Maru Yoshiro 丸義朗

… Alternative Names

maru yoshiro 丸義朗

MARU Yoshiro 丸義朗

丸義朗マルヨシロウ

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Researcher Number	00251447
Other IDs
Affiliation (Current)	2025: 早稲田大学, 次世代ロボット研究機構, 客員上級研究員(研究院客員教授)
Affiliation (based on the past Project Information) *help	2019 – 2022: 東京女子医科大学, 医学部, 教授 2016: 東京女子医科大学, 医学部, 教授 2008 – 2014: Tokyo Women's Medical University, 医学部, 教授 2003 – 2004: 東京女子医科大学, 医学部, 教授 2002: 東京女子医科大学, 医学部・(薬理学), 教授 1996 – 2001: 東京大学, 医科学研究所, 助教授 1993 – 1995: 東京大学, 医科学研究所, 助手
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 50010:Tumor biology-related / Biological Sciences Except Principal Investigator Tumor therapeutics / Tumor biology / Hematology / Biological Sciences / Biological Sciences
Keywords	Principal Investigator TLR4 / S100A8 / ケモカイン / 増殖因子 / 転移 / 血液凝固 / 血管透過性 / 転移前微小環境 / 癌 / がん … More / TLR / 内因性リガンド / 炎症 / ADAM12 / CCR2 / がん転移 / 自然免疫 / ephrinA1 / CCL2 / SAA3 / ケモカン / 癌抑制遺伝子 / カタニン / 細胞骨格 / 細胞運動 / 微小管 / TFIIH / XPB / DNA修復 / BCR-ABL / 癌遺伝子 / 慢性骨髄性白血病 / 2原子分子 / HBP23 / メタロプロテアーゼ / PKC / THIIH / 癌細胞 / ABL / Flt-1 / VEGF / CD2AP / Nox1 / 金属蛋白 / エンドサイトーシス / HSC70 / PAI-1 / 活性酵素 / 血管 / 金属 / 卵細胞 / 血管内皮細胞 / Nox / チロシンキナーゼ / 活性酸素 … More Except Principal Investigator 腫瘍血管 / シグナル伝達 / アポトーシス / VEGF / 血管透過性 / キサントフモール / 破骨細胞形成抑制 / がん細胞増殖抑制 / 骨転移 / 肺転移 / 骨破壊 / 破骨細胞 / カスパーゼ-3 / 抗腫瘍活性 / プレニル化フラボノイド / 転移 / IL-8転写 / ヌクレオソーム / C1D / タンパク質分解 / 増殖抑制 / HOXA9 / HDAC阻害剤 / CXCR4 / インテグリン / 国際情報交換 / カルシニューリン / 接着分子 / 多発性骨髄腫 / 血液腫瘍学 / セルソーター / アウトリーチ活動 / 遺伝子改変マウス / 病原体センサー / 炎症 / Toll様受容体 / 自然免疫 / VEGF-E / トランスジェニックマウス / 系統発生 / VEGFR-1(Flt-1) / VEGFR-2(KDR) / VEGFR-1 (Flt-1) / VEGFR-2 (KDR) / がん転移 / VEGFR-1 / VEGFR-2 / 血管新生 / ノックインマウス / VEGF受容体 / EGFR / Flt / 受容体型チロシンキナーゼ / がん関連遺伝子 / KDR / C-キナーゼ / チロシンキナーゼ / 腫瘍プロモーター / 内及細胞増殖因子 / PLCr / GAP / 内皮細胞増殖因子 / Flt受容体 / Shc / EGF受容体 Less

Novel immunothrombosis on premetastatic niche formationPrincipal Investigator
- Principal Investigator
  
  maru yoshiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Women's Medical University
Suppression of cancer metastases by hop-derived prenylflavonoids and drug discovery research
- Principal Investigator
  
  Morichika Takita
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokyo Women's Medical University
Role of C1D in metastasis of cancer and drug discovery research
- Principal Investigator
  
  TAKITA Morichika
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Women's Medical University
Molecular mechanism of refractoriness of myeloma mediated by adhesion molecules
- Principal Investigator
  
  IMAI Yoichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Women's Medical University
Homeostatic inflammation: Molecular basis and dysregulation
- Principal Investigator
  
  MIYAKE Kensuke
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Endogenous TLR4 ligands in tumor metastasis.Principal Investigator
- Principal Investigator
  
