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NISHIMURA Motonobu  西村 元延

ORCIDConnect your ORCID iD *help
Researcher Number 90291442
External Links
Affiliation (based on the past Project Information) *help 2016 – 2023: 鳥取大学, 医学部, 教授
2008: 鳥取大学, 医学部, 教授
2007: 大阪大学, 医学系研究科, 教授
2006: Tottori University, Faculty of Medicine, Professor, 医学部, 教授
1999 – 2001: Graduate school of medicine, Osaka university, Assistant professor, 医学系研究科, 助手
1997 – 1998: Osaka University Medical School, Assistant Professor, 医学部, 助手
Review Section/Research Field
Principal Investigator
Basic Section 55030:Cardiovascular surgery-related / Thoracic surgery
Except Principal Investigator
Thoracic surgery / Thoracic surgery / Basic Section 55030:Cardiovascular surgery-related / Cardiovascular surgery
Keywords
Principal Investigator
心筋再生治療 / 脂肪幹細胞 / 細胞シート / 心不全 / 細胞シート治療 / 脂肪由来幹細胞 / ADSC / 再生細胞シート / 重症心不全 / 心筋細胞シート … More / 再生治療 / 脂肪細胞由来幹細胞 / 虚血性心筋症 / Plasma discharge / Hybrid artificial lung / Biocompatible material / Cytokine network / Extracorporeal circulation / 開心術 / 吸引脱血 / prostacyclin / 抗炎症性サイトカイン / 血管内皮 / ハイブリット型人工肺 / プラズマ放電 / ハイブリッド人工肺 / 生体適合性材料 / サイトカインネットワーク / 体外循環 / gene therapy / heart failure / cardiac hypretrophy / 血管申請 / 肝細胞増殖因子 / 虚血性心疾患 / 遺伝子導入 / 遺伝子治療 / 心肥大 … More
Except Principal Investigator
遺伝子導入 / HVJ-liposome / 重症心不全 / GENE TRANSFECTION / 細胞移植 / Tissue Engineering / 細胞シート / panel reactive antibody / 心臓移植 / Gene therapy / 遺伝子治療 / アポトーシス / ラット / 遺伝子導入法 / 血管新生 / 肝細胞増殖因子 / HVJ / LVAS / HVJ-liposome法 / ステントグラフト / 大動脈瘤 / HSP70 / bcl-2 / 脳保護 / 虚血耐性 / 心不全 / 心筋梗塞 / 心筋再生 / cell-free / exosome / 脂肪細胞由来幹細胞 / 心筋再生療法 / 細胞外小胞 / 脂肪幹細胞 / 心筋再生医療 / エクソソーム / ADSC / 腹部大動脈瘤 / stentgraft / decoy型核酸医薬 / stent graft / 分子治療製剤 / 血管内治療 / NFkB / 核酸医薬 / Decellularization / Prosthetic heart valve / Tissue Engineering heart valve / 人工弁 / 脱細胞弁 / gene therapy / tissue engineering / myoblast / stem cell / heart failure / cell sheet / 補助人工心臓 / 骨髄単核球細胞 / 筋芽細胞 / bridge to recovery / 細胞工学 / allo-reactive antibody / hyper cytokinemia / humoral rejection / heart transplantation / left ventricular assist system / Panel reactive antibody / 左室補助人口心臓 / リンパ球 / アロ抗体 / 高サイトカイン血症 / 液性拒絶反応 / 左室補助人工心臓 / Hepatocyte growth factor / Adhesion molecule / Circulatory Support / Cellular vector / Combination therapy / cellular cardiomyoplasty / Severe heart failure / Suicide gene therapy / 接着蛋白 / 補助循環 / 細胞ベクター / 複合治療 / ISCHEMIA-REPERFSION INJURY / HVJ-LIPOSOME METHOD / ORGAN PRESERVATION / nFkB DECOY / END-STAGE CARDIAC FAILURE / HEART TRANSPLANATION / 拒絶耐性 / nFkB-cis element decoy / 再灌流障害 / HVJ liposome / 臓器保存 / nFk B decoy / NF-κB decoy / NF-κB / brain protection / circulatory arrest / 全脳虚血 / NF-kB decoy / NF-kB / 循環停止 / Angiogenesis / Apoptosis / Myocardial fibrosis / Dilated cardiomyopathy (DCM) / in vivo genetrausfection / Hepatocyte growth factor (HGF) / 虚血再灌流障害 / 線維化 / 拡張型心筋症 / HVJ-リポソーム法 / in vivo gene transfection / 肝細胞増殖因子(HGF) / BCL-2 / GRAFT CORNARY ATHEROSCRELOSIS / HJV-LIPOSOME METHOD / HEART TRANSPLANTATION / RAT / HAMSTER / 血管内皮細胞 / HVJリポゾーム法 / 異種移植 / 移植後冠動脈硬化症 / Bcl-2 / 移植心冠動脈硬化症 / HVJ リポゾーム法 / 心移植 / ハムスター / MYOCARDIAL PROTECTION / HVJリポソーム法 / β adrenergic receptor / 虚血性心疾患 / 心筋保護 / microcirculation / liver dysfunction / 術後肝障害 / 開心術 / サイトカイン / 高ビリルビン血症 / minimally invasive surgery / gene tranfer / drug delivery system / vascular stent / aortic aneurysm / HVJ・liposome法 / tolerance in ischemia-reperfusion injury / hypothermic circulatory arrest / gene transfection / 脳虚血 / 低体温循環停止 / Gene expression / Heart Failure / Cardiac Hypertrophy / 遺伝子発現 / 心肥大 / midkine / 心筋リモデリング / 虚血性心筋症 / 心筋再生因子 / ZEUS surgical system / 低侵襲手術 / レーザー / 僧帽弁疾患 / f波高 / 心房細動 / Maze手術 Less
  • Research Projects

