MIZUSHIMA Tohru 水島徹

Researcher Number	00264060
Other IDs
Affiliation (based on the past Project Information) *help	2015: 慶應義塾大学, 薬学部(芝共立), 教授 2011 – 2015: 慶應義塾大学, 薬学部, 教授 2010: 熊本大学, 生命科学研究部, 教授 2009: Kumamoto University, 大学院・生命科学研究部, 教授 2004 – 2008: 熊本大学, 大学院・医学薬学研究部, 教授 … More 2005 – 2006: 熊本大学, 大学院医学薬学研究部, 教授 2004: 熊本大学, 医学薬学研究部, 教授 2004: 熊本大学, 薬学部, 教授 2000 – 2003: 岡山大学, 薬学部, 助教授 1997 – 1998: 岡山大学, 薬学部, 助教授 1995 – 1996: 九州大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Biological pharmacy / Biological pharmacy / Biological Sciences / Functional biochemistry Except Principal Investigator Biological pharmacy / Physical pharmacy
Keywords	Principal Investigator ORC / DNA複製 / ATPase / ATP / Cdc6p / がん / NSAIDs / DnaA / DNAチップ / 抗がん剤 … More / ADP / DNA replication / 真核生物 / アルツハイマー病 / TETRAN / クロージン / アスピリン / 染色体DNA複製 / 活性調節 / Orc5p / プロモーター / DnaA蛋白 / COPD / 鬱病 / proteasome / Saccharomyces cerevisiae / ADP結合 / ORC ATP / Cdc6 / DNA Replication / 結晶構造解析 / 機能ドメイン / 酸性リン脂質 / 活性調和 / anti-cancer drug / Cancer / ストレスタンパク質 / 精神ストレス / うつ病 / ストレス / 病的な炎症 / 自然炎症 / 細胞周期制御 / リン酸化 / pre-RC / 生化学的解析 / βセクレターゼ / βアミロイド / 炎症反応 / HSP70 / モデルマウス / トランスポートソーム / 薬物排泄 / NSAIDs潰瘍 / 非ステロイド系抗炎症薬 / カルシウム / 抗癌作用 / CHOP / βカテニン / HSF1 / 活性酸素種 / 熱ショック蛋白質 / 炎症性サイトカイン / 炎症性腸疾患 / レポータープラスミド / ストレス蛋白質 / アルツハイマー / MATE1 / アニオン性基質 / MFSファミリー / NSAIDs耐性遺伝子 / NSAIDs感受性 / organic anion transporter / 薬物トランスポーター / TPO1 / AKT / クロージン2 / シクロオキシゲナーゼ / 発症リスク / タイトジャンクション / クロージン4 / 抗癌メカニズム / 複製開始制御機構 / 再構成系 / Rad53p / 複製開始反応 / 発がん / 新規抗菌剤 / DNA複製開始反応 / ATP結合 / 網羅的遺伝子解析 / 蛋白質 / MCM / ゲノム / 活性 / 安定化 / 再構成 / 熱ショックタンパク / DNA弛緩反応 / 遺伝子の発現制御 / ノザンブロット解析 / 鞭毛蛋白質 / 大腸菌 / dnaA遺伝子 … More Except Principal Investigator ATPase / ATP / ADP / DnaA / DNA複製 / Non-steroidal anti-inflammatory drug / Liposome / Calcein / Membrane permeability / Membrane potential / Organic ammonium ion / Molecular recognition chemistry / Ion-selective electrode / メラシクロファン誘導体 / カリックス[6]アレーン誘導体 / 分子レセプター / 胃粘膜障害作用 / セロトニン定量 / トリス(2-エチルヘキシル)ホスフィンオキシド / ポルフィリン / 膜透過性変化 / リポソーム / メキシレチン定量 / 有機リン化合物 / 非ステロイド系抗炎症薬 / リボソーム / カルセイン / 膜透過 / 膜電位 / 有機アンモニウムイオン / 分子認識化学 / イオン選択性電極 / regulation of activity / DNA replication / Cdc6p / ATP結合 / 開始因子 / 癌 / 結晶構造解析 / 機能ドメイン / 酸性リン脂質 / ORC / リン脂質 / 活性調節 / Antiporter / Symporter / Unity and diversity / Structure and function / Active transport / アンチポート系 / シンポート系 / 統一性と多様性 / 構造と機能 / 能動輸送系 / 遺伝子制御 / 細胞周期 Less

既承認薬に着目した、アルツハイマー病治療薬のターゲットの発見Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Keio University
精神ストレスによるマイクロエンドフェノタイプに対するストレスタンパク質の効果Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
COPD治療に有効な抗炎症薬開発のための基盤研究Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Keio University
精神ストレスによるマイクロエンドフェノタイプに対するストレスタンパク質の効果Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Mechanism for anti-AD effect of approved medicinesPrincipal Investigator
- Principal Investigator
  
