Ishikawa Yoshinobu 石川吉伸

… Alternative Names

ISHIKAWA Yoshinobu 石川吉伸

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Researcher Number	00305004
Other IDs
Affiliation (Current)	2025: 湘南医療大学, 薬学部医療薬学科, 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 湘南医療大学, 薬学部医療薬学科, 教授 2016 – 2020: 静岡県立大学, 薬学部, 准教授 2016: 静岡県立大学, 薬学研究院, 准教授 2008 – 2014: University of Shizuoka, 薬学部, 准教授 2007: Kumamoto University, 大学院・医学薬学研究部, 講師 … More 2006: 熊本大学, 医学薬学研究部, 講師 2003 – 2004: 熊本大学, 大学院・医学薬学研究部, 講師 1999 – 2002: 熊本大学, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Drug development chemistry / 医薬分子機能学 / Basic Section 50020:Tumor diagnostics and therapeutics-related / Physical pharmacy Except Principal Investigator Physical pharmacy / Basic Section 63020:Radiation influence-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 38040:Bioorganic chemistry-related / Basic Section 50010:Tumor biology-related / Natural medicines / Physical pharmacy
Keywords	Principal Investigator 阻害剤 / テロメラーゼ / テロメア / 四重鎖 / ポルフィリン / 分子ドッキング / 結晶構造 / 金属酵素 / 有機化学 / 生物物理 … More / 薬学 / インシリコ創薬 / 分子認識 / 核酸 / 抗ガン剤 / DNA / AS-MS / 低分子 / PD-1 / 免疫チェックポイント / 結晶構造解析 / IC50 / 計算化学 / 静電ポテンシャル / 構造活性相関 / クロモン / ウレアーゼ / ハロゲン結合 / インフルエンザウィルス / ビキノリン / キレート / ドッキング / SBDD / RNAポリメラーゼ / ジケト酸 / インフルエンザ / 阻害 / 構造安定化 / グルーブ結合 / インターカレーション / 平衡透析 / 光切断 / CD / アクリジン / 蛍光 / 融解温度 … More Except Principal Investigator DNA / DNA修復経路 / RAD52 / 抗がん剤 / Resonance Ramen Spectroscopy / 共鳴ラマンスペクトル / Porphyrin / 光切断 / ポルフィリン / ASMS / 一本鎖アニーリング / 遺伝的不安定性 / DNA修復タンパク / 薬剤耐性 / 遺伝性疾患 / DNA損傷応答 / ゲノム不安定性 / 標的治療 / 経口投与 / 極低用量 / スクリーニング系 / 担がんマウス / BRCA変異がん / マウス実験 / 感受性 / 化合物合成 / SSA / 標的阻害 / 発がん / DNA損傷 / RECQL4 / DNA修復 / 構造活性相関 / 阻害剤 / RNA修飾酵素 / がん幹細胞特異的翻訳 / 低分子化合物開発 / 低分子化合物 / タンパク質合成 / がん幹細胞 / 患者層別化検証 / 阻害剤開発 / 膠芽腫幹細胞 / 翻訳制御機構 / 腫瘍幹細胞 / 膠芽腫 / エピトランスクリプトーム創薬 / AI / 受容体チロシンキナーゼ / KIT / VUS / 分子標的治療 / がんゲノム医療 / 免疫チェックポイント / PD-1/PD-L inhibitor / PD-1/PD-L1 inhibitor / PD-1/PD-L1 / PD-L1 / 生物活性試験 / 昆虫 / 化学構造解析 / 薬効成分 / 薬用植物 / 伝統医学 / 国際情報交換 / モンゴル国 / Substrate Specificity / Binding Constant / Equilibrium Dialysis / Drug Metabolism / Resonance Raman Spectroscopy / Cytochrome P450 / 平衡透析 / 基質特異性 / 結合定数 / 平衡誘析 / 薬物代謝 / 共鳴ラマン分光 / シトクロムP450 / Telomere / Photonuclease / テロメア / Heme Protein / Transcription Factor / Sensor Protein / Gas Molecules / シグナル伝達 / ガスセンサー / ヘムタンパク質 / 転写因子 / センサータンパク質 / ガス分子 / Induced CD Spectroscopy / Intercalation / Cleavage / アミノ基 / 塩基対 / アクリジン / シトクロムb / ヘム / 誘起CDスペクトル / インターカレーション / 切断 Less

AS-MSによるPD-1ーPD-L1低分子阻害剤の探索Principal Investigator
- Principal Investigator
  
  石川吉伸
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  湘南医療大学
Elucidation of regulatory mechanisms for cancer therapy resistance using DNA repair properties
- Principal Investigator
  
  香崎正宙
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  University of Occupational and Environmental Health, Japan
新規抗がん剤開発を目指すtRNA修飾酵素と阻害化合物の構造活性相関解明
- Principal Investigator
  
  安藤隆幸
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Shizuoka Institute of Environment and Hygiene
Development of epitranscriptome anticancer drugs targeting glioblastoma stem cells
- Principal Investigator
  
  Fujimura Atsushi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Okayama University
Innovative drug development targeting specific DNA repair pathway in cancer cells
- Principal Investigator
  
  Kohzaki Masaoki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  University of Occupational and Environmental Health, Japan
The development of a method to predict the function of variants of unknown significance that accumulate in cancer genome analysis for clinical application purposes
- Principal Investigator
  
  Serizawa Masakuni
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shizuoka Cancer Center Research Institute
Identification of small molecular compounds with PD-1 / PD-L1 inhibitory activity by in silico
- Principal Investigator
  
  Ashizawa Tadashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shizuoka Cancer Center Research Institute
Development of urease inhibitors considering halogen bondingPrincipal Investigator
- Principal Investigator
  
  Ishikawa Yoshinobu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Bioactive compounds from Mongolian traditional medicinal plants and their effects evaluations to living organisms using insect
- Principal Investigator
  
  MURATA Toshihiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Natural medicines
- Research Institution
  Tohoku Medical and Pharmaceutical University
SBDD targeting metalloenzyme RNA polymeraze of influenza virusPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA YOSHINOBU
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Shizuoka
Synthesis and analysis of telomere quadruplex DNA-binding porphyrins based on an electrostatic interaction modelPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Yoshinobu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Shizuoka
Predicition and verification for the structures and thermodynamic properties of telomeric DNA quadruplex/porphyrin complexesPrincipal Investigator
- Principal Investigator
  
  ISHIKAWA Yoshinobu
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  University of Shizuoka
  Kumamoto University
A Comprehensive Study on the Effects of Genetic Polymorphism on the Drug Metabolizing Activity of Human CYP
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
テロメアDNA四重鎖構造を安定化させテロメラーゼを阻害するポルフィリンの開発Principal Investigator
- Principal Investigator
  
  石川吉伸
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
Studies on the Signal Transduction Mechanism by Gas Sensor Proteins
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
Development of Porphyrin as a Molecular Cutter of Genes
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Kumamoto University
テロメア四重鎖DNAに作用する芳香族カチオン性ポルフィリンの開発Principal Investigator
- Principal Investigator
  
  石川吉伸
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
A STUDY ON DNA CLEAVAGE MECHANISM BY WATER-SOLUBLE PORPHYRINS
- Principal Investigator
  
  UNO Tadayuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Physical pharmacy
- Research Institution
  KUMAMOTO UNIVERSITY

[Book] in silico創薬におけるスクリーニングの高速化・高精度化技術2018
- Author(s)
  石川吉伸他計80名
- Total Pages
  540
- Publisher
  技術情報協会
- ISBN
  9784861046889
- Data Source
  KAKENHI-PROJECT-16K08199
[Journal Article] Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells.2020
- Author(s)
  Nasako H, Akizuki R, Takashina Y, Ishikawa Y, Shinoda T, Shirouzu M, Asai T, Matsunaga T, Endo S, Ikari A.
- Journal Title
  
  Biochim Biophys Acta Mol Cell Res.
  
