Furukawa Yusuke 古川雄祐

… Alternative Names

FURUKAWA Yusuke 古川雄祐

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Researcher Number	00199431
Other IDs	https://orcid.org/0000-0002-7249-6418
Affiliation (Current)	2025: 帝京科学大学, 医学教育センター, 教授 2025: 自治医科大学, 医学部, 客員教授
Affiliation (based on the past Project Information) *help	2023: 帝京科学大学, 医学教育センター, 教授 2017 – 2022: 自治医科大学, 医学部, 教授 2010 – 2015: 自治医科大学, 医学部, 教授 2006 – 2007: 自治医科大学, 医学部, 教授 2001 – 2003: 自治医科大学, 医学部, 助教授 … More 1997 – 1998: 自治医科大学, 医学部, 講師 1992 – 1995: 自治医科大学, 医学部, 講師 1990 – 1991: 自治医科大学, 医学部, 助手 1988: Jichi Medical School, Associate, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Hematology / Hematology / Basic Section 54010:Hematology and medical oncology-related / Biological Sciences / Biological Sciences / Cell biology Except Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related / Hematology
Keywords	Principal Investigator E2F / 細胞周期 / 癌 / RB / 転写因子 / 多発性骨髄腫 / エピジェネティクス / 移植・再生医療 / 発現制御 / 遺伝子 … More / インターフェロン / 分子標的療法 / cell cycle / p18 / CML / ABL / BCR / STI571 / JAB / ICE / IRF-1 / cdc2 / リン酸化 / ゲノム解析 / 転写制御 / 創薬 / ハイリスク染色体異常 / T-ALL / 血液腫瘍学 / 急性リンパ性白血病 / 中枢神経白血病 / 急性Tリンパ性白血病 / LSD1阻害剤 / Reaenerative medicine / Transcription / Gene / Cancer / combination therapy / molecular target / phosphorylation / INK4c / CDK inhibitor / ARG / ETV6 / P18 / 併用療法 / 分子標的 / Resistant clone / Daudi cell line / Interferon / STAT / 耐性株 / Daudi細胞 / インターロイキン1抑制性サイトカイン / 自己増殖因子 / 白血病の病態生理 / 合成ペプチド / 白血病細胞の増殖分化 / 単球性白血病細胞株 / インターロイキン1 / microRNA / Microvesicle / 間質細胞 / 接着耐性 / Ｔ細胞性白血病 / 前白血病性幹細胞 / ヒストン脱メチル化酵素 / 移植再生医療 / caspase / 自己複製 / メチル化 / 白血病 / Apaf-1 / アポトーシス / 幹細胞 / p130 / 造血幹細胞 / プロモーター / E2F-1 / 分化 / 遺伝子導入 / Splicing mutation / 白血病細胞 / 癌抑制遺伝子 / p53 … More Except Principal Investigator cdc2遺伝子産物 / 網膜芽腫遺伝子産物Rb / 細胞周期 / electroporation / autocrine growth / tumorigenicity / APOBEC3 / 点突然変異 / MGUS / APOBEC3B / 多発性骨髄腫 / NFS-60 / FCC-P2 / malignant phenotype / gene transfection / 無制限増殖能 / インターロイキン3 / エレクトロポレーション / 遺伝子導入 / 癌形質(白血病性形質) / 分化異常 / 白血病幹細胞 / 自律増殖機構 / 増殖因子依存性増殖 / 無限増殖能 / Stromal-epithelial interactions / Apoptosis susceptibility / Cell cycle / Differentiation expression / Apoptosis inhibitory gene bcl-2 / Tenascin-C / Extracellular Matrix (ECM) glycoproteins / Retinoblastoma gene product (Rb) / ECM糖蛋白テネイシン / bc1-2遺伝子 / アポトーシス誘起 / Rbリン酸化抑制 / 細胞外マトリックス糖蛋白分子 / 水溶性細胞増殖因子EGF / アポトーシス抑制遺伝子bcl-2 / 細胞分化の制御 / 間質・上皮間相互作用 / アポトーシス感受性 / 分化形質発現 / アポトーシス抑制遺伝子bc1-2 / テネイシンC / 細胞外マトリックス(ECM)糖蛋白 / Change Chromatin Structure / Cell Growth Factors / Nonepithelial Stroma Cells / Extracellular Matrix / Glycoprotein Tenascin / E2F Binding Site / cdc2 Gene Product / Cell Cycle / (非)上皮系細胞 / 増殖因子 / 非上皮系間質細胞 / 細胞外マトリックス / クロマチン構造変化 / E2F結合部位 / (非)リン酸化型Rb / 細胞外マトリックスECM / 糖蛋白テネイシン / TGF-β / tumor-related gangliosides / hemopoietins / -independent / factor-dependent / Interleukins (IL-1, Il-3) / autonomous growth / エレクトロポレ-ション(Electroporation)法 / 高電圧パルス法 / 細胞融合法 / 癌関連抗原ガングリオシドGD3 / ガングリオシドGD3 / シアロ糖脂質 / 造血因子 / 癌関連抗原シアロ糖脂質(GangliosideGD3) / エレクトロポレ-ション法(電気穿孔法) / オ-トクリン(Autocrine)機構 / 造腫瘍性 / 増殖因子(非)依存性 / インタ-ロイキン(ILー1,ILー3) / 自律増殖能 / 国際情報交流 / ヒストン修飾 / 造血器腫瘍 / 薬剤耐性 / エピジェネティクス / 血液腫瘍学 / 分化誘導療法 / TGFーβ / 生理活性糖脂質 / ヌ-ドマウス / 担癌動物モデル / 白血病細胞 Less

t(11;14)陽性骨髄腫におけるCyclin D1の転写活性化作用の解明と新規治療への応用Principal Investigator
- Principal Investigator
  
  古川雄祐
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Teikyo University of Science & Technology
The development of a novel therapeutic agent targeting MMSET histone methyltransferase in multiple myelomaPrincipal Investigator
- Principal Investigator
  
  Furukawa Yusuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Jichi Medical University
Identification of a driver gene for progression of multiple myeloma and its application to early treatment intervention
- Principal Investigator
  
  Kuroda Yoshiaki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Jichi Medical University
Development of epigenetic therapies for CNS leukemiasPrincipal Investigator
- Principal Investigator
  
  Furukawa Yusuke
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
HDAC/LSD1転写抑制複合体の異常による染色体転座形成機構の解明Principal Investigator
- Principal Investigator
  
  古川雄祐
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Microvesicle-mediated interaction between multiple myeloma cells and bone marrow stromaPrincipal Investigator
- Principal Investigator
  
