SHIRAI Tsuyoshi 白井剛

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SHIRAI Tsuyosi 白井剛

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Researcher Number	00262890
Other IDs
Affiliation (Current)	2025: 長浜バイオ大学, バイオサイエンス学部, 教授
Affiliation (based on the past Project Information) *help	2013 – 2024: 長浜バイオ大学, バイオサイエンス学部, 教授 2015: 長浜バイオ大学, 教授 2013 – 2015: 長浜バイオ大学, 公私立大学の部局等, 教授 2011: 長浜バイオ大学, バイオサイエンス学部, 教授 2002 – 2004: 生物分子工学研究所, 情報解析研究部門, 主任研究員 … More 2002 – 2004: 生物分子工学研究所, 生命情報解析部門, 主任研究員 2000 – 2001: 名古屋大学, 工学研究科, 助手 1999 – 2001: 名古屋大学, 大学院・工学研究科, 助手 1998: 名古屋大学, 工学研究科, 助手 1995 – 1996: 名古屋大学, 工学部, 助手 Less
Review Section/Research Field	Principal Investigator Life / Health / Medical informatics / Biophysics / Basic Section 62010:Life, health and medical informatics-related / Transformative Research Areas, Section (III) Except Principal Investigator 応用微生物学・応用生物化学 / Structural biochemistry / Transformative Research Areas, Section (III) / Medium-sized Section 38:Agricultural chemistry and related fields / Basic Section 49050:Bacteriology-related / Life / Health / Medical informatics / Biological Sciences / Physical chemistry / Chemistry related to living body
Keywords	Principal Investigator 生命分子計算 / 生体超分子構造 / 高分子構造・物性 / 生体生命情報学 / X線結晶構造解析 / 分子進化 / モジュール / キメラタンパク質 / ヘモグロビン / グラフ理論 … More / データサイエンス医療 / 祖先型遺伝子 / 機械学習 / 光合成 / ゲノム / プロテオーム / 分子間相互作用 / ゲノムワイド相関解析 / 高分子構造・物性アルゴリズム / アルゴリズム / 分子機械 / プログラム / 糖鎖生物学 / ガレクチン / X線結晶解析 / タンパク質進化 / タンパク工学 … More Except Principal Investigator レクチン / Congerin / P190I / V193P / Acremonium sp.HI-25 / 結晶構造解析 / DNA複製 / ガレクチン / 植物科学 / 情報科学 / 生物物理学 / 植物生理学 / 光合成 / バクテリア / CRISPR-Cas / メタゲノム / CRISPR / ヌクレアーゼ / アーキア / ヌクレアーぜ / ゲノム編集 / 生体防御 / クリスパー / 核様体蛋白質 / 薬剤 / パーシスター / tuberculosis / IDR / 休眠 / DNA凝集 / 天然変性蛋白質 / 薬剤パーシスター / 抗酸菌 / らい菌 / 非結核性抗酸菌 / 結核 / 変異 / ヒトゲノム / 蛋白質立体構造 / バイオインフォマティクス / 蛋白質立体構構造 / ゲノム変異 / 変異の意味づけ / レアバリアント / ヒトタンパク質 / ホモロジーモデリング / タンパク質立体構造 / 低頻度変異 / タンパク質DNA複合体 / Lectin / Carbohydrate recognition / Apoptosis / Galectin / 精密糖鎖認識 / グライコ-ム / 加速進化 / T細胞 / グライコーム / 糖鎖 / 糖鎖認識 / アポトーシス / Alternative splicing / Hydrophobic cluster / Sugar-protein interaction / Human genome annotation / Cyanobacterium genome / 3D-keynote / Module / Prediction of genome function / 疎水殻の自動同定 / 確率的アラインメント法 / タンパク質-リガンド相互作用予測法 / 形質転換 / タンパク質フォールディング / タンパク質立体構造予測 / タンパク質-糖鎖予測 / サブユニット相互作用 / 疎水核 / タンパク質-糖鎖相互作用 / すき間 / ヒトゲノムアノテーション / Het PDB-Navi / タンパク質-リガンド相互作用 / 水和 / タンパク質-RNA相互作用 / FAMSBASE / RNA・タンパク質相互作用 / HetPDB-Navi / タンパク質間ネットワーク / 選択的スプライシング / 疎水クラスタ / 糖鎖-タンパク質相互作用 / ヒトゲノム・アノテーション / らん藻ゲノム / 3Dキーノート / モジュール / ゲノム機能予測 / Upward pH shift / site-specific mutagenesis / Taka-amylaseA promoter / Ascorbate oxidaze / アルコルビン酸オキシダーゼ / 至適pHの中性化 / 部位特異的変異 / タカアミラーゼAプロモーター / アスコルビン酸オキシダーゼ / micro crystal / protein / mirror optics / automatic / X-ray diffraction / crystal analysis / 自動調整光学系 / 高輝度X線 / ミラーミラー集光光学系 / 微小蛋白質結晶 / 蛋白質結晶構造解析 / X線回折 / 微小結晶 / タンパク質 / 集光光学系 / 自動化 / X線回析 / クランプ / 単粒子解析 / 立体構造 / 複合体 / 画像解析 / 生物物理 / 可視化 / 生体分子 / ナノバイオ / 電子顕微鏡 / パオミネラリゼーション / 結晶配向性 / X線構造解析 / 自己組織化 / マトリックスタンパク質 / アラゴナイト結晶 / リコンビナント / ADPリボシルトランスフェラーゼ / ジャカリン様レクチン / バイオミネラリゼーション / バイオテクノロジー / 糖鎖構造認識 / 進化工学 / ランダム変異 / タンパク質工学 / 糖鎖制限酵素 Less

Photosynthesis ubiquity: Supramolecular complexes and their regulations to enable ph otosynthesis all around the globe
- Principal Investigator
  
  栗栖源嗣
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Osaka University
Decoding the environmental adaptation strategies of photo-synthesis system via restoration of ancient proteinsPrincipal Investigator
- Principal Investigator
  
  白井剛
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Higher depeleopemt of disease-drug molecular path graph systemPrincipal Investigator
- Principal Investigator
  
  白井剛
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Molecular Mechanisms of Generation of Individuality and Acquisition of Diversity in Mycobacterium tuberculosis by the Intrinsically Disordered Histone-Like Protein
- Principal Investigator
  
  Matsumoto Sohkichi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Niigata University
Functional analysis of novel Cas protein candidates for development of new genetic engineering technology
- Principal Investigator
  
  Ishino Yoshizumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Kyushu University
Application of supramolecular graph system to GWAS analysesPrincipal Investigator
- Principal Investigator
  
  Shirai Tsuyoshi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Life / Health / Medical informatics
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Construction of analyses basis for understanding rare variants using protein structural information
- Principal Investigator
  
  Kinoshita Kengo
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Life / Health / Medical informatics
- Research Institution
  Tohoku University
Structural study on the clamp PCNA-loading mechanism by the clamp loader RFC
- Principal Investigator
  
  OYAMA Takuji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  University of Yamanashi
Attempts in unifying biological molecular data via graph methodsPrincipal Investigator
- Principal Investigator
  
  Shirai Tsuyoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Life / Health / Medical informatics
- Research Institution
  Nagahama Institute of Bio-Science and Technology
Structural analysis to investigate the coordinating role of DNA clamp in replisome
- Principal Investigator
  
  Mayanagi Kouta
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyushu University
Molecular mechanism of aragonite crystal formation by proteins from Pteria penguin pearl shell, and its application to the development of functional materials
- Principal Investigator
  
  OGAWA Tomohisa
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemistry related to living body
- Research Institution
  Tohoku University
Clarification of Carbohydrate-Recognition Mechanisms of Gralectins which Evolved via Accelerated Substitution and Their Application for Biotechnology
- Principal Investigator
  
  OGAWA Tomohisa
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Tohoku University
実験的・理論的手法を組み合わせたガレクチン天然リガンドの探索Principal Investigator
- Principal Investigator
  
  白井剛
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University
ガレクチンをテンプレートにした糖鎖制限酵素の開発
- Principal Investigator
  
  OGAWA Tomohisa
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Tohoku University
Decoding of genome function and evolution based on the 3D structures of proteins
- Principal Investigator
  
  GO Mitiko
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagahama Institute of Bio-Science and Technology
  Nagoya University
Protein engineering of ascorbate oxidase and its application to clinical diagnostics and food atorage
- Principal Investigator
  
  THUKAGOSHI Norihiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  NAGOYA UNIVERSITY
キメラヘモグロビン結晶構造による蛋白質構造ブロック界面の分子進化機構の研究Principal Investigator
- Principal Investigator
  
  白井剛
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagoya University
モジュール置換キメラグロビンの結晶構造解析Principal Investigator
- Principal Investigator
  
  白井剛
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University
Automatic adjusting system of high-intensity focusing mirror optics using for the collection of X-ray diffraction data from protein micro crystals
- Principal Investigator
  
  YAMANE Takashi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical chemistry
- Research Institution
  Nagoya University