  Volume: 1867 Issue: 4 Pages: 118642-118642
- DOI
  10.1016/j.bbamcr.2019.118642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-19K07792, KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H03373
[Journal Article] Impact of single nucleotide polymorphisms (R132Q and W120R) on the binding affinity and metabolic activity of CYP2C19 toward some therapeutically important substrates2020
- Author(s)
  Derayea SM, Tsujino H, Oyama Y, Ishikawa Y, Yamashita T, Uno T.
- Journal Title
  
  Xenobiotica
  
  Volume: 50 Issue: 12 Pages: 1510-1519
- DOI
  10.1080/00498254.2020.1786189
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07315
[Journal Article] Increase in toxicity of anticancer drugs by PMTPV, a claudin-1-binding peptide, mediated via down-regulation of claudin-1 in human lung adenocarcinoma A549 cells2020
- Author(s)
  Nasako, H., Takashina, Y., Eguchi, H., Ito, A., Ishikawa, Y., Matsunaga, T., Endo, S., Ikari, A
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 16 Pages: 5909-5909
- DOI
  10.3390/ijms21165909
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03373, KAKENHI-PROJECT-18K07315
[Journal Article] Total Synthesis of Sophoraflavanone H and Confirmation of Its Absolute Configuration2020
- Author(s)
  Murakami Haruka、Asakawa Tomohiro、Muramatsu Yoshihiro、Ishikawa Ryo、Hiza Aiki、Tsukaguchi Yuta、Tokumaru Yohei、Egi Masahiro、Inai Makoto、Ouchi Hitoshi、Yoshimura Fumihiko、Taniguchi Tohru、Ishikawa Yoshinobu、Kondo Mitsuru、Kan Toshiyuki
- Journal Title
  
  Organic Letters
  
  Volume: 22 Issue: 10 Pages: 3820-3824
- DOI
  10.1021/acs.orglett.0c01063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05460, KAKENHI-PROJECT-20K06946, KAKENHI-PROJECT-20K15958, KAKENHI-PROJECT-18K07315
[Journal Article] Isolation and evaluation of trypanocidal activity of sesquiterpenoids, flavonoids, and lignans in Artemisia sieversiana collected in Mongolia2020
- Author(s)
  Nurbek Stipan、Murata Toshihiro、Suganuma Keisuke、Ishikawa Yoshinobu、Buyankhishig Buyanmandakh、Kikuchi Takashi、Byambajav Tseesuren、Davaapurev Bekh-Ochir、Sasaki Kenroh、Batkhuu Javzan
- Journal Title
  
  Journal of Natural Medicines
  
  Volume: 74 Issue: 4 Pages: 750-757
- DOI
  10.1007/s11418-020-01429-2
- NAID
  40022344677
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16397, KAKENHI-PROJECT-18K07315
[Journal Article] Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse2019
- Author(s)
  Ashizawa T, Iizuka A, Tanaka E, Kondou R, Miyata H, Maeda C, Sugino T, Yamaguchi K, Ando T, Ishikawa Y, Ito M, Akiyama Y.
- Journal Title
  
  Biomed. Res.
  
  Volume: 40 Issue: 6 Pages: 243-250
- DOI
  10.2220/biomedres.40.243
- NAID
  130007761178
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2019-12-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-17K07209
[Journal Article] Concise Synthesis of TAN1251C2019
- Author(s)
  Nagasaka Y, Asakawa T, Shintaku S, Masuda A, Matsumura K, Inai M, Ishikawa Y, Egi M, Hamashima Y, Kan T.
- Journal Title
  
  HETEROCYCLES
  
  Volume: 99 Issue: 2 Pages: 1095-1116
- DOI
  10.3987/com-18-s(f)78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-19K05460, KAKENHI-PLANNED-17H06402, KAKENHI-PUBLICLY-18H04424, KAKENHI-PROJECT-17H03973
[Journal Article] Propolis components from stingless bees collected on South Sulawesi, Indonesia, and their xanthine oxidase inhibitory activity2019
- Author(s)
  Miyata R, Sahlan M, Ishikawa Y, Hashimoto H, Honda S, Kumazawa S
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 82 Issue: 2 Pages: 205-210
- DOI
  10.1021/acs.jnatprod.8b00541
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PUBLICLY-17H06014, KAKENHI-PROJECT-16H04755, KAKENHI-PROJECT-16H05113, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-16K08199, KAKENHI-PROJECT-18KK0165
[Journal Article] Acylated Lignans Isolated from Brachanthemum gobicum and Their Trypanocidal Activity2019
- Author(s)
  Odonbayar B, Murata T, Suganuma K, Ishikawa Y, Buyankhishig B, Batkhuu J, Sasaki K.
- Journal Title
  
  J. Nat. Prod
  
  Volume: 82 Issue: 4 Pages: 774-784
- DOI
  10.1021/acs.jnatprod.8b00670
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-16K18793
[Journal Article] Inhibitory Effects of Phenylpropanoid Derivatives from Oenanthe javanica on Antigen-stimulated Degranulation in RBL-2H3 Cells2019
- Author(s)
  Murata T, Katagiri T, Ishikawa Y, Abe M, Takahashi E, Iwahana R, Sakamoto Y, Sasaki K.
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 82 Issue: 6 Pages: 1518-1526
- DOI
  10.1021/acs.jnatprod.8b01054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07315
[Journal Article] Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp2019
- Author(s)
  Hara Kodai、Iida Nao、Tamafune Ryota、Ohashi Eiji、Sakurai Hitomi、Ishikawa Yoshinobu、Hishiki Asami、Hashimoto Hiroshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 4 Pages: 899-904
- DOI
  10.1074/jbc.ac119.011816
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-19K06613, KAKENHI-PROJECT-19K07792, KAKENHI-PROJECT-16H05840
[Journal Article] Investigation on drug-binding in heme pocket of CYP2C19 with UV-visible and resonance Raman spectroscopies2019
- Author(s)
  Derayea SM, Tsujino H, Oyama Y, Ishikawa Y, Yamashita T, Uno T.
- Journal Title
  
  Spectrochim. Acta A
  
  Volume: 209 Pages: 209-216
- DOI
  10.1016/j.saa.2018.10.045
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-16K08199
[Journal Article] Structural and Thermodynamic Basis of the Enhanced Interaction between Kinesin Spindle Protein Eg5 and STLC-type Inhibitors2018
- Author(s)
  Yokoyama Hideshi、Sawada Jun-ichi、Sato Kohei、Ogo Naohisa、Kamei Nanami、Ishikawa Yoshinobu、Hara Kodai、Asai Akira、Hashimoto Hiroshi
- Journal Title
  
  ACS Omega
  
  Volume: 3 Issue: 9 Pages: 12284-12294
- DOI
  10.1021/acsomega.8b00778
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-17K07316, KAKENHI-PROJECT-17K08366, KAKENHI-PROJECT-18K07315, KAKENHI-PUBLICLY-17H06014, KAKENHI-PROJECT-16H04755, KAKENHI-PROJECT-16H05113, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-16K08199
[Journal Article] Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment maintaining phosphoprotein (CAMP)2017
- Author(s)
  Hara K, Taharazako S, Ikeda M, Fujita H, Mikami Y, Kikuchi S, Hishiki A, Yokoyama H, Ishikawa Y, Kanno S, Tanaka K, Hashimoto H.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 43 Pages: 17658-17667
- DOI
  10.1074/jbc.m117.804237
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08199, KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-17K07316, KAKENHI-PUBLICLY-16H01296, KAKENHI-PUBLICLY-17H06014, KAKENHI-PROJECT-15H04368, KAKENHI-PROJECT-16H04755, KAKENHI-PROJECT-16H05113, KAKENHI-PROJECT-16H05840
[Journal Article] Mechanistic Insight into Weak Base-Catalyzed Generation of Carbon Monoxide from Phenyl Formate and Its Application to Catalytic Carbonylation at Room Temperature without Use of External Carbon Monoxide Gas2017
- Author(s)
  Konishi Hideyuki、Matsubara Mika、Mori Keisuke、Tokiwa Takaki、Arulmozhiraja Sundaram、Yamamoto Yuta、Ishikawa Yoshinobu、Hashimoto Hiroshi、Shigeta Yasuteru、Tokiwa Hiroaki、Manabe Kei
- Journal Title
  
  Advanced Synthesis & Catalysis
  
  Volume: 359 Issue: 20 Pages: 3592-3601
- DOI
  10.1002/adsc.201700751
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17KT0010, KAKENHI-PROJECT-16K08199, KAKENHI-PUBLICLY-17H06014, KAKENHI-PROJECT-15H04634, KAKENHI-PROJECT-16H04755, KAKENHI-PROJECT-16H05113, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-15K18834
[Journal Article] Total Synthesis of TAN1251C via Diastereoselective Construction of the Azaspiro Skeleton2017
- Author(s)
  Nagasaka Y, Shintaku S, Matsumura K, Masuda A, Asakawa T, Inai M, Egi M, Hamashima Y, Ishikawa Y, Kan T.
- Journal Title
  
  Organic Letters
  
  Volume: 19 Issue: 14 Pages: 3839-3842
- DOI
  10.1021/acs.orglett.7b01718
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08199, KAKENHI-PROJECT-17K15424, KAKENHI-PUBLICLY-16H01160, KAKENHI-PROJECT-17H03973
[Journal Article] Crystal structure of 7-iodo-4-oxo-4H-chromene-3-carbaldehyde2016
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst. sec. E.
  
