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Ohishi Hirofumi  大石 宏文

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OHISHI Hirofumi  大石 宏文

大石 宏文  オオイシ ヒロフミ

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Researcher Number 00211095
Other IDs
Affiliation (Current) 2025: 京都大学, 薬学研究科, 研究員
Affiliation (based on the past Project Information) *help 2002 – 2005: Osaka University of Pharmaceutical Sciences, Department of Pharmaceutical Sciences, Lecturer, 薬学部, 講師
1997 – 2001: 大阪薬科大学, 薬学部, 助手
1999 – 2000: 大阪薬科大学, 情報科学解析センター, 助手
1993 – 1994: 大阪薬科大学, 薬学部, 助手
Review Section/Research Field
Principal Investigator
Physical pharmacy / Physical pharmacy
Except Principal Investigator
Chemical pharmacy
Keywords
Principal Investigator
ポリアミン / Z-DNA / minor groove / 左巻きZ-DNA / B-Z転移 / Polyamine / B-Z junction / B-Z混合型DNA / マイナーグルーブ / B-Z転移機構 … More / Molecular Dynamics / X-ray crystallography / 発癌機構 / 分子設計 / 相互作用様式 / X-線結晶構造解析 / 核酸 / X線結晶構造解析 / 構造活性相関 / minor groove cavity / B-Z combination crystal / groove binder / B-Z transfer / スーパコイル / 高塩濃度 / 転写 / 三重螺旋 / 結晶構造解析 / 相互作用 / ポリアミンナノワイアー / Z-型DNA / 左巻きDNA / コンフォメーション / モノアミン / DNA / マイナーグルーブキャビテ / グルーブバインダー / long chain left-handed DNA / Left-handed Z-DNA / B-Z transition mechanism / Molecule design / Interaction style / X-ray crystallographic structure analysis / スーパーコイル / ポリアミンナノワイヤー / 超伝導体 / 長鎖Z-DNA / 分子動力学計算 / 長鎖左巻きDNA / molecular design / interaction / salt concentration / left handed Z-DNA / 遺伝子発現制御機構 / 構造科学 / 金属カウンターイオン / コンピューター解析 / 安定化機構 / 塩濃度 / 分子動力学 / 立体構造予測 / 酵素 / コンピュータシュミレーション / x線結晶構造解析 / コンピューターシュミレーション / インターカレーター / スペルミジン / スペルミン … More
Except Principal Investigator
HYDROPHOBIC AMINO ACIDS / DNA-BINDING MOLECULES / DUPLEX DNA / PEPTIDE LIBRARY / SOLID-STATE LIBRARY / COMBINATORIAL CHEMISTRY / DNA結合 / ビスピロール / ビスフラン / ビステトラヒドロフラン / 新規リガンド / DNA配列認識 / 配列選択性 Less
  • Research Projects

    (6 results)
  • Research Products

    (15 results)
  • Co-Researchers

    (3 People)
  •  A structure scientific study about interaction of polyamine and left-handed DNA.Principal Investigator

    • Principal Investigator
      OHISHI Hirofumi
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University of Pharmaceutical Sciences
  •  Molecular Dynamics Calculation and X-ray Crystallographic Study of Interaction mode between Plyamine and Z-DNAPrincipal Investigator

    • Principal Investigator
      OHISHI Hirofumi
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University of Pharmaceutical Sciences
  •  Development of the New Recognition Molecules of DNA Sequences Based on the GC- and AT-Selective Ligands

    • Principal Investigator
      SASAKI Shigeki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Chemical pharmacy
    • Research Institution
      KYUSHU UNIVERSITY
  •  The Structural Studies of Interaction between Polyamine and Z-DNAPrincipal Investigator

    • Principal Investigator
      OHISHI Hirofumi
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University of Pharmaceutical Sciences
  •  DNAと薬物の相互作用に関するX線構造化学、および構造活性相関研究Principal Investigator

    • Principal Investigator
      大石 宏文
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University of Pharmaceutical Sciences
  •  DNAと薬物の相互作用に関するx線構造化学、および構造活性相関研究Principal Investigator

    • Principal Investigator
      大石 宏文
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Physical pharmacy
    • Research Institution
      Osaka University of Pharmaceutical Sciences

All 2006 2005 2004

All Journal Article

  • [Journal Article] Synthesis and properties of 2'-O,4'-C-methylene-oxy-methylene bridged nucleic acid.2006

    • Author(s)
      Hari, Yoshiyuki, Obika, Satoshi, Ohnishi, Ryo, Eguchi, Ken, Osaki, Tomohisa, Ohishi, Hirofumi, Imanishi, Takeshi
    • Journal Title

      Bioorganic & Medicinal Chemistry 14

      Pages: 1029-1038

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] 計算機科学を用いたDNAの創薬化学2006

    • Author(s)
      大石宏文
    • Journal Title

      生産と技術 (印刷中)

    • NAID

      40007273215

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] Intermolecular association model of antifungal polyene macrolide via concerted =C-H... O interaction : X-ray crystal structure analysis and ab initio molecular-orbital calculations of chainin.2006

    • Author(s)
      In, Yasuko, Ohishi, Hirofumi, Miyagawa, Hiroo, Kitamura, Kunihiro, Igarashi, Yasuhiro, Ishida, Toshimasa.
    • Journal Title