[Book] タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例2023
- Author(s)
  白井　剛
- Total Pages
  4
- Publisher
  技術情報協会
- ISBN
  9784861049958
- Data Source
  KAKENHI-PLANNED-23H04964
[Book] タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例2023
- Author(s)
  白井　剛
- Total Pages
  4
- Publisher
  技術情報協会
- ISBN
  9784861049958
- Data Source
  KAKENHI-PROJECT-23K21721
[Book] Poly(ADP-Ribose) Polymerase2022
- Author(s)
  Ida C, Yamashita S, Eguchi T, Kuroda Y, Nakae S, Nishi Y, Kamemura K, Shirai T, Mizukami T, Tanaka M, Moss J, Miwa M
- Total Pages
  10
- Publisher
  Humana New York, NY
- ISBN
  9781071628911
- Data Source
  KAKENHI-PROJECT-23K21721
[Book] 創薬研究のための相互作用解析パーフェクト2021
- Author(s)
  由良敬, 鈴木博文, 栗栖源嗣，川端　猛，木下賢吾，白井　剛，土方敦司，田之倉優
- Total Pages
  368
- Publisher
  羊土社
- ISBN
  9784758122566
- Data Source
  KAKENHI-PROJECT-23K21721
[Book] バイオインフォマティクス入門第２版2021
- Author(s)
  白井　剛
- Total Pages
  200
- Publisher
  慶應義塾大学出版会
- ISBN
  9784766427912
- Data Source
  KAKENHI-PROJECT-23K21721
[Book] Protein structure analysis and validation in The Encyclopedia of Bioinformatics and Computational Biology2018
- Author(s)
  Shirai T (eds..Guenther, R. and Steel, D)
- Total Pages
  8
- Publisher
  Elsevier
- ISBN
  9780128114148
- Data Source
  KAKENHI-PROJECT-17H01818
[Book] Protein structure analysis and validation, The Encyclopedia of Bioinformatics and Computational Biology2018
- Author(s)
  Shirai T
- Total Pages
  10
- Publisher
  Elsevier
- ISBN
  9780128114148
- Data Source
  KAKENHI-PROJECT-17H01818
[Book] バイオインフォマティクス入門,2015
- Author(s)
  日本バイオインフォマティクス学編（白井剛　編集代表者）
- Total Pages
  176
- Publisher
  慶應義塾大学出版会
- Data Source
  KAKENHI-PROJECT-24370046
[Book] 生命のビッグデータ利用の最前線2014
- Author(s)
  辻　敏之, 白井　剛
- Total Pages
  7
- Publisher
  シーエムシー出版,
- Data Source
  KAKENHI-PROJECT-25280109
[Book] 生命のビッグデータ利用の最前線2014
- Author(s)
  辻　敏之, 白井　剛
- Total Pages
  7
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-25280109
[Book] Methods in Molecular Biology vol. 12002014
- Author(s)
  Ogawa T, Shirai T
- Total Pages
  613
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-24370046
[Book] 生命のビッグデータ利用の最前線2014
- Author(s)
  辻　敏之, 白井　剛
- Total Pages
  231
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-24370046
[Book] Lectins: Methods and Protocols, Methods in Molecular Biology2014
- Author(s)
  Ogawa T, Shirai T
- Total Pages
  13
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25280109
[Book] Protein Engineering - Technology and Application2013
- Author(s)
  Tomohisa Ogawa, Tsuyoshi Shirai
- Total Pages
  22
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-24370046
[Book] Protein Engineering technology and application2013
- Author(s)
  Ogawa T, Shirai T
- Total Pages
  22
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-25280109
[Book] Ribosomal Proteins and Protein Engineering : ISBN:978-1-60741-005-8 (Ed.Ortendhal & Salchow ANCESTRAL PROTEIN RECONSTRUCTION AS A NEW FIELD IN PROTEIN ENGINEERING)2010
- Author(s)
  A.Konno, T.Ogawa, T.Shirai
- Publisher
  Nova Science Publishers, Inc.
- Data Source
  KAKENHI-PROJECT-20350073
[Book] Ancestral protein reconstruction as a new field in protein engineering . In : Ribosomal Proteins and Protein Engineering2010
- Author(s)
  Konno, A., Ogawa, T., Shirai, T.
- Publisher
  Nova Science Publishers, Inc
- Data Source
  KAKENHI-PROJECT-20350073
[Book] Ribosomal Proteins and Protein Engineering2010
- Author(s)
  A.Konn, T.Ogawa, T.Shirai
- Publisher
  ANCESTRAL PROTEIN RECONSTRUCTION AS A NEW FIELD IN P ROTEIN ENGINEERING
- Data Source
  KAKENHI-PROJECT-20350073
[Book] 加速塩基置換による蛋白質の機能・構造の進化2003
- Author(s)
  白井剛, 塩生-光山くらら, 小川智久
- Publisher
  蛋白質核酸酵素,48
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Book] 日本結晶学会誌,442002
- Author(s)
  白井剛
- Publisher
  タンパク質の構造予測とフォールド進化
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] Changes in the hydrophobic network of the FliGMC domain induce rotational switching of the flagellar motor2023
- Author(s)
  Nishikino Tatsuro、Hijikata Atsushi、Kojima Seiji、Shirai Tsuyoshi、Kainosho Masatsune、Homma Michio、Miyanoiri Yohei
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 8 Pages: 107320-107320
- DOI
  10.1016/j.isci.2023.107320
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03220, KAKENHI-PROJECT-23K21721
[Journal Article] Involvement of mTOR pathway in neurodegeneration in NSF-related developmental and epileptic encephalopathy2023
- Author(s)
  Hayashi Takahiro、Yano Naoko、Kora Kengo、Yokoyama Atsushi、Maizuru Kanako、Kayaki Taisei、Nishikawa Kinuko、Osawa Mitsujiro、Niwa Akira、Takenouchi Toshiki、Hijikata Atsushi、Shirai Tsuyoshi、Suzuki Hisato、Kosaki Kenjiro、Saito Megumu K、Takita Junko、Yoshida Takeshi
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 32 Issue: 10 Pages: 1683-1697
- DOI
  10.1093/hmg/ddad008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K12250, KAKENHI-PROJECT-21K15863, KAKENHI-PROJECT-20H03642, KAKENHI-PROJECT-23K21721
[Journal Article] A novel variant of NR5A1, p.R350W implicates potential interactions with unknown co-factors or ligands2023
- Author(s)
  Gau Maki、Suga Ryota、Hijikata Atsushi、Kashimada Ayako、Takagi Masatoshi、Nakagawa Ryuichi、Takasawa Kei、Shirai Tsuyoshi、Kashimada Kenichi、Morio Tomohiro
- Journal Title
  
  Frontiers in Endocrinology
  
  Volume: 13 Pages: 1033074-1033074
- DOI
  10.3389/fendo.2022.1033074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K12250, KAKENHI-PROJECT-23K21721
[Journal Article] Proximity extracellular protein-protein interaction analysis of EGFR using AirID-conjugated fragment of antigen binding2023
- Author(s)
  Yamada Kohdai、Shioya Ryouhei、Nishino Kohei、Furihata Hirotake、Hijikata Atsushi、Kaneko Mika K.、Kato Yukinari、Shirai Tsuyoshi、Kosako Hidetaka、Sawasaki Tatsuya
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 8301-8301
- DOI
  10.1038/s41467-023-43931-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06628, KAKENHI-PROJECT-23K21721, KAKENHI-PROJECT-23K27171
[Journal Article] Two single-point mutations in Ankyrin Repeat one drastically change the threshold temperature of TRPV12023
- Author(s)
  Shogo Hori, Michihiro Tateyama, Tsuyoshi Shirai, Yoshihiro Kubo, Osamu Saitoh
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 2415-2415
- DOI
  10.1038/s41467-023-38051-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06324, KAKENHI-PROJECT-21K06793, KAKENHI-PROJECT-23K21721, KAKENHI-PROJECT-23K27358
[Journal Article] Improvement of Protein Solubility in Macromolecular Crowding during Myoglobin Evolution2022
- Author(s)
  Isogai Yasuhiro、Imamura Hiroshi、Sumi Tomonari、Shirai Tsuyoshi
- Journal Title
  
  Biochemistry
  
  Volume: 61 Issue: 15 Pages: 1543-1547
- DOI
  10.1021/acs.biochem.2c00166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05431, KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-18KK0151, KAKENHI-PROJECT-23K21721
[Journal Article] Intermolecular Interactions between a Membrane Protein and a Glycolipid Essential for Membrane Protein Integration2022
- Author(s)
  Mori Shoko、Nomura Kaoru、Fujikawa Kohki、Osawa Tsukiho、Shionyu Masafumi、Yoda Takao、Shirai Tsuyoshi、Tsuda Shugo、Yoshizawa-Kumagaye Kumiko、Masuda Shun、Nishio Hideki、Yoshiya Taku、Suzuki Sonomi、Muramoto Maki、Nishiyama Ken-ichi、Shimamoto Keiko
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 17 Issue: 3 Pages: 609-618
- DOI
  10.1021/acschembio.1c00882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12211, KAKENHI-PROJECT-19H02843, KAKENHI-PROJECT-20K05738, KAKENHI-PROJECT-21K06037, KAKENHI-PROJECT-22K19262, KAKENHI-PUBLICLY-22H05392, KAKENHI-PROJECT-23K21721, KAKENHI-PROJECT-23K23831, KAKENHI-PROJECT-23K23850
[Journal Article] Role of a bacterial glycolipid in Sec-independent membrane protein insertion2022
- Author(s)
  Nomura K, Mori S, Fujikawa K, Osawa T, Tsuda S, Yoshizawa-Kumagaye K, Masuda S, Nishio H, Yoshiya T, Yoda T, Shionyu M, Shirai T, Nishiyama KI, Shimamoto K.
- Journal Title
  
  Sci Rep.
  
