken Suzawa, Mototsugu Watanabe, Yuho Maki, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Journal Title
  
  Cancer Science
  
  Volume: 10 Issue: 10 Pages: 1377-1384
- DOI
  10.1111/cas.12749
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293302
[Journal Article] Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors.2015
- Author(s)
  Hashida S, Yamamoto H, Shien K, Ohtsuka T, Suzawa K, Maki Y, Furukawa M, Soh J, Asano H, Tsukuda K, Miyoshi S, Kanazawa S, Toyooka S
- Journal Title
  
  Oncology Reports
  
  Volume: 33 Issue: 3 Pages: 1499-1504
- DOI
  10.3892/or.2015.3735
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24791462, KAKENHI-PROJECT-25293302
[Journal Article] TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells2015
- Author(s)
  Otani H, Yamamoto H, Takaoka M, Sakaguchi M, Soh J, Jida M, Ueno T, Kubo T, Asano H, Tsukuda K, Kiura K, Hatakeyama S, Kawahara E, Naomoto Y, Miyoshi S, Toyooka S
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 6 Pages: e0129838-e0129838
- DOI
  10.1371/journal.pone.0129838
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14382, KAKENHI-PROJECT-15H04830, KAKENHI-PROJECT-25293302, KAKENHI-PROJECT-26290039
[Journal Article] Preclinical evaluation of microRNA-34b/c deliverly for malignant pleural mesothelioma2014
- Author(s)
  Ueno T, Toyooka S, Fukazawa T, Kubo T, Soh J, Asano H, Muraoka T, Tanaka N, Maki Y, Shien K, Furukawa M, Sakaguchi M, Yamamoto H, Tsukuda K, Miyoshi S
- Journal Title
  
  Acta Med Okayama
  
  Volume: 68(1) Pages: 23-26
- URL
  http://www.ncbi.nlm.nih.gov/pubmed/24553485
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592061
[Journal Article] Preclinical evaluation of microRNA-34b/c delivery for malignant pleural mesothelioma.2014
- Author(s)
  Ueno T, Toyooka S, Fukazawa T, Kubo T, Soh J, Asano H, Muraoka T, Tanaka N, Maki Y, Shien K, Furukawa M, Sakaguchi M, Yamamoto H, Tsukuda K, Miyoshi S.
- Journal Title
  
  Acta Med Okayama
  
  Volume: 68 Pages: 23-26
- NAID
  120005372648
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592061
[Journal Article] Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.2013
- Author(s)
  Shien K, Toyooka S, Yamamoto H, Soh J, Jida M, Thu KL, Hashida S, Maki Y, Ichihara E, Asano H, Tsukuda K, Takigawa N, Kiura K, Gazdar AF, Lam WL, Miyoshi S.
- Journal Title
  
  Cancer Res.
  
  Volume: 73 Issue: 10 Pages: 3051-3061
- DOI
  10.1158/0008-5472.can-12-4136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390221, KAKENHI-PROJECT-23592061
[Journal Article] The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma.2013
- Author(s)
  Muraoka T, Soh J, Toyooka S, Aoe K, Fujimoto N, Hashida S, Maki Y, Tanaka N, Shien K, Furukawa M, Yamamoto H, Asano H, Tsukuda K, Kishimoto T, Otsuki T, Miyoshi S.
- Journal Title
  
  Lung Cancer
  
  Volume: 82 Issue: 3 Pages: 485-490
- DOI
  10.1016/j.lungcan.2013.09.017
- NAID
  120005367626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592061, KAKENHI-PROJECT-23791570
[Journal Article] Downregulation of microRNA-34 induces cell proliferation and invasion of human mesothelial cells2013
- Author(s)
  Tanaka N, Toyooka S, Soh J, Tsukuda K, Shien K, Furukawa M, Muraoka T, Maki Y, Ueno T, Yamamoto H, Asano H, Otsuki T, Miyoshi S
- Journal Title
  
