HASE Sumihiro 長谷純宏

Researcher Number	80028232
External Links
Affiliation (based on the past Project Information) *help	2004 – 2005: 大阪大学, 大学院・理学研究科, 教授 1998 – 2000: 大阪大学, 大学院・理学研究科, 教授 1997 – 1998: 大阪大学, 大学院理学研究科, 教授 1989 – 1995: 大阪大学, 理学部, 教授 1988: Osaka University College of Science, Associate Prof., 理学部, 助教授 1987: 大阪大学, 理学部, 講師
Review Section/Research Field	Principal Investigator 物質生物化学 / Structural biochemistry / Functional biochemistry / Structural biochemistry Except Principal Investigator 物質生物化学 / Structural biochemistry
Keywords	Principal Investigator 糖鎖 / HPLC / ピリジルアミノ化 / 糖蛋白質 / 蛍光標識 / オリゴ糖 / 酵素 / 脳 / ピリジルアミノ化法 / 人工複合糖質 … More / 2次元マップ / Sugar chain / Fluorescence labeling / マンノシダ-ゼ / 基質特異性 / マンノシダーゼ / ニワトリ / Glycoprotein / Pyridylamination / ウズラ / 輸卵管 / コバルト / 逆相 / ピリジアルアミノ化 / マウス / 二次元マップ / ゼブラフィッシュ / ルイスX / O^ー配糖体 / ヒドラジレ分解 / Oー配糖体 / ヒドラジン分解 / O-Sugar chain / Hydrazinolysis / キシロシルグルコース / キシロ-ス / 尿 / 肝臓 / 少糖 / Xylosylglucose / コバルトイオン / ピリジルアミニ化法 / mannosidase / sugar chain / cobalt / hen / pyridylamination / ビリジルアシノ化 / 部分水解 / 構造 / ピソジルアミノ化 / 2D-map / Pyridylaminotion / oligosaccharide / partial acid hydrolysis / Sturcfure / 糖タンパク質 / Fluorescent labeling / Glycoproteins / 2-Dimensiona map / 糖組成分析 / Component sugar analysis … More Except Principal Investigator 細胞移動 / 糖タンパク質 / 糖脂質 / 糖転移酵素 / 血液凝固VII因子 / 血液凝固IX因子 / 外因系凝固反応 / プロテインZ / 糖ペプチド / キシロ-ズ / グルコ-ス / 上皮細胞増殖成長因子(EGF) / 糖鎖解析 / リ-ラ-マウス / ピリビルアミノ化 / グルコース転移酵素 / 神経芽細胞 / グルコシルセラミド / リーラマウス / N-結合型糖鎖 / 糖鎖自動分析 / HPLC / 蛍光標識 / ヒドラジン分解 / ガングリオシド / 細胞接着 / レクチン / ムチン / 糖鎖欠損 / 統鎖生物学 / プロチオグリカン / 発生分化 / 統転移酵素 / マクロファ-ジ / エンドサイト-シス / 癌転移 / ガラクト-ス転移酵素 / エンドグリコシダ-ゼ / Glycoprotein / Glycolipid / Ganglioside / Cell adhesion / Glycosyltransferase / Lectin / Mucin / Carbohydrate deficience / エンド型グリコシダーゼ / 糖転移反応 / ペプチドへの糖鎖導入 / 糖鎖の切り出し / 複合糖質 / 橋渡し部分 / 糖鎖工学 / プロテオグリカン / 糖鎖切り出し / 糖鎖組み換え / 糖鎖限定分解 / endo-type glycosidase / transglycosylation / carbohydrate transferation in to peptide / cutting out carbohydrate chain / glycoconjugate / linkage region / glycotechnology / キシロース転移酵素 / 血液凝固 / EGF様ドメイン / 糖鎖 / 糖鎖合成 / キシロシル-グルコース / 血液凝固因子 / EGFドメイン / 合成酵素 / SUGAR TRANSFERASE / XYLOSYLTRANSFERASE / BLOOD COAGULATION / EGF-LIKE DOMAIN / SUGAR CHAIN / SYNTHESIS OF SUGAR CHAIN / XYLOSYL-GLUCOSE / BLOOD COAGULATION FACTOR Less

神経胚中期に現れるルイスX構造の意義Principal Investigator
- Principal Investigator
  
  長谷純宏
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
ビリジルアミノ化法を用いた精密人工複合糖質の作成Principal Investigator
- Principal Investigator
  
  長谷純宏
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
ピリジルアミノ化法を用いた精密人工複合糖質の作成Principal Investigator
- Principal Investigator
  
  長谷純宏
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
脳特異的糖鎖BA2の生理学的意義の解明
- Principal Investigator
  
  池中一裕
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Okazaki National Research Institutes
Analysis of Oligosaccharide Structures from the Reducing End Terminal by Combining Partial Acid Hydrolysis and a Two-Dimensional Sugar MapPrincipal Investigator
- Principal Investigator
  