  Volume: E72 Issue: 12 Pages: 1724-1727
- DOI
  10.1107/s2056989016016972
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08199
[Journal Article] Abietane-type diterpenoids from the roots of Caryopteris mongolica2016
- Author(s)
  Toshihiro Murata, Yoshinobu Ishikawa, Erdenebileg Saruul, Erdenechimeg Selenge, Kenroh Sasaki, Kaoru Umehara, Fumihiko Yoshizaki, Javzan Batkhuu
- Journal Title
  
  Phytochemistry
  
  Volume: 130 Pages: 152-158
- DOI
  10.1016/j.phytochem.2016.05.011
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860068, KAKENHI-PROJECT-16K08199
[Journal Article] Structural Basis of New Allosteric Inhibition in Kinesin Spindle Protein Eg52015
- Author(s)
  Yokoyama H, Sawada J, Katoh S, Matsuno K, Ogo N, Ishikawa Y, Hashimoto H, Fujii S, Asai A.
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 10 Issue: 4 Pages: 1128-1136
- DOI
  10.1021/cb500939x
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141, KAKENHI-PUBLICLY-25121728, KAKENHI-PROJECT-25291017, KAKENHI-PROJECT-26440034, KAKENHI-PROJECT-26460150
[Journal Article] 7-Chloro-4-oxo-4H-chromene-3- carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 8 Pages: o831-o831
- DOI
  10.1107/s1600536814014925
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Chloro-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 5 Pages: o514-o514
- DOI
  10.1107/s1600536814007119
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Computational Prediction of Diastereomeric Separation Behavior of Fluorescent o-Phthalaldehyde Derivatives of Amino Acids.2014
- Author(s)
  Todoroki K, Nakano T, Watanabe H, Min JZ, Inoue K, Ishikawa Y, Toyo’oka T.
- Journal Title
  
  Anal. Sci.
  
  Volume: 30 Pages: 865-870
- NAID
  130004687412
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] (E)-3,4,5-Trimethoxy-N’-[(4-oxo-4H-chromen-3-yl)methylidene]benzohydrazide2014
- Author(s)
  Ishikawa Y., Watanabe K.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 4 Pages: o472-o472
- DOI
  10.1107/s1600536814005753
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Iodo-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 7 Pages: o744-o744
- DOI
  10.1107/s1600536814012471
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Crystal structure of (3,5-dibromo- 2-hydroxyphenyl){1-[(naphthalen-1-yl)- carbonyl]-1H-pyrazol-4-yl}methanone2014
- Author(s)
  Ishikawa Y. Motohashi Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 9 Pages: o1033-o1033
- DOI
  10.1107/s1600536814018601
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Fluoro-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 5 Pages: o583-o583
- DOI
  10.1107/s1600536814008502
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Diethyl 7,7'-dichloro-4-oxo-4H-[1,4'-biquinoline]-3,3'-dicarboxylate2014
- Author(s)
  Ishikawa Y., Sugisawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 6 Pages: o655-o655
- DOI
  10.1107/s1600536814010320
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Chloro-7-methyl-4-oxo-4H-chromene- 3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 7 Pages: o804-o804
- DOI
  10.1107/s1600536814014226
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Chloro-7-fluoro-4-oxo-4H-chromene- 3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 7 Pages: o825-o825
- DOI
  10.1107/s1600536814014706
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] (E)-4-Methoxy-N00-[(6-methyl-4-oxo-4Hchromen- 3-yl)methylidene]benzohydrazide monohydrate2014
- Author(s)
  Ishikawa Y., Watanabe K.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 7 Pages: o784-o784
- DOI
  10.1107/s1600536814013713
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Crystal structure of 7-bromo-4-oxo-4Hchromene- 3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 9 Pages: o996-o996
- DOI
  10.1107/s1600536814018108
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Ethyl 8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate2014
- Author(s)
  Ishikawa Y., Yoshida N.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 6 Pages: o719-o719
- DOI
  10.1107/s1600536814011854
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] (E)-3,4,5-Trimethoxy-N00-[(6-methoxy-4- oxo-4H-chromen-3-yl)methylidene] benzohydrazide monohydrate2014
- Author(s)
  Ishikawa Y., Watanabe K.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 8 Pages: o832-o832
- DOI
  10.1107/s1600536814014937
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 8-Fluoro-4-oxo-4H-chromene-3- carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 7 Pages: o774-o774
- DOI
  10.1107/s1600536814013208
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 3-Acetyl-2-fluoro-6H-benzo[c]chromen-6-one2014
- Author(s)
  Ishikawa Y., Suzuki T., Yoshida N.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 4 Pages: o470-o471
- DOI
  10.1107/s1600536814005959
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 8-Chloro-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 7 Pages: o743-o743
- DOI
  10.1107/s1600536814012483
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6,8-Dibromo-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 4 Pages: o439-o439
- DOI
  10.1107/s1600536814005327
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6,8-Diiodo-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 5 Pages: o536-o536
- DOI
  10.1107/s1600536814006904
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] (E )-4-Methyl-N-[(4-oxo-4H-chromen-3-yl)methylidene] benzohydrazide2014
- Author(s)
  Ishikawa Y., Watanabe K.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 5 Pages: o565-o565
- DOI
  10.1107/s1600536814008113
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Bromo-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 5 Pages: o555-o555
- DOI
  10.1107/s160053681400796x
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6-Chloro-8-nitro-4-oxo-4H-chromene-3-carbaldehyde2014
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E70 Issue: 5 Pages: o547-o547
- DOI
  10.1107/s1600536814007788
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 3-[(E)-(Benzyliminiumyl)methyl]-6,8-dichloro-2H-chromen-4-olate2013
- Author(s)
  Ishikawa Y., Motohashi Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E69 Issue: 8 Pages: o1225-o1225
- DOI
  10.1107/s1600536813018072
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Ethyl (Z)-4-(4-ethoxy-1-hydroxy-3,4-dioxobut-1-en-1-yl)-[1,1-biphenyl]-3-carboxylate2013
- Author(s)
  Ishikawa Y., Ugai A.
- Journal Title
  
  Acta Cryst.
  
  Volume: E69 Issue: 8 Pages: o1231-o1231
- DOI
  10.1107/s1600536813018503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] A Script for Automated 3-Dimentional Structure Generation and Conformer Search from 2-Dimentional Chemical Drawing2013
- Author(s)
  Ishikawa Y.
- Journal Title
  
  Bioinformation
  
  Volume: 9 Issue: 19 Pages: 988-992
- DOI
  10.6026/97320630009988
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] (E)-6,8-Dichloro-3-{[(naphthalen-1-ylmethyl)iminiumyl]methyl}-2H-chromen-4-olate2013
- Author(s)
  Ishikawa Y., Motohashi Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E69 Issue: 8 Pages: o1226-o1226
- DOI
  10.1107/s1600536813018084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 2-Hydroxyisoquinoline-1,3(2H,4H)-dione2013
- Author(s)
  Ishikawa Y., Matsuo S.
- Journal Title
  
  Acta Cryst.
  
  Volume: E69 Issue: 8 Pages: o1312-o1312
- DOI
  10.1107/s1600536813019843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 2-(Benzyloxy)isoquinoline-1,3(2H,4H)-dione2013
- Author(s)
  Ishikawa Y., Matsuo S.
- Journal Title
  
  Acta Cryst.
  
  Volume: E69 Issue: 8 Pages: o1311-o1311
- DOI
  10.1107/s1600536813019934
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] (E)-3-{[([1,1-Biphenyl]-3-ylmethyl)iminiumyl]methyl}-6,8-dichloro-2H-chromen-4-olate2013
- Author(s)
  Ishikawa Y., Motohashi Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E69 Issue: 9 Pages: o1448-o1448
- DOI
  10.1107/s160053681302285x
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 4'-Acetyl-3''-carbamoyl-[1,1':3',1''-terphenyl]-2-carboxylic acid2013
- Author(s)
  Ishikawa Y., Yoshida N., Suzuki T.
- Journal Title
  
  Acta Cryst.
  
  Volume: E69 Issue: 10 Pages: o1596-o1596
- DOI
  10.1107/s1600536813026482
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] 6,8-Dichloro-4-oxochromene-3-carbaldehyde2013
- Author(s)
  Ishikawa Y., Motohashi Y.
- Journal Title
  
  Acta Cryst.
  
