Sekimizu Kazuhisa 関水和久

… Alternative Names

Researcher Number	90126095
Other IDs	https://orcid.org/0000-0001-9462-2481
Affiliation (Current)	2019: 帝京大学, 付置研究所, 教授
Affiliation (based on the past Project Information) *help	2019: 帝京大学, 付置研究所, 教授 2016 – 2018: 帝京大学, 医真菌研究センター, 教授 2012 – 2015: 東京大学, 薬学研究科(研究院), 教授 2011: 東京大学, 薬学系研究科, 教授 2010 – 2011: 東京大学, 薬学研究科, 教授 … More
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological Sciences / Biological pharmacy / Functional biochemistry / Environmental pharmacy / Science and Engineering / Drug development chemistry / 物質生物化学 / Molecular biology / Environmental and hygienic pharmacy … More Except Principal Investigator … More
Keywords	Principal Investigator 大腸菌 / 黄色ブドウ球菌 / カイコ / 遺伝子ノックアウトマウス / DNAトポイソメラーゼ / 抗菌剤 / DNA複製 / DNAジャイレース / 感染症 / DNAポリメラーゼ … More Except Principal Investigator 細胞周期 / 温度感受性変異株 / DNA複製 / RB蛋白質 / DnaA蛋白質 / 複製開始 / 感染症 / 大腸菌 / ATP / DnaA / 黄色ブドウ球菌 / デストリン / cdc2キナーゼ / cーmos蛋白質 / DNA複製開始点 / トリコスタチン / ホスファチジルセリン / TGFーβ / cdc2キナ-ゼ / cーmosキナ-ゼ / ヒストンデアセチラ-ゼ / DNA複製開始 / 結晶化 / X線結晶構造解析 / 研究設備 / 基盤的設備 / 大学 / 理工系部局 / 整備水準 / 調査 / 充足度 / 遺伝子制御 / タンパク質 / 抗菌薬 / 作用機序解析 / 細菌 / 肝細胞がん / DCP / 化学療法 / 肝内転移 / 脈管浸潤 / 分子標的治療薬 / 肝細胞癌 / 浸潤 / APN / 血管新生 / イノシトール輸送 / コフィリン / ホルボールエステル / N-myc蛋白質 / DNA複製起点 / 低分子量 / GTP結分蛋白質 / ボツリヌス毒素 / 酵母 / 哺乳類 / 分泌 / ADPリボシル化 / GTP結合蛋白質 / Low molecular weight / GTP-binding protein / Botulinum toxin / Yeast / Mammalian / Secretion / ADP-ribosylation / ストレス応答 / ストレス蛋白質 / 熱ショック蛋白質 / 分子シャペロン / 酸化ストレス / SOS応答 / 転写因子 / プロテアソーム / 細胞骨格 / 転写制御 / 蛋白質の分泌 / タンパク質の分泌 / stress response / stress protein / heat shock protein / molecular chaperone / oxidative stress / SOS response / transcription factor / proteasome / Fプラスミド / DNA分配 / DNAジャイレース / letD(ccdB)遺伝子 / tldD遺伝子 / tldE(pmbA)遺伝子 / zfiA(csrA)遺伝子 / sopB遺伝子 / letB遺伝子 / pbpA遺伝子 / rodA遺伝子 / Fscherichia coli / Eplasmid / DNA gyrase / Partitioning / letD (ccdB) gene / tldD gene / tldE (pmbA) gene / zfiA (csrA) gene / マラリア / 抗マラリア薬 / スクリーニング / アンチセンス / 熱帯熱 / 原虫 / P.falciparum / 標的分子 / ミトコンドリア / ATPase / マラリア治療薬 / スクリーニンヅ / 熱帯熱マラリア / インターネット / Malaria / Anti-malaria drug / Screening / antisense / tropical fever / protozoa / Plasmodium falciparum / target molecule / 染色体 / DNAポリメラーゼ / スラディング・クランプ / スライディング・クランプ / 染色体複製 / otiC / chromosome / DNA replication / DNA polymerase / Sliding clamp / Replicational initiation / Cell cycle / カイコ / 糖尿病 / 高血糖 / トランスクリプトーム解析 / 機能性RNA / 網羅的遺伝子発現解析 Less

Comprehensive analysis of pathogenic ncRNA in host environmentHost ResearcherOngoing
- Host Researcher
  
  関水和久
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Teikyo University
治療効果を指向した新規抗菌薬の創出Principal InvestigatorOngoing
- Principal Investigator
  
  関水和久
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Teikyo University
  The University of Tokyo
Comprehensive understanding of bacterial adaptation mechanism in diabetic host
- Principal Investigator
  
  Matsumoto Yasuhiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Teikyo University
  The University of Tokyo
治療効果を指標に同定された新規抗菌薬の作用機序解析Host Researcher
- Host Researcher
  
  関水和久
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Environmental pharmacy
- Research Institution
  The University of Tokyo
新規リポペプチド系抗生物質カイコシンの標的同定Principal Investigator
- Principal Investigator
  
  関水和久
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Establishment of screening system for antifungal drugs using silkworm fungus infection modelPrincipal Investigator
- Principal Investigator
  
  SEKIMIZU Kazuhisa
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Understanding of host-pathogen interaction by using silkworm infection modelPrincipal Investigator
- Principal Investigator
  
  SEKIMIZU Kazuhisa
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Environmental pharmacy
- Research Institution
  The University of Tokyo
新規病原性遺伝子群を基盤とする病原性発現コアシステムの把握Principal Investigator
- Principal Investigator
  
  関水和久
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Development of novel molecular-targeted medicine against aminopeptidase
- Principal Investigator
  
  KARAKO Takashi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  The University of Tokyo
肝細胞がん特有の進行メカニズムに着目した新規化学療法剤の開発
- Principal Investigator
  
  KARAKO Takashi
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of bacterial pathogenesis system based on a silkworm infection modelPrincipal Investigator
- Principal Investigator
  
  SEKIMIZU Kazuhisa
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
カイコ感染モデルを用いたグラム陽性細菌に保存された病原性発現機構の解明Principal Investigator
- Principal Investigator
  
  関水和久
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
黄色ブドウ球菌の滑走能低下を指標とした抗菌治療薬に関する研究Principal Investigator
- Principal Investigator
  
  関水和久
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
カイコ幼虫における薬物動態に関する研究Principal Investigator
- Principal Investigator
  
  関水和久
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
ヒトに対する病原性細菌の感染モデルとしてのカイコ幼虫の有用性に関する研究Principal Investigator
- Principal Investigator
  
  関水和久
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
マウスDNAトポイソメラーゼIIαの細胞周期制御における役割に関する分子遺伝学Principal Investigator
- Principal Investigator
  
  関水和久
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
マウス初期胚におけるDNAトポイソメラーゼII依存チェックポイント機能低下の可能性Principal Investigator
- Principal Investigator
  
  関水和久
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Functions of transcription elongation factor S-II for cell stress response and developmentPrincipal Investigator
- Principal Investigator
  
  SEKIMIZU Kazuhisa
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
マウスDNAトポイソメラーゼIIαの細胞周期制御における役割に関する分子遺伝学Principal Investigator
- Principal Investigator
  
  関水和久
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
消毒剤耐性変異の獲得に伴うMRSAのβラクタム系抗生物質耐性の上昇Principal Investigator
- Principal Investigator
  
  関水和久
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Development of antibiotics by monitoring the inhibition of the ATP-binding to DnaA, the initiator protein of chromosomal DNA replication in bacteriaPrincipal Investigator
- Principal Investigator
  
  SEKIMIZU Kazuhisa
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Study of the regulatory mechanism of DnaA protein, the initiator of DNA replication in Escherichia coli.Principal Investigator
- Principal Investigator
  
  SEKIMIZU Kazuhisa
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Molecular biology
- Research Institution
  The University of Tokyo
Interaction between the replicational initiator DnaA and the DNA polymerase components
- Principal Investigator
  
  KATAYAMA Tsutomu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  KYUSHU UNIVERSITY
染色体の複製開始の頻度と同時性の制御装置
- Principal Investigator
  
  片山勉
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
マウス個体レベルでの分子シャペロンのDNA超ら旋構造調節に関する分子Principal Investigator
- Principal Investigator
  
  関水和久
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Molecular design of inhibitors for DNA replication in Escherichia coliPrincipal Investigator
- Principal Investigator
  
  SEKIMIZU Kazuhisa
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  KYUSHU UNIVERSITY
大腸菌DnaAタンパク質機能の制御装置の分子機構
- Principal Investigator
  
  KATAYAMA Tsutomu
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
ストレス誘導性のDNAトポロジー変化のヒト細胞での解析Principal Investigator
- Principal Investigator
  
  関水和久
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyushu University
Development of Anti-malarial Drug and it's Molecular Target
- Principal Investigator
  
  WATAYA Yusuke
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Okayama University
Changes of DNA supercoiling in Escherichia coli induced by stressPrincipal Investigator
- Principal Investigator
  
  SEKIMIZU Kazuhisa
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  KYUSHU UNIVERSITY
Biochemical and genetic study of the regulatory mechanism of the chromosomal DNA replication in Escherichia coliPrincipal Investigator
- Principal Investigator
  
  SEKIMIZU Kazuhisa
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  KYUSHU UNIVERSITY
Screening of inhibitors of DNA replication by using the oriC plasmid replication system of Escherichia coliPrincipal Investigator
- Principal Investigator
  
  SEKIMIZU Kazuhisa
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  KYUSHU UNIVERSITY
Principle of Stress Response
- Principal Investigator
  
  YAHARA Ichiro
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
Screaning of E.coli Genes That Participate in the Partitioning of F Plasmid DNA
- Principal Investigator
  
  MIKI Takeyoshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  遺伝
- Research Institution
  KYUSHU UNIVERSITY
A study of the topological change of DNA in Escherichia coli induced by heat shock.Principal Investigator
- Principal Investigator
  
  SEKIMIZU Kazuhisa
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  物質生物化学
- Research Institution
  KYUSHU UNIVERSITY
大学における研究設備の整備充実に関する調査研究
- Principal Investigator
  
  久城育夫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Institution
  The University of Tokyo
Studies on the conformation and functions of ras-related low Mr GTP-binding proteins.
- Principal Investigator
  
  NOZAWA Yoshinori
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  代謝生物化学
- Research Institution
  Gifu University
細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The Institute of Physical and Chemical Research
X線構造解析のためのDNA複製開始系蛋白質dnaAの結晶化
- Principal Investigator
  
  佐藤能雅
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The Institute of Physical and Chemical Research
細胞周期調節に働く癌遺伝子および関連遺伝子に関する研究
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo

[Book] カイコを感染症モデル動物に利用した抗生物質の開拓2010
- Author(s)
  内田龍児、浜本洋、関水和久、供田洋
- Publisher
  バイオサイエンスとインダストリー
- Data Source
  KAKENHI-PUBLICLY-21022015
[Book] カイコを感染症モデル動物に利用した抗生物質の開拓2010
- Author(s)
  内田龍児、浜本洋、関水和久、供田洋
- Publisher
  バイオサイエンスとインダストリー
- Data Source
  KAKENHI-PROJECT-20390021
[Book] 創薬化学の魅力-東京大学大学院薬学系研究科からの発信-2010
- Author(s)
  関水和久、垣内力、浜本洋、松本靖彦
- Publisher
  廣川書店
- Data Source
  KAKENHI-PROJECT-20390021
[Book] Res Adv Antimicrob Agents Chemother2005
- Author(s)
  Hamamoto H, Sekimizu K.
- Total Pages
  23
- Publisher
  Evaluation of the therapeutic effects of antibiotics using silkworm as an animal model.
- Data Source
  KAKENHI-PROJECT-17659015
[Journal Article] Enterococcus faecalis YM0831 suppresses sucrose-induced hyperglycemia in a silkworm model and in humans2019
- Author(s)
  Matsumoto Yasuhiko、Ishii Masaki、Hasegawa Setsuo、Sekimizu Kazuhisa
- Journal Title
  
  Communications Biology
  
  Volume: 2 Pages: 157-157
- DOI
  10.1038/s42003-019-0407-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Silkworm as an experimental animal for research on fungal infections2019
- Author(s)
  Matsumoto Y, Sekimizu K
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 63 Pages: 41-50
- DOI
  10.1111/1348-0421.12668
- NAID
  40021840652
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08288, KAKENHI-PROJECT-15H05783
[Journal Article] Estimation of lactic acid bacterial cell number by DNA quantification2018
- Author(s)
  Ishii M, Matsumoto Y, Sekimizu K
- Journal Title
  
  DD&T
  
  Volume: 12 Issue: 2 Pages: 88-91
- DOI
  10.5582/ddt.2018.01019
- NAID
  130006734006
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08288, KAKENHI-PROJECT-15H05783
[Journal Article] Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic2018
- Author(s)
  Hiroaki Itoh, Kotaro Tokumoto, Takuya Kaji, Atmika Paudel, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue
- Journal Title
  
  Journal of Organic Chemistry
  
  Volume: 印刷中
- DOI
  10.1021/acs.joc.7b02318
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15421, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-17H06110, KAKENHI-PROJECT-16J08733
[Journal Article] Bacterial polysaccharides inhibit sucrose-induced hyperglycemia in silkworms2018
- Author(s)
  Ishii M, Matsumoto Y, Sekimizu K
- Journal Title
  
  DD&T
  
  Volume: 12 Issue: 4 Pages: 185-188
- DOI
  10.5582/ddt.2018.01040
- NAID
  130007484445
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08288, KAKENHI-PROJECT-15H05783
[Journal Article] Utilization of Hybrid Assembly Approach to Determine the Genome of an Opportunistic Pathogenic Fungus, Candida albicans TIMM 17682018
- Author(s)
  Panthee Suresh、Hamamoto Hiroshi、Ishijima Sanae A、Paudel Atmika、Sekimizu Kazuhisa
- Journal Title
  
  Genome Biology and Evolution
  
  Volume: 10 Pages: 2017-2022
- DOI
  10.1093/gbe/evy166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-17F17421
[Journal Article] Establishment of a gnotobiotic silkworm model2018
- Author(s)
  Nakajima H, Matsumoto Y, Sekimizu K
- Journal Title
  
  DD&T
  
  Volume: 12 Issue: 5 Pages: 291-294
- DOI
  10.5582/ddt.2018.01048
- NAID
  130007521061
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08288, KAKENHI-PROJECT-15H05783
[Journal Article] Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model2018
- Author(s)
  Paudel Atmika、Panthee Suresh、Urai Makoto、Hamamoto Hiroshi、Ohwada Tomohiko、Sekimizu Kazuhisa
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 1578-1578
- DOI
  10.1038/s41598-018-19867-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an in vivo evaluation system2018
- Author(s)
 Ishii M, Matsumoto Y, Sekimizu K
- Journal Title
 
 DD&T
 
 Volume: 12 Issue: 3 Pages: 122-125
- DOI
 10.5582/ddt.2018.01028
- NAID
 130007403869
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-17K08288, KAKENHI-PROJECT-15H05783
[Journal Article] Discovery of a new antifungal agent ASP2397 using a silkworm model of Aspergillus fumigatus infection.2017
- Author(s)
  Nakamura, I., Kanasaki, R., Yoshikawa, K., Furukawa, S., Fujie, A., Hamamoto, H., and Sekimizu, K.
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 70 Pages: 41-44
- DOI
  10.1038/ja.2016.106
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus.2017
- Author(s)
  Tabuchi, F., Matsumoto, Y., Ishii, M., Tatsuno, K., Okazaki, M., Sato, T., Moriya, K., and Sekimizu, K.
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 印刷中
- DOI
  10.1038/ja.2017.7
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-26460062
[Journal Article] Isolation of antibiotic-producing Pseudomonas species with low-temperature cultivation of temperate soil2017
- Author(s)
 Mitsutomi S, Sekimizu K, Kaito C
- Journal Title
 
 DD&T
 
 Volume: 11 Issue: 5 Pages: 267-275
- DOI
 10.5582/ddt.2017.01053
- NAID
 130006210826
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-15H04727
[Journal Article] D-cycloserine increases the effectiveness of vancomycin against vancomycin-highly resistant Staphylococcus aureus2017
- Author(s)
  Tabuchi Fumiaki、Matsumoto Yasuhiko、Ishii Masaki、Tatsuno Keita、Okazaki Mitsuhiro、Sato Tomoaki、Moriya Kyoji、Sekimizu Kazuhisa
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 70 Pages: 907-910
- DOI
  10.1038/ja.2017.56
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08288, KAKENHI-PROJECT-17K09023, KAKENHI-PROJECT-15H05783
[Journal Article] Biological activities and antibacterial biomarker of Sesbania grandiflora bark extract2017
- Author(s)
 Anantaworasakul P、Hamamoto H、Sekimizu K、Okonogi S
- Journal Title
 