  HASE Sumihiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Osaka University
PURIFICATION OF AN ENZYME SYNTHESIZING Z SUGAR CHAIN CHARACTERISTIC TO EGF-LIKE DOMAINS OF PROTEINS ASSOCIATED WITH BLOOD COAGULATION
- Principal Investigator
  
  OMICHI Kaoru
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  OSAKA WOMEN'S UNIVERSITY
ピリジルアミノ化法を用いた精密人工複合糖質の作成Principal Investigator
- Principal Investigator
  
  長谷純宏
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Developments in the new glycotechnology using the specific activity of endo-glycosidases
- Principal Investigator
  
  ENDO Masahiko
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Structural biochemistry
- Research Institution
  Hirosaki University
ピリジルアミノ化法を用いた脳特異的糖鎖の構造解析と脳内分布Principal Investigator
- Principal Investigator
  
  長谷純宏
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
ピリジルアミノ化法を用いた脳特異的糖鎖の構造解析と脳内分布Principal Investigator
- Principal Investigator
  
  長谷純宏
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
ピリジルアミノ化法を用いた脳特異的糖鎖の構造解析と脳内分布Principal Investigator
- Principal Investigator
  
  長谷純宏
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
マウス大脳皮質形成における細胞外グルコース転移酵素の役割
- Principal Investigator
  
  池中一裕
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okazaki National Research Institutes
Analysis of activation of neutral alpha-mannosidase activated with Co(II)Principal Investigator
- Principal Investigator
  
  HASE Sumihiro
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka University
蛍光標識少糖による蛋白質の糖鎖構造認識の解析Principal Investigator
- Principal Investigator
  
  長谷純宏
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
New Development in glycobiology
- Principal Investigator
  
  MURAMATSU Takashi
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  物質生物化学
- Research Institution
  Nagoya University School of Medicine
  Kagoshima University
Search for xylosylglucose-type sugar chains by pyridylaminationPrincipal Investigator
- Principal Investigator
  
  HASE Sumihiro
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  Osaka University
蛍光標識少糖による蛋白質の糖鎖構造認識の解析Principal Investigator
- Principal Investigator
  
  長谷純宏
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
蛍光標識少糖による蛋白質の糖鎖構造認識の解析Principal Investigator
- Principal Investigator
  
  長谷純宏
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
血液凝固VII因子及びIX因子に発見された新しいSer結合型糖鎖の構造と機能解析
- Principal Investigator
  
  岩永貞昭
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Kyushu University
大脳皮質形成の分子機構の解明
- Principal Investigator
  
  池中一裕
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Sensitive analysis of O-linked sugar chains by fluorescence labelingPrincipal Investigator
- Principal Investigator
  
  HASE Sumihiro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  Osaka University
Structure analysis of glycoproteins by two dimensional HPLC mapping with high sensitivityPrincipal Investigator
- Principal Investigator
  
  HASE Sumihiro
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  Osaka University
Practical Application of Fluorescence Labeling to Component Sugar Analysis of GlycoproteinsPrincipal Investigator
- Principal Investigator
  
  HASE Sumihiro
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  物質生物化学
- Research Institution
  Osaka University

All 2005 2004

All Journal Article Book

[Book] Advances in Plant Physiology Vol.72004
- Author(s)
  Ishimizu, T., Hase, S.
- Publisher
  Pectin biosynthesis(in press)
- Data Source
  KAKENHI-PROJECT-16657030
[Journal Article] Alteration of Brain Type N-Glycans in Neurological Mutant Mouse Brain2005
- Author(s)
  S.Nakakita, S.Natsuka, J.Okamoto, K.Ikenaka, S.Hase
- Journal Title
  
  J.Biochem. 138(3)
  
  Pages: 277-283
- NAID
  10017346999
- Data Source
  KAKENHI-PROJECT-16657030
[Journal Article] Changes in N-Linked Suger Chain Patterns Induced by Moderate-to-High Expression of the Galactosyltransferase I Gene in a Brain-Derived Cell Line, CG42005
- Author(s)
  K.N.Menon, T.Ikeda, I.Fujimoto, H.Narimatsu, S.Nakakita, S.Hase, K.Ikenaka
- Journal Title
  
  J.Neurosci.Res. 80(1)
  
  Pages: 29-36
- Data Source
  KAKENHI-PROJECT-16657030
[Journal Article] Expression of Complex-type N-glycans in Developmental Periods of Zebrafisch Embryo2005
- Author(s)
  T.Takemoto, S.Natsuka, S.Nakakita, S.Hase
- Journal Title
  
  Glycoconjugate J. 22
  
  Pages: 20-26
- Data Source
  KAKENHI-PROJECT-16657030
[Journal Article] Characterization of Wheat Germ Agglutinin Ligand on Soluble Glycoproteins in Caenorhabditis elegans2005
- Author(s)
  S.Natsuka, M.Kawaguchi, Y.Wada, A.Ichikawa, K.Ikura, S.Hase
- Journal Title
  