  Volume: E69 Issue: 9 Pages: o1416-o1416
- DOI
  10.1107/s1600536813022228
- Data Source
  KAKENHI-PROJECT-24590141
[Journal Article] Regiocomplementary Cycloaddition Reactions of Boryl- and Silylbenzynes with 1, 3-Dipoles : Selective Synthesis of Benzo-Fused Azole Derivatives2013
- Author(s)
  Akira Takagi, Takashi Ikawa, Alcira Takagi, Masahiko Goto, Yuya Aoyama, Yoshinobu Ishikawa, Yuji Itoh, Hiroaki Tokiwa, and Shuji Akai
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 78 Issue: 7 Pages: 2965-2983
- DOI
  10.1021/jo302802b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10892, KAKENHI-PROJECT-22590039, KAKENHI-PROJECT-23790017, KAKENHI-PROJECT-24590141, KAKENHI-PROJECT-25460018, KAKENHI-PROJECT-25460157
[Journal Article] Novel candesartan derivatives as indoleamine 2, 3-dioxygenase inhibitors2012
- Author(s)
  Matsuno K, Yamazaki H, Isaka Y, takai K, Unno Y, Ogo N, Ishikawa Y, Fujii S, Takikawa O, Asai A
- Journal Title
  
  Med. Chem. Comm.
  
  Volume: 3 Issue: 4 Pages: 475-479
- DOI
  10.1039/c2md00278g
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590353, KAKENHI-PROJECT-22590039, KAKENHI-PROJECT-24590141
[Journal Article] ortho-Selective Nucleophilic Addition of Primary Amines to Silylbenzynes : Synthesis of 2-Silylanilines2011
- Author(s)
  Ikawa T., Nishiyama T., Shigeta T., Mohri S., Morita S., Takayanagi S., Terauchi Y., Morikawa Y., Takagi A., Ishikawa Y., Fujii S., Kita Y. Akai S.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 50 Pages: 5674-5677
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590118
[Journal Article] Binding mode prediction and inhibitor design of anti-influenza virus diketo acids targeting metalloenzyme RNA polymerase by molecular docking2011
- Author(s)
  Ishikawa Y. & Fujii S.
- Journal Title
  
  Bioinformation
  
  Volume: 6 Pages: 221-225
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590118
[Journal Article] Ortho-selective nucleophilicaddition of primary amines tosilylbenzynes: Synthesis of 2-silylanilines2011
- Author(s)
  Y . Kita et al.
- Journal Title
  
  Angew . Chem., Int. Ed.
  
  Volume: 50 Issue: 25 Pages: 5674-5677
- DOI
  10.1002/anie.201100360
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249002, KAKENHI-PROJECT-21590118, KAKENHI-PROJECT-23790017
[Journal Article] 1,1',1',1'-[Porphyrin-5,10,15,20-tetrayltetrakis(3,1-phenylenemethylene)]tetraquinolinium Tetrabromide2010
- Author(s)
  Ishikawa Y., Yamashita T., Fujii S., Uno T.
- Journal Title
  
  Molbank
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590118
[Journal Article] 1, 1', 1'', 1'''-[Porphyrin-5, 10, 15, 20-tetrayltetrakis(3, 1-phenylenemethylene)] tetraquinolinium Tetrabromide2010
- Author(s)
  Ishikawa Y., Yamashita T., Fujii S., Uno T.
- Journal Title
  
  Molbank
  
  Volume: 704
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590118
[Journal Article] Zinc(II)-5, 10, 15, 20-tetrakis(a-pyridino-m-tolyl)porphyrin Tetrabromide2009
- Author(s)
  Ishikawa Y., Yamashita T., Fujii S., Uno T.
- Journal Title
  
  Molbank
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590118
[Journal Article] Zinc(II)-5, 10, 15, 20-tetrakis(a-pyridino-m-tolyl) p orphyrin Tetrabromide2009
- Author(s)
  Ishikawa Y., Yamashita T., Fujii S., Uno T.
- Journal Title
  
  Molbank
  
  Volume: 637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590118
[Journal Article] Binding of Cationic Bis-porphyrins Linked with p-or m- Xylylenediamine and Their Zinc(II)Complexes to Duplex DNA.2008
- Author(s)
  Yoshinobu Ishikawa, Naoki Yamakawa, Tadayuki Uno.
- Journal Title
  
  Molecules 13
  
  Pages: 3117-3128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Molecular docking study of binding of TMPyP4 to a bimolecular human telomeric G-quadruplex.2008
- Author(s)
  Yoshinobu Ishikawa, Satoshi Fujii.
- Journal Title
  
  Nucleic Acids Symp. Ser. 52
  
  Pages: 173-174
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Molecular docking study of binding of TMPyP4 to a bimolecular human telomeric G-quadruplex2008
- Author(s)
  Ishikawa Y, Fujii S
- Journal Title
  
  Nucleic Acids Symp. Ser 52
  
  Pages: 173-174
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Binding of Cationic Bis-porphyrins Linked with p- or m- Xylylenediamine and Their Zinc(II) Complexes to Duplex DNA2008
- Author(s)
  Ishikawa Y, Yamakawa N, Uno T
- Journal Title
  
  Molecules 13
  
  Pages: 3117-3128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Molecular Docking of porphyrins with cationic limbs on Intramolecular G-quadruplex2007
- Author(s)
  Ishikawa Y, Higashi E, Morioka H
- Journal Title
  
  Nucleic Acids Symp. Ser 51
  
  Pages: 247-248
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Molecular Docking of porphyrins with cationic limbs on Intramolecular G-quadruplex2007
- Author(s)
  Ishikawa Y., Higashi E. and Morioka H.
- Journal Title
  
  Nucleic Acids Symp. Ser. 51
  
  Pages: 247-248
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Synthetic Control of Interchromophoric Interaction in Cationic Bis-porphyrins toward Efficient DN.2007
- Author(s)
  Ishikawa Y., Yamakawa N. and Uno T.
- Journal Title
  
  Bioorg. Med. Chem. 15
  
  Pages: 5230-5238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Synthetic Control of Interchromophoric Interaction in Cationic Bis-porphyrins toward Efficient DNA Photocleavage with Singlet Oxygen Production in Aqueous Solution2007
- Author(s)
  Ishikawa Y, Yamakawa N and Uno T
- Journal Title
  
  Bioorg. Med. Chem 15
  
  Pages: 5230-5238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Molecular modeling of Anti-parallel G-quadruplex DNA/TMPyP Complexes2006
- Author(s)
  Ishikawa Y, Tomisugi Y, Uno T
- Journal Title
  
  Nucleic Acids Symp. Ser 50
  
  Pages: 331-332
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] Molecular modeling of Anti-parallel G-quadruplex DNA/TMPyP Complexes2006
- Author(s)
  Yoshinobu Ishikawa, Yoshikazu Tomisugi, Tadayuki Uno
- Journal Title
  
  Nucleic Acids Symp.Ser. 50
  
  Pages: 331-332
- Data Source
  KAKENHI-PROJECT-18590098
[Journal Article] The C-Helix in CooA Rolls upon CO Binding to Ferrous Heme2004
- Author(s)
  Taku Yamashita, Yohei Hoashi, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Tadayuki Uno
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 47320-47325
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Roles of Heme Axial Ligands in the Regulation of CO Binding to CooA2004
- Author(s)
  Taku Yamashita, Yohei Hoashi, Kimiko Watanabe, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Tadayuki Uno
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 21394-21400
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Residues in the Distal Heme Pocket of Neuroglobin : Implications for the Multiple Ligand Binding Steps2004
- Author(s)
  Tadayuki Uno, Daisuke Ryu, Hiroko Tsutsumi, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Anthony J.Wilkinson, Hideaki Sato, Takashi Hayashi
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 5886-5893
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Journal Article] Inversion of Axial Coordination in Myoglobin to Create a "Proximal" Ligand Binding Pocket2003
- Author(s)
  Tadayuki Uno, Rikiharu Sakamoto, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Anthony J.Wilkinson
- Journal Title
  