  Volume: 12 Issue: 1 Pages: 12231-12231
- DOI
  10.1038/s41598-022-16304-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K05323, KAKENHI-PROJECT-22K19262, KAKENHI-PUBLICLY-22H05392, KAKENHI-PROJECT-20K05738, KAKENHI-PROJECT-23K21721, KAKENHI-PROJECT-23K23480, KAKENHI-PROJECT-23K23831, KAKENHI-PROJECT-23K23850
[Journal Article] Physiological levels of poly(ADP-ribose) during the cell cycle regulate HeLa cell proliferation2022
- Author(s)
  Yamashita S, Tanaka M, Ida C, Kouyama K, Nakae S, Matsuki T, Tsuda M, Shirai T, Kamemura K, Nishi Y, Moss J, Miwa, M
- Journal Title
  
  Experimental Cell Research
  
  Volume: 417 Issue: 1 Pages: 113163-113163
- DOI
  10.1016/j.yexcr.2022.113163
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21721
[Journal Article] Knowledge-based Modeling of SARS-CoV-2 Proteins and Predicting its Potential Drugs2021
- Author(s)
  HIJIKATA Atsushi、SHIONYU-MITSUYAMA Clara、NAKAE Setsu、SHIONYU Masafumi、OTA Motonori、KANAYA Shigehiko、SHIRAI Tsuyoshi
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 61 Issue: 2 Pages: 102-106
- DOI
  10.2142/biophys.61.102
- NAID
  130008002757
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01818, KAKENHI-PLANNED-20H05932, KAKENHI-PROJECT-23K21721
[Journal Article] Common and unique strategies of myoglobin evolution for deep-sea adaptation of diving mammals2021
- Author(s)
  Isogai Yasuhiro, Imamura Hiroshi, Nakae Setsu, Sumi Tomonari, Takahashi Ken-ichi, Shirai Tsuyoshi
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 8 Pages: 102920-102920
- DOI
  10.1016/j.isci.2021.102920
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K05431, KAKENHI-PROJECT-21K06503, KAKENHI-PROJECT-23K21721
[Journal Article] Structure of mitogen-activated protein kinase kinase 1 in the DFG-out conformation2021
- Author(s)
  Nakae Setsu、Kitamura Maho、Fujiwara Daisuke、Sawa Masaaki、Shirai Tsuyoshi、Fujii Ikuo、Tada Toshiji
- Journal Title
  
  Acta Crystallographica Section F Structural Biology Communications
  
  Volume: 77 Issue: 12 Pages: 459-464
- DOI
  10.1107/s2053230x21011687
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21721
[Journal Article] Current status of structure-based drug repurposing against COVID-19 by targeting SARS-CoV-2 proteins2021
- Author(s)
  Hijikata Atsushi、Shionyu Clara、Nakae Setsu、Shionyu Masafumi、Ota Motonori、Kanaya Shigehiko、Shirai Tsuyoshi
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 18 Issue: 0 Pages: 226-240
- DOI
  10.2142/biophysico.bppb-v18.025
- NAID
  130008106407
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12211, KAKENHI-PROJECT-18H03331, KAKENHI-PLANNED-20H05932, KAKENHI-PROJECT-23K21721
[Journal Article] Potential Anti-COVID-19 Agents, Cepharanthine and Nelfinavir, and Their Usage for Combination Treatment2021
- Author(s)
  H. Ohashi, K. Watashi, W. Saso, K. Shionoya, et al.
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 4 Pages: 335-337
- DOI
  10.1016/j.isci.2021.102367
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K05712, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-PROJECT-19J12155, KAKENHI-ORGANIZER-16H06429, KAKENHI-PROJECT-19J21455, KAKENHI-PROJECT-18K07055, KAKENHI-PROJECT-20K05755, KAKENHI-PROJECT-20K16267, KAKENHI-PROJECT-23K21721
[Journal Article] DNA polymerase D temporarily connects primase to the CMG-like helicase before interacting with proliferating cell nuclear antigen2021
- Author(s)
  Oki Keisuke、Yamagami Takeshi、Nagata Mariko、Mayanagi Kouta、Shirai Tsuyoshi、Adachi Naruhiko、Numata Tomoyuki、Ishino Sonoko、Ishino Yoshizumi
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 49 Issue: 8 Pages: 4599-4612
- DOI
  10.1093/nar/gkab243
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-18K06089, KAKENHI-PROJECT-20J12260, KAKENHI-PROJECT-19H03197, KAKENHI-PROJECT-20H02916, KAKENHI-PROJECT-20K21281, KAKENHI-PROJECT-23K21721
[Journal Article] Evaluating cepharanthine analogues as natural drugs against SARS‐CoV‐22021
- Author(s)
  Hijikata Atsushi、Shionyu‐Mitsuyama Clara、Nakae Setsu、Shionyu Masafumi、Ota Motonori、Kanaya Shigehiko、Hirokawa Takatsugu、Nakajima Shogo、Watashi Koichi、Shirai Tsuyoshi
- Journal Title
  
  FEBS Open Bio
  
  Volume: 12 Issue: 1 Pages: 285-294
- DOI
  10.1002/2211-5463.13337
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12211, KAKENHI-PROJECT-18H03331, KAKENHI-PROJECT-21K15458, KAKENHI-PLANNED-20H05932, KAKENHI-PROJECT-23K21721
[Journal Article] Two conformations of DNA polymerase D-PCNA-DNA, an archaeal replisome complex, revealed by cryo-electron microscopy2020
- Author(s)
  Mayanagi Kouta、Oki Keisuke、Miyazaki Naoyuki、Ishino Sonoko、Yamagami Takeshi、Morikawa Kosuke、Iwasaki Kenji、Kohda Daisuke、Shirai Tsuyoshi、Ishino Yoshizumi
- Journal Title
  
  BMC Biology
  
  Volume: 18 Issue: 1 Pages: 152-152
- DOI
  10.1186/s12915-020-00889-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-18K06089, KAKENHI-PROJECT-20J12260
[Journal Article] Knowledge‐based structural models of SARS‐CoV‐2 proteins and their complexes with potential drugs2020
- Author(s)
  Hijikata Atsushi、Shionyu‐Mitsuyama Clara、Nakae Setsu、Shionyu Masafumi、Ota Motonori、Kanaya Shigehiko、Shirai Tsuyoshi
- Journal Title
  
  FEBS Letters
  
  Volume: 594 Issue: 12 Pages: 1960-1973
- DOI
  10.1002/1873-3468.13806
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-18H03331
[Journal Article] Resurrecting the ancient glow of the fireflies2020
- Author(s)
  Oba Y.、Konishi K.、Yano D.、Shibata H.、Kato D.、Shirai T.
- Journal Title
  
  Science Advances
  
  Volume: 6 Issue: 49 Pages: 5705-5705
- DOI
  10.1126/sciadv.abc5705
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-18K05320
[Journal Article] Overview of the big data bioinformatics symposium (2SCA) at BSJ20192020
- Author(s)
  Shirai Tsuyoshi、Terada Tohru
- Journal Title
  
  Biophysical Reviews
  
  Volume: 12 Issue: 2 Pages: 277-278
- DOI
  10.1007/s12551-020-00639-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01818
[Journal Article] 超分子グラフシステムによるGWAS解析の研究2019
- Author(s)
  土方敦司, 辻敏之, 塩生真史, 白井剛
- Journal Title
  
  細胞
  
  Volume: 51 Pages: 34-38
- Data Source
  KAKENHI-PROJECT-17H01818
[Journal Article] Curcumin Derivatives Verify the Essentiality of ROS Upregulation in Tumor Suppression2019
- Author(s)
  Nakamae Ikuko、Morimoto Tsumoru、Shima Hiroki、Shionyu Masafumi、Fujiki Hisayo、Yoneda-Kato Noriko、Yokoyama Takashi、Kanaya Shigehiko、Kakiuchi Kiyomi、Shirai Tsuyoshi、Meiyanto Edy、Kato Jun-ya
- Journal Title
  
  Molecules
  
  Volume: 24 Issue: 22 Pages: 4067-4067
- DOI
  10.3390/molecules24224067
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12211, KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-17K07387
[Journal Article] Crystallization of Pearl Biomineralization Protein in Microgravity Environments2019
- Author(s)
  Nakae S, Shionyu M, Ogawa T, Shirai T
- Journal Title
  