  MIZUSHIMA Tohru
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Keio University
ORCのリン酸化による、細胞周期制御Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
  Kumamoto University
自然炎症、及び病的な炎症における、ストレスタンパク質の役割とその創薬応用Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
  Kumamoto University
NSAIDsの抗癌作用機構の解明とDDSを用いた創薬Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
NSAIDsの輸送タンパク質TETRANの生理的機能と病態における役割Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
βアミロイドの産生、輸送、凝集に対する分子シャペロンの効果Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
真核生物の染色体DNA複製再構成系の確立Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Kumamoto University
Induction of stress proteins by NSAIDs and its role in their pharmacological activityPrincipal Investigator
- Principal Investigator
  
  MIZUSHIMA Tohru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
NSAIDsによるクロージンファミリーの発現変化とその抗癌作用における役割Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
NSAIDs排出ポンプTETRANの機能解析と臨床応用Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Regulation of the activity of ORC.Principal Investigator
- Principal Investigator
  
  MIZUSHIMA Tohru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kumamoto University
蛋白質の活性に着目した、新しい網羅的遺伝子解析の試みPrincipal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
DNA複製開始反応をターゲットとした新規抗菌剤の開発Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
DNA複製関連遺伝子と発がんPrincipal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
真核生物の染色体DNA複製再構成系の確立と複製開始制御機構の解明Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
Development and application of high-performance ion-selective electrodes
- Principal Investigator
  
  KATSU Takashi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  Okayama University
蛋白質の活性に着目した、新しい網羅的遺伝子解析の試みPrincipal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Okayama University
DNA複製関連遺伝子と発がんPrincipal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Okayama University
がん化に伴うDNA複製開始制御の変化Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Okayama University
真核生物の染色体DNA複製再構成系の確立Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Okayama University
がん化に伴うDNA複製開始制御の変化Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Okayama University
Re-constitution of pre-RC complexPrincipal Investigator
- Principal Investigator
  
  MIZUSHIMA Tohru
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  OKAYAMA UNIVERSITY
Tne initiator of chromosomal DNA replication in E. coli.
- Principal Investigator
  
  TSUCHIYA Tomofusa, 黒田照夫
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  OKAYAMA UNIVERSITY
ガン化に伴うDNA複製開始制御の変化と,その抗ガン剤の新規ターゲットとしての応用Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Okayama University
Dna蛋白のATPase活性調節による,DNAの再複製開始抑制機構の解明Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Okayama University
Unity and diversity in active transport in cell membrans
- Principal Investigator
  
  TSUCHIYA Tomofusa
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Okayama University
Site-directed mutagenesis for DnaAPrincipal Investigator
- Principal Investigator
  
  MIZUSHIMA Tohru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Okayama University
大腸菌DnaAタンパク質機能の制御装置の分子機構
- Principal Investigator
  
  片山勉
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
DNA弛緩反応による熱ショック蛋白誘導のメカニズムPrincipal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyushu University
複製開始蛋白DnaAの転写制御における役割Principal Investigator
- Principal Investigator
  
  水島徹
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Kyushu University

All 2015 2014 2013 2012 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Encapsulation of beraprost sodium in nanoparticles: analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension.2015
- Author(s)
  Ishihara, T., Hayashi, E., Yamamoto, S., Kobayashi, C., Tamura, Y., Sawazaki, R., Tamura, F., Tahara, K., Kasahara, T., Ishihara, T., Takenaga, M., Fukuda, K. and Mizushima, T
- Journal Title
  
  J. Control. Release
  
  Volume: 97 Pages: 97-104
- DOI
  10.1016/j.jconrel.2014.10.029
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116524, KAKENHI-PROJECT-26460104, KAKENHI-PROJECT-26350532
[Journal Article] Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity2014
- Author(s)
  Yamakawa, N., Suzuki, K., Yamashita, Y., Katsu, T., Hanaya, K., Shoji, M., Sugai, T. and Mizushima, T.
- Journal Title
  
  Bioorg. & Medic. Chem.
  
  Volume: 22 Issue: 8 Pages: 2529-2534
- DOI
  10.1016/j.bmc.2014.02.032
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Development of biodegradable nanoparticles for liver-specific ribavirin delivery. J2014
- Author(s)
  Ishihara, T., Kaneko, K., Ishihara, T. and Mizushima, T
- Journal Title
  
  J. Pharm. Sci.
  
  Volume: 103 Issue: 12 Pages: 4005-4011
- DOI
  10.1002/jps.24219
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116524, KAKENHI-PROJECT-26350532
[Journal Article] Superiority of pulmonary administration of mepenzolate bromide over other routes as treatment for chronic obstructive pulmonary disease2014
- Author(s)
  Tanaka, K., Kurotsu, S., Asano, T., Yamakawa, N., Kobayashi D., Yamashita, Y., Yamazaki, H., Ishihara, T., Watanabe, H., Maruyama, T., Suzuki, H. and Mizushima, T.
- Journal Title
  
  Sci. Rep.
  