  Oncol Rep
  
  Volume: 29(6) Issue: 6 Pages: 2169-74
- DOI
  10.3892/or.2013.2351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591566, KAKENHI-PROJECT-23592061
[Journal Article] Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells2013
- Author(s)
  Shien K, Toyooka S, Yamamoto H, Soh J, Jida M, Thu KL, Hashida S, Maki Y, Ichihara E, Asano H, Tsukuda K, Takigawa N, Kiura K, Gazdar AF, Lam WL, Miyoshi S
- Journal Title
  
  Cancer Res
  
  Volume: 73(10) Pages: 3051-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592061
[Journal Article] Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer2012
- Author(s)
  Tanaka N, Toyooka S, Soh J, Kubo T, Yamamoto H, Maki Y, Muraoka T, Shien K, Furukawa M, Ueno T, Asano H, Tsukuda K, Aoe K, Miyoshi S
- Journal Title
  
  Lung Cancer
  
  Volume: 76(1) Issue: 1 Pages: 32-8
- DOI
  10.1016/j.lungcan.2011.10.002
- NAID
  120005311982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592061
[Journal Article] 悪性胸膜中皮腫の新しい分子生物学的異常と治療応用の可能性2012
- Author(s)
  久保孝文、豊岡伸一、三好新一郎
- Journal Title
  
  岡山医学会雑誌
  
  Volume: Vol. 124 No. 3 Pages: 203-206
- NAID
  130004903195
- URL
  https://www.jstage.jst.go.jp/article/joma/124/3/124_203/_article/-char/ja/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591566
[Journal Article] MicroRNA miR-34b/c enhances cellular radiosensitivity of malignant pleural mesothelioma cells2012
- Author(s)
  Maki Y, Asano H, Toyooka S, Soh J, Kubo T, Katsui K, Ueno T, Shien K, Muraoka T, Tanaka N, Yamamoto H, Tsukuda K, Kishimoto T, Kanazawa S, Miyoshi S
- Journal Title
  
  Anticancer Res
  
  Volume: 32(11) Pages: 4871-5
- URL
  http://ar.iiarjournals.org/content/32/11/4871.long
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591566
[Journal Article] Epigenetic silencing of microRNA-34b/c plays an important role in the pathogenesis of malignant pleural mesothelioma2011
- Author(s)
  Kubo T, Toyooka S, Tsukuda K, Sakaguchi M, Fukazawa T, Soh J, Asano H, Ueno T, Muraoka T, Yamamoto H, Nasu Y, Kishimoto T, Pass HI, Matsui H, Huh NH, Miyoshi S
- Journal Title
  
