Ishii Satoshi 石井達

… Alternative Names

ISHII Satoshi 石井達

石井達イシイサトシ

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Researcher Number	00222935
Other IDs
Affiliation (Current)	2025: 大分大学, 医学部, 客員研究員
Affiliation (based on the past Project Information) *help	2021 – 2024: 大分大学, 医学部, 客員研究員 2009 – 2019: Oita University, 医学部, 客員研究員 2014: 大分大学, 医学部, 研究員 2011 – 2012: 大分大学, 医学部, 研究員 2008: Obihiro University of Agriculture and Veterinary Medicine, 畜産学部, 教授 … More 2005: 帯広畜産大学, 畜産学部, 教授 1993: 財団法人東京都臨床医学総合研究所, 臨床遺伝学研究部門, 研究員 1993: The Tokyo Metropolitan Institute of Medical Science, Department of Clinical Gene, 臨床遺伝学研究部門, 研究員 1991 – 1993: 東京都臨床医学総合研究所, 臨床遺伝学, 研究員 1992: (財)東京都臨床医学総合研究所, 臨床遺伝学研究部門, 研究員 1991: 財団法人東京都臨床医学総合研究所, 臨床遺伝学研究部門, 研究員 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Pathological medical chemistry Except Principal Investigator Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 53040:Nephrology-related / Basic veterinary science/Basic zootechnical science / Pediatrics / Kidney internal medicine
Keywords	Principal Investigator 応用動物 / シャペロン療法 / ファブリー病 / アミノ酸置換 / シグナル配列 / alpha-ガラクトシダーゼ Except Principal Investigator フォールディング / シャペロン / イミノ糖 / グリコシダーゼ … More / リソソーム病 / 遺伝子変異 / 酵素補充療法 / テイ-サックス病 / テイーサックス病 / ファブリー病 / 保護蛋白質 / ガラクトシアリドーシス / シャペロン療法 / ポンペ病 / Forssman-glycolipid / glycogene / fowls / sugar-chains / animal husbandry / evolution / glycosyltransferase / genome / 糖糖遺伝子 / フォルスマン糖脂質 / 糖鎖遺伝子 / 家禽類 / 糖鎖 / 畜産学 / 進化 / 糖転移酵素 / ゲノム / protective protein / galactosialidosis / confocal laser scanning microscopy / enzyme replacement therapy / baculovirus / alpha-galactosidase / Fabry disease / gene expression / 遺伝子解析 / 遺伝子大量発現 / αーガラクトシダ-ゼ / ファブリ-病 / レーザー走査型共焦点顕微鏡 / キメラ蛋白 / 先天代謝異常症 / alpha-ガラクトシダーゼ / 共焦点レーザー走査型顕微鏡 / バキュロウイルス / α-ガラクトシダーゼ / フィブリー病 / 遺伝子発現 / 心不全 / p62 / オートファジー不全 / Gb3 / lamellar body / Uromodulin / TAL / ファブリー腎症 / 成長障害 / 骨粗鬆症 / ヘンレ上行脚太い部 / NKCC2 / ウロモジュリン / ヘンレ上行脚太い部ヘンレ上行脚太い部 / 髄質外層内帯 / 尿細管障害 / 多尿 / カルボキシペプチダーゼ / シアリダーゼ / beta-ガラクトシダーゼ / β-ガラクトシドーシス / モルキオβ病 / GM_1ガングリオシドーシス / 表現型 / β-ガライトシダーゼ / 制限酵素部位解析 / モルキオB病 / G_<M1>ガングリオシド-シス / ライソゾ-ム病 / βーガラクトシグ-ゼ Less

変異酵素の立体構造を化学的に操作できるシャペロン化合物の合理的設計と機能解析
- Principal Investigator
  
  加藤敦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Toyama
ファブリー病ではGb3からlyso-Gb3を生成する酸性セラミダーゼの発現の解析
- Principal Investigator
  
  丸山弘樹
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Niigata University
Design of functional chaperone compounds based on structural stabilisation of mutant enzymes and their application in the treatment of Pompe disease
- Principal Investigator
  
  Kato Atsushi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  University of Toyama
Analyses of essential interactions of iminosugars with the Hex A active site and evaluation of their pharmacological chaperone effects for Tay-Sachs disease
- Principal Investigator
  
  KATO Atsushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Toyama
Design and synthesis of iminosugar-based pharmacological chaperone as a structure stabilizing agent for mutation enzyme
- Principal Investigator
  
  Kato Atsushi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Toyama
Investigation of pathogenesis of Fabry nephropathy in novel model mouse
- Principal Investigator
  
  MARUYAMA Hiroki
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Niigata University
Design, synthesis, and biological evaluation of iminosugars as pharmacological chaperone for Gaucher disease
- Principal Investigator
  
  KATO Atsushi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Toyama
Preparation and application of mouse model for the study on chaperone therapy for Fabry diseasePrincipal Investigator
- Principal Investigator
  
  ISHII Satoshi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Covering analysis of glycogens in fowls and those related species and the establishment of molecularphy logenetic tree
- Principal Investigator
  
