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SAITO Masaki  齋藤 政樹

ORCIDConnect your ORCID iD *help
… Alternative Names

斉藤 政樹  サイトウ マサキ

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Researcher Number 60012762
External Links
Affiliation (based on the past Project Information) *help 2002 – 2006: 明治薬科大学, 薬学部, 教授
2002 – 2003: 明治薬科大学, 薬効学教室, 教授
2001: Meiji Pharmaceutical University, Profeesor, 教授
1998 – 2001: 国立がんセンター研究所, ウイルス部, 部長
2000: 国立がんセンター研究所, ウィルス部, 部長 … More
1999 – 2000: 国立がんセンター研究所, 部長
1998 – 2000: 国立がんセンター, 研究所・ウイルス部, 部長
1999: Nat'l Cancer Ctr, Virol. Glyocobiol., Chief, ウイルス部, 部長
1999: 国立がんセンター研究所, ウィルス部, 部長(研究職)
1994 – 1998: 北海道大学, 医学部, 教授
1986 – 1994: 自治医科大学, 医学部, 教授
1993: 自治医大, 医学部, 教授
1992: 自治医科大学, 医学部教授
1989: 自治医科大学, 医学部(病), 教授
1989: 自治医科大学, 医学部, 助教授
1986: Jichi Medical School ・ Professor, 医学部, 教授
1986: 自治医科大学, 血液研究所, 教授 Less
Review Section/Research Field
Principal Investigator
Hematology / 広領域 / Hematology / Biological Sciences
Except Principal Investigator
Hematology / Biological Sciences / Religious studies / General medical chemistry / 物質生物化学 / Pathological medical chemistry
Keywords
Principal Investigator
シアル酸転移酵素 / GM3合成酵素欠損マウス / ガングリオシドGM3合成酵素 / II型膜蛋白質 / シアル酸転移酵素-1 / ガングリオシドGD3合成酵素 / ガングリオシド / ガングリオシドGM3 / 細胞周期 / 合成シアロ糖化合物 … More / NEPH2 / シアリルモチーフ / cDNAクローニング / 遺伝子ノックアウト細胞 / N結合型糖鎖 / インターロイキン3 / 糖転移酵素遺伝子 / 糖転移酵素 / ヒト骨髄性白血病細胞 / cDNA Cloning / ゲノム構造 / 5'-RACE法 / シアロコレステロール / 細胞外マトリックス糖蛋白 / シアリルモティーフ / Stromal-epithelial interactions / Extracellular Matrix (ECM) glycoproteins / 間質・上皮間相互作用 / テネイシンC / 細胞外マトリックス / cdc2遺伝子産物 / 網膜芽腫遺伝子産物Rb / electroporation / autocrine growth / tumorigenicity / シアロ糖脂質 / 造血因子 / 分化誘導 / 膀胱がん遺伝子治療 / 複合糖鎖分子(スフィンゴ糖脂質) / ミクロドメイン / 抗GM3合成酵素抗体 / 細胞増殖・分化制御 / ガングリオシド(GM3) / 特異的アミノ酸置換 / シリアルモチーフ / 5`-RACE法 / 糖鎖機能 / 糖鎖遺伝子 / 複合糖質 / PI代謝回転阻害剤 / NFS-60 / FCC-P2 / malignant phenotype / gene transfection / 無制限増殖能 / エレクトロポレーション / 遺伝子導入 / 癌形質(白血病性形質) / 分化異常 / 白血病幹細胞 / 自律増殖機構 / 増殖因子依存性増殖 / 無限増殖能 / HL-60 / differentiation-induction / alpha-sialoglyceride / alpha-sialocholesterol / gangliosides / glycosphingolipids / シアル酸 / グリコシド結合 / HL-60細胞株 / 分化誘導活性 / レチノイン酸耐性HLー60変異株 / シアログリセリド / 薬剤耐性変異株 / 増殖制御 / 3分化誘導 / 骨髄性白血病 / Interleukin-3(IL-3) / Hemopoietic Growth factors / Cellular oncogene c-myb