  Biochemistry 42
  
  Pages: 10191-10199
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390015
[Patent] PD-1及び/又はPD-L1の阻害剤2021
- Inventor(s)
  秋山靖人、芦澤忠、飯塚明、井上謙吾、安藤隆幸、石川吉伸
- Industrial Property Rights Holder
  静岡県、PVPSO、静岡県公立大学法人
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-045476
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-18K07315
[Patent] 特許権2018
- Inventor(s)
  山口健、石川吉伸、他
- Industrial Property Rights Holder
  山口健、石川吉伸、他
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Acquisition Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-18K07315
[Patent] がんの発症リスクの有無を判定する方法2017
- Inventor(s)
  山口健、石川吉伸、他計14名
- Industrial Property Rights Holder
  山口健、石川吉伸、他計14名
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Acquisition Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16K08199
[Patent] 新規抗がん薬2016
- Inventor(s)
  益谷美都子、石川吉伸、他計14名
- Industrial Property Rights Holder
  益谷美都子、石川吉伸、他計14名
- Industrial Property Rights Type
  特許
- Filing Date
  2016
- Acquisition Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-16K08199
[Patent] 特許権2016
- Inventor(s)
  益谷美都子、石川吉伸，他
- Industrial Property Rights Holder
  益谷美都子、石川吉伸，他
- Industrial Property Rights Type
  特許
- Filing Date
  2016-10-27
- Overseas
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] RHINOが結合したRAD9-RAD1-HUSの結晶構造によって明らかになったDNAクランプの新規な分子間相互作用2020
- Author(s)
  飯田奈央、原幸大、櫻井ひとみ、石川吉伸、菱木麻美、橋本博
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] チェックポイント経路の活性化に関わる9-1-1とRHINOの相互作用解析2020
- Author(s)
  玉舟亮太、飯田奈央、原幸大、櫻井ひとみ、石川吉伸、大橋英治、菱木麻美、橋本博
- Organizer
  2019年度量子ビームサイエンスフェスタ
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] Interaction analysis between RAD9-RAD1-HUS1 heterotrimer and RHINO in ATR-CHK1 checkpoint pathway2019
- Author(s)
  Ryota Tamafune, Nao Iida, Kodai Hara, Hitomi Sakurai, Yoshinobu Ishikawa, Eiji Ohashi, Asami Hishiki, Hiroshi Hashimoto
- Organizer
  第24回静岡健康・長寿学術フォーラム
- Data Source
  KAKENHI-PROJECT-19K07792
[Presentation] 細胞周期チェックポイントに関わる9-1-1とRHINOの相互作用解析2019
- Author(s)
  玉舟亮太、飯田奈央、原幸大、櫻井ひとみ、石川吉伸、大橋英治、菱木麻美、橋本博
- Organizer
  第8回食品薬学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] ATR-Chk1経路を担うcheckpoint clamp複合体の構造解析2019
- Author(s)
  原幸大、飯田奈央、玉舟亮太、櫻井ひとみ、石川吉伸、大橋英治、菱木麻美、橋本博
- Organizer
  第25回DNA複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 細胞周期チェックポイントに関わる9-1-1とRHINOの複合体のX線結晶構造解析2019
- Author(s)
  飯田奈央、原幸大、櫻井ひとみ、菱木麻美、石川吉伸、橋本博
- Organizer
  日本結晶学会2019年度年会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] ATR-Chk1経路を担うcheckpoint clamp複合体の構造解析2019
- Author(s)
  原幸大、飯田奈央、玉舟亮太、櫻井ひとみ、石川吉伸、大橋英治、菱木麻美、橋本博
- Organizer
  第25回DNA複製・組換え・修復ワークショップ
- Data Source
  KAKENHI-PROJECT-19K07792
[Presentation] 周期チェックポイントに関わる9-1-1とRHINOの相互作用解析を目的とした試料調製2019
- Author(s)
  玉舟亮太、飯田奈央、原幸大、櫻井ひとみ、石川吉伸、大橋英治、菱木麻美、橋本博
- Organizer
  第17回次世代を担う若手のためのフィジカル・ファーマフォーラム
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 細胞周期チェックポイントに関わる9-1-1とRHINOのゲルろ過カラムを用いた相互作用解析2019
- Author(s)
  玉舟亮太、飯田奈央、原幸大、櫻井ひとみ、石川吉伸、大橋英治、菱木麻美、橋本博
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2019
- Data Source
  KAKENHI-PROJECT-19K07792
[Presentation] 細胞周期チェックポイントに関わる9-1-1とRHINOの複合体のX線結晶構造2019
- Author(s)
  飯田奈央、原幸大、櫻井ひとみ、菱木麻美、石川吉伸、橋本博
- Organizer
  日本結晶学会2019年度年会
- Data Source
  KAKENHI-PROJECT-19K07792
[Presentation] 細胞周期チェックポイントに関わる9-1-1とRHINOのゲルろ過カラムを用いた相互作用解析2019
- Author(s)
  玉舟亮太、飯田奈央、原幸大、櫻井ひとみ、石川吉伸、大橋英治、菱木麻美、橋本博
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2019
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 新規1,4’-ビキノリン誘導体の創製とその合成中間体の結晶中で観測される酸素結合2019
- Author(s)
  和泉大輝、速水勇貴、吉田奈々子、橋本博、石川吉伸
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] ハロゲン化クロモンのウレアーゼ阻害能2019
- Author(s)
  青木広樹、杉澤康弘、原幸大、菱木麻美、橋本博、石川吉伸
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 細胞周期チェックポイントに関わる9-1-1とRHINOの相互作用解析2019
- Author(s)
  玉舟亮太、飯田奈央、原幸大、櫻井ひとみ、石川吉伸、大橋英治、菱木麻美、橋本博
- Organizer
  第8回食品薬学シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07792
[Presentation] DNA損傷チェックポイントの活性化を担うチェックポイントクランプ複合体の構造解析2019
- Author(s)
  原幸大、飯田奈央、玉舟亮太、櫻井ひとみ、石川吉伸、大橋英治、菱木麻美、橋本博
- Organizer
  第37回染色体ワークショップ
- Data Source
  KAKENHI-PROJECT-19K07792
[Presentation] DNA損傷チェックポイントの活性化を担うチェックポイントクランプ複合体の構造解析2019
- Author(s)
  原幸大、飯田奈央、玉舟亮太、櫻井ひとみ、石川吉伸、大橋英治、菱木麻美、橋本博
- Organizer
  第37回染色体ワークショップ
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] ノビレチン類似体の簡便な合成と腫瘍細胞増殖阻害活性2019
- Author(s)
  速水勇貴、橋本博、石川吉伸
- Organizer
  第8回食品薬学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] ノビレチン類似体の簡便な合成と腫瘍細胞増殖阻害活性2019
- Author(s)
  速水勇貴、橋本博、石川吉伸
- Organizer
  第8回食品薬学シンポジウム
- Data Source
  KAKENHI-PROJECT-19K07792
[Presentation] Interaction analysis between RAD9-RAD1-HUS1 heterotrimer and RHINO in ATR-CHK1 checkpoint pathway2019
- Author(s)
  Ryota Tamafune, Nao Iida, Kodai Hara, Hitomi Sakurai, Yoshinobu Ishikawa, Eiji Ohashi, Asami Hishiki, Hiroshi Hashimoto
- Organizer
  第24回静岡健康・長寿学術フォーラ
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 周期チェックポイントに関わる9-1-1とRHINOの相互作用解析を目的とした試料調製2019
- Author(s)
  玉舟亮太、飯田奈央、原幸大、櫻井ひとみ、石川吉伸、大橋英治、菱木麻美、橋本博
- Organizer
  第17回次世代を担う若手のためのフィジカル・ファーマフォーラム
- Data Source
  KAKENHI-PROJECT-19K07792
[Presentation] 相同組換えの抑制に関わるPARIの調製と結晶化条件の探索2018
- Author(s)
  松本貴宏、原幸大、田原迫奨大、菱木麻美、石川吉伸、橋本博
- Organizer
  PPF2018
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 1,4'-ビキノリン合成で見出された酸素結合2018
- Author(s)
  和泉大輝、速水勇貴、吉田奈々子、橋本博、石川吉伸
- Organizer
  日本病院薬剤師会東海ブロック日本薬学会東海支部合同学術大会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 相同組換えの抑制に関わるPARIの調製と結晶化条件の探索2018
- Author(s)
  松本貴宏、原幸大、田原迫奨大、菱木麻美、石川吉伸、橋本博
- Organizer
  第64回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] ハロゲン化クロモンのウレアーゼ阻害能2018
- Author(s)
  青木広樹、杉澤康弘、原幸大、菱木麻美、橋本博、石川吉伸
- Organizer
  日本病院薬剤師会東海ブロック日本薬学会東海支部合同学術大会
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 細胞周期チェックポイントに関わる9-1-1複合体の調製と生化学的解析2018
- Author(s)
  櫻井ひとみ、原幸大、内藤麻里奈、菱木麻美、石川吉伸、横山英志、橋本博
- Organizer
  第64回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 新規1,4’-ビキノリン誘導体の創製とその合成中間体の結晶中で観測される酸素結合2018
- Author(s)
  和泉大輝、速水勇貴、吉田菜々子、橋本博、石川吉伸
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 細胞周期チェックポイントに関わる9-1-1複合体の調製と生化学的解析2018
- Author(s)
  櫻井ひとみ、原幸大、内藤麻里奈、菱木麻美、石川吉伸、横山英志、橋本博
- Organizer
  第64回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] ポリADPリボース集積活性を有する抗がん剤候補MO2455の同定と構造活性相関2018
- Author(s)
  松野研司、橋本知子、小林寛幸、大野修、イスラムラフィクル、大川原正、高村岳樹、佐々木由香、小野寺貴恵、藤森浩彰、小泉史朗、下山達、澤田武志、秋元茉莉、石川吉伸、入江徹美、井上謙吾、益谷美都子
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 1,4'-ビキノリン合成で見出された酸素結合2018
- Author(s)
  和泉大輝、速水勇貴、吉田奈々子、橋本博、石川吉伸
- Organizer
  日本病院薬剤師会東海ブロック日本薬学会東海支部合同学術大会
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 細胞周期チェックポイントに関わる9-1-1複合体の調製と生化学的解析2018
- Author(s)
  櫻井ひとみ、原幸大、内藤麻里奈、菱木麻美、石川吉伸、横山英志、橋本博
- Organizer
  PPF2018
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] ハロゲン化クロモンのウレアーゼ阻害能2018
- Author(s)
  青木広樹、杉澤康弘、原幸大、菱木麻美、橋本博、石川吉伸
- Organizer
  日本病院薬剤師会東海ブロック日本薬学会東海支部合同学術大会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 相同組換えの抑制に関わるPARIの調製と結晶化条件の探索2018
- Author(s)
  松本貴宏、原幸大、田原迫奨大、菱木麻美、石川吉伸、橋本博
- Organizer
  PPF2018
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] ハロゲン化クロモンのウレアーゼ阻害能2018
- Author(s)
  青木広樹、杉澤康弘、原幸大、菱木麻美、橋本博、石川吉伸
- Organizer
  日本薬学会第139回年会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 細胞周期チェックポイントに関わる9-1-1複合体の調製と生化学的解析2018
- Author(s)
  櫻井ひとみ、原幸大、内藤麻里奈、菱木麻美、石川吉伸、横山英志、橋本博
- Organizer
  PPF2018
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] ポリADPリボース集積活性を有する抗がん剤候補MO2455の同定と構造活性相関2018
- Author(s)