  Clin Cancer Res
  
  Volume: 17(15) Issue: 15 Pages: 4965-74
- DOI
  10.1158/1078-0432.ccr-10-3040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591566
[Presentation] Metformin improves immune function of exhausted peripheral CD8+ T cells derived from cancer patients2017
- Author(s)
  Mototsugu Watanabe, Shingo Eikawa, Kazuhiko Shien, Hiromasa Yamamoto, Tadahiko Shien, Junichi Soh, Hiroyoshi Doihara, Shinichi Toyooka, Shinichiro Miyoshi, Heiichiro Udono
- Organizer
  AACR Annual Meeting 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15637
[Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2016
- Author(s)
  Kei Namba, Shuta Tomida, Ken Suzawa, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  IASLC 17TH WORLD CONFERENCE ON LUNG CANCER
- Place of Presentation
  Vienna, Austria
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2016
- Author(s)
  Kei Namba, Shuta Tomida, Kazuhiko Shien, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  第57回日本肺癌学会総会
- Place of Presentation
  福岡市
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] Metformin improves multiple cytokine producing ability of exhausted peripheral CD8+T cells of cancer patients.2016
- Author(s)
  Watanabe M, Eikawa S, Takenori U, Kunisada Y, Toyota S, Miyoshi S, Udono H
- Organizer
  AACR Annual Meeting 2016
- Place of Presentation
  New Orleans, USA
- Year and Date
  2016-04-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15637
[Presentation] Cytokeratin 19 binds to HER2 and activates HER2 and its downstream signaling2016
- Author(s)
  Tomoaki Ohtsuka, Masakiyo Sakaguchi, Shuta Tomida, Hiromasa Yamamoto, Katsuyoshi Takata, Shinsuke Hashida, Mototsugu Watanabe, Ken Suzawa, Yuho Maki, Junichi Soh, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics
- Place of Presentation
  Maui, Hawaii, USA
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293318
[Presentation] Docetaxel-resitant non-small cell lung cancer cells that acquired cross-resistance to EGFR-tyrosine kinase inhibitor2015
- Author(s)
  Haiyang Chen, Ken Suzawa, Shinsuke Hashida, Tomoaki Ohtsuka, Mototsugu Watanabe, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] Identification of a novel binding protein playing a critical role in HER2 activation in lung cancer cells2015
- Author(s)
  Tomoaki Ohtsuka, Masakiyo Sakaguchi, Katsuyoshi Takata, Shinsuke Hashida, Mototsugu Watanabe, Ken Suzawa, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293318
[Presentation] 悪性胸膜中皮腫に対するREIC/Dkk-3遺伝子治療2015
- Author(s)
  山本寛斉、枝園和彦、牧佑歩、宗淳一、大谷真二、三好健太郎、杉本誠一郎、山根正修、大藤剛宏、渡部昌実、那須保友、公文裕巳、三好新一郎、豊岡伸一
- Organizer
  第56回日本肺癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2015-11-26
- Data Source
  KAKENHI-PROJECT-25462195
[Presentation] Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors2015
- Author(s)
  Yuho Maki, Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Tomoaki Ohtsuka, Ken Suzawa, Masashi Furukawa, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Susumu Kanazawa, Shinichi Toyooka
- Organizer
  AACR 106th Annual Meeting
- Place of Presentation
  米国
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] Anti-tumor effect of afatinib, an irreversible EGFR/HER2 dual inhibitor, in lung cancers harboring HER2 oncogene2015
- Author(s)
  Ken Suzawa, Shinichi Toyooka, Masakiyo Sakaguchi, Tomoaki Ohtsuka, Mototsugu Watanabe, Shinsuke Hashida, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293318
[Presentation] Anti-tumor effect of a bis-anilino pyrimidine compound TAE226 on EGFR-mutant non-small cell lung cancer cells with or without T790M mutation2015
- Author(s)
  Hiromasa Yamamoto, Hiroki Otani, Munenori Takaoka, Masakiyo Sakaguchi, Junichi Soh, Masaru Jida, Tsuyoshi Ueno, Takafumi Kubo, Hiroaki Asano, Kazunori Tsukuda, Katsuyuki Kiura, Shinji Hatakeyama, Eiji Kawahara, Yoshio Naomoto, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] TAE226, a bis-anilino pyrimidine compound, shows anti-tumor effect on EGFR-mutant non-small cell lung cancer cells including T790M mutant2015
- Author(s)
  Hiromasa Yamamoto, Hiroki Otani, Munenori Takaoka, Masakiyo Sakaguchi, Junichi Soh, Masaru Jida, Tsuyoshi Ueno, Takafumi Kubo, Hiroaki Asano, Kazunori Tsukuda, Katsuyuki Kiura, Shinji Hatakeyama, Eiji Kawahara, Yoshio Naomoto, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  16th World Conference on Lung Cancer
- Place of Presentation
  米国
- Year and Date
  2015-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] HER2関連肺癌に対するアファチニブの抗腫瘍効果2015
- Author(s)
  諏澤　　憲，豊岡　伸一，大塚　智昭，渡邉　元嗣，橋田　真輔，牧　　佑歩，山本　寛斉，宗　　淳一，岡田　真典，伊賀　徳周，三好健太郎，杉本誠一郎，山根　正修，大藤　剛宏，三好新一郎
- Organizer
  第58回関西胸部外科学会学術集会
- Place of Presentation
  岡山
- Year and Date
  2015-06-12
- Data Source
  KAKENHI-PROJECT-26293318
[Presentation] The molecular characters of acquired resistant non-small cell lung cancer cells to afatinib2014
- Author(s)
  Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda,Shinichiro Miyoshi