rearrangement / Abelson murine leukemia virus(A-MuLV) / Plasmid gAE1A / Exogenous gene introduction / Pricking method / NFS-60細胞株 / 細胞性腫瘍遺伝子c-myb / Abelson白血病ウイルス / プラスミドgAE1A / 外来性遺伝子導 / プリッキング法 / Membranous Glycoprotein mKirre / Bone Marrow Stromal Cells / Bladder Cancer Therapy by GM3 Synthase / Anti-GM3 Synthase Antibody / GM3 Synthase-Genomic Structure / Growth-Differentiation-Apoptosis Control / Ganglioside GM3 Synthase-deficient Mice / Gangalioside (GM3) / 造血幹細胞維持性膜蛋白因子 / GM3合成シアル酸転移酵素 / インスリン感受性 / GM3合成素欠損マウス / 造血細胞増殖・分化制御 / GM3合成シアル酸転位酵素 / シスエレメント / 造血幹細胞維持性膜蛋白因子mKirre / 骨髄間質(ストローマ)細胞 / 膀胱がん-GM3合成酵素遺伝子治療 / GM3合成酵素-ゲノム構造 / 細胞増殖・分化・細胞死制御 / Cis Element / Three Dimesional Structure / Promoter Region / Gene Kockout / Genomic Structure / Ganglioside GM3 Synthase / Sialoglycosphingolipids / 転写調節 / 遺伝子改変 / プロモーター活性 / Sp1結合部位 / TATA・CAAT配列 / ルシフェラーゼ活性 / シス因子 / 酵素蛋白立体構造 / プロモーター領域 / 遺伝子ノックアウト / シアロスフィンゴ糖脂質 / Extracellular Matrix Glycoprotein / Tenascin / Sialocholesterol / Genomic Structure Analysis / Ganglioside GM3 synthase / Synthetic Sialoglycolipids / Gangliosides / 分化誘導・増殖抑制 / ヒト骨髄性白血病 / 光学異性体β-アノマー / シアロジグリセリド / ガングリオシド類縁体 / 白血病分化誘導 / ガングリオシドGM3糖鎖ポリマー / ヒトLARGE遺伝子 / アミノCTH合成酵素 / シアル酸転移酵素遺伝子 / テネイシン / ゲノム構造解析 / 脂質性シアロ糖化合物 / Programd cell death (Apoptosis) / Integrin VLA-5 / Granulocytic differentiation / Monocytic differentiation / Tenascin C / Fibronectin / 細胞死アポトーシス / 顆粒球系分化 / 単球系分化 / インテグリンVLA-5 / シアル酸転移酵素-I / インテグリン分子VLA-5 / フィブロネクチン / アポトーシス誘導 / Apoptosis susceptibility / Cell cycle / Differentiation expression / Apoptosis inhibitory gene bcl-2 / Tenascin-C / Retinoblastoma gene product (Rb) / ECM糖蛋白テネイシン / bc1-2遺伝子 / アポトーシス誘起 / Rbリン酸化抑制 / 細胞外マトリックス糖蛋白分子 / 水溶性細胞増殖因子EGF / アポトーシス抑制遺伝子bcl-2 / 細胞分化の制御 / アポトーシス感受性 / 分化形質発現 / アポトーシス抑制遺伝子bc1-2 / 細胞外マトリックス(ECM)糖蛋白 / Change Chromatin Structure / Cell Growth Factors / Nonepithelial Stroma Cells / Extracellular Matrix / Glycoprotein Tenascin / E2F Binding Site / cdc2 Gene Product / Cell Cycle / (非)上皮系細胞 / 増殖因子 / 非上皮系間質細胞 / クロマチン構造変化 / E2F結合部位 / (非)リン酸化型Rb / 細胞外マトリックスECM / 糖蛋白テネイシン / TGF-β / tumor-related gangliosides / hemopoietins / -independent / factor-dependent / Interleukins (IL-1, Il-3) / autonomous growth / エレクトロポレ-ション(Electroporation)法 / 高電圧パルス法 / 細胞融合法 / 癌関連抗原ガングリオシドGD3 / ガングリオシドGD3 / 