 DD&T
 
 Volume: 11 Issue: 2 Pages: 70-77
- DOI
 10.5582/ddt.2017.01013
- NAID
 130007040199
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-15H05783
[Journal Article] Anti-Mycobacterium activity of microbial peptides in a silkworm infection model with Mycobacterium smegmatis.2017
- Author(s)
  Yagi Akiho、Uchida Ryuji、Hamamoto Hiroshi、Sekimizu Kazuhisa、Kimura Ken-ichi、Tomoda Hiroshi
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 70 Pages: 685-690
- DOI
  10.1038/ja.2017.23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-16H05095
[Journal Article] Decreased sugar concentration in vegetable and fruit juices by growth of functional lactic acid bacteria2017
- Author(s)
  Ishii M, Matsumoto Y, Nishida S, Sekimizu K
- Journal Title
  
  DD&T
  
  Volume: 11 Issue: 1 Pages: 30-34
- DOI
  10.5582/ddt.2016.01079
- NAID
  130005466206
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460062, KAKENHI-PROJECT-17K08288, KAKENHI-PROJECT-15H05783
[Journal Article] Draft Genome Sequence of the Vancomycin-Resistant Clinical Isolate Staphylococcus aureus VRS3b2017
- Author(s)
  Panthee S, Paudel A, Hamamoto H, Sekimizu K
- Journal Title
  
  Genome Announc
  
  Volume: 5
- DOI
  10.1128/genomea.00452-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Unified Total Synthesis of Polyoxins J, L, and Fluorinated Analogues on the Basis of Decarbonylative Radical Coupling Reactions2017
- Author(s)
  Fujino Haruka、Nagatomo Masanori、Paudel Atmika、Panthee Suresh、Hamamoto Hiroshi、Sekimizu Kazuhisa、Inoue Masayuki
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 56 Pages: 11865-11869
- DOI
  10.1002/anie.201706671
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08156, KAKENHI-PLANNED-17H06452, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-17H06110, KAKENHI-PROJECT-17J09814
[Journal Article] Silkworm fungal infection model for identification of virulence genes in pathogenic fungus and screening of novel antifungal drugs2017
- Author(s)
  Ishii M, Matsumoto Y, Nakamura I, Sekimizu K
- Journal Title
  
  DD&T
  
  Volume: 11 Issue: 1 Pages: 1-5
- DOI
  10.5582/ddt.2016.01080
- NAID
  130005466207
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460062, KAKENHI-PROJECT-17K08288
[Journal Article] Influence of clove oil and eugenol on muscle contraction of silkworm (Bombyx mori)2017
- Author(s)
 Kheawfu K, Pikulkaew S, Hamamoto H, Sekimizu K, Okonogi S
- Journal Title
 
 DD&T
 
 Volume: 11 Issue: 2 Pages: 64-69
- DOI
 10.5582/ddt.2017.01012
- NAID
 130007040200
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
 KAKENHI-PROJECT-15H05783
[Journal Article] Lactobacillus paraplantarum 11-1 Isolated from Rice Bran Pickles Activated Innate Immunity and Improved Survival in a Silkworm Bacterial Infection Model2017
- Author(s)
  Nishida Satoshi、Ishii Masaki、Nishiyama Yayoi、Abe Shigeru、Ono Yasuo、Sekimizu Kazuhisa
- Journal Title
  
  Front Microbiol
  
  Volume: 8 Pages: 436-436
- DOI
  10.3389/fmicb.2017.00436
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] In vitro antibacterial activity and in vivo therapeutic effect of Sesbania grandiflora in bacterial infected silkworms.2017
- Author(s)
  Anantaworasakul, P., Hamamoto, H., Sekimizu, K., and Okonogi, S.
- Journal Title
  
  Pharm Biol
  
  Volume: 55 Pages: 1256-1262
- DOI
  10.1080/13880209.2017.1297467
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Genomic analysis of vancomycin-resistant Staphylococcus aureus VRS3b and its comparison with other VRSA isolates2017
- Author(s)
 Panthee S, Hamamoto H, Paudel A, Sekimizu K
- Journal Title
 
 DD&T
 
 Volume: 11 Issue: 2 Pages: 78-83
- DOI
 10.5582/ddt.2017.01024
- NAID
 130007040198
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15H05783
[Journal Article] Two-spotted cricket as an animal infection model of human pathogenic fungi2017
- Author(s)
  Kochi Yuto、Matsumoto Yasuhiko、Sekimizu Kazuhisa、Kaito Chikara
- Journal Title
  
  DD&T
  
  Volume: 11 Issue: 5 Pages: 259-266
- DOI
  10.5582/ddt.2017.01052
- NAID
  130006210824
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08288, KAKENHI-PROJECT-16K15274, KAKENHI-PROJECT-15H05783
[Journal Article] Advantages of the Silkworm As an Animal Model for Developing Novel Antimicrobial Agents2017
- Author(s)
  Panthee, S., Paudel, A., Hamamoto, H., and Sekimizu, K.
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 8
- DOI
  10.3389/fmicb.2017.00373
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Characterization of the chemical structure and innate immune-stimulating activity of an extracellular polysaccharide from Rhizobium sp. strain M2 screened using a silkworm muscle contraction assay2017
- Author(s)
 Urai Makoto、Aizawa Tomoko、Imamura Katsutoshi、Hamamoto Hiroshi、Sekimizu Kazuhisa
- Journal Title
 
 DD&T
 
 Volume: 11 Issue: 5 Pages: 230-237
- DOI
 10.5582/ddt.2017.01045
- NAID
 130006210838
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-15J04318, KAKENHI-PROJECT-15K07923
[Journal Article] In silico identification of lysocin biosynthetic gene cluster from Lysobacter sp. RH2180-52017
- Author(s)
  Panthee, S., Hamamoto, H., Suzuki, Y., and Sekimizu, K.
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 70 Pages: 204-207
- DOI
  10.1038/ja.2016.102
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] A Novel Spiro-Heterocyclic Compound Identified by the Silkworm Infection Model Inhibits Transcription in Staphylococcus aureus2017
- Author(s)
  Paudel Atmika、Hamamoto Hiroshi、Panthee Suresh、Kaneko Keiichi、Matsunaga Shigeki、Kanai Motomu、Suzuki Yutaka、Sekimizu Kazuhisa
- Journal Title
  
  Front Microbiol
  
  Volume: 8 Pages: 712-712
- DOI
  10.3389/fmicb.2017.00712
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] An invertebrate infection model for evaluating anti-fungal agents against dermatophytosis2017
- Author(s)
  Ishii Masaki、Matsumoto Yasuhiko、Yamada Tsuyoshi、Abe Shigeru、Sekimizu Kazuhisa
- Journal Title
  
  Sci Rep
  
  Volume: 7 Pages: 12289-12289
- DOI
  10.1038/s41598-017-12523-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08288, KAKENHI-PROJECT-15H05783
[Journal Article] Cell-Surface Phenol Soluble Modulins Regulate Staphylococcus aureus Colony Spreading2016
- Author(s)
  Kizaki, H., Omae, Y., Tabuchi, F., Saito, Y., Sekimizu, K., and Kaito, C.
- Journal Title
  
  PLoS One
  
  Volume: 11
- DOI
  10.1371/journal.pone.0164523
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-15H04727
[Journal Article] A critical role of mevalonate for peptidoglycan synthesis in Staphylococcus aureus2016
- Author(s)
  Matsumoto Y, Yasukawa J, Ishii M, Hayashi Y, Miyazaki S, Sekimizu K.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 22864-22864
- DOI
  10.1038/srep22894
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460062, KAKENHI-PROJECT-15H05783
[Journal Article] A hyperglycemic silkworm model for evaluating hypoglycemic activity of Rehmanniae Radix, an herbal medicine2016
- Author(s)
  Matsumoto Y, Sekimizu K.
- Journal Title
  
  DD&T
  
  Volume: 10 Issue: 1 Pages: 14-18
- DOI
  10.5582/ddt.2016.01016
- NAID
  130005133328
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460062, KAKENHI-PROJECT-15H05783
[Journal Article] An Intriguing Correlation Based on the Superimposition of Residue Pairs with Inhibitors that Target Protein-Protein Interfaces2016
- Author(s)
  Nakadai, M., Tomida, S., and Sekimizu, K.
- Journal Title
  
  Scientific reports
  
  Volume: 6 Pages: 18543-18543
- DOI
  10.1038/srep18543
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Identification of lysocin E using a silkworm model of bacterial infection2016
- Author(s)
  Hamamoto, H. Sekimizu, K.
- Journal Title
  
  DD&T
  
  Volume: 10 Issue: 1 Pages: 24-29
- DOI
  10.5582/ddt.2016.01012
- NAID
  130005133325
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-26102714, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-26670043
[Journal Article] Dividing phase-dependent cytotoxicity profiling of human embryonic lung fibroblast identifies candidate anticancer reagents2016
- Author(s)
  Inagaki Y, Matsumoto Y, Tang W, Sekimizu K
- Journal Title
  
  DD&T
  
  Volume: 10 Issue: 4 Pages: 195-200
- DOI
  10.5582/ddt.2016.01049
- NAID
  130005410373
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460062, KAKENHI-PROJECT-15K19873
[Journal Article] Evaluation of anti-diabetic drugs by using silkworm, Bombyx mori 2016
- Author(s)
 Matsumoto Y, Sekimizu K.
- Journal Title
 
 DD&T
 
 Volume: 10 Issue: 1 Pages: 19-23
- DOI
 10.5582/ddt.2016.01017
- NAID
 130005133326
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-26460062, KAKENHI-PROJECT-15H05783
[Journal Article] Using silkworms as a laboratory animal to evaluate medicines and foods2016
- Author(s)
  Sekimizu, K. Hamamoto, H.
- Journal Title
  
  DD&T
  
  Volume: 10 Issue: 1 Pages: 1-2
- DOI
  10.5582/ddt.2016.01018
- NAID
  130005133320
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Using silkworms to establish alternative animal models for evaluation of drug-induced tissue injury2016
- Author(s)
  Inagaki Y, Matsumoto Y, Sekimizu K.
- Journal Title
  
  DD&T
  
  Volume: 10 Issue: 1 Pages: 40-43
- DOI
  10.5582/ddt.2016.01023
- NAID
  130005133318
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460062, KAKENHI-PROJECT-15H05783
[Journal Article] An in vivo invertebrate evaluation system for identifying substances that suppress sucrose-induced postprandial hyperglycemia.2016
- Author(s)
  Matsumoto Y, Ishii M, Sekimizu K
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 26354-26354
- DOI
  10.1038/srep26354
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460062
[Journal Article] Menaquinone as a potential target of antibacterial agents2016
- Author(s)
  Paudel, A., Hamamoto, H., Panthee, S., and Sekimizu, K.
- Journal Title
  
  DD&T
  
  Volume: 10 Issue: 3 Pages: 123-128
- DOI
  10.5582/ddt.2016.01041
- NAID
  130005167357
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Lactic acid bacteria activating innate immunity improve survival in bacterial infection model of silkworm2016
- Author(s)
  Nishida, S. Ono, Y. Sekimizu, K.
- Journal Title
  
  DD&T
  
  Volume: 10 Issue: 1 Pages: 49-56
- DOI
  10.5582/ddt.2016.01022
- NAID
  130005133322
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Total Synthesis and Functional Evaluation of Fourteen Derivatives of Lysocin E: Importance of Cationic, Hydrophobic, and Aromatic Moieties for Antibacterial Activity2016
- Author(s)
  T. Kaji, M. Murai, H. Itoh, J. Yasukawa, H. Hamamoto, K. Sekimizu, M. Inoue
- Journal Title
  
  Chemistry - A European Journal
  
  Volume: 22 Pages: 16912-16919
- DOI
  10.1002/chem.201604022
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H01130, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-15H06156, KAKENHI-PROJECT-16J08733
[Journal Article] Usefulness of silkworm as a host animal for understanding pathogenicity of Cryptococcus neoformans 2016
- Author(s)
 Ishii M, Matsumoto Y, Sekimizu K.
- Journal Title
 
 DD&T
 
 Volume: 10 Issue: 1 Pages: 9-13
- DOI
 10.5582/ddt.2016.01015
- NAID
 130005133327
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-26460062, KAKENHI-PROJECT-15H05783
[Journal Article] A silkworm infection model to study the Vibrio vulnificus virulence genes.2016
- Author(s)
  Yamamoto, M., Kashimoto, T., Yoshimura, Y., Tachibana, N., Kuroda, S., Miki, Y., Kitabayashi, S., Tong, P., Xiao, J., Tanaka, K., Hamamoto, H., Sekimizu, K., and Yamamoto, K.
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 14 Pages: 4243-4247
- DOI
  10.3892/mmr.2016.5782
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-26850087, KAKENHI-PROJECT-16K00655
[Journal Article] Multidrug-Resistance Transporter AbcA Secretes Staphylococcus aureus Cytolytic Toxins2016
- Author(s)
  Yoshikai, H. Kizaki, H. Saito, Y. Omae, Y. Sekimizu, K. Kaito, C.
- Journal Title
  
  J Infect Dis
  
  Volume: 213 Pages: 295-304
- DOI
  10.1093/infdis/jiv376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] A human pathogenic bacterial infection model using the two-spotted cricket, Gryllus bimaculatus.2016
- Author(s)
  Kochi, Y., Miyashita, A., Tsuchiya, K., Mitsuyama, M., Sekimizu, K., and Kaito, C.
- Journal Title
  
  FEMS Microbiology Lett.
  
  Volume: 363
- DOI
  10.1093/femsle/fnw163
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-26460523, KAKENHI-PROJECT-16K15274
[Journal Article] Acute oral toxicity test of chemical compounds in silkworms2016
- Author(s)
  Usui K, Nishida S, Sugita T, Ueki T, Matsumoto Y, Okumura H, Sekimizu K.
- Journal Title
  
  DD&T
  
  Volume: 10 Issue: 1 Pages: 57-61
- DOI
  10.5582/ddt.2016.01025
- NAID
  130005133319
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460062, KAKENHI-PROJECT-15H05783
[Journal Article] Lysobacter species: a potential source of novel antibiotics.2016
- Author(s)
  Panthee, S., Hamamoto, H., Paudel, A., and Sekimizu, K.
- Journal Title
  
  Archives of microbiology
  
  Volume: 9 Pages: 839-845
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H05783
[Journal Article] Diabetic silkworms for evaluation of therapeutically effective drugs against type II diabetes.2015
- Author(s)
  Matsumoto Y, Ishii M, Hayashi Y, Miyazaki S, Sugita T, Sumiya E, Sekimizu K.
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Pages: 10722-10722
- DOI
  10.1038/srep10722
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460062, KAKENHI-PROJECT-26860183
[Journal Article] Phenotypic and genomic comparisons of highly vancomycin-resistant Staphylococcus aureus strains developed from multiple clinical MRSA strains by in vitro mutagenesis2015
- Author(s)
  Ishii K, Tabuchi F, Matsuo M, Tatsuno K, Sato T, Okazaki M, Hamamoto H, Matsumoto Y, Kaito C, Aoyagi T, Hiramatsu K, Kaku M, Moriya K, Sekimizu K.
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Pages: 17092-17092
- DOI
  10.1038/srep17092
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460062, KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-15H05279, KAKENHI-PROJECT-26670043
[Journal Article] Niemann-Pick disease type C2 protein induces autophagy and inhibits growth in FM3A breast cancer cells2015
- Author(s)
  Adachi T, Matsumoto Y, Inagaki Y, Sekimizu K
- Journal Title
  
  DD&T
  
  Volume: - Issue: 4 Pages: 282-288
- DOI
  10.5582/ddt.2015.01014
- NAID
  130005098741
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12J10784, KAKENHI-PROJECT-26460062
[Journal Article] Compounds in a particular production lot of tryptic soy broth inhibit Staphylococcus aureus cell growth2015
- Author(s)
 Ishii M, Matsumoto Y, Sekimizu K.
- Journal Title
 
 DD&T
 
 Volume: 9 Issue: 3 Pages: 178-183
- DOI
 10.5582/ddt.2015.01030
- NAID
 130005088586
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-26460062
[Journal Article] Usefulness of silkworm as a model animal for understanding the molecular mechanisms of fungal pathogenicity2015
- Author(s)
  Ishii M, Matsumoto Y, Sekimizu K.
- Journal Title
  
  DD&T
  
  Volume: 9 Issue: 4 Pages: 234-237
- DOI
  10.5582/ddt.2015.01052
- NAID
  130005098742
- ISSN
  1881-7831, 1881-784X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460062
[Journal Article] Fluorescence imaging for a noninvasive in vivo toxicity-test using a transgenic silkworm expressing green fluorescent protein.2015
- Author(s)
  Inagaki Y, Matsumoto Y, Ishii M, Uchino K, Sezutsu H, Sekimizu K
- Journal Title
  
  Sci Rep.
  