  MARU Yoshiro
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Women's Medical University
3つの新しい運動制御系の解析Principal Investigator
- Principal Investigator
  
  丸義朗
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Women's Medical University
酸化ストレスを伴う哺乳類細胞の生物学的系における抗酸化分子とチロシンキナーゼPrincipal Investigator
- Principal Investigator
  
  丸義朗
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Women's Medical University
  The University of Tokyo
BCR-ABLのDNA修復機構における分子生物学的意義の解析Principal Investigator
- Principal Investigator
  
  丸義朗
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
腫瘍の形成と維持の機構
- Principal Investigator
  
  渋谷正史
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
がん遺伝子の単離とヒトがんにおける異常の解明
- Principal Investigator
  
  渋谷正史
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
がん遺伝子産物の作用機構と増殖シグナルの異常伝達
- Principal Investigator
  
  渋谷正史
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo

[Book] Inflammation and metastasis (2nd edition).2021
- Author(s)
  Maru Y.
- Total Pages
  538
- Publisher
  Springer
- ISBN
  9789811617560
- Data Source
  KAKENHI-PROJECT-19H03506
[Book] 医学のあゆみ 258巻1号がんの臓器特異的転移を決定する転移ニッチ2016
- Author(s)
  瀧田守親、丸義朗
- Total Pages
  10
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-15K14411
[Book] 細胞工学2014
- Author(s)
  富田毅、丸義朗
- Publisher
  株式会社　学研メディカル秀潤社
- Data Source
  KAKENHI-PLANNED-21117008
[Book] 医学のあゆみ2014
- Author(s)
  塚原富士子、丸義朗
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PLANNED-21117008
[Book] がん転移先微小環境を「見直す」2012
- Author(s)
  丸義朗
- Publisher
  ニューサイエンス社,東京,日本
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Variant spectrum of PIEZO1 and KCNN4 in Japanese patients with dehydrated hereditary stomatocytosis.2023
- Author(s)
  Nakahara E, Shimojima Yamamoto K, Ogura H, Aoki T , Utsugisawa T, Azuma K, Akagawa H, Watanabe K, Muraoka M, Nakamura F, Kamei M, Tatebayashi K, Shinozuka J, Yamane T, Hibino M, Katsura Y, Nakano-Akamatsu S, Kadowaki N, Maru Y, Etsuro Ito E, Ohga S, Yagasaki H, Morioka I, Yamamoto T and Kanno H.
- Journal Title
  
  Hum Genome Var
  
  Volume: 10 Issue: 1 Pages: 8-8
- DOI
  10.1038/s41439-023-00235-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03506, KAKENHI-PROJECT-20K08239, KAKENHI-PROJECT-23K21429, KAKENHI-PROJECT-21K07873
[Journal Article] Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway2023
- Author(s)
  Deguchi A, Watanabe-Takahashi M, Mishima T, Omori T, Ohto U, Arashiki N, Nakamura F, Nishikawa K, Maru Y.
- Journal Title
  
  Cancer Gene Ther
  
  Volume: - Issue: 7 Pages: 1-12
- DOI
  10.1038/s41417-023-00604-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07157, KAKENHI-PROJECT-19H03506, KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-23K23820
[Journal Article] Inflammation and premetastasis niche formation.2022
- Author(s)
  Deguchi A, Maru Y.
- Journal Title
  
  Inflamm Regen
  
  Volume: 42 Issue: 1 Pages: 22-22
- DOI
  10.1186/s41232-022-00208-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07157, KAKENHI-PROJECT-19H03506
[Journal Article] The Sympathetic Nervous System Contributes to the Establishment of Pre-Metastatic Pulmonary Microenvironments.2022
- Author(s)
  Ieguchi K, Funakoshi M, Mishima T, Takizawa K, Omori T, Nakamura F, Watanabe M, Tsuji M, Kiuchi Y, Kobayashi S, Tsunoda T, Maru Y, Wada S.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 23 Issue: 18 Pages: 10652-10652
- DOI
  10.3390/ijms231810652
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03506
[Journal Article] Extracellular mRNA transported to the nucleus exerts translation-independent function2021
- Author(s)
  Tomita Takeshi、Kato Masayoshi、Mishima Taishi、Matsunaga Yuta、Sanjo Hideki、Ito Ken-ichi、Minagawa Kentaro、Matsui Toshimitsu、Oikawa Hiroyuki、Takahashi Satoshi、Takao Toshifumi、Iwai Noriki、Mino Takashi、Takeuchi Osamu、Maru Yoshiro、Hiratsuka Sachie
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 3655-3655
- DOI
  10.1038/s41467-021-23969-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06577, KAKENHI-PROJECT-18H05278, KAKENHI-PROJECT-19H03488, KAKENHI-PROJECT-19H03500, KAKENHI-PROJECT-20K06554, KAKENHI-PROJECT-21K06868, KAKENHI-PROJECT-19H03506, KAKENHI-PROJECT-21H02438
[Journal Article] S100A8 may govern hyper-inflammation in severe COVID-19.2021
- Author(s)
  Deguchi A, Yamamoto T, Shibata N, Maru Y.
- Journal Title
  