癌関連抗原シアロ糖脂質(GangliosideGD3) / エレクトロポレ-ション法(電気穿孔法) / オ-トクリン(Autocrine)機構 / 造腫瘍性 / 増殖因子(非)依存性 / インタ-ロイキン(ILー1,ILー3) / 自律増殖能 / クローン増殖 / 分化誘導現象 / 分化方向決定機序 / 天然シアロ糖脂質ガングリオシド / シグナル伝達 / 糖鎖構造特異性 / レチノイン酸耐性HL-60変異株 / siRNA / シグナル配列単離法 / Wntファミリー分子 / 膜型糖蛋白分子mKirre / 造血幹細胞・前駆細胞 / D型受容体 / ボツリヌス毒素C型 / ガングリオシド分子種 / 造血幹細胞増幅維持因子 / 造血幹細胞KSL細胞 / LTC-IC法(Long-term culture initiating cell assay) / 浩血支持能 / 膜タンパク分子mKirre / 間葉系細胞 / 間質細胞 / 告血幹細胞増幅維持因子 / Tmtsp / 膜タンパク分子Thsd1 / 告血幹細胞KSL細胞 / 骨髄長期培養法LT-BMC / 大動脈硬化アテローム形成 / 抗癌剤抵抗性 / ヒト肺がん細胞 / ガングリオソーム(gangliosome) / 膜糖蛋白分子mKirre / GM3合成酵素ゲノム構造 / 大動脈硬化アテローム変性 / ガングリオシドGM3合成酵素欠損マウス / 遺伝子発現 / マウスホモローグcDNA / 細胞外マトリックス糖蛋白テネイシン / α2→6シアル酸転移酵素 / シグナル伝達系 / 糖脂質糖鎖 / リン作動性ニユーロン特異的ガングリオシド / N-アセチルガラクトサミニル化 / カルモジュリン依存性酵素 / グリア系細胞 / ポリシアロガングリオシド / 癌関連糖脂質 / 糖脂質完全欠損ミュータント細胞 / GM1合成酵素 / GM3合成酵素 / 糖脂質の末端シアル酸化 / 精子受容体活性 / 糖蛋白糖鎖末端シアル酸 / ARIS硫酸化糖鎖構造 / アセチル転移酵素 / 細胞増殖因子IL-3 / 糖鎖末端ガラクトース / グルコシル転移酵素 / スフィンゴ脂質合成阻害剤 / ガングリオシド抗体 / GD3合成酵素 / アセチルCoAトランスポーターアセチル / ガングリオシドM5 / 受精先体反応 / 糖鎖コア構造 / 糖鎖複合体の分子設計 / 糖鎖複合体の再構成 / 分子認識と接着 / 糖鎖発現の制御因子 / 増殖・分化 / 糖鎖遺伝子クローニング / 糖鎖合成酵素遺伝子 / バイオサイエンス / 糖鎖複合体 / 糖鎖の生物機能 / 国際シンポジウム / 重点領域研究 / 細胞認識・接着 / 糖鎖プローブ / 糖鎖発現制御因子 / 細胞増殖・分化調節 / フラバノン化合物デスマール / アポプトーシス / エンドヌクレアーゼ / 糖転移酵素系 / 非リン酸化RB遺伝子産物 / チロシンキナーゼ阻害剤 / 糖鎖含有リコンビナントD因子 / インスリン受容体βサブユニット自己リン酸化反応 / 造血因子MーCSF / トランスフォ-ミング増殖因子(TGF)β / 活性型ビタミンD3 / 抗癌剤排出性P糖蛋白 / 特異的チロシンキナ-ゼ阻害物質 / 脂質性合成シアロ糖化合物 / 分化誘導剤 / ラット骨髄前脂肪細胞株RECAー16 / アポプト-シス / AraC感受性 / MDS由来細胞株 / ミオシンL鎖キナ-ゼ阻害剤 / 蛋白リン酸化酵素阻害剤 / ピリミジンヌクレオシド化合物 / トリプシン処理 / ガングリオシド代謝 / 単球マクロファ-ジ系分化 / 分化誘導機序 / トリチウム標識 / 生理活性ガングリオシド … More
Except Principal Investigator
ガングリオシド / 糖鎖遺伝子 / 分化誘導療法 / 化学合成 / 神経機能 / 生理活性 / 糖鎖認識プロ-ブ / 造血幹細胞 / 造血因子 / D因子 / M-CSF / NFY / Sp1 / 糖転移酵素 / 糖脂質 / 糖タンパク質 / ハービマイシン / 造血細胞コロニー / 染色体分析 / 白血病 / プロテオグリカン / 酵素阻害剤 / メラノ-マ糖鎖抗原 / 細胞増殖と分化制御 / cーmyc遺伝子 / フレンド白血病細胞 / 分化誘導因子 / シアロ糖化合物 / Myelodysplastic syndrome / Tumor-killing activity / Megakaryocyte-potentiator / Survival rate / Bone Marrow Transplantation / Thrombocytopenia / Granulocytopenia / Chromium Release Assay / 単球活性化 / 血中コレステロ-ル / 無顆粒球症 / 腫瘍壊死因子 / Fc受容体 / 抗体非依存性殺腫瘍活性 / 抗体依存性殺腫瘍活性 / MーCSF / 骨髄異型性症候群 / 殺腫瘍活性 / 巨核球増幅因子 / 生着生存率 / 骨髄移植 / 血小板減少症 / 顆粒球減少症 / lymphocyte differerentiation / hemopoietic stromal cells / megakaryoblastic cell line / insertion of