  International journal of microgravity science and application
  
  Volume: 36 Issue: 1 Pages: 360105
- DOI
  10.15011//jasma.36.360105
- NAID
  130007842633
- ISSN
  2188-9783
- Year and Date
  2019-01-31
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01818
[Journal Article] Pentagamavunon-1 (PGV-1) inhibits ROS metabolic enzymes and suppresses tumor cell growth by inducing M phase (prometaphase) arrest and cell senescence2019
- Author(s)
  Lestari Beni、Nakamae Ikuko、Yoneda-Kato Noriko、Morimoto Tsumoru、Kanaya Shigehiko、Yokoyama Takashi、Shionyu Masafumi、Shirai Tsuyoshi、Meiyanto Edy、Kato Jun-ya
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 14867-14867
- DOI
  10.1038/s41598-019-51244-3
- NAID
  120006732446
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-17K07387
[Journal Article] Single-particle analysis of full-length human poly(ADP-ribose) polymerase 12019
- Author(s)
  Kouyama K, Mayanagi K, Nakae S, Nishi Y, Miwa M, Shirai, T
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 16 Issue: 0 Pages: 59-67
- DOI
  10.2142/biophysico.16.0_59
- NAID
  130007592895
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-18K06089
[Journal Article] Structures of jacalin‐related lectin PPL3 regulating pearl shell biomineralization2018
- Author(s)
  Nakae S, Shionyu M, Ogawa T, Shirai T
- Journal Title
  
  Proteins
  
  Volume: 86 Issue: 6 Pages: 644-653
- DOI
  10.1002/prot.25491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-15K00411
[Journal Article] Direct visualization of DNA baton pass between replication factors bound to PCNA2018
- Author(s)
  Mayanagi Kouta、Ishino Sonoko、Shirai Tsuyoshi、Oyama Takuji、Kiyonari Shinichi、Kohda Daisuke、Morikawa Kosuke、Ishino Yoshizumi
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 16209-16209
- DOI
  10.1038/s41598-018-34176-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K05442, KAKENHI-PROJECT-18K06081, KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-18K06089
[Journal Article] Rotational direction of flagellar motor from the conformation of FliG middle domain in marine Vibrio.2018
- Author(s)
  Nishikino T, Hijikata A, Miyanoiri Y, Onoue Y, Kojima S, Shirai T, Homma M.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 17793-17793
- DOI
  10.1038/s41598-018-35902-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19293, KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-17J11237
[Journal Article] Clinical characteristics of adolescent cases with Type A insulin resistance syndrome caused by heterozygous mutations in the β-subunit of the insulin receptor (INSR) gene2018
- Author(s)
  Takasawa Kei、Tsuji-Hosokawa Atsumi、Takishima Shigeru、Wada Yasunori、Nagasaki Keisuke、Dateki Sumito、Numakura Chikahiko、Hijikata Atsushi、Shirai Tsuyoshi、Kashimada Kenichi、Morio Tomohiro
- Journal Title
  
  Journal of Diabetes
  
  Volume: 11 Issue: 1 Pages: 46-54
- DOI
  10.1111/1753-0407.12797
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15660, KAKENHI-PROJECT-18K18154, KAKENHI-PROJECT-17H01818
[Journal Article] Exonuclease processivity of archaeal replicative DNA polymerase in association with PCNA is expedited by mismatches in DNA.2017
- Author(s)
  Yoda, T., Tanabe, M., Tsuji, T., Yoda, T., Ishino, S., Shirai, T., Ishino, Y., Takeyama, H., and Nishida, H.
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Issue: 1 Pages: 44582-44582
- DOI
  10.1038/srep44582
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242075, KAKENHI-PROJECT-17H01818
[Journal Article] Decoding disease-causing mechanisms of missense mutations from supramolecular structures2017
- Author(s)
  Hijikata A, Tsuji T, Shionyu M, Shirai T
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 8541-8541
- DOI
  10.1038/s41598-017-08902-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01818, KAKENHI-PROJECT-15K00411, KAKENHI-PROJECT-15K21487
[Journal Article] Identification of a mismatch-specific endonuclease in hyperthermophilic Archaea.2016
- Author(s)
  Ishino S, Nishi Y, Oda S, Uemori T, Sagara T, Takatsu N, Yamagami T, Shirai T, Ishino Y.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 124 Issue: 7 Pages: 2977-2086
- DOI
  10.1093/nar/gkw153
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242075, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-25280109
[Journal Article] Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replication.2016
- Author(s)
  Oyama, T., Ishino, S., Shirai, T., Yamagami, T., Nagata, M., Ogino, H., Kusunoki, M., and Ishino, Y.
- Journal Title
  
  Nucleic Acids, Res.
  
  Volume: 44 Issue: 19 Pages: 9509-9517
- DOI
  10.1093/nar/gkw789
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242075, KAKENHI-PROJECT-16J02633, KAKENHI-PROJECT-26440023
[Journal Article] Novel AVPR2 mutation causing partial nephrogenic diabetes insipidus in a Japanese family2016
- Author(s)
  Yamashita S, Hata A, Usui T, Oda H, Hijikata A, Shirai T, Kaneko N, Hata D
- Journal Title
  
  J. Pediatr. Endocrinol. Metab.
  
  Volume: 5 Issue: 5 Pages: 591-596
- DOI
  10.1515/jpem-2015-0323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-25280109, KAKENHI-PROJECT-15K00411, KAKENHI-PROJECT-15K21487
[Journal Article] 超分子モデリングによる創薬支援2015
- Author(s)
  土方敦司、辻　敏之、白井　剛
- Journal Title
  
  SAR News
  
  Volume: 28 Pages: 1-7
- Data Source
  KAKENHI-PROJECT-24370046
[Journal Article] 超分子モデリングによる創薬支援2015
- Author(s)
  土方敦司、辻　敏之、白井　剛
- Journal Title
  
  SAR News
  
  Volume: 28 Pages: 1-7
- Data Source
  KAKENHI-PROJECT-25280109
[Journal Article] Deciphering Supramolecular Structures with Protein-Protein Interaction Network Modeling2015
- Author(s)
  Toshiyuki Tsuji, Takao Yoda, and Tsuyoshi Shirai
- Journal Title
  
  Sci. Rep.
  
  Volume: 5 Issue: 1 Pages: 16341-16341
- DOI
  10.1038/srep16341
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25330355, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-25280109
[Journal Article] The influence of PRNP polymorphisms on human prion disease susceptibility: an update2015
- Author(s)
  Kobayashi A, Teruya K, Matsuura Y, Shirai T, Nakamura Y, Yamada M, Mizusawa H, Mohri S, Kitamoto T.
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 130 Issue: 2 Pages: 159-170
- DOI
  10.1007/s00401-015-1447-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K01804, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-26670435, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-25280109
[Journal Article] Clustering of 3D-Structure Similarity Based Network of Secondary Metabolites Reveals Their Relationships with Biological Activities2014
- Author(s)
  Ohtana Y,Abdullah AA, Amin MA,Huang M,Ono N, Sato T,Sugiura T,Horai H,Nakamura Y,Morita AH, Lange KW,Kibinge NK, Katsuragi T,Shirai T,Kanaya S
- Journal Title
  
  Mol. Inf.
  
  Volume: 33 Issue: 11-12 Pages: 790-801
- DOI
  10.1002/minf.201400123
- NAID
  130005146305
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22108009, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-25280109
[Journal Article] Evaluating Prion Models Based on Comprehensive Mutation Data of Mouse PrP.2014
- Author(s)
  Shirai T, Saito M, Kobayashi A, Asano M, Hizume M, Ikeda S, Teruya K, Morita M, Kitamoto T.
- Journal Title
  
  Structure.
  
  Volume: 22 Issue: 4 Pages: 560-571
- DOI
  10.1016/j.str.2013.12.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23550195, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-24650185, KAKENHI-PROJECT-25257506, KAKENHI-PROJECT-25280109, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26670435
[Journal Article] Aicardi-Goutières syndrome is caused by IFIH1 mutations.2014
- Author(s)
  Oda, H., Nakagawa, K., Abe, J., Awaya, T., Funabiki, M., Hijikata, A., Nishikomori, R., Funatsuka, M., Ohshima, Y., Sugawara, Y., Yasumi, T., Kato, H., Shirai, T., Ohara, O., Fujita, T., Heike, T.
- Journal Title
  
  America Journal of Human Genetics
  
  Volume: 95 Issue: 1 Pages: 121-125
- DOI
  10.1016/j.ajhg.2014.06.007
- NAID
  120005460706
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24115004, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-25280109, KAKENHI-PROJECT-25670474
[Journal Article] データベース解析によるタンパク質リガンドの多様性2013
- Author(s)
  白井　剛
- Journal Title
  
  生化学
  
  Volume: 85 Pages: 671-687
- NAID
  10031195378
- Data Source
  KAKENHI-PROJECT-24370046
[Journal Article] データベース解析によるタンパク質リガンドの多様性2013
- Author(s)
  白井　剛
- Journal Title
  
  生化学
  
  Volume: 85 Pages: 671-687
- NAID
  10031195378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25280109
[Journal Article] Structure of novel enzyme in mannan biodegradation process 4-O-beta-D-mannosyl-D-glucose phosphorylase MGP2013
- Author(s)
  Setsu Nakae, Shigeaki Ito, Mariko Higa, Takeshi Senoura, Jun Wasaki, Atsushi Hijikata, Masafumi Shionyu, Susumu Ito, Tsuyoshi Shirai
- Journal Title
  
  J. Mol. Biol.
  
  Volume: 425 Issue: 22 Pages: 4468-4478
- DOI
  10.1016/j.jmb.2013.08.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370046
[Journal Article] X-ray structure analysis and characterization of AFUEI, an elastase inhibitor from Aspergillus fumigatus2013
- Author(s)
  Mayuko Sakuma, Katsumi Imada, Yoshiyuki Okumura, Kei-ichi Uchiya, Nobuo Yamashita, Kenji Ogawa, Atsushi Hijikata, Tsuyoshi Shirai, Michio Homma, Toshiaki Nikai
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 24 Pages: 17451-17459
- DOI
  10.1074/jbc.m112.433987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-24590164
[Journal Article] Classification of Iigand molecules in PDB with fast heuristics graph match algorithm COMPLIG2012
- Author(s)
  Saito M, Takemura N, Shirai T
- Journal Title
  