  Volume: 28 Pages: 4510-4510
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Double-blind controlled trial of lecithinized superoxide dismutase in patients with idiopathic interstitial pneumonia, short term evaluation of safety and tolerability.2014
- Author(s)
  Kamio, K., Azuma, A., Ohta, K., Sugiyama, Y., Nukiwa, T. Kudoh, S. and Mizushima, T
- Journal Title
  
  BMC Pulm. Med.
  
  Volume: 14 Issue: 1 Pages: 86-86
- DOI
  10.1186/1471-2466-14-86
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116524
[Journal Article] Diclofenac protects cultured human corneal epithelial cells against hyperosmolarity and ameliorates corneal surface damage in a rat model of dry eye2014
- Author(s)
  Sawazaki, R., Ishihara, T., Usui, S., Hayashi, E., Tahara, K., Hoshino, T., Higuchi, A., Nakamura, S., Tsubota, K. and Mizushima, T.
- Journal Title
  
  Invest. Ophthalmol. Vis. Sci.
  
  Volume: 55 Pages: 2547-2556
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease.2013
- Author(s)
  Tanaka, K., Ishihara, T., Sugizaki, T., Kobayashi D., Yamashita, Y., Tahara, K., Yamakawa, N., Iijima, K., Mogushi, K., Tanaka, H., Sato, K., Suzuki, H. and Mizushima, T.
- Journal Title
  
  Nature Communications
  
  Volume: 4 Pages: 2686-2686
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116524
[Journal Article] Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease2013
- Author(s)
  Tanaka, K., Ishihara, T., Sugizaki, T., Kobayashi D., Yamashita, Y., Tahara, K., Yamakawa, N., Iijima, K., Mogushi, K., Tanaka, H., Sato, K., Suzuki, H. and Mizushima, T.
- Journal Title
  
  Nature Communications
  
  Volume: 4 Pages: 2686-2686
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Chemo-enzymatic enantioconvergent approach toward ethyl shikimate from ethyl 5-hydroxy-3,4-isopropylidenedioxycycloh ex-1-enecarboxylate2013
- Author(s)
  Yamashita, Y., Hanaya, K., Sugai, T., Mizushima, T. and Shoji, M.
- Journal Title
  
  Tetrahedron
  
  Volume: 69 Pages: 6527-6532
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Suppression of UV-induced wrinkle formation by induction of HSP70 expression in mice2013
- Author(s)
  Matsuda, M., Hoshino, T., Yamakawa, N., Tahara, K., Adachi, H., Sobue, G., Maji, D., Ihn, H. and Mizushima, T.
- Journal Title
  
  J. Invest. Dermatol.
  
  Volume: 113 Issue: 4 Pages: 19-28
- DOI
  10.1038/jid.2012.383
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Prostaglandin E1-encapsulated nanoparticles improve walking activity in an experimental rat model of intermittent claudication2013
- Author(s)
  Ishihara, T., Yamashita, Y., Takasaki, N., Yamamoto, S., Hayashi, E., Tahara, K., Takenaga, M., Yamakawa, N., Ishihara, T., Kasahara, T. and Mizushima, T.
- Journal Title
  
  J. Pharm. Pharmacol.
  
  Volume: 65 Pages: 1187-1194
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Suppression of Alzheimer’s disease-related phenotypes by geranylgeranylacetone in mice.2013
- Author(s)
  Hoshino, T., Suzuki, K., Matsushima, T., Yamakawa, N., Suzuki, T. and Mizushima, T.
- Journal Title
  
  PLoS One
  
  Volume: 8
- NAID
  120005365906
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116524
[Journal Article] Comparison of pharmacokinetics between loxoprofen and its derivative with lower ulcerogenic activity, fluoro-loxoprofen2013
- Author(s)
  Yamakawa, N., Suemasu, S., Watanabe, H., Tahara, K., Tanaka, K., Okamoto, Y., Ohtsuka, M., Maruyama, T. and Mizushima, T.
- Journal Title
  
  Drug Metab. Pharmacokinet
  
  Volume: 28 Pages: 118-124
- NAID
  130004933526
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced pulmonary fibrosis progression.2013
- Author(s)
  Tanaka R, Watanabe H, Kodama A, Chuang VT, Ishima Y, Hamasaki K, Tanaka K, Mizushima T, Otagiri M, Maruyama T.
- Journal Title
  
  J Pharmacol Exp Ther.
  