hemopoietic factor genes / hemopoietic factors / hemopoietic stem cells / 単細胞培養 / 無血清培養 / インターリューキン6 / インターリューキン5 / MN血液型 / リンパ球の超源 / 造血支株細胞 / 巨核球性白血病株 / 造血因子遺伝子挿入 / 幹細胞の濃縮 / 染色体 / 発癌ウイルス / 巨核球産生 / インターリユキン5 / リンパ球の起源 / Sanctity of Life / Spirituality / Religious Cultures / Enhancement / Embryonic Stem Cells / Cloning / Organ Transplantation / Brain Death / 生命科学 / 人工生殖 / クローン / 人胚研究 / いのち / インド / スリランカ / 死生観 / 国際宗教学宗教史学会 / 幹細胞 / 再生医療 / 生命倫理 / ヒトES細胞 / 生命倫理の日米比較 / 新生児集中治療 / 遺伝子治療 / インハーンスメント / スピリチュアルケア / ターミナルケア / 死 / <いのち>の尊厳 / スピリチュアリティ / 宗教文化 / エンハンスメント / ヒト胚性幹細胞 / クローン技術 / 臓器移植 / 脳死 / Targetting mice / Genomic organization / transcriptional promoter / GM3 synthase / HL-60細胞 / シアル酸転移酵素 / ガングリオシドGM3 / 抗体 / ゲノムDNA / GH3合成酵素 / ターゲッティングマウス / 遺伝子構造 / 転写プロモーター / GM3合成酵素 / glycosyltransferase / proteoglycan / glycolipid / glycoprotein / glyco-gene / sugar remodeling / glycoconjugate / sugar chain / 糖鎖リモデリング / 複合糖質 / 糖鎖 / Carbohydrate deficience / Mucin / Lectin / Glycosyltransferase / Cell adhesion / Ganglioside / Glycolipid / Glycoprotein / エンドグリコシダ-ゼ / ガラクト-ス転移酵素 / 癌転移 / エンドサイト-シス / マクロファ-ジ / 統転移酵素 / 発生分化 / プロチオグリカン / 統鎖生物学 / 糖鎖欠損 / ムチン / レクチン / 細胞接着 / エリトロポエチン / 赤芽球分化因子 / ガングリオシド類縁体 / TNF 変異体 / インターロイキン6 / ブロメライン / GーCSF / ビタミンD_3誘導体 / 核酸関連化合物 / 分化誘導剤 / 組換ウイルス / 癌細胞分化促進糖鎖 / 糖鎖単クロン抗体 / 血清診断 / 糖鎖合成酵素 / 癌性糖鎖変化 / 癌遺伝子 / ヒト臓器癌 / 細胞膜複合糖質 / 免疫療法 / 抗体療法 / CD82 / KAI1 / 免疫遺伝子治療 / 樹状細胞 / 浸潤 / cDNAマイクロアレイ / 臓器微小環境 / MMP / EGF受容体 / 分子標的治療 / 多臓器転移 / 血管標的薬 / 骨転移 / VEGF受容体 / 癌性胸水 / VEGF / PTHrP / 血管新生 / 肺癌 / がん遺伝子 / 形質転換 / チロシンキナーゼ / ドッキング蛋白質 / 蛋白質リン酸化 / Cas蛋白質 / シグナル入力 / 糖鎖硫酸化 / フコシダーゼ / L-セレクチン / スルフォトランスフェラーゼ / スルホトランスフェラーゼ / 糖鎖シグナル / N-アセチルガラクトサミニルトランスフェラーゼ / 異種抗原 / ミッドカイン / プロテインホスファターゼ / シンデカン / ヘパラン硫酸 / コンドロイチン硫酸 / クローニング / 糖鎖工学 / 糖鎖生物学 / シグナル伝達系 / ヒト骨髄性白血病細胞 / MHCクラスII分子 / コリンイR動性ニューロン / 精子・卵子相互作用 / メラノーマ糖鎖抗原 / イノシトールリン酸化酵素 / 糖鎖認識プローブ / 受容体発現異常 / ltk蛋白質 / c-myc遺伝子 / リン酸化チロシン蛋白質 / NDPキナーゼ / Nm23 / I因子 / イノシト-ルリン酸化酵素 / エクト型蛋白リン酸化酵素 / 精子・卵相互作用 / プロティンキナ-ゼC / 幹細胞性白血病 / ltk遺伝子 / チロシンキナ-ゼ / チロシン水酸化酵素 / ヘマグルチニン / 角化過程 / 精子卵相互作用 / プロテインキナ-ゼC / 染色体相互転座 / 受容体遺伝子 / 細胞内分化因子 / 糖鎖の化学合成 / 糖鎖遺伝子と発現制御 / 神経系の機能調節 / ガングリオシドの生理活性 / インタ-ロイキン / コロニ-刺激因子 / サイトカイン / 分化 / 増殖 / 血球細胞 / 活性化酸素 / 倍数性骨髄性白血病株細胞 / 熱ショック蛋白質 / 分化誘導療法補強剤 / アルキルエーテル非燐脂質 Less
  • Research Projects