  Volume: 5 Pages: 11180-11180
- DOI
  10.1038/srep11180
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460062, KAKENHI-PROJECT-15K19873
[Journal Article] A novel mutation in the vraS gene of Staphylococcus aureus contributes to reduce susceptibility against daptomycin2015
- Author(s)
  Su J, Iehara M, Yasukawa J, Matsumoto Y, Hamamoto H, Sekimizu K
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 印刷中 Pages: 646-648
- DOI
  10.1038/ja.2015.42
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24689008, KAKENHI-PROJECT-26460062, KAKENHI-PUBLICLY-26102714
[Journal Article] Identification and methods for prevention of Enterococcus mundtii infection in silkworm larvae, Bombyx mori, reared on artificial diet2015
- Author(s)
 Nwibo DD, Matsumoto Y, Sekimizu K.
- Journal Title
 
 DD&T
 
 Volume: 9 Issue: 3 Pages: 184-190
- DOI
 10.5582/ddt.2015.01036
- NAID
 130005088580
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-26460062
[Journal Article] Isolation of mammalian pathogenic bacteria using silkworms2015
- Author(s)
  Kaito C., Usui, K., Kyuma, T., and Sekimizu K
- Journal Title
  
  DD&T
  
  Volume: 5 Issue: 2 Pages: 66-70
- DOI
  10.5582/ddt.2011.v5.2.66
- NAID
  130005054696
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2015-02-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009
[Journal Article] Lysocin E is a novel antibiotic that targets menaquinone in the bacterial membrane.2015
- Author(s)
  Hamamoto H, Urai M, Ishii K, Yasukawa J, Paudel A, Murai M, Kaji T, Kuranaga T, Hamase K, Katsu T, Su J, Adachi T, Uchida R, Tomoda H, Yamada M, Souma M, Kurihara H, Inoue M, Sekimizu K.
- Journal Title
  
  Nature Chem. Biol.
  
  Volume: 11(2) Pages: 127-133
- DOI
  10.1038/nchembio.1710
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J11042, KAKENHI-PROJECT-13F03093, KAKENHI-PROJECT-24689008, KAKENHI-PROJECT-25460036, KAKENHI-PUBLICLY-26102714, KAKENHI-PROJECT-26253003, KAKENHI-PROJECT-26670396, KAKENHI-PROJECT-24249047
[Journal Article] Current use of silkworm larvae (Bombyx mori) as an animal model in pharmaco-medical research2015
- Author(s)
 Nwibo DD, Hamamoto H, Matsumoto Y, Kaito C, Sekimizu K.
- Journal Title
 
 DD&T
 
 Volume: 9 Issue: 2 Pages: 133-135
- DOI
 10.5582/ddt.2015.01026
- NAID
 130005071480
- ISSN
 1881-7831, 1881-784X
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-26460062
[Journal Article] Primed Immune Responses Triggered by Ingested Bacteria Lead to Systemic Infection Tolerance in Silkworms2015
- Author(s)
  Miyashita, A. Takahashi, S. Ishii, K. Sekimizu, K. Kaito, C.
- Journal Title
  
  PloS one
  
  Volume: 10
- DOI
  10.1371/journal.pone.0130486
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H05783, KAKENHI-PROJECT-13J08664, KAKENHI-PROJECT-26670025
[Journal Article] Establishment of transgenic silkworms expressing GAL4 specifically in hemocytes2014
- Author(s)
  Tsubota T, Uchino K, Kamimura M, Ishikawa M, Hamamoto H, Sekimizu K, Sezutsu H.
- Journal Title
  
  Insect Molecular Biology
  
  Volume: 23(2) Pages: 165-174
- DOI
  10.1111/imb.12071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-25292202
[Journal Article] CvfA and PNPase act in an opposing manner to regulate Staphylococcus aureus virulence.2014
- Author(s)
  Numata S, Nagata M, Mao H, Sekimizu K, Kaito C
- Journal Title
  
  J Biol Chem.
  
  Volume: 289 Pages: 8420-31
- DOI
  10.1074/jbc.m114.554329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-24590519, KAKENHI-PUBLICLY-25117507
[Journal Article] Establishment of a bacterial infection model using the European honeybee, Apis mellifera L2014
- Author(s)
  Ishii K, Hamamoto H, Sekimizu K.
- Journal Title
  
  PLoS One
  
  Volume: 24;9(2)
- DOI
  10.1371/journal.pone.0089917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009, KAKENHI-PUBLICLY-24102510, KAKENHI-PROJECT-24689008
[Journal Article] Transgenic silkworms expressing human insulin receptors for evaluation of therapeutically active insulin receptor agonists.2014
- Author(s)
  Matsumoto Y, Ishii M, Ishii K, Miyaguchi W, Horie R, Inagaki Y, Hamamoto H, Tatematsu K, Uchino K, Tamura T, Sezutsu H, Sekimizu K.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 455(3-4) Pages: 159-164
- DOI
  10.1016/j.bbrc.2014.10.143
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-12J11042, KAKENHI-PROJECT-26460062
[Journal Article] カイコを用いた創薬研究2014
- Author(s)
  松本靖彦、浜本洋、西田智、関水和久
- Journal Title
  
  生体の科学
  
  Volume: 65 Pages: 613-620
- NAID
  40020290149
- Data Source
  KAKENHI-PROJECT-26460062
[Journal Article] Identification of a Serratia marcescens virulence factor that promotes hemolymph bleeding in the silkworm, Bombyx mori2014
- Author(s)
  Ishii K, Adachi T, Hara T, Hamamoto H, Sekimizu K.
- Journal Title
  
  Journal of invertebrate pathology
  
  Volume: 117 Pages: 61-67
- DOI
  10.1016/j.jip.2014.02.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J11042, KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-24689008
[Journal Article] Impact of psm-mec in the Mobile Genetic Element on the Clinical Characteristics and Outcome of SCCmec-II Methicillin-resistant Staphylococcus aureus Bacteremia in Japan2014
- Author(s)
  Aoyagi T, Kaito C, Sekimizu K, Omae Y, Saito Y, Mao H, Inomata S, Hatta M, Endo S, Kanamori H, Gu Y, Tokuda K, Yano H, Kitagawa M, Kaku M
- Journal Title
  
  C1in Microbio1 Infect
  
  Volume: (in press)
- DOI
  10.1111/1469-0691.12575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-23791131, KAKENHI-PROJECT-24590519, KAKENHI-PUBLICLY-25117507
[Journal Article] Primed immune response to Gram-negative peptodoglycans confer infection resistance in silkworms2014
- Author(s)
  Miyashita A, Kizaki H, Kawasaki K, Sekimizu K, Kaito C
- Journal Title
  
  J Biol Chem.
  
  Volume: 289 Pages: 14412-14421
- DOI
  10.1074/jbc.m113.525139
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J08664, KAKENHI-PROJECT-23249009, KAKENHI-PUBLICLY-25117507
[Journal Article] Niemann-Pick disease type C2 protein induces triglyceride accumulation in silkworm and mammalian cell lines.2014
- Author(s)
  Adachi T, Ishii K, Matsumoto Y, Hayashi Y, Hamamoto H, Sekimizu K.
- Journal Title
  
  Biochem J.
  
  Volume: 459(1) Pages: 137-147
- DOI
  10.1042/bj20130876
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J10784, KAKENHI-PROJECT-12J11042, KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-26460062
[Journal Article] Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli2014
- Author(s)
  Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, Kaneki K, Inoue T, Kobayashi M, Kodama T, Wada Y, Sekimizu K and Akimitsu N.
- Journal Title
  
  Mol. Cell
  
  Volume: 53 Pages: 393-406
- DOI
  10.1016/j.molcel.2014.01.009
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-12J08481, KAKENHI-PROJECT-12J10632, KAKENHI-PROJECT-14J11190, KAKENHI-PROJECT-23249009, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115002, KAKENHI-PUBLICLY-24115706, KAKENHI-PROJECT-24790434, KAKENHI-PROJECT-24890029, KAKENHI-PUBLICLY-25115506, KAKENHI-PUBLICLY-25118505, KAKENHI-PROJECT-25291001, KAKENHI-PROJECT-25640112, KAKENHI-PROJECT-25670619, KAKENHI-PROJECT-26460548, KAKENHI-PROJECT-26860299, KAKENHI-PROJECT-221S0002, KAKENHI-PROJECT-22228005, KAKENHI-PROJECT-26220805
[Journal Article] 高血糖カイコを用いた糖尿病の基礎研究と創薬展開2014
- Author(s)
  松本靖彦、関水和久
- Journal Title
  
  生化学
  
  Volume: 86 Pages: 613-619
- Data Source
  KAKENHI-PROJECT-26460062
[Journal Article] Use of silkworms to evaluate the pathogenicity of bacteria attached to cedar pollen2014
- Author(s)
  Hu Y, Hamamoto H, Sekimizu K.
- Journal Title
  
  DD&T
  
  Volume: 7(4) Issue: 4 Pages: 153-157
- DOI
  10.5582/ddt.2013.v7.4.153
- NAID
  130005054772
- ISSN
  1881-7831, 1881-784X
- Year and Date
  2014-06-13
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-24659041
[Journal Article] Antimicrobial action mechanism of flavonoids from Dorstenia species2014
- Author(s)
 Dzoyem JP, Hamamoto H, Ngameni B, Ngadjui BT, Sekimizu K
- Journal Title
 
 DD&T
 
 Volume: 7 Issue: 2 Pages: 153-157
- DOI
 10.5582/ddt.2013.v7.2.66
- NAID
 130004588093
- ISSN
 1881-7831, 1881-784X
- Year and Date
 2014-06-13
- Language
 English
- Peer Reviewed
- Data Source
 KAKENHI-PUBLICLY-24102510, KAKENHI-PROJECT-24659041, KAKENHI-PROJECT-24689008
[Journal Article] Evaluation of the hyperglycemic effects of the herbal medicine Rehmanniae Radix using a hyperglycemic silkworm model2014
- Author(s)
  Matsumoto Y, Sekimizu K
- Journal Title
  
  AATEX
  
  Volume: 19 Pages: 1-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460062
[Journal Article] Serratia marcescens suppresses host cellular immunity via the production of an adhesion-inhibitory factor against immunosurveillance cells2014
- Author(s)
  Ishii K, Adachi T, Hamarrioto H, Sekimizu K.
- Journal Title
  
  J Biol Chem
  
  Volume: 289(9) Pages: 5876-5888
- DOI
  10.1074/jbc.m113.544536
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J10784, KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-24689008
[Journal Article] Structure-activity relationship study of novel iminothiadiazolo-pyrimidinone antimicrobial agents2013
- Author(s)
  Paudel A, Kaneko K, Watanabe A, Shigeki M, Motomu K, Hamamoto H, Sekimizu K
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 66 Pages: 663-667
- DOI
  10.1038/ja.2011.110
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24102510
[Journal Article] Mobile Genetic Element SCCmec-encoded psm-mec RNA Suppresses Translation of agrA and Attenuates MRSA Virulence.2013
- Author(s)
  垣内力、斎藤祐樹、幾尾真理子、藤幸知子、沼田俊介、韓笑、小幡佳津明、長谷川節雄、山口博樹、猪口孝一、伊藤輝代、平松啓一、関水和久
- Journal Title
  
  PLoS Pathog.
  
  Volume: 9
- DOI
  10.1371/journal.ppat.1003269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J11061, KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-23890038, KAKENHI-PROJECT-24590519, KAKENHI-PUBLICLY-25117507
[Journal Article] Silkworm apolipophorin protein inhibits hemolysin gene expression of Staphylococcus aureus via binding to cell surface lipoteichoic acids.2013
- Author(s)
  Omae Y, Hanada Y, Sekimizu K, Kaito C
- Journal Title
  
  J Biol Chem.
  
  Volume: 288 Pages: 25542-50
- DOI
  10.1074/jbc.m113.495051
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-24590519, KAKENHI-PUBLICLY-25117507
[Journal Article] Structure-activity relationship study of novel iminothiadiazolo-pyrimidinone antimicrobial agents2013
- Author(s)
  Paudel A, Kaneko K, Watanabe A, Shigeki M, Motomu K, Hamamoto H, Sekimizu K.
- Journal Title
  
  J Antibiot (Tokyo)
  
  Volume: 66(11) Pages: 663-667
- DOI
  10.1038/ja.2013.69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05013, KAKENHI-PROJECT-13F03093, KAKENHI-PROJECT-24659041, KAKENHI-PROJECT-24689008
[Journal Article] Inhibition of colony-spreading activity of Staphylococcus aureus by secretion of δ-hemolysin.2012
- Author(s)
  Yosuke Omae, Kazuhisa Sekimizu, Chikara Kaito
- Journal Title
  
  J Biol Chem.
  
  Volume: (In press) Pages: 15570-15579
- DOI
  10.1074/jbc.m112.357848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J11070, KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-24590519
[Journal Article] Evaluation of Staphylococcus aureus virulence factors using a silkworm model2012
- Author(s)
  Miyazaki, S., Matsumoto, Y., Sekimizu K., and Kaito C
- Journal Title
  
  FEMS Microbiol Lett
  
  Volume: 326 Pages: 116-124
- DOI
  10.1111/j.1574-6968.2011.02439.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-24790069
[Journal Article] Inhibition of colony-spreading activity of Staphylococcus aureus by secretion of delta-hemolysin2012
- Author(s)
  Omae Y, Sekimizu K, Kaito C
- Journal Title
  
  J Biol Chem.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009
[Journal Article] Quantitative evaluation of cryptococcal pathogenesis and antifungal drugs using a silkworm infection model with Cryptococcus neoformans2012
- Author(s)
  Matsumoto Y, Miyazaki S, Fukunaga DH, Shimizu K, Kawamoto S, Sekimizu K
- Journal Title
  
  J Appl Microbiol
  
  Volume: 112 Pages: 138-46
- DOI
  10.1111/j.1365-2672.2011.05186.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-24790069
[Journal Article] Lipopolysaccharide O-antigen of enterohemorrhagic Escherichia coli 0157 : H7 is required for killing both insects and mammals2012
- Author(s)
  Atsushi Miyashita, et al.
- Journal Title
  
  FEMS Microbiol Lett.
  
  Volume: 333 Pages: 59-68
- DOI
  10.1111/j.1574-6968.2012.02599.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J11042, KAKENHI-PROJECT-23249009, KAKENHI-PROJECT-23590528, KAKENHI-PROJECT-24590519, KAKENHI-PROJECT-24689008
[Journal Article] Purification of innate immunostimulant from green tea using a silkworm muscle contraction assay.2011
- Author(s)
  Dhital S, Hamamoto H, Urai M, Ishii K, Sekimizu K
- Journal Title
  
  Drug Discoveries & Therapeutics.
  
  Volume: 5 Pages: 18-25
- NAID
  130005054690
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Transcription and Translation Products of the Cytolysin Gene psm-mec on the Mobile Genetic Element SCCmec Regulate Staphylococcus a ureus Virulence.2011
- Author(s)
  Kaito C, Saito Y, Nagano G, Ikuo M, Omae Y, Hanada Y, Han X, Kuwahara-Arai K, Hishinuma T, Baba T, Ito T, Hiram atsu K, Sekimizu K.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 3;7(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Sugar-responsive gene expression and the agr system are required for colony spreading in Staphylococcus aureus2011
- Author(s)
  Tomofumi Ueda, Chikara Kaito, Yosuke Omae, Kazuhisa Sekimizu
- Journal Title
  
  Microbial pathogenesis
  
  Volume: 51 Pages: 178-185
- DOI
  10.1016/j.micpath.2011.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J11070, KAKENHI-PROJECT-23249009
[Journal Article] Purification of innate immunostimulant from green tea using a silkworm muscle contraction assay.2011
- Author(s)
  Dhital S, Hamamoto H, Urai M, Ishii K, Sekimizu K.
- Journal Title
  
  Drug Discoveries & Therapeutics.
  