  J. Mol. Biol.
  
  Volume: 424 Issue: 5 Pages: 379-390
- DOI
  10.1016/j.jmb.2012.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370046
[Journal Article] 祖先遺伝子推定による古代タンパク質の解析2012
- Author(s)
  白井剛
- Journal Title
  
  生物工学
  
  Volume: 12 Pages: 11-14
- NAID
  110009580295
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370046
[Journal Article] Supramolecule Modeling: The Mechanism of Switching between Polymerization – Proof Reading Modes in DNA Duplication2012
- Author(s)
  白井剛
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 52 Issue: 5 Pages: 246-249
- DOI
  10.2142/biophys.52.246
- NAID
  10030877059
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370046
[Journal Article] Tracing Protein Evolution through Ancestral Structures of Fish Galectin Structure2011
- Author(s)
  A.Konno, A.Kitagawa, M.Watanabe.T.Oeawa, T.Shirai
- Journal Title
  
  Structure
  
  Volume: 19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350073
[Journal Article] Tracing Protein Evolution through Ancestral Structures of Fish Galectin2011
- Author(s)
  Ayumu Konno, Atsushi Kitagawa, Mizuki Watanabe, Tomohisa Ogawa, Tsuyoshi Shirai
- Journal Title
  
  Structure
  
  Volume: 19 Issue: 5 Pages: 711-721
- DOI
  10.1016/j.str.2011.02.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350073, KAKENHI-PUBLICLY-23107505
[Journal Article] Tracing Protein Evolution through Ancestral Structures of Fish Galectin Structure2011
- Author(s)
  A.Konno, A.Kitagawa, M.Watanabe, T.Ogawa, T.Shirai
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350073
[Journal Article] Tracing Protein Evolution through Ancestral Structures of Fish Galectin2011
- Author(s)
  A. Konno, A. Kitagawa, M. Watanabe, T. Ogawa, T. Shirai
- Journal Title
  
  Structure
  
  Volume: 19(5) Pages: 711-721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350073
[Journal Article] Protein engineering of conger eel galectins by tracing of molecular e volution using probable ancestral mutants.2010
- Author(s)
  A.Konno, S.Yonemaru, A.Kit agawa, K.Muramoto, T.Shirai, T.Oeawa
- Journal Title
  
  BMC Evolutionary Biology
  
  Volume: 10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350073
[Journal Article] Protein engineering of conger eel galectins by tracing of molecular evolution using probable ancestral mutants.2010
- Author(s)
  A.Konno, S.Yonemaru, A.Kitagawa, K.Muramoto, T.Shirai, T.Ogawa
- Journal Title
  
  BMC Evolutionary Biology 10:43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350073
[Journal Article] Protein engineering of conger eel galectins by tracing of molecular evolution using probable ancestral mutants2010
- Author(s)
  Konno, A., Yonemaru, S., Kitagawa, A., Muramoto, K., Shirai, T. and Ogawa, T.
- Journal Title
  
  BMC Evolutionary Biology
  
  Volume: 10 Issue: 1 Pages: 43-43
- DOI
  10.1186/1471-2148-10-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350073
[Journal Article] Structure of Rhamnose-binding Lectin CSL3 : Unique Pseudo-tetrameric Architecture of a Pattern Recognition Protein2009
- Author(s)
  Shirai, T., Watanabe, Y., Lee, M.-S., Ogawa, T., Muramoto K.
- Journal Title
  
  J. Mol. Biol.
  
  Volume: 391(2) Pages: 390-403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350073
[Journal Article] Structure of Rhamnose-binding Lectin CSL3 : Unique Pseudo-tetrameric Architecture of a Pattern Recognition Protein.2009
- Author(s)
  Shirai, ら
- Journal Title
  
  J.Mol.Biol. 391
  
  Pages: 390-403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350073
[Journal Article] Structure of Rhamnose-binding Lectin CSL3 : Unique Pseudo-tetrameric Architecture of a Pattern Recognition Protein.2009
- Author(s)
  Shirai T., Watanabe Y., Lee M.-s., Ogawa T., Muramoto K.
- Journal Title
  
  J.Mol.Biol. 391(2)
  
  Pages: 390-403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20350073
[Journal Article] An empirical approach for detecting nucleotide-binding sites on proteins.2006
- Author(s)
  Saito, M., Go, M., Shirai, T.
- Journal Title
  
  Protein Eng Des Sel. 19 (2)
  
  Pages: 67-75
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] In vitro evolutionary thermostabilization of congerin II : a limited repreduction of natural protein evolution by artificial selection pressure2005
- Author(s)
  C.Shionyu-Mitsuyama, Y.Ito, A.Konno, Y.Miwa, T.Ogawa, K.Muramoto, T.Shirai
- Journal Title
  
  Journal of Molecular Biology 347
  
  Pages: 385-397
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] In vitro evolutionary thermostabilization of congerin II : a limited reproduction of natural protein evolution by artificial selection pressure.2005
- Author(s)
  Shionyu-Mitsuyama, C., Ito, Y., Konno, A., Miwa, Y., Ogawa, T., Muramoto, K., Shirai, T.
- Journal Title
  
  J.Mol.Biol. 347
  
  Pages: 385-397
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] In vitro evolutionary thermostabilization of congerin II : a limited reproduction of natural protein evolution by artificial selection pressure.2005
- Author(s)
  Shionyu-Mitsuyama C, Ito Y, Konno A, Miwa Y, Ogawa T, Muramoto K, Shirai T.
- Journal Title
  
  J.Mol.Biol. 347(2)
  
  Pages: 385-397
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14360045
[Journal Article] In vitro evolutionary thermostabilization of congerin II : a limited reproduction of natural protein evolution by artificial selection pressure.2005
- Author(s)
  Shionyu-Mitsuyama, C., Ito, Y., Konno, A., Miwa, Y., Ogawa, T., Muramoto, K., Shirai, T.
- Journal Title
  
  J. Mol. Biol. 347
  
  Pages: 385-397
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] An empirical approach for detecting nucleotide-binding sites on proteins.2005
- Author(s)
  Saito, M., Go, M., Shirai, T.
- Journal Title
  
  Protein Eng Des Sel. 19(2)
  
  Pages: 67-75
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] The speciation of conger eel galectins by rapid adaptive evolution.2004
- Author(s)
  Ogawa, T., Shirai, T., Shionyu-Mitsuyama, C., Yamane, T., Kamiya, H, Muramoto, K.
- Journal Title
  
  Glycoconj.J. 19
  
  Pages: 451-458
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14360045
[Journal Article] The use of ACORN in solving a 39.5 kDa macromolecule with 1.9 A resolution laboratory source data.2004
- Author(s)
  V.Rajakannan, S.Selvanayagam, T.Yamane, T.Shirai, T.Kobayashi, S.Ito, D.Velmurugan
- Journal Title
  
  Journal of Synchrotoron Radiation 11
  
  Pages: 358-362
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] Applications of ACORN to data at 1.45 A resolution.2004
- Author(s)
  V.Rajakannan, T.Yamane, T.Shirai, T.Kobayahi, S.Ito, D.Velmurugan
- Journal Title
  
  Journal of Synchrotoron Radiation 11
  
  Pages: 64-67
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] Translated products of tandem microgene repeats exhibit diverse properties also seen in natural proteins.2003
- Author(s)
  Shiba, K., Shirai, T., Homma, T., Noda, T.
- Journal Title
  
  Protein. Engng. 16
  
  Pages: 57-63
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] An empirical approach for structure-based prediction of carbohydrate-binding sites on proteins.2003
- Author(s)
  Shionyu-Mitsuyama, C., Shirai, T., Ishida, H., Yamane, T.
- Journal Title
  
  Protein. Engng. 16
  
  Pages: 467-478
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] Crystallization and preliminary X-ray study of α-glucosidase from Geobacill us sp. strain HTA-462, one of the deepest sea bacteria.2003
- Author(s)
  Shirai, T., Hung, V.-S., Akita, M., Hatada, Y., Ito, S., Horikoshi, K.
- Journal Title
  
  Acta Cryst. D 59
  
  Pages: 1278-1279
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] Changes of protein structure and function on accelerated evolution : a case of fish galectin2003
- Author(s)
  Shirai, T., Shionyu-Mitsuyama, C., Ogawa, T.
- Journal Title
  
  Tanpakushitsu Kakusan Kouso 48
  
  Pages: 1913-1919
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] The speciation of conger eel galectins by rapid adaptive evolution2003
- Author(s)
  Ogawa, T., Shirai, T., Shionyu-Mitsuyama, C., Yamane, T., Kamiya, H., Muramoto, K.
- Journal Title
  
  Glyco. J. 19
  
  Pages: 451-458
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] An empirical approach for structure-based prediction of carbohydrate-binding sites on proteins2003
- Author(s)
  Shionyu-Mitsuyama, C., Shirai, T., Ishida, H., Yamane, T.
- Journal Title
  