    (48 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (86 People)
  •  造血幹細胞の増殖・分化能を維持する骨髄間質細胞由来の膜蛋白分子の分離・同定と応用Principal Investigator

    • Principal Investigator
      齋藤 政樹
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Meiji Pharmaceutical University
  •  ガングリオシドGM3合成酵素(シアル酸転移酵素-1:ST3GalV)の遺伝子発現制御とその生物機能の応用Principal Investigator

    • Principal Investigator
      齋藤 政樹
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Meiji Pharmaceutical University
  •  Research on Brain Death and Organ Transplantation from the Perspective of Comparative Religion

    • Principal Investigator
      MACHIDA Soho
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Religious studies
    • Research Institution
      Tokyo University of Foreign Studies
  •  Functions of Complex Glycosphingolipids in the Cell Proliferation, Differentiation, and Cell Death Controlled at the Gene Level of Their Synthesizing Enzymes, and Their Medical ApplicationsPrincipal Investigator

    • Principal Investigator
      SAITO Masaki
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Meiji Pharmaceutical University
  •  がん特異的リン酸化基質Casによる癌化・転移の制御

    • Principal Investigator
      堺 隆一
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  肺がんの転移・血管新生分子を標的とした生物学的制御法開発

    • Principal Investigator
      曽根 三郎
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  制癌の標的分子としての糖脂質糖鎖遺伝子(ガングリオシドGM3合成酵素遺伝子)Principal Investigator

    • Principal Investigator
      齋藤 政樹
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  制癌の標的分子としての糖脂質糖鎖遺伝子(ガングリオシドGM3合成酵素遺伝子)Principal Investigator

    • Principal Investigator
      齋藤 政樹
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  糖鎖シグナルによる細胞間コミュニケーションの制御

    • Principal Investigator
      村松 喬
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Nagoya University
  •  Sugar remodeling and cellular communication

    • Principal Investigator
      TANIGUICHI Naoyuki
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Osaka University
  •  Expression Mechanism and Its Medical Application of Ganglioside GM3 Synthase Gene Which Is Relevantly Related With Growth and Differentiation of Hematopoietic CellsPrincipal Investigator

    • Principal Investigator
      SAITO Masaki
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      National Cancer Center Research Institute
  •  Study on Ganglioside GM3 Synthase and Its Gene.

    • Principal Investigator
      ISHII Atushi
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      National Cancer Center Research Institute
  •  糖鎖遺伝子とその生物機能Principal Investigator

    • Principal Investigator
      斎藤 政樹 (斉藤 政樹)
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
      Jichi Medical University
  •  制癌の標的分子としての複合糖質糖鎖Principal Investigator

    • Principal Investigator
      斎藤 政樹
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
  •  糖鎖デザインと細胞機能ネットワーク

    • Principal Investigator
      谷口 直之
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka University
  •  Exploitation on Biological Activities of Sialoglycosphingolipids and Their Synthetic Family Compounds (Neoglycollipids)Principal Investigator

    • Principal Investigator
      SAITO Masaki
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      広領域
    • Research Institution
      National Cancer Center Research Institute
      Hokkaido University
  •  Glyco-Signals in Regulatory Mechanisms For Proliferation, Differentiation, Senescence And Apoptosis of Hematopoietic Cells.Principal Investigator

    • Principal Investigator
      SAITO Masaki
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Hokkaido University
  •  Regulatory Mochanisms For Proliferation, Differentiation, And Apoptosis of Leukemic Cells In Reference To Cell Cycle Phases.Principal Investigator

    • Principal Investigator
      SAITO Masaki
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Hokkaido University
      Jichi Medical University
  •  糖鎖と増殖・分化Principal Investigator

    • Principal Investigator
      斎藤 政樹 (斉藤 政樹)
    • Project Period (FY)
      1993 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hokkaido University
      Jichi Medical University
  •  細胞分化誘導剤の臨床応用に関する基礎的研究Principal Investigator

    • Principal Investigator
      斉藤 政樹
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Jichi Medical University
  •  正常造血幹細胞,造血因子と造血器腫瘍との比較と相互関係

    • Principal Investigator
      穂積 本男
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Research Institute for Clinical Oncology, Saitama Cancer Center
  •  ガングリオシド糖鎖情報の解読と細胞機能の制御

    • Principal Investigator
      永井 克孝
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  糖鎖遺伝子とその生物活性Principal Investigator

    • Principal Investigator
      斉藤 政樹
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Institution
      Jichi Medical University
  •  Effects of cdc2 gene and EMC tenasc in on regulation of growth and differentiation of hematopoietic cellsPrincipal Investigator

    • Principal Investigator
      SAITO Masaki
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
  •  細胞分化誘導剤の臨床応用に関する基礎的研究Principal Investigator

    • Principal Investigator
      斎藤 政樹
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Jichi Medical University
  •  正常造血幹細胞,造血因子と造血器腫瘍との比較と相互関係