  J.Biochem. 138(2)
  
  Pages: 209-213
- NAID
  10017346737
- Data Source
  KAKENHI-PROJECT-16657030
[Journal Article] Chemical Synthesis of uridine 51-diphospho-a-D-xylopyranose Tetrahedron Asymmetry2005
- Author(s)
  T.Ishimizu, T.Uchida, K.Sano, S.Hase
- Journal Title
  
  Tetrahedron Asymmetry (in press)
- Data Source
  KAKENHI-PROJECT-16657030
[Journal Article] Substrate Specificity and Molecular Cloning of Endo-β-Mannosidase Acting on N-Glycan in Lilium longiflorum2005
- Author(s)
  A.Sasaki, T.Ishimizu, S.Hase
- Journal Title
  
  J.Biochem 137(1)
  
  Pages: 87-93
- Data Source
  KAKENHI-PROJECT-16657030
[Journal Article] Substrate Recognition by Sugar Chain-Related Enzymes : Recognition of a Large Area of Substrates and Its Stricteness and Tolerance2005
- Author(s)
  T.Ishimizu, S.Hase
- Journal Title
  
  TIGG 97(17)
  
  Pages: 215-227
- NAID
  10016881981
- Data Source
  KAKENHI-PROJECT-16657030
[Journal Article] Synthesis of β-mannosides Using the Transglycosylation Activity of Endo-β-mannosidase from Lilium longiflorum2005
- Author(s)
  A.Sasaki, T.Ishimizu, R.Geyer, S.Hase
- Journal Title
  
  FEBS Journal 272(7)
  
  Pages: 1660-1668
- Data Source
  KAKENHI-PROJECT-16657030
[Journal Article] Endo-beta-mannosidase, a Plant Enzyme Acting on N-Glycan : Purification2004
- Author(s)
  T.Ishimizu, A.Sasaki, S.I.Okutani, M.Maeda, M.Yamagishi, S.Hase
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 38555-38562
- Data Source
  KAKENHI-PROJECT-16657030
[Journal Article] Synthesis and Conformational Characterization of the Epidermal Growth Factor-like Domain of Blood Coagulation Factor IX Carrying Xylosyl-glucose2004
- Author(s)
  M.Kitamura, H.Hojo, Y.Nakahara, T.Ishimizu, S.Hase
- Journal Title
  
  Glycoconjugate J 21
  
  Pages: 197-203
- Data Source
  KAKENHI-PROJECT-16657030

1. 池中一裕 (00144527)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. ENDO Masahiko (20004616)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. MURAMATSU Takashi (00030891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. IRIMURA Tatsuro (80092146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KAWASAKI Toshisuke (50025706)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. NAGAI Yoshitaka (80072974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SAITO Masaki (60012762)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ITO Makoto (40253512)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YAMAMOTO Kenji (70109049)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ITO Kazuo (20183171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TAKEGAWA Kaoru (50197282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OMICHI Kaoru (90028259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IKENAKA Tokuji (20028088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 岩永貞昭 (90029942)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 太和田勝久 (20029507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 御子柴克彦 (30051840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 藤本一朗 (70264710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 牧田章 (60004561)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 鈴木明身 (70134533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 小川智也 (30087572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 瀬野信子 (40017182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 山科郁男 (70025675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 傘育子 (00184458)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 堀田恭子 (10050402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. TSUKAMOTO Shigehisa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KONDO Akihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KATO Ikunoshin

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HASE Sumihiro 長谷 純宏

Research Projects

Research Products

Co-Researchers

神経胚中期に現れるルイスX構造の意義Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ビリジルアミノ化法を用いた精密人工複合糖質の作成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ピリジルアミノ化法を用いた精密人工複合糖質の作成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

脳特異的糖鎖BA2の生理学的意義の解明

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Analysis of Oligosaccharide Structures from the Reducing End Terminal by Combining Partial Acid Hydrolysis and a Two-Dimensional Sugar MapPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

PURIFICATION OF AN ENZYME SYNTHESIZING Z SUGAR CHAIN CHARACTERISTIC TO EGF-LIKE DOMAINS OF PROTEINS ASSOCIATED WITH BLOOD COAGULATION

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ピリジルアミノ化法を用いた精密人工複合糖質の作成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Developments in the new glycotechnology using the specific activity of endo-glycosidases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ピリジルアミノ化法を用いた脳特異的糖鎖の構造解析と脳内分布Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ピリジルアミノ化法を用いた脳特異的糖鎖の構造解析と脳内分布Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

ピリジルアミノ化法を用いた脳特異的糖鎖の構造解析と脳内分布Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

マウス大脳皮質形成における細胞外グルコース転移酵素の役割

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Analysis of activation of neutral alpha-mannosidase activated with Co(II)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

蛍光標識少糖による蛋白質の糖鎖構造認識の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

New Development in glycobiology

HASE Sumihiro 長谷純宏