  KUSHI Yasunori
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
遺伝性ライソゾーム病における変異遺伝子発現機序の解析
- Principal Investigator
  
  鈴木義之
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
ヒトalpha-ガラクトシダーゼのシグナル配列除去におけるアミノ酸置換の影響Principal Investigator
- Principal Investigator
  
  石井達
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
遺伝性ライソゾーム病における変異遺伝子発現機序の解析
- Principal Investigator
  
  鈴木義之
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
遺伝性ライソゾ-ム病における変異遺伝子発現機序の解析
- Principal Investigator
  
  鈴木義之
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Gene expression and its application to the investigation on pathogenesis of congenital metabolic diseases and development of therapy for them.
- Principal Investigator
  
  SAKURABA Hitoshi
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Tokyo Metropolitan Institute of Medical Science

All 2013 2011 2010 2009 2005

All Journal Article Presentation Book

[Book] Fabry Disease, Chapter 29 : Pharmacological chaperone therapy for Fabry disease2010
- Author(s)
  Fan J.Q., Ishii S.
- Publisher
  Springer Science+Business Media
- Data Source
  KAKENHI-PROJECT-20590300
[Book] Pharmacological chaperone therapy for Fabry disease2010
- Author(s)
  Fan J.Q., Ishii S.
- Publisher
  Springer Science+Business Media、Fabry Disease Chapter
- Data Source
  KAKENHI-PROJECT-20590300
[Journal Article] A symptomatic Fabry disease mouse model generated by inducing globotriaosylceramide synthesis.2013
- Author(s)
  A. Taguchi, H. Maruyama, M. Nameta, T. Yamamoto, J. Matsuda, A B. Kulkaruni, H. Yoshioka and S. Ishii.
- Journal Title
  
  Biochem. J.
  
  Volume: 456 Issue: 3 Pages: 373-383
- DOI
  10.1042/bj20130825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390223
[Journal Article] Increased globotriaosylceramide levels in a transgenic mouse expressing human α 1,4-galactosyl-transferase and mouse model for Fabry disease2011
- Author(s)
  Shiozuka C., Mastuda J., Ishii S.
- Journal Title
  
  Journal of Biochemistry 149
  
  Pages: 161-170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590300
[Journal Article] Preclinical efficacy and safety of 1-deoxygalacto-nojirimycin in mice for Fabry disease2009
- Author(s)
  Ishii S., et al.
- Journal Title
  
  The journal of pharmacology and experimental therapeutics 328
  
  Pages: 723-731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590300
[Journal Article] Preclinical efficacy and safety of 1-deoxygalactonojirimycin in mice for Fabry disease2009
- Author(s)
  Ishii S, et.al.
- Journal Title
  
  The Journal of pharmacology and experimental therapeutics 328
  
  Pages: 723-731
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590300
[Presentation] Qunantitation analysis of globotriaosylceramide: Determination of its specificity and the application for human cells2005
- Author(s)
  Shin, I. Nishikawa, K., Kushi, Y., Ishii, S.
- Organizer
  第78回日本生化学会
- Place of Presentation
  神戸
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17405041
[Presentation] マウス由来細胞株におけるフォルスマン糖脂質の変化とその解析2005
- Author(s)
  新保はるか, レヌカカルナゴタ, 石井達, 野崎浩文, 櫛泰典
- Organizer
  第48回日本脂質生化学会
- Place of Presentation
  金沢
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17405041
[Presentation] Qunantitation analysis of globotriaosylceramide: Determination of its specificity and the application for human cells2005
- Author(s)
  Shin, I. Nishikawa, K., Kushi, Y., Ishii, S.
- Organizer
  The 78^<th> Annual meeting of Biochemistry
- Place of Presentation
  Kobe
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17405041

1. KATO Atsushi (60303236)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. ITOH Kohji (00184656)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. OSHIMA Akihiro (20203763)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. SAKURABA Hitoshi (60114493)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. ADACHI Isao (30151070)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. KASE Ryoichi (20150203)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. HIRONO Shuichi (30146328)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 鈴木義之 (90010389)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 名取良浩 (50584455)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. MARUYAMA Hiroki (10293218)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. 中込泉 (30237242)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. MATSUDA Junichiro (60181731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NISHIKAWA Yuji (90208166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NAKAZAWA Mikio (80143759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. MATSUYAMA Kiyoji (40209664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAKAHATA Hiroki (00109109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KUSHI Yasunori (60177988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
18. URASHIMA Tadasu (80185082)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. MIYOSHI Shunzo (50003132)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 大竹明 (00203810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 田口惇美 (80797069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. HARA Masanori

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Ishii Satoshi 石井 達

ISHII Satoshi 石井 達

石井 達 イシイ サトシ

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[Book] Fabry Disease, Chapter 29 : Pharmacological chaperone therapy for Fabry disease2010

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[Book] Pharmacological chaperone therapy for Fabry disease2010

Ishii Satoshi 石井達

ISHII Satoshi 石井達

石井達イシイサトシ