  FASEB J.
  
  Volume: 35 Issue: 9
- DOI
  10.1096/fj.202101013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07157, KAKENHI-PROJECT-19H03506, KAKENHI-PROJECT-18K07245
[Journal Article] Analysis of ADAM12-Mediated Ephrin-A1 Cleavage and Its Biological Functions2021
- Author(s)
  Ieguchi Katsuaki、Tomita Takeshi、Takao Toshifumi、Omori Tsutomu、Mishima Taishi、Shimizu Isao、Tognolini Massimiliano、Lodola Alessio、Tsunoda Takuya、Kobayashi Shinichi、Wada Satoshi、Maru Yoshiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 5 Pages: 2480-2480
- DOI
  10.3390/ijms22052480
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03506
[Journal Article] Premetastasis2019
- Author(s)
  Yoshiro Maru
- Journal Title
  
  Cold Spring Harb Perspect Med
  
  Volume: a036897 Issue: 11 Pages: a036897-a036897
- DOI
  10.1101/cshperspect.a036897
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03506
[Journal Article] ADAM12-cleaved ephrin-A1 contributes to lung metastasis2014
- Author(s)
  Ieguchi K, Tomita T, Omori T, Komatsu A, Deguchi A, Masuda J, Duffy S, Coulthard M, Boyd A, Maru Y
- Journal Title
  
  Oncogene
  
  Volume: 33(17) Pages: 2179-2190
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 42013
- Author(s)
  Ieguchi K, Omori T, Komatsu A, Tomita T, Deguchi A, Maru Y
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 440(4) Pages: 623-629
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Identification of calcineurin as a novel therapeutic target in multiple myeloma2013
- Author(s)
  Imai Y, Ohta E, Wang Y, Kitagawa Y, Ding Y, Yamada O, Maru Y, Motoji T
- Journal Title
  
  Clinical Lymphoma, Myeloma, & Leukemia
  
  Volume: 13
- Data Source
  KAKENHI-PROJECT-23591409
[Journal Article] Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci2013
- Author(s)
  Hiratsuka S, Ishibashi S, Tomita T, Watanabe A, Tamura SA, Murakami M, Kijima H, Miyake K, Aburatani H, Maru Y
- Journal Title
  
  Nat Commun
  
  Volume: 4 Issue: 1 Pages: 1853-1853
- DOI
  10.1038/ncomms2856
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008, KAKENHI-PROJECT-23590386, KAKENHI-PROJECT-23590564, KAKENHI-PROJECT-24221011
[Journal Article] Identification of calcineurin as a novel therapeutic target in multiple myeloma.2013
- Author(s)
  Imai Y, Ohta E, Wang Y, Kitagawa Y, Ding Y, Yamada O, Maru Y, Motoji T
- Journal Title
  
  Clinical Lymphoma, Myeloma, & Leukemia
  
  Volume: 13 supplement 1 Pages: 47-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591409
[Journal Article] Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 42013
- Author(s)
  Ieguchi K, Omori T, Komatsu A, Tomita T, Deguchi A, Maru Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 440(4) Issue: 4 Pages: 623-629
- DOI
  10.1016/j.bbrc.2013.09.119
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008, KAKENHI-PROJECT-23590347, KAKENHI-PROJECT-24501321, KAKENHI-PUBLICLY-25122716, KAKENHI-PROJECT-25870760
[Journal Article] Serum Amyroid A3 binds MD-2 to activates p38 and NF-kB pathway in a MyD88-dependent manner2013
- Author(s)
  Deguchi A, Tomita T, Omori T, Komatsu A, Ohto U, Takahashi S, Tanimura N, Akashi-Takamura S, Miyake K, Maru Y
- Journal Title
  
  J Immunol
  
  Volume: 191(4) Issue: 4 Pages: 1856-1864
- DOI
  10.4049/jimmunol.1201996
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008, KAKENHI-PROJECT-23590347, KAKENHI-PROJECT-23590564, KAKENHI-PROJECT-24501321, KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25650029
[Journal Article] Connexin43 Functions as a Novel Interacting Partner of Heat Shock Cognate Protein 702013
- Author(s)
  Hatakeyama T, Dai P, Harada Y, Hino H, Tsukahara F,Maru Y, Otsuji E, Takamatsu T
- Journal Title
  
  Sci Rep.
  
