SUZUKI Yoshiyuki 鈴木義之

Researcher Number	90010389
External Links
Affiliation (based on the past Project Information) *help	2002 – 2004: 国際医療福祉大学, 保健学部, 教授 2001 – 2003: 国際医療福祉大学, 臨床医学研究センター, 教授 1997: (財)東京都臨床医学総合研究所, 副所長 1994 – 1997: 財団法人東京都臨床医学総合研究所, 副所長 1995: The Tokyo Metropolitan Institute of Medical Science, Vice-Director, 副所長 … More 1994 – 1995: 東京都臨床医学総合研究所, 副所長 1993: 財団法人東京都臨床医学総合研究所, 副所長 1991 – 1992: (財)東京都臨床医学総合研究所, 副所長 1991: 財団法人東京都臨床医学総合研究, 副所長 1988 – 1991: The Tokyo Metropolitan Institute of Medical Science, 副所長 1990: (財)東京都臨床医学総合研究所, 臨床遺伝学研究部門, 副所長 1986 – 1987: 国立精神, 神経センター(疾病研究第5部), 部長 1986: 国立精神, 神経センター・神経研究所, 部長 1986: 東大, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator Pediatrics / 応用薬理学・医療系薬学 / Pathological medical chemistry Except Principal Investigator Pediatrics / Laboratory medicine
Keywords	Principal Investigator lysosomal disease / 遺伝子変異 / G_<M1>-gangliosidosis / ライソゾーム病 / G_<M1>-ガングリオシドーシス / β-ガラクトシダーゼ / 線維芽細胞 / 優性遺伝病 / 二次元電気泳動 / 軟骨形成不全症 … More / fibroblast / hereditary dominant disease / two-dimensional electrophoresis / 二次元電気泳動法 / 高速液体クロマトグラフィー / N-octyl-4-epi-β-valianamine / genetically engineered mouse / competitive inhibitor / β-galactosidase / chemical chaperone therapy / GM1-ガングリオシドーシス / β-ガラクトシダーセ / N-オクチル-4-エピ-β-バリエナミン / 遺伝子組換えモデルマウス / 競合的阻害剤 / ケミカルシャペロン療法 / gene therapy / ganglioside G_<M1> / beta-galactosidase / knockout mouse / ガングリオシドGM1 / 遺伝子ターゲティング / ガングリオンドG_<M1> / 遺伝子治療 / ライリゾーム病 / ガングリオシドG_<M1> / ノックアウトマウス / phosphomannomutase / antithrombin / transferrin / beta-hexosaminidase / alpha-fucosidase / CDG syndrome / 先天性代謝異常 / 糖蛋白質 / オリゴ糖 / α-フコシダーゼ / ホスホマンノムターゼ / アンチトロンビン / β-ヘキソサミニダーゼ / トランスフェリン / α、フコシダーゼ / CDG症候群 / genotype-phenotype correlation / mutant protein / gene expression / two-dimensional gel electrophoresis / achondroplasia / マイコプラスマ感染 / ニ次元電気泳動 / 遺伝性ライゾ-ム病 / 遺伝子型表現型相関 / 遺伝性ライソゾ-ム病 / 変異蛋白質 / 遺伝子発現 / カルボキシペプチダーゼ / 保護蛋白質 / シアリダーゼ / beta-ガラクトシダーゼ / ガラクトシアリドーシス / β-ガラクトシドーシス / モルキオβ病 / GM_1ガングリオシドーシス / 表現型 / β-ガライトシダーゼ / 制限酵素部位解析 / モルキオB病 / G_<M1>ガングリオシド-シス / ライソゾ-ム病 / βーガラクトシグ-ゼ … More Except Principal Investigator 治療 / 糖転移酵素 / 発現制御 / 糖鎖遺伝子 / ガングリオシド / 診断 / 病因 / 糖鎖分解酵素 / lysosomal storage disease / treatment / chemical chaperon / G_<M1>-ガングリオドシドーシス / 先天代謝異常症 / 中枢神経障害 / GM1-ガングリオシドーシス / 先天代謝異常 / 低分子物質 / 中枢神経 / ケミカルシャペロン / Baculovirus expressed protein / substrates / Km / gene mutation / GM1 gangliosidosis / Morquio B disease / beta-galactosidase / Km値 / バキュロウィルス発現蛋白 / 基質認識 / 遺伝子変異 / GM1ガングリオシドーシス / モルキオB病 / β-ガラクトシダーゼ / 複合糖質代謝異常症 / ラジオイムノアッセイ / リソゾーム酵素 / マンノースリン酸レセプター / I-cell病 / 先天性複合糖質代謝異常症 / 糖糖分解酵素 Less