  松野研司、橋本知子、小林寛幸、大野修、イスラムラフィクル、大川原正、高村岳樹、佐々木由香、小野寺貴恵、藤森浩彰、小泉史朗、下山達、澤田武志、秋元茉莉、石川吉伸、入江徹美、井上謙吾、益谷美都子
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 相同組換えの抑制に関わるPARIの調製と結晶化条件の探索2018
- Author(s)
  松本貴宏、原幸大、田原迫奨大、菱木麻美、石川吉伸、橋本博
- Organizer
  第64回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] テンプレートスイッチに関わるZRANB3のAlkB homolog 2 PCNA-binding motif (APIM)とPCNAの複合体の構造基盤と相互作用機構の解明2017
- Author(s)
  原幸大、内田雅之、田形梨紗、横山英志、石川吉伸、菱木麻美、橋本博
- Organizer
  第24回DNA複製・組換え・修復ワークショップ（岐阜）
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 細胞分裂におけるMAD2L2-CAMP複合体の構造と相互作用機構の解明2017
- Author(s)
  原幸大、田原迫奨大、菱木麻美、石川吉伸、菅野新一郎、田中耕三、橋本博
- Organizer
  第63回日本薬学会東海支部総会・大会（岐阜）
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] In silico screening系を用いたPD-1/PD-L1阻害活性を持つ低分子化合物の同定2017
- Author(s)
  秋山靖人、石川吉伸、安藤隆幸、井上謙吾
- Organizer
  日本がん分子標的治療学会第1回SNワークショップ
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] Crystallographic structure of Mad2L2-CAMP complex, a regulator of kinetochore-microtubule attachment2017
- Author(s)
  Kodai Hara, Shota Taharazako, Asami Hishiki, Yoshinobu Ishikawa, Shin-ichiro Kanno, Kozo Tanaka, Hiroshi Hashimoto
- Organizer
  SMC proteins 2017 “chromosomal organizers from bacteria to human”（Yamagata）
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 染色体分配に関わるMAD2L2-CAMP複合体の構造基盤と相互作用機構の解明2017
- Author(s)
  原幸大、田原迫奨大、池田真教、藤田拡樹、三上嘉子、菊池壮太郎、菱木麻美、横山英志、石川吉伸、菅野新一郎、田中耕三、橋本博
- Organizer
  第35回染色体ワークショップ（愛知）
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] PCNAとHLAペプチドの結晶学的研究2017
- Author(s)
  鈴木麻里子、原幸大、菱木麻美、石川吉伸、橋本博
- Organizer
  第63回日本薬学会東海支部総会・大会（岐阜）
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 染色体分配に関わるMad2L2-CAMP複合体のX線結晶構造解析2016
- Author(s)
  田原迫奨大、原幸大、菱木麻美、石川吉伸、菅野新一郎、田中耕三、橋本博
- Organizer
  日本病院薬剤師東海ブロック　日本薬学会東海支部合同学術大会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] テンプレートスイッチに関わるZranb3 PIPとPCNAの構造機能解析2016
- Author(s)
  内田雅之、原幸大、田形梨紗、菱木麻美、石川吉伸、横山英志、橋本博
- Organizer
  第62回日本薬学会東海支部総会・大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 紫外線高感受性症候群責任因子UVSSAのVHSドメインのX線結晶構造解析2016
- Author(s)
  松尾和香、橋本優子、原幸大、菱木麻美、石川吉伸、郭朝万、中沢由華、唐田清伸、荻明男、橋本博
- Organizer
  日本病院薬剤師東海ブロック　日本薬学会東海支部合同学術大会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 紫外線高感受性症候群責任因子UVSSAのVHSドメインの構造解析2016
- Author(s)
  松尾和香、橋本優子、原幸大、菱木麻美、石川吉伸、郭朝万、中沢由華、唐田清伸、荻明男、橋本博
- Organizer
  日本結晶学会平成28年度年会
- Place of Presentation
  水戸
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] 染色体分配に関わるMad2L2-CAMP複合体のX線結晶構造解析2016
- Author(s)
  田原迫奨大、原幸大、菱木麻美、石川吉伸、菅野新一郎、田中耕三、橋本博
- Organizer
  日本結晶学会平成28年度年会
- Place of Presentation
  水戸
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] オリゴペプチド結合タンパク質の構造解析2016
- Author(s)
  亀井七海、横山英志、小西佳史郎、原幸大、石川吉伸、松井郁夫、Patrick Forterre、橋本博
- Organizer
  第62回日本薬学会東海支部総会・大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] テンプレートスイッチに関わるZRANB3とPCNAの相互作用解析2016
- Author(s)
  内田雅之、原幸大、田形梨紗、菱木麻美、石川吉伸、横山英志、橋本博
- Organizer
  日本結晶学会平成28年度年会
- Place of Presentation
  水戸
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K08199
[Presentation] Novel cysteine derivatives for the next generation anticancer agents acting on KSP2014
- Author(s)
  Naohisa Ogo, Jun-ichi Sawada, Yoshinobu Ishikawa, Kenji Matsuno, Akihiro Hashimoto, Akira Asai
- Organizer
  25th EORTC-NCI-AACR symposium Molecular targets and cancer therapeutics
- Place of Presentation
  バルセロナ
- Year and Date
  2014-11-20
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] 新規KSP阻害剤の創製 ‐システイン誘導体の合成と構造活性相関‐2014
- Author(s)
  小郷尚久、石川吉伸、松野研司、澤田潤一、橋本章弘、浅井章良
- Organizer
  第32回メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] 量子化学計算に基づくアミノ酸ジアステレオマーの光学分離メカニズムの考察2014
- Author(s)
  中野達基、轟木堅一郎、石川吉伸、閔俊哲、井之上浩一、豊岡利正
- Organizer
  第74回分析化学討論会
- Place of Presentation
  郡山
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] 新規システイン誘導体のKSP阻害に基づく次世代抗がん剤探索研究2014
- Author(s)
  小郷尚久、澤田潤一、石川吉伸、松野研司、橋本章弘、浅井章良
- Organizer
  日本ケミカルバイオロジー学会第9回年会
- Place of Presentation
  大阪
- Year and Date
  2014-06-12
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] ATP拮抗型キネシンEg5阻害剤の阻害様式における構造的基盤2014
- Author(s)
  横山英志、澤田潤一、加藤詩織、松野研司、小郷尚久、石川吉伸、橋本博、藤井敏、浅井章良
- Organizer
  日本ケミカルバイオロジー学会第9回年会
- Place of Presentation
  大阪
- Year and Date
  2014-06-12
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] 塩基によるギ酸エステルの分解反応の計算化学的解析2014
- Author(s)
  森敬介、小西英之、石川吉伸、橋本博、眞鍋敬
- Organizer
  日本薬学会東海支部大会
- Place of Presentation
  鈴鹿
- Year and Date
  2014-07-05
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] 理論化学計算に基づくアミノ酸ジアステレオマー誘導体の光学分離メカニズムの考察2013
- Author(s)
  中野達基、轟木堅一郎、石川吉伸、閔俊哲、井之上浩一、豊岡利正
- Organizer
  新アミノ酸分析研究会　第3回学術講演会
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] ギ酸エステルの分解による一酸化炭素生成反応の計算化学的解析2013
- Author(s)
  森敬介、小西英之、石川吉伸、橋本博、眞鍋敬
- Organizer
  第44回中部化学関係学協会支部連合秋季大会
- Place of Presentation
  浜松市
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] インフルエンザウィルスの含金属エンドヌクレアーゼを阻害するアリールジケト酸のSB&CADD2013
- Author(s)
  石川吉伸、鵜飼淳、鈴木孝史、石垣範行、尾崎公英、横山英志、藤井敏
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] インフルエンザウイルスのRNAポリメラーゼサブユニットPANの精製と単結晶化2012
- Author(s)
  石川吉伸、尾崎公英、横山英志、藤井敏
- Organizer
  第 22 回日本病院薬剤師会東海ブロック学術大会・平成24年度日本薬学会東海支部例会
- Place of Presentation
  岐阜市
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] Structure-based Inhibitor Design of Diketo Acid Derivatives Targeting Influenza Virus Metalloenzyme RNA Polymerase2012
- Author(s)
  Yoshinobu Ishikawa, Atsushi Ugai, Seiji Miyazaki, Noriyuki Ishigaki, Kimihide Ozaki, Hideshi Yokoyama, Satoshi Fujii
- Organizer
  40th International Conference on Coordination Chemistry
- Place of Presentation
  Valencia, Spain
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] インフルエンザウイルスの金属酵素RNAポリメラーゼを標的とするin silico創薬2012
- Author(s)
  石川吉伸、鵜飼淳、鈴木孝史、石垣範行、尾崎公英、横山英志、藤井敏
- Organizer
  第 22 回日本病院薬剤師会東海ブロック学術大会・平成24年度日本薬学会東海支部例会
- Place of Presentation
  岐阜市
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] インフルエンザウィルスの金属酵素RNAポリメラーゼを阻害するアリールジケト酸誘導体のSB&CADD2012
- Author(s)
  石川吉伸、鵜飼淳、鈴木孝史、石垣範行、尾崎公英、横山英志、藤井敏
- Organizer
  第30回メディシナルケミストリーシンポジウム
- Place of Presentation
  船堀市
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] Binding mode prediction and design of diketo acid derivatives inhibiting Influenza Viral Metalloenzyme RNA Polymerase2011
- Author(s)
  Yoshinobu Ishikawa and Satoshi Fujii
- Place of Presentation
  Cambridge, UK
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] Binding mode prediction and design of diketo acid derivatives in hibiting Influenza Viral Metalloenzyme RNA Polymerase2011
- Author(s)
  Yoshinobu Ishikawa, Satoshi Fujii
- Organizer
  16th SCI-RSC Cambridge Medicinal Chemistry Symposium
- Place of Presentation
  Cambridge, UK
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] Structure-based Drug Design of Diketo Acid Derivatives inhibiting Influenza Viral Metalloenzyme RNA Polymerase2010
- Author(s)
  Yoshinobu Ishikawa, Satoshi Fujii
- Organizer
  International Symposium of Medicinal Chemistry
- Place of Presentation
  Brussels, Belgium
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] インフルエンザウィルスの金属酵素RNAポリメラーゼに対するジケト酸誘導体の分子ドッキング2010
- Author(s)
  石川吉伸, 藤井敏
- Organizer
  日本薬学会第130年会(岡山)
- Place of Presentation
  岡山大学
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] インフルエンザウィルスの金属酵素RNAポリメラーゼに対するジケト酸誘導体の分子ドッキング2010
- Author(s)
  石川吉伸、藤井敏
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] Binding mode prediction and rational design of diketo acid derivatives targeting metalloenzyme RNA polymerase of influenza virus2010
- Author(s)
  Yoshinobu Ishikawa, Satoshi Fujii