  Furukawa Yusuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
ヒストン脱アセチル化酵素（ＨＤＡＣ）による血液細胞運命制御の全体像の解明Principal Investigator
- Principal Investigator
  
  古川雄祐
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Identification of a critical epigenetic mechanism via histone modification in drug resistance of blood cancer cells.
- Principal Investigator
  
  KIKUCHI Jiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Identification of myeloma stem cells and its clinical applicationPrincipal Investigator
- Principal Investigator
  
  FURUKAWA Yusuke
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Elucidation of the de of histone deacetylases (HDACs) in leukemogenesis and its impfication in the treatment of leukemiaPrincipal Investigator
- Principal Investigator
  
  FURUKAWA Yusuke
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
E2Fファミリー転写因子による造血幹細胞の自己複製、アポトーシスの制御機構の解明Principal Investigator
- Principal Investigator
  
  古川雄祐
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
Basic Research for the development of a novel strategy for the treatment of chronic myeloid leukemia with STI571Principal Investigator
- Principal Investigator
  
  FURUKAWA Yusuke
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
造血幹細胞の細胞周期停止機構の解明-転写因子E2Fの役割-Principal Investigator
- Principal Investigator
  
  古川雄祐
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Jichi Medical University
The Mechanisms of Interferon Resistance in Interferon-resis-tant Daudi Subline ; A Role of Interferon Regulatory Factors (IRFs)Principal Investigator
- Principal Investigator
  
  FURUKAWA Yusuke
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Jichi Medical School
血液細胞の増殖・分化における転写因子E2Fの役割の解析および臨床応用Principal Investigator
- Principal Investigator
  
  古川雄祐
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jichi Medical University
血液細胞の分化におけるcdc2ファミリー遺伝子の役割の解析Principal Investigator
- Principal Investigator
  
  古川雄祐
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Regulatory Mochanisms For Proliferation, Differentiation, And Apoptosis of Leukemic Cells In Reference To Cell Cycle Phases.
- Principal Investigator
  
  SAITO Masaki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Hokkaido University
  Jichi Medical University
p53欠損白血病細胞株の異常部位の解析とp53導入により誘導される遺伝子の単離Principal Investigator
- Principal Investigator
  
  古川雄祐
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
TGF-βによるRB遺伝子産物の脱リン酸と癌細胞増殖抑制機序の解明Principal Investigator
- Principal Investigator
  
  古川雄祐
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jichi Medical University
Effects of cdc2 gene and EMC tenasc in on regulation of growth and differentiation of hematopoietic cells
- Principal Investigator
  
  SAITO Masaki
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
ヒト白血病細胞担癌動物モデルを用いた癌細胞の増殖・分化機構の解析と臨床応用
- Principal Investigator
  
  OHTA Masatsugu
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jichi Medical University
Studies on Expression-Mechanism (s) of Malignant Phenotypes Using Growth-Factor Gene-Transfer Methods
- Principal Investigator
  
  SAITO Masaki
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
単球性細胞株JOSK-Iの産生するIL-1の生理活性と臨床応用Principal Investigator
- Principal Investigator
  
  古川雄祐
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Jichi Medical University
Autocrine Proliferation and Differentiation-Capacities of Leukemic Cells, and Molecular Analyses of Leukemic Phenotypes
- Principal Investigator
  
  SAITO Masaki
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School

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All Journal Article Presentation Book Patent

[Book] 造血器腫瘍の治療標的としてのDNA 修復機構。血液内科 642012
- Author(s)
  小山大輔、古川雄祐
- Data Source
  KAKENHI-PROJECT-22591047
[Book] Klotho遺伝子の発現調節機構。Annual Review 腎臓2012
- Author(s)
  古川雄祐、東昌広、草野英二
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22591047
[Book] Klotho遺伝子の発現調節機構。腎と透析 722012
- Author(s)
  東昌広、古川雄祐、草野英二
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22591047
[Book] 骨髄腫細胞と間質細胞の相互作用:薬剤耐性とその対策。BIO Clinica272012
- Author(s)
  菊池次郎、古川雄祐
- Data Source
  KAKENHI-PROJECT-22591047
[Book] ヒストン脱アセチル化酵素阻害剤による多発性骨髄腫の治療。医学のあゆみ 2422012
- Author(s)
  菊池次郎、古川雄祐
- Data Source
  KAKENHI-PROJECT-22591047
[Book] ボルテゾミブの新たな作用機序:エピジェネティック制御を介する骨髄腫細胞の制御。, 造血器腫瘍とエピジェネティクス-治療への応用と新たな展開2012
- Author(s)
  菊池次郎、古川雄祐, 木崎昌弘編
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-22591047
[Book] ボルテゾミブの新たな作用機序と他剤との併用の理論的妥当性。血液内科 642012
- Author(s)
  古川雄祐、菊池次郎
- Data Source
  KAKENHI-PROJECT-22591047
[Book] アルキル化剤の作用機序、適応、副作用。血液内科 652012
- Author(s)
  平岡信弥、古川雄祐
- Data Source
  KAKENHI-PROJECT-22591047
[Book] 多発性骨髄腫の薬剤耐性化とボルテゾミブの抗がん剤併用による抗腫瘍効果増強、血液フロンティア222012
- Author(s)
  菊池次郎、古川雄祐
- Data Source
  KAKENHI-PROJECT-22591047
[Book] ヒストン脱アセチル化酵素阻害剤によるリツキシマブ耐性の克服。血液内科622011
- Author(s)
  古川雄祐、清水瑠美、和田妙子、菊池次郎
- Data Source
  KAKENHI-PROJECT-22591047
[Book] 血清蛋白の検査, 小澤敬也監修、図説臨床看護医学(エディターシップ) 5:[3]2011
- Author(s)
  古川雄祐, 小澤敬也監修
- Total Pages
  7
- Data Source
  KAKENHI-PROJECT-22591047
[Book] 新規抗腫瘍薬ベンダムスチンの作用機序と臨床効果。日薬理誌(新規抗腫瘍薬ベンダムスチンの作用機序と臨床効果。日薬理誌(Folia Pharmacol. Jpn) 13822011
- Author(s)
  古川雄祐、平岡信弥、和田妙子、菊池次郎、加納康彦
- Data Source
  KAKENHI-PROJECT-22591047
[Book] 白血球減少症と無顆粒球症, 図説臨床看護医学(エディターシップ) 5:[4.2]2011
- Author(s)
  古川雄祐, 小澤敬也監修
- Total Pages
  1
- Data Source
  KAKENHI-PROJECT-22591047
[Book] 多発性骨髄腫における細胞死の抑制。血液内科622011
- Author(s)
  古川雄祐、菊池次郎
- Data Source
  KAKENHI-PROJECT-22591047
[Book] 好中球機能異常症, 図説臨床看護医学(エディターシップ) 5:[4.2]2011
- Author(s)
  古川雄祐, 小澤敬也監修
- Total Pages
  15
- Data Source
  KAKENHI-PROJECT-22591047
[Book] ボルテゾミブによる未治療多発性骨髄腫の治療戦略。血液フロンティア 212011
- Author(s)
  木崎昌弘、Meletios A.Demopoulos、安部正博、石田禎夫、古川雄祐
- Data Source
  KAKENHI-PROJECT-22591047
[Book] 染色体分析とFISH,図説臨床看護医学(エディターシップ) 5:[3]2011
- Author(s)
  古川雄祐, 小澤敬也監修
- Total Pages
  10
- Data Source
  KAKENHI-PROJECT-22591047
[Book] 骨髄腫幹細胞を標的とする薬剤。最新医学662011
- Author(s)
  古川雄祐、菊池次郎
- Data Source
  KAKENHI-PROJECT-22591047
[Book] 血漿蛋白とその働き。図説臨床看護医学(エディターシップ) 5: [1. 1]2011
- Author(s)
  古川雄祐、小澤敬也監修
- Total Pages
  3
- Data Source
  KAKENHI-PROJECT-22591047
[Book] B白血病/リンパ芽球性リンパ腫。押味和夫編、悪性リンパ腫の基礎と臨床改訂版2011
- Author(s)
  古川雄祐、加納康彦
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-22591047
[Book] 多発性骨髄腫における薬剤耐性機序。Annual Review血液2010
- Author(s)
  古川雄祐、菊池次郎
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22591047
[Book] 骨髄腫幹細胞研究の進展。血液・腫瘍科、612010
- Author(s)
  菊池次郎、古川雄祐
- Data Source
  KAKENHI-PROJECT-22591047
[Book] 血液疾患と細胞周期〜基礎から臨床まで〜(血液フロンティア特集号)2007
- Author(s)
  古川雄祐
- Total Pages
  144
- Publisher
  医薬ジャーナル社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Book] ホジキンリンパ種/三輪血液病学2006
- Author(s)
  加納康彦, 阿久津美百生, 和泉透, 古川雄祐
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] Soluble SLAMF7 Promotes the Growth of Myeloma Cells via Homophilic Interaction with Surface SLAMF7.2020
- Author(s)
  Kikuchi J, Hori M, Iha H, Toyama-Sorimachi N, Hagiwara S, Kuroda Y, Koyama D, Izumi T, Yasui H, Suzuki A, Furukawa Y.
- Journal Title
  