  Volume: 5 Pages: 18-25
- NAID
  130005054690
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] An Invertebrate Hyperglycemic Model for the Identification of Anti-Diabetic Drugs.2011
- Author(s)
  Matsumoto Y, Sumiya E, Sugita T, Sekimizu K.
- Journal Title
  
  PLoS one
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence2011
- Author(s)
  Kaito C., Saito, Y., Nagano, G., Ikuo, M., Omae, Y., Hanada, Y., Han, X., Kuwahara-Arai, K., Hishinuma, T., Baba, T., Ito, T., Hiramatsu, K., and Sekimizu K
- Journal Title
  
  PLoS Pathog
  
  Volume: 7
- DOI
  10.1371/journal.ppat.1001267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009
[Journal Article] Sugar-responsive gene expression and the agr system are required for colony spreading in Staphylococcus aureus2011
- Author(s)
  Ueda T, Kaito C, Omae Y, Sekimizu K
- Journal Title
  
  Microb Pathog.
  
  Volume: 51 Pages: 178-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009
[Journal Article] Digestion of extracellular DNA is required for giant colony formation of Staphylococcus aureus2011
- Author(s)
  Chikara Kaito, Takanori Hirano, Yosuke Omae, Kazuhisa Sekimizu
- Journal Title
  
  Microbial pathogenesis
  
  Volume: 51 Pages: 142-148
- DOI
  10.1016/j.micpath.2011.04.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J11070, KAKENHI-PROJECT-23249009
[Journal Article] An invertebrate hyperglycemic model for the identification of anti-diabetic drugs2011
- Author(s)
  Matsumoto Y, Sumiya E, Sugita T, Sekimizu K
- Journal Title
  
  PLoS One.
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009
[Journal Article] Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence.2011
- Author(s)
  Kaito C, Saito Y, Nagano G, Ikuo M, Omae Y, Hanada Y, Han X, Kuwahara-Arai K, Hishinuma T, Baba T, Ito T, Hiramatsu K, Sekimizu K.
- Journal Title
  
  PLoS Pathog. 7(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Digestion of extracellular DNA is required for giant colony formation of Staphylococcus aureus2011
- Author(s)
  Kaito C, Hirano T, Omae Y, Sekimizu K
- Journal Title
  
  Microb Pathog
  
  Volume: 51 Pages: 142-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009
[Journal Article] Transcription and Translation Products of the Cytolysin Gene psm-mec on the Mobile Genetic Element SCCmec Regulate Staphylococcus aureus Virulence.2011
- Author(s)
  Kaito C, Saito Y, Nagano G, Ikuo M, Omae Y, Hanada Y, Han X, Kuwahara-Arai K, Hishinuma T, Baba T, Ito T, Hiramatsu K, Sekimizu K.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 3;7(2)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Intestinal resident yeast Candida glabrata requires Cyb2p-mediated lactate assimilation to adapt in mouse intestine2011
- Author(s)
  Ueno K, Matsumoto Y, Uno J, Sasamoto K, Sekimizu K, Kinjo Y, Chibana H
- Journal Title
  
  PLoS One.
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009
[Journal Article] Silkworm apolipophorin protein inhibits Staphylococcus aureus virulence2011
- Author(s)
  Hanada, Y., Sekimizu K., and Kaito C
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 39360-39369
- DOI
  10.1074/jbc.m111.278416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009
[Journal Article] Silkworm apolipophorin protein inhibits Staphylococcus aureus virulence2011
- Author(s)
  Hanada Y, Sekimizu K, Kaito C
- Journal Title
  
  J Biol Chem.
  
  Volume: 286 Pages: 39360-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009
[Journal Article] Isolation of mammalian pathogenic bacteria using silkworms2011
- Author(s)
  Kaito C, Usui K, Kyuma T, Sekimizu K
- Journal Title
  
  Drug Discov Ther.
  
  Volume: 5 Pages: 66-70
- NAID
  130005054696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249009
[Journal Article] The cvfC operon of Staphylococcus aureus contributes to virulence via expression of the thyA gene.2010
- Author(s)
  Ikuo M, Kaito C, Sekimizu K.
- Journal Title
  
  Microb Pathog. 49(1-2)(Epub 2010 Mar 27)
  
  Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Inhibitory role for D-alanylation of wall teichoic acid in activation of insect Toll pathway by peptidoglycan of Staphylococcus aureus.2010
- Author(s)
  Tabuchi Y, Shiratsuchi A, Kurokawa K, Gong JH, Sekimizu K, Lee BL, Nakanishi Y.
- Journal Title
  
  J Immunol.
  
  Volume: 15;185(4) Pages: 2424-31
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Use of silkworms for identification of drug candidates having appropriate pharmacokinetics from plant sources2010
- Author(s)
  Asami Y, Horie R, Hamamoto H, Sekimizu K
- Journal Title
  
  BMC Pharmacology
  
  Volume: 10 Pages: 7-7
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Shuttle vectors derived from pN315 for study of essential genes in Staphylococcus aureus2010
- Author(s)
  Matsuo M, Kurokawa K, Lee B L, Sekimizu K
- Journal Title
  
  Biol Pharm Bull 33
  
  Pages: 198-203
- NAID
  130000156624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] The cvfC operon of Staphylococcus aureus contributes to virulence via expression of the thyA gene2010
- Author(s)
  Ikuo M, Kaito C, Sekimizu K
- Journal Title
  
  Microb Pathog (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Structure of a virulence regulatory factor CvfB reveals a novel winged-helix RNA binding module2010
- Author(s)
  Matsumoto Y, Xu Q, Kaito C, Farr C L, Axelrod H L, Chiu H-J, Klock H E, Knuth M W, Miller M D, Elsliger M-A, Deacon A M, Godzik A, Lesley S A, Sekimizu K, Wilson I A
- Journal Title
  
  Structure
  
  Volume: 18(4) Pages: 537-547
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Structure of a virulence regulatory factor CvfB reveals a novel winged-helix RNA binding module2010
- Author(s)
  Matsumoto Y, Xu Q, Kaito C, Farr C L, Axelrod H L, Chiu H-J, Klock H E, Knuth M W, Miller M D, Elsliger M-A, Deacon A M, Godzik A, Lesly S A, Sekimizu K, Wilsom I A
- Journal Title
  
  Structur (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Evaluation of therapeutic effects and pharmacokinetics of antibacterial chromogenic agents in silkworm model of Staphylococcus aureus infection2010
- Author(s)
  Fujiyuki T, Imamura K, Harnamoto H, Sekimizu K.
- Journal Title
  
  Drug Dicoveries and Therapeutics
  
  Volume: 14(5) Pages: 349-354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Porphyromonas gingivalis peptidoglycans induce excessive activation of the innate immune system in silkworm larvae.2010
- Author(s)
  Ishii K, Hamamoto H, Imamura K,Adachi T, Shoji M, Nakayama K, Sekimizu K.
- Journal Title
  
  J Biol Chem.
  
  Volume: 285(43) Pages: 33338-33347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Novel RNA polymerase II mutation suppresses transcriptional fidelity and oxidative stress sensitivity in rpb9Delta yeast2010
- Author(s)
  Koyama H, Ueda T, Ito T, Sekimizu K
- Journal Title
  
  Genes Cells 15
  
  Pages: 151-159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Cell-permeable carboxy-terminal p27Kipl peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase2010
- Author(s)
  Morishita D, Takami M, Yoshikawa S, Katayama Ryohei, Sato S, Kukimoto-Niino M, Umeh ara T, Shirouzu M, Sekimizu K, Yokoyama S, Fujita N
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Pages: 2681-2688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Porphyromonas gingivalis peptidoglycans induce excessive activation of the innate immune system in silkworm larvae.2010
- Author(s)
  Ishii K, Hamamoto H, Imamura K, Adachi T, Shoji M, Nakayama K, Sekimizu K.
- Journal Title
  
  J Biol Chem. 285(43)
  
  Pages: 33338-33347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] An Invertebrate Hyperglycemic Model for the Identification of Anti-D iabetic Drugs.2010
- Author(s)
  Matsumoto Y, Sumiya E, Sugita T, Sekimizu K.
- Journal Title
  
  PLoS one
  
  Volume: (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Shuttle vectors derived from pN315 for study of essential genes in Staphylococcus aureus2010
- Author(s)
  Matsuo M, Kurokawa K, Lee BL, Sekimizu K.
- Journal Title
  
  Biol.Pharm. Bull.
  
  Volume: 33(2) Pages: 198-203
- NAID
  130000156624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Cell-permeable carboxy-terminal p27Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase2010
- Author(s)
  Morishita D, Takami M, Yoshikawa S, Katayama Ryohei, Sato S, Kukimoto-Niino M, Umehara T, Shirouzu M, Sekimizu K, Yokoyama S, Fujita N
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 286 Pages: 2681-2688
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Structure of a virulence regulatory factor CvfB reveals a novel winged-helix RNA binding module2010
- Author(s)
  Matsumoto Y, Xu Q, Kaito C, Farr CL, Axelrod HL, Chiu H-J, Klock HE, Knuth MW, Miller MD, Elsliger M-A, Deacon AM, Godzik A, Lesly SA, Sekimizu K, Wilsom IA
- Journal Title
  
  Structur (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] The cvfC operon of Staphylococcus aureus contributes to virulence via expression of the thyA gene2010
- Author(s)
  Ikuo M, Kaito C, Sekimizu K
- Journal Title
  
  Microb Pathog (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Shuttle vectors derived from pN315 for study of essential genes in Staphylococcus aureus2010
- Author(s)
  Matsuo M, Kurokawa K, Lee BL, Sekimizu K.
- Journal Title
  
  Biol.Pharm.Bull.
  
  Volume: 33(2) Pages: 198-203
- NAID
  130000156624
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] The cvfC operon of Staphylococcus aureus contributes to virulence via the expression of the thvA gene2010
- Author(s)
  Ikuo M, Kaito C, Sekimizu K
- Journal Title
  
  Microbial Pathogenesis
  
  Volume: 49(1-2) Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Novel RNA polymerase II mutation suppresses transcriptional fidelity and oxidative stress sensitivity in rpb9Delta yeast2010
- Author(s)
  Koyama H, Ueda T, Ito T, Sekimizu K
- Journal Title
  
  Genes Cells 15
  
  Pages: 151-159
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Porphyromonas gingivalis peptidoglycans induce excessive activation of the innate immune system in silkworm larvae.2010
- Author(s)
  Ishii K, Hamamoto H, Imamura K, Adachi T, Shoji M, Nakayama K, Sekimizu K.
- Journal Title
  
  J Biol Chem.
  
  Volume: 285(43) Pages: 33338-33347
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module.2010
- Author(s)
  Matsumoto Y, Xu Q, Miyazaki S, Kaito C, Farr CL, Axelrod HL, Chiu HJ, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Sekimizu K, Wilson IA.
- Journal Title
  
  Structure. 18(4)
  
  Pages: 537-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Use of silkworms for identification of drug candidates having appropriate Pharmacokinetics from plant sources2010
- Author(s)
  Asami Y, Horie R, Hamamoto H, Sekimizu K
- Journal Title
  
  BMC Pharmacology
  
  Volume: 10 Pages: 7-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Structure of a virulence regulatory factor CvfB reveals a novel winge d-helix RNA binding module2010
- Author(s)
  Matsumoto Y, Xu Q, Kaito C, Fan C L, Axelrod H L, Chiu H-J, Klock H E, Knuth M W, Miller M D, Elsliger M-A, Deacon A M, Godzik A, Lesley S A, Sekimizu K, Wilson I A
- Journal Title
  
  Structure
  
  Volume: 18(4) Pages: 537-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Insect cytokine paralytic peptide (PP) induces cellular and humoral immune responses in the silkworm Bombyx mori.2010
- Author(s)
  Ishii K, Hamamoto H, Kamimura M, Nakamura Y, Noda H, Imamura K, Mita K, Sekimizu K.
- Journal Title
  
  J Biol Chem. 285(37)
  
  Pages: 28635-28642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Shuttle vectors derived from pN315 for study of essential genes in Staphylococcus aureus2010
- Author(s)
  Matsuo M, Kurokawa K, Lee BL, Sekimizu K
- Journal Title
  
  Biol Pharm Bull 33
  
  Pages: 198-203
- NAID
  130000156624
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] The insect cytokine, paralytic peptide(PP) induces cellular and humoral immune responses in the silkworm Bombyx mori.2010
- Author(s)
  Ishii K, Hamamoto H, Kamimura M, Nakamura Y, Noda H, Imamura K, Mita K, Sekimizu K.
- Journal Title
  
  J Biol Chem.
  
  Volume: 285(37) Pages: 28635-28642
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Inhibitory role for D-alanylation of wall teichoic acid in activation of insect Toll pathway by peptidoglycan of Staphylococcus aureus.2010
- Author(s)
  Tabuchi Y, Shiratsuchi A, Kurokawa K, Gong JH, Sekimizu K, Lee BL, Nakanishi Y.
- Journal Title
  
  J Immunol.
  
  Volume: 15;185(4) Pages: 2424-2431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] The cvfC operon of Staphylococcus aureus contributes to virulence via the expression of the thyA gene2010
- Author(s)
  Ikuo M, Kaito C, Sekimizu K
- Journal Title
  
  Microbial Pathogenesis
  
  Volume: 49(1-2) Pages: 1-7
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] The insect cytokine, paralytic peptide(PP) induces cellular and humora 1 immune responses in the silkworm Bombyx mori.2010
- Author(s)
  Ishii K, Hamamoto H, Kamimura M, Nakamura Y, Noda H, Imamura K, Mita K, Sekimizu K.
- Journal Title
  
  J Biol Chem.
  
  Volume: 285(37) Pages: 28635-28642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Evaluation of therapeutic effects and pharmacokinetics of antibacterial chromogenic agents in silkworm model of Staphylococcus aureus infection2010
- Author(s)
  Fujiyuki T, Imamura K, Hamamoto H, Sekimizu K.
- Journal Title
  
  Drug Dicoveries and Therapeutics
  
  Volume: 4(5) Pages: 349-354
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Apoptosis-inducingactivity of compounds screened andcharacterized from cinobufacini bybioassay-guided isolation2010
- Author(s)
  Wang DL, Qi FH, Xu HL, Inagaki Y, Orihara Y, Sekimizu K, Kokudo N, Wang FS, Tang W.
- Journal Title
  
  Mol Med Rep
  
  Volume: 3(4) Pages: 717-722
- DOI
  10.3892/mmr_00000323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390373
[Journal Article] Purification of a soil bacteria exotoxin using silkworm toxicity to measure specific activity2009
- Author(s)
  Usui K, Miyazaki S, Kaito C, Sekimizu K.
- Journal Title
  
  Microbial Pathogenesis 46
  
  Pages: 59-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041022
[Journal Article] Evaluation of target specificity of antibacterial agents using Staphylococcus aureus dd1A mutants and D-cycloserine in a silkworm infection model2009
- Author(s)
  Kurokawa K, Hamamoto H, Matsuo M, Nishida S, Yamane N, Lee B L, Murakami K, Maki H, Sekimizu K
- Journal Title
  
  Antimicrob Agents Chemother 53
  
  Pages: 4025-4027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Prevention of death in bacterium-infected mice by a synthetic antimicrobial peptide, L5, through activation of host immunity2009
- Author(s)
  Okuyama-Nishida Y, Akiyama N, Sugimori G, Nomura K, Ogawa K, Homma K J, Sekimizu K, Tsujimoto M, Natori S
- Journal Title
  
  Antimicrob Agents Chemother 53
  
  Pages: 2510-2516
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Auxiliary role for d-alanylated wall teichoic acid in Toll-like receptor 2-mediated survival of Staphylococcus aureus in macrophages2009
- Author(s)
  Shiratsuchi A, Shimizu K, Watanabe I, Hashimoto Y, Kurokawa K, Razanajatovo IM, Park KH, Park HK, Lee BL, Sekimizu K, Nakanishi Y
- Journal Title
  
  Immunology (In press)
- NAID
  120001828365
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Rapid exchange of bound ADP on the Staphylococcus aureus replication initiation protein DnaA2009
- Author(s)
  Kurokawa K, Mizumura H, Takaki T, Ishii Y, Ichihashi N, Lee B L, Sekimizu K
- Journal Title
  