- Organizer
  第38回構造活性相関シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2010-10-31
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] インフルエンザウィルス由来金属酵素RNAポリメラーゼに対するジケト酸誘導体の分子ドッキングによる結合様式予測2009
- Author(s)
  石川吉伸, 藤井敏
- Organizer
  第19回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  大阪大学
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] カチオン性ポルフィリンTMPyP4の二分子グアニン四重鎖DNAへの分子ドッキング2009
- Author(s)
  石川吉伸, 藤井敏
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都国際会館
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] インフルエンザウィルス由来金属酵素RNAポリメラーゼに対するジケト酸誘導体の分子ドッキングによる結合様式予測2009
- Author(s)
  石川吉伸、藤井敏
- Organizer
  第19回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] テロメア四重鎖DNAを標的とするカチオン性ポルフィリンの抗腫瘍細胞増殖能2009
- Author(s)
  石川吉伸
- Organizer
  静岡県立大学 2008USフォーラム
- Place of Presentation
  静岡県立大学
- Year and Date
  2009-08-04
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] テロメア四重鎖DNAを標的とするカチオン性ポルフィリンの抗腫瘍細胞増殖能2009
- Author(s)
  石川吉伸
- Organizer
  静岡県立大学2008 USフォーラム
- Place of Presentation
  静岡
- Year and Date
  2009-08-04
- Data Source
  KAKENHI-PROJECT-21590118
[Presentation] カチオン性ポルフィリンTMPyP4の二分子グアニン四重鎖DNAへの分子ドッキング2009
- Author(s)
  石川吉伸、藤井敏
- Organizer
  第129回日本薬学会年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Amino Acid Residues Responsible for the Stabilization of Hemoglobin Tetramer2008
- Author(s)
  宇野公之、瀧川総太郎、石丸武史、清田浩平、甲斐俊哉、石川吉伸、富杉佳計、青山浩
- Organizer
  第18回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] インドールアミン2,3- ジオキシゲナーゼ(IDO)のヘム周辺環境と触媒機構2008
- Author(s)
  宇野公之、英杏子、牛田真衣、松浦明美、中山智香子、石川吉伸、富杉佳計、青山浩
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヘモグロビン四量体の会合安定化に関わるアミノ酸残基2008
- Author(s)
  宇野公之、瀧川総太郎、石丸武史、清田浩平、甲斐俊哉、石川吉伸、富杉佳計、青山浩
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Molecular docking study of binding of TMPyP4 to a bimolecular human telomeric G-quadruplex2008
- Author(s)
  石川吉伸、藤井敏
- Organizer
  第35回核酸化学シンポジウム
- Place of Presentation
  京都
- Year and Date
  2008-09-08
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] The Heme Environment of Human Indoleamine 2,3-Dioxygenase2008
- Author(s)
  宇野公之、英杏子、牛田真衣、松浦明美、中山智香子、石川吉伸、富杉佳計、青山浩
- Organizer
  第18回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] カチオン性ポルフィリンTMPyP4の二分子グアニン四重鎖DNAへの分子ドッキングシミュレーション2008
- Author(s)
  石川吉伸、藤井敏
- Organizer
  第54回日本薬学会東海支部大会
- Place of Presentation
  名古屋
- Year and Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP2C19における一塩基多型と代謝活性の相関2008
- Author(s)
  佐々木隆一、Sayed M. S. Ali、小山由希子、石川吉伸、富杉佳計、青山浩、宇野公之
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP2C9の薬物結合性及び選択性を決定する残基の評価2008
- Author(s)
  香川雄輔、佐々木隆一、渡辺亮介、石川吉伸、富杉佳計、青山浩、宇野公之
- Organizer
  日本薬学会128年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP2C9の一塩基多型と薬物代謝活性との相関2007
- Author(s)
  宇野公之、香川雄輔、渡辺亮介、繁富輝明、植田哲嗣、富杉佳計、石川吉伸、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Molecular Docking of porphyrins with cationic limbs on Intramolecular G-quadruplex2007
- Author(s)
  Ishikawa Y., Higashi E. and Morioka H.
- Organizer
  第5回国際核酸化学シンポジウム
- Place of Presentation
  東京大学
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Interaction of cationic porphyrin TMPyP4 with quadruplex DNA: a molecular dynamics simulation study2007
- Author(s)
  Yoshinobu ishikawa
- Organizer
  13th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  ウィーン
- Year and Date
  2007-07-16
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP1A2の薬物結合性と代謝活性 ~一塩基多型が及ぼす影響~2007
- Author(s)
  宇野公之、辻本景英、江川真文、村田晋一、永井英次、石川吉伸、富杉佳計、前田初男
- Organizer
  日本薬学会127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] ヒト薬物代謝酵素CYP1A2の薬物結合性と代謝活性に対する一塩基多型の影響2007
- Author(s)
  宇野公之、辻本景英、江川真文、村田晋一、永井英次、石川吉伸、富杉佳計、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] NO運搬タンパク質ニトロフォリン4の配位子結合に対する酸性残基の役割2007
- Author(s)
  宇野公之、大場伸紘、森山友美子、石川吉伸、富杉佳計、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] NO運搬タンパク質ニトロフォリン4(NP4)の外来性配位子結合機構の解明2007
- Author(s)
  宇野公之、大場伸紘、森山友美子、石川吉伸、富杉佳計、前田初男
- Organizer
  日本薬学会127年会
- Place of Presentation
  富山
- Year and Date
  2007-03-29
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] 薬物代謝酵素CYP2C19の基質認識と一塩基多型の影響2007
- Author(s)
  宇野公之、佐々木隆一、Sayed M.S. Ali、小山由希子、石川吉伸、富杉佳計、前田初男
- Organizer
  第17回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  京都
- Year and Date
  2007-06-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Molecular Docking of Porphyrins with Cationic Limbs on Intramolecular G-quadruplex2007
- Author(s)
  石川吉伸、東栄希、森岡弘志
- Organizer
  第34回核酸化学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Molecular Modeling of Anti-parallel G-quadruplex DNA/TMPyP complexes2006
- Author(s)
  石川吉伸、富杉佳計、宇野公之
- Organizer
  第33回核酸化学シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2006-11-21
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Resonance Raman Studies of CYP2C19 and Its Complexes with Substrates2006
- Author(s)
  Sayed M. S. Ali, Yukiko Oyama, Yoshinobu Ishikawa, Yoshikazu Tomisugi, Hatsuo Maeda, and Tadayuki Uno
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Exogenous Ligand Binding Mechanism of Cytoglobin2006
- Author(s)
  Tadayuki Uno, Kaori Kukino, Hatsuo Maeda, Yoshikazu Tomisugi, Yoshinobu Ishikawa, Norifumi Kawada, Katsutoshi Yoshizato, Hitomi Sawai, and Yoshitsugu Shiro
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] サイトグロビン及びニューログロビンの外来性配位子結合機構2006
- Author(s)
  宇野公之、久木野香里、堤紘子、龍大輔、前田初男、富杉佳計、石川吉伸、河田則文、吉里勝利、澤井仁美、城宜嗣
- Organizer
  第16回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  東京
- Year and Date
  2006-06-01
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Over-expression of Recombinant Human Hemoglobin2006
- Author(s)
  Tadayuki Uno, Takefumi Ishimaru, Sohtaro Takigawa, Yohei Hoashi, Toshiya Kai, Yoshikazu Tomisugi, Yoshinobu Ishikawa, and Hatsuo Maeda
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] CYP1A2の一塩基多型による薬物結合性と代謝活性の変化2006
- Author(s)
  宇野公之、江川真文、村田晋一、辻本景英、前田初男、富杉佳計、石川吉伸
- Organizer
  第16回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  東京
- Year and Date
  2006-06-01
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] 組換え型ヒトヘモグロビン大量発現系の構築2006
- Author(s)
  宇野公之、石丸武史、帆足洋平、甲斐俊哉、前田初男、富杉佳計、石川吉伸
- Organizer
  第16回金属の関与する生体関連反応シンポジウム
- Place of Presentation
  東京
- Year and Date
  2006-06-01
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Substrate Binding and Metabolizing Properties of Indoleamine 2,3-Dioxygenase2006
- Author(s)
  Tadayuki Uno, Mai Ushida, Akemi Matsuura, Chikako Nakayama, Tomoko Hosokawa, Yoshikazu Tomisugi, Yoshinobu Ishikawa, and Hatsuo Maeda
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] Roles of Cysteine Residues in the Gas Binding to Human Neuroglobin2006
- Author(s)
  Tadayuki Uno, Leila Hafsi, Hiroko Tsutsumi, Daisuke Ryu, Yoshikazu Tomisugi, Yoshinobu Ishikawa, and Hatsuo Maeda
- Organizer
  5th East Asian Biophysics Symposium & 44th Annual Meeting of the Biophysical Society of Japan
- Place of Presentation
  宜野湾
- Year and Date
  2006-11-13
- Data Source
  KAKENHI-PROJECT-18590098
[Presentation] キネシンEg5とATP競合阻害剤との複合体の結晶構造
- Author(s)
  横山英志、澤田潤一、加藤詩織、松野研司、小郷尚久、石川吉伸、藤井敏、浅井章良、橋本博
- Organizer
  平成26年度日本結晶学会年会
- Place of Presentation
  東京
- Year and Date
  2014-11-01 – 2014-11-03
- Data Source
  KAKENHI-PROJECT-24590141
[Presentation] ギ酸誘導体の一酸化炭素生成機構およびこれを用いる実用的有機合成反応
- Author(s)
  小西英之、上田剛、松原美香、森敬介、石川吉伸、橋本博、常盤広明、眞鍋敬
- Organizer
  第40回反応と合成の進歩シンポジウム
- Place of Presentation
  仙台
- Year and Date
  2014-11-10 – 2014-11-11
- Data Source
  KAKENHI-PROJECT-24590141