  Protein.Engng. 16
  
  Pages: 467-478
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] The speciation of conger eel galectins by rapid adaptive evolution.2003
- Author(s)
  Ogawa, T., Shirai, T., Shionyu-Mitsuyama, C., Yamane, T., Kamiya, H., Muramoto, K.
- Journal Title
  
  Glyco. J. 19
  
  Pages: 451-458
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] Crystallization and preliminary X-ray study of a-glucosidase from Geobacillus sp. strain HTA-462, one of the deepest sea bacteria2003
- Author(s)
  Shirai, T., Hung, V.-S., Akita, M., Hatada, Y., Ito, S., Horikoshi, K.
- Journal Title
  
  Acta Cryst.D 59
  
  Pages: 1278-1279
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] Translated products of tandem microgene repeats exhibit diverse properties also seen in natural proteins2003
- Author(s)
  Shiba, K., Shirai, T., Homma, T., Noda, T.
- Journal Title
  
  Protein.Engng. 16
  
  Pages: 57-63
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] Crystal structure of a conger eel galectin (congerin II) at 1.45 A resolution : Implication for the accelerated evolution of a new ligand-binding site following gene duplication2002
- Author(s)
  Shirai, T., Matsui, Y., Shionyu-Mitsuyama, C., Yamane, T., Kamiya, H., Ishii, C., Ogawa, T., Muramoto, K.
- Journal Title
  
  J.Mol.Biol. 322
  
  Pages: 879-889
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] Adaptive evolution of conger eel galectins2002
- Author(s)
  Ogawa, T., Shirai, T., Yamane, T., Muramoto, K.
- Journal Title
  
  Trend Glyco. 14
  
  Pages: 177-187
- NAID
  10012195824
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] Crystal structure of a conger eel galectin (congerin II) at 1.45 A resoluti on : Implication for the accelerated evolution of a new ligand-binding site following gene duplication.2002
- Author(s)
  Shirai, T. et al.
- Journal Title
  
  J. Mol. Biol. 322
  
  Pages: 879-889
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] Adaptive evolution of conger eel galectins.2002
- Author(s)
  Ogawa, T., Shirai, T., Yamane, T., Muramoto, K.
- Journal Title
  
  Trend Glyco. 14
  
  Pages: 177-187
- NAID
  10012195824
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] A Protein-Fold Evolution and Protein Structure Predictions2002
- Author(s)
  Shirai, T.
- Journal Title
  
  Journal of the Crystallographic Society of Japan 44
  
  Pages: 20-24
- NAID
  10007767165
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] Crystal structure of alklaine cellulase K : insight into the alkaline adaptation of an industrial enzyme.2001
- Author(s)
  Shirai, T., Ishida, H., Noda, J., Yamane, T., Ozaki, K., Hakamada, Y., Tto.S.
- Journal Title
  
  J. Mol. Biol. 310
  
  Pages: 1079-1087
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Journal Article] Crystal structure of alklaine cellulase K : insight into the alkaline adaptation of an industrial enzyme2001
- Author(s)
  Shirai, T., Ishida, H., Noda, J., Yamane, T., Ozaki, K., Hakamada, Y., Ito, S.
- Journal Title
  