  J Blol Chem 284
  
  Pages: 34201-34210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Silkworm as a model animal to evaluate drug candidate toxicity and metabolism2009
- Author(s)
  Hamamoto H, Tonoike A, Narushima K, Horie R, Sekimizu K
- Journal Title
  
  Comp Biochem Physiol C Toxicol Pharmacol 149
  
  Pages: 334-339
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Silkworm as a model animal to evaluate drug candidate toxicity and metabolism2009
- Author(s)
  Hamamoto H, Tonoike A, Narushima K, Horie R, Sekimizu K
- Journal Title
  
  Comp Biochem Physiol C Toxicol Pharmacol 149
  
  Pages: 334-339
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model2009
- Author(s)
  Kurokawa K, Hamamoto H, Matsuo M, Nishida S, Yamane N, Lee BL, Murakami K, Maki H, Sekimizu K
- Journal Title
  
  Antimicrob Agents Chemother 53
  
  Pages: 4025-4027
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Rapid exchange of bound ADP on the Staphylococcus aureus replication initiation protein DnaA2009
- Author(s)
  Kurokawa K, Mizumura H, Takaki T, Ishii Y, Ichihashi N, Lee BL, Sekimizu K
- Journal Title
  
  J Biol Chew 284
  
  Pages: 34201-34210
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Distribution of Kakugo virus and its effects on the gene expression profile in the brain of the worker honeybee Apis mellifera L2009
- Author(s)
  Fujiyuki T, Matsuzaka E, Nakaoka T, Takeuchi H, Wakamo to A, Ohka S, Sekimizu K, Nomoto A, Kubo T
- Journal Title
  
  J Virol 83
  
  Pages: 11560-11568
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Identification of lipoteichoic acid as a ligand for draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes2009
- Author(s)
  Hashimoto Y, Tabuchi Y, Sakurai K, Kutsuna M, Kurokawa K, Awasaki T, Sekimizu K, Nakanishi Y, Shiratsuchi A
- Journal Title
  
  J Immunol 183
  
  Pages: 7451-7460
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Auxiliary role for d-alanylated wall teichoic acid in Toll-like receptor 2-mediated survival of Staphylococcus aureus in macrophages2009
- Author(s)
  Shiratsuchi A, Shimizu K, Watanabe I, Hashimoto Y, Kurokawa K, Razanajatovo I M, Park K H, Park H K, Lee B L, Sekimizu K, Nakanishi Y
- Journal Title
  
  Immunology (in press)
- NAID
  120001828365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Rapid exchange of bound ADP on the Staphylococcus aureus replication initiation protein DnaA.2009
- Author(s)
  Kurokawa K, Mizumura H, Takaki T, Ishii Y, Ichihashi N, Lee BL, Sekimizu K.
- Journal Title
  
  J Biol Chem. 284(49)
  
  Pages: 34201-34210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Prevention of death in bacterium-infected mice by a synthetic antimicrobial peptide, L5, through activation of host immunity2009
- Author(s)
  Okuyama-Nishida Y, Akiyama N, Sugimori G, Nomura K, Ogawa K, Homma KJ, Sekimizu K, Tsujimoto M, Natori S
- Journal Title
  
  Antimicrob Agents Chemother 53
  
  Pages: 2510-2516
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Distribution of Kakugo virus and its effects on the gene expression profile in the brain of the worker honeybee Apis mellifera L2009
- Author(s)
  Fujiyuki T, Matsuzaka E, Nakaoka T, Takeuchi H, Wakamoto A, Ohka S, Sekimizu K, Nomoto A, Kubo T
- Journal Title
  
  J Virol 83
  
  Pages: 11560-11568
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21022015
[Journal Article] Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model.2009
- Author(s)
  Kurokawa K, Hamamoto H, Matsuo M, Nishida S, Yamane N, Lee BL, Murakami K, Maki H, Sekimizu K.
- Journal Title
  
  Antimicrob Agents Chemother. 53(9)
  
  Pages: 4025-4027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Purification of a soil bacteria exotoxin using silkworm toxicity to measure specific activity.2009
- Author(s)
  Usui K, Miyazaki S, Kait o C, Sekimizu K.
- Journal Title
  
  Microbial Pathogenesis 46
  
  Pages: 59-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Identification of lipoteichoic acid as a ligand for draper in the phagocytosis of Staphylococcus aureus by Drosophila hemocytes2009
- Author(s)
  Hashimoto Y, Tabuchi Y, Sakurai K, Kutsuna M, Kurokawa K, Awasaki T, Sekimizu K, Nakanishi Y, Shiratsuchi A
- Journal Title
  
  J Immunol 183
  
  Pages: 7451-7460
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Pleiotropic roles of polyglycerolphosphate synthase of lipoteichoic acid in growth of Staphylococcus aureus cells.2009
- Author(s)
  Oku Y, Kurokawa K, Matsuo M, Yamada S, Lee BL, Sekimizu K.
- Journal Title
  
  J Bacteriol. 191(1)
  
  Pages: 141-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Purification of a soil bacteria exotoxin using silkworm toxicity to measure specific activity.2009
- Author(s)
  Usui K, Miyazaki S, Kaito C, Sekimizu K.
- Journal Title
  
  Microb Pathog. 46(2)
  
  Pages: 59-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] A novel gene, fudoh, in the SCCmec region suppresses the colony spreading ability and virulence of Staphylococcus aureus.2008
- Author(s)
  Kaito C, Omae Y, Matsumoto Y, Nagata M, Yamaguchi H, Aoto T, Ito T, Hiramatsu K, Sekimizu K.
- Journal Title
  
  PLoS One. 3(12)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Pleiotropic roles of polyglycerolphosphate synthase of lipoteichoic acid in growth of Staphylococcus aureus cells2008
- Author(s)
  Oku Y, Kurokawa K, Matsuo M, Yamada S, Lee BL, Sekimizu K.
- Journal Title
  
  J. Bacteriol. 191
  
  Pages: 141-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041022
[Journal Article] A novel gene, fudoh, in the SCCmec region suppresses the colony spreading ability and virulence of Staphylococcus aureus2008
- Author(s)
  Kaito C, Omae Y, Matsumoto Y, Nagata M, Yamaguchi H, Aoto T, Ito T, Hiramatsu K, Sekimizu K.
- Journal Title
  
  PLoS ONE 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041022
[Journal Article] A novel gene, fudoh, in the SCCmec region suppresses the colony spreading ability and virulence of Staphylococcus aureus.2008
- Author(s)
  Kaito C, Omae Y, Matsumo to Y, Nagata M, Yamaguchi H, Aoto T, Ito T, Hira matsu K. Sekimizu K.
- Journal Title
  
  PLoS ONE 3
  
  Pages: 3921-3921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390021
[Journal Article] Phosphodiesterase activity of CvfA is required for virulence in Staphy lococcus aureus .2008
- Author(s)
  Nagata M, Kaito C, Sekimizu K
- Journal Title
  
  J Biol Chem. 283
  
  Pages: 2176-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041022
[Journal Article] Cloning and Expression of a Novel Sulfotransferase with Unique Substrate Specificity from Bombyx mori.2007
- Author(s)
  Hattori K, Hirayama M, Suzuki H, Hamamoto H, Sekimizu K, Tamura HO
- Journal Title
  
  Biosci Biotechnol Biochem. Apr 7(in press)
- NAID
  10027513902
- Data Source
  KAKENHI-PROJECT-17659015
[Journal Article] Colony Spreading in Staphylococcus aureus.2007
- Author(s)
  Kaito C, Sekimizu K
- Journal Title
  
  J Bacteriol 189
  
  Pages: 2553-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659016
[Journal Article] Regulation of exoprotein gene expression by the Staphylococcus aureus cvfB gene.2007
- Author(s)
  Matsumoto Y, Kaito C, Morishita D, Kurokawa K, Sekimizu K.
- Journal Title
  
  Infect Immun. Apr;75(4)
  
  Pages: 1964-1972
- Data Source
  KAKENHI-PROJECT-17659015
[Journal Article] Regulation of exoprotein gene expression by the Staphylococcus aureus cvfB gene.2007
- Author(s)
  Matsumoto Y, Kaito C, Morishita D, Kurokawa K, Sekimizu K
- Journal Title
  
  Infect Immun. 75
  
  Pages: 1964-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041022
[Journal Article] Novel DNA binding protein SarZ contributes to virulence in Staphylococcus aureus.2006
- Author(s)
  Kaito C, Morishita D, Matsumoto Y, Kurokawa K, Sekimizu K.
- Journal Title
  
  Mol Microbiol. Nov 6
  
  Pages: 1610-1617
- Data Source
  KAKENHI-PROJECT-17659015
[Journal Article] Use of silkworm larvae to study pathogenic bacterial toxins.2006
- Author(s)
  Hossain MS, Hamamoto H, Matsumoto Y, Razanajatovo IM, Larranaga J, Kaito C, Kasuga H, Sekimizu K.
- Journal Title
  
  J Biochem (Tokyo). Sep;140(3)
  
  Pages: 439-444
- NAID
  10018842490
- Data Source
  KAKENHI-PROJECT-17659015
[Journal Article] D-Glutamic acid-induced muscle contraction in the silkworm.2005
- Author(s)
  Sekimizu K, Larranaga J, Hamamoto H, a core, Furuchi T, katane M, Homma H, Matsuki N.
- Journal Title
  
  J Biochem 137
  
  Pages: 199-203
- Data Source
  KAKENHI-PROJECT-17659015
[Journal Article] Silkworm-pathogenic bacteria infection model for identification of novel virulence genes.2005
- Author(s)
  Kaito C, Kurokawa K, Matsumoto Y, Terao Y, Kawabata S, Hamada S, Sekimizu K
- Journal Title
  
  FEBS Lett 10
  
  Pages: 477-487
- Data Source
  KAKENHI-PROJECT-17659015
[Journal Article] Effects of molecular mass and hydrophobicity on transport rates through non-specific pathways of the silkworm larva midgut.2005
- Author(s)
  Hamamoto H, Kamura K, Razaria atovo I M, Murakami K, Santa T, Sekimizu K.
- Journal Title
  