  Volume: 3 Pages: 2179-2179
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Connexin43 Functions as a Novel Interacting Partner of Heat Shock Cognate Protein 702013
- Author(s)
  Hatakeyama T, Dai P, Harada Y, Hino H, Tsukahara F, Maru Y, Otsuji E, Takamatsu T
- Journal Title
  
  Sci Rep
  
  Volume: 3 Issue: 1 Pages: 2719-2719
- DOI
  10.1038/srep02719
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008, KAKENHI-PROJECT-23590309
[Journal Article] Serum Amyroid A3 binds MD-2 to activates p38 and NF-kB pathway in a MyD88-dependent manner2013
- Author(s)
  Deguchi A, Tomita T, Omori T, Komatsu A, Ohto U, Takahashi S, Tanimura N, Akashi-Takamura S, Miyake K, Maru Y
- Journal Title
  
  J Immunol. 2013
  
  Volume: 191, 4, 2013 Pages: 1856-1864
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Primary tumours modulate innate immune signalling to create pre-metastatic vascular hyperpermeability foci2013
- Author(s)
  Hiratsuka S, Ishibashi S, Tomita T, Watanabe A, Tamura S, Murakami M, Kijima H, Miyake K, Aburatani H, Maru Y
- Journal Title
  
  Nat Commun
  
  Volume: 4 Pages: 1853-1853
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] MLL-HOXA9 and calcineurin are novel therapeutic targets in multiple myeloma2012
- Author(s)
  Imai Y, Ohta E, Wang Y, Kitagawa Y, Ding Y, Yamada O, Maru Y, Motoji T
- Journal Title
  
  American Society of Hematology annual meeting abstracts
  
  Volume: 120 Pages: 4007-4007
- Data Source
  KAKENHI-PROJECT-23591409
[Journal Article] Molecular biology of chronic myeloid leukemia.2012
- Author(s)
  Maru Yoshiro
- Journal Title
  
  Cancer science
  
  Volume: 103 Issue: 9 Pages: 1601-1610
- DOI
  10.1111/j.1349-7006.2012.02346.x
- NAID
  10007320374
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Molecular biology of chronic myeloid leukemia2012
- Author(s)
  Maru Y
- Journal Title
  
  Cancer Sci.
  
  Volume: 103, 9 Pages: 1601-1610
- NAID
  10007320374
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] FOXA1 plays a role in regulating secretoglobin 1a1 expression in the absence of CCAAT/enhancer binding protein activities in lung in vivo2011
- Author(s)
  Kido T, Tomita T, Okamoto M, Cai Y, Matsumoto Y, Vinson C, Maru Y, Kimura S
- Journal Title
  
  American Journal of Physiology-Lung Cellular and Molecular Physiology
  
  Volume: 300 Issue: 3 Pages: L441-L452
- DOI
  10.1152/ajplung.00435.2009
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Endogenous ligand-induced activation of TLR4 in Pre-metastatic phase is both downstream and upstream of TNF signaling2011
- Author(s)
  Maru Y
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: 691 Pages: 261-268
- DOI
  10.1007/978-1-4419-6612-4_26
- ISBN
  9781441966117, 9781441966124
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis2011
- Author(s)
  Tomita T, Sakurai Y, Ishibashi S, Maru Y
- Journal Title
  
  Oncogene
  
  Volume: 30 Issue: 31 Pages: 3429-3439
- DOI
  10.1038/onc.2011.53
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis2011
- Author(s)
  Tomita T, Sakurai Y, Ishibashi S, Maru Y
- Journal Title
  
  Oncogene.
  
  Volume: 30 Pages: 3429-3439
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Endogenous ligand-induced activation of TLR4 in Pre-metastatic phase is both downstream and upstream of TNF signaling2011
- Author(s)
  Maru Y
- Journal Title
  
  Adv Exp Med Biol.
  