Development of a new molecular therapeutic drug for brain pathology in lysosomal storage diseasesPrincipal Investigator
- Principal Investigator
  
  SUZUKI Yoshiyuki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  International University of Health and Welfare
A study of the new therapeutic method and the clinical application for central nervous involvement in inherited metabolic diseases.
- Principal Investigator
  
  NANBA Eiji
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tottori University
Pathogenesis and Treatment of beta-Galactosidase-Deficient Knockout MicePrincipal Investigator
- Principal Investigator
  
  SUZUKI Yoshiyuki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The Tokyo Metropolitan Institute of Medical Science
Etiology and Pathogenesis of CDG SyndromePrincipal Investigator
- Principal Investigator
  
  SUZUKI Yoshiyuki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  The Tokyo Metropolitan Institute of Medical Science
Altered substrate recognition of mutant enzymes which catalyzes hydrolysis of oligosuccharide chain, and related with clinical phenotype and straged substrates.
- Principal Investigator
  
  FUKUHARA Yukiko
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  The Tokyo Metropolitan Institute of Medical Science
遺伝性ライソゾーム病における変異遺伝子発現機序の解析Principal Investigator
- Principal Investigator
  
  鈴木義之
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
遺伝性ライソゾーム病における変異遺伝子発現機序の解析Principal Investigator
- Principal Investigator
  
  鈴木義之
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
ガングリオシド糖鎖遺伝子と発現制御
- Principal Investigator
  
  鈴木明身
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
遺伝性ライソゾ-ム病における変異遺伝子発現機序の解析Principal Investigator
- Principal Investigator
  
  鈴木義之
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
ガングリオシド糖鎖遺伝子と発現制御
- Principal Investigator
  
  鈴木明身
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
ガングリオシド糖鎖遺伝子と発現制御
- Principal Investigator
  
  鈴木明身
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Melecular genetic study in the pathogenesis of achondroplasiaPrincipal Investigator
- Principal Investigator
  
  SUZUKI Yoshiyuki
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  The Tokyo Metropolitan Institute of Medical Science
先天性複合糖質代謝異常症の病因・診断および治療に関する研究
- Principal Investigator
  
  折居忠夫
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Gifu University
先天性複合糖質代謝異常症の病因・診断および治療に関する研究
- Principal Investigator
  
  折居忠夫
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Gifu University
I-cell病におけるリソゾーム酵素レセプターの研究
- Principal Investigator
  
  宮下俊之
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokyo
Development of a screening system for the pathogenesis of hereditary dominant diseasesPrincipal Investigator
- Principal Investigator
  
  SUZUKI Yoshiyuki
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Pediatrics
- Research Institution
  The Tokyo Metropolitan Institute of Medical Science
  National Center of Neurology and Psychiatry
  The University of Tokyo

All 2005 2004 2003 2002

All Journal Article Book Patent

[Book] Metabolic and Molecular Bases of Inherited Disease, 8th ed, <http://genetics.accessmedicine.com/>2004
- Author(s)
  Suzuki Y, Oshima A, Nanba E
- Publisher
  McGraw-Hill, New York (Online version)
- Data Source
  KAKENHI-PROJECT-14207106
[Book] The Metabolic and Molecular Bases of Inherited Disease, 8th ed,<http://genetics.accessmedicine.com/>(Scriver CR, Beaudet AL, Sly WS, Valle D, Childs B, Vogelstein B (eds))2004
- Author(s)
  Suzuki Y, Oshima A, Nanba E
- Publisher
  McGraw-Hill, New York(Online version)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207106
[Journal Article] ライソゾーム病に対するケミカルシャペロン療法2005
- Author(s)
  鈴木義之
- Journal Title
  