  Int J Antimicrob Agents 26
  
  Pages: 38-42
- Data Source
  KAKENHI-PROJECT-17659015
[Presentation] 治療効果を指向した新規感染症治療薬の同定と開発2019
- Author(s)
  浜本洋、Suresh Panthee、石島早苗、関水和久
- Organizer
  第42回白金シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 細菌感染症研究における様々な網羅的RNA解析手法2018
- Author(s)
  浜本洋、Panthee Suresh、Paudel Atmika、鈴木穣、関水和久
- Organizer
  第91回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコを用いた新規感染症治療薬の同定と開発2018
- Author(s)
  浜本洋、Suresh Panthee、石島早苗、関水和久
- Organizer
  第101回日本細菌学会関東支部総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Silkworm model is useful for the identification of novel pathogenic genes2018
- Author(s)
  Hamamoto H、Paudel A、Panthee S、Sekimizu K
- Organizer
  18th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Candida albicans TIMM1768株の酵母系、菌糸形での発現遺伝子解析2018
- Author(s)
  石島早苗、浜本洋、山田剛、安部茂、関水和久
- Organizer
  第62回日本医真菌学会総会
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 経口抗白癬薬を評価するためのカイコ感染モデルの確立2018
- Author(s)
  松本靖彦、石井雅樹、山田剛、安部茂、関水和久
- Organizer
  第62回日本医真菌学会総会
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] In-vivo transcriptomic analysis of Staphylococcus aureus from infected organs2018
- Author(s)
  Panthee S、Hamamoto H、Paudel A、Sekimizu K
- Organizer
  18th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ感染モデルでのバンコマイシン耐性黄色ブドウ球菌に対するバンコマイシンの治療効果2018
- Author(s)
  光冨修平、浜本洋、垣内力、関水和久
- Organizer
  第30回微生物シンポジウム
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Therapeutic activity of antimicrobial agents is correlated with the appropriate pharmacokinetics in silkworms2018
- Author(s)
  Paudel A、Panthee S、Urai M、Hamamoto H、Ohwada T、Sekimizu K
- Organizer
  ASM microbe 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] ナノポアシークエンサーを用いたCandida albicans TIMM1768株の全ゲノム解析2018
- Author(s)
  浜本洋、Suresh Panthee、石島早苗、関水和久
- Organizer
  第62回日本医真菌学会総会
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Pharmacokinetics and metabolism of antibiotics in the silkworm model2018
- Author(s)
  Hamamoto H、Horie R、Panthee S、Paudel A、Sekimizu K
- Organizer
  ASM microbe 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 山椒Zanthoxylum piperitumのCandida albicans菌糸形発育抑制効果2018
- Author(s)
  羽山和美、田口裕基、関水和久、安部茂
- Organizer
  第62回日本医真菌学会総会
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 細菌感染症研究における様々な網羅的RNA解析手法2018
- Author(s)
  浜本洋、Panthee Suresh、Paudel Atmika、鈴木穣、関水和久
- Organizer
  第91回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17F17421
[Presentation] カイコ白癬菌感染モデルを用いた白癬症治療薬の評価2018
- Author(s)
  石井雅樹、松本靖彦、山田剛、安部茂、関水和久
- Organizer
  第38回関東医真菌懇話会
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Identification of novel genes required for virulence of Staphylococcus aureus USA300 using invertebrate model silkworm2018
- Author(s)
  Paudel A、Hamamoto H、Panthee S、Sekimizu K
- Organizer
  Asian Invertebrate Immunity Symposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 黄色ブドウ球菌の嫌気呼吸系発現上昇の病原性に対する寄与2017
- Author(s)
  浜本洋、扇喜秀、Panthee Suresh、Paudel Atmika、鈴木穣、関水和久
- Organizer
  2017年度生命科学学会合同年次大会 ConBio2017
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコモデルを利用した新規抗生物質ライソシンEの同定と開発2017
- Author(s)
  浜本洋、関水和久
- Organizer
  第66回日本感染症学会東日本地方会学術集会・第64回日本化学療法学会東日本支部総会合同学会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ細菌・真菌感染モデルを用いた新規抗生物質の開発2017
- Author(s)
  浜本洋、関水和久
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 黄色ブドウ球菌のマウス宿主内で発現上昇する遺伝子群の解析2017
- Author(s)
  浜本洋、扇喜秀、Panthee Suresh、Paudel Atmika, 鈴木穣、関水和久
- Organizer
  第90回日本細菌学会総会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-19
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] クリプトコックス感染症に対する抗真菌薬のカイコを用いた評価2017
- Author(s)
  松本靖彦、石井雅樹、清水公徳、川本進、関水和久
- Organizer
  真菌症フォーラム第23回学術集会
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 新規抗生物質ライソシンの開発2017
- Author(s)
  関水和久
- Organizer
  薬剤耐性(AMR)シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ細菌感染モデルにおける治療効果を指標とした抗菌薬の合成展開法の確立2017
- Author(s)
  浜本洋、Atmika Paudel、Suresh Panthee、浦井誠、大和田智彦、関水和久
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Identification and mechanistic analysis of a novel antibiotic lysocin E2016
- Author(s)
  Hiroshi Hamamoto, Kazuhisa Sekimizu
- Organizer
  The 8th Japan-Korea Chemical Biology Symposium
- Place of Presentation
  パシフィックホテル沖縄（沖縄県那覇市）
- Year and Date
  2016-01-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ感染モデルの新規抗生物質開発における有用性2016
- Author(s)
  関水和久
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 黄色ブドウ球菌のN-acetylglucosamine malate脱アセチル化酵素を介した糖尿病宿主に対する病原性発揮機構2016
- Author(s)
  石井雅樹、松本靖彦、宮崎真也、垣内力、関水和久
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪国際交流センター、大阪（大阪市）
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 熱帯性コオロギを用いたヒト病原性真菌の感染モデルの確立2016
- Author(s)
  幸地悠斗、松本靖彦、関水和久、垣内力
- Organizer
  第99回日本細菌学会関東支部会
- Place of Presentation
  北里大学、東京(港区)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 創薬へのカイコモデルの応用2016
- Author(s)
  浜本洋、関水和久
- Organizer
  昆虫デザイン研究会　家畜化過程の理解とポスト家畜化
- Place of Presentation
  岡崎コンファレンスセンター（愛知県岡崎市）
- Year and Date
  2016-07-07
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Silkworm Model for Drug Discovery and Drug Development.2016
- Author(s)
  Kazuhisa Sekimizu, Hiroshi Hamamoto
- Organizer
  The 13th Asia Pacific Federation of Pharmacologist Meeting "New Paradigms in Pharmacology for Global Health"
- Place of Presentation
  Bangkok (Thailand)
- Year and Date
  2016-02-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 無脊椎動物を用いた食後高血糖を抑制する乳酸菌の同定法の確立2016
- Author(s)
  松本靖彦、石井雅樹、関水和久
- Organizer
  第99回日本細菌学会関東支部会
- Place of Presentation
  北里大学、東京(港区)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] カイコ真菌感染モデルを利用した抗真菌薬の治療効果の評価と探索2016
- Author(s)
  浜本洋、関水和久
- Organizer
  第60回医真菌学会総会・学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-10-01
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 新規抗生物質ライソシンEの同定と作用メカニズム2016
- Author(s)
  浜本洋、関水和久
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪国際交流センター（大阪府大阪市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 黄色ブドウ球菌は、Isdヘム鉄取り込みシステムを介して糖尿病宿主環境に適応する2016
- Author(s)
  松本靖彦、宮崎真也、林陽平、石井雅樹、坂上徹、垣内力、関水和久
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪国際交流センター、大阪（大阪市）
- Year and Date
  2016-03-23
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] An Antibacterial Agent Inhibited Bacterial Transcription by Targeting the Primary Sigma Factor and Preventing Open Complex Formation2016
- Author(s)
  Atmika Paudel, Hiroshi Hamamoto, Kazuhisa Sekimizu
- Organizer
  ASM Microbe
- Place of Presentation
  Boston（MA. USA）
- Year and Date
  2016-06-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 病原性真菌の感染機構の解明のためのカイコ感染モデルの利用2016
- Author(s)
  松本靖彦、石井雅樹、関水和久
- Organizer
  第60回医真菌学会総会・学術集会
- Place of Presentation
  京王プラザホテル、東京(新宿区)
- Year and Date
  2016-10-01
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 黄色ブドウ球菌は、Isdヘム鉄取り込みシステムを介して糖尿病宿主環境に適応する2016
- Author(s)
  松本靖彦、宮崎真也、林陽平、石井雅樹、坂上徹、垣内力、関水和久
- Organizer
  第89回日本細菌学会総会
- Place of Presentation
  大阪国際交流センター（大阪府大阪市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコを用いた食後高血糖を抑制する乳酸菌の同定2016
- Author(s)
  松本靖彦、石井雅樹、関水和久
- Organizer
  第10回細菌学若手コロッセウム
- Place of Presentation
  草津セミナーハウス、群馬（吾妻郡草津町）
- Year and Date
  2016-07-31
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 病原性真菌の感染機構の解明のためのカイコ感染モデルの利用2016
- Author(s)
  松本靖彦、石井雅樹、関水和久
- Organizer
  第60回医真菌学会総会・学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-10-01
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Polyamines increase in response to hyperglycemia and protect organisms from sugar toxicity.2015
- Author(s)
  Yasuhiko Matsumoto, Kyohei Higashi, Kazuei Igarashi, and Kazuhisa Sekimizu
- Organizer
  Gordon Research Conferences -Polyamines -
- Place of Presentation
  Waterville Valley, NH, America
- Year and Date
  2015-06-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] Host factors enhance antimicrobial activity of “Lysocin E”2015
- Author(s)
  Hiroshi Hamamoto, Jie Su, Keniichi Ishii, Jyunichiro Yasukawa, Atmika Paudel, Kazuhisa Sekimizu
- Organizer
  The international chemical congress of pacific basin societies 2015 (Pacifichem 2015)
- Place of Presentation
  Honolulu (Hawaii, USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコ細菌感染モデルにて同定された新規抗生物質ライソシンE2015
- Author(s)
  浜本洋、関水和久
- Organizer
  第64回日本感染症学会東日本地方学術集会、第62回日本化学療法学会東日本支部総会　合同学会
- Place of Presentation
  ロイトン札幌（北海道札幌市）
- Year and Date
  2015-10-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] カイコの感染モデルを用いた新規感染症治療薬の発見手法2015
- Author(s)
  関水和久
- Organizer
  第27回微生物シンポジウム
- Place of Presentation
  岡山大学（岡山県岡山市）
- Year and Date
  2015-09-04
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 高度バンコマイシン耐性黄色ブドウ球菌に対してバンコマイシンとβ-ラクタム系抗生物質は相乗的に作用する2015
- Author(s)
  田渕史晃、松本靖彦、石井雅樹、松尾美記、龍野桂太、岡崎充宏、森屋恭爾、関水和久
- Organizer
  第15回東京大学生命科学シンポジウム
- Place of Presentation
  東京大学、東京（文京区）
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 黄色ブドウ球菌の病原性発現に働くヌクレオシド二リン酸分解酵素に関する研究2015
- Author(s)
  今江健太、齋藤祐樹、木崎速人、毛瀚、立野浩輝、宮下惇嗣、関水和久、垣内力
- Organizer
  第14回次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉大学亥鼻キャンパス（千葉県千葉市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 糖尿病宿主への感染に必要な黄色ブドウ球菌の新規病原性因子HdvA/Hbpタンパク質複合体はGlcNAc-mal脱アセチル化酵素として働く2015
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第14回次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉大学亥鼻キャンパス（千葉県千葉市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 黄色ブドウ球菌のHMG-CoAレダクターゼのペプチドグリカン合成における役割2015
- Author(s)
  松本靖彦、安川淳一郎、石井雅樹、林陽平、宮崎真也、関水和久
- Organizer
  第６０回日本ブドウ球菌研究会
- Place of Presentation
  広島大学東京オフィス（港区芝浦）
- Year and Date
  2015-09-19
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] マウス臓器に感染した黄色ブドウ球菌の網羅的遺伝子発現解析2015
- Author(s)
  浜本洋、扇喜秀、鈴木穣、Paudel Atmika, 関水和久
- Organizer
  第27回微生物シンポジウム
- Place of Presentation
  岡山大学（岡山県岡山市）
- Year and Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 糖尿病合併症に対する生体内ポリアミンの防御作用2015
- Author(s)
  松本靖彦、東恭平、石井雅樹、五十嵐一衛、関水和久
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド、兵庫（神戸市）
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 黄色ブドウ球菌のGlcNAc-malを介した糖尿病宿主への病原性発揮機構2015
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第9回細菌学若手コロッセウム
- Place of Presentation
  KKRホテル敬天閣、鹿児島（鹿児島市）
- Year and Date
  2015-11-23
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 糖尿病宿主への感染に必要な黄色ブドウ球菌の新規病原性因子HdvA/Hbpタンパク質複合体はGlcNAc-mal脱アセチル化酵素として働く2015
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第14回次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉大学、千葉（千葉市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 宿主臓器における遺伝子発現上昇を指標とした黄色ブドウ球菌の新規病原性因子の探索2015
- Author(s)
  扇喜秀、浜本洋、鈴木穣、関水和久
- Organizer
  BMB2015　第38回日本分子生物学会年会、第88回日本生化学会　合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 高度バンコマイシン耐性黄色ブドウ球菌に対するバンコマイシンとβ-ラクタム系抗生物質の併用効果2015
- Author(s)
  田渕史晃、松本靖彦、石井雅樹、龍野桂太、岡崎充宏、佐藤智明、森屋恭爾、関水和久
- Organizer
  第98回日本細菌学会関東支部総会
- Place of Presentation
  東京歯科大学（東京都千代田区）
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 糖尿病宿主に対する病原性因子であるHdvAタンパク質はHbpタンパク質と複合体を形成し、黄色ブドウ球菌のGlcNAc-malを脱アセチル化する2015
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第27回微生物シンポジウム
- Place of Presentation
  就実大学、岡山（岡山市）
- Year and Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 宿主臓器における遺伝子発現上昇を指標とした黄色ブドウ球菌の新規病原性因子の探索2015
- Author(s)
  扇喜秀、浜本洋、鈴木穣、関水和久
- Organizer
  第14回次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉大学亥鼻キャンパス（千葉県千葉市）
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 糖尿病宿主に対する病原性因子であるHdvAタンパク質はHbpタンパク質と複合体を形成し、黄色ブドウ球菌のGlcNAc-malを脱アセチル化する2015
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第27回微生物シンポジウム
- Place of Presentation
  岡山大学（岡山県岡山市）
- Year and Date
  2015-09-04
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] Identification and mechanistic analysis of novel antibiotic “Lysocin E”2015
- Author(s)
  Kazuhisa Sekimizu, Hiroshi Hamamoto
- Organizer
  The international chemical congress of pacific basin societies 2015 (Pacifichem 2015)
- Place of Presentation
  Honolulu (Hawaii, USA)
- Year and Date
  2015-12-15
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 黄色ブドウ球菌のGlcNAc-malを介した糖尿病宿主への病原性発揮機構2015
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第9回細菌学若手コロッセウム
- Place of Presentation
  レインボー桜島（鹿児島県鹿児島市）
- Year and Date
  2015-11-23
- Data Source
  KAKENHI-PROJECT-15H05783
[Presentation] 高度バンコマイシン耐性黄色ブドウ球菌に対するバンコマイシンとβ-ラクタム系抗生物質の併用効果2015
- Author(s)
  田渕史晃、松本靖彦、石井雅樹、龍野桂太、岡崎充宏、佐藤智明、森屋恭爾、関水和久
- Organizer
  第98回日本細菌学会関東支部総会
- Place of Presentation
  東京歯科大学、東京（千代田区）
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] Cryptococcus neoformansの感染機構の解明のためのカイコ感染モデルの確立2015
- Author(s)
  松本靖彦、清水公徳、川本進、関水和久
- Organizer
  第36回関東医真菌懇話会
- Place of Presentation
  京王プラザホテル、東京（新宿区）
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 高度バンコマイシン耐性黄色ブドウ球菌に対する抗生物質の新規併用療法の探索2015
- Author(s)
  田渕史晃、松本靖彦、石井雅樹、龍野桂太、岡崎充宏、佐藤智明、森屋恭爾、関水和久
- Organizer
  日本細菌学会関東支部インターラボセミナー
- Place of Presentation
  国際医療研究センター研究所、東京（新宿区）
- Year and Date
  2015-08-06
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 糖尿病宿主感染に必要な黄色ブドウ球菌の病原性因子の同定2015
- Author(s)
  松本靖彦、宮崎真也、林陽平、石井雅樹、坂上徹、垣内力、関水和久
- Organizer
  第23回分子寄生虫学ワークショップ／第13回分子寄生虫・マラリア研究フォーラム合同大会
- Place of Presentation
  帯広畜産大学、北海道（帯広市）
- Year and Date
  2015-08-30
- Invited
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] The Mechanism of Glucose-dependent Virulence in Staphylococcus aureus2014
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第3回感染症若手フォーラム
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 黄色ブドウ球菌のコロニースプレッディング2014
- Author(s)
  垣内力、大前陽輔、関水和久
- Organizer
  第87回日本細菌学会総会(シンポジウム)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] Novel and therapeutically effective antibacterial agent targetting the sigma factor of bacterial RNA polymerase2014
- Author(s)
  Paudel Atmika, Hamamoto Hiroshi, Sekimizu Kazuhisa
- Organizer
  東京大学生命科学シンポジウム2014
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-13F03093
[Presentation] 黄色ブドウ球菌のGlcNAc-mal脱アセチル化活性は高血糖宿主に対する病原性に必要である2014
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第59回日本ブドウ球菌研究会
- Place of Presentation
  東京（府中市）
- Year and Date
  2014-08-04
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 黄色ブドウ球菌のコロニースプレッディング2014
- Author(s)
  垣内力、大前陽輔、関水和久
- Organizer
  第８７回日本細菌学会総会（シンポジウム）
- Place of Presentation
  タワーホール船堀、江戸川区、東京
- Invited
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 新規抗生物質カイコシンの作用機序と宿主因子による活性化2014
- Author(s)
  浜本洋、安川淳一朗、石井健一、安達達朗、関水和久
- Organizer
  日本薬学会第134年会（シンポジウム）
- Place of Presentation
  ホテル日航熊本、熊本
- Invited
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] カイコNPC2タンパク質はオートファジーの誘導を介してマウスがん細胞の増殖を抑制する2014
- Author(s)
  安達健朗、稲垣善則、松本靖彦、関水和久
- Organizer
  第14回東京大学生命科学シンポジウム
- Place of Presentation
  東京（文京区）
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 糖尿病宿主に対する黄色ブドウ球菌の感染におけるグルコース応答機構の役割2014
- Author(s)
  石井雅樹、松本靖彦、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第87回日本細菌学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 黄色ブドウ球菌の新規タンパク質Hbpは高血糖宿主に対する病原性因子HdvAタンパク質のGlcNAc-mal脱アセチル化活性に必要である2014
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  2014年インターラボセミナー
- Place of Presentation
  東京（豊島区）
- Year and Date
  2014-11-29
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 黄色ブドウ球菌のリンゴ酸-N-アセチルグルコサミン脱アセチル化酵素を介した糖尿病宿主に対する病原性発揮機構2014
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第14回東京大学生命科学シンポジウム
- Place of Presentation
  東京（文京区）
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] Regulation of innate immune responses by an insect cytokine, paralytic peptide, in the silkworm Bombyx mori.2014
- Author(s)
  Kenichi Ishii, Hiroshi Hamamoto, Kazuhisa Sekimizu
- Organizer
  1st Asian Invertebrate Immunity Symposium
- Place of Presentation
  釜山、韓国
- Invited
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 新規抗生物質カイコシンの作用機序と宿主因子による活性化2014
- Author(s)
  浜本洋、安川淳一朗、石井健一、安達達朗、関水和久
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学（熊本県熊本市）
- Invited
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] 黄色ブドウ球菌のグルコース応答システムを介した病原性発揮機構2013
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第12回次世代を担う若手ファーマ・バイオフォーラム2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] カイコ病態モデルを利用した医薬品の探索研究2013
- Author(s)
  浜本洋、石川繭子、瀬筒秀樹、坪田拓也、片岡啓子、松本靖彦、垣内力、関水和久
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] シルクワームによる挑戦2013
- Author(s)
  関水和久
- Organizer
  日本動物実験代替法学会第26回大会(ランチョンセミナー)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 黄色ブドウ球菌の病原性発現におけるrRNA のメチル化の役割2013
- Author(s)
  久間達彦、木村聡、鈴木勉、関水和久、垣内力
- Organizer
  第12回次世代を担う若手ファーマ・バイオフォーラム2013
- Place of Presentation
  東京大学本郷キャンパス、文京区、東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] Molecular Target analysis of Novel Antibiotics Kaikosins2013
- Author(s)
  Hiroshi Hamamoto, Jie Su, Atmika Paudel, Makoto Urai, Keiko Kataoka, Kazuhisa Sekimizu
- Organizer
  53th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
- Place of Presentation
  Denver (USA)
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] 無脊椎動物を用いた肺炎桿菌感染モデルによる臨床分離株の病原性評価2013
- Author(s)
  林陽平、松本靖彦、石井雅樹、龍野桂太、岡崎充宏、森屋恭爾、関水和久
- Organizer
  2014年インターラボセミナー
- Place of Presentation
  東京
- Year and Date
  2013-01-25
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] Niemann-Pick disease type C2 タンパク質は脂肪蓄積を促進する2013
- Author(s)
  安達健朗、石井健一、松本靖彦、林陽平、浜本洋、関水和久
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京大学本郷キャンパス、文京区、東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] シルクワームによる挑戦2013
- Author(s)
  関水和久
- Organizer
  日本動物実験代替法学会第26回大会
- Place of Presentation
  京都テレサ（京都府京都市）
- Invited
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] 黄色ブドウ球菌のN-アセチルグルコサミン代謝を介したグルコース応答性の病原性発揮機構2013
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第96回日本細菌学会関東支部総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] カイコを用いた真菌感染症研究2013
- Author(s)
  松本靖彦、上野圭吾、清水公徳、金城雄樹、知花博治、川本進、関水和久
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] Silkwormを用いた急性経口毒性試験代替法の開発第2報2013
- Author(s)
  杉田拓也、山本裕、植木拓朗、西田智、浜本洋、松本靖彦、関水和久、奥村秀信
- Organizer
  日本動物実験代替法学会第26回大会
- Place of Presentation
  京都テルサ、京都市、京都
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 新規リポペプチド系抗生物質カイコシンの標的同定2013
- Author(s)
  関水和久、浜本洋
- Organizer
  学術領域研究「天然物ケミカルバイオロジー:分子標的と制御」第4回公開シンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] 新規機能性RNA psm-mecはagrA遺伝子の翻訳を抑制してメチシリン耐性黄色ブドウ球菌の病原性を抑制する2013
- Author(s)
  幾尾真理子, 齋藤裕樹, 大前陽輔, 毛瀚, 長野源太郎, 藤幸知子, 沼田俊介, 韓笑, 小幡佳津明, 長谷川節雄, 山口博樹, 猪口孝一, 伊藤輝代, 平松啓一, 伊藤孝司, 関水和久, 垣内力
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜、神奈川
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] rRNAのメチル化による翻訳忠実性の維持が黄色ブドウ球菌の病原性に寄与する2013
- Author(s)
  久間達彦, 木村聡, 鈴木勉, 関水和久, 垣内力
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  神奈川(横浜)
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] カイコ病態モデルを利用した医薬品の探索研究2013
- Author(s)
  浜本洋、石川繭子、瀬筒秀樹、坪田拓也、片岡啓子、松本靖彦、垣内力、関水和久
- Organizer
  日本薬学会第133年会
- Invited
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] 黄色ブドウ球菌に見出された病原性抑制機構2013
- Author(s)
  垣内力、齋藤裕樹、幾尾真理子、大前陽輔、毛瀚、長野源太郎、藤幸知子、沼田俊介、韓笑、小幡佳津明、長谷川節雄、山口博樹、猪口孝一、伊藤輝代、平松啓一、関水和久
- Organizer
  第３６回日本分子生物学会年会（ワークショップ）
- Place of Presentation
  神戸ポートアイランド、神戸
- Invited
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] カイコ細菌感染モデルを用いた治療有効な新規抗生物質カイコシンの作用機序解析2013
- Author(s)
  安川淳一朗、浜本洋、Jie Su、Atmika Paudel、浦井誠、石井健一、安達達朗、西田智、関水和久
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] 無脊椎動物における適応免疫機構2013
- Author(s)
  宮下惇嗣, 川崎清史, 関水和久, 垣内力
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜、神奈川
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 薬剤性組織傷害評価モデルとしてのGFPトランスジェニックカイコの応用2013
- Author(s)
  稲垣善則、松本靖彦、松谷安恵、瀬筒秀樹、関水和久
- Organizer
  日本動物実験代替法学会第26回大会
- Place of Presentation
  京都テルサ、京都市、京都
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] シルクワームによる挑戦2013
- Author(s)
  関水和久
- Organizer
  日本動物実験代替法学会第26回大会（ランチョンセミナー）
- Place of Presentation
  京都テルサ、京都市、京都
- Invited
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 黄色ブドウ球菌のグルコース応答を介した病原性調節機構2013
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第58回日本ブドウ球菌研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] LPSトランスポーターの変異による大腸菌の高病原性化2013
- Author(s)
  吉海周, 若松愛, 宮下惇嗣, 松本靖彦, 磯貝隆夫, 関水和久, 垣内力
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  神奈川(横浜)
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] カイコ細菌感染モデルを用いた治療有効な新規抗生物質カイコシンの作用機序解析2013
- Author(s)
  安川淳一朗、浜本洋、Jie Su、Atmika Paudel、浦井誠、石井健一、安達達朗、西田智、関水和久
- Organizer
  第25回微生物シンポジウム
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2013-09-06
- Data Source
  KAKENHI-PROJECT-13F03093
[Presentation] 黄色ブドウ球菌に見出された病原性抑制機構2013
- Author(s)
  垣内力、齋藤裕樹、幾尾真理子、大前陽輔、毛瀚、長野源太郎、藤幸知子、沼田俊介、韓笑、小幡佳津明、長谷川節雄、山口博樹、猪口孝一、伊藤輝代、平松啓一、関水和久
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 外膜構造の変化により非病原性大腸菌K-12株が高病原性化する2013
- Author(s)
  吉海周、若松愛、宮下惇嗣、松本靖彦、磯貝隆夫、関水和久、垣内力
- Organizer
  第13回東京大学生命科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2013-06-08
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 黄色ブドウ球菌のグルコース応答システムを介した病原性発揮機構2013
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第12回次世代を担う若手ファーマ・バイオフォーラム2013
- Place of Presentation