  Volume: 691 Pages: 261-268
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation2011
- Author(s)
  Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK
- Journal Title
  
  PNAS (Proceedings of the National Academy of Sciences of the United States of America)
  
  Volume: 103 Issue: 9 Pages: 3725-3730
- DOI
  10.1073/pnas.1100446108
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation2011
- Author(s)
  Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK
- Journal Title
  
  Proc Natl Acad Sci USA.
  
  Volume: 108 Pages: 3725-3730
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis.2011
- Author(s)
  Tomita T, Sakurai Y, Ishibashi S, Maru Y.
- Journal Title
  
  Oncogene
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc702011
- Author(s)
  Zou P, Yoshihara H, Hosokawa K, Tai I, Shinmyozu K, Tsukahara F, Maru Y, Nakayama K, Nakayama KI, Suda T
- Journal Title
  
  Cell Stem Cell
  
  Volume: 9 Pages: 247-261
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Bag1 directly routes immature BCR-ABL for proteasomal degradation.2010
- Author(s)
  Tsukahara F, Maru Y.
- Journal Title
  
  Blood
  
  Volume: 116 Pages: 3582-3592
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] XPB induces C1D expression to counteract UV-induced apoptosis.2010
- Author(s)
  Li G, Liu J, Abu-Asab M, Masabumi S, Maru Y.
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 8 Pages: 885-895
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Bag1 directly routes immature BCR-ABL for proteasomal degradation2010
- Author(s)
  Tsukahara F, Maru Y
- Journal Title
  
  Blood.
  
  Volume: 116 Pages: 3582-3592
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] XPB induces C1D expression to counteract UV-induced apoptosis2010
- Author(s)
  Li G, Liu J, Abu-Asab M, Shibuya M, Maru Y
- Journal Title
  
  Mol Cancer Res.
  
  Volume: 8 Pages: 885-895
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Pre-metastatic milieu explained by TLR4 agonist-mediated homeostatic inflammation2010
- Author(s)
  Maru Y
- Journal Title
  
  Cell and Mol Immun.
  
  Volume: 7 Pages: 94-99
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Logical structures extracted from metastasis experiments2009
- Author(s)
  Maru Y
- Journal Title
  
  Cancer Sci.
  
  Volume: 100 Pages: 2006-2013
- NAID
  10027196385
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] A concept of homeostatic inflammation provided by endogenous TLR4 a gonists that function before and after danger signal for metastasis.2009
- Author(s)
  Yoshiro Maru
- Journal Title
  
  Anti-Inflamm. & Anti-Allerg Agents in Medicinal Chemistry 8
  
  Pages: 337-347
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] The tumor suppressor LZTS2 functions through the cellular samurai Katanin2009
- Author(s)
  Maru Y
- Journal Title
  
  Cent Eur J Biol.
  
  Volume: 4 Pages: 1-10
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility2009
- Author(s)
  Yamazaki T, Masuda J, Omori T, Usui R, Akiyama H, Maru Y
- Journal Title
  
  J Cell Sci.
  
  Volume: 122 Pages: 243-255
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Logical structures extracted from metastatic experiments.2009
- Author(s)
  Yoshiro Maru
- Journal Title
  
  Cancer Science 100
  
  Pages: 2006-2013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] A Concept of Homeostatic Inflammation Provided by Endogenous TLR4 Agonists that Function Before and After Danger Signal for Metastasis2009
- Author(s)
  Maru Y
- Journal Title
  
  Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
  
  Volume: 8 Pages: 337-347
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Membrane-fixation of VEGFR1 ligand-binding domain is important for vasculogenesis/angiogenesis in mice.2005
- Author(s)
  Hiratsuka, S., Nakao, K., Nakamura, K., Katsuki, M., Maru, Y., Shibuya, M.
- Journal Title
  
  Mol.Cell.Biol. 25
  
  Pages: 346-354
- Data Source
  KAKENHI-PROJECT-12215024
[Journal Article] The c-Cb1/CD2AP complex regulates VEGF-induced endocytosis and degradation of Flt-1 (VEGFR-1).2004
- Author(s)
  Kobayashi, S., Sawano, A., Nojima, Y., Shibuya, M., Maru, Y.
- Journal Title
  
  FASEB J. 18
  
  Pages: 929-931
- Data Source
  KAKENHI-PROJECT-12215024
[Journal Article] Expression of Nox genes in rat organs, mouse oocytes, and sea urchin eggs
- Author(s)
  Maru et al.
- Journal Title
  