  Volume: 345 Issue: 2 Pages: 271-283
- DOI
  10.1124/jpet.112.201814
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390142, KAKENHI-PROJECT-23659088, KAKENHI-PROJECT-24390043, KAKENHI-PROJECT-24659037, KAKENHI-PROJECT-24659076, KAKENHI-PROJECT-24790077
[Journal Article] Mepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease.2013
- Author(s)
  Tanaka, K., Ishihara, T., Sugizaki, T., Kobayashi D., Yamashita, Y., Tahara, K., Yamakawa, N., Iijima, K., Mogushi, K., Tanaka, H., Sato, K., Suzuki, H. and Mizushima, T.
- Journal Title
  
  Nature Communications
  
  Volume: 4 Pages: 2686-2686
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Suppression of Alzheimer's disease-related phenotypes by geranylgeranylacetone in mice.2013
- Author(s)
  Hoshino, T., Suzuki, K., Matsushima, T., Yamakawa, N., Suzuki, T. and Mizushima, T.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 10 Pages: e76303-e76303
- DOI
  10.1371/journal.pone.0076303
- NAID
  120005365906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Suppression of Alzheimer's disease-related phenotypes by geranygeranylacetone in mice2013
- Author(s)
  Hoshino, T., Suzuki, K., Matsushima, T., Yamakawa, N., Suzuki, T. and Mizushima, T
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 10 Pages: e76306-e76306
- DOI
  10.1371/journal.pone.0076306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-24659037
[Journal Article] Attenuation of acetic acid-induced gastric ulcer formation in rats by glucosylceramide synthase inhibitors.2013
- Author(s)
  Manabu Nakashita
- Journal Title
  
  Dig. Dis. Sci.
  
  Volume: 58 Pages: 354-62
- DOI
  10.1007/s10620-012-2350-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300169, KAKENHI-PROJECT-24659037, KAKENHI-PROJECT-24659103
[Journal Article] Chemo-enzymatic enantioconvergent approach toward ethyl shikimate from ethyl 5-hydroxy-3,4-isopropylidenedioxycyclohex-1-enecarboxylate.2013
- Author(s)
  213. Yamashita, Y., Hanaya, K., Sugai, T., Mizushima, T. and Shoji, M. Chemo-enzymatic enantioconvergent approach toward ethyl shikimate from ethyl 5-hydroxy-3,4-isopropylidenedioxycyclohex-1-enecarboxylate.
- Journal Title
  
  Tetrahedron
  
  Volume: 69 Pages: 6527-6532
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25116524
[Journal Article] Superiority of PC-SOD to other anti-COPD drugs for elastase-induced emphysema and alteration in lung mechanics and respiratory function in mice2012
- Author(s)
  Tanaka, K., Sato, K., Aoshiba, K., Azuma, A. and Mizushima, T.
- Journal Title
  
  Am. J. Physiol. Lung Cell. Mol. Physiol.
  
  Volume: 302 Issue: 12 Pages: L1250-L1261
- DOI
  10.1152/ajplung.00019.2012
- Data Source
  KAKENHI-PROJECT-24659037, KAKENHI-PROJECT-24790077
[Journal Article] Effects of lecithinized superoxide dismutase and/or pirfenidone against bleomycin-induced pulmonary fibrosis2012
- Author(s)
  Tanaka, K., Azuma, A., Miyazaki, Y., Sato, K. and Mizushima, T.
- Journal Title
  
  Chest
  
  Volume: 142 Pages: 1011-1019
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Development of NSAIDs with lower gastric side effect2012
- Author(s)
  Mizushima, T
- Journal Title
  
  Frontier of Gastrointestinal Research
  
  Volume: 30 Pages: 71-78
- DOI
  10.1159/000338396
- ISBN
  9783318021837, 9783318021844
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP_4 receptor2012
- Author(s)
  Hoshino, T., Namba, T., Takehara, M., Murao, N., Sugimoto, Y., Narumiya, S., Matsushima, T., Suzuki, T. and Mizushima, T.
- Journal Title
  
  J. Neurochem.
  
  Volume: 120 Pages: 795-805
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] purification and characterization of hsp-inducers from eupatorium lindleyanum2012
- Author(s)
  Yamashita, Y., Ikeda, T., Matsuda, M., Maji, D., Hoshino, T. and Mizushima, T.
- Journal Title
  
  Biochem. Pharmacol.
  
  Volume: 82 Pages: 909-922
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Effects of β-(1,3-1,6)-D-glucan on irritable bowel syndrome-related colonic hypersensitivity2012
- Author(s)
  Asano, T., Suzuki, H., et al
- Journal Title
  
  Biochem.Biophys.Res.Com.
  