  Leukemia.
  
  Volume: 34 Issue: 1 Pages: 180-195
- DOI
  10.1038/s41375-019-0525-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08847, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-17K09938, KAKENHI-PROJECT-20K08761, KAKENHI-PLANNED-15H05903
[Journal Article] Eradication of central nervous system leukemia of T-cell origin with a brain-permeable LSD1 inhibitor.2019
- Author(s)
  Saito S, Kikuchi J, Koyama D, Sato S, Koyama H, Osada N, Kuroda Y, Akahane K, Inukai T, Umehara T, Furukawa Y.
- Journal Title
  
  Clin Cancer Res
  
  Volume: 25 Issue: 5 Pages: 1601-1611
- DOI
  10.1158/1078-0432.ccr-18-0919
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-17K16193, KAKENHI-PROJECT-17K09938
[Journal Article] Lysine-specific Demethylase 1 Accelerates Oncogenesis in p53 Heterozygous Mice via Transcriptional Repression of the Residual Trp53 Allele.2019
- Author(s)
  Wada, T, Kikuchi, J, Koyama, D, Honda, H, Furukawa, Y.
- Journal Title
  
  Leukemia Res. 2019; 82: 29-32.
  
  Volume: 82 Pages: 29-32
- DOI
  10.1016/j.leukres.2019.05.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08847, KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-17K09938
[Journal Article] Kinetics of cytokine receptor internalization under steady-state conditions affects growth of neighboring blood cells.2019
- Author(s)
  Nagamachi A, Kikuchi J, Kanai A, Furukawa Y, Inaba T.
- Journal Title
  
  Haematologica
  
  Volume: in press Issue: 7 Pages: 1-14
- DOI
  10.3324/haematol.2019.232959
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02838, KAKENHI-PROJECT-17K09938, KAKENHI-PROJECT-20K08761
[Journal Article] Cell adhesion-induced phosphorylation and inactivation of EZH2 confer drug resistance to acute myeloid leukemia cells.2018
- Author(s)
  Kikuchi J, Kuroda Y, Koyama D, and Furukawa Y.
- Journal Title
  
  Int J Hematol
  
  Volume: 107 Issue: 3 Pages: 383-385
- DOI
  10.1007/s12185-017-2376-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-17K16193, KAKENHI-PROJECT-17K09938
[Journal Article] Myeloma Cells Are Activated in Bone Marrow Microenvironment by the　CD180/MD-1 Complex, Which Senses Lipopolysaccharide.2018
- Author(s)
  Kikuchi J, Kuroda Y, Koyama D, Osada N, Izumi T, Yasui H, Kawase T, Ichinohe T, Furukawa Y.
- Journal Title
  
  Cancer Research
  
  Volume: 78 Issue: 7 Pages: 1766-1778
- DOI
  10.1158/0008-5472.can-17-2446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16193, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-17K09938
[Journal Article] Lysine-specific demethylase 1 inhibitors prevent teratoma development from human induced pluripotent stem cells.2018
- Author(s)
  Osada N, Kikuchi J, Umehara T, Sato S, Urabe M, Abe T, Hayashi N, Sugitani M, Hanazono Y, and Furukawa Y.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 5 Pages: 6450-6462
- DOI
  10.18632/oncotarget.24030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-16H05089, KAKENHI-PROJECT-17K09938
[Journal Article] Involvement of innate immunity in the expansion of multiple myeloma cells and therapeutic intervention with lenalidomide2018
- Author(s)
  Furukawa Y, Kuroda Y, Kikuchi J.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 59 Issue: 8 Pages: 1048-1057
- DOI
  10.11406/rinketsu.59.1048
- NAID
  130007472200
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09937, KAKENHI-PROJECT-17K09938
[Journal Article] Overexpression of the Shortest Isoform of Histone Demethylase LSD1 Primes Hematopoietic Stem Cells for Malignant Transformation.2015
- Author(s)
  Wada, T., Koyama, D., Kikuchi, J., Honda, H. and Furukawa, Y.
- Journal Title
  