  DNA Sequences (印刷中)
- Data Source
  KAKENHI-PROJECT-12147202
[Patent] S100A8-INHIBITING PEPTIDE AND DISEASE THERAPEUTIC AGENT CONTAINING SAME2022
- Inventor(s)
  丸義朗、出口敦子、髙橋美帆、西川喜代孝、大戸梅治
- Industrial Property Rights Holder
  学校法人東京女子医科大学、学校法人同志社
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03506
[Patent] S100A8阻害ペプチドとこれを含む疾患治療薬2021
- Inventor(s)
  丸義朗、出口敦子、髙橋美帆、西川喜代孝、大戸梅治
- Industrial Property Rights Holder
  学校法人東京女子医科大学、学校法人同志社
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-19H03506
[Patent] S100A8阻害ペプチドとこれを含む疾患治療薬2020
- Inventor(s)
  丸義朗、出口敦子、髙橋美帆、西川喜代孝、大戸梅治
- Industrial Property Rights Holder
  東京女子医科大学、同志社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-096367
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-19H03506
[Patent] p210 PH結合ペプチドおよび慢性骨髄性白血病治療薬2019
- Inventor(s)
  西川喜代孝、島崎健太朗、長田雅也、丸義朗、塚原富士子他
- Industrial Property Rights Holder
  学校法人同志社、学校法人東京女子医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19H03506
[Presentation] S100A8を標的とした新規がん微小環境改善薬の開発2022
- Author(s)
  出口敦子、西川喜代孝、丸義朗
- Organizer
  日本医療研究開発機構革新的医療技術創出拠点令和3年度成果報告会
- Data Source
  KAKENHI-PROJECT-19H03506
[Presentation] 転移前微小環境形成による転移促進2021
- Author(s)
  丸義朗、出口敦子
- Organizer
  第80回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H03506
[Presentation] 喫煙による転移前微小環境形成の促進と血清アミロイドA3の意義2021
- Author(s)
  出口敦子、丸義朗
- Organizer
  喫煙科学研究財団第35回令和2年度助成研究発表会
- Data Source
  KAKENHI-PROJECT-19H03506
[Presentation] Identification of PPP3CA, catalytic subunit of Calcineurin as a target of multiple myeloma therapy.2013
- Author(s)
  今井陽一, 太田瑛里, 王艶華, テインイエ, 丸義朗, 泉二登志子
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  札幌、日本
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] Identification of Calcineurin as a Novel Therapeutic Target in Multiple Myeloma2013
- Author(s)
  Yoichi Imai, Eri Ohta, Yanhua Wang, Yukiko Kitagawa, Ye Ding, Osamu Yamda, Yoshiro Maru, and Toshiko Motoji
- Organizer
  14th International Myeloma　Ｗｏｒｋｓｈｏｐ
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591409
[Presentation] How premetastatic milieu is established2013
- Author(s)
  Maru Yoshiro
- Organizer
  6th international Singapore Symposium of Immunology
- Place of Presentation
  Singapore
- Invited
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] Identification of calcineurin as a novel therapeutic target in multiple myeloma2013
- Author(s)
  Imai Y, Ohta E, Wang Y, Kitagawa Y, Ding Y, Yamada O, Maru Y, Motoji T
- Organizer
  14th International Myeloma Workshop
- Place of Presentation
  Kyoto
- Year and Date
  2013-04-04
- Data Source
  KAKENHI-PROJECT-23591409
[Presentation] Identification of calcineurin as a novel therapeutic target in multiple myeloma.2013
- Author(s)
  IMAI Yoichi, OHTA Eri, WANG Yanhua, KITAGAWA Yukiko, DING Ye, YAMADA Osamu, MARU Yoshiro, MOTOJI Toshiko
- Organizer
  14th International Myeloma Workshop
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] The endogenous TLR4 ligand-mediated vaso-permeability is required for lung metastasis2013
- Author(s)
  Maru Yoshiro
- Organizer
  10th International Conference on Innate Immunity
- Place of Presentation
  Kos, Greece
- Invited
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] ADAM12-cleaved ephrin-A1 contributes to lung metastasis.2013
- Author(s)
  Ieguchi Katsuaki, Tomita Takeshi, Yoshiro Maru
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜、日本
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] Identification of calcineurin as a novel therapeutic target in multiple myeloma.2013
- Author(s)
  Imai Y, Ohta E, Wang Y, Kitagawa Y, Ding Y, Yamada O, Maru Y, Motoji T
- Organizer
  14th International Myeloma Workshop
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591409
[Presentation] MLK-HOXA9 and Calcineurin are Novel Therapeutic Targets in Multiple Myeloma2012
- Author(s)
  Yoichi Imai, Eri Ohta, Yanhua Wang, Yukiko Kitagawa, Ye Ding, Osamu Yamda, Yoshiro Maru, and Toshiko Motoji
- Organizer
  アメリカ血液学会総会
- Place of Presentation
  米国、アトランタ
- Data Source
  KAKENHI-PROJECT-23591409
[Presentation] MLL is a novel target of anti-myeloma therapy and it is degraded by inhibitors of histone deacetylase (HDAC) and HSP90.2012
- Author(s)
  Yoichi Imai, Eri Ohta, Yanhua Wang, Ye Ding, Osamu Yamada, Yoshiro Maru, and Toshiko Motoji
- Organizer
  日本血液学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591409
[Presentation] Elucidation of MLL as a novel therapy target and molecular mechanism of inhibitors of HDAC and HSP90 in multiple myeloma2012
- Author(s)
  Yoichi Imai, Eri Ohta, Yanhua Wang, Ye Ding, Osamu Yamda, Yoshiro Maru, and Toshiko Motoji
- Organizer