  J.Mol.Biol. 310
  
  Pages: 1079-1087
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12208006
[Patent] Methods of utilizing thermostable mismatch endonuclease2021
- Inventor(s)
  T Uemori, 4名, T Shirai
- Industrial Property Rights Holder
  T Uemori, 4名, T Shirai
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Acquisition Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-23K21721
[Patent] 耐熱性ミスマッチエンドヌクレアーゼ変異体2020
- Inventor(s)
  松本　裕之, 上森隆司, 白井　剛　等
- Industrial Property Rights Holder
  松本　裕之, 上森隆司, 白井　剛　等
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-048795
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-17H01818
[Patent] 耐熱性ミスマッチエンドヌクレアーゼの利用方法2015
- Inventor(s)
  上森隆司, 石野良純, 2名, 白井　剛
- Industrial Property Rights Holder
  上森隆司, 石野良純, 2名, 白井　剛
- Industrial Property Rights Type
  特許
- Filing Date
  2015-09-09
- Overseas
- Data Source
  KAKENHI-PROJECT-25280109
[Patent] 耐熱性ミスマッチエンドヌクレアーゼの利用方法2014
- Inventor(s)
  上森, 石野(園), 相良, 石野(良), 山上, 白井
- Industrial Property Rights Holder
  上森, 石野(園), 相良, 石野(良), 山上, 白井
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-184934
- Filing Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25280109
[Patent] 耐熱性ミスマッチエンドヌクレアーゼの利用方法2014
- Inventor(s)
  上森隆司, 石野良純, 相良武宏, 石野園子, 山上健, 白井剛
- Industrial Property Rights Holder
  上森隆司, 石野良純, 相良武宏, 石野園子, 山上健, 白井剛
- Industrial Property Rights Type
  特許
- Filing Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] すべての生体分子情報がオンラインされた世界での生物学2023
- Author(s)
  白井　剛
- Organizer
  第23回名古屋大学遺伝子実験施設公開セミナー「シン・タンパク質生命科学
- Invited
- Data Source
  KAKENHI-PROJECT-23K21721
[Presentation] 祖先型タンパク質再現による生物の環境適応戦略の解析2023
- Author(s)
  白井　剛
- Organizer
  バイオインタラクション研究会第20回ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-23K21721
[Presentation] Introduction: IDRs as New Drug Targets,2023
- Author(s)
  白井　剛
- Organizer
  日本生物物理学会第61回年会シンポジウム「Biophysical approaches against the drug target proteins involving intrinsically disordered regions」
- Data Source
  KAKENHI-PROJECT-23K21721
[Presentation] 祖先型遺伝子の再現によるタンパク質生体機能進化の研究2023
- Author(s)
  白井　剛
- Organizer
  第834回生医研セミナー(多階層生体防御システム研究拠点)
- Invited
- Data Source
  KAKENHI-PROJECT-23K21721
[Presentation] 光合成ユビキティー：植物はどうして様々な環境で光合成できるようになったのか？2023
- Author(s)
  土方敦司, 白井剛, 坂本亘, 皆川純, 吉田啓亮, 日原由香子, 斉藤圭亮, 栗栖源嗣
- Organizer
  日本科学振興協会(JAAS)年次総会2023 「会いに行ける科学者フェス」
- Invited
- Data Source
  KAKENHI-PLANNED-23H04964
[Presentation] Decoding the environmental adaptation strategies of biological machineries via ancestral proteins2023
- Author(s)
  白井　剛
- Organizer
  日本生物物理学会第61回年会シンポジウム「Understanding the Principles of the Adaptation of Photosynthesis to Diverse Environments」
- Invited
- Data Source
  KAKENHI-PLANNED-23H04964
[Presentation] すべての生体分子情報がオンラインされた世界での生物学2023
- Author(s)
  白井　剛
- Organizer
  第23回名古屋大学遺伝子実験施設公開セミナー「シン・タンパク質生命科学」
- Invited
- Data Source
  KAKENHI-PLANNED-23H04964
[Presentation] どのようにAIと付き合って行くべきか？2023
- Author(s)
  白井　剛
- Organizer
  アジア経済研究会第80回定例会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21721
[Presentation] データサイエンスによる祖先型遺伝子再現と生体機能進化の研究2023
- Author(s)
  白井　剛
- Organizer
  第95回　日本遺伝学会　『ユークリッド遺伝学：ポストDX時代の遺伝学から紐解く生命現象』
- Invited
- Data Source
  KAKENHI-PLANNED-23H04964
[Presentation] 構造情報の生物学における位置付けについて2022
- Author(s)
  白井　剛
- Organizer
  第32回バイオメディカル研究会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21721
[Presentation] Archaea由来エンドヌクレアーゼEndoMSの構造解析と変異体の論理的設計2022
- Author(s)
  白井　剛
- Organizer
  第34回日本 Archaea 研究会講演会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21721
[Presentation] Drug Target eXcavator: 新規ヒト創薬ターゲット探索ツールの開発2021
- Author(s)
  土方敦司, 塩生真史, 白井剛
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K21721
[Presentation] 天然物データベースの高度化と構造創薬への応用2021
- Author(s)
  塩生くらら, 塩生真史, 土方敦司, 太田元規, 金谷重彦, 白井剛
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-23K21721
[Presentation] 「物理の力」で病気と闘う？2021
- Author(s)
  白井剛
- Organizer
  第59回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21721
[Presentation] 疾患―タンパク質―ドラッグのネットワークグラフを用いた新しい創薬ターゲット予測法2021
- Author(s)
  土方敦司, 塩生真史, 白井剛
- Organizer
  第59回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-23K21721
[Presentation] 機械学習による疾患-タンパク質-ドラッグネットワークの解析2020
- Author(s)
  白井剛
- Organizer
  CBI学会2020年大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] DTX: 新規ヒト創薬ターゲット探索のための統合化ウェブツールの開発2020
- Author(s)
  土方敦司、塩生真史、白井剛
- Organizer
  第58回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] A local structural environment descriptor towards evaluating impact of rare variants in humans on protein structures and functions.2019
- Author(s)
  Atsushi Hijikata, Masafumi Shionyu, Tsuyoshi Shirai,
- Organizer
  第57回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] Drug Target Excavator: An Integrative Web Tool for Identifying New Potential Drug Targets.2019
- Author(s)
  Atsushi Hijikata, Masafumi Shionyu, Tsuyoshi Shirai,
- Organizer
  第8回生命医薬情報学連合大会 (IIBMP2019)
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] Drug Target Excavator (DTX)によるVaProSの高度化と創薬ターゲット解析2019
- Author(s)
  白井　剛
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] タンパク質高次構造に基づくヒトミスセンスバリアントの分子機能への影響を予測する手法の開発2019
- Author(s)
  土方敦司、塩生真史、白井剛
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] タンパク質高次構造情報に基づくヒトミスセンス変異の分子機能への影響を予測する手法の開発2019
- Author(s)
  土方敦司、塩生真史、白井剛
- Organizer
  第19回日本蛋白質科学会年会第71回日本細胞生物学会大会合同年次大会
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] 立体構造情報に基づく PLP 結合タンパク質の予測法の開発2018
- Author(s)
  塩生真史, 土方敦司, 白井剛
- Organizer
  第18回蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] Development of a method for predicting pathogenicity of missense variants incorporating supramolecular structural information2018
- Author(s)
  土方敦司、塩生真史、白井剛
- Organizer
  第56回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] 薬物応答性の個人差をタンパク質立体構造から探る2018
- Author(s)
  土方敦司、塩生真史、白井剛
- Organizer
  第18回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] 薬物応答性の個人差をタンパク質立体構造情報から探る2018
- Author(s)
  Atsushi Hijikata, Masafumi Shionyu and Tsuyoshi Shirai
- Organizer
  第7回生命医薬情報学連合大会(IIBMP2018)
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] 薬物応答性の個人差をタンパク質立体構造情報から探る2018
- Author(s)
  土方敦司、塩生真史、白井剛
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] 超分子複合体から読み解くミスセンス変異と疾患表現型との関係2017
- Author(s)
  土方敦司、辻敏之、塩生真史、白井剛
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] Mutation@A Glance: ヒト遺伝子バリアント統合可視化ツール2017
- Author(s)
  土方敦司、白井剛
- Organizer
  トーゴーの日シンポジウム2017
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] Decoding disease-causing mechanisms of missense mutations from supramolecular structures2017
- Author(s)
  土方敦司、辻敏之、塩生真史、白井剛
- Organizer
  第6回生命医薬情報連合大会(IIBMP2017)
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] タンパク質超分子複合体構造から読み解くミスセンス変異と疾患表現型との関係2017
- Author(s)
  土方敦司、辻敏之、塩生真史、白井剛
- Organizer
  第５回NGS現場の会
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] 構造バイオインフォマティクスによる生命現象の理解から創薬支援へ:実践と課題2017
- Author(s)
  白井　剛
- Organizer
  ConBio2017(2017年度生命科学系合同年次大会)
- Invited
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] Mutation@A Glance: ヒトにおける意義不明バリアントの解明を目指した統合解析ツール2017
- Author(s)
  土方敦司、白井剛
- Organizer
  2017年度生命科学系合同年次大会(ConBio2017)
- Data Source
  KAKENHI-PROJECT-17H01818
[Presentation] 結晶構造から明らかになった古細菌GANのDNA複製でのCMG因子および修復でのヌクレアーゼとしての2つの役割2016
- Author(s)
  大山拓次、石野園子、白井剛、山上健、永田麻梨子、尾木野弘実、楠木正巳、石野良純
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26440023
[Presentation] Relationship between protein-protein interaction interface predicted by complex modeling and disease-related amino acid variants2015
- Author(s)
  辻敏之, 依田隆夫, 白井剛
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  石川県金沢市
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] タンパク質相互作用データベースを利用した超分子モデリング法の開発2015
- Author(s)
  辻敏之, 依田隆夫, 白井剛
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島県徳島市
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Structure prediction and analyses of endonuclease NucS from Thermococcus kodakaraensis2015
- Author(s)
  Nakae S, Hijikata A, Tsuji T, Yonezawa K, Kouyama K, Mayanagi K, Ishino S, Ishino Y, Shirai T
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  石川県金沢市
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] マルチドメインタンパク質の構造予測サーバの構築2015
- Author(s)
  塩生真史, 土方敦司, 白井剛
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島県徳島市
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] タンパク質相互作用データベースを利用した超分子モデリング法の開発2015
- Author(s)
  辻敏之, 依田隆夫, 白井剛
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島県徳島市
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] Analyzing disease-related amino acid variants with protein supramolecule modeling2015
- Author(s)
  辻敏之, 依田隆夫, 白井剛
- Organizer
  生命医薬情報学連合大会2015年大会
- Place of Presentation
  京都府宇治市
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] Analyzing disease-related amino acid variants with protein supramolecule modeling2015
- Author(s)
  辻敏之, 依田隆夫, 白井剛
- Organizer
  生命医薬情報学連合大会2015年大会
- Place of Presentation
  京都府宇治市
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Relationship between protein-protein interaction interface predicted by complex modeling and disease-related amino acid variants2015
- Author(s)
  辻敏之, 依田隆夫, 白井剛
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  石川県金沢市
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] マルチドメインタンパク質の構造予測サーバの構築2015
- Author(s)
  塩生真史, 土方敦司, 白井剛
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  徳島県徳島市
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] Development of method for protein-protein interaction modeling using IntAct database2015
- Author(s)
  辻敏之, 依田隆夫, 白井剛
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島県徳島市
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] A statistical amino acid pair potential to re-rank protein-protein docking poses predicted by a vector match algorithm2015
- Author(s)
  Hijikata A, Shionyu M, Shirai T
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  石川県金沢市
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Structure prediction and analyses of endonuclease NucS from Thermococcus kodakaraensis2015
- Author(s)
  Nakae S, Hijikata A, Tsuji T, Yonezawa K, Kouyama K, Mayanagi K, Ishino S, Ishino Y, Shirai T
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  石川県金沢市
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] A method for scoring protein docking-poses on the basis of protein-protein interactions statistics2015
- Author(s)
  Hijikata A, Shionyu M, Shirai T,
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島県徳島市
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] タンパク質超分子モデリングによる疾患関連変異の解析2015
- Author(s)
  辻敏之, 依田隆夫, 白井剛
- Organizer
  生命医薬情報学連合大会2015年大会
- Place of Presentation
  京都府宇治市
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Development of a protein-protein docking method based on matching of vector-presented amino acid residues2015
- Author(s)
  Hijikata A, Shionyu M, Shirai T
- Organizer
  生命医薬情報学連合大会
- Place of Presentation
  京都府宇治市
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] A statistical amino acid pair potential to re-rank protein-protein docking poses predicted by a vector match algorithm2015
- Author(s)
  Hijikata　A, Shionyu M, Shirai T
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  石川県金沢市
- Year and Date
  2015-09-13
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] Development of method for protein-protein interaction modeling using IntAct database2015
- Author(s)
  辻敏之, 依田隆夫, 白井剛
- Organizer
  第15回日本蛋白質科学会年会
- Place of Presentation
  徳島県徳島市
- Year and Date
  2015-06-24
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Development of a protein-protein docking method based on matching of vector-presented amino acid residues2015
- Author(s)
  Hijikata A, Shionyu M, Shirai T
- Organizer
  生命医薬情報学連合大会2015年大会
- Place of Presentation
  京都府宇治市
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] タンパク質超分子モデリングによる疾患関連変異の解析2015
- Author(s)
  辻敏之, 依田隆夫, 白井剛
- Organizer
  生命医薬情報学連合大会2015年大会
- Place of Presentation
  京都府宇治市
- Year and Date
  2015-10-29
- Invited
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] 擬似リン酸化によるMEK1の構造変化2015
- Author(s)
  中江摂, 白井剛, 桐井康行, 多田俊治
- Organizer
  平成27年度日本結晶学会年会
- Place of Presentation
  大阪府堺市
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 超分子モデリングパイプラインの構築による相関構造解析•理論創薬支援2014
- Author(s)
  白井　剛
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-06-25
- Invited
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] イントロダクション:3D遺伝学のすすめ2014
- Author(s)
  白井　剛
- Organizer
  第86回遺伝学会年会
- Place of Presentation
  滋賀県
- Year and Date
  2014-09-19
- Invited
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] 超分子モデリングパイプラインの構築2014
- Author(s)
  白井　剛
- Organizer
  創薬等支援技術基盤プラットフォームテクニカルセミナー2014
- Place of Presentation
  名古屋市
- Year and Date
  2014-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] Supramolecular modeling pipeline for correlative structural analysis and rational drug-design2014
- Author(s)
  白井　剛
- Organizer
  第53回日本生物物理学会年会
- Place of Presentation
  札幌
- Year and Date
  2014-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] 超分子モデリングパイプラインの構築2014
- Author(s)
  白井　剛
- Organizer
  創薬等支援技術基盤プラットフォームテクニカルセミナー2014
- Place of Presentation
  名古屋大学、名古屋
- Year and Date
  2014-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 4-O-β-D-mannosyl-D-glucose phosphorylase (MGP) のＸ線結晶構造解析2013
- Author(s)
  Setsu Nakae,Shigeaki Ito, Mariko Higa, Takeshi Senoura, Jun Wasaki, Atsushi Hijikata, Masafumi Shionyu, Susumu Ito, Tsuyoshi Shirai
- Organizer
  生物物理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Activation mechanism of the replicative helicase in the thermophilic archaeon, Thermoplasma acidophilum2013
- Author(s)
  Hiromi Ogino, Sonoko Ishino, Kouta Mayanagi, Takuji Oyama, Tsuyoshi Shirai, Kosuke Morikawa, Gyri Teien Haugland, Nils-Kare Birkeland, Daisuke Kohda, Yoshizumi Ishino
- Organizer
  Thermophiles 2013
- Place of Presentation
  Regensburg, Germany
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Crystal structure of novel enzyme 4-O-β-D-mannosyl-D glucose phosphorylase with substrate and product molecules2013
- Author(s)
  Setsu Nakae, Shigeaki Ito, Mariko Higa, Takeshi Senoura, Jun Wasaki, Atsushi, Hijikata, Masafumi Shionyu, Susumu Ito Tsuyoshi Shirai
- Organizer
  AsCA'13
- Place of Presentation
  香港
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 組み替えhuman poly(ADP-ribose) polymerase 1の精製とその立体構造解析2013
- Author(s)
  Kenichi Koyama, Takayuki Eguchi, Hiroyuki Morita, Kazuo Kamemura, Yoshisuke Nishi, Masanao Miwa Tsuyoshi Shirai
- Organizer
  生物物理学会年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Activation mechanism of the replicative helicase in the thermophilic archaeon, Thermoplasma acidophilum2013
- Author(s)
  Ogino H, Ishino S, Mayanagi K, Oyama T, Shirai T, Morikawa K, Haugland GT, Birkeland NK, Kohda D, Ishino Y
- Organizer
  Thermophiles 2013
- Place of Presentation
  Regensburg, Germany
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] Divergently evolved activation mechanism of the replicative helicase in the thermophilic archaeon, Thermoplasma acidophilum2013
- Author(s)
  Hiromi Ogino, Sonoko Ishino, Kouta Mayanagi, Takuji Oyama, Tsuyoshi Shirai, Kosuke Morikawa, Gyri Teien Haugland, Nils-Kare Birkeland, Daisuke Kohda, Yoshizumi Ishino
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 好熱性アーキアThermoplasma acidophilumにおける複製ヘリカーゼ活性化機構の分岐進化2013
- Author(s)
  尾木野弘実, 石野園子, 真柳浩太, 大山拓次, 白井剛, 森川耿右, Haugland Gyri Teien, Birkeland Nils-Kare, 神田大輔, 石野良純
- Organizer
  第１４回極限環境生物学会
- Place of Presentation
  川崎
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Electron microscopic analysis of molecular architecture and switching mechanism of DNA replication fork complex2013
- Author(s)
  Kouta Mayanagi, Shinichi Kiyonari, Hirokazu Nishida, Sonoko Ishino, Mihoko Saito, Daisuke Kohda, Yoshizumi Ishino, Tsuyoshi Shirai, Kosuke Morikawa
- Organizer
  ICSG2013-SLS
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Divergently evolved activation mechanism of the replicative helicase in the thermophilic archaeon, Thermoplasma acidophilum2013
- Author(s)
  Ogino H, Ishino S, Mayanagi K, Oyama T, Shirai T, Morikawa K, Haugland GT, Birkeland NK, Kohda D, Ishino Y
- Organizer
  第36回日本分子生物学会
- Place of Presentation
  神戸, 兵庫県
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] 組み替えhuman poly(ADP-ribose) polymerase 1の精製と予備的構造解析2013
- Author(s)
  Kenichi Koyama, Kouta Mayanagi, Takayuki Eguchi, Hiroyuki Morita, Kazuo Kamemura, Yoshisuke Nishi, Masanao Miwa Tsuyoshi Shirai
- Organizer
  第８６回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 好熱性アーキアThermoplasma acidophilumにおける複製ヘリカーゼ活性化機構の分岐進化2013
- Author(s)
  尾木野弘実, 石野園子, 真柳浩太, 大山拓次, 白井剛, 森川耿右, Haugland Gyri Teien, Birkeland Nils-Kare, 神田大輔, 石野良純
- Organizer
  第１４回極限環境生物学会
- Place of Presentation
  川崎, 神奈川県
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] Thermoplasma acidophilum由来Cdc6/Orclとホモ4量体のGINSによるMCMとの相乗的な活性化2012
- Author(s)
  尾木野弘実、石野園子、真柳浩太、大山拓次、白井剛、森川耿右、Gyri Teien Haugland、Nils-Kare Birkeland、石野良純
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Reconstraction of ancestral forms and the evolutionary history of fish galectins reveal their rapid adaptive evolution process2011
- Author(s)
  T. Ogawa, M. Watanabe, A. Konno, K. Muramoto, T. Shirai
- Organizer
  Interlec24
- Place of Presentation
  Brisbane, Austaralia
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-20350073
[Presentation] 魚類卵由来ラムノース結合特異性レクチン(RBL)のX線構造解析による高次構造の解明2009
- Author(s)
  白井剛、小川智久、渡邉康春、李變敏、村本光二
- Organizer
  第3回東北糖鎖研究会
- Place of Presentation
  長岡技術科学大学
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-20350073
[Presentation] Single particle analysis of molecular architecture of DNA replication fork complex and switching mechanism of replication factors
- Author(s)
  Mayanagi K, Kiyonari S, Nishida H, Ishino S, Fujikane R, Saito M, Kohda D, Ishino Y, Shirai T, Morikawa K, Mayanagi K, Kiyonari S, Nishida H, Ishino S, Saito M, Kohda D, Ishino Y, Shirai T, Morikawa
- Organizer
  18th International Microscopy Congress
- Place of Presentation
  Prague Czech, Republic
- Year and Date
  2014-09-07 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Molecular architecture and switching mechanism of the replication fork complex
- Author(s)
  Kouta Mayanagi, Shinichi Kiyonari, Hirokazu Nishida, Sonoko Ishino, Mihoko Saito, Daisuke Kohda, Yoshizumi Ishino, Tsuyoshi Shirai, Kosuke Morikawa
- Organizer
  Gordon Research Conference
- Place of Presentation
  Girona, Spain
- Year and Date
  2014-06-22 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] Single particle analysis of molecular architecture of DNA replication fork complex and switching mechanism of replication factors
- Author(s)
  Kouta Mayanagi, Shinichi Kiyonari, Hirokazu Nishida, Sonoko Ishino, Ryosuke Fujikane, Mihoko Saito, Daisuke Kohda, Yoshizumi Ishino, Tsuyoshi Shirai, Kosuke Morikawa
- Organizer
  18th International Microscopy Congress
- Place of Presentation
  Prague Czech Republic
- Year and Date
  2014-09-07 – 2014-09-12
- Data Source
  KAKENHI-PROJECT-25280109
[Presentation] Supramolecular modeling pipeline for correlative structural analysis and rational drug-design
- Author(s)
  白井　剛
- Organizer
  第５２回日本生物物理学会年会
- Place of Presentation
  札幌コンベンションセンター、札幌
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] イントロダクション:3D遺伝学のすすめ
- Author(s)
  白井　剛
- Organizer
  第86回遺伝学会年会
- Place of Presentation
  長浜バイオ大学、滋賀
- Year and Date
  2014-09-17 – 2014-09-19
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] 超分子モデリングパイプラインの構築による相関構造解析・理論創薬支援
- Author(s)
  白井　剛
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜、横浜
- Year and Date
  2014-06-25 – 2014-06-27
- Invited
- Data Source
  KAKENHI-PROJECT-24370046
[Presentation] Molecular architecture and switching mechanism of the replication fork complex
- Author(s)
  Mayanagi K, Kiyonari S, Nishida H, Ishino S, Saito M, Kohda D, Ishino Y, Shirai T, Morikawa K
- Organizer
  Gordon Research Conference,Three Dimensional Electron Microscopy
- Place of Presentation
  Girona, Spain
- Year and Date
  2014-06-22 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-24370046