  Blood
  
  Volume: 125 Pages: 3731-3746
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461434
[Journal Article] Molecular Pathogenesis of Multiple Myeloma.2015
- Author(s)
  Furukawa, Y. and Kikuchi, J.
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 20 Pages: 413-422
- NAID
  40022340491
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461434
[Journal Article] Overexpression of the Shortest Isoform of Histone Demethylase LSD1 Primes Hematopoietic Stem Cells for Malignant Transformation.2015
- Author(s)
  Wada, T., Koyama, D., Kikuchi, J., Honda, H. and Furukawa, Y.
- Journal Title
  
  BLOOD
  
  Volume: 125 Pages: 0000-0000
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25118721
[Journal Article] Overexpression of the Shortest Isoform of Histone Demethylase LSD1 Primes Hematopoietic Stem Cells for Malignant Transformation.2015
- Author(s)
  Wada, T., Koyama, D., Kikuchi, J., Honda, H. and Furukawa, Y.
- Journal Title
  
  BLOOD
  
  Volume: 125 Pages: 0000-0000
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461434
[Journal Article] Phosphorylation-mediated EZH2 Inactivation Promotes Drug Resistance in Multiple Myeloma.2015
- Author(s)
  Kikuchi, J., Koyama, D., Wada, T., Izumi, T., Hofgaard, P.O., Bogen, B. and Furukawa, Y.
- Journal Title
  
  The Journal of Clinical Investigation
  
  Volume: 125 Pages: 4375-4390
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461434
[Journal Article] Suitable drug combination with bortezomib for multiple myeloma under stroma-free conditions and in contact with fibronectin or bone marrow stromal cells.2014
- Author(s)
  Kikuchi J, Koyama D, Mukai YH, and Furukawa Y.
- Journal Title
  
  Int J Hematol
  
  Volume: in press Issue: 6 Pages: 726-736
- DOI
  10.1007/s12185-014-1573-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591405, KAKENHI-PUBLICLY-25118721, KAKENHI-PROJECT-25461434, KAKENHI-PROJECT-26461430
[Journal Article] Purine analog-like properties of bendamustine underlie rapid activation of DNA damage response and synergistic effects with pyrimidine analogues in lymphoid malignancies.2014
- Author(s)
  Hiraoka N, Kikuchi J, Yamauchi T, Koyama D, Wada T, Uesawa M, Akutsu M, Mori S, Nakamura Y, Ueda T, Kano Y, Furukawa Y.
- Journal Title
  
  Plos One
  
  Volume: 13 Issue: 3 Pages: e90675-e90675
- DOI
  10.1371/journal.pone.0090675
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23501307, KAKENHI-PUBLICLY-25118721, KAKENHI-PROJECT-25461434
[Journal Article] Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia.2014
- Author(s)
  Koyama D, Kikuchi J, Hiraoka N, Wada T, Kurosawa H, Chiba S, and Furukawa Y.
- Journal Title
  
  Leukemia
  
  Volume: in press Issue: 6 Pages: 1216-1226
- DOI
  10.1038/leu.2013.366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23591405, KAKENHI-PROJECT-23591549, KAKENHI-PUBLICLY-25118721, KAKENHI-PROJECT-25461434, KAKENHI-PROJECT-26461430
[Journal Article] Arf tumor suppressor disrupts the oncogenic positive feedback loop including c-Myc and DDX5.2014
- Author(s)
  Tago K, Funakoshi-Tago M, Itoh H, Furukawa Y, Kikuchi J, Kato T, Suzuki K, Yanagisawa K
- Journal Title
  
  Oncogene
  
  Volume: 未定 Issue: 3 Pages: 310-318
- DOI
  10.1038/onc.2013.561
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23570166, KAKENHI-PUBLICLY-25118721, KAKENHI-PUBLICLY-25121724, KAKENHI-PROJECT-25293013, KAKENHI-PROJECT-25460073, KAKENHI-PROJECT-25461434, KAKENHI-PROJECT-26440062, KAKENHI-PROJECT-26461430
[Journal Article] Alkylating agents induce histone H3K18 hyperacetylation and potentiate HDAC inhibitor-mediated global histone acetylation and cytotoxicity in mantle cell lymphoma.2013
- Author(s)
  Hiraoka N, Kikuchi J, Koyama D, Wada T, Mori S, Nakamura Y, and Furukawa Y.
- Journal Title
  
  Blood Cancer J
  
  Volume: 3 Issue: 12 Pages: 2169-2169
- DOI
  10.1038/bcj.2013.66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591405
[Journal Article] Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding.2013
- Author(s)
  Kikuchi J, Shibayama N, Yamada S, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, Sugiyama K, Ohki M, Park SY, and Furukawa Y.
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591405
[Journal Article] BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia.2013
- Author(s)
  Kuroda I, Inukai T, Zhang X, Kikuchi J, Furukawa Y, Nemoto A, Akahane K, Hirose K, Honna-Oshiro H, Goi K, Kagami K, Yagita H, Tauchi T, Maeda Y, Sugita K.
- Journal Title
  
  Oncogene
  
  Volume: 32 Pages: 1670-1681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591405
[Journal Article] The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases.2013
- Author(s)
  Kikuchi J, Yamada S, Koyama D, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, and Furukawa Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Issue: 35 Pages: 25593-25602
- DOI
  10.1074/jbc.m113.480574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591405
[Journal Article] BCR-ABL Regulates Death Receptor Expression for TNF-related Apoptosis-inducing Ligand (TRAIL) in Philadelphia Chromosome-positive Leukemia.2013
- Author(s)
  Kuroda, I., Inukai, T., Zhang, X., Kikuchi, J., Furukawa, Y., Nemoto, A., Akahane, K., Hirose, K., Honna-Ooshiro, H., Goi, K., Kagami, K., Yagita, H., Tauchi, T., Maeda, Y. and Sugita, K.
- Journal Title
  
  Oncogene
  
  Volume: 32 Pages: 1670-1681
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] Homopiperazine Derivatives as a Novel Class of Proteasome Inhibitors with a Unique Mode of Proteasome Binding.2013
- Author(s)
  Kikuchi J.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 4 Pages: e60649-e60649
- DOI
  10.1371/journal.pone.0060649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591047, KAKENHI-PROJECT-23591405, KAKENHI-PROJECT-23791089, KAKENHI-PROJECT-25291016, KAKENHI-PUBLICLY-23118524
[Journal Article] Alkylating agents induce histone H3K18 hyperacetylation and potentiate HDAC inhibitor-mediated global histone acetylation and cytotoxicity in mantle cell lymphoma2013
- Author(s)
  Hiraoka N, Kikuchi J, Koyama D, Wada T, Mori S, Nakamura Y, and Furukawa Y
- Journal Title
  