      Bulletin of the Chemical Society of Japan 79

      Pages: 126-133

    • NAID

      10017170346

    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] Synthesis and properties of 2'-0,4'-C-methylene-oxy-methylene bridged nucleic acid.2006

    • Author(s)
      Hari, Yoshiyuki, Obika, Satoshi, Ohnishi, Ryo, Eguchi, Ken, Osaki, Tomohisa, Ohishi, Hirofumi, Imanishi, Takeshi
    • Journal Title

      Bioorganic & Medicinal Chemistry 14

      Pages: 1029-1038

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] Antineoplastic Agents. 551. Isolation and Structures of Bauhiniastatins 1-4 from Bauhinia purpurea.2006

    • Author(s)
      Pettit, George R., Numata, Atsushi, Iwamoto, Chika, Usami, Yoshihide, Yamada, Takeshi, Ohishi, Hirofumi, Cragg, Gordon M.
    • Journal Title

      Journal of Natural Products 69

      Pages: 323-327

    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] Intermolecular association model of antifungal polyene macrolide via concerted =C-H… O interactions : X-ray crystal structure analysis and ab initio molecular-orbital calculations of chainin.2006

    • Author(s)
      In, Yasuko, Ohishi, Hirofumi, Miyagawa, Hiroo, Kitamura, Kunihiro, Igarashi, Yasuhiro, Ishida, Toshimasa.
    • Journal Title

      Bulletin of the Chemical Society of Japan 79

      Pages: 126-133

    • NAID

      10017170346

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] Antineoplastic Agents. 551. Isolation and Structures of Bauhiniastatins 1-4 from Bauhinia purpurea.2006

    • Author(s)
      Pettit, George R., Numata, Atsushi, Iwamoto, Chika, Usami, Yoshihide, Yamada, Takeshi, Ohishi, Hirofumi, Cragg, Gordon M
    • Journal Title

      Journal of Natural Products 69

      Pages: 323-327

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] Synthesis and properties of 2'-O,4'-C-methylene-oxy-methylene bridged nucleic acid.2006

    • Author(s)
      Hari, Yoshiyuki, Obika, Satoshi, Ohnishi, Ryo, Eguchi, Ken, Osaki, Tomohisa, Ohishi, Hirofumi, Imanishi, Takeshi.
    • Journal Title

      Bioorganic & Medicinal Chemistry 14

      Pages: 1029-1038

    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] 計算機科学を用いたDNAの創薬化学2006

    • Author(s)
      大石宏文
    • Journal Title

      生産と技術 印刷中

    • NAID

      40007273215

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] The development of crystallization and X-ray crystallography method of long stem DNA2005

    • Author(s)
      Hirofumi Ohishi, Koji Tsukamoto, Mamiko Odoko, Kazimierz Rzeskowiak, Naoyoshi Maezaki, Nobuo Okabe, Tetsuaki Tanaka, Toshimasa Ishida
    • Journal Title

      Nucleic Acids Research Supplement

      Pages: 67-68

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] Stabilization of the left-handed Z-DNA with monoamines and polyamines2005

    • Author(s)
      Koji Tsukamoto, Mamiko Odoko, Hirofumi Ohishi, Yoichi Hiyama, Naoyoshi Maezaki, Nobuo Okabe, Tetsuaki Tanaka, Toshimasa Ishida
    • Journal Title

      Nucleic Acids Research Supplement

      Pages: 251-252

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] The development of crystallization and X-ray crystallographyh method of long stem DNA2005

    • Author(s)
      Hirofumi Ohishi, Koji Tsukamoto, Mamiko Odoko, Kazimierz Grzeskowiak, Naoyoshi Maezaki, Nobuo Okabe, Tetsuaki Tanaka, Toshimasa Ishida
    • Journal Title

      Nucleic Acids Research Supplement

      Pages: 67-68

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] The X-ray crystallographic study of the conformation of Z-DNA which bound to polyamine for the minor groove at room temperature and low temperature2004

    • Author(s)
      Hirofumi Ohishi, Toshimasa Ishida, Kenji Suzuki, Kazimierz Grzeskowiak, Mamiko Odoko, Nobuo Okabe
    • Journal Title

      Nucleic Acids Research S2

      Pages: 256-257

    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] Berberine/γ-cyclodextrin inclusion structure studied by 1H-NMR spectroscopy and molecular-dynamics calculations.2004

    • Author(s)
      Kamigauchi, Miyoko, Kanbara, Narumi, Sugiura, Makiko, Iwasa, Kinuko, Ohishi, Hirofumi, Ishida, Toshimasa.
    • Journal Title

      Helvetica Chimica Acta 87

      Pages: 264-271

    • Data Source
      KAKENHI-PROJECT-15590051
  • [Journal Article] Asymmetric Intramolecular Michael Addition of α-Sulfinyl Vinylic Carbanion to Enoates.2004

    • Author(s)
      Maezaki, Naoyoshi, Sawamoto, Hiroaki, Yuyama, Sachiko, Yoshigami, Ryoko, Suzuki, Tomoko, Izumi, Mayuko, Ohishi, Hirofumi, Tanaka, Tetsuaki.
    • Journal Title

      Journal of Organic Chemistry 69

      Pages: 6335-6340

    • Data Source
      KAKENHI-PROJECT-15590051
  • 1.  SASAKI Shigeki (10170672)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  NAGATSUGI Fumi (90208025)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  TORIGOE Hidetaka (80227678)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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