  Volume: 420(2) Issue: 2 Pages: 444-449
- DOI
  10.1016/j.bbrc.2012.03.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300169, KAKENHI-PROJECT-24659037, KAKENHI-PROJECT-24659103, KAKENHI-PROJECT-24790077
[Journal Article] Identification of a unique nsaid, fluoro-loxoprofen with gastroprotective activity.2012
- Author(s)
  Suemasu S., et al.
- Journal Title
  
  Biochem Pharmacol.
  
  Volume: 84 Issue: 11 Pages: 1470-1481
- DOI
  10.1016/j.bcp.2012.09.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06922, KAKENHI-PROJECT-22300169, KAKENHI-PROJECT-23390028, KAKENHI-PROJECT-24659037, KAKENHI-PROJECT-24659048, KAKENHI-PROJECT-24659103, KAKENHI-PROJECT-24790077
[Journal Article] Synthesis and biological evaluation of derivatives of 2-{2-fluoro-4-[(2-oxocyclopentyl)methyl ]phenyl}propanoic acid : Non-steroidal anti-inflammatory drugs with low gastric ulcerogenic activity2012
- Author(s)
  Yamakawa, N., Suemasu, S., Okamoto, Y., Tanaka, K., Ishihara, T., Asano, T., Miyata, k., Ohtsuka, M. and Mizushima, T.
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Pages: 5143-5150
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Expression of 150-kDa oxygen-regulated protein (QRP150) stimulates bleomycin-induced pulmonary fibrosis and dysfunction in mice2012
- Author(s)
  Tanaka, K., et al.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 425 Issue: 4 Pages: 818-824
- DOI
  10.1016/j.bbrc.2012.07.158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J00614, KAKENHI-PROJECT-24659037, KAKENHI-PROJECT-24790077
[Journal Article] Therapeutic effect of lecithinized superoxide dismutase (PC-SOD) against colitis2009
- Author(s)
  Ishihara, T., Tanaka, K., Tasaka, Y., Namba, T., Suzuki, J., Ishihara, T., Okamoto, S., Hibi, T., Takenaga M., Igarashi, R., Sato, K., Mizushima, Y. and Mizushima, T
- Journal Title
  
  J. Pharmacol. Exp. Ther 328
  
  Pages: 152-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Analysis of mutant origin recognition complex with reduced ATPase activity in vivo and in vitro2008
- Author(s)
  Takehara, M., Makise, M., Takenaka, H., Asano, T. and Mizushima, T.
- Journal Title
  
  Biochem. J. 413
  
  Pages: 535-543
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Prolonging the in vivo residence time of prostaglandin E(1) with biodegradable nanoparticles.2008
- Author(s)
  Ishihara, T., Takahashi. M., Higaki, M., Takenaga, M., Mizushima, T. and Mizushima Y.
- Journal Title
  
  Pharm. Res. 25
  
  Pages: 1686-1695
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] NSAIDs suppress the expression of claudin-2 to promote invasion activity of cancer cells2008
- Author(s)
  Mima, S., Takehara, M., Takada, H., Nishimura, T., Hoshino, T., and Mizushima, T.
- Journal Title
  
  Carcinogenesis 10
  
  Pages: 1994-2000
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Analysis of origin recognition complex in Saccharomyces cerevisiae, by use of degron mutants2008
- Author(s)
  Makise, M., Matsui, N., Yamairi, F., Takahashi, M., Takehara, M., Asano, T. and Mizushima, T
- Journal Title
  
  J. Biochem. 43
  
  Pages: 455-465
- NAID
  10024909176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Expression and function of TETRAN, a new type of membrane transporter.2008
- Author(s)
  Ushijima, H., Hiasa, M., Namba, T., Hwang, H-J., Hoshino, T., Mima, S., Tsuchiya, T., Moriyama, Y. and Mizushima, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 374
  
  Pages: 325-330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] a heterodimeric ABC type multidrug efflux pump, in Serratia marcescens2008
- Author(s)
  Matsuo T, Chen, J., Minato, Y., Ogawa, W., Mizushima, T., Kuroda, T. and Tsuchiya T. SmdAB
- Journal Title
  
  J. Bacteriol 190
  
  Pages: 648-654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Development of new type of NSAIDs with lower gastric side effects2008
- Author(s)
  Mizushima, T
- Journal Title
  
  Inflammation and Regeneration 28
  
  Pages: 100-104
- NAID
  10022602322
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Transcriptional activation of ATF6 by endoplasmic reticulum stressors.2007
- Author(s)
  Namba, T., Ishihara, T., Tanaka, K., Hoshino, T. and Mizushima, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 355
  
  Pages: 543-548
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Interaction between ORC and Cdt1p of Saccharomyces cerevisiae2007
- Author(s)
  Asano, T., Makise, M., Takehara, M. and Mizushima, T.
- Journal Title
  