  小児科 45
  
  Pages: 2313-2320
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207106
[Journal Article] N-Octyl-β-valienamine up-regulates activity of F213I mutant β-glucosidase in cultured cells : a potential chemical chaperone therapy for Gaucher disease2004
- Author(s)
  Lin H, Sugimoto Y, Ohsaki Y, Ninomiya H, Oka A, Taniguchi M, Ida H, Eto Y, Ogawa S, Matsuzaki Y, Sawa M, Inoue T, Higaki K, Nanba E, Ohno K, Suzuki Y
- Journal Title
  
  Biochim Biophys Acta 1689
  
  Pages: 219-228
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207106
[Journal Article] υ^^--Galactosidase deficiency (υ^^--galactosidosis) : G_<M1>-Gangliosidosis and Morquio B disease2004
- Author(s)
  Suzuki Y, Oshima A, Nanba E
- Journal Title
  
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed, <http://genetics.accessmedicine.com/>(Scriver CR, Beaudet AL, Sly WS, Valle D, Childs B, Vogelstein B (eds))(McGraw-Hill, New York)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207106
[Journal Article] Skeletal muscle FOXO1 (FKHR)-transgenic mice have less skeletal muscle mass, down-regulated type I (slow twitch/red muscle) fiber genes, and impaired glycemic control2004
- Author(s)
  Kamei Y, Miura S, Suzuki M, Kai Y, Mizukami J, Taniguchi T, Mochida K, Hata T, Matsuda J, Aburatani H, Nishino I, Ezaki O
- Journal Title
  
  J Biol Chem 279
  
  Pages: 41114-41123
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207106
[Journal Article] Chromosomal mapping and zygosity check of transgenes based on flanking genome sequences determined by genomic walking.2004
- Author(s)
  Noguchi A, Takekawa N, Einarsdottir T, Koura M, Noguchi Y, Takano K, Yamamoto Y, Matsuda J, Suzuki O
- Journal Title
  
  Exp Anim 53
  
  Pages: 103-111
- NAID
  10012888948
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207106
[Journal Article] Chromosomal mapping and zygosity check of transgene based on flanking genome sequences determined by genomic walking2004
- Author(s)
  Noguchi A, Takekawa N, Einarsdottir T, Koura M, Noguchi Y, Takano K, Yamamoto Y, Matsuda J, Suzuki O
- Journal Title
  
  Exp Anim 53
  
  Pages: 103-111
- NAID
  10012888948
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207106
[Journal Article] Sequence analysis of cDNA encoding follicle-stimulating hormone and luteinizing hormone b subunits in the Mastomys (Praomys coucha).2004
- Author(s)
  Takano K, Koura M, Noguchi Y, Yamamoto Y, Uchio-Yamada K, Matsuda J, Suzuki O
- Journal Title
  
  Gen Comp Endocr 138
  
  Pages: 281-286
- Data Source
  KAKENHI-PROJECT-14207106
[Journal Article] N-Octyl-β-valienamine up-regulates activity of F213I mutant β-glucosidase in cultured cells : a potential chemical chaperone therapy for Gaucher disease2004
- Author(s)
  Lin H, Sugimoto Y, Ohsaki Y, Ninomiya H, Oka A, Taniguchi M, Ida H, Eto Y, Ogawa S, Matsuzaki Y, Sawa M, Inoue T, Higaki K, Nanba E, Ohno K, Suzuki Y
- Journal Title
  
  Biochem Biophys Acta 1689
  
  Pages: 219-228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207106
[Journal Article] Chemical chaperone therapy for brain pathology in G_<M1>-gangliosidosis2003
- Author(s)
  Matsuda J, Suzuki O, Oshima A, Yamamoto Y, Noguchi A, Takimoto K, Itoh M, Matsuzaki Y, Yasuda Y, Ogawa S, Sakata Y, Nanba E, Higaki K, Ogawa Y, Tominaga L, Ohno K, Iwasaki H, Watanabe H, Brady RO, Suzuki Y
- Journal Title
  