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego, California, U.S.A
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] Acquisition of stem cell-like properties during acquired resistance to epidermal growth factor receptor inhibitors2013
- Author(s)
  Shien K, Toyooka S, Yamamoto H, Soh J, Thu KL, Hashida S, Maki Y, Ichihara E, Asano H, Tsukuda K, Takigawa N, Kiura K, Gazdar AF, Lam WL, Miyoshi S
- Organizer
  AACR Annual Meeting 2013
- Place of Presentation
  Washington DC, USA
- Year and Date
  2013-04-09
- Data Source
  KAKENHI-PROJECT-23592061
[Presentation] Down-regulation of microRNA-34 induces cell proliferation and invasion of human mesothelial cells2012
- Author(s)
  Tanaka N, Toyooka S, Soh J, Tsukuda K, Shien K, Furukawa M, Muraoka T, Maki Y, Ueno T, Asano H, Otsuki T, Miyoshi S
- Organizer
  103rd AACR Annual Meeting
- Place of Presentation
  Chicago, USA
- Year and Date
  2012-04-01
- Data Source
  KAKENHI-PROJECT-23592061
[Presentation] Down-regulation of microRNA34 induces cell proliferation and invasion of human mesothelial cells2012
- Author(s)
  Tanaka N, Toyooka S, Soh J, Tsukuda K, Shien K, Furukawa M, Muraoka T, Maki Y, Ueno T, Asano H, Otsuki T, Miyoshi S
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-22591566
[Presentation] 小細胞肺癌におけるmicroRNA-34b/cのメチル化とその役割2011
- Author(s)
  田中則光、豊岡伸一、宗淳一、浅野博昭、佃和憲、三好新一郎
- Organizer
  日本癌治療学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23592061
[Presentation] MicroRNA-34b/c is significantly down-regulated by aberrant promoter methylation and forced expression of miR-34b/c enhances the radiosensitivity in malignant pleural mesothelioma cells.2011
- Author(s)
  Maki Y, Toyooka S, Asano H, Soh J, Tsukuda K, Muraoka T, Aokage K, Tanaka N, Ueno T, Yamane M, Oto T, Miyoshi S
- Organizer
  AACR Annual Meeting 2011
- Place of Presentation
  Orlando, USA
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-22591566
[Presentation] 小細胞肺癌におけるmicroRNA-34b/cのメチル化とその役割2011
- Author(s)
  田中則光、豊岡伸一、宗淳一、浅野博昭、佃和憲、三好新一郎
- Organizer
  日本癌治療学会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-23592061
[Presentation] The impact of adenoviral gene transfer of microRNA-34b/c on malignant pleural mesotheliomas.2011
- Author(s)
  Soh J, Toyooka S, Kubo T, Fukazawa T, Sakaguchi M, Ueno T, Tsukuda K, Asano H, Yamamoto H, Huh, N, Miyoshi S
- Organizer
  AACR Annual Meeting 2011
- Place of Presentation
  Orlando, USA
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-22591566
[Presentation] Epigenetic silencing of microRNA-34b/c plays a pivotal role in the pathogenesis of malignant pleural mesothelioma2010
- Author(s)
  Toyooka S, Kubo T, Tsukuda K, Sakaguchi M, Fukazawa T, Soh J, Asano H, Nasu Y, Kishimoto T, Pass H, Matsui H, Huh NH, Miyoshi S
- Organizer
  The 10th International Conference of the International Mesothelioma Interest Group
- Place of Presentation
  京都
- Year and Date
  2010-09-01
- Data Source
  KAKENHI-PROJECT-22591566
[Presentation] Epigenetic silencing of micro-RNA-34b/c plays a pivotal role in pathogenesis of malignant mesothelioma2010
- Author(s)
  久保孝文、豊岡伸一、佃和憲、阪口政清、深澤拓也、宗淳一、浅野博昭、上野剛、那須康友、松井秀樹、許南浩、三好新一郎
- Organizer
  第69回日本肺癌学会総会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22591566
[Presentation] 正常中皮細胞におけるmicroRNA34の抑制効果 Tiny RNA drives mesothelial cell mad2010
- Author(s)
  田中則光、豊岡伸一、宗淳一、牧佑歩、村岡孝幸、上野剛、浅野博昭、佃和憲、三好新一郎
- Organizer
  日本癌治療学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22591566
[Presentation] Frequent silencing of tumor suppressive miR-34b/c by aberrant methylation in malignant pleural mesothelioma2010
- Author(s)
  Kubo T, Toyooka S, Tsukuda K, Asano H, Sakaguchi M, Soh J, Ueno T, Yamamoto H, Yamane M, Oto T, Nasu Y, Matsui H, Huh NH, Miyoshi S
- Organizer
  AACR Annual Meeting 2010
- Place of Presentation
  Washington, DC, USA
- Year and Date
  2010-04-19
- Data Source
  KAKENHI-PROJECT-22591566
[Presentation] Anti-tumor effect of afatinib, an irreversible EGFR/HER2 dual inhibitor, in lung cancers harboring HER2 oncogene
- Author(s)
  Ken Suzawa, Shinichi Toyooka, Masakiyo Sakaguchi, Tomoaki Ohtsuka, Mototsugu Watanabe, Shinsuke Hashida, Yuho Maki, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi
- Organizer
  AACR Annual Meeting 2015
- Place of Presentation
  Philadelphia, PA, USA
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-26293318
[Presentation] 新規HER2膜貫通部領域遺伝子変異の機能解析
- Author(s)
  諏澤憲、阪口政清、山本寛斉、宗淳一、牧佑歩、橋田真輔、大塚智昭、渡邉元嗣、浅野博昭、佃和憲、三好新一郎、豊岡伸一
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26293318
[Presentation] Down-regulation of microRNA-34 induces cell proliferation and invasion of human mesothelial cells.
- Author(s)
  Tanaka N, Toyooka S, Soh J, Tsukuda K, Shien K, Furukawa M, Muraoka T, Maki Y, Ueno T, Asano H, Otsuki T, Miyoshi S.
- Organizer
  103rd AACR Annual Meeting
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-23592061