  FEMS Yeast Res 8
  
  Pages: 1256-1262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Genetic evidence for a protective role of heat shock factor 1 against irritant-induced gastric lesions.2007
- Author(s)
  Tanaka, K., Tsutsumi, S., Arai, Y., Hoshino, T., Suzuki, K., Takai, E., Itoh, T., Takeuchi, K., Nakai, A. and Mizushima, T.
- Journal Title
  
  Mol. Pharmacol. 71
  
  Pages: 985-993
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs.2007
- Author(s)
  Mima, S., Ushijima, H., Hwang, H-J., Tsutsumi, S., Makise, M., Yamaguchi, Y., Tsuchiya, T., Mizushima, H. and Mizushima, T.
- Journal Title
  
  FEBS Lett. 581
  
  Pages: 1457-1463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Up-regulation of 150-kDa oxygen-regulated protein (ORP150) by celecoxib in human gastric carcinoma cells.2007
- Author(s)
  Namba, T., Hoshino, T., Tanaka, K., Tsutsumi, S., Ishihara, T., Mima S., Suzuki, K., Ogawa, S. and Mizushima, T.
- Journal Title
  
  Mol. Pharmacol. 71
  
  Pages: 860-870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] an RND-type multidrug efflux transporter in Vibrio parahaemolyticus.2007
- Author(s)
  Matsuo, T., Hayashi, K., Morita, Y., Koterasawa, M., Ogawa, W., Mizushima, T, Tsuchiya, T. and Kuroda, T. VmeAB
- Journal Title
  
  Microbiology 153
  
  Pages: 4129-4137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis2007
- Author(s)
  Tanaka, K. Namba, T., Arai, Y., Fujimoto, M., Adachi, H., Sobue, G., Takeuchi, K., Nakai, A. and Mizushima, T.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 23240-23252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Involvement of up-regulation of PUMA in non-steroidal anti-inflammatory drug-induced apoptosis.2007
- Author(s)
  Ishihara, T., Hoshino, T., Namba, T., Tanaka, K. and Mizushima, T.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 356
  
  Pages: 711-717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Involvement of prostaglandin E_2 in production of amyloid-peptides both in vitro and in vivo.2007
- Author(s)
  Hoshino, T., Nakaya, T., Houman, T., Sugimoto, Y., Araki, W., Narita, M., Narumiya, S., Suzuki, T. and Mizushima, T.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 32676-32688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Simultaneous measurements of K^+ and calcein release from liposomes and the determination of pore size formed in the membrane.2007
- Author(s)
  Katsu, T., Imamura, T., Komagoe, K., Masuda, K. and Mizushima, T.
- Journal Title
  
  Anal. Sci. 23
  
  Pages: 517-522
- NAID
  130004441439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Mechanism for the degradation of origin recognition complex containing Orc5p with a defective walker A motif and its suppression by over-production of Orc4p in yeast cells.2007
- Author(s)
  Makise, M., Takahashi, N., Matsuda, K., Yamairi, F., Suzuki, K., Tsuchiya, T., and Mizushima, T.
- Journal Title
  
  Biochem. J. 402
  
  Pages: 397-403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae : interaction between subunits and identification of binding proteins.2007
- Author(s)
  Matsuda, K., Makise, M., Sueyasu, Y., Takehara, M., Asano, T. and Mizushima, T.
- Journal Title
  
  FEMS Yeast Res. 8
  
  Pages: 1263-1269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Endoplasmic reticulum chaperones inhibit the production of amyloid-・peptides.2007
- Author(s)
  Hoshino, T., Nakaya, T., Araki, W., Suzuki, K., Suzuki, T. and Mizushima, T.
- Journal Title
  
  Biochem. J. 402
  
  Pages: 81-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Various stress proteins protect gastric mucosal cells against non-steroidal anti-inflammatory drugs.2007
- Author(s)
  Mizushima, T.
- Journal Title
  
  Inflammopharmacology 15
  
  Pages: 67-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Molecular cloning and characterization of a multidrug efflux pump, SmfY, from Serratia marcescens.2007
- Author(s)
  Shahcheraghi, F., Minato, Y., Chen, J., Mizushima, T., Ogawa, W., Kuroda, T. and Tsuchiya T.
- Journal Title
  
  Biol Pharm Bull 30
  
  Pages: 798-800
- NAID
  110006271227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Inhibition of both COX-1 and COX-2 and resulting decrease in the level of prostaglandins E2 is responsible for NSAID-dependent exacerbation of colitis
- Author(s)
  Tanaka, K., Suemasu, S., Ishihara, T., Tasaka, Y., Arai, Y. and Mizushima, T
- Journal Title
  