  日本骨髄腫学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591409
[Presentation] S100A8 amyloid A3 and TLR4 in tumor metastasis2012
- Author(s)
  Maru Y
- Organizer
  4th International Muenster Meeting on Danger Signaling in Autoinflammation
- Place of Presentation
  Muenster, Germany
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] S100A8, amyloid A3, and TLR4 in tumor metastasis2012
- Author(s)
  Maru Yoshiro
- Organizer
  4th International Muenster Meeting on Danger Signaling in　Autoinflammation
- Place of Presentation
  Muenster, Germany
- Year and Date
  2012-04-20
- Invited
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] MLL-HOXA9 and calcineurin are novel therapeutic targets in multiple myeloma2012
- Author(s)
  Imai Y, Ohta E, Wang Y, Kitagawa Y, Ding Y, Yamada O, Maru Y, Motoji T
- Organizer
  54th American Society of Hematology Annual Meeting
- Place of Presentation
  Atlanta, December
- Data Source
  KAKENHI-PROJECT-23591409
[Presentation] Dysregulated lung homeostasis involving the TLR4-SAA3 system establishes lung metastasis2011
- Author(s)
  Maru Y
- Organizer
  Kennedy Institute of Rheumatology, University of Oxford
- Place of Presentation
  London, UK(招待講演)
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] Dysregulated lung homeostasis involving the TLR4-SAA3 system in Clara cells and Eph-ephrin signaling establishes lung metastasis2011
- Author(s)
  Maru Y
- Organizer
  3rd International Kloster Seeon Meeting "Cellular and Molecular Mechanisms of Tumor Progression and Metastasis"
- Place of Presentation
  Kloster Seeon, Germany(招待講演)
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] Regulation of mature versus immature conformation of BCR-ABL2011
- Author(s)
  Maru Y
- Organizer
  13th International Conference on chronic myeloid leukemia : Biology and Therapy
- Place of Presentation
  Estoril, Portugal(招待講演)
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] Homeostatic regulation of endotoxin response by endogenous TLR4 ligands is hijacked by metastatic tumor cells2011
- Author(s)
  Maru Y
- Organizer
  8th international conference on innate immunity
- Place of Presentation
  Crete, Greek(招待講演)
- Year and Date
  2011-06-18
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] Bag1 regulates chaperone-mediated triage decisions on degradation of chronic myelogenous leukemia oncoprotein, BCR-ABL.2010
- Author(s)
  Fujiko Tsukahara, Yoshiro Maru
- Organizer
  16th World congress on basic and clinical pharmacology
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] CHIP works in concert with an Hsc70 co-chaperone to degrade BCR-ABL.2009
- Author(s)
  Yoshiro Maru
- Organizer
  EUROPEAN SCHOOL OF HAEMATOLOGY11 th International Conference CHRONIC MYELOID LEUKEMIA
- Place of Presentation
  Palais des Congres, Bordeaux, France
- Year and Date
  2009-09-11
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] How organ-specific pre-metastatic soil is prepared.2009
- Author(s)
  Yoshiro Maru
- Organizer
  EUROPEAN SCHOOL OF HAEMATOLOGY Interdisciplinary Conference on Angiogenesis
- Place of Presentation
  Hilton Kalastajatorppa, Helsinki, Finland
- Year and Date
  2009-06-06
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] Endogenous ligand-induced activation of TLR4 in pre-metastatic phase is both downstream and upstream of TNF signaling.2009
- Author(s)
  Yoshiro Maru
- Organizer
  12th INTERNATIONAL TNF CONFERENCEAPRIL 27
- Place of Presentation
  San Lorenzo De El Escorial, Madrid, Spain
- Year and Date
  2009-04-27
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] The endogenous TLR4 ligands regulate pre-metastatic soil.2009
- Author(s)
  Yoshiro Maru
- Organizer
  2nd International Kloster Seeon Meeting "Cellular and Molecular Mechanisms of Tumor Progression and Metastasis"
- Place of Presentation
  Kloster Seeon, Germany
- Year and Date
  2009-09-20
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] DNA結合タンパク質C1DのDNA損傷修復過程における動態解析
- Author(s)
  瀧田守親、丸義朗
- Organizer
  平成26年度個体レベルでのがん研究支援活動ワークショップ個体レベルでのがん研究の新展開細胞の可塑性と発がん
- Place of Presentation
  琵琶湖ホテル
- Year and Date
  2015-02-05 – 2015-02-06
- Data Source
  KAKENHI-PROJECT-24700987
[Presentation] S100A8 and lung metastasis
- Author(s)
  Maru Yoshiro
- Organizer
  Seminar in German Cancer Research Center
- Place of Presentation
  Heidelberg, Germany
- Invited
- Data Source
  KAKENHI-PLANNED-21117008
[Presentation] 新規ヌクレオソーム結合タンパク質C1DのDNA損傷修復過程における動態解析
- Author(s)
  瀧田守親、丸義朗
- Organizer
  平成26年度文部科学省新学術領域研究がん研究分野の特性等を踏まえた支援活動公開シンポジウム
- Place of Presentation
  一橋講堂学術総合センター2F
- Year and Date
  2015-01-27 – 2015-01-28
- Data Source
  KAKENHI-PROJECT-24700987