    • Principal Investigator
      穂積 本男
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Research Institute for Clinical Oncology, Saitama Cancer Center
  •  ガングリオシド糖鎖情報の解読と細胞機能の制御

    • Principal Investigator
      永井 克孝
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  New Development in glycobiology

    • Principal Investigator
      MURAMATSU Takashi
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      物質生物化学
    • Research Institution
      Nagoya University School of Medicine
      Kagoshima University
  •  正常造血幹細胞,造血因子と造血器腫瘍との比較と相互関係

    • Principal Investigator
      穂積 本男
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Research Institute for Clinical Oncology, Saitama Cancer Center
  •  ガングリオシド糖鎖の生理活性

    • Principal Investigator
      永井 克孝
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  ガングリオシド糖鎖情報の解読と細胞機能の制御

    • Principal Investigator
      永井 克孝
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  ガングリオシド糖鎖の生理活性

    • Principal Investigator
      永井 克孝
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  ガングリオシド糖鎖の生理活性

    • Principal Investigator
      永井 克孝
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Studies on Expression-Mechanism (s) of Malignant Phenotypes Using Growth-Factor Gene-Transfer MethodsPrincipal Investigator

    • Principal Investigator
      SAITO Masaki
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
  •  新しい分化誘導療法剤の開発と分化誘導療法の基礎的研究

    • Principal Investigator
      穂積 本男
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Research Institute for Clinical Oncology, Saitama Cancer Center
  •  血球細胞の増殖と分化に関する基礎的臨床的研究

    • Principal Investigator
      高久 史磨
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Hematology
    • Research Institution
      The University of Tokyo
  •  ガングリオシドの糖鎖情報の解読と細胞機能の制御

    • Principal Investigator
      NAGAI Yoshitaka
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Institution
      The University of Tokyo
  •  シアロ糖化合物による制癌(白血病細胞増殖抑制・分化誘導)機構の解析と応用:生理活性ガングリオシドGM3の取込み、分布、代謝Principal Investigator

    • Principal Investigator
      斎藤 政樹
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  シロア糖脂質(ガングリオシド)及び有機合成類似体による制癌の試み:抗白血病作用の特異的分子機構の解析Principal Investigator

    • Principal Investigator
      斎藤 政樹
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Jichi Medical University
  •  新しい分化誘導療法剤の開発と分化誘導療法の基礎的研究

    • Principal Investigator
      穂積 本男
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Research Institute for Clinical Oncology, Saitama Cancer Center
  •  Functional activation of human monocytes by recombinant human macrophage colony-stimulating factor.

    • Principal Investigator
      MOTOYOSHI Kazuo
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
  •  新しい分化誘導剤の開発と分化誘導療法の基礎的研究

    • Principal Investigator
      穂積 本男
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Research Institute for Clinical Oncology, Saitama Cancer Center
  •  Autocrine Proliferation and Differentiation-Capacities of Leukemic Cells, and Molecular Analyses of Leukemic PhenotypesPrincipal Investigator

    • Principal Investigator
      SAITO Masaki
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
  •  癌の細胞膜糖鎖変化の機構とその応用に関する研究

    • Principal Investigator
      牧田 章
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hokkaido University
  •  造血幹細胞の分化と白血病はどのようにかかわりをもつか?

    • Principal Investigator
      三浦 恭定
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Jichi Medical University
  •  Studies on multipotent stem cell clifferentiation using newly developed techniques an its clinical applications.

    • Principal Investigator
      MIURA Yasusada
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Hematology
    • Research Institution
      JICHI MEDICAL SCHOOL
  •  Bioactive Sialoglycosphingolipids(Gangliosides) and Their Related Amphipathic Sialoglycocompounds:Fundamental Studies and Applications of Anti-Leukemic(Differentiation-Inducing) ActivitiesPrincipal Investigator

    • Principal Investigator
      SAITO Masaki
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School
  •  Establishment of Hemopoietic Stem Cell Lines By Introduction of Oncogenes and Biochemical Studies on Mechanisms of Hemopoietic Cell Differentiation Using the Established Cell LinesPrincipal Investigator

    • Principal Investigator
      SAITO Masaki
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical School

All 2007 2006 2005 2003 2002 Other

All Journal Article Book

  • [Book] Glycosyltransferases, ST3GalV (Ganglioside GM3 Synthase).2002

    • Author(s)
      Saito, M., Ishii, A.
    • Total Pages
      11
    • Publisher
      Springer-Verlag, New York-London-Tokyo
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370310
  • [Journal Article] Differential Development of Carbachol-Induced Desensitiz- ation in Receptor-Mediated Ca2+ Influx and Ca2+ Release Pathways in Smooth Muscle of Guinea-Pig Taenia Caeci.2007