  東京大学本郷キャンパス、文京区、東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] Antibacterial activity of a novel lipopeptide antibiotic, kaikosin E, is enhanced by host factors2013
- Author(s)
  Jyunichiro Yasukawa, Hiroshi Hamamoto, Kazuhisa Sekimizu
- Organizer
  The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] シルクワームによる挑戦2013
- Author(s)
  関水和久
- Organizer
  日本実験動物抱いた法学会第26回大会
- Place of Presentation
  京都テレサ, 京都府京都市
- Invited
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] DUF402ドメインを有するSA1684は黄色ブドウ球菌の新規病原性因子である2013
- Author(s)
  Han Mao, 齊藤祐樹, 関水和久, 垣内力
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜、神奈川
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] カイコを用いたスギ花粉に付着した細菌の病原性の評価2013
- Author(s)
  胡媛、浜本洋、関水和久
- Organizer
  第12回次世代を担う若手ファーマ・バイオフォーラム2013
- Place of Presentation
  東京大学本郷キャンパス、文京区、東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 新規抗生物質カイコシンによる新規細胞膜破壊メカニズム2013
- Author(s)
  安川淳一朗、浜本洋、Jie Su、Atmika Paudel、浦井誠、石井健一、安達健朗、西田智、関水和久
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京大学（東京都文京区）
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] 黄色ブドウ球菌のグルコース応答システムの感染における役割2013
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第7回細菌学若手コロッセウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 黄色ブドウ球菌の毒素トランスポーターの同定2013
- Author(s)
  吉海周、齊藤祐樹、Nwibo Daniel Don、関水和久、垣内力
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京大学本郷キャンパス、文京区、東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] Molecular Target analysis of Novel Antibiotics Kaikosins2013
- Author(s)
  H. HAMAMOTO, J. Su, A. PAU DEL, M. URAI, K. KATAOKA, K. SEKIMIZU
- Organizer
  53th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
- Place of Presentation
  USA (Denver)
- Data Source
  KAKENHI-PROJECT-13F03093
[Presentation] 生体因子による新規抗生物質カイコシンの抗菌活性の促進2013
- Author(s)
  安川淳一朗、浜本洋、Su jie、Paudel Atmika、浦井誠、西田智、関水和久
- Organizer
  第12回次世代を担う若手ファーマ・バイオフォーラム2013
- Place of Presentation
  東京大学本郷キャンパス、文京区、東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 新規抗視物質カイコシンの作用機序解析2013
- Author(s)
  浜本洋、Su Jie、Atmika Paudel、西田智、関水和久
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  静岡県立大学(静岡県静岡市)
- Data Source
  KAKENHI-PROJECT-13F03093
[Presentation] ヒト病態モデルカイコを活用した新薬の開発と課題2013
- Author(s)
  関水和久
- Organizer
  第５回公開シンポジウム「カイコ産業の未来」
- Place of Presentation
  東京
- Year and Date
  2013-01-18
- Invited
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] 新規機能性RNA psm-mecは agrA遺伝子の翻訳を抑制してメチシリン耐性黄色ブドウ球菌の病原性を抑制する2013
- Author(s)
  幾尾真理子, 齋藤裕樹, 大前陽輔, 毛瀚, 長野源太郎, 藤幸知子, 沼田俊介, 韓笑, 小幡佳津明, 長谷川節雄, 山口博樹, 猪口孝一, 伊藤輝代, 平松啓一, 伊藤孝司, 関水和久, 垣内力
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  神奈川(横浜)
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] カイコを用いた真菌感染症研究2013
- Author(s)
  Fungal infectious disease research using silkworm, Bombyx mori 松本靖彦、上野圭吾、清水公徳、金城雄樹、知花博治、川本進、関水和久
- Organizer
  第86回日本細菌学会総会
- Place of Presentation
  千葉
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] rRNA のメチル化による翻訳忠実性の維持が黄色ブドウ球菌の病原性に寄与する2013
- Author(s)
  久間達彦, 木村聡, 鈴木勉, 関水和久, 垣内力
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] カイコは細菌リポ多糖に対する応答を増強させ、感染抵抗性を獲得する2013
- Author(s)
  宮下惇嗣、木崎速人、川崎清史、関水和久、垣内力
- Organizer
  第96回日本細菌学会関東支部総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] カイコ病態モデルを利用した医薬品の探索研究2013
- Author(s)
  浜本洋、石川繭子、瀬筒秀樹、坪田拓也、片岡啓子、松本靖彦、垣内力、関水和久
- Organizer
  日本薬学会　第133年会
- Place of Presentation
  東京
- Year and Date
  2013-03-27
- Invited
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] Molecular Target analysis of the Novel Antibiotics Kaikosins2013
- Author(s)
  Kazuhisa Sekimizu, Hiroshi Hamamoto
- Organizer
  The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] 黄色ブドウ球菌の毒素トランスポーターの同定2013
- Author(s)
  吉海周、齊藤祐樹、関水和久、垣内力
- Organizer
  2014年インターラボセミナー
- Place of Presentation
  東京
- Year and Date
  2013-01-25
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 無脊椎動物における適応免疫機構2013
- Author(s)
  宮下惇嗣, 川崎清史, 関水和久, 垣内力
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  神奈川(横浜)
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] DUF402ドメインを有するSA1684は黄色ブドウ球菌の新規病原性因子である2013
- Author(s)
  Han Mao, 齊藤祐樹, 関水和久, 垣内力
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  神奈川(横浜)
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] シルクワームによる挑戦2013
- Author(s)
  関水和久
- Organizer
  日本動物実験代替法学会第26回大会
- Place of Presentation
  京都テレサ（京都府京都市）
- Invited
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] 新規抗生物質カイコシンによる新規細胞膜破壊メカニズム2013
- Author(s)
  安川淳一朗、浜本洋、Jie Su、Atmika Paudel、浦井誠、石井健一、安達健朗、西田智、関水和久
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京大学(東京都文京区)
- Data Source
  KAKENHI-PROJECT-13F03093
[Presentation] カイコは細菌リポ多糖に対する応答を増強させ、感染抵抗性を獲得する2013
- Author(s)
  宮下惇嗣、木崎速人、川崎清史、関水和久、垣内力
- Organizer
  第９６回日本細菌学会関東支部総会
- Place of Presentation
  東京ドームホテル、東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 新規抗視物質カイコシンの作用機序解析2013
- Author(s)
  浜本洋、Su Jie、Atmika Paudel、西田智、関水和久
- Organizer
  第25回微生物シンポジウム
- Place of Presentation
  静岡県立大学（静岡県静岡市）
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] The role of glucose response system in infection of Staphylococcus aureus2013
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第13回東京大学生命科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2013-06-08
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] Characterization and mechanistic analysis of novel antibiotics Kaikosin, produced by Lysobacter sp.2013
- Author(s)
  Hiroshi Hamamoto, Su Jie, Paudel Atomika, Makoto Urai, Kazuhisa Sekimizu
- Organizer
  International Symposium on Genome Science Expanding Frontiers of Genome Science
- Place of Presentation
  東京
- Year and Date
  2013-01-09
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] 黄色ブドウ球菌のHMG-CoAレダクターゼの活性は基質によるアロステリック制御を受ける2012
- Author(s)
  安川淳一朗、松本靖彦、林陽平、宮崎真也、関水和久
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] Silkworm(カイコ)を用いた急性経口毒性試験代替法の投与方法の検討2012
- Author(s)
  植木拓朗、杉田拓也、浜本洋、松本靖彦、関水和久、奥村秀信
- Organizer
  第25回日本動物実験代替法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] 新規抗生物質カイコシンの作用機序解析に関する研究2012
- Author(s)
  浜本洋、Su Jie、Atmika Paudel、浦井誠、片岡啓子、関水和久
- Organizer
  第３４回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  京都
- Year and Date
  2012-11-15
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] 高血糖カイコ感染モデルを用いた糖尿病宿主に対する感染に必要な細菌の遺伝子の同定2012
- Author(s)
  松本靖彦、宮崎真也、坂上徹、山岸徹、大西忠博、垣内力、関水和久
- Organizer
  感染症若手フォーラム
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 日本化学療法学会の将来を考える：これからの新規抗菌薬の発見と開発2012
- Author(s)
  関水和久
- Organizer
  第60回日本化学療法学会東日本支部総会　合同学会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] Isd-mediated heme utilization in Staphylococcus aureus is required for infection in diabetic hosts2012
- Author(s)
  Yasuhiko Matsumoto, Shinya Miyazaki, Yohei Hayashi, Toru Sakagami, Masaki Ishii, Chikara Kaito, and Kazuhisa Sekimizu
- Organizer
  第11回あわじしま感染症・免疫フォーラム
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] Silkworm(カイコ)を用いた急性毒性試験代替法の開発2012
- Author(s)
  杉田拓也、植木拓朗、浜本洋、松本靖彦、関水和久、奥村秀信
- Organizer
  第25回日本動物実験代替法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] 黄色ブドウ球菌のヘム取り込み機構は、糖尿病状態の宿主に感染するために必要である2012
- Author(s)
  松本靖彦、宮崎真也、林陽平、石井雅樹、坂上徹、垣内力、関水和久
- Organizer
  第57回日本ブドウ球菌研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] カイコモデルでの治療効果を指標として発見された新規抗生物質カイコシン2012
- Author(s)
  関水和久
- Organizer
  第2回天然物ケミカルバイオロジー公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2012-06-16
- Invited
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] Isdシステムを介したヘムの獲得が糖尿病宿主に対する黄色ブドウ球菌の病原性に必要である2012
- Author(s)
  林陽平、松本靖彦、宮崎真也、坂上徹、石井雅樹、垣内力、関水和久
- Organizer
  第6回細菌学若手コロッセウム
- Place of Presentation
  東京(八王子)
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] Purification of a serum factor enhancing Kaikosin E activity against Staphylococcus aureus2012
- Author(s)
  Su Jie, Hiroshi Hamamoto, Kazuhisa Sekimizu
- Organizer
  The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  京都
- Year and Date
  2012-10-31
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] 日本化学療法学会の将来を考える：これからの新規抗菌薬の発見と開発2012
- Author(s)
  関水和久
- Organizer
  第60回日本化学療法学会東日本支部総会　合同学会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] Mechanistic Analysis of Novel Antibiotics Kaikosins2012
- Author(s)
  Kazuhisa Sekimizu, Hiroshi Hamamoto
- Organizer
  The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  京都
- Year and Date
  2012-10-31
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] Isdシステムを介したヘムの獲得が黄色ブドウ球菌の糖尿病宿主に対する病原性に必要である2012
- Author(s)
  宮崎真也、松本靖彦、坂上徹、福永ディミトリ広、林陽平、垣内力、関水和久
- Organizer
  感染症若手フォーラム
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] Identification of bacterial genes required for virulence in diabetic hosts2012
- Author(s)
  Shinya Miyazaki, Yasuhiko Matsumoto, Yohei Hayashi, Tohru Sakagami, Chikara Kaito, Keita Tatsuno, Mitsuhiro Okazaki, Shu Okugawa, Kyoji Moriya, Kazuhisa Sekimizu
- Organizer
  第85回日本細菌学会総会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 日本化学療法学会の将来を考える：これからの新規抗菌薬の発見と開発2012
- Author(s)
  関水和久
- Organizer
  第60回日本化学療法学会東日本支部総会　合同学会
- Place of Presentation
  東京
- Year and Date
  2012-10-10
- Invited
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] 高血糖カイコ感染モデルを用いた糖尿病宿主に対する感染に必要な細菌の遺伝子の同定2012
- Author(s)
  松本靖彦、宮崎真也、林陽平、坂上徹、石井雅樹、山岸徹、大西忠博、垣内力、関水和久
- Organizer
  第6回細菌学若手コロッセウム
- Place of Presentation
  東京(八王子)
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] カイコモデルでの治療効果を指標として発見された新規抗生物質カイコシン2012
- Author(s)
  関水和久
- Organizer
  第2回天然物ケミカルバイオロジー公開シンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 新規環状リポペプチド系抗生物質カイコシンの作用機序解析2012
- Author(s)
  浜本洋、Su Jie、浦井誠、Atmika Paudel、片岡啓子、関水和久
- Organizer
  第２４回微生物シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2012-09-03
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] 病原性細菌によるカイコ感染モデルを利用した新規抗生物質の探索2012
- Author(s)
  関水和久
- Organizer
  東京大学大学院農学生命科学研究科微生物潜在機能探索寄付講座開設記念シンポジウム「微生物機能の多様性」～東京大学のさまざまな部局における微生物研究～
- Place of Presentation
  東京
- Year and Date
  2012-11-28
- Invited
- Data Source
  KAKENHI-PUBLICLY-24102510
[Presentation] Mechanistic Analysis of Novel Antibiotics Kaikosins2012
- Author(s)
  Kazuhisa Sekimizu
- Organizer
  The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] メバロン酸はペプチドグリカン合成のための基質の前駆体として黄色ブドウ球菌の増殖に必要である2012
- Author(s)
  安川淳一朗、松本靖彦、林陽平、宮﨑真也、関水和久
- Organizer
  第95回日本細菌学会関東支部会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 病原性細菌によるカイコ感染モデルを利用した新規抗生物質の探索2012
- Author(s)
  関水和久
- Organizer
  東京大学大学院農学生命科学研究科微生物潜在機能探索寄付講座開設記念シンポジウム「微生物機能の多様性」〜東京大学のさまざまな部局における微生物研究〜
- Place of Presentation
  東京
- Year and Date
  2012-11-28
- Invited
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] 病原性細菌によるカイコ感染モデルを利用した新規抗生物質の探索2012
- Author(s)
  関水和久
- Organizer
  東京大学大学院農学生命科学研究科微生物潜在機能探索寄付講座開設記念シンポジウム「微生物機能の多様性」～東京大学のさまざまな部局における微生物研究～
- Place of Presentation
  東京
- Year and Date
  2012-11-28
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 日本化学療法学会の将来を考える : これからの新規抗菌薬の発見と開発2012
- Author(s)
  関水和久
- Organizer
  第60回日本化学療法学会東日本支部総会合同学会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] 薬剤性組織障害モデルとしてのカイコの有用性2012
- Author(s)
  稲垣善則、松本靖彦、浜本洋、片岡啓子、松橋直也、杉田拓也、植木拓朗、奥村秀信、関水和久
- Organizer
  第25回日本動物実験代替法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] カイコ幼虫感染症モデルを用いた、バイオアッセイによる感染症治療薬シーズの開発2011
- Author(s)
  関水和久
- Organizer
  彩都産学官連携シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2011-01-27
- Data Source
  KAKENHI-PUBLICLY-21022015
[Presentation] Bacterial Isd system mediated heme utilization is required for Staphlococcus aureus virulence in diabetic hosts2011
- Author(s)
  Shinya Miyazaki, Yasuhiko Matsumoto, Tohru Sakagami, Chikara Kaito, Kazuhisa Sekimizu
- Organizer
  IUMS 2011 Sapporo The Unlimited World of Microbes
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] カイコ幼虫感染症モデルを用いた、バイオアッセイによる感染症治療薬シーズの開発2011
- Author(s)
  関水和久
- Organizer
  彩都産学官連携シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2011-01-27
- Data Source
  KAKENHI-PROJECT-20390021
[Presentation] 肝胆膵領域の癌におけるKL-6ムチンの臨床病理学的有用性2011
- Author(s)
  稲垣善則, 唐偉, 長谷川潔, 菅原寧彦, 関水和久, 國土典宏
- Organizer
  第52回日本組織細胞化学会総会・学術集会
- Place of Presentation
  石川県金沢市(招待講演)
- Year and Date
  2011-09-25
- Data Source
  KAKENHI-PROJECT-21390373
[Presentation] 新規病原性遺伝子群を基盤とする病原性発現システムの把握2011
- Author(s)
  関水和久
- Organizer
  特定領域感染現象のマトリックス第7回全体班会議
- Place of Presentation
  東京
- Year and Date
  2011-01-13
- Data Source
  KAKENHI-PUBLICLY-21022015
[Presentation] 細菌ならびに真菌の糖尿病宿主における病原性を解析するための無脊椎動物を用いた高血糖感染モデル2011
- Author(s)
  宮崎真也、松本靖彦、林陽平、坂上徹、垣内力、龍野桂太、岡崎充宏、奥川周、森屋恭爾、関水和久
- Organizer
  第94回日本細菌学会関東支部総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] Structural and biochemical analysis of a virulence regulatory factor CvfB in Staphylococcus aureus2011
- Author(s)
  Yasuhiko Matsumoto, Shinya Miyazaki, Chikara Kaito, Kazuhisa Sekimizu
- Organizer
  IUMS 2011 Sapporo The Unlimited World of Microbes
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] Polyamine inhibits growth defect in hyperglycemic silkworm2011
- Author(s)
  Yasuhiko Matsumoto, Kyohei Higashi, Kazuei Igarashi, Kazuhisa Sekimizu
- Organizer
  Gordon Research Conferences-Polyamines-
- Place of Presentation
  Waterville Valley, NH, America(招待講演)
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 新規病原性遺伝子群を基盤とする病原性発現システムの把握2011
- Author(s)
  関水和久
- Organizer
  「特定領域」感染現象のマトリックス第7回全体班会議
- Place of Presentation
  東京
- Year and Date
  2011-01-13
- Data Source
  KAKENHI-PROJECT-20390021
[Presentation] カイコ創薬のすすめ2010
- Author(s)
  関水和久
- Organizer
  日本農芸化学会西日本支部若手シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-20390021
[Presentation] カイコ病態モデルを利用した医薬品開発2010
- Author(s)
  関水和久
- Organizer
  第35回製剤セミナー
- Place of Presentation
  静岡
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PUBLICLY-21022015
[Presentation] Discovery of novel, therapeutically effective antibiotics by using the silkworm infection model2010
- Author(s)
  関水和久
- Organizer
  The 5th Japan-Korea Chemical Biology symposium
- Place of Presentation
  韓国釜山
- Data Source
  KAKENHI-PUBLICLY-21022015
[Presentation] Use of silkworm for evaluation bacterial pathogenisity and the therapeutic effects of antibiosics2010
- Author(s)
  関水和久
- Organizer
  第10回あわじしま感染症・免疫フォーラム招待講演
- Place of Presentation
  兵庫県
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-20390021
[Presentation] カイコ病態モデルを利用した医薬品開発2010
- Author(s)
  関水和久
- Organizer
  第35回製剤セミナー
- Place of Presentation
  静岡
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-20390021
[Presentation] USE OF SILKWORMS FOR EVALUATION OF THERAPEUTIC EFFECTS OF AN TIBIOTICS2010
- Author(s)
  Kazuhisa Sekimizu
- Organizer
  9th NRCT-JSPSタイジョイントセミナー
- Place of Presentation
  バンコク,タイ
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20390021
[Presentation] カイコ創薬のすすめ2010
- Author(s)
  関水和久
- Organizer
  日本農芸化学会西日本支部若手シンポジウム
- Place of Presentation
  福岡
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PUBLICLY-21022015
[Presentation] Discovery of novel, therapeutically effective antibiotics by using the silkworm infection model2010
- Author(s)
  関水和久
- Organizer
  The 5th Japan-Korea Chemical Biology Symposium
- Place of Presentation
  韓国釜山
- Data Source
  KAKENHI-PROJECT-20390021
[Presentation] Use of Silkworms for Evaluating Bacterial Pathogenicity and the Therapeutic Effects of Antibiotics2010
- Author(s)
 Kazuhisa Sekimizu
- Organizer
 The 10^<th> Awaji International Forum on Infe ction and Immunity
- Place of Presentation
 淡路
- Data Source
 KAKENHI-PROJECT-20390021
[Presentation] Use of Silkworms for Evaluating Bacterial Pathogenicity and the Therapeutic Effects of Antibiotics2010
- Author(s)
 Kazuhisa Sekimizu
- Organizer
 The 10^<th> Awaji International Forum on Infection and Immunity
- Place of Presentation
 淡路
- Data Source
 KAKENHI-PUBLICLY-21022015
[Presentation] カイコモデルDMにおける観察研究2010
- Author(s)
  関水和久
- Organizer
  中頭病院講演会
- Place of Presentation
  ちばなホール(沖縄)
- Year and Date
  2010-01-14
- Data Source
  KAKENHI-PROJECT-20390021
[Presentation] 招待講演「Slikworm infection models for evaluation of bacterial pathogenecity and the rapeutic effects of antibiotics」2010
- Author(s)
  関水和久
- Organizer
  拠点大学交流事業 The 9th NRCT-JSPS Joint Seminar
- Place of Presentation
  バンコク
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-20390021
[Presentation] カイコを利用した医薬品開発2010
- Author(s)
  関水和久
- Organizer
  (社)日本薬剤学会第35回製剤セミナー招待講演
- Place of Presentation
  浜松市
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-20390021
[Presentation] カイコ創薬のすすめ2010
- Author(s)
  関水和久
- Organizer
  2010年度日本農芸化学会西日本支部若手シンポジウム招待講演
- Place of Presentation
  九州大学
- Year and Date
  2010-10-23
- Data Source
  KAKENHI-PROJECT-20390021
[Presentation] カイコモデルDMにおける観察研究2010
- Author(s)
  関水和久
- Organizer
  中頭病院講演会
- Place of Presentation
  ちばなホール(沖縄)
- Year and Date
  2010-01-14
- Data Source
  KAKENHI-PUBLICLY-21022015
[Presentation] USE OF SILKWORMS FOR EVALUATION OF THERAPEUTIC EFFECTS OF AN TIBIOTICS2010
- Author(s)
  Kazuhisa Sekimizu
- Organizer
  9th NRCT-JSPSタイジョイントセミナー
- Place of Presentation
  バンコク(タイ)
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PUBLICLY-21022015
[Presentation] ヒト病態モデルとしてのカイコ研究の現状と展望2009
- Author(s)
  関水和久
- Organizer
  公開シンポジウム「カイコ産業の未来～新産業を創出する遺伝子組換えカイコ～」農業生物資源研究所
- Place of Presentation
  群馬県庁ビジターセンター
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-20390021
[Presentation] カイコをモデル動物とした試験方法2009
- Author(s)
  関水和久
- Organizer
  日本動物実験代替法学会2009年技術講習会
- Place of Presentation
  臨床研究情報センター(神戸)
- Year and Date
  2009-08-21
- Data Source
  KAKENHI-PROJECT-20390021
[Presentation] ヒト病態モデルとしてのカイコ研究の現状と展望2009
- Author(s)
  関水和久
- Organizer
  公開シンポジウム「カイコ産業の未来～新産業を創出する遺伝子組換えカイコ～」農業生物資源研究所
- Place of Presentation
  群馬県庁ビジターセンター
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PUBLICLY-21022015
[Presentation] カイコをモデル動物とした試験方法2009
- Author(s)
  関水和久
- Organizer
  日本動物実験代替法学会2009年技術講習会
- Place of Presentation
  臨床研究情報センター(神戸)
- Year and Date
  2009-08-21
- Data Source
  KAKENHI-PUBLICLY-21022015
[Presentation] 病原性細菌によるカイコ感染モデルを利用した新規抗生物質の探索
- Author(s)
  関水和久
- Organizer
  東京大学大学院農学生命科学研究科微生物潜在機能探索寄付講座開設記念シンポジウム「微生物機能の多様性」～東京大学のさまざまな部局における微生物研究～
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24659041
[Presentation] 黄色ブドウ球菌のGlcNAc-mal脱アセチル化酵素は高血糖宿主に対する病原性に必要である
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都（京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 黄色ブドウ球菌におけるGlcNAc-mal代謝物を介した高血糖宿主に対する病原性発揮機構の解明
- Author(s)
  石井雅樹、松本靖彦、林陽平、宮崎真也、坂上徹、垣内力、関水和久
- Organizer
  第8回細菌学若手コロッセウム
- Place of Presentation
  北海道（ニセコ）
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] The primary sigma factor of bacterial RNA polymerase is involved in antimicrobial activity of a novel therapeutically effective antimicrobial agent.
- Author(s)
  Paudel Atmika, Hamamoto Hiroshi, Kaneko Keichi, Matsunaga Shigeki, Suzuki Yutaka, Kanai Motomu, Kazuhisa Sekimizu.
- Organizer
  The 3rd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Year and Date
  2014-10-28 – 2014-10-29
- Data Source
  KAKENHI-PROJECT-13F03093
[Presentation] Role of HdvA in adaptive mechanism of Staphylococcus aureus to diabetic host　environment
- Author(s)
  石井雅樹、松本靖彦、宮崎真也、垣内力、関水和久
- Organizer
  第88回日本細菌学会総会
- Place of Presentation
  岐阜（岐阜市）
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] 糖尿病治療薬の薬効評価のための高血糖カイコモデルの利用
- Author(s)
  松本靖彦、関水和久
- Organizer
  第27回日本動物実験代替法学会
- Place of Presentation
  神奈川（横浜市）
- Year and Date
  2014-12-05 – 2014-12-07
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] カイコ病態モデルを利用した医薬品の探索研究
- Author(s)
  浜本洋、石川繭子、瀬筒秀樹、坪田拓也、片岡啓子、松本靖彦、垣内力、関水和久
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23249009
[Presentation] 高血糖カイコにおけるインスリン抵抗性とポリアミン合成の関係
- Author(s)
  松本靖彦、東恭平、五十嵐一衛、関水和久
- Organizer
  日本ポリアミン学会第6回年会
- Place of Presentation
  東京（品川区）
- Year and Date
  2015-01-19 – 2015-01-20
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] Novel Therapeutically Effective Antimicrobial Agent Targets Bacterial RNA Polymerase Sigma Factor A
- Author(s)
  Paudel Atmika, Hamamoto Hiroshi, Kaneko Keichi, Matsunaga Shigeki, Suzuki Yutaka, Kanai Motomu, Kazuhisa Sekimizu
- Organizer
  The 54th Interscience Conference on Antimicrobial Agents and Chemotherapy
- Place of Presentation
  Washington（USA）
- Year and Date
  2014-09-05 – 2014-09-09
- Data Source
  KAKENHI-PROJECT-13F03093
[Presentation] 高血糖カイコ感染モデルを用いた糖尿病宿主に対する感染に必要な細菌の遺伝子の同定
- Author(s)
  松本靖彦、宮崎真也、林陽平、坂上徹、石井雅樹、垣内力、関水和久
- Organizer
  第26回微生物シンポジウム
- Place of Presentation
  東京（千代田区）
- Year and Date
  2014-09-19 – 2014-09-20
- Data Source
  KAKENHI-PROJECT-26460062
[Presentation] Host factors enhance the antimicrobial activity of a novel antibiotics kaikosin E,
- Author(s)
  Hiroshi Hamamoto, Su Jie, Atmika Paudel, Kenichi Ishii, Jyunichiro Yasukawa, Kazuhisa Sekimizu
- Organizer
  The 54th Interscience Conference on Antimicrobial Agents and Chemotherapy
- Place of Presentation
  Washington（USA）
- Year and Date
  2014-09-05 – 2014-09-09
- Data Source
  KAKENHI-PROJECT-13F03093
[Presentation] ヒト病態モデルカイコを活用した新薬の開発と課題
- Author(s)
  関水和久
- Organizer
  第５回公開シンポジウム「カイコ産業の未来」
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-23249009