1. TAKITA Morichika (80533455)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. 渋谷正史 (10107427)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. NAKAMURA Sachie (60313087)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. 松七五三仁 (50251442)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 矢花直幸 (90292846)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 後藤典子 (10251448)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MIYAKE Kensuke (60229812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KAISHO Tsuneyasu (60224325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MUTA Tatsushi (60222337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KURATA Shoichiro (90221944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KURANAGA Erina (90376591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OGAWA Yoshihiro (70291424)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. TSUKAHARA Fujiko (40119996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
14. TOMITA Takeshi (20302242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
15. DEGUCHI Atsuko (10422932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
16. IEGUCHI Katsuaki (90586348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
17. IMAI Yoichi (10345209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
18. 東條有伸 (00211681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 櫻井佳子 (10361619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 大場基 (70297018)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 小井川浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Maru Yoshiro 丸 義朗

maru yoshiro 丸 義朗

MARU Yoshiro 丸 義朗

丸 義朗 マル ヨシロウ

Research Projects

Research Products

Co-Researchers

Novel immunothrombosis on premetastatic niche formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Suppression of cancer metastases by hop-derived prenylflavonoids and drug discovery research

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of C1D in metastasis of cancer and drug discovery research

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanism of refractoriness of myeloma mediated by adhesion molecules

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Homeostatic inflammation: Molecular basis and dysregulation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Endogenous TLR4 ligands in tumor metastasis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

3つの新しい運動制御系の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

酸化ストレスを伴う哺乳類細胞の生物学的系における抗酸化分子とチロシンキナーゼPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

BCR-ABLのDNA修復機構における分子生物学的意義の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腫瘍の形成と維持の機構

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

がん遺伝子の単離とヒトがんにおける異常の解明

Principal Investigator

Project Period (FY)

Research Category

Research Institution

がん遺伝子産物の作用機構と増殖シグナルの異常伝達

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] Inflammation and metastasis (2nd edition).2021

Author(s)

Total Pages

Maru Yoshiro 丸義朗

maru yoshiro 丸義朗

MARU Yoshiro 丸義朗

丸義朗マルヨシロウ

[Book] 医学のあゆみ 258巻1号がんの臓器特異的転移を決定する転移ニッチ2016