  Eur. J. Pharmacol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Ameliorative effect of mepenzolate bromide against pulmonary fibrosis
- Author(s)
  Kurotsu, S., Tanaka, K., Niino, T., Sugizaki, T., Azuma, A., Suzuki, H. and Mizushima, T.
- Journal Title
  
  J. Pharmacol. Exp. Ther.
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Linkage between phosphorylation of the origin recognition complex and its ATP-binding activity in Saccharomyces cerevisiae.
- Author(s)
  Makise, M., Takehara, M., Kuniyasu, A., Matsui, N., Nakayama, H. and Mizushima, T
- Journal Title
  
  J. Biol. Chem (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Up-regulation of S100P expression by non-steroidal anti-inflammatory drugs and its role in their anti-tumorigenic effects.
- Author(s)
  Namba, T., Houman, T., Nishimura, T., Mima, S., Hoshino, T. and Mizushima, T
- Journal Title
  
  J. Biol. Chem (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Effect of claudin expression on paracellular permeability, migration and invasion of colonic cancer cells
- Author(s)
  Takehara, M., Nishimura, T., Mima, S., Hoshino, T. and Mizushima, T
- Journal Title
  
  Biol. Pharm. Bull (in press)
- NAID
  130000117145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Journal Article] Synthesis and biological comparison of enantiomers of mepenzolate bromide, a muscarinic receptor antagonist with bronchodilatory and anti-inflammatory activities
- Author(s)
  Yamashita, Y., Tanaka, K., Asano, T., Yamakawa, N., Kobayashi D., Ishihara, T., Hanaya, K., Shoji, M., Sugai, T., Wada, M., Mashimo, T., Fukunishi, Y. and Mizushima, T.
- Journal Title
  
  Bioorg. & Medic. Chem.
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-24659037
[Journal Article] Positive role of CHOP, a transcription factor involved in the ER stress response in the development of colitis.
- Author(s)
  Namba, T., Tanaka, K., Ito, Y., Ishihara, T., Hoshino, T., Gotoh, T., Endo, M., Sato, K. and Mizushima, T
- Journal Title
  
  Am. J. Pathol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390023
[Presentation] Case studies of drug repositioning in Japan2009
- Author(s)
  Tohru Mizushima
- Organizer
  Drug repositioning summit
- Place of Presentation
  ボストン、米国 Hyart Harborside Hotel
- Year and Date
  2009-10-13
- Data Source
  KAKENHI-PROJECT-20657028
[Presentation] Case studies of drug repositioning in Japan.2009
- Author(s)
  Tohru Mizushima
- Organizer
  Drug repositioning summit
- Place of Presentation
  ボストン、米国Hyart Harborside Hotel
- Year and Date
  2009-10-13
- Data Source
  KAKENHI-PROJECT-20015037
[Presentation] Case studies of drug repositioning in Japan.2009
- Author(s)
  Tohru Mizushima
- Organizer
  Drug repositioning summit
- Place of Presentation
  ボストン、米国Hyart Harborside Hotel
- Year and Date
  2009-10-13
- Data Source
  KAKENHI-PROJECT-20059026
[Presentation] Case studies of drug repositioning in Japan.2009
- Author(s)
  Tohru Mizushima
- Organizer
  Drug repositioning summit
- Place of Presentation
  ボストン、米国Hyart Harborside Hotel
- Year and Date
  2009-10-13
- Data Source
  KAKENHI-PROJECT-20056025
[Presentation] NSAIDs潰瘍発症の分子機構2008
- Author(s)
  水島徹
- Organizer
  日本潰瘍学会
- Place of Presentation
  札幌
- Year and Date
  2008-09-23
- Data Source
  KAKENHI-PROJECT-19390023
[Presentation] 医薬品開発の新しい流れ--既存薬の研究から新薬へ--2008
- Author(s)
  水島徹
- Organizer
  第2回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-12-21
- Data Source
  KAKENHI-PROJECT-19390023
[Presentation] 副作用の少ない非ステロイド系抗炎症薬の開発2008
- Author(s)
  水島徹
- Organizer
  日本薬学会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-19390023
[Presentation] HSF1、及びHSPsの遺伝子改変マウスを用いた、胃潰瘍、及び炎症性腸疾患に対する生体防御機構研究2008
- Author(s)
  水島徹
- Organizer
  日本薬学会関東支部会
- Place of Presentation
  千葉
- Year and Date
  2008-10-04
- Data Source
  KAKENHI-PROJECT-19390023
[Presentation] 温故知新創薬研究2008
- Author(s)
  水島徹
- Organizer
  第二回熊本創薬シンポジウム
- Place of Presentation
  熊本
- Year and Date
  2008-12-18
- Data Source
  KAKENHI-PROJECT-19390023
[Presentation] トランスクリプトソーム解析による医薬品の副作用機構の解明と、その副作用感受性診断、及び創薬への応用2008
- Author(s)
  水島徹
- Organizer
  創薬バイオマーカー探索研究事業研究発表会
- Place of Presentation
  東京
- Year and Date
  2008-11-06
- Data Source
  KAKENHI-PROJECT-19390023
[Presentation] HSF1ノックアウトマウスの、胃潰瘍、炎症性腸疾患感受性2008
- Author(s)
  水島徹
- Organizer
  日本薬理学会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2008-03-04
- Data Source
  KAKENHI-PROJECT-19390023
[Presentation] 私が受け継ぐ医薬品開発研究--リポ剤の次に来るもの--2008
- Author(s)
  水島徹
- Organizer
  日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2008-10-06
- Data Source
  KAKENHI-PROJECT-19390023
[Presentation] 副作用の少ないNSAIDsの開発物理化学、有機化学、生化学、薬理学など、薬学の総合力を活かした創薬2007
- Author(s)
  水島徹
- Organizer
  生体膜と薬物の相互作用シンポジウム特別企画
- Place of Presentation
  仙台
- Year and Date
  2007-11-10
- Data Source
  KAKENHI-PROJECT-19390023
[Presentation] 胃潰瘍、炎症性腸疾患に対するHSPの保護効果2007
- Author(s)
  水島徹
- Organizer
  日本潰瘍学会
- Place of Presentation
  鳥取
- Year and Date
  2007-09-21
- Data Source
  KAKENHI-PROJECT-19390023
[Presentation] 非ステロイド系抗炎症薬による胃潰瘍発症機構とHSP誘導薬による胃粘膜保護2007
- Author(s)
  水島徹
- Organizer
  九州山口薬学大会
- Place of Presentation
  熊本
- Year and Date
  2007-11-02
- Data Source
  KAKENHI-PROJECT-19390023
[Presentation] 胃潰瘍、炎症性腸疾患に対するHSPの保護効果2007
- Author(s)
  水島徹
- Organizer
  日本フリーラジカル学会
- Place of Presentation
  名古屋
- Year and Date
  2007-05-03
- Data Source
  KAKENHI-PROJECT-19390023
[Presentation] 副作用の少ない非ステロイド系抗炎症薬の開発2007
- Author(s)
  水島徹
- Organizer
  日本炎症・再生学会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-08-04
- Data Source
  KAKENHI-PROJECT-19390023