1. 安藤隆幸 (40402226)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. UNO Tadayuki (00183020)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
3. TOMISUGI Yoshikazu (80322311)

# of Collaborated Projects: 3 results

# of Collaborated Products: 27 results
4. YOKOYAMA Hideshi (70433208)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. Fujimura Atsushi (10771082)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. Kohzaki Masaoki (90717977)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. MURATA Toshihiro (70458214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. UMEHARA Kaoru (40185070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. SUGANUMA Keisuke (60772184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SASAKI Kenroh (90244970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. Ashizawa Tadashi (10443441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Serizawa Masakuni (00569915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 大島啓一 (10399587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 釼持広知 (50602637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 盛啓太 (50727534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 黒住和彦 (20509608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 富澤一仁 (40274287)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 増本年男 (40715083)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 中村仁 (50828407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 魏范研 (90555773)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 工藤晃大 (40911433)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 加藤紘一 (80814821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 香川亘 (70415123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SASAMOTO Kazumi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. BATKHUU Javzan

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. DAVAAPUREV Bekh-Ochir

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. ODONTUYA Gendaram

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. SELENGE Erdenechimeg

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
29. ISHIKAWA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 五十里彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 滝川修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 菅敏幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 稲井誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 橋本博

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
35. 原幸大

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
36. 常盤広明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 北泰行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ishikawa Yoshinobu 石川 吉伸

ISHIKAWA Yoshinobu 石川 吉伸

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AS-MSによるPD-1ーPD-L1低分子阻害剤の探索Principal Investigator

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Development of urease inhibitors considering halogen bondingPrincipal Investigator

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SBDD targeting metalloenzyme RNA polymeraze of influenza virusPrincipal Investigator

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Synthesis and analysis of telomere quadruplex DNA-binding porphyrins based on an electrostatic interaction modelPrincipal Investigator

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Predicition and verification for the structures and thermodynamic properties of telomeric DNA quadruplex/porphyrin complexesPrincipal Investigator

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テロメアDNA四重鎖構造を安定化させテロメラーゼを阻害するポルフィリンの開発Principal Investigator

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Ishikawa Yoshinobu 石川吉伸

ISHIKAWA Yoshinobu 石川吉伸