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Sekimizu Kazuhisa 関水 和久

SEKIMIZU Kazuhisa 関水 和久

Research Projects

Research Products

Co-Researchers

Comprehensive analysis of pathogenic ncRNA in host environmentHost ResearcherOngoing

Host Researcher

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治療効果を指向した新規抗菌薬の創出Principal InvestigatorOngoing

Principal Investigator

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Comprehensive understanding of bacterial adaptation mechanism in diabetic host

Principal Investigator

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治療効果を指標に同定された新規抗菌薬の作用機序解析Host Researcher

Host Researcher

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新規リポペプチド系抗生物質カイコシンの標的同定Principal Investigator

Principal Investigator

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Review Section

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Establishment of screening system for antifungal drugs using silkworm fungus infection modelPrincipal Investigator

Principal Investigator

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Understanding of host-pathogen interaction by using silkworm infection modelPrincipal Investigator

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新規病原性遺伝子群を基盤とする病原性発現コアシステムの把握Principal Investigator

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Development of novel molecular-targeted medicine against aminopeptidase

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肝細胞がん特有の進行メカニズムに着目した新規化学療法剤の開発

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Elucidation of bacterial pathogenesis system based on a silkworm infection modelPrincipal Investigator

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カイコ感染モデルを用いたグラム陽性細菌に保存された病原性発現機構の解明Principal Investigator

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黄色ブドウ球菌の滑走能低下を指標とした抗菌治療薬に関する研究Principal Investigator

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Sekimizu Kazuhisa 関水和久

SEKIMIZU Kazuhisa 関水和久