    (22 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (39 People)
  •  脂肪細胞由来幹細胞exosomeを用いた新規cell-free心筋再生療法の開発

    • Principal Investigator
      吉川 泰司
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      Tottori University
  •  血管新生因子を添加した脂肪細胞由来再生細胞シートを用いた新しい心筋再生療法の開発Principal Investigator

    • Principal Investigator
      西村 元延
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      Tottori University
  •  Experimental study of cardiac regeneration therapy using adipose-derived stem cell sheetsPrincipal Investigator

    • Principal Investigator
      NISHIMURA Motonobu
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      Tottori University
  •  Endovascular treatment with oligonucleotide therapeutics for aortic aneurysm

    • Principal Investigator
      SHIRAYA Suguru
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular surgery
    • Research Institution
      Tottori University
  •  Identification and therapeuticeffect of growth factor inducingmyoblast sheet transplantation in infarcted rat hearts

    • Principal Investigator
      FUKUSHIMA Norihide
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Osaka University
  •  Establishment of Regenerative Therapy for Patients with Left Ventricular Assist Device 〜Aiming to 'Bridge to Recovery〜

    • Principal Investigator
      MATSUMIYA Goro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      OSAKA UNIVERSITY
  •  Minimally-immunogenic Decellularized Porcine Valve Provides In-situ Recellularization in a Stentless Bioprosthetic Valve

    • Principal Investigator
      ICHIKAWA Hajime
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      OSAKA UNIVERSITY
  •  低侵襲性を求めた完全内視鏡下心臓手術法の確立

    • Principal Investigator
      OHTAKE Shigeaki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Osaka University
  •  Development of novel myocardial regeneration therapy for severe heart failure using cellular cardiomyoplasty and gene transfection

    • Principal Investigator
      SAWA Yoshiki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      OSAKA UNIVERSITY
  •  Biological monitoring of immunological modifications in patients supported with left ventricular assist system

    • Principal Investigator
      MATSUMIYA Goro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Osaka University
  •  ESTABLISHMENT OF NEW IMMUNOSUPPRESSIVE STRATEGY USING GENE TRANSFECTION TECHNIQUE

    • Principal Investigator
      FUKUSHIMA Norihide
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      OSAKA UNIVERSITY
  •  Researches on novel techniques of organ-selective gene therapy in thoracic surgery

    • Principal Investigator
      MATSUDA Hikaru
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Thoracic surgery
    • Research Institution
      Osaka University
  •  A new strategy for brain protection during circulatory arrest

    • Principal Investigator
      SAWA Yoshiki, 市川 肇
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Osaka University
  •  Development of gene therapy to myocardium using transvenous gene transfection method.

    • Principal Investigator
      SAWA Yoshiki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Osaka University
  •  Anovel strategy for heart disease using gene therapyPrincipal Investigator

    • Principal Investigator
      NISHIMURA Motonobu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Osaka University
  •  ESTABLISHMENT OF NEW IMMUNOSUPPRESSIVE STRATEGY USING GENE TRANSFECTION TECHNIQUE

    • Principal Investigator
      FUKUSHIMA Norihide
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      OSAKA UNIVERSITY
  •  Development of biocompatible, next-generation cardiopulmonary bypass systemPrincipal Investigator

    • Principal Investigator
      NISHIMURA Motonobu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Osaka University
  •  Novel clinical strategy for thoracic anerysm using intra/extra vascular stenting and molecular biological drug delivery system.