1. TOYOOKA Shinichi (30397880)

# of Collaborated Projects: 9 results

# of Collaborated Products: 40 results
2. SOH Junichi (90559890)

# of Collaborated Projects: 9 results

# of Collaborated Products: 38 results
3. OKUMURA Meinoshin (40252647)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. MINAMI Masato (10240847)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
5. YAMAMOTO Hiromasa (40467733)

# of Collaborated Projects: 7 results

# of Collaborated Products: 19 results
6. TAKEDA Shin-ichi (30236468)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
7. TSUKUDA Kazunori (20346430)

# of Collaborated Projects: 6 results

# of Collaborated Products: 33 results
8. YOON Hyung-eun (50283768)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
9. ASANO Hiroaki (70534775)

# of Collaborated Projects: 5 results

# of Collaborated Products: 27 results
10. 阪口政清 (70379840)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
11. BESSHO Toshiya (60254538)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
12. SHIEN Kazuhiko (30708079)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
13. 冨田秀太 (10372111)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
14. 諏澤憲 (90839713)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
15. MATSUDA Fumihiko (50212220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. SUZUMA Takaomi (20226575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MATSUDA Hikaru (00028614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. NISHIMURA Motonobu (90291442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. SAWA Yoshiki (00243220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MORISHITA Ryuichi (40291439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. KANEDA Yasufumi (10177537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. OHTA Mitsunori (30203805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. SUGUTA Kazuhiko (40216312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. IKEDA Yasunori (80202901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 平井一成 (50254537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 片山博志 (90713975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. OHTSUKA Tomoaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
28. 瀧川奈義夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 市原英基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 木浦勝行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIYOSHI Shinichiro 三好 新一郎

Research Projects

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Novel treatment strategy for malignant pleural mesothelioma targeting the tumor stem cell marker DCLK1Principal Investigator

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Development of new immunotherapy for lung cancer by combined application of diabetes drug metformin and anti-PD-1 antibodyPrincipal Investigator

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Identification of novel targets in the treatment of lung cancerPrincipal Investigator

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Detection of aberrant expression of microRNAs and development of new diagnostics and treatment in lung cancerPrincipal Investigator

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New method for controlling the rejection which are due to the expression suppression of the MHC class II moleculePrincipal Investigator

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MIYOSHI Shinichiro 三好新一郎