1. Mayanagi Kouta (50418571)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
2. ISHINO Yoshizumi (30346837)

# of Collaborated Projects: 4 results

# of Collaborated Products: 18 results
3. OYAMA Takuji (60423133)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. OGAWA Tomohisa (80240901)

# of Collaborated Projects: 3 results

# of Collaborated Products: 14 results
5. MURAMOTO Koji (90157800)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. YAMANE Takashi (80030055)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. YOSHIMI Kyosuke (80230803)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUZUKI Atsuo (40196788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. THUKAGOSHI Norihiro (50115599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KATO Masashi (70242849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
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SHIRAI Tsuyoshi 白井 剛

SHIRAI Tsuyosi 白井 剛

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Decoding the environmental adaptation strategies of photo-synthesis system via restoration of ancient proteinsPrincipal Investigator

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Higher depeleopemt of disease-drug molecular path graph systemPrincipal Investigator

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Application of supramolecular graph system to GWAS analysesPrincipal Investigator

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Attempts in unifying biological molecular data via graph methodsPrincipal Investigator

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実験的・理論的手法を組み合わせたガレクチン天然リガンドの探索Principal Investigator

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SHIRAI Tsuyoshi 白井剛

SHIRAI Tsuyosi 白井剛

[Book] バイオインフォマティクス入門第２版2021