    • Author(s)
      Hishinuma, S., Matsumoto, Y., Sato, R., Saito,M.
    • Journal Title

      Clin.Exp.Pharmacol.Physiol. 34

      Pages: 191-197

    • Data Source
      KAKENHI-PROJECT-16659259
  • [Journal Article] Endogenously produced ganglioside GM3 endows etoposide and doxorubicin resistance by up-regulating Bcl-2 expression in 3LL Lewis lung carcinoma cells.2006

    • Author(s)
      Noguchi, M., Saito, M., Inokuchi, J., et al.
    • Journal Title

      Glycobiology 16(7)

      Pages: 641-650

    • Data Source
      KAKENHI-PROJECT-16659259
  • [Journal Article] Differential roles of ryanodine- and thapsigargin-sensitive intracellular Ca^<2+> stores in excitation-contraction coupling in smooth muscle of guinea-pig taenia caeci.2006

    • Author(s)
      Hishinuma.S., Saito.M.
    • Journal Title

      Clin.Exp.Pharmacol.Physiol. 33

      Pages: 1138-1143

    • Data Source
      KAKENHI-PROJECT-16659259
  • [Journal Article] Substitution of the N-glycan function in glycosyltransfer- ases by specific amino acids : ST3Gal-V as a model enzyme.2006

    • Author(s)
      Uemura, S., Saito, M., Inokuchi, J., et al.
    • Journal Title

      Glycobiology 16(3)

      Pages: 258-270

    • Data Source
      KAKENHI-PROJECT-16659259
  • [Journal Article] Overexpression of GM3 synthase in human atherosclerotic plaque : possible involvement of ganglioside GM3 in atherogenesis.2006

    • Author(s)
      Bobryshev, Y.V., Saito, M., Prokazova, N., et al.
    • Journal Title

      Atherosclerosis 184(1)

      Pages: 63-71

    • Data Source
      KAKENHI-PROJECT-16659259
  • [Journal Article] Overexpression of GM3 synthase in human atherosclerotic plaque : possible involvement of ganglioside GM3 in atherogenesis.2005

    • Author(s)
      Bobryshev, Y.V., Saito, M., et al.
    • Journal Title

      Atherosclerosis (in press)

    • Data Source
      KAKENHI-PROJECT-14030085
  • [Journal Article] Three transcripts (L-,B1- and B2-type)for ganglioside GM3 synthase (SAT-1/ST3GalV)detectable in mice with L-type produced by parenchymal hepatocytes but not by mesenchymal Kupffer cells.2005

    • Author(s)
      Ishiyama-Sato, K., Saito, M., et al.
    • Journal Title

      Biochim.Biophys.Acta (Lipid-Lipid Met) (in press)

    • Data Source
      KAKENHI-PROJECT-16659259
  • [Journal Article] ヒスタミンH_1受容体の細胞内移行と薬物感受性変化2005

    • Author(s)
      菱沼 滋, 齋藤政樹
    • Journal Title

      日薬理誌 125

      Pages: 251-258

    • NAID

      10016428830

    • Data Source
      KAKENHI-PROJECT-16659259
  • [Journal Article] Overexpression of GM3 synthase in human atherosclerotic plaque : : possible involvement of ganglioside GM3 in atherogenesis.2005

    • Author(s)
      Bobryshev, Y.V., Saito, M., et al.
    • Journal Title

      Atherosclerosis (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370310
  • [Journal Article] Overexpression of GM3 synthase in human atherosclerotic plaque : possible involvement of ganglioside GM3 in atherogenesis.2005

    • Author(s)
      Bobryshev, Y.V., Saito, M., et al.
    • Journal Title

      Atherosclerosis (in press)

    • Data Source
      KAKENHI-PROJECT-14370310
  • [Journal Article] Binding of Clostridium botulinum Type C and D Neurotoxins to Ganglioside and Phospholipid : Novel insights into the receptor for clostridial neurotoxins2005

    • Author(s)
      Tsukamoto, K., Saito, M., Kozaki, S., et al.
    • Journal Title

      J.Biol.Chem. 280(42)

      Pages: 35164-35171

    • Data Source
      KAKENHI-PROJECT-16659259
  • [Journal Article] Augmentation of_<-1>-adrenoceptor-mediated contraction by warming without increased phosphorylation of myosin in rat caudal arterial smooth muscle.2005

    • Author(s)
      Mita, M., Walsh, M.P., Saito, M.
    • Journal Title

      J.Pharmacol.Sci. 99

      Pages: 61-67

    • Data Source
      KAKENHI-PROJECT-16659259
  • [Journal Article] Overexpression of GM3 synthase in human atherosclerotic plaque : possible involvement of ganglioside GM3 in atherogenesis.2005