1. TSUCHIYA Tomofusa (80012673)

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2. KURODA Teruo (80304327)

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3. MASUDA Kazuhumi (00243486)

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4. NEGISHI Kazuo (70116490)

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5. MIO Mitsunobu (70190600)

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6. KOBAYASHI Sakae (90212654)

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7. KATSU Takashi (40112156)

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8. KOMAGOE Keiko (50437563)

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9. 片山勉 (70264059)

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10. 関水和久 (90126095)

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11. 島本整 (90187443)

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12. 月原冨武 (00032277)

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13. KONINGS Wil, N

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14. WISLON Thomas, H

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# of Collaborated Products: 0 results
15. KONINGS Wil

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. WILSON Thoma

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. WATANABE Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. MARUYAMA Toru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. ISHIMA Yu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. SUZUKI Hidekazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 小田切優樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 鈴木利治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MIZUSHIMA Tohru 水島 徹

Research Projects

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Co-Researchers

既承認薬に着目した、アルツハイマー病治療薬のターゲットの発見Principal Investigator

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精神ストレスによるマイクロエンドフェノタイプに対するストレスタンパク質の効果Principal Investigator

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COPD治療に有効な抗炎症薬開発のための基盤研究Principal Investigator

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精神ストレスによるマイクロエンドフェノタイプに対するストレスタンパク質の効果Principal Investigator

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Mechanism for anti-AD effect of approved medicinesPrincipal Investigator

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ORCのリン酸化による、細胞周期制御Principal Investigator

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自然炎症、及び病的な炎症における、ストレスタンパク質の役割とその創薬応用Principal Investigator

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NSAIDsの抗癌作用機構の解明とDDSを用いた創薬Principal Investigator

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NSAIDsの輸送タンパク質TETRANの生理的機能と病態における役割Principal Investigator

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βアミロイドの産生、輸送、凝集に対する分子シャペロンの効果Principal Investigator

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真核生物の染色体DNA複製再構成系の確立Principal Investigator

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Induction of stress proteins by NSAIDs and its role in their pharmacological activityPrincipal Investigator

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NSAIDsによるクロージンファミリーの発現変化とその抗癌作用における役割Principal Investigator

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MIZUSHIMA Tohru 水島徹