  Blood Cancer J
  
  Volume: 3
- Data Source
  KAKENHI-PROJECT-23591405
[Journal Article] Romidepsin overcomes cell adhesion-mediated drug resistance in multiple myeloma cells.2013
- Author(s)
  Sripayap P, Nagai T, Noborio-Hatano K, Kikuchi J, Furukawa Y, and Ozawa K.
- Journal Title
  
  Acta Hematol
  
  Volume: 132 Pages: 1-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591405
[Journal Article] The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases2013
- Author(s)
  Kikuchi J, Yamada S, Koyama D, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, and Furukawa Y
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Pages: 25593-25602
- Data Source
  KAKENHI-PROJECT-23591405
[Journal Article] Homopiperazine Derivatives as a Novel Class of Proteasome Inhibitors with a Unique Mode of Proteasome Binding2013
- Author(s)
  Kikuchi, J., Shibayama, N., Yamada, S., Wada, T., Nobuyoshi, M., Izumi, T., Akutsu, M., Kano, Y., Sugiyama, K., Ohki, M., Park, S.-Y. and Furukawa, Y.
- Journal Title
  
  PLoS One
  
  Volume: 8
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome- positive leukemia2013
- Author(s)
  Kuroda I, Inukai T, Zhang X, Kikuchi J, Furukawa Y, Nemoto A, Akahane K, Hirose K, Honna-Oshiro H, Goi K, Kagami K, Yagita H, Tauchi T, Maeda Y, Sugita K
- Journal Title
  
  Oncogene
  
  Volume: 32 Pages: 1670-1681
- Data Source
  KAKENHI-PROJECT-23591405
[Journal Article] Romidepsin overcomes cell adhesion- mediated drug resistance in multiple myeloma cells2013
- Author(s)
  Sripayap P, Nagai T, Noborio-Hatano K, Kikuchi J, Furukawa Y, and Ozawa K
- Journal Title
  
  Acta Hematol
  
  Volume: 132 Pages: 1-4
- Data Source
  KAKENHI-PROJECT-23591405
[Journal Article] Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding2013
- Author(s)
  Kikuchi J, Shibayama N, Yamada S, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, Sugiyama K, Ohki M, Park SY, and Furukawa Y
- Journal Title
  
  PLoS One
  
  Volume: 8
- Data Source
  KAKENHI-PROJECT-23591405
[Journal Article] Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR82012
- Author(s)
  Wada T, Kikuchi J, Furukawa Y
- Journal Title
  
  EMBO Reports
  
  Volume: 13 Issue: 2 Pages: 142-149
- DOI
  10.1038/embor.2011.247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591047, KAKENHI-PUBLICLY-23118524, KAKENHI-PROJECT-23791089
[Journal Article] Latexin Regulates the Abundance of Multiple Cellular Proteins in Hematopoietic Stem Cells.2012
- Author(s)
  Mitsunaga, K., Kikuchi, J., Wada, T. and Furukawa, Y.
- Journal Title
  
  J. Cell. Physiol
  
  Volume: 227 Pages: 1138-1147
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] Reduced Histone H3K9 Acetylation of Clock Genes and Abnormal Glucose Metabolism in ob/ob Mice2012
- Author(s)
  Ishikawa-Kobayashi, E., Ushijima, K., Ando, H., Maekawa, T., Takuma, M., Furukawa, Y. and Fujimura, A.
- Journal Title
  
  Chronobiol. Int
  
  Volume: 29 Pages: 982-993
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] Histone Deacetylase 1 Enhances microRNA Processing via Deacetylation of DGCR82012
- Author(s)
  Wada, T., Kikuchi, J. and Furukawa, Y.
- Journal Title
  
  EMBO Rep
  
  Volume: 13 Pages: 142-149
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] Promoter Methylation Confers Kidney-specific Expression of the Klotho Gene.2012
- Author(s)
  Azuma, M., Koyama, D., Kikuchi, J., Yoshizawa, H., Thasinas, D., Shiizaki, K., Kuro-o, M., Furukawa, Y. and Kusano, E.
- Journal Title
  
  FASEB J
  
  Volume: 26 Pages: 4264-4274
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cells2012
- Author(s)
  Mitsunaga K, Kikuchi J, Wada T, Furukawa Y
- Journal Title
  
  Journal of Cellular Physiology
  
  Volume: 227 Issue: 3 Pages: 1138-1147
- DOI
  10.1002/jcp.22834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591047, KAKENHI-PUBLICLY-23118524, KAKENHI-PROJECT-23791089
[Journal Article] Seven-year Follow-up of Patients Receiving Imatinib for the Treatment of Newly Diagnosed Chronic Myelogenous Leukemia by the TARGET System2011
- Author(s)
  Tauchi, T., Kizaki, M., Okamoto, S., Tanaka, H., Tanimoto, M., Inokuchi, K., Murayama, T., Saburi, Y., Hino, M., Tsudo, M., Shimomura, T., Isobe, Y., Oshimi, K., Dan, K., Ohyashiki, K, Ikeda, Y. and the TARGET Investigators (including Furukawa, Y.)
- Journal Title
  
  Leuk. Res
  
  Volume: 35 Pages: 585-590
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] Inactivation of the Retinoblastoma Protein by Mutant B-Raf in Malignant Melanoma2010
- Author(s)
  Kobayashi, Y., Kobayashi, T., Kikuchi, J., Futaki, K., Wada, T., Kusano, E., Murata, S., Ohtsuki, M. and Furukawa, Y.
- Journal Title
  
  Nature Precedings
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] Up-regulation of Survivin by the E2A-HLF Chimera Is Indispensable for the Survival of t(17;19)-positive Leukemia Cells2010
- Author(s)
  Okuya, M., Kurosawa, H., Kikuchi, J., Furukawa, Y., Matsui, H., Aki, D., Matsunaga, T., Inukai, T., Goto, H., Altura, R.A., Sugita, K., Arisaka, O., Look, A.T. and Inaba, T.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Pages: 1850-1860
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] Vinculin Is Indispensable for Repopulation by Hematopoietic Stem Cells, Independent of Integrin Function.2010
- Author(s)
  Ohmori, T., Kashiwakura, Y., Ishiwata, A., Madoiwa, S., Mimuro, J., Furukawa, Y. and Sakata, Y.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Pages: 31763-31773
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] HDAC Inhibitors Augment Cytotoxic Activity of Rituximab by Upregulating CD20 Expression on Lymphoma Cells2010
- Author(s)
  Shimizu, R., Kikuchi, J., Wada, T., Ozawa, K., Kano, Y. and Furukawa, Y.
- Journal Title
  
  Leukemia
  
  Volume: 24 Pages: 1760-1768
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] Aberrant Induction of LMO2 by the E2A-HLF Chimeric Transcription Factor and Its Implication in Leukemogenesis of B-Precursor ALL with t(17;19)2010
- Author(s)
  Hirose, K., Inukai,T., Kikuchi, J., Furukawa, Y., Ikawa, T., Kawamoto, H., Oram, S.H., Gottgens, B., Kiyokawa, N., Miyagawa, Y., Okita, H., Akahane, K., Zhang, X., Kuroda, I., Honna, H., Kagami, K., Goi, K., Kurosawa, H., Look, A.T., Matsui, H., Inaba, T.
- Journal Title
  
  Blood
  
  Volume: 116 Pages: 962-970
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] MSK1 Activation in Acute Myeloid Leukemia Cells with FLT3 Mutations2010
- Author(s)
  Odgerel, T., Kikuchi, J., Wada, T., Shimizu, R., Kano, Y. and Furukawa, Y.
- Journal Title
  
  Leukemia
  
  Volume: 24 Pages: 1087-1090
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] Histone Deacetylases Are Critical Targets of Bortezomib-induced Cytotoxicity in Multiple Myeloma2010
- Author(s)
  Kikuchi, J., Wada, T., Shimizu, R., Izumi, T., Akutsu, M., Mitsunaga, K., Noborio-Hatano, K., Nobuyoshi, M., Ozawa, K., Kano, Y. and Furukawa, Y.
- Journal Title
  
  Blood
  
  Volume: 116 Pages: 406-417
- Data Source
  KAKENHI-PROJECT-22591047
[Journal Article] CD43, but not P-selectin Glycoprotein Ligand-1, Functions as an E-Selectin Counter-Receptor in Human Pre-B-Cell Leukemia NALL-12008
- Author(s)
  Nonomura, C., Kikuchi, J., Kiyokawa, N., Ozaki, H., Mitsunaga, K., Ando, H., Kanamori, A., Kannagi, .R., Fujimoto, J., Muroi, K., Furukawa., Y., Nakamura, M
- Journal Title
  
  Cancer Res 68
  
  Pages: 790-799
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] Transcriptional Modulation Using HDACi Depsipeptide Promotes Immune Cell-Mediated Tumor Destruction of Murine B16 Melanoma2008
- Author(s)
  Murakami, T., Sato, A., Chun, N. A. L., Hara, M., Naito, Y., Kobayashi, Y., Kano, Y., Ohtsuki, M., Furukawa., Y., Kobayashi, E
- Journal Title
  
  J. Invest. Dermatol 128
  
  Pages: 1506-1516
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] Activation of Focal Adhesion Kinase in Detached Human Epidermal Cancer Cells and Their Long-term Survival Might be Associated with Cell Surface Expression of Laminin-52008
- Author(s)
  Katayama, H., Yamane, Y., Furukawa, Y., Kitagawa, S., Nakamura, Y., Yoshino, K
- Journal Title
  
  Acta Derm. Venereol 88
  
  Pages: 100-107
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] Cholesterol Reduction and Atherosclerosis Inhibition by Bezafibrate in Low-Density Lipoprotein Receptor Knockout Mice2008
- Author(s)
  Inaba, T., Yagyu, H., Itabashi, N., Tazoe, F., Fujita, N., Nagashima, S., Okada, K., Okazaki, M., Furukawa., Y., Ishibashi, S
- Journal Title
  
  Hypertens. Res 31
  
  Pages: 1001-1007
- NAID
  10021935912
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] The FLT3 Inhibitor PKC412 Exerts Differential Cell Cycle Effects on Leukemic Cells Depending on the Presence of FLT3 Mutations2008
- Author(s)
  Odgerel, T., Kikuchi, J., Wada, T., Shimizu, R., Futaki, K., Kano, Y., Furukawa., Y
- Journal Title
  
  Oncogene 27
  
  Pages: 3102-3110
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] Divergent Cytotoxic Effects of PKC412 in Combination with Conventional Antileukemic Agents in FLT3 Mutation-positive versus Negative Leukemia Cell Lines.2007
- Author(s)
  Furukawa, Y., et. al.
- Journal Title
  
  Leukemia 21
  
  Pages: 1005-1014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] Cytotoxic Effects of Histone Deacetylase Inhibitor FK228(Depsipeptide, Formally Named FR901228) in Combination with Conventional Anti-leukemia/lymphoma Agents against Human Leukemia/lymphoma Cell Lines2007
- Author(s)
  Kano, Y., Akutsu, M., Tsunoda, S., Izumi, T., Kobayashi, H., Mano, H., Furukawa. Y
- Journal Title
  
  Invest. New Drugs 25
  
  Pages: 31-40
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] B-cell Lymphoma Showing Typical Features of Angioimmunoblastic T-cell Lymphoma2007
- Author(s)
  Mori, M., Furukawa., Y., Takatoku, M., Nagai, T., Muroi, K., Ozawa, K
- Journal Title
  
  JMU Journal 30
  
  Pages: 89-95
- NAID
  120006713218
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] Divergent Cytotoxic Effects of PKC412 in Combination with Conventional Antileukemic Agents in FLT3 Mutation-positive versus Negative Leukemia Cell Lines2007
- Author(s)
  Furukawa, Y., et. al.
- Journal Title
  
  Leukemia 21
  
  Pages: 1005-1014
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] E2F-6 Suppresses Growth-associated Apoptosis of Human Hematopoietic Progenitor Cells by Counteracting Proapoptotic Activity of E2F-12007
- Author(s)
  Kikuchi, J., Shimizu, R., Wada, T., Ando, H., Nakamura, M., Ozawa, K., Furukawa., Y
- Journal Title
  
  Stem Cells 25
  
  Pages: 2439-2447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] Rad9 Modulates the p21^<WAF1> Pathway by Direct Association with p532007
- Author(s)
  Ishikawa, K., Ishii, H., Murakumo, Y., Mimori, K., Kobayashi, M., Yamamoto, K.-I., Mon, M., Nishino, H., Furukawa., Y., Ichimura, K
- Journal Title
  
  BMC Mol. Biol 8
  
  Pages: 37-46
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] Divergent Cytotoxic Effects of PKC412 in Combination with Conventional Antileukemic Agents in FLT3 Mutation-positive versus Negative Leukemia Cell Lines2007
- Author(s)
  Furukawa, Y., Vu, H. A., Akutsu, M., Odgerel, T., Izumi, T., Tsunoda, S., Matsuo, Y., Kirito, K., Sato, Y., Mano, H., Kano, Y
- Journal Title
  
  Leukemia 21
  
  Pages: 1005-1014
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] Divergent Cytotoxic Effects of PKC412 in Combination with Conbentional Antileukemic Agents in FLT3 Mutation-positive versus Negative Leukemia Cell Lines.2007
- Author(s)
  Furukawa, Y. et al.
- Journal Title
  
  Leukemia March
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] Histone Deacetylase Inhibitor FK228 Suppresses the Ras-MAP kinase Signaling Pathway by Up-regulating Rap1 and Induces Apoptosis in Malignant Melanoma2006
- Author(s)
  Kobayashi, Y., Ohtsuki, M., Murakami, T., Kobayashi, T., Sutheesophon, K., Kitayama, H., Kano, Y., Kusano, E., Nakagawa, H., Furukawa., Y
- Journal Title
  
  Oncogene 25
  
  Pages: 512-524
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] Schedule-dependent Interactions between Pemetrexed and Cisplatin in Human Carcinoma Cell Lines in vitro2006
- Author(s)
  Kano, Y., Akutsu, M., Tsunoda, S., Izumi, T., Kobayashi, H., Inoue, K., Mori, K., Fujii, H., Mano, H., Odgerel, T., Furukawa, Y
- Journal Title
  
  Oncol. Res 16
  
  Pages: 85-95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] Histone Deacetylase Inhibitor Depsipeptide(FK228) Induces Apoptosis in Leukemic Cells by Facilitating Mitochondrial Translocation of Bax, which Is Enhanced by Proteasome Inhibitor Bortezomib2006
- Author(s)
  Sutheesophon, K., Kobayashi, Y., Takatoku, M., Ozawa, K., Kano, Y., Ishii, H., Furukawa, Y
- Journal Title
  
  Acta Haematol 115
  
  Pages: 78-90
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Journal Article] The Novel Orally Active Proteasome Inhibitor K-7174 Exerts Anti-myeloma Activity in vitro and in vivo by Down-regulating the Expression of Class I Histone Deacetylases.
- Author(s)
  Kikuchi, J., Yamada, S., Koyama, D., Wada, T., Nobuyoshi, M., Izumi, T., Akutsu, M., Kano, Y. and Furukawa, Y.
- Journal Title
  
  J. Biol. Chem
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22591047
[Patent] 腎疾患の予防および治療剤2007
- Inventor(s)
  古川雄祐
- Industrial Property Rights Holder
  古川雄祐
- Filing Date
  2007-04-06
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Patent] 腎疾患の予防および治療剤2007
- Inventor(s)
  古川雄祐
- Industrial Property Rights Holder
  古川雄祐
- Filing Date
  2007-04-06
- Data Source
  KAKENHI-PROJECT-18591083
[Patent] ホモピペラジン化合物を主成分とするプロテアソーム阻害剤
- Inventor(s)
  菊池次郎・古川雄祐
- Industrial Property Rights Holder
  菊池次郎・古川雄祐
- Industrial Property Number
  2011-013923
- Data Source
  KAKENHI-PROJECT-22591047
[Presentation] Bortezomib overcomes the cell adhesion mediated drug resistance by down-regulating HDAC expression in multiple myeloma2013
- Author(s)
  Furukawa Y, Kikuchi J
- Organizer
  14^<th> International Myeloma Workshop
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2013-04-03
- Data Source
  KAKENHI-PROJECT-23591405
[Presentation] Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding2013
- Author(s)
  Kikuchi J, Shibayama N, Yamada S, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, Sugiyama K, Ohki M, Park SY, and Furukawa Y
- Organizer
  14^<th> International Myeloma Workshop
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2013-04-03
- Data Source
  KAKENHI-PROJECT-23591405
[Presentation] Bortezomib Overcomes the Cell Adhesion-mediated Drug Resistance by Down-regulating HDAC Expression in Multiple Myeloma.2013
- Author(s)
  Furukawa, Y. and Kikuchi, J.
- Organizer
  The 14th Intenational Myeloma Workshop
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2013-04-04
- Data Source
  KAKENHI-PROJECT-22591047
[Presentation] Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding2013
- Author(s)
  Kikuchi J, Shibayama N, Yamada S, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, Sugiyama K, Ohki M, Park SY, and Furukawa Y.
- Organizer
  第７５回日本血液学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23591405
[Presentation] Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding2013
- Author(s)
  Kikuchi J, Shibayama N, Yamada S, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, Sugiyama K, Ohki M, Park SY, and Furukawa Y
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2013-10-12
- Data Source
  KAKENHI-PROJECT-23591405
[Presentation] Homopiperazine derivatives as a novel class of proteasome inhibitors with a unique mode of proteasome binding2013
- Author(s)
  Kikuchi J, Shibayama N, Yamada S, Wada T, Nobuyoshi M, Izumi T, Akutsu M, Kano Y, Sugiyama K, Ohki M, Park SY, and Furukawa Y.
- Organizer
  14th International Myeloma Workshop
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591405
[Presentation] Bortezomib overcomes the cell adhesion-mediated drug resistance by down-regulating HDAC expression in multiple myeloma2013
- Author(s)
  Furukawa Y, and Kikuchi J
- Organizer
  14th International Myeloma Workshop
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591405
[Presentation] How to overcome the cell adhesion-mediated drug resistance in multiple myeloma.2012
- Author(s)
  古川雄祐
- Organizer
  第74回日本血液学会学術総会
- Place of Presentation
  京都
- Year and Date
  2012-10-21
- Invited
- Data Source
  KAKENHI-PUBLICLY-23118524
[Presentation] How to overcome the cell adhesion-mediated drug resistance in multiple myeloma2012
- Author(s)
  古川雄祐
- Organizer
  第74回日本血液学会学術総会、Symposium 6 "Multiple Myeloma: Topics in Basic Science Applicable to the Development of Novel Therapies"
- Place of Presentation
  京都
- Year and Date
  2012-10-21
- Data Source
  KAKENHI-PROJECT-22591047
[Presentation] Multiple Myeloma Cells Acquire Anti-cancer Drug Resistnce via Interaction with Bone Marrow Microenvironment2012
- Author(s)
  Furukawa, Y.
- Organizer
  The 9th Nikko Intenational Symposium
- Place of Presentation
  Shimotuke, Tochigi, Japan
- Year and Date
  2012-10-12
- Data Source
  KAKENHI-PROJECT-22591047
[Presentation] Multiple myeloma : Introduction of novel drugs with unique mechanisms of action to overcome drug resistance2011
- Author(s)
  古川雄祐
- Organizer
  第9回日本臨床腫瘍学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-22591047
[Presentation] Latexin regulates the abundance of multiple cellular proteins in hematopoietic stem cells2011
- Author(s)
  光永佳奈枝、菊池次郎、和田妙子、古川雄祐
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-22591047
[Presentation] Multiple myeloma: Introduction of novel drugs with unique mechanisms of action to overcome drug resistance2011
- Author(s)
  古川雄祐
- Organizer
  第9回日本臨床腫瘍学会学術総会、日本臨床腫瘍学会/日本血液学会合同シンポジウム"分子標的治療薬導入から10年を迎えて"
- Place of Presentation
  横浜
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PROJECT-22591047
[Presentation] Low HDAC expression contributes to insufficient maturation of microRNAs in hematopoietic stem cells2011
- Author(s)
  和田妙子、菊池次郎、古川雄祐
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-22591047
[Presentation] Latexin Regulates the Abundance of Multiple Cellular Proteins in Hematopoietic Stem Cells.2011
- Author(s)
  Mitsunaga, K., Kikuchi, J., Wada, T. and Furukawa, Y.
- Organizer
  The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
- Place of Presentation
  Hongo, Tokyo
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22591047
[Presentation] Latexin Regulates the Abundance of Multiple Cellular Proteins in Hematopoietic Stem Cells.2011
- Author(s)
  Mitsunaga, K., Kikuchi, J., Wada, T. and Furukawa, Y.
- Organizer
  The 9th Stem Cell Research Symposium
- Place of Presentation
  Roppongi、Tokyo, Japan
- Year and Date
  2011-05-14
- Data Source
  KAKENHI-PROJECT-22591047
[Presentation] Multiple myeloma : Introduction of novel drugs with unique mechanisms of action to overcome drug resistance2011
- Author(s)
  古川雄祐
- Organizer
  第9回日本臨床腫瘍学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2011-07-21
- Data Source
  KAKENHI-PUBLICLY-23118524
[Presentation] ボルテゾミブによる接着耐性の解除と骨髄腫治療戦略への組み込み2010
- Author(s)
  古川雄祐
- Organizer
  厚生労働省がん研究助成金木崎班班会議特別講演
- Place of Presentation
  東京
- Year and Date
  2010-01-23
- Data Source
  KAKENHI-PROJECT-22591047
[Presentation] ボルテゾミブの抗骨髄腫作用はヒストン脱アセチル化酵素の発現抑制を介する2010
- Author(s)
  菊池次郎、和田妙子、清水瑠美、和泉透、光永佳奈枝、畑野かおる、信吉正治、小澤敬也、加納康彦、古川雄祐
- Organizer
  第35回日本骨髄腫研究会総会
- Place of Presentation
  富山
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-22591047
[Presentation] Histone Deacetylase 1 Acts as a Class ll Transtorming Gene in Acute Myeloblastic Leukemia2007
- Author(s)
  Furukawa, Y.
- Organizer
  The 4th Nikko Intenational Symposium
- Place of Presentation
  栃木県下野市
- Year and Date
  2007-09-29
- Data Source
  KAKENHI-PROJECT-18591083
[Presentation] Histone Deacetylase 1 Acts as a Class II Transforming Gene in Acute Myeloblastic Leukemia2007
- Author(s)
  Furukawa. Y
- Organizer
  The 4th Nikko Intenational Symposium
- Place of Presentation
  Shimotuke, Tochigi, Japan
- Year and Date
  2007-09-29
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Presentation] Histone Deacetylase 1 Acts as a Class II Transforming Gene in AcuteMyeloblastic Leukemia2007
- Author(s)
  Furukawa, Y.
- Organizer
  The 4th Nikko Intenational Symposium
- Place of Presentation
  栃木県下野市
- Year and Date
  2007-09-29
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591083
[Presentation] How to overcome the cell adhesion-mediated drug resistance in multiple myeloma.
- Author(s)
  古川雄祐
- Organizer
  第74回日本血液学会学術総会
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-22591047

1. OHTA Masatsugu (90160514)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. NAKAMURA Mitsuru (20198237)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. SAITO Masaki (60012762)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. KITAGAWA Sei-ichi (50133278)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. KIKUCHI Jiro (60371035)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
6. SAKAI Takao (10235111)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. WADA Taeko (30382956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. MOTOYOSHI Kazuo (80137702)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Kuroda Yoshiaki (00625840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 須田年生 (60118453)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 野尻久雄 (70180742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 長田直希 (60840858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. YAMAUCHI Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. TAGO Kenji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 小山大輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
16. 金井昭教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 長町安希子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 稲葉俊哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Furukawa Yusuke 古川 雄祐

FURUKAWA Yusuke 古川 雄祐

Research Projects

Research Products

Co-Researchers

t(11;14)陽性骨髄腫におけるCyclin D1の転写活性化作用の解明と新規治療への応用Principal Investigator

Principal Investigator

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The development of a novel therapeutic agent targeting MMSET histone methyltransferase in multiple myelomaPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Identification of a driver gene for progression of multiple myeloma and its application to early treatment intervention

Principal Investigator

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Review Section

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Development of epigenetic therapies for CNS leukemiasPrincipal Investigator

Principal Investigator

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HDAC/LSD1転写抑制複合体の異常による染色体転座形成機構の解明Principal Investigator

Principal Investigator

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Review Section

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Microvesicle-mediated interaction between multiple myeloma cells and bone marrow stromaPrincipal Investigator

Principal Investigator

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ヒストン脱アセチル化酵素（ＨＤＡＣ）による血液細胞運命制御の全体像の解明Principal Investigator

Principal Investigator

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Research Institution

Identification of a critical epigenetic mechanism via histone modification in drug resistance of blood cancer cells.

Principal Investigator

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Identification of myeloma stem cells and its clinical applicationPrincipal Investigator

Principal Investigator

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Elucidation of the de of histone deacetylases (HDACs) in leukemogenesis and its impfication in the treatment of leukemiaPrincipal Investigator

Principal Investigator

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Research Institution

E2Fファミリー転写因子による造血幹細胞の自己複製、アポトーシスの制御機構の解明Principal Investigator

Principal Investigator

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Research Institution

Basic Research for the development of a novel strategy for the treatment of chronic myeloid leukemia with STI571Principal Investigator

Principal Investigator

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Research Institution

造血幹細胞の細胞周期停止機構の解明-転写因子E2Fの役割-Principal Investigator

Principal Investigator

Project Period (FY)

Furukawa Yusuke 古川雄祐

FURUKAWA Yusuke 古川雄祐