    • Principal Investigator
      HIRATA Nobuaki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Osaka University
  •  Development of the gene therapy against the organ dysfunction in the patients under LVAS support.

    • Principal Investigator
      SAWA Yoshiki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Osaka University
  •  体外循環を用いない心房細動根治術(pumpless Maze)の開発

    • Principal Investigator
      MATSUDA Hikaru
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Thoracic surgery
    • Research Institution
      Osaka University
  •  Mechanism od Cardiac Hypertrophy ; The Efficacy of Gene Therapy in Cardiac Hypertrophy

    • Principal Investigator
      TAKAHASHI Toshiki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Osaka University
  •  Prevention of hypoxic brain damage by in vivo transfection through the carotid artery in cirsulatory arrest

    • Principal Investigator
      FUKUSHIMA Norihide, 今川 弘
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Thoracic surgery
    • Research Institution
      Osaka University

All 2022 2021

All Journal Article

  • [Journal Article] α1-Adrenergic receptor mediates adipose-derived stem cell sheet-induced protection against chronic heart failure after myocardial infarction in rats2022

    • Author(s)
      Horie H, Hisatome I, Kurata Y, Yamamoto Y, Notsu T, Adachi M, Li P, et al
    • Journal Title

      Hypertension research

      Volume: 45 Issue: 2 Pages: 283-291

    • DOI

      10.1038/s41440-021-00802-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08074, KAKENHI-PROJECT-19K08557, KAKENHI-PROJECT-21K08844
  • [Journal Article] Esm1 and Stc1 as Angiogenic Factors Responsible for Protective Actions of Adipose-Derived Stem Cell Sheets on Chronic Heart Failure After Rat Myocardial Infarction2021

    • Author(s)
      Watanabe Mai、Horie Hiromu、Kurata Yasutaka、Inoue Yumiko、Notsu Tomomi、Wakimizu Takayuki、Adachi Maya、Yamamoto Kenshiro、Morikawa Kumi、Kuwabara Masanari、Sakaguchi Takuki、Morisaki Takayuki、Miake Junichiro、Nishimura Motonobu、Tsuneto Motokazu、Shirayoshi Yasuaki、Ito Shin、Kitakaze Masafumi、et al.
    • Journal Title

      Circ J

      Volume: 85 Issue: 5 Pages: 657-666

    • DOI

      10.1253/circj.CJ-20-0877

    • NAID

      130008028975

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2021-04-23
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K08557, KAKENHI-PROJECT-18K08757, KAKENHI-PROJECT-21K08844, KAKENHI-PROJECT-20K20662
  • 1.  SAWA Yoshiki (00243220)
    # of Collaborated Projects: 19 results
    # of Collaborated Products: 0 results
  • 2.  FUKUSHIMA Norihide (30263247)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 3.  MATSUDA Hikaru (00028614)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 4.  OHTAKE Shigeaki (50243209)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 5.  MATSUMIYA Goro (20314312)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 6.  ICHIKAWA Hajime (60303939)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 7.  HIRATA Nobuaki (70283752)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  TAKAHASHI Toshiki (50263257)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  IMAGAWA Hiromu (90273622)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  SAKAKIDA Satoru (90311753)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 11.  KAGISAKI Koji (30335351)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 12.  岸本 祐一郎 (20623911)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 13.  MASAI Takahumi (30273650)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  MIYAGAWA Shigeru (70544237)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  KANEDA Yasufumi (10177537)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  MORISHITA Ryuichi (40291439)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  舩津 俊宏 (80379239)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 18.  中村 嘉伸 (80335538)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 19.  吉川 泰司 (40570594)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 20.  UENO Takayoshi (60437316)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  SAKAGUCHI Taichi (10467574)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  KURATANI Toru (90448035)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  SHIRAKAWA Yukitoshi (20457013)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  SAITO Atsuhiro (20448038)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  SHIRAKURA Ryota (00116047)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  MIYOSHI Shinichiro (00190827)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  TAKANO Hiroshi (70346196)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  MIYAMOTO Yuji (80229898)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  SHIRAYA Suguru (20601933)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  門場 啓司 (00185886)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  青木 元邦 (00346214)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  原田 真吾 (80529420)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  FUKUI Shinya
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  IMANISHI Yukiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  竹谷 哲
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  久米 よう一
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  張 釖嶂
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  久留 一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  李 佩俐
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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