    • Author(s)
      Bobryshev, Y.V., Saito, M., et al.
    • Journal Title

      Atherosclerosis (in press)

    • Data Source
      KAKENHI-PROJECT-16659259
  • [Journal Article] Three transcripts (L-, B1- and B2-type for ganglioside GM3 synthase (SAT-1/ST3GalV) detectable in mice with L-type produced by parenchymal hepatocytes but not by mesenchymal Kupffer cells.2005

    • Author(s)
      Ishiyama-Sato, K., Saito, M., et al.
    • Journal Title

      Biochim.Biophys.Acta (Lipid-Lipid Met) (in press)

    • Data Source
      KAKENHI-PROJECT-14370310
  • [Journal Article] Three transcripts (L-,B1- and B2-type)for ganglioside GM3 synthase (SAT-1/ST3GalV)detectable in mice with L-type produced by parenchymal hepatocytes but not by mesenchymal Kupffer cells.2005

    • Author(s)
      Ishiyama-Sato, K., Saito, M., et al.
    • Journal Title

      Biochim.Biophys.Acta (Lipid-Lipid Met) (in press)

    • Data Source
      KAKENHI-PROJECT-14030085
  • [Journal Article] A stromal cell-derived membrane protein that supports hematopoietic stem cells.2003

    • Author(s)
      Ueno, H., Saito, M., et al.
    • Journal Title

      Nature Immunology 4・5

      Pages: 457-463

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370310
  • [Journal Article] A stromal cell-derived membrane protein that supports hematopoietic stem cells.2003

    • Author(s)
      Ueno, H., Saito, M., et al.
    • Journal Title

      Nature Immunol. 4/5

      Pages: 457-463

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370310
  • [Journal Article] Ganglioside GM3 Overexpression Induces Apoptosis and Reduces Malignant Potential in Murine Bladder Cancer.2002

    • Author(s)
      Watanabe, R., Saito, M., et al.
    • Journal Title

      Cancer Res. 62

      Pages: 3850-3854

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370310
  • [Journal Article] Ganglioside GM3 participates in the pathological conditions of insulin resistance.2002

    • Author(s)
      Tagami, S., Saito, M., et al.
    • Journal Title

      J.Biol.Chem. 277

      Pages: 3085-3092

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370310
  • [Journal Article] Ganglioside GM3 overexpression Induces Apoptosis and Reduces Malignant Potential in Murine Bladder Cancer.2002

    • Author(s)
      Watanabe, R., Saito, M., et al.
    • Journal Title

      Cancer Res. 62

      Pages: 3850-3854

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370310
  • [Journal Article] Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase.2002

    • Author(s)
      Mita, M., Saito, M., et al.
    • Journal Title

      Biochem.J. 364

      Pages: 431-440

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370310
  • [Journal Article] Differential regulation of cell migration, actin stress fiber organization andcell transformation by functional domains of Crk-associated substrate (Cas).2002

    • Author(s)
      Huang, J., Saito, M., et al.
    • Journal Title

      J.Biol.Chem. 277

      Pages: 27265-27272

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370310
  • [Journal Article] Differential regulation of cell migration, actin stress fiber organization and cell transformation by functional domains of Crk-associated substrate(Cas).2002

    • Author(s)
      Huang, J., Saito, M, et al.
    • Journal Title

      J.Biol.Chem. 277

      Pages: 27265-27272

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370310
  • [Journal Article] Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines.2002

    • Author(s)
      Miyake, I., Saito, M., et al.
    • Journal Title

      Oncogene 21

      Pages: 5823-5834

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370310
  • [Journal Article] Overexpression of GM3 synthase in human atherosclerotic plaque : possible involvement of ganglioside GM3 in atherogenesis.

    • Author(s)
      Bobryshev, Y.V., Saito, M., et al.
    • Journal Title

      Atherosclerosis (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370310
  • 1.  OHTA Masatsugu (90160514)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 2.  NAGAI Yoshitaka (80072974)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 3.  SUZUKI Akemi (70134533)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 4.  KITAGAWA Sei-ichi (50133278)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 5.  穂積 本男 (50113478)
    # of Collaborated Projects: 8 results
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  • 27.  HISHINUMA Shigeru (70211505)
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  • 28.  ARAI Keiko (90312074)
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  • 30.  水野 左敏 (60072930)
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  • 33.  帯刀 益夫 (10099971)
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  • 35.  竹縄 忠臣 (40101315)
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  • 36.  辻 崇一 (90124677)
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  • 44.  渡辺 利雄 (60201208)
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  • 45.  青柳 高明 (10159303)
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  • 48.  山科 郁男 (70025675)
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  • 84.  上田 紀行 (40211768)
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  • 85.  樋野 興夫 (90127910)
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    # of Collaborated Products: 0 results
  • 86.  ITOH Masayoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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