  Proc Natl Acad Sci USA 100
  
  Pages: 15912-15917
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207106
[Journal Article] Attenuation of ganglioside G_<M1> accumulation in the brain of G_<M1> gangliosidosis mice by neonatal intravenous gene transfer2003
- Author(s)
  Takaura N, Yagi T, Maeda M, Nanba E, Oshima A, Suzuki Y, Yamano T, Tanaka A
- Journal Title
  
  Gene Ther 10
  
  Pages: 1487-1493
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207106
[Journal Article] Chemical chaperone therapy for brain pathology in G_<M1>-gangliosidosis2003
- Author(s)
  Matsuda J, Suzuki O, Oshima A, Yamamoto Y, Noguchi A, Takimoto K, Itoh M, Matsuzaki Y, Yasuda Y, Ogawa S, Sakata Y, Nanba E, Higaki K, Ogawa Y, Tominaga L, Ohno K, Iwasaki H, Watanabe H Brady RO, Suzuki Y
- Journal Title
  
  Proc Natl Acad Sci USA 100
  
  Pages: 15912-15917
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14207106
[Journal Article] Chemical modification of the β-glucocerebrosidase inhibitor N-octyl-β-valienamine : Synthesis and biological evaluation of 4-epimeric and 4-O-(β-D-galactopyranosyl) derivatives2002
- Author(s)
  Ogawa S, Matsunaga YK, Suzuki Y
- Journal Title
  
  Bioorg Med Chem 10
  
  Pages: 1967-1972
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207106
[Patent] Carba-sugar amine derivatives and treatments for disorder of glycolipid metabolism containing the same as the active ingredient2002
- Inventor(s)
  小川誠一郎, 鈴木義之, 難波栄二, 松田潤一郎, 大野耕策
- Industrial Property Rights Holder
  生化学工業株式会社
- Filing Date
  2002-09-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207106
[Patent] 糖脂質代謝異常症治療剤2002
- Inventor(s)
  鈴木義之, 難波栄二, 松田潤一郎
- Industrial Property Rights Holder
  生化学工業株式会社
- Industrial Property Number
  2002-260534
- Filing Date
  2002-09-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14207106

1. SAKURABA Hitoshi (60114493)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. OSHIMA Akihiro (20203763)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. ITOH Kohji (00184656)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. 鈴木明身 (70134533)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. 別府輝彦 (80011873)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 村松喬 (00030891)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 成松久 (40129581)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 牧田章 (60004561)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. 石井達 (00222935)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. 加瀬良一 (20150203)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. SAKAKIHARA Yoich (10143463)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. OHNO Kousaku (70112109)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
13. MATSUDA Junichiro (60181731)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
14. NANBA Eiji (40237631)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
15. 折居忠夫 (20045339)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 一色玄 (80046995)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. 南良二 (00045428)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
18. 山科郁男 (70025675)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
19. 木幡陽 (30030852)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. 宮下俊之 (60174182)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
21. YAMANAKA Tatsuhiro (00143462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. NAGAO Yoshiro (60211439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. FUKUHARA Yukiko (10124489)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. FAN Jian-Qiang (30291157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. NAIKI Masaharu (10020752)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. MAEGAWA Shinji (70314606)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. KUROSAWA Mieko (30178131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 大竹明 (00203810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 山本俊至 (20252851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 床枝康伸 (10172157)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 大村清 (70047348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. IIDA Masami

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 松崎祐二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SUZUKI Yoshiyuki 鈴木 義之

Research Projects

Research Products

Co-Researchers

Development of a new molecular therapeutic drug for brain pathology in lysosomal storage diseasesPrincipal Investigator

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Pathogenesis and Treatment of beta-Galactosidase-Deficient Knockout MicePrincipal Investigator

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Etiology and Pathogenesis of CDG SyndromePrincipal Investigator

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遺伝性ライソゾーム病における変異遺伝子発現機序の解析Principal Investigator

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遺伝性ライソゾーム病における変異遺伝子発現機序の解析Principal Investigator

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遺伝性ライソゾ-ム病における変異遺伝子発現機序の解析Principal Investigator

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Melecular genetic study in the pathogenesis of achondroplasiaPrincipal Investigator

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Development of a screening system for the pathogenesis of hereditary dominant diseasesPrincipal Investigator

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SUZUKI